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Aliases for SV2B Gene

Aliases for SV2B Gene

  • Synaptic Vesicle Glycoprotein 2B 2 3
  • KIAA0735 4 6
  • Synaptic Vesicle Protein 2B Homolog 3
  • HsT19680 3

External Ids for SV2B Gene

Summaries for SV2B Gene

GeneCards Summary for SV2B Gene

SV2B (Synaptic Vesicle Glycoprotein 2B) is a Protein Coding gene. Diseases associated with SV2B include prostate small cell carcinoma. Among its related pathways are Focal adhesion. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SV2C.

UniProtKB/Swiss-Prot for SV2B Gene

  • Probably plays a role in the control of regulated secretion in neural and endocrine cells.

Gene Wiki entry for SV2B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SV2B Gene

Genomics for SV2B Gene

Genomic Location for SV2B Gene

Start:
91,099,773 bp from pter
End:
91,301,309 bp from pter
Size:
201,537 bases
Orientation:
Plus strand

Genomic View for SV2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SV2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SV2B Gene

Regulatory Elements for SV2B Gene

Proteins for SV2B Gene

  • Protein details for SV2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L1I2-SV2B_HUMAN
    Recommended name:
    Synaptic vesicle glycoprotein 2B
    Protein Accession:
    Q7L1I2
    Secondary Accessions:
    • B4DH30
    • C6G489
    • O94840
    • Q6IAR8

    Protein attributes for SV2B Gene

    Size:
    683 amino acids
    Molecular mass:
    77444 Da
    Quaternary structure:
    • Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 (By similarity).
    SequenceCaution:
    • Sequence=BAA34455.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SV2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SV2B Gene

Proteomics data for SV2B Gene at MOPED

Post-translational modifications for SV2B Gene

Other Protein References for SV2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SV2B Gene

Domains for SV2B Gene

Protein Domains for SV2B Gene

UniProtKB/Swiss-Prot:

SV2B_HUMAN
Family:
  • Belongs to the major facilitator superfamily.:
    • Q7L1I2
genes like me logo Genes that share domains with SV2B: view

No data available for Gene Families for SV2B Gene

Function for SV2B Gene

Molecular function for SV2B Gene

UniProtKB/Swiss-Prot Function: Probably plays a role in the control of regulated secretion in neural and endocrine cells.

Gene Ontology (GO) - Molecular Function for SV2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005515 protein binding IPI 25416956
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SV2B: view
genes like me logo Genes that share phenotypes with SV2B: view

Animal Models for SV2B Gene

MGI Knock Outs for SV2B:

miRNA for SV2B Gene

miRTarBase miRNAs that target SV2B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SV2B Gene

Localization for SV2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SV2B Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas. Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SV2B Gene COMPARTMENTS Subcellular localization image for SV2B gene
Compartment Confidence
peroxisome 2

Gene Ontology (GO) - Cellular Components for SV2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005886 plasma membrane TAS --
GO:0008021 synaptic vesicle TAS 15217342
GO:0016020 membrane ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SV2B: view

Pathways for SV2B Gene

SuperPathways for SV2B Gene

Superpath Contained pathways
1 Focal adhesion
genes like me logo Genes that share pathways with SV2B: view

Pathways by source for SV2B Gene

1 KEGG pathway for SV2B Gene

Gene Ontology (GO) - Biological Process for SV2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006836 neurotransmitter transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SV2B: view

Compounds for SV2B Gene

(1) HMDB Compounds for SV2B Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with SV2B: view

Transcripts for SV2B Gene

Unigene Clusters for SV2B Gene

Synaptic vesicle glycoprotein 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SV2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: -
SP3:

Relevant External Links for SV2B Gene

GeneLoc Exon Structure for
SV2B
ECgene alternative splicing isoforms for
SV2B

Expression for SV2B Gene

mRNA expression in normal human tissues for SV2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SV2B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.9), Brain - Cortex (8.2), Brain - Cerebellar Hemisphere (7.2), Brain - Anterior cingulate cortex (BA24) (7.1), and Brain - Cerebellum (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SV2B Gene

