Aliases for SUZ12 Gene
External Ids for SUZ12 Gene
Previous GeneCards Identifiers for SUZ12 Gene
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
GeneCards Summary for SUZ12 Gene
SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit) is a Protein Coding gene. Diseases associated with SUZ12 include endometrial stromal sarcoma and endometrial stromal nodule. Among its related pathways are Chromatin Regulation / Acetylation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and chromatin binding.
UniProtKB/Swiss-Prot for SUZ12 Gene
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates Lys-9 (H3K9me) and Lys-27 (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.