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Aliases for SUZ12 Gene

Aliases for SUZ12 Gene

  • SUZ12 Polycomb Repressive Complex 2 Subunit 2 3
  • Chromatin Precipitated E2F Target 9 Protein 3 4
  • Suppressor Of Zeste 12 Protein Homolog 3 4
  • Joined To JAZF1 Protein 3 4
  • ChET 9 Protein 3 4
  • CHET9 3 4
  • JJAZ1 3 4
  • Suppressor Of Zeste 12 Homolog (Drosophila) 2
  • Suppressor Of Zeste 12 Homolog 3
  • KIAA0160 4

External Ids for SUZ12 Gene

Previous GeneCards Identifiers for SUZ12 Gene

  • GC17P027289
  • GC17P030264

Summaries for SUZ12 Gene

Entrez Gene Summary for SUZ12 Gene

  • This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]

GeneCards Summary for SUZ12 Gene

SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit) is a Protein Coding gene. Diseases associated with SUZ12 include endometrial stromal sarcoma and endometrial stromal nodule. Among its related pathways are Cellular Senescence and Chromatin organization. GO annotations related to this gene include sequence-specific DNA binding and chromatin binding.

UniProtKB/Swiss-Prot for SUZ12 Gene

  • Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates Lys-9 (H3K9me) and Lys-27 (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

Gene Wiki entry for SUZ12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUZ12 Gene

Genomics for SUZ12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUZ12 Gene

Chromosome:
17
Start:
31,937,018 bp from pter
End:
32,001,045 bp from pter
Size:
64,028 bases
Orientation:
Plus strand

Genomic View for SUZ12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUZ12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUZ12 Gene

No data available for Regulatory Elements for SUZ12 Gene

Proteins for SUZ12 Gene

  • Protein details for SUZ12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15022-SUZ12_HUMAN
    Recommended name:
    Polycomb protein SUZ12
    Protein Accession:
    Q15022
    Secondary Accessions:
    • Q96BD9

    Protein attributes for SUZ12 Gene

    Size:
    739 amino acids
    Molecular mass:
    83055 Da
    Quaternary structure:
    • Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with WDR77. Interacts with histone H1. Interacts with CDYL. Interacts with ARNTL/BMAL1.
    Miscellaneous:
    • Under hypoxic conditions, the precursor SUZ12 RNA undergoes regulated trans-splicing with the JAZF1 RNA, resulting in a chimeric isoform which may be protective against apoptosis. The chimeric transcript is characterized by JAZF1 exons 1-3 joined to SUZ12 exon 2-16. The chimeric transcript is expressed primarily in the endometrium from late secretory and early proliferative phases of the menstrual cycle, but not in normal myometrium at any phase of the cycle. Its expression is slightly induced by low levels of progesterone, but suppressed by both estrogen and high levels of progesterone (PubMed:18772439).
    SequenceCaution:
    • Sequence=BAA09931.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SUZ12 Gene

Proteomics data for SUZ12 Gene at MOPED

Post-translational modifications for SUZ12 Gene

Other Protein References for SUZ12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SUZ12 (SUZ12)

No data available for DME Specific Peptides for SUZ12 Gene

Domains & Families for SUZ12 Gene

Gene Families for SUZ12 Gene

Protein Domains for SUZ12 Gene

Suggested Antigen Peptide Sequences for SUZ12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15022

UniProtKB/Swiss-Prot:

SUZ12_HUMAN :
  • Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
  • Contains 1 C2H2-type zinc finger.
Family:
  • Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with SUZ12: view

Function for SUZ12 Gene

Molecular function for SUZ12 Gene

UniProtKB/Swiss-Prot Function:
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates Lys-9 (H3K9me) and Lys-27 (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
UniProtKB/Swiss-Prot Induction:
Expression is induced by E2F1, E2F2 and E2F3.

Gene Ontology (GO) - Molecular Function for SUZ12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 17560333
GO:0035064 methylated histone binding IDA 21029866
genes like me logo Genes that share ontologies with SUZ12: view
genes like me logo Genes that share phenotypes with SUZ12: view

Animal Models for SUZ12 Gene

MGI Knock Outs for SUZ12:

Animal Model Products

miRNA for SUZ12 Gene

miRTarBase miRNAs that target SUZ12

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUZ12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SUZ12 Gene

Localization for SUZ12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUZ12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUZ12 Gene COMPARTMENTS Subcellular localization image for SUZ12 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SUZ12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001739 sex chromatin IEA --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0035098 ESC/E(Z) complex IMP 15385962
genes like me logo Genes that share ontologies with SUZ12: view

Pathways & Interactions for SUZ12 Gene

genes like me logo Genes that share pathways with SUZ12: view

Pathways by source for SUZ12 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat

Gene Ontology (GO) - Biological Process for SUZ12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SUZ12: view

No data available for SIGNOR curated interactions for SUZ12 Gene

Drugs & Compounds for SUZ12 Gene

(1) Drugs for SUZ12 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
genes like me logo Genes that share compounds with SUZ12: view