SOURCE GeneReport for Unigene cluster for SV2B Gene Hs.21754

genes like me logo Genes that share expressions with SV2B: view

Orthologs for SV2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SV2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SV2B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SV2B 36
  • 90.78 (n)
  • 95.02 (a)
SV2B 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SV2B 36
  • 91.9 (n)
  • 95.61 (a)
SV2B 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sv2b 36
  • 89.6 (n)
  • 94.88 (a)
Sv2b 16
Sv2b 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SV2B 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SV2B 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sv2b 36
  • 89.85 (n)
  • 94.88 (a)
chicken
(Gallus gallus)
Aves SV2B 36
  • 78.25 (n)
  • 81.96 (a)
SV2B 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SV2B 37
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sv2b 36
  • 71.96 (n)
  • 76.32 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101883740 36
  • 66.27 (n)
  • 66.27 (a)
SV2B (2 of 3) 37
  • 63 (a)
OneToMany
sv2ba 37
  • 59 (a)
OneToMany
sv2bb 37
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12783 37
  • 19 (a)
ManyToMany
CG14691 37
  • 20 (a)
ManyToMany
CG15221 37
  • 20 (a)
ManyToMany
CG31103 37
  • 20 (a)
ManyToMany
CG31106 37
  • 23 (a)
ManyToMany
CG31272 37
  • 22 (a)
ManyToMany
CG3168 37
  • 27 (a)
ManyToMany
CG33233 37
  • 20 (a)
ManyToMany
CG33234 37
  • 18 (a)
ManyToMany
CG3690 37
  • 22 (a)
ManyToMany
CG3168 38
  • 33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAPB1E7.08c 36
  • 41.05 (n)
  • 28.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToMany
Species with no ortholog for SV2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SV2B Gene

ENSEMBL:
Gene Tree for SV2B (if available)
TreeFam:
Gene Tree for SV2B (if available)

Paralogs for SV2B Gene

Paralogs for SV2B Gene

Selected SIMAP similar genes for SV2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SV2B: view

Variants for SV2B Gene

Sequence variations from dbSNP and Humsavar for SV2B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs719176 -- 91,242,063(-) gagag(C/T)tgact intron-variant
rs719985 -- 91,161,421(-) TATTT(C/T)TCTTA intron-variant
rs719986 -- 91,161,367(-) GCCAC(C/T)CTAAT intron-variant
rs719987 -- 91,161,262(-) tggtt(C/T)gatac intron-variant
rs730616 -- 91,174,766(-) GAACC(A/G)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SV2B Gene

Variant ID Type Subtype PubMed ID
esv26699 CNV Loss 19812545
esv8530 CNV Gain 19470904
nsv904496 CNV Loss 21882294
esv2750021 CNV Deletion 23290073
nsv904497 CNV Gain 21882294
nsv1663 CNV Loss 18451855
esv2011261 CNV Deletion 18987734
esv2750022 CNV Deletion 23290073
esv2750023 CNV Deletion 23290073
dgv778e1 CNV Complex 17122850
nsv833094 CNV Gain 17160897
esv26104 CNV Loss 19812545
esv2750024 CNV Deletion 23290073

Relevant External Links for SV2B Gene

HapMap Linkage Disequilibrium report
SV2B
Human Gene Mutation Database (HGMD)
SV2B

Disorders for SV2B Gene

(1) University of Copenhagen DISEASES for SV2B Gene

Relevant External Links for SV2B

Genetic Association Database (GAD)
SV2B
Human Genome Epidemiology (HuGE) Navigator
SV2B
genes like me logo Genes that share disorders with SV2B: view

No data available for UniProtKB/Swiss-Prot for SV2B Gene

Publications for SV2B Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Brain contains two forms of synaptic vesicle protein 2. (PMID: 7681585) Bajjalieh S.M. … Scheller R.H. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PMID: 18367154) Verma R. … Levinson D.F. (Biol. Psychiatry 2008) 3 49

Products for SV2B Gene

Sources for SV2B Gene

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