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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SV2B Gene

protein-coding   GIFtS: 61
GCID: GC15P091643

synaptic vesicle glycoprotein 2B
 Explore 6 diseases affiliated with
SV2B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SV2B    

Aliases
for SV2B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Synaptic Vesicle Glycoprotein 2B1 2
HsT196801 2
KIAA07351 3
Synaptic Vesicle Protein 2B Homolog2

External Ids:    HGNC: 168741   Entrez Gene: 98992   Ensembl: ENSG000001855187   OMIM: 1858615   UniProtKB: Q7L1I23   

Export aliases for SV2B gene to outside databases

Previous GC identifers: GC15P088231 GC15P085534 GC15P089356 GC15P089498 GC15P089373 GC15P089444 GC15P089570 GC15P067755


Summaries
for SV2B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SV2B_HUMAN, Q7L1I2
Function: Probably plays a role in the control of regulated secretion in neural and endocrine cells (By similarity)

Gene Wiki entry for SV2B


Genomic Views
for SV2B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010274.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SV2B gene promoter:
         HFH-3   AML1a   POU6F1 (c2)   CUTL1   LCR-F1   FOXI1   PPAR-alpha   STAT3   Cart-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SV2B promoter sequence
   Search SABiosciences Chromatin IP Primers for SV2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SV2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

SV2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SV2B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P091643:  view genomic region     (about GC identifiers)

Start:
 91,643,180 bp from pter      End:
 91,844,539 bp from pter
Size:
 201,360 bases      Orientation:
 plus strand

Proteins
for SV2B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SV2B_HUMAN, Q7L1I2 (See protein sequence)
Recommended Name: Synaptic vesicle glycoprotein 2B  
Size: 683 amino acids; 77444 Da
Subunit: Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 (By
similarity)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein
(By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Note=Associated with synaptic-like
microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas. Localizes to
microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity)
Sequence caution: Sequence=BAA34455.2; Type=Erroneous initiation;
Secondary accessions: B4DH30 C6G489 O94840 Q6IAR8
Alternative splicing: 2 isoforms:  Q7L1I2-1   Q7L1I2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SV2B: NX_Q7L1I2

Post-translational modifications:

  • N-glycosylated (By similarity)1
  • The N-terminal cytoplasmic domain is phosphorylated by CK1 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7L1I2

    • SV2B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161052.1  NP_055663.1  

    ENSEMBL proteins: 
     ENSP00000443243   ENSP00000377779   ENSP00000450992   ENSP00000332818  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: SV2B
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    Novus Biologicals SV2B Proteins
    Novus Biologicals SV2B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SV2B

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0008021synaptic vesicle ----
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--


    SV2B for ontologies           About GeneDecksing



    SV2B Antibody Products: 
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    Uscn Antibodies for SV2B
    Search ThermoFisher Antibodies for SV2B

    Assay Products for SV2B: 
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    Uscn ELISAs and CLIAs for SV2B

    Protein Domains /
    Families
    for SV2B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SV2B for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR005829 Sugar_transporter_CS
     IPR022308 SV2
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR011701 MFS

    Graphical View of Domain Structure for InterPro Entry Q7L1I2

    ProtoNet protein and cluster: Q7L1I2

    UniProtKB/Swiss-Prot: SV2B_HUMAN, Q7L1I2
    Similarity: Belongs to the major facilitator superfamily


    Function
    for SV2B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SV2B_HUMAN, Q7L1I2
    Function: Probably plays a role in the control of regulated secretion in neural and endocrine cells (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SV2B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SV2B
    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate SV2B (see all 72):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-631 hsa-miR-106a hsa-miR-938 hsa-miR-3653 hsa-miR-759 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: SV2B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SV2B (see all 7)
    OriGene shRNA RFP: SV2B
    OriGene siRNA: SV2B
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SV2B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SV2B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SV2B (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SV2B (NM_014848)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SV2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SV2B 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SV2B
    Search LifeMap BioReagents cell lines for SV2B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SV2B

