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Aliases for SUV420H2 Gene

Aliases for SUV420H2 Gene

  • Suppressor Of Variegation 4-20 Homolog 2 (Drosophila) 2 3
  • Lysine N-Methyltransferase 5C 3 4
  • Su(Var)4-20 Homolog 2 3 4
  • Suv4-20h2 3 4
  • KMT5C 3 4
  • Suppressor Of Variegation 4-20 Homolog 2 4
  • EC 2.1.1.43 4

External Ids for SUV420H2 Gene

Previous GeneCards Identifiers for SUV420H2 Gene

  • GC19P060544
  • GC19P055851
  • GC19P052174

Summaries for SUV420H2 Gene

Entrez Gene Summary for SUV420H2 Gene

  • SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]

GeneCards Summary for SUV420H2 Gene

SUV420H2 (Suppressor Of Variegation 4-20 Homolog 2 (Drosophila)) is a Protein Coding gene. Among its related pathways are Lysine degradation. GO annotations related to this gene include histone methyltransferase activity (H4-K20 specific). An important paralog of this gene is SUV420H1.

UniProtKB/Swiss-Prot for SUV420H2 Gene

  • Histone methyltransferase that specifically trimethylates Lys-20 of histone H4. H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUV420H2 Gene

Genomics for SUV420H2 Gene

Regulatory Elements for SUV420H2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUV420H2 Gene

Chromosome:
19
Start:
55,339,210 bp from pter
End:
55,348,121 bp from pter
Size:
8,912 bases
Orientation:
Plus strand

Genomic View for SUV420H2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUV420H2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUV420H2 Gene

Proteins for SUV420H2 Gene

  • Protein details for SUV420H2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y97-SV422_HUMAN
    Recommended name:
    Histone-lysine N-methyltransferase SUV420H2
    Protein Accession:
    Q86Y97
    Secondary Accessions:
    • Q8WZ10
    • Q9BRZ6

    Protein attributes for SUV420H2 Gene

    Size:
    462 amino acids
    Molecular mass:
    52113 Da
    Quaternary structure:
    • Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity).
    SequenceCaution:
    • Sequence=AAH05842.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAL55766.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUV420H2 Gene

    Alternative splice isoforms for SUV420H2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUV420H2 Gene

Proteomics data for SUV420H2 Gene at MOPED

Post-translational modifications for SUV420H2 Gene

  • Ubiquitination at Lys 122
  • Modification sites at PhosphoSitePlus

Other Protein References for SUV420H2 Gene

Antibody Products

No data available for DME Specific Peptides for SUV420H2 Gene

Domains & Families for SUV420H2 Gene

Protein Domains for SUV420H2 Gene

Suggested Antigen Peptide Sequences for SUV420H2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y97

UniProtKB/Swiss-Prot:

SV422_HUMAN :
  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
Domain:
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
genes like me logo Genes that share domains with SUV420H2: view

No data available for Gene Families for SUV420H2 Gene

Function for SUV420H2 Gene

Molecular function for SUV420H2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
UniProtKB/Swiss-Prot Function:
Histone methyltransferase that specifically trimethylates Lys-20 of histone H4. H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).

Enzyme Numbers (IUBMB) for SUV420H2 Gene

Gene Ontology (GO) - Molecular Function for SUV420H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19486527
GO:0042799 histone methyltransferase activity (H4-K20 specific) IEA --
genes like me logo Genes that share ontologies with SUV420H2: view
genes like me logo Genes that share phenotypes with SUV420H2: view

Animal Models for SUV420H2 Gene

MGI Knock Outs for SUV420H2:

Animal Model Products

CRISPR Products

miRNA for SUV420H2 Gene

miRTarBase miRNAs that target SUV420H2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUV420H2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for SUV420H2 Gene

Localization for SUV420H2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUV420H2 Gene

Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUV420H2 Gene COMPARTMENTS Subcellular localization image for SUV420H2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for SUV420H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000780 condensed nuclear chromosome, centromeric region IEA --
GO:0005654 nucleoplasm IDA --
GO:0005720 nuclear heterochromatin IDA 19486527
GO:0005721 pericentric heterochromatin IDA 19486527
genes like me logo Genes that share ontologies with SUV420H2: view

Pathways & Interactions for SUV420H2 Gene

SuperPathways for SUV420H2 Gene

Superpath Contained pathways
1 Lysine degradation
genes like me logo Genes that share pathways with SUV420H2: view

