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Aliases for SV2A Gene

Aliases for SV2A Gene

  • Synaptic Vesicle Glycoprotein 2A 2 3
  • SV2 3 6
  • KIAA0736 4

External Ids for SV2A Gene

Previous GeneCards Identifiers for SV2A Gene

  • GC01M145617
  • GC01M146649
  • GC01M147091
  • GC01M146688
  • GC01M148141
  • GC01M149874
  • GC01M121255

Summaries for SV2A Gene

GeneCards Summary for SV2A Gene

SV2A (Synaptic Vesicle Glycoprotein 2A) is a Protein Coding gene. Diseases associated with SV2A include gastrointestinal stromal tumor. Among its related pathways are Focal adhesion. GO annotations related to this gene include receptor activity and transmembrane transporter activity. An important paralog of this gene is SV2C.

UniProtKB/Swiss-Prot for SV2A Gene

  • Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).

Tocris Summary for SV2A Gene

Gene Wiki entry for SV2A Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SV2A Gene

Genomics for SV2A Gene

Regulatory Elements for SV2A Gene

Genomic Location for SV2A Gene

Start:
149,903,318 bp from pter
End:
149,917,882 bp from pter
Size:
14,565 bases
Orientation:
Minus strand

Genomic View for SV2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SV2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SV2A Gene

Proteins for SV2A Gene

  • Protein details for SV2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L0J3-SV2A_HUMAN
    Recommended name:
    Synaptic vesicle glycoprotein 2A
    Protein Accession:
    Q7L0J3
    Secondary Accessions:
    • D3DUZ7
    • O94841
    • Q5QNX8
    • Q7Z3L6
    • Q8NBJ6
    • Q9BVZ9

    Protein attributes for SV2A Gene

    Size:
    742 amino acids
    Molecular mass:
    82695 Da
    Quaternary structure:
    • Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2 (By similarity).
    Miscellaneous:
    • Identified as the brain binding-site for the antiepileptic drug levetiracetam/lev
    SequenceCaution:
    • Sequence=BAA34456.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12573.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SV2A Gene

    Alternative splice isoforms for SV2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SV2A Gene

Proteomics data for SV2A Gene at MOPED

Post-translational modifications for SV2A Gene

  • N-glycosylated.
  • Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.
  • Ubiquitination at Lys366, Lys375, and Lys515
  • Glycosylation at Asn498, Asn548, and Asn573
  • Modification sites at PhosphoSitePlus

Other Protein References for SV2A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SV2A Gene

Domains for SV2A Gene

Protein Domains for SV2A Gene

Suggested Antigen Peptide Sequences for SV2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L0J3

UniProtKB/Swiss-Prot:

SV2A_HUMAN :
  • Q7L0J3
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with SV2A: view

No data available for Gene Families for SV2A Gene

Function for SV2A Gene

Molecular function for SV2A Gene

UniProtKB/Swiss-Prot Function: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).

Gene Ontology (GO) - Molecular Function for SV2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005215 transporter activity --
GO:0005515 protein binding --
GO:0019901 protein kinase binding ISS --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SV2A: view
genes like me logo Genes that share phenotypes with SV2A: view

Animal Models for SV2A Gene

MGI Knock Outs for SV2A:

Animal Model Products

CRISPR Products

miRNA for SV2A Gene

miRTarBase miRNAs that target SV2A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SV2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SV2A Gene

Localization for SV2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SV2A Gene

Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals. {ECO:0000250 UniProtKB:Q02563, ECO:0000250 UniProtKB:Q9JIS5}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SV2A Gene COMPARTMENTS Subcellular localization image for SV2A gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 3
plasma membrane 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for SV2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
GO:0008021 synaptic vesicle TAS 15217342
genes like me logo Genes that share ontologies with SV2A: view

Pathways for SV2A Gene

SuperPathways for SV2A Gene

Superpath Contained pathways
1 Focal adhesion
genes like me logo Genes that share pathways with SV2A: view

Pathways by source for SV2A Gene

1 KEGG pathway for SV2A Gene

Interacting Proteins for SV2A Gene

Gene Ontology (GO) - Biological Process for SV2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006836 neurotransmitter transport IEA --
GO:0006874 cellular calcium ion homeostasis IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SV2A: view

Compounds for SV2A Gene

(5) Tocris Compounds for SV2A Gene

Compound Action Cas Number
Brefeldin A Disrupts protein translocation to Golgi [20350-15-6]
DBeQ Selective and reversible p97 inhibitor [177355-84-9]
Eeyarestatin I Potent inhibitor of ER-associated protein degradation and translocation [412960-54-4]
Exo1 Inhibits Golgi-ER traffic; blocks exocytosis [461681-88-9]
Leptomycin B Inhibits nuclear export of proteins; antitumor [87081-35-4]

(1) HMDB Compounds for SV2A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for SV2A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Levetiracetam
  • Levetiracetam [INN]
102767-28-2 target agonist

(7) Novoseek inferred chemical compound relationships for SV2A Gene

Compound -log(P) Hits PubMed IDs
levetiracetam 81.5 24
gaba 9 1
acetylcholine 3.4 1
calcium 0 9
tyrosine 0 2
genes like me logo Genes that share compounds with SV2A: view

