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SV2B Gene

protein-coding   GIFtS: 63
GCID: GC15P091643

Synaptic Vesicle Glycoprotein 2B

  See SV2B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptic Vesicle Glycoprotein 2B1 2
KIAA07353 5
HsT196802
Synaptic Vesicle Protein 2B Homolog2

External Ids:    HGNC: 168741   Entrez Gene: 98992   Ensembl: ENSG000001855187   OMIM: 1858615   UniProtKB: Q7L1I23   

Export aliases for SV2B gene to outside databases

Previous GC identifers: GC15P088231 GC15P085534 GC15P089356 GC15P089498 GC15P089373 GC15P089444 GC15P089570 GC15P067755


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SV2B Gene:
SV2B (synaptic vesicle glycoprotein 2B) is a protein-coding gene. Diseases associated with SV2B include prostate small cell carcinoma. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SV2C.

UniProtKB/Swiss-Prot: SV2B_HUMAN, Q7L1I2
Function: Probably plays a role in the control of regulated secretion in neural and endocrine cells (By
similarity)

Gene Wiki entry for SV2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SV2B gene promoter:
         HFH-3   AML1a   POU6F1 (c2)   CUTL1   LCR-F1   FOXI1   PPAR-alpha   STAT3   Cart-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSV2B promoter sequence
   Search Chromatin IP Primers for SV2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SV2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

SV2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SV2B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P091643:  view genomic region     (about GC identifiers)

Start:
91,643,180 bp from pter      End:
91,844,539 bp from pter
Size:
201,360 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SV2B_HUMAN, Q7L1I2 (See protein sequence)
Recommended Name: Synaptic vesicle glycoprotein 2B  
Size: 683 amino acids; 77444 Da
Subunit: Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 (By
similarity)
Sequence caution: Sequence=BAA34455.2; Type=Erroneous initiation;
Secondary accessions: B4DH30 C6G489 O94840 Q6IAR8
Alternative splicing: 2 isoforms:  Q7L1I2-1   Q7L1I2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SV2B: NX_Q7L1I2

Explore proteomics data for SV2B at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • The N-terminal cytoplasmic domain is phosphorylated by CK1 (By similarity)1
  • Glycosylation2 at Asn441, Asn491, Asn516
  • Modification sites at PhosphoSitePlus

  • See SV2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161052.1  NP_055663.1  

    ENSEMBL proteins: 
     ENSP00000443243   ENSP00000377779   ENSP00000450992   ENSP00000332818  
    Reactome Protein details: Q7L1I2

    SV2B Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SV2B
    OriGene Custom MassSpec
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    Novus Biologicals SV2B Proteins
    Novus Biologicals SV2B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SV2B

     
    Search eBioscience for Proteins for SV2B 

     
    antibodies-online proteins for SV2B (4 products) 

     
    Search antibodies-online for peptides for SV2B

    SV2B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SV2B
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    antibodies-online antibodies for SV2B (25 products) 

    SV2B Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SV2B
    Cloud-Clone Corp. CLIAs for SV2B
    Search eBioscience for ELISAs for SV2B 
    antibodies-online kits for SV2B (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR005829 Sugar_transporter_CS
     IPR022308 SV2
     IPR001646 5peptide_repeat
     IPR005828 Sub_transporter
     IPR020846 MFS_dom

    Graphical View of Domain Structure for InterPro Entry Q7L1I2

    ProtoNet protein and cluster: Q7L1I2

    UniProtKB/Swiss-Prot: SV2B_HUMAN, Q7L1I2
    Similarity: Belongs to the major facilitator superfamily


    Find genes that share domains with SV2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SV2B_HUMAN, Q7L1I2
    Function: Probably plays a role in the control of regulated secretion in neural and endocrine cells (By
    similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0022857transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SV2B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SV2B:
     Synthetic lethal with imatinib 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sv2b):
     behavior/neurological  cellular  growth/size/body  mortality/aging  nervous system 
     normal  vision/eye 

    Find genes that share phenotypes with SV2B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SV2B: Sv2btm1Baj Sv2btm1Sud

       genOway: Develop your customized and physiologically relevant rodent model for SV2B

    miRNA
    Products:
        
    miRTarBase miRNAs that target SV2B:
    hsa-mir-26b-5p (MIRT030144)

