Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SV2A Gene

Aliases for SV2A Gene

  • Synaptic Vesicle Glycoprotein 2A 2 3 5
  • KIAA0736 4
  • SV2 3

External Ids for SV2A Gene

Previous GeneCards Identifiers for SV2A Gene

  • GC01M145617
  • GC01M146649
  • GC01M147091
  • GC01M146688
  • GC01M148141
  • GC01M149874
  • GC01M121255

Summaries for SV2A Gene

GeneCards Summary for SV2A Gene

SV2A (Synaptic Vesicle Glycoprotein 2A) is a Protein Coding gene. Diseases associated with SV2A include Photosensitive Epilepsy and Reflex Epilepsy. Among its related pathways are Uptake and actions of bacterial toxins and Infectious disease. GO annotations related to this gene include protein kinase binding and transporter activity. An important paralog of this gene is SV2C.

UniProtKB/Swiss-Prot for SV2A Gene

  • Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).

Tocris Summary for SV2A Gene

  • Once proteins are translated, they must be directed to the appropriate localization within, or outside of the cell. Protein translocation occurs either during translation or after translation and depends on the N'-terminal signal-recognition particle (SRP) interacting with its receptor.

Gene Wiki entry for SV2A Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SV2A Gene

Genomics for SV2A Gene

Regulatory Elements for SV2A Gene

Enhancers for SV2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SV2A on UCSC Golden Path with GeneCards custom track

Promoters for SV2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SV2A on UCSC Golden Path with GeneCards custom track

Genomic Location for SV2A Gene

149,903,318 bp from pter
149,917,882 bp from pter
14,565 bases
Minus strand

Genomic View for SV2A Gene

Genes around SV2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SV2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SV2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SV2A Gene

Proteins for SV2A Gene

  • Protein details for SV2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synaptic vesicle glycoprotein 2A
    Protein Accession:
    Secondary Accessions:
    • D3DUZ7
    • O94841
    • Q5QNX8
    • Q7Z3L6
    • Q8NBJ6
    • Q9BVZ9

    Protein attributes for SV2A Gene

    742 amino acids
    Molecular mass:
    82695 Da
    Quaternary structure:
    • Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2 (By similarity).
    • Identified as the brain binding-site for the antiepileptic drug levetiracetam/lev.
    • Sequence=BAA34456.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12573.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SV2A Gene

    Alternative splice isoforms for SV2A Gene


neXtProt entry for SV2A Gene

Proteomics data for SV2A Gene at MOPED

Post-translational modifications for SV2A Gene

  • N-glycosylated.
  • Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.
  • Ubiquitination at Lys 366, Lys 375, and Lys 515
  • Glycosylation at Asn 498, Asn 548, and Asn 573
  • Modification sites at PhosphoSitePlus

Other Protein References for SV2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SV2A Gene

Domains & Families for SV2A Gene

Protein Domains for SV2A Gene

Suggested Antigen Peptide Sequences for SV2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily.
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with SV2A: view

No data available for Gene Families for SV2A Gene

Function for SV2A Gene

Molecular function for SV2A Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).

Gene Ontology (GO) - Molecular Function for SV2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
genes like me logo Genes that share ontologies with SV2A: view
genes like me logo Genes that share phenotypes with SV2A: view

Animal Models for SV2A Gene

MGI Knock Outs for SV2A:

Animal Model Products

miRNA for SV2A Gene

miRTarBase miRNAs that target SV2A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SV2A Gene

Localization for SV2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SV2A Gene

Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals. {ECO:0000250 UniProtKB:Q02563, ECO:0000250 UniProtKB:Q9JIS5}.

Subcellular locations from

Jensen Localization Image for SV2A Gene COMPARTMENTS Subcellular localization image for SV2A gene
Compartment Confidence
plasma membrane 3
cytosol 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for SV2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0008021 synaptic vesicle TAS 15217342
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with SV2A: view

Pathways & Interactions for SV2A Gene

genes like me logo Genes that share pathways with SV2A: view

Pathways by source for SV2A Gene

Interacting Proteins for SV2A Gene

Gene Ontology (GO) - Biological Process for SV2A Gene


No data available for SIGNOR curated interactions for SV2A Gene

Drugs & Compounds for SV2A Gene

(14) Drugs for SV2A Gene - From: DrugBank, ClinicalTrials, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Levetiracetam Approved, Investigational Pharma blocker, Target, agonist Antiepileptic; binds SV2A 0
calcium Nutra 0
Anticonvulsants Pharma 2521
Etiracetam Pharma 197
Neuroprotective Agents Pharma 1604

(6) Additional Compounds for SV2A Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
leptomycin b

(5) Tocris Compounds for SV2A Gene

Compound Action Cas Number
Brefeldin A Disrupts protein translocation to Golgi 20350-15-6
D15 Endocytosis blocker 251939-41-0
Exo1 Inhibits Golgi-ER traffic; blocks exocytosis 461681-88-9
Leptomycin B Inhibits nuclear export of proteins; antitumor 87081-35-4
Levetiracetam Antiepileptic; binds SV2A 102767-28-2
genes like me logo Genes that share compounds with SV2A: view