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022857transmembrane transporter activity IEA--


    SV2B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SV2B:
     Synthetic lethal with imatinib 

    Animal Models:
         Mouse knock-outs for SV2B: Sv2btm1Baj Sv2btm1Sud
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sv2b):
     behavior/neurological  cellular  growth/size  mortality/aging  nervous system 
     normal  vision/eye 

    SV2B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SV2B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1ECM-receptor interaction
    		ECM-receptor interaction1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for SV2B):
        ECM-receptor interaction


    SV2B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SV2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/15 Interacting proteins for SV2B (Q7L1I23 ENSP000003328184) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYT1P215793, ENSP000002612054I2D: score=2 STRING: ENSP00000261205
    C6orf15Q6UXA73I2D: score=1 
    LAMA1ENSP000003743094STRING: ENSP00000374309
    LAMA2ENSP000004003654STRING: ENSP00000400365
    LAMA3ENSP000003245324STRING: ENSP00000324532
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport IEA--


    SV2B for ontologies           About GeneDecksing



    Drugs & Compounds
    for SV2B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SV2B

    1 HMDB Compound for SV2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about SV2B 

    Transcripts
    for SV2B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SV2B gene (2 alternative transcripts): 
    NM_001167580.1  NM_014848.4  

    Unigene Cluster for SV2B:

    Synaptic vesicle glycoprotein 2B
    Hs.21754  [show with all ESTs]
    Unigene Representative Sequence: NM_014848
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000545111 ENST00000394232(uc002bqt.3 uc002bqv.3 uc010uqv.2)
    ENST00000557410(uc002bqu.4) ENST00000557291 ENST00000553727 ENST00000330276


    miRNA
    Products:             		 OriGene 3'-UTR Clone: SV2B
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SV2B
    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate SV2B (see all 72):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-631 hsa-miR-106a hsa-miR-938 hsa-miR-3653 hsa-miR-759 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: SV2B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SV2B (see all 7)
    OriGene shRNA RFP: SV2B
    OriGene siRNA: SV2B
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SV2B
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SV2B (NM_014848)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SV2B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SV2B
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SV2B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SV2B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SV2B

    Additional cDNA sequence: 

    AB018278.1 AF052188.1 AK124722.1 AK294902.1 AL109781.1 AL110287.1 CR457086.1 

    7 DOTS entries:

    DT.65286722  DT.85105504  DT.65287524  DT.91672216  DT.99962838  DT.121050843  DT.121050833 

    24/129 AceView cDNA sequences (see all 129):

    Z41392 BU728741 BQ022110 R85412 Z42664 NM_014848 BM712472 BI820258 
    AA256847 BQ184405 AI168172 AF052188 BC030011 AB018278 Z41494 BQ188998 
    Z38825 Z45862 AA975276 BU173438 BM704048 AI701597 BU729934 AI278113 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SV2B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                  -                                             
    SP2:                                                  -                                             
    SP3:                                                                                                


    ECgene alternative splicing isoforms for SV2B

    Expression
    for SV2B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SV2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCTACCCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SV2B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainCerebral CortexBrain
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm progenitor-like cells (Generation and expan...)

    See SV2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SV2B

    SOURCE GeneReport for Unigene cluster: Hs.21754
        SABiosciences Expression via Pathway-Focused PCR Array including SV2B: 
              Parkinson's Disease in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SV2B
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SV2B

    Orthologs
    for SV2B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SV2B gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SV2B1 synaptic vesicle glycoprotein 2B 78.25(n)
    81.96(a)    		   427508  XM_425081.3  XP_425081.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SV2B6
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343392.1(446934-477584)
    zebrafish
    (Danio rerio)    		 Actinopterygii sv2bb1 synaptic vesicle glycoprotein 2 bb 66.32(n)
    66.27(a)    		   100006427  XM_002666792.1  XP_002666838.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG31683   -- 33(a)   6C9   --
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria ygcS6
    yaaU6
    (see all 7)    		 predicted transporter
    (see all 7)    		 20(a)
    19(a)
    (see all 7)    		 possible ortholog
    possible ortholog
    (see all 7)    		 Chromosome(2894555-2895892)
    Chromosome(45807-47138)


