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Aliases for SUZ12 Gene

Aliases for SUZ12 Gene

  • SUZ12 Polycomb Repressive Complex 2 Subunit 2 3
  • JJAZ1 3 4 6
  • Chromatin Precipitated E2F Target 9 Protein 3 4
  • Suppressor Of Zeste 12 Protein Homolog 3 4
  • Joined To JAZF1 Protein 3 4
  • ChET 9 Protein 3 4
  • KIAA0160 4 6
  • CHET9 3 4
  • Suppressor Of Zeste 12 Homolog (Drosophila) 2
  • Suppressor Of Zeste 12 Homolog 3
  • Polycomb Protein SUZ12 3

External Ids for SUZ12 Gene

Previous GeneCards Identifiers for SUZ12 Gene

  • GC17P027289
  • GC17P030264

Summaries for SUZ12 Gene

Entrez Gene Summary for SUZ12 Gene

  • This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]

GeneCards Summary for SUZ12 Gene

SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit) is a Protein Coding gene. Diseases associated with SUZ12 include endometrial stromal tumor. Among its related pathways are Cellular Senescence and Chromatin Regulation / Acetylation. GO annotations related to this gene include sequence-specific DNA binding and methylated histone binding.

UniProtKB/Swiss-Prot for SUZ12 Gene

  • Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates Lys-9 (H3K9me) and Lys-27 (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

Gene Wiki entry for SUZ12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUZ12 Gene

Genomics for SUZ12 Gene

Genomic Location for SUZ12 Gene

Start:
31,937,018 bp from pter
End:
32,001,045 bp from pter
Size:
64,028 bases
Orientation:
Plus strand

Genomic View for SUZ12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUZ12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUZ12 Gene

No data available for Regulatory Elements for SUZ12 Gene

Proteins for SUZ12 Gene

  • Protein details for SUZ12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15022-SUZ12_HUMAN
    Recommended name:
    Polycomb protein SUZ12
    Protein Accession:
    Q15022
    Secondary Accessions:
    • Q96BD9

    Protein attributes for SUZ12 Gene

    Size:
    739 amino acids
    Molecular mass:
    83055 Da
    Quaternary structure:
    • Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with WDR77. Interacts with histone H1. Interacts with CDYL. Interacts with ARNTL/BMAL1.
    Miscellaneous:
    • Under hypoxic conditions, the precursor SUZ12 RNA undergoes regulated trans-splicing with the JAZF1 RNA, resulting in a chimeric isoform which may be protective against apoptosis. The chimeric transcript is characterized by JAZF1 exons 1-3 joined to SUZ12 exon 2-16. The chimeric transcript is expressed primarily in the endometrium from late secretory and early proliferative phases of the menstrual cycle, but not in normal myometrium at any phase of the cycle. Its expression is slightly induced by low levels of progesterone, but suppressed by both estrogen and high levels of progesterone (PubMed:18772439).
    SequenceCaution:
    • Sequence=BAA09931.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SUZ12 Gene

Proteomics data for SUZ12 Gene at MOPED

Post-translational modifications for SUZ12 Gene

Other Protein References for SUZ12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SUZ12 Gene

Domains for SUZ12 Gene

Gene Families for SUZ12 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for SUZ12 Gene

Suggested Antigen Peptide Sequences for SUZ12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15022

UniProtKB/Swiss-Prot:

SUZ12_HUMAN :
  • Q15022
Family:
  • Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with SUZ12: view

Function for SUZ12 Gene

Molecular function for SUZ12 Gene

UniProtKB/Swiss-Prot Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates Lys-9 (H3K9me) and Lys-27 (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
UniProtKB/Swiss-Prot Induction: Expression is induced by E2F1, E2F2 and E2F3.

Gene Ontology (GO) - Molecular Function for SUZ12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 17560333
GO:0035064 methylated histone binding IDA 21029866
GO:0042054 histone methyltransferase activity IMP 15385962
genes like me logo Genes that share ontologies with SUZ12: view
genes like me logo Genes that share phenotypes with SUZ12: view

Animal Models for SUZ12 Gene

MGI Knock Outs for SUZ12:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SUZ12 Gene

Localization for SUZ12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUZ12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUZ12 Gene COMPARTMENTS Subcellular localization image for SUZ12 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SUZ12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001739 sex chromatin IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0035098 ESC/E(Z) complex IMP 15385962
genes like me logo Genes that share ontologies with SUZ12: view

Pathways for SUZ12 Gene

genes like me logo Genes that share pathways with SUZ12: view

Pathways by source for SUZ12 Gene

1 Cell Signaling Technology pathway for SUZ12 Gene

Gene Ontology (GO) - Biological Process for SUZ12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SUZ12: view

