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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUV420H2 Gene

protein-coding   GIFtS: 55
GCID: GC19P055851

Suppressor Of Variegation 4-20 Homolog 2 (Drosophila)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppressor Of Variegation 4-20 Homolog 2 (Drosophila)1 2     suv4-20h22
Lysine N-Methyltransferase 5C2 3     EC 2.1.1.433
Su(Var)4-20 Homolog 22 3     Suv4-20h23
KMT5C2 3     Suppressor Of Variegation 4-20 Homolog 23
Histone-Lysine N-Methyltransferase SUV420H22     

External Ids:    HGNC: 284051   Entrez Gene: 847872   Ensembl: ENSG000001332477   OMIM: 6131985   UniProtKB: Q86Y973   

Export aliases for SUV420H2 gene to outside databases

Previous GC identifers: GC19P060544 GC19P052174


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUV420H2 Gene:
SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically
trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 (PubMed
15145825)).(supplied by OMIM, Dec 2009)

GeneCards Summary for SUV420H2 Gene: 
SUV420H2 (suppressor of variegation 4-20 homolog 2 (Drosophila)) is a protein-coding gene. Diseases associated with SUV420H2 include breast cancer. GO annotations related to this gene include protein binding and histone methyltransferase activity (H4-K20 specific). An important paralog of this gene is SUV420H1.

UniProtKB/Swiss-Prot: SV422_HUMAN, Q86Y97
Function: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20'
trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in
pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive
heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins
(RB1, RBL1 and RBL2) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUV420H2 gene promoter:
         ER-alpha   RFX1   NF-YA   C/EBPalpha   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUV420H2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SUV420H2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUV420H2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

SUV420H2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUV420H2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055851:  view genomic region     (about GC identifiers)

Start:
55,851,221 bp from pter      End:
55,859,489 bp from pter
Size:
8,269 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SV422_HUMAN, Q86Y97 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SUV420H2  
Size: 462 amino acids; 52113 Da
Subunit: Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2
(By similarity)
Subcellular location: Nucleus. Chromosome (By similarity). Note=Associated with pericentric heterochromatin. CBX1
and CBX5 are required for the localization to pericentric heterochromatin (By similarity)
Sequence caution: Sequence=AAH05842.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=AAL55766.1;
Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
1 PDB 3D structure from and Proteopedia for SUV420H2:
3RQ4 (3D)    
Secondary accessions: Q8WZ10 Q9BRZ6
Alternative splicing: 2 isoforms:  Q86Y97-1   Q86Y97-2   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SUV420H2: NX_Q86Y97

Explore proteomics data for SUV420H2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86Y97

  • SUV420H2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SUV420H2 Protein Expression
    REFSEQ proteins: NP_116090.2  
    ENSEMBL proteins: 
     ENSP00000255613   ENSP00000397296   ENSP00000467499  

    Human Recombinant Protein Products for SUV420H2: 
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    Sino Biological Recombinant Protein for SUV420H2
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUV420H2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000780condensed nuclear chromosome, centromeric region IEA--

    SUV420H2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KMT: Chromatin-modifying enzymes / K-methyltransferases

    2 InterPro protein domains:
     IPR025790 Hist-Lys_N-MTase_Suvar4-20
     IPR001214 SET_dom

    Graphical View of Domain Structure for InterPro Entry Q86Y97

    ProtoNet protein and cluster: Q86Y97

    UniProtKB/Swiss-Prot: SV422_HUMAN, Q86Y97
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. Suvar4-20 subfamily
    Similarity: Contains 1 SET domain


    SUV420H2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SV422_HUMAN, Q86Y97
    Function: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20'
    trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in
    pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive
    heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins
    (RB1, RBL1 and RBL2) (By similarity)
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Number (IUBMB): EC 2.1.1.431

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19486527
    GO:0042799histone methyltransferase activity (H4-K20 specific) IEA--
         
    SUV420H2 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Suv420h2):
     cellular  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  no phenotypic analysis  normal  respiratory system 

    SUV420H2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Suv420h2tm1.1Jnw for SUV420H2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SUV420H2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUV420H2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUV420H2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUV420H2 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSUV420H2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV420H2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SUV420H2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Lysine degradation
    Lysine degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for SUV420H2):
        Lysine degradation


    SUV420H2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SUV420H2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/29 Interacting proteins for SUV420H2 (Q86Y972, 3 ENSP000002556134) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0016571histone methylation ----
    GO:0034770histone H4-K20 methylation ----
    GO:0034773histone H4-K20 trimethylation IEA--

    SUV420H2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUV420H2 (SV422)

    2 HMDB Compounds for SUV420H2    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    Search CenterWatch for drugs/clinical trials and news about SUV420H2 / SV422

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUV420H2 gene: 
    NM_032701.3  

    Unigene Cluster for SUV420H2:

    Suppressor of variegation 4-20 homolog 2 (Drosophila)
    Hs.590982  [show with all ESTs]
    Unigene Representative Sequence: NM_032701
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589338 ENST00000255613(uc002qkj.4) ENST00000498738 ENST00000402499
    ENST00000445196(uc002qkl.3) ENST00000464185(uc010esx.1 uc002qkk.1)
    ENST00000592631 ENST00000468951 ENST00000460956 ENST00000587442 ENST00000474492

    miRNA
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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate SUV420H2 (see all 36):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-29a hsa-miR-624 hsa-miR-372 hsa-miR-302b hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidSUV420H2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF289582.1 AK304562.1 AK308586.1 BC005842.2 BC019313.2 BC044889.1 