    ENSEMBL Gene Tree for SV2B (if available)
    TreeFam Gene Tree for SV2B (if available) 

    Paralogs
    for SV2B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SV2B gene
    SV2C2  SVOPL2  SV2A2  SVOP2  
    2 SIMAP similar genes for SV2B using alignment to 1 protein entry:     SV2B_HUMAN:
    SV2A    SV2C

    SV2B for paralogs           About GeneDecksing



    Genomic Variants
    for SV2B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4031 NCBI SNPs in SV2B are shown (see all 4031)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1156922511,2
    		F,--91641409(+) AGAGTA/TCATAC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1488708781,2
    		--91641461(+) GCAGGC/TGATAC 1 -- us2k10--------
    rs727631481,2
    		C,F,--91641492(+) CAGAGT/CGNNNN 1 -- us2k13Minor allele frequency- C:0.38NA CSA 124
    rs1435159681,2
    		--91641533(+) CCTGGC/GAAAGA 1 -- us2k10--------
    rs1836092241,2
    		--91641554(+) ACCCCA/TTGATG 2 -- us2k10--------
    rs13140511,2
    		C,F,O,A,H,--91641596(-) TGCTAT/CAGCCA 2 -- us2k118Minor allele frequency- C:0.33MN NS EA NA WA CSA 978
    rs1452443651,2
    		--91641625(+) CGATA-/TTCTGG 2 -- us2k10--------
    rs347972861,2
    		C,--91641666(+) GCGTGC/TGTTCC 2 -- us2k12Minor allele frequency- T:0.03WA 120
    rs1379188541,2
    		--91641816(+) GAGGAA/GGAGAT 2 -- us2k10--------
    rs1423762561,2
    		--91641917(+) TAGAGA/GTGAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SV2B (91643180 - 91844539 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for SV2B
         2 CNVs: 66871 3977
         2 Indels: 66872 60190
    Human Gene Mutation Database (HGMD): SV2B

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    Disorders / Diseases
    for SV2B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SV2B for disorders           About GeneDecksing

    OMIM gene information: 185861    OMIM disorders: --

    6 diseases for SV2B:    About MalaCards
    prostate small cell carcinoma    small cell carcinoma    parkinson's disease    prostatitis
    neuronitis    carcinoma

    1 disease from the University of Copenhagen DISEASES database for SV2B:
    Prostate small cell carcinoma
    Human Genome Epidemiology (HuGE) Navigator: SV2B (6 documents)

    Export disorders for SV2B gene to outside databases

    Publications
    for SV2B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SV2B gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with SV2B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Brain contains two forms of synaptic vesicle protein 2. (PubMed id 7681585)1, 3 Bajjalieh S.M....Scheller R.H. (1993)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    7. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    8. No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy. (PubMed id 18977120)1 Lynch J.M....Sisodiya S.M. (2009)
    9. Synaptic vesicle protein 2 binds adenine nucleotides. (PubMed id 18524768)1 Yao J. and Bajjalieh S.M. (2008)
    10. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. (PubMed id 19043545)1 Gieger C....Suhre K. (2008)

    External Searches for SV2B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
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    Genome Databases showing SV2B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9899 HGNC: 16874 AceView: SV2B Ensembl:ENSG00000185518 euGenes: HUgn9899
    ECgene: SV2B Kegg: 9899 H-InvDB: SV2B

    Other Databases showing SV2B gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0735

    Specialized Databases showing SV2B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SV2B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SV2B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SV2B gene:
    Search GeneIP for patents involving SV2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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