Aliases for SUZ12 Gene
External Ids for SUZ12 Gene
Previous GeneCards Identifiers for SUZ12 Gene
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
GeneCards Summary for SUZ12 Gene
SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit) is a Protein Coding gene. Diseases associated with SUZ12 include Endometrial Stromal Sarcoma and Endometrial Stromal Nodule. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Cellular Senescence. GO annotations related to this gene include sequence-specific DNA binding and chromatin binding.
UniProtKB/Swiss-Prot for SUZ12 Gene
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates Lys-9 (H3K9me) and Lys-27 (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.