Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SUZ12 Gene

protein-coding GIFtS: 55
GCID: GC17P030264

suppressor of zeste 12 homolog (Drosophila)

Explore 23 diseases affiliated with
SUZ12 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Suppressor Of Zeste 12 Homolog (Drosophila)¹ ²		Chromatin Precipitated E2F Target 9 Protein² ³
JJAZ1¹ ² ³ ⁵		Joined To JAZF1 Protein² ³
CHET9¹ ² ³		Suppressor Of Zeste 12 Protein Homolog² ³
KIAA0160¹ ³ ⁵		Polycomb Protein SUZ12²
ChET 9 Protein² ³

External Ids:	HGNC: 17101¹	Entrez Gene: 23512²	Ensembl: ENSG00000178691⁷	OMIM: 606245⁵	UniProtKB: Q15022³

Export aliases for SUZ12 gene to outside databases

Previous GC identifer: GC17P027289

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUZ12:

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in

endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The

protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. (provided by

RefSeq, Jul 2009)

UniProtKB/Swiss-Prot: SUZ12_HUMAN, Q15022

Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and

'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2

complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression

systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A

Gene Wiki entry for SUZ12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SUZ12
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SUZ12 promoter sequence

Search SABiosciences Chromatin IP Primers for SUZ12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUZ12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q21

SUZ12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUZ12 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P030264: view genomic region (about GC identifiers)

Start:	30,264,037 bp from pter	End:	30,328,064 bp from pter
Size:	64,028 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SUZ12_HUMAN, Q15022 (See protein sequence)

Recommended Name: Polycomb protein SUZ12

Size: 739 amino acids; 83055 Da

Subunit: Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2.

The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12.

Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also

interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with

WDR77. Interacts with histone H1

Subcellular location: Nucleus

Developmental stage: Expressed at low levels in quiescent cells. Expression rises at the G1/S phase transition

Miscellaneous: Under hypoxic conditions, the precursor SUZ12 RNA undergoes regulated trans-splicing with the JAZF1 RNA,

resulting in a chimeric isoform which may be protective against apoptosis. The chimeric transcript is characterized by

JAZF1 exons 1-3 joined to SUZ12 exon 2-16. The chimeric transcript is expressed primarily in the endometrium from late

secretory and early proliferative phases of the menstrual cycle, but not in normal myometrium at any phase of the

cycle. Its expression is slightly induced by low levels of progesterone, but suppressed by both estrogen and high

levels of progesterone (PubMed:18772439)

Caution: Two variants of the PRC2 complex have been described, termed PRC3 and PRC4. Each of the three complexes may

include a different complement of EED isoforms, although the precise sequences of the isoforms in each complex have

not been determined. The PRC2 and PRC4 complexes may also methylate 'Lys-26' of histone H1 in addition to 'Lys-27' of

histone H3 (PubMed:15099518 and PubMed:15684044), although other studies have demonstrated no methylation of 'Lys-26'

of histone H1 by PRC2 (PubMed:16431907)

Sequence caution: Sequence=BAA09931.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: Q96BD9

Explore the universe of human proteins at neXtProt for SUZ12: NX_Q15022

Post-translational modifications:

Sumoylated, probably by PIAS2¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15022

SUZ12 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_056170.2

ENSEMBL proteins:

ENSP00000316578 ENSP00000463936

Human Recombinant Protein Products for SUZ12:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SUZ12 OriGene Protein Over-expression Lysate: SUZ12 OriGene Custom Protein Services for SUZ12
	GenScript Custom Purified and Recombinant Proteins Services for SUZ12
	Novus Biologicals SUZ12 Protein Novus Biologicals SUZ12 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SUZ12

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001739	sex chromatin	IEA	--
GO:0005634	nucleus	--	--
GO:0035098	ESC/E(Z) complex	IMP	15385962

SUZ12 for ontologies About GeneDecksing

SUZ12 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SUZ12
	R&D Systems Antibodies for SUZ12
	Cell Signaling Technology (CST) Antibodies for SUZ12
	Browse OriGene Antibodies OriGene Custom Antibody Services for SUZ12
	GenScript Custom Superior Antibodies Services for SUZ12
	Novus Biologicals SUZ12 Antibodies
	Abcam antibodies for SUZ12
	Uscn Antibodies for SUZ12
	ThermoFisher Antibody for SUZ12