Transcripts for SV2A Gene

mRNA/cDNA for SV2A Gene

Unigene Clusters for SV2A Gene

Synaptic vesicle glycoprotein 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SV2A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP4: -
SP5: - -

Relevant External Links for SV2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SV2A Gene

mRNA expression in normal human tissues for SV2A Gene

mRNA differential expression in normal tissues according to GTEx for SV2A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Cortex (x5.0), Brain - Cerebellum (x4.2), and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for SV2A Gene

This gene is overexpressed in Frontal cortex (31.1) and Brain (27.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SV2A Gene

SOURCE GeneReport for Unigene cluster for SV2A Gene Hs.516153

genes like me logo Genes that share expression patterns with SV2A: view

Protein tissue co-expression partners for SV2A Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SV2A Gene

Orthologs for SV2A Gene

This gene was present in the common ancestor of animals.

Orthologs for SV2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SV2A 35
  • 92.63 (n)
  • 99.06 (a)
SV2A 36
  • 99 (a)
(Canis familiaris)
Mammalia SV2A 35
  • 91.87 (n)
  • 98.11 (a)
SV2A 36
  • 79 (a)
(Mus musculus)
Mammalia Sv2a 35
  • 90.48 (n)
  • 98.92 (a)
Sv2a 16
Sv2a 36
  • 99 (a)
(Pan troglodytes)
Mammalia SV2A 35
  • 99.78 (n)
  • 99.87 (a)
SV2A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sv2a 35
  • 90.97 (n)
  • 98.79 (a)
(Monodelphis domestica)
Mammalia SV2A 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia SV2A 36
  • 52 (a)
(Gallus gallus)
Aves SV2A 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sv2a 35
  • 74.76 (n)
  • 83.81 (a)
(Danio rerio)
Actinopterygii LOC568033 35
  • 72.5 (n)
  • 80.3 (a)
SV2A 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12783 36
  • 18 (a)
CG14691 36
  • 20 (a)
CG15221 36
  • 21 (a)
CG31103 36
  • 21 (a)
CG31106 36
  • 22 (a)
CG31272 36
  • 21 (a)
CG3168 36
  • 27 (a)
CG33233 36
  • 18 (a)
CG33234 36
  • 19 (a)
CG3690 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for SV2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SV2A Gene

Gene Tree for SV2A (if available)
Gene Tree for SV2A (if available)

Paralogs for SV2A Gene

Paralogs for SV2A Gene

(2) SIMAP similar genes for SV2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SV2A: view

Variants for SV2A Gene

Sequence variations from dbSNP and Humsavar for SV2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs13067 -- 149,905,113(-) GGAAT(C/T)ACCAA reference, synonymous-codon
rs530023 -- 149,916,260(+) GCAGG(A/G)AAGCC intron-variant
rs610976 -- 149,919,374(+) ATAAG(A/C)AGCCA upstream-variant-2KB
rs577935 -- 149,914,031(+) AGGAA(A/G)GAGAG utr-variant-5-prime
rs626785 -- 149,910,348(+) TGGGT(A/G)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SV2A Gene

Variant ID Type Subtype PubMed ID
dgv117e1 CNV Complex 17122850
nsv428235 CNV Gain 18775914
esv2750807 CNV Gain 17911159
dgv123e1 CNV Complex 17122850
dgv125e1 CNV Complex 17122850
nsv831525 CNV Gain 17160897
essv23032 CNV CNV 17122850
nsv831537 CNV Loss 17160897
nsv508037 CNV Loss 20534489

Variation tolerance for SV2A Gene

Residual Variation Intolerance Score: 4.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SV2A Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SV2A Gene

Disorders for SV2A Gene

MalaCards: The human disease database

(3) MalaCards diseases for SV2A Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
photosensitive epilepsy
  • photoparoxysmal response 1
reflex epilepsy
  • epilepsy, sensory-induced
epilepsy syndrome
  • epilepsy
- elite association - COSMIC cancer census association via MalaCards
Search SV2A in MalaCards View complete list of genes associated with diseases

Relevant External Links for SV2A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SV2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SV2A Gene

Publications for SV2A Gene

  1. No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy. (PMID: 18977120) Lynch J.M. … Sisodiya S.M. (Epilepsy Res. 2009) 3 23 48 67
  2. Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein. (PMID: 16556440) Gillard M. … Fuks B. (Eur. J. Pharmacol. 2006) 23 25 26
  3. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. (PMID: 15210974) Lynch B.A. … Fuks B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 25 26
  4. Expression of synaptic vesicle protein 2A in epilepsy-associated brain tumors and in the peritumoral cortex. (PMID: 20167814) de Groot M. … Reijneveld J.C. (Neuro-oncology 2010) 3 23
  5. Expression patterns of synaptic vesicle protein 2A in focal cortical dysplasia and TSC-cortical tubers. (PMID: 19220410) Toering S.T. … Aronica E. (Epilepsia 2009) 3 23

Products for SV2A Gene

Sources for SV2A Gene