Transcripts for SUZ12 Gene

Unigene Clusters for SUZ12 Gene

Suppressor of zeste 12 homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUZ12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUZ12 Gene

No ASD Table

Relevant External Links for SUZ12 Gene

GeneLoc Exon Structure for
SUZ12
ECgene alternative splicing isoforms for
SUZ12

Expression for SUZ12 Gene

mRNA expression in normal human tissues for SUZ12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SUZ12 Gene

This gene is overexpressed in Adipocyte (16.2), Pancreatic juice (11.3), and Breast (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUZ12 Gene



SOURCE GeneReport for Unigene cluster for SUZ12 Gene Hs.462732

mRNA Expression by UniProt/SwissProt for SUZ12 Gene

Q15022-SUZ12_HUMAN
Tissue specificity: Overexpressed in breast and colon cancer.
genes like me logo Genes that share expression patterns with SUZ12: view

Protein tissue co-expression partners for SUZ12 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SUZ12 Gene

Orthologs for SUZ12 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUZ12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUZ12 35
  • 95.9 (n)
  • 99.19 (a)
SUZ12 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUZ12 35
  • 96.48 (n)
  • 99.05 (a)
SUZ12 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Suz12 35
  • 92.91 (n)
  • 97.62 (a)
Suz12 16
Suz12 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUZ12 35
  • 99.82 (n)
  • 99.46 (a)
SUZ12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC688041 35
  • 92.15 (n)
  • 94.73 (a)
oppossum
(Monodelphis domestica)
Mammalia SUZ12 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUZ12 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUZ12 35
  • 86.22 (n)
  • 94.78 (a)
SUZ12 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUZ12 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1012 35
suz12 35
  • 77.5 (n)
  • 87.03 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8479 35
zebrafish
(Danio rerio)
Actinopterygii suz12b 35
  • 71.79 (n)
  • 78.96 (a)
suz12a 36
  • 73 (a)
OneToMany
suz12b 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Su(z)12 35
  • 49.53 (n)
  • 45.1 (a)
Su(z)12 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for SUZ12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUZ12 Gene

ENSEMBL:
Gene Tree for SUZ12 (if available)
TreeFam:
Gene Tree for SUZ12 (if available)

Paralogs for SUZ12 Gene

Pseudogenes.org Pseudogenes for SUZ12 Gene

genes like me logo Genes that share paralogs with SUZ12: view

No data available for Paralogs for SUZ12 Gene

Variants for SUZ12 Gene

Sequence variations from dbSNP and Humsavar for SUZ12 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs10627 -- 32,000,300(+) ATTTT(A/G)TTTAA utr-variant-3-prime
rs55882925 -- 31,980,038(+) AGAGA(-/GA)AACAG intron-variant
rs55864871 -- 31,997,687(+) AAAAA(-/AAA)GGCCA intron-variant
rs55832508 -- 31,995,639(+) ACATA(C/T)AGTAG synonymous-codon, reference
rs55811201 -- 31,993,852(+) TTTTT(-/A/T)AATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUZ12 Gene

Variant ID Type Subtype PubMed ID
dgv944e1 CNV Complex 17122850
nsv908065 CNV Loss 21882294
nsv2025 CNV Loss 18451855
nsv908066 CNV Gain 21882294
nsv908067 CNV Gain 21882294
esv2678272 CNV Deletion 23128226
esv2665285 CNV Deletion 23128226

Variation tolerance for SUZ12 Gene

Residual Variation Intolerance Score: 18.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUZ12 Gene

HapMap Linkage Disequilibrium report
SUZ12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUZ12 Gene

Disorders for SUZ12 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SUZ12 Gene - From: Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
endometrial stromal nodule
endometrial stromal tumor
  • endometrial stromal neoplasm
- elite association
Search SUZ12 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SUZ12_HUMAN
  • Note=A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. {ECO:0000269 PubMed:11371647}.

Relevant External Links for SUZ12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUZ12
genes like me logo Genes that share disorders with SUZ12: view

No data available for Genatlas for SUZ12 Gene

Publications for SUZ12 Gene

  1. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. (PMID: 11371647) Koontz J.I. … Sklar J. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 23 67
  2. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2. (PMID: 19293275) Kim H. … Kim J. (Nucleic Acids Res. 2009) 23 67
  3. Regulation of CD11b transcription by decreasing PRC2 and increased acH4 level during ATRA-induced HL-60 differentiation. (PMID: 19578722) Tang H. … Zhang F. (Acta Biochim. Biophys. Sin. (Shanghai) 2009) 23 67
  4. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. (PMID: 19638619) Fiskus W. … Bhalla K.N. (Blood 2009) 23 67
  5. Expression, imprinting, and evolution of rice homologs of the polycomb group genes. (PMID: 19825651) Luo M. … Dennis E.S. (Mol Plant 2009) 23 67

Products for SUZ12 Gene

Sources for SUZ12 Gene

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