Assay Products for SUZ12:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SUZ12
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SUZ12

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SUZ12 for domains About GeneDecksing

2 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR019135 Polycomb_protein_VEFS-Box

Graphical View of Domain Structure for InterPro Entry Q15022

ProtoNet protein and cluster: Q15022

UniProtKB/Swiss-Prot: SUZ12_HUMAN, Q15022

Similarity: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family

Similarity: Contains 1 C2H2-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SUZ12_HUMAN, Q15022

Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and

'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2

complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression

systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A

Induction: Expression is induced by E2F1, E2F2 and E2F3

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0008270	zinc ion binding	IEA	--
GO:0035064	methylated histone residue binding	IDA	--
GO:0042054	histone methyltransferase activity	IMP	15385962

SUZ12 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for SUZ12:

Increased homologous recombina

Synthetic lethal with Ras

9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Suz12):

behavior/neurological	cellular	embryogenesis	growth/size	hematopoietic system
immune system	mortality/aging	nervous system	skeleton

SUZ12 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Suz12^tm1Hko for SUZ12

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SUZ12

miRNA Products:		miRTarBase miRNAs that target SUZ12: hsa-mir-101 (MIRT004084)

		OriGene 3'-UTR Clone: SUZ12 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUZ12
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate SUZ12 (see all 62):
		hsa-miR-607 hsa-miR-642a hsa-miR-3146 hsa-miR-429 hsa-miR-188-5p hsa-miR-15a hsa-miR-199a-3p hsa-miR-128

		SwitchGear 3'UTR luciferase reporter plasmid: SUZ12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUZ12 (see all 4) OriGene shRNA RFP: SUZ12 OriGene siRNA: SUZ12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUZ12
		Sirion Biotech Custom design and validation of potent shRNA sequences against SUZ12

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SUZ12
			Sirion Biotech Customized adenovirus for overexpression of SUZ12 Sirion Biotech Customized adenovirus for potent knockdown of SUZ12

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUZ12 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUZ12 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SUZ12 (NM_015355)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUZ12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUZ12

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SUZ12
		Search LifeMap BioReagents cell lines for SUZ12
		Sirion Biotech Customized stable knockdown cell line services for SUZ12 Sirion Biotech Customized inducible knockdown cell line services for SUZ12 Sirion Biotech Customized stable overexpressing cell line services for SUZ12 Sirion Biotech Customized inducible overexpressing cell line services for SUZ12

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUZ12

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Selected targets of Oct-3/4

Selected targets of Oct-3/4

1.00

Signal transduction Activin A signaling regulation

Histone modification

0.31

GABA A receptor activation

GABA signaling in brain

0.26

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for SUZ12

	Selected targets of Oct-3/4
	Histone modification
	GABA signaling in brain

1 Cell Signaling Technology (CST) Pathway for SUZ12

Chromatin Regulation / Acetylation

SUZ12 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SUZ12

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/82 Interacting proteins for SUZ12 (Q15022^{1, 3} ENSP00000316578⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 82)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EED	O75530³, ENSP00000263360⁴	I2D: score=7 STRING: ENSP00000263360
EZH2	Q15910³, ENSP00000320147⁴	I2D: score=7 STRING: ENSP00000320147
MTF2	Q9Y483³, ENSP00000359321⁴	I2D: score=5 STRING: ENSP00000359321
RBBP4	Q09028³, ENSP00000362592⁴	I2D: score=4 STRING: ENSP00000362592
JARID2	Q92833³, ENSP00000341280⁴	I2D: score=3 STRING: ENSP00000341280

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0008284	positive regulation of cell proliferation	IEA	--
GO:0016571	histone methylation	--	--
GO:0016574	histone ubiquitination	IEA	--

SUZ12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SUZ12 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SUZ12
1 Novoseek chemical compound relationship for SUZ12 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	16.5	1	11371647 (1)

Search CenterWatch for drugs/clinical trials and news about SUZ12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SUZ12 gene:

NM_015355.2

Unigene Cluster for SUZ12:

Suppressor of zeste 12 homolog (Drosophila)

Hs.744174 [show with all ESTs]

Unigene Representative Sequence: NM_015355

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000322652(uc002hgs.2 uc002hgt.2) ENST00000580398 ENST00000494429