Transcripts for SV2A Gene

mRNA/cDNA for SV2A Gene

Unigene Clusters for SV2A Gene

Synaptic vesicle glycoprotein 2A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SV2A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SV2A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2:
SP3:
SP4: -
SP5: - -

Relevant External Links for SV2A Gene

GeneLoc Exon Structure for
SV2A
ECgene alternative splicing isoforms for
SV2A

Expression for SV2A Gene

mRNA expression in normal human tissues for SV2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SV2A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.8), Brain - Anterior cingulate cortex (BA24) (5.2), Brain - Cortex (5.0), Brain - Cerebellum (4.2), and Brain - Cerebellar Hemisphere (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SV2A Gene

SOURCE GeneReport for Unigene cluster for SV2A Gene Hs.516153

genes like me logo Genes that share expressions with SV2A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SV2A Gene

Orthologs for SV2A Gene

This gene was present in the common ancestor of animals.

Orthologs for SV2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SV2A 35
  • 99.78 (n)
  • 99.87 (a)
SV2A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SV2A 35
  • 92.63 (n)
  • 99.06 (a)
SV2A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SV2A 35
  • 91.87 (n)
  • 98.11 (a)
SV2A 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sv2a 35
  • 90.48 (n)
  • 98.92 (a)
Sv2a 16
Sv2a 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SV2A 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SV2A 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sv2a 35
  • 90.97 (n)
  • 98.79 (a)
chicken
(Gallus gallus)
Aves SV2A 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sv2a 35
  • 74.76 (n)
  • 83.81 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC568033 35
  • 72.5 (n)
  • 80.3 (a)
SV2A 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12783 36
  • 18 (a)
ManyToMany
CG14691 36
  • 20 (a)
ManyToMany
CG15221 36
  • 21 (a)
ManyToMany
CG31103 36
  • 21 (a)
ManyToMany
CG31106 36
  • 22 (a)
ManyToMany
CG31272 36
  • 21 (a)
ManyToMany
CG3168 36
  • 27 (a)
ManyToMany
CG33233 36
  • 18 (a)
ManyToMany
CG33234 36
  • 19 (a)
ManyToMany
CG3690 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for SV2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SV2A Gene

ENSEMBL:
Gene Tree for SV2A (if available)
TreeFam:
Gene Tree for SV2A (if available)

Paralogs for SV2A Gene

Paralogs for SV2A Gene

Selected SIMAP similar genes for SV2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SV2A: view

Variants for SV2A Gene

Sequence variations from dbSNP and Humsavar for SV2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13067 -- 149,905,113(-) GGAAT(C/T)ACCAA reference, synonymous-codon
rs530023 -- 149,916,260(+) GCAGG(A/G)AAGCC intron-variant
rs577935 -- 149,914,031(+) AGGAA(A/G)GAGAG utr-variant-5-prime
rs610976 -- 149,919,374(+) ATAAG(A/C)AGCCA upstream-variant-2KB
rs626785 -- 149,910,348(+) TGGGT(A/G)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SV2A Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
esv2750807 CNV Gain 17911159
dgv123e1 CNV Complex 17122850
dgv125e1 CNV Complex 17122850
nsv831525 CNV Gain 17160897
essv23032 CNV CNV 17122850
nsv831537 CNV Loss 17160897
nsv508037 CNV Loss 20534489

Relevant External Links for SV2A Gene

HapMap Linkage Disequilibrium report
SV2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SV2A Gene

Disorders for SV2A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SV2A Gene including...

Search for SV2A Gene in MalaCards »

(1) University of Copenhagen DISEASES for SV2A Gene

(8) Novoseek inferred disease relationships for SV2A Gene

Disease -log(P) Hits PubMed IDs
epilepsy 42.4 12
gastrointestinal stromal tumor 40.3 2
carcinoid 28.5 2
alzheimers disease 2.05 1
adenocarcinoma 0 2

Relevant External Links for SV2A

Genetic Association Database (GAD)
SV2A
Human Genome Epidemiology (HuGE) Navigator
SV2A
genes like me logo Genes that share disorders with SV2A: view

No data available for UniProtKB/Swiss-Prot for SV2A Gene

Publications for SV2A Gene

  1. No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy. (PMID: 18977120) Lynch J.M. … Sisodiya S.M. (Epilepsy Res. 2009) 3 23 48
  2. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. (PMID: 15210974) Lynch B.A. … Fuks B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 25
  3. Synaptic vesicle protein 2 binds adenine nucleotides. (PMID: 18524768) Yao J. … Bajjalieh S.M. (J. Biol. Chem. 2008) 3 23
  4. Expression patterns of synaptic vesicle protein 2A in focal cortical dysplasia and TSC-cortical tubers. (PMID: 19220410) Toering S.T. … Aronica E. (Epilepsia 2009) 3 23
  5. Botulinum toxin type A inhibits the growth of LNCaP human prostate cancer cells in vitro and in vivo. (PMID: 19399787) Karsenty G. … Corcos J. (Prostate 2009) 3 23

Products for SV2A Gene

Sources for SV2A Gene

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