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Aliases for SUV420H1 Gene

Aliases for SUV420H1