ENST00000578106

miRNA Products:		OriGene 3'-UTR Clone: SUZ12 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUZ12
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate SUZ12 (see all 62):
		hsa-miR-607 hsa-miR-642a hsa-miR-3146 hsa-miR-429 hsa-miR-188-5p hsa-miR-15a hsa-miR-199a-3p hsa-miR-128

		SwitchGear 3'UTR luciferase reporter plasmid: SUZ12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUZ12 (see all 4) OriGene shRNA RFP: SUZ12 OriGene siRNA: SUZ12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUZ12
		Sirion Biotech Custom design and validation of potent shRNA sequences against SUZ12

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUZ12 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUZ12 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SUZ12 (NM_015355)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUZ12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUZ12

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUZ12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SUZ12
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUZ12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUZ12

Additional cDNA sequence:

AK024514.1 AK074333.1 AK290014.1 BC015704.1 BC018583.1 D63881.2

15 DOTS entries:

DT.100668202 DT.448332 DT.91972932 DT.120955581 DT.91741284 DT.97820937 DT.100038518 DT.120955552

DT.120955590 DT.120955614 DT.86853104 DT.91741280 DT.91796145 DT.117872 DT.97816676

24/225 AceView cDNA sequences (see all 225):

BM788011 AA336615 BM973879 BQ188256 AW779294 BQ437791 AI292053 AA328653

CB069329 BE256205 NM_015355 AA164915 BQ631743 AI700794 BQ632197 BM676331

BE044427 AU139312 AI888036 D63881 BQ023135 BU684249 BC018583 BM677756

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SUZ12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAGAATAT

About this image

SUZ12 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Cap Mesenchyme

Cap Mesenchyme Cells

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SUZ12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SUZ12

SOURCE GeneReport for Unigene cluster: Hs.744174

UniProtKB/Swiss-Prot: SUZ12_HUMAN, Q15022

Tissue specificity: Overexpressed in breast and colon cancer

SABiosciences Expression via Pathway-Focused PCR Array including SUZ12:

Epigenetic Chromatin Remodeling Factors in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUZ12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SUZ12
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUZ12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUZ12

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUZ12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUZ12 gene from 8/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Suz12^{1 , 5}	suppressor of zeste 12 homolog (Drosophila)^{1, 5}	93.01(n)¹ 97.16(a)¹		11 (47.36 cM)⁵ 52615¹ NM_199196.2¹ NP_954666.1¹ 79993106⁵
chicken (Gallus gallus)	Aves	SUZ12¹	suppressor of zeste 12 homolog (Drosophila)	84.39(n) 92.96(a)		417406 XM_415658.3 XP_415658.2
lizard (Anolis carolinensis)	Reptilia	SUZ12⁶	--	88(a)	1 ↔ 1	GL343198.1(1446375-1476006)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8479²	Xenopus laevis transcribed sequence with moderate similarity more	79.2(n)		BU909540.1
zebrafish (Danio rerio)	Actinopterygii	BM775706.1²	--	74.2(n)		BM775706.1
fruit fly (Drosophila melanogaster)	Insecta	Su(z)12¹	CG8013-PA	48.77(n) 44.13(a)		48071 NM_168826.1 NP_730465.1
thale cress (Arabidopsis thaliana)	eudicotyledons	VRN2⁶ AtEMF2⁶ (see all 4)	polycomb group protein EMBRYONIC FLOWER 2 (see all 4)	20(a) 15(a) (see all 4)	many → 1 many → 1 (see all 4)	4(9476143-9479878) 5(20823736-20829564)
rice (Oryza sativa)	Liliopsida	-- --	ZOS4-02 - C2H2 zinc finger protein, expressed	16(a) 14(a)	many → 1 many → 1	9(7924560-7937161) 4(4270491-4286303)

ENSEMBL Gene Tree for SUZ12 (if available)
TreeFam Gene Tree for SUZ12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SUZ12 gene

SUZ12 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for SUZ12
PGOHUM00000248111 PGOHUM00000237350