    Block miRNA regulation of human, mouse, rat SV2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SV2B (see all 72):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-631 hsa-miR-106a hsa-miR-938 hsa-miR-3653 hsa-miR-759 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidSV2B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SV2B
    Search Predesigned siRNA for gene silencing in human, mouse, rat SV2B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SV2B

    Clone
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    OriGene clones in human, mouse for SV2B (see all 11)
    OriGene ORF clones in mouse, rat for SV2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SV2B (NM_014848)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SV2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SV2B

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SV2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SV2B_HUMAN, Q7L1I2: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane
    protein (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Note=Associated with
    synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas.
    Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0008021synaptic vesicle ----
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0030054cell junction IEA--

    Find genes that share ontologies with SV2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SV2B About    
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    ECM-receptor interaction0.31


    Find genes that share SuperPaths with SV2B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Reactome Pathways for SV2B
        Toxicity of botulinum toxin type D (BoNT/D)
    Toxicity of botulinum toxin type E (BoNT/E)
    Toxicity of botulinum toxin type F (BoNT/F)
    Toxicity of botulinum toxin type A (BoNT/A)


    1 Kegg Pathway  (Kegg details for SV2B):
        ECM-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including SV2B: 
              Parkinson's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SV2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for SV2B (Q7L1I23 ENSP000003328184) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000229432Q6UXA73, ENSP000003994364I2D: score=1 STRING: ENSP00000399436
    C6orf15Q6UXA73I2D: score=1 
    ENSG00000206461Q6UXA73I2D: score=1 
    ENSG00000224105Q6UXA73I2D: score=1 
    ENSG00000225543Q6UXA73I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006836neurotransmitter transport IEA--
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with SV2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SV2B

    1 HMDB Compound for SV2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SV2B gene (2 alternative transcripts): 
    NM_001167580.1  NM_014848.4  

    Unigene Cluster for SV2B:

    Synaptic vesicle glycoprotein 2B
    Hs.21754  [show with all ESTs]
    Unigene Representative Sequence: NM_014848
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000545111 ENST00000394232(uc002bqt.3 uc002bqv.3 uc010uqv.2)
    ENST00000557410(uc002bqu.4) ENST00000557291 ENST00000553727 ENST00000330276

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SV2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SV2B (see all 72):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-631 hsa-miR-106a hsa-miR-938 hsa-miR-3653 hsa-miR-759 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidSV2B 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for SV2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SV2B (NM_014848)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SV2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SV2B
    Primer
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    OriGene qPCR primer pairs and template standards for SV2B
    OriGene qSTAR qPCR primer pairs in human, mouse for SV2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SV2B
      QuantiTect SYBR Green Assays in human, mouse, rat SV2B
      QuantiFast Probe-based Assays in human, mouse, rat SV2B

    Additional mRNA sequence: 

    AB018278.1 AF052188.1 AK124722.1 AK294902.1 AL109781.1 AL110287.1 CR457086.1 

    7 DOTS entries:

    DT.65286722  DT.85105504  DT.65287524  DT.91672216  DT.99962838  DT.121050843  DT.121050833 

    Selected AceView cDNA sequences (see all 129):

    Z38825 Z45862 BC030011 BQ188998 Z41392 BU728741 BQ022110 R85412 
    AB018278 Z42664 NM_014848 BM712472 BI820258 AI168172 AA256847 BQ184405 
    Z41494 AF052188 AA903532 BE503998 BU729732 AA013453 AI669959 T30897 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SV2B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                  -                                             
    SP2:                                                  -                                             
    SP3:                                                                                                


    ECgene alternative splicing isoforms for SV2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SV2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTACCCCA
    SV2B Expression
    About this image