    11 DOTS entries:

    DT.91723142  DT.95199260  DT.441625  DT.121644888  DT.100688683  DT.75126136  DT.100718174  DT.100814927 
    DT.40309198  DT.91942496  DT.99953821 

    24/49 AceView cDNA sequences (see all 49):

    BC019313 CR612424 AI273968 AL539958 BX280041 AW250245 BC044889 AI792295 
    NM_032701 BC005842 AI884316 AW248704 CF994542 BG723304 BG396404 BM804731 
    AW249135 AI567488 BE294123 AF289582 BE548847 BG394193 BM021148 R61693 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SUV420H2 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                    -     -     -     -     -                             -                     
    SP2:                    -     -     -     -     -                                                   
    SP3:                    -                                                                           
    SP4:                    -     -     -                                                               
    SP5:                                            -                                                   


    ECgene alternative splicing isoforms for SUV420H2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUV420H2 expression in normal human tissues (normalized intensities)      SUV420H2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTATCCT
    SUV420H2 Expression
    About this image


    SUV420H2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
             brain/midbrain   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Eye (Sensory Organs)
             Retina

    See SUV420H2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUV420H2

    SOURCE GeneReport for Unigene cluster: Hs.590982
        SABiosciences Custom PCR Arrays for SUV420H2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV420H2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SUV420H2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Suv420h21 , 5 suppressor of variegation 4-20 homolog 2 (Drosophila)1, 5 82.54(n)1
    82.17(a)1
      7 (2.74 cM)5
    2328111  NM_001115018.11  NP_001108490.11 
     47401155 
    lizard
    (Anolis carolinensis)
    Reptilia SUV420H26
    Uncharacterized protein
    39(a)
    1 ↔ 1
    GL343329.1(1248755-1262413)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.45082 Transcribed sequence with weak similarity to protein more 73.69(n)    CF237967.1 
    zebrafish
    (Danio rerio)
    Actinopterygii suv420h26
    suppressor of variegation 4-20 homolog 2 (Drosophi...
    8(a)
    1 ↔ 1
    3(31018139-31039534)
    fruit fly
    (Drosophila melanogaster)
    Insecta Hmt4-206
    Histone methyltransferase 4-20
    12(a)
    1 → many
    X(542516-550075)
    worm
    (Caenorhabditis elegans)
    Secernentea set-46
    Histone-lysine N-methyltransferase Suv4-20
    39(a)
    1 → many
    II(6329850-6331318)


    ENSEMBL Gene Tree for SUV420H2 (if available)
    TreeFam Gene Tree for SUV420H2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUV420H2 gene
    SUV420H12  
    1 SIMAP similar gene for SUV420H2 using alignment to 1 protein entry:     SV422_HUMAN:
    SUV420H1

    SUV420H2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/298 SNPs in SUV420H2 are shown (see all 298)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1861616581,2
    --52171522(+) TTGAAC/TGAGCC 1 -- us2k10--------
    rs1909356561,2
    --52171523(+) TGAATA/GAGCCC 1 -- us2k10--------
    rs1833903711,2
    --55849232(+) GAGACC/GCTGTC 1 -- us2k10--------
    rs285251811,2
    C,F--55849239(+) TGTCTC/GTACAA 1 -- us2k15Minor allele frequency- G:0.10WA NA CSA 243
    rs790124401,2
    C--55849316(+) TGTAGG/AATCGC 1 -- us2k12Minor allele frequency- A:0.29NA 122
    rs1490960211,2
    --55849392(+) AGAGGA/CAGACC 1 -- us2k10--------
    rs1421643831,2
    --55849516(+) CCAACA/GTGGTG 1 -- us2k10--------
    rs790408201,2
    F--55849517(+) CAACAC/TGGTGA 1 -- us2k11Minor allele frequency- T:0.50NA 4
    rs711817561,2
    C--55849560(-) GCTAA-/T/TT  
            
    TTTTT
    1 -- us2k11NA 2
    rs287420771,2
    C--55849566(+) TTAGCC/TGGGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SUV420H2 (55851221 - 55859489 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SUV420H2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv26533CNV Loss19812545
    dgv4017n71CNV Loss21882294
    nsv912461CNV Loss21882294
    nsv516199CNV Loss19592680
    nsv912463CNV Loss21882294
    nsv912457CNV Loss21882294
    dgv4016n71CNV Loss21882294
    nsv912460CNV Loss21882294
    nsv470162CNV Loss18288195

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613198    OMIM disorders: --

    2 diseases for SUV420H2:    About MalaCards
    breast cancer    


    SUV420H2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SUV420H2

    Export disorders for SUV420H2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUV420H2 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SUV420H2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Loci at chromosomes 13, 19 and 20 influence age at na tural menopause. (PubMed id 19448619)1, 4 Stolk L....Uitterlinden A.G. (2009)
    2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. SUV420H2-mediated H4K20 trimethylation enforces RNA p olymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetyla tion. (PubMed id 21321083)1 Kapoor-Vazirani P....Vertino P.M. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    9. Comparative analyses of SUV420H1 isoforms and SUV420H 2 reveal differences in their cellular localization and effects on myogenic dif ferentiation. (PubMed id 21206904)1 Tsang L.W....Underhill D.A. (2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84787 HGNC: 28405 AceView: SUV420H2 Ensembl:ENSG00000133247 euGenes: HUgn84787
    ECgene: SUV420H2 Kegg: 84787 H-InvDB: SUV420H2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUV420H2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUV420H2 gene:
    Search GeneIP for patents involving SUV420H2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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