Aliases for SUV420H2 Gene
External Ids for SUV420H2 Gene
Previous GeneCards Identifiers for SUV420H2 Gene
SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]
GeneCards Summary for SUV420H2 Gene
SUV420H2 (Suppressor Of Variegation 4-20 Homolog 2 (Drosophila)) is a Protein Coding gene. Among its related pathways are Lysine degradation. GO annotations related to this gene include histone methyltransferase activity (H4-K20 specific). An important paralog of this gene is SUV420H1.
UniProtKB/Swiss-Prot for SUV420H2 Gene
Histone methyltransferase that specifically trimethylates Lys-20 of histone H4. H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).