Compounds for SUZ12 Gene

(1) Novoseek inferred chemical compound relationships for SUZ12 Gene

Compound -log(P) Hits PubMed IDs
zinc 16.5 1
genes like me logo Genes that share compounds with SUZ12: view

Transcripts for SUZ12 Gene

Unigene Clusters for SUZ12 Gene

Suppressor of zeste 12 homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUZ12 Gene

No ASD Table

Relevant External Links for SUZ12 Gene

GeneLoc Exon Structure for
SUZ12
ECgene alternative splicing isoforms for
SUZ12

Expression for SUZ12 Gene

mRNA expression in normal human tissues for SUZ12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUZ12 Gene

SOURCE GeneReport for Unigene cluster for SUZ12 Gene Hs.462732

mRNA Expression by UniProt/SwissProt for SUZ12 Gene

Q15022-SUZ12_HUMAN
Tissue specificity: Overexpressed in breast and colon cancer.
genes like me logo Genes that share expressions with SUZ12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SUZ12 Gene

Orthologs for SUZ12 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUZ12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUZ12 35
  • 99.82 (n)
  • 99.46 (a)
SUZ12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUZ12 35
  • 95.9 (n)
  • 99.19 (a)
SUZ12 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUZ12 35
  • 96.48 (n)
  • 99.05 (a)
SUZ12 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Suz12 35
  • 92.91 (n)
  • 97.62 (a)
Suz12 16
Suz12 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUZ12 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUZ12 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC688041 35
  • 92.15 (n)
  • 94.73 (a)
chicken
(Gallus gallus)
Aves SUZ12 35
  • 86.22 (n)
  • 94.78 (a)
SUZ12 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUZ12 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8479 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1012 35
suz12 35
  • 77.5 (n)
  • 87.03 (a)
zebrafish
(Danio rerio)
Actinopterygii suz12a 36
  • 73 (a)
OneToMany
suz12b 35
  • 71.79 (n)
  • 78.96 (a)
suz12b 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Su(z)12 35
  • 49.53 (n)
  • 45.1 (a)
Su(z)12 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for SUZ12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUZ12 Gene

ENSEMBL:
Gene Tree for SUZ12 (if available)
TreeFam:
Gene Tree for SUZ12 (if available)

Paralogs for SUZ12 Gene

Pseudogenes.org Pseudogenes for SUZ12 Gene

genes like me logo Genes that share paralogs with SUZ12: view

No data available for Paralogs for SUZ12 Gene

Variants for SUZ12 Gene

Sequence variations from dbSNP and Humsavar for SUZ12 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs10627 -- 32,000,300(+) ATTTT(A/G)TTTAA utr-variant-3-prime
rs15654 -- 31,999,341(-) AGCCG(G/T)TCATA utr-variant-3-prime
rs472745 -- 31,985,280(+) TCACA(A/G)TGTAG intron-variant
rs473342 -- 31,973,872(-) AGTGA(C/T)TGAGG intron-variant
rs473356 -- 31,994,743(+) TATAA(C/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUZ12 Gene

Variant ID Type Subtype PubMed ID
dgv944e1 CNV Complex 17122850
nsv908065 CNV Loss 21882294
nsv2025 CNV Loss 18451855
nsv908066 CNV Gain 21882294
nsv908067 CNV Gain 21882294
esv2678272 CNV Deletion 23128226
esv2665285 CNV Deletion 23128226

Relevant External Links for SUZ12 Gene

HapMap Linkage Disequilibrium report
SUZ12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUZ12 Gene

Disorders for SUZ12 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SUZ12 Gene including...

Search for SUZ12 Gene in MalaCards »

UniProtKB/Swiss-Prot

SUZ12_HUMAN
  • Note=A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. {ECO:0000269 PubMed:11371647}.

(1) University of Copenhagen DISEASES for SUZ12 Gene

(3) Novoseek inferred disease relationships for SUZ12 Gene

Disease -log(P) Hits PubMed IDs
sarcoma endometrial stromal 76.5 1
stromal tumors 69 3
tumors 19.5 4
genes like me logo Genes that share disorders with SUZ12: view

Publications for SUZ12 Gene

  1. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. (PMID: 11371647) Koontz J.I. … Sklar J. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 23
  2. The polycomb repressive complex 2 is a potential target of SUMO modifications. (PMID: 18628979) Riising E.M. … Pasini D. (PLoS ONE 2008) 3 4 23
  3. A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells. (PMID: 18772439) Li H. … Sklar J. (Science 2008) 3 4 23
  4. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  5. Use of chromatin immunoprecipitation to clone novel E2F target promoters. (PMID: 11564866) Weinmann A.S. … Farnham P.J. (Mol. Cell. Biol. 2001) 3 4

Products for SUZ12 Gene

  • Addgene plasmids for SUZ12

Sources for SUZ12 Gene

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