    SV2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Midbrain tegmentum
     
     Thymus (Hematopoietic System)
             Thymus
     
     NULL (Uncategorized)
             Endoderm progenitor-like cells
     
     Kidney (Urinary System)
             Metanephros
    SV2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SV2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.21754
        Pathway & Disease-focused RT2 Profiler PCR Array including SV2B: 
              Parkinson's Disease in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SV2B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SV2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SV2B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sv2b1 , 5 synaptic vesicle glycoprotein 2 b1, 5 89.6(n)1
    94.88(a)1
      7 (43.62 cM)5
    641761  NM_153579.41  NP_705807.21 
     751148975 
    chicken
    (Gallus gallus)
    Aves SV2B1 synaptic vesicle glycoprotein 2B 78.25(n)
    81.96(a)
      427508  XM_004943861.1  XP_004943918.1 
    lizard
    (Anolis carolinensis)
    Reptilia SV2B6
    synaptic vesicle glycoprotein 2B
    77(a)
    1 ↔ 1
    GL343392.1(395467-481574)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sv2b1 synaptic vesicle glycoprotein 2B 71.96(n)
    76.32(a)
      100497731  XM_004912656.1  XP_004912713.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018837401 synaptic vesicle glycoprotein 2B-like 66.27(n)
    66.27(a)
      101883740  XM_005161518.1  XP_005161575.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG31683   -- 33(a)   6C9   --


    ENSEMBL Gene Tree for SV2B (if available)
    TreeFam Gene Tree for SV2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SV2B gene
    SV2C2  SV2A2  SVOPL2  SVOP2  
    2 SIMAP similar genes for SV2B using alignment to 1 protein entry:     SV2B_HUMAN:
    SV2A    SV2C

    Find genes that share paralogs with SV2B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SV2B (see all 4695)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30820991,2
    C--71428820(+) aaaca-/TAcgcta 2 -- int11Minor allele frequency- TA:0.00NA 2
    rs1156922511,2
    F--91641409(+) AGAGTA/TCATAC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1488708781,2
    C--91641461(+) GCAGGC/TGATAC 1 -- us2k10--------
    rs727631481,2
    C,F--91641492(+) CAGAGT/CGGTGG 1 -- us2k13Minor allele frequency- C:0.38NA CSA 124
    rs1435159681,2
    --91641533(+) CCTGGC/GAAAGA 1 -- us2k10--------
    rs1836092241,2
    --91641554(+) ACCCCA/TTGATG 2 -- us2k10--------
    rs13140511,2
    C,F,O,A,H--91641596(-) TGCtaT/Cagcca 2 -- us2k118Minor allele frequency- C:0.33MN NS EA NA WA CSA 978
    rs1452443651,2
    C--91641625(+) CGATA-/TTCTGG 2 -- us2k10--------
    rs347972861,2
    C,F--91641666(+) GCGTGC/TGTTCC 2 -- us2k12Minor allele frequency- T:0.03WA 120
    rs1379188541,2
    --91641816(+) GAGGAA/GGAGAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SV2B (91643180 - 91844539 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SV2B (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2011261CNV Deletion18987734
    esv2750024CNV Deletion23290073
    esv2750021CNV Deletion23290073
    esv2750022CNV Deletion23290073
    esv2750023CNV Deletion23290073
    nsv904496CNV Loss21882294
    esv26699CNV Loss19812545
    esv26104CNV Loss19812545
    nsv1663CNV Loss18451855
    nsv904497CNV Gain21882294

    Human Gene Mutation Database (HGMD): SV2B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SV2B
    DNA2.0 Custom Variant and Variant Library Synthesis for SV2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 185861    OMIM disorders: --

    1 disease for SV2B:    
    About MalaCards
    prostate small cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for SV2B:
    Prostate small cell carcinoma

    Find genes that share disorders with SV2B           About GenesLikeMe

    Genetic Association Database (GAD): SV2B
    Human Genome Epidemiology (HuGE) Navigator: SV2B (6 documents)

    Export disorders for SV2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SV2B gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with SV2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy. (PubMed id 18977120)1, 4 Lynch J.M....Sisodiya S.M. (Epilepsy Res. 2009)
    5. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. (PubMed id 19043545)1, 4 Gieger C....Suhre K. (PLoS Genet. 2008)
    6. Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PubMed id 18367154)1, 4 Verma R....Levinson D.F. (Biol. Psychiatry 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Brain contains two forms of synaptic vesicle protein 2. (PubMed id 7681585)1, 3 Bajjalieh S.M....Scheller R.H. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    10. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)4 Wang J....Platt A. (Pharmacogenomics J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9899 HGNC: 16874 AceView: SV2B Ensembl:ENSG00000185518 euGenes: HUgn9899
    ECgene: SV2B Kegg: 9899 H-InvDB: SV2B

    (According to HUGE)
    About This Section

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    HUGE: KIAA0735

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SV2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SV2B gene:
    Search GeneIP for patents involving SV2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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