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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SUV420H2 Gene

protein-coding GIFtS: 52
GCID: GC19P055851

suppressor of variegation 4-20 homolog 2 (Drosophila)

Explore 2 diseases affiliated with
SUV420H2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Suppressor Of Variegation 4-20 Homolog 2 (Drosophila)¹ ²		Histone-Lysine N-Methyltransferase SUV420H2²
KMT5C¹ ² ³		Suv4-20h2³
Lysine N-Methyltransferase 5C² ³		EC 2.1.1.43³
Su(Var)4-20 Homolog 2² ³		Suv4-20h2³
MGC2705¹		Suppressor Of Variegation 4-20 Homolog 2³

External Ids:	HGNC: 28405¹	Entrez Gene: 84787²	Ensembl: ENSG00000133247⁷	OMIM: 613198⁵	UniProtKB: Q86Y97³

Export aliases for SUV420H2 gene to outside databases

Previous GC identifers: GC19P060544 GC19P052174

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUV420H2:

SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically

trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 (PubMed

15145825)).(supplied by OMIM, Dec 2009)

UniProtKB/Swiss-Prot: SV422_HUMAN, Q86Y97

Function: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation

represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin

regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions.

SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SUV420H2 gene promoter:
ER-alpha RFX1 NF-YA C/EBPalpha CBF-A CBF-B CP1A CP1C NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SUV420H2 promoter sequence

Search SABiosciences Chromatin IP Primers for SUV420H2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUV420H2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42

SUV420H2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUV420H2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P055851: view genomic region (about GC identifiers)

Start:	55,851,221 bp from pter	End:	55,859,489 bp from pter
Size:	8,269 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SV422_HUMAN, Q86Y97 (See protein sequence)

Recommended Name: Histone-lysine N-methyltransferase SUV420H2

Size: 462 amino acids; 52113 Da

Subunit: Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By

similarity)

Subcellular location: Nucleus. Chromosome (By similarity). Note=Associated with pericentric heterochromatin. CBX1 and

CBX5 are required for the localization to pericentric heterochromatin (By similarity)

Sequence caution: Sequence=AAH05842.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=AAL55766.1;

Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

1 PDB 3D structure from and Proteopedia for SUV420H2:

3RQ4 (3D)

Secondary accessions: Q8WZ10 Q9BRZ6

Alternative splicing: 2 isoforms: Q86Y97-1 Q86Y97-2 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SUV420H2: NX_Q86Y97

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86Y97

SUV420H2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_116090.2

ENSEMBL proteins:

ENSP00000466635 ENSP00000255613 ENSP00000397296 ENSP00000466384 ENSP00000467499

Human Recombinant Protein Products for SUV420H2:

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	Uscn Proteins for SUV420H2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000780	condensed nuclear chromosome, centromeric region	IEA	--

SUV420H2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SUV420H2 for domains About GeneDecksing

2 InterPro domains/families:

IPR025790 Hist-Lys_N-MTase_Suvar4-20

IPR001214 SET_dom

Graphical View of Domain Structure for InterPro Entry Q86Y97

ProtoNet protein and cluster: Q86Y97

UniProtKB/Swiss-Prot: SV422_HUMAN, Q86Y97

Similarity: Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily

Similarity: Contains 1 SET domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SV422_HUMAN, Q86Y97

Function: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation

represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin

regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions.

SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity)

Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +

N(6)-methyl-L-lysine-[histone]

Enzyme Number (IUBMB): EC 2.1.1.43¹

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19486527
GO:0042799	histone methyltransferase activity (H4-K20 specific)	IEA	--

SUV420H2 for ontologies About GeneDecksing

Phenotypes:
9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Suv420h2):

cellular	growth/size	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	no phenotypic analysis	normal	respiratory system

SUV420H2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Suv420h2^tm1.1Jnw for SUV420H2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SUV420H2

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUV420H2
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate SUV420H2 (see all 36):
		hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-29a hsa-miR-624 hsa-miR-372 hsa-miR-302b hsa-miR-520b

		SwitchGear 3'UTR luciferase reporter plasmid: SUV420H2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUV420H2 (see all 7) OriGene shRNA RFP: SUV420H2 OriGene siRNA: SUV420H2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV420H2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Lysine degradation

Lysine degradation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for SUV420H2):

Lysine degradation

SUV420H2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SUV420H2

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/29 Interacting proteins for SUV420H2 (Q86Y97^{2, 3} ENSP00000255613⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=1 STRING: ENSP00000352980
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0016571	histone methylation	--	--
GO:0034770	histone H4-K20 methylation	--	--
GO:0034773	histone H4-K20 trimethylation	IEA	--

SUV420H2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SUV420H2

2 HMDB Compounds for SUV420H2 About this table

Compound	Synonyms	CAS #	PubMed Ids
S-Adenosylhomocysteine	(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)	979-92-0	--
S-Adenosylmethionine	(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)	29908-03-0	--

Search CenterWatch for drugs/clinical trials and news about SUV420H2 / SV422

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SUV420H2 gene:

NM_032701.3

Unigene Cluster for SUV420H2:

Suppressor of variegation 4-20 homolog 2 (Drosophila)

Hs.590982 [show with all ESTs]

Unigene Representative Sequence: NM_032701

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000589338 ENST00000255613(uc002qkj.4) ENST00000498738 ENST00000402499

ENST00000445196(uc002qkl.3) ENST00000464185(uc010esx.1 uc002qkk.1)

ENST00000592631 ENST00000468951 ENST00000460956 ENST00000587442 ENST00000474492

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		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate SUV420H2 (see all 36):
		hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-29a hsa-miR-624 hsa-miR-372 hsa-miR-302b hsa-miR-520b

		SwitchGear 3'UTR luciferase reporter plasmid: SUV420H2 3' UTR sequence

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Additional cDNA sequence:

AF289582.1 AK304562.1 AK308586.1 BC005842.2 BC019313.2 BC044889.1

11 DOTS entries:

DT.91723142 DT.95199260 DT.441625 DT.121644888 DT.100688683 DT.75126136 DT.100718174 DT.100814927

DT.40309198 DT.91942496 DT.99953821

24/49 AceView cDNA sequences (see all 49):

BC019313 BC005842 AI792295 CR612424 AL539958 BC044889 AI273968 AW250245

BX280041 NM_032701 AW248704 BG723304 AW249135 BM021148 BG396404 BM804731

AI567488 CF994542 BE294123 AI884316 BE548847 AF289582 BG394193 BG722579

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SUV420H2 (see all 7) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9
SP1:							-		-		-		-		-										-
SP2:							-		-		-		-		-
SP3:							-
SP4:							-		-		-
SP5:															-

ECgene alternative splicing isoforms for SUV420H2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SUV420H2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCTATCCT

About this image
See SUV420H2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SUV420H2

SOURCE GeneReport for Unigene cluster: Hs.590982
SABiosciences Custom PCR Arrays for SUV420H2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUV420H2 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SUV420H2 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Suv420h2^{1 , 5}	suppressor of variegation 4-20 homolog 2 (Drosophila)^{1, 5}	82.54(n)¹ 82.17(a)¹		7 (2.74 cM)⁵ 232811¹ NM_001115018.1¹ NP_001108490.1¹ 4740115⁵
lizard (Anolis carolinensis)	Reptilia	SUV420H2⁶	--	48(a)	1 ↔ 1	GL343329.1(1248755-1256377)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.4508²	Transcribed sequence with weak similarity to protein more	73.69(n)		CF237967.1
zebrafish (Danio rerio)	Actinopterygii	suv420h2⁶	suppressor of variegation 4-20 homolog 2 (Drosophi...	9(a)	1 ↔ 1	3(31018139-31039534)
fruit fly (Drosophila melanogaster)	Insecta	Hmt4-20⁶	Histone methyltransferase 4-20	12(a)	1 → many	X(542516-550075)
worm (Caenorhabditis elegans)	Secernentea	set-4⁶	Histone-lysine N-methyltransferase Suv4-20	38(a)	1 → many	II(6329818-6331286)

ENSEMBL Gene Tree for SUV420H2 (if available)
TreeFam Gene Tree for SUV420H2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SUV420H2 gene

SUV420H1²

1 SIMAP similar gene for SUV420H2 using alignment to 1 protein entry: SV422_HUMAN:

SUV420H1

SUV420H2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183390371^1,2		--	55849232(+)	`GAGACC/GCTGTC`	1	--	us2k¹		0	--	--	--	--
rs28525181^1,2	C,F	--	55849239(+)	`TGTCTC/GTACAA`	1	--	us2k¹		5		WA NA CSA	243
rs79012440^1,2	C	--	55849316(+)	`TGTAGG/AATCGC`	1	--	us2k¹		2		NA	122
rs149096021^1,2		--	55849392(+)	`AGAGGA/CAGACC`	1	--	us2k¹		0	--	--	--	--
rs142164383^1,2		--	55849516(+)	`CCAACA/GTGGTG`	1	--	us2k¹		0	--	--	--	--
rs79040820^1,2	F	--	55849517(+)	`CAACAC/TGGTGA`	1	--	us2k¹		1		NA	4
rs28742077^1,2		--	55849566(+)	`TTAGCC/TGGGCA`	1	--	us2k¹		0	--	--	--	--
rs140388549^1,2		--	55849623(+)	`GAAAAC/TCGCTT`	1	--	us2k¹		0	--	--	--	--
rs111284973^1,2	C	--	55849661(+)	`GCCGAG/CATCGC`	1	--	us2k¹		2		WA CSA	3
rs78312581^1,2	C	--	55849708(+)	`TGTCT-/AAAAAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SUV420H2 (55851221 - 55859489 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SUV420H2
1 CNV: 30085
1 Indel: 67617

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SUV420H2 for disorders           About GeneDecksing

OMIM gene information: 613198    OMIM disorders: --

2 diseases for SUV420H2:    About MalaCards

homocysteine breast cancer

Export disorders for SUV420H2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SUV420H2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with SUV420H2)

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Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{1, 2} Wan D....Gu J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
SUV420H2-mediated H4K20 trimethylation enforces RNA p olymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetyla tion. (PubMed id 21321083)¹ Kapoor-Vazirani P....Vertino P.M. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Comparative analyses of SUV420H1 isoforms and SUV420H 2 reveal differences in their cellular localization and effects on myogenic dif ferentiation. (PubMed id 21206904)¹ Tsang L.W....Underhill D.A. (2010)
Loci at chromosomes 13, 19 and 20 influence age at na tural menopause. (PubMed id 19448619)¹ Stolk L....Uitterlinden A.G. (2009)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
The histone methyltransferase SUV420H2 and Heterochro matin Proteins HP1 interact but show different dynamic behaviours. (PubMed id 19486527)¹ Souza P.P....Angrand P.O. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84787	HGNC: 28405	AceView: SUV420H2	Ensembl:ENSG00000133247	euGenes: HUgn84787
ECgene: SUV420H2	Kegg: 84787	H-InvDB: SUV420H2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SUV420H2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SUV420H2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SUV420H2 gene:
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SUV420H2 Gene

suppressor of variegation 4-20 homolog 2 (Drosophila)

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suppressor of variegation 4-20 homolog 2 (Drosophila)

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