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7212095^1,2	C	--	26472276(+)	`gggctC/Tcagag`	1	--	us2k¹		0	--	--	--	--
rs78096293^1,2	F	--	26472365(+)	`AGATAT/CTAATA`	1	--	us2k¹		1		WA	118
rs79424734^1,2	F	--	26472407(+)	`TGAATG/CTTAAG`	1	--	us2k¹		1		EA	120
rs8074025^1,2	C,F	--	26472517(+)	`ACTCAT/CTGGAT`	1	--	us2k¹		1		WA	118
rs55643307^1,2	C	--	26473210(+)	`GTGTTT/CTGCAG`	1	--	us2k¹		2		NA	122
rs75794186^1,2	F	--	26473353(+)	`TTGTCC/GAACCT`	1	--	us2k¹		1		NA	120
rs7217880^1,2	C,F,H	--	26473429(+)	`TCTATC/TGTTCA`	1	--	us2k¹		7		NS NA	888
rs112713443^1,2		--	26473829(+)	`AAGTAG/CTTCTC`	1	--	us2k¹		1		CSA	1
rs55693529^1,2	C	--	26473887(+)	`ACTAAG/CGATCT`	1	--	us2k¹		1		WA	2
rs12600783^1,2	C,F,H	--	26473950(+)	`CAGCAG/AGAAGG`	1	--	us2k¹		7		NS NA CA	704

HapMap Linkage Disequilibrium report for SUZ12 (30264037 - 30328064 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SUZ12
2 CNVs: 88422 4030

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SUZ12

DNA2.0 Custom Variant and Variant Library Synthesis for SUZ12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SUZ12 for disorders About GeneDecksing

OMIM gene information: 606245 OMIM disorders: --

UniProtKB/Swiss-Prot: SUZ12_HUMAN, Q15022

Note=A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation

t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of

JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in

endometrial stromal sarcomas, where it is rarer

20/23 diseases for SUZ12 (see all 23): About MalaCards

endometrial stromal sarcoma sarcoma ovarian sex cord tumors endometrial stromal tumor

congenital heart defect mantle cell lymphoma acute promyelocytic leukemia chronic myeloid leukemia

myeloid leukemia wilms tumor embryonal carcinoma teratocarcinoma

neurofibromatosis acute leukemia leukemia lung adenocarcinoma

colon cancer adenocarcinoma prostate cancer prostatitis

1 disease from the University of Copenhagen DISEASES database for SUZ12:

Endometrial stromal sarcoma

3 Novoseek disease relationships for SUZ12 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sarcoma endometrial stromal	76.5	1	15043312 (1)
stromal tumors	69	2	17667554 (1), 11371647 (1), 15043312 (1)
tumors	19.5	5	18984978 (2), 18753137 (1), 16049311 (1)

Export disorders for SUZ12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SUZ12 gene, integrated from 9 sources (see all 114):
(articles sorted by number of sources associating them with SUZ12)

Utopia: connect your pdf to the dynamic
world of online information

Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. (PubMed id 11371647)^{1, 2, 3, 9} Koontz J.I.... Sklar J. (2001)
Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)^{1, 2, 3} Nagase T....Nomura N. (1995)
The polycomb repressive complex 2 is a potential target of SUMO modifications. (PubMed id 18628979)^{1, 2, 9} Riising E.M....Pasini D. (2008)
A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells. (PubMed id 18772439)^{1, 2, 9} Li H....Sklar J. (2008)
Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development. (PubMed id 18784248)^{1, 3} Ross P.J....Cibelli J.B. (2008)
Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. (PubMed id 18285464)^{1, 2} Sarma K....Reinberg D. (2008)
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. (PubMed id 19026781)^{1, 2} Margueron R.... Reinberg D. (2008)
Substrate preferences of the EZH2 histone methyltransferase complex. (PubMed id 16431907)^{1, 2} Martin C.... Zhang Y. (2006)
Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. (PubMed id 16712789)^{1, 2} Furuno K.... Yamamoto K. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23512	HGNC: 17101	AceView: JJAZ1	Ensembl:ENSG00000178691	euGenes: HUgn23512
ECgene: SUZ12	H-InvDB: SUZ12

(According to HUGE)
About This Section

HUGE: KIAA0160

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SUZ12	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SUZ12	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SUZ12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SUZ12 gene:
Search GeneIP for patents involving SUZ12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	Browse Small Molecules at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of SUZ12

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for SUZ12 (SUZ12)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SUZ12
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUZ12		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUZ12
	OriGene Protein Over-expression Lysate for SUZ12		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SUZ12		OriGene 3'-UTR Clone for SUZ12
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUZ12		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUZ12
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for SUZ12		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SUZ12		OriGene Custom Protein Services for SUZ12
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SUZ12
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SUZ12
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUZ12
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUZ12
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUZ12
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUZ12

	GenScript Custom Purified and Recombinant Proteins Services for SUZ12		GenScript cDNA clones with any tag delivered in your preferred vector for SUZ12
	GenScript Custom Assay Services for SUZ12		GenScript Custom Superior Antibodies Services for SUZ12
	GenScript Custom overexpressing Cell Line Services for SUZ12		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for SUZ12

	Search Regulatory tfbs for SUZ12
	Search Chromatin IP Primers for SUZ12
	RT² qPCR Primer Assay in human, mouse, rat SUZ12
	GNC Network for SUZ12
	SABiosciences PCR Arrays including human, mouse, rat SUZ12

Search Tocris compounds for SUZ12

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SUZ12 antibodies
	SUZ12 proteins
	SUZ12 lysates

	Antibodies for SUZ12
	See all of Abcam's Antibodies, Kits and Proteins for SUZ12
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SUZ12 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SUZ12

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUZ12

	SwitchGear 3'UTR luciferase reporter plasmids for SUZ12
	SwitchGear Promoter luciferase reporter plasmids for SUZ12

ThermoFisher Antibody for SUZ12

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUZ12

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SUZ12

Sirion Biotech Customized:

	stable knockdown cell line services for SUZ12
	inducible knockdown cell line services for SUZ12
	design and validation of potent shRNA sequences against SUZ12
	adenovirus for potent knockdown of SUZ12
	adenovirus for overexpression of SUZ12
	stable overexpressing cell line services for SUZ12
	inducible overexpressing cell line services for SUZ12

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SUZ12 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

SUZ12 Gene

suppressor of zeste 12 homolog (Drosophila)

Aliases
for SUZ12 gene

Summaries
for SUZ12 gene

Genomic Views
for SUZ12 gene

Proteins
for SUZ12 gene

Protein Domains /
Families
for SUZ12 gene

Function
for SUZ12 gene

Pathways & Interactions
for SUZ12 gene

Drugs & Compounds
for SUZ12 gene

Transcripts
for SUZ12 gene

Expression
for SUZ12 gene

Orthologs
for SUZ12 gene

Paralogs
for SUZ12 gene

Genomic Variants
for SUZ12 gene

Disorders / Diseases
for SUZ12 gene

Publications
for SUZ12 gene

External Searches for SUZ12 gene

Genome Databases showing SUZ12 gene

Other Databases showing SUZ12 gene

Specialized Databases showing SUZ12 gene

Intellectual Property
for SUZ12 gene

Products
for SUZ12 gene

View Random Gene

Advanced Search

Export list of displayed genes

SUZ12 Gene

suppressor of zeste 12 homolog (Drosophila)

Aliasesfor SUZ12 gene

Summariesfor SUZ12 gene

Genomic Viewsfor SUZ12 gene

Proteinsfor SUZ12 gene

Protein Domains /Familiesfor SUZ12 gene

Functionfor SUZ12 gene

Pathways & Interactionsfor SUZ12 gene

Drugs & Compoundsfor SUZ12 gene

Transcriptsfor SUZ12 gene

Expression for SUZ12 gene

Orthologsfor SUZ12 gene

Paralogsfor SUZ12 gene

Genomic Variantsfor SUZ12 gene

Disorders / Diseasesfor SUZ12 gene

Publicationsfor SUZ12 gene

External Searches for SUZ12 gene

Genome Databases showing SUZ12 gene

Other Databases showing SUZ12 gene

Specialized Databases showing SUZ12 gene

Intellectual Propertyfor SUZ12 gene

Productsfor SUZ12 gene

View Random Gene

Aliases
for SUZ12 gene

Summaries
for SUZ12 gene

Genomic Views
for SUZ12 gene

Proteins
for SUZ12 gene

Protein Domains /
Families
for SUZ12 gene

Function
for SUZ12 gene

Pathways & Interactions
for SUZ12 gene

Drugs & Compounds
for SUZ12 gene

Transcripts
for SUZ12 gene

Expression
for SUZ12 gene

Orthologs
for SUZ12 gene

Paralogs
for SUZ12 gene

Genomic Variants
for SUZ12 gene

Disorders / Diseases
for SUZ12 gene

Publications
for SUZ12 gene

Intellectual Property
for SUZ12 gene

Products
for SUZ12 gene