Pathways by source for SUV420H2 Gene

1 KEGG pathway for SUV420H2 Gene

Gene Ontology (GO) - Biological Process for SUV420H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016571 histone methylation --
GO:0034773 histone H4-K20 trimethylation IEA --
genes like me logo Genes that share ontologies with SUV420H2: view

No data available for SIGNOR curated interactions for SUV420H2 Gene

Drugs & Compounds for SUV420H2 Gene

(2) Drugs for SUV420H2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with SUV420H2: view

Transcripts for SUV420H2 Gene

Unigene Clusters for SUV420H2 Gene

Suppressor of variegation 4-20 homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUV420H2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUV420H2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: -
SP6:
SP7:

Relevant External Links for SUV420H2 Gene

GeneLoc Exon Structure for
SUV420H2
ECgene alternative splicing isoforms for
SUV420H2

Expression for SUV420H2 Gene

mRNA expression in normal human tissues for SUV420H2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SUV420H2 Gene

This gene is overexpressed in Platelet (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUV420H2 Gene



SOURCE GeneReport for Unigene cluster for SUV420H2 Gene Hs.590982

genes like me logo Genes that share expression patterns with SUV420H2: view

Protein tissue co-expression partners for SUV420H2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SUV420H2 Gene

Orthologs for SUV420H2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUV420H2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUV420H2 35
  • 86.4 (n)
  • 88.03 (a)
SUV420H2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUV420H2 35
  • 86.2 (n)
  • 88.02 (a)
SUV420H2 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Suv420h2 35
  • 82.03 (n)
  • 81.74 (a)
Suv420h2 16
Suv420h2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUV420H2 35
  • 98.92 (n)
  • 98.27 (a)
SUV420H2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Suv420h2 35
  • 81.81 (n)
  • 82.83 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SUV420H2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUV420H2 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4508 35
zebrafish
(Danio rerio)
Actinopterygii suv420h2 36
  • 8 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hmt4-20 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea set-4 36
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9369 36
  • 52 (a)
OneToMany
Species with no ortholog for SUV420H2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUV420H2 Gene

ENSEMBL:
Gene Tree for SUV420H2 (if available)
TreeFam:
Gene Tree for SUV420H2 (if available)

Paralogs for SUV420H2 Gene

Paralogs for SUV420H2 Gene

(1) SIMAP similar genes for SUV420H2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SUV420H2: view

Variants for SUV420H2 Gene

Sequence variations from dbSNP and Humsavar for SUV420H2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs544763399 -- 55,344,100(+) CCGGG(C/T)GCGGT intron-variant
rs546071632 -- 55,341,716(+) CCCTA(C/T)TCTCA intron-variant, upstream-variant-2KB
rs544626111 -- 55,339,376(+) GAAGC(C/T)TTCCT upstream-variant-2KB, utr-variant-5-prime
rs544557862 -- 55,339,358(+) TTTCT(C/G)CCTCC upstream-variant-2KB, utr-variant-5-prime
rs544552346 -- 55,339,683(+) GTTTG(A/T)CGGCG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SUV420H2 Gene

Variant ID Type Subtype PubMed ID
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
nsv912460 CNV Loss 21882294
nsv912461 CNV Loss 21882294
nsv470162 CNV Loss 18288195
dgv4017n71 CNV Loss 21882294
nsv912463 CNV Loss 21882294
esv26533 CNV Loss 19812545
nsv516199 CNV Loss 19592680

Variation tolerance for SUV420H2 Gene

Residual Variation Intolerance Score: 36.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUV420H2 Gene

HapMap Linkage Disequilibrium report
SUV420H2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUV420H2 Gene

Disorders for SUV420H2 Gene

Relevant External Links for SUV420H2

Genetic Association Database (GAD)
SUV420H2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUV420H2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUV420H2
genes like me logo Genes that share disorders with SUV420H2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUV420H2 Gene

Publications for SUV420H2 Gene

  1. The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours. (PMID: 19486527) Souza P.P. … Angrand P.O. (BMC Cell Biol. 2009) 2 67
  2. SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3. (PMID: 25814362) Shinchi Y. … Matsuura N. (Exp. Cell Res. 2015) 67
  3. Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2. (PMID: 24396869) Wu H. … Min J. (FEBS Lett. 2013) 67
  4. SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation. (PMID: 21321083) Kapoor-Vazirani P. … Vertino P.M. (Mol. Cell. Biol. 2011) 67
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 67

Products for SUV420H2 Gene

Sources for SUV420H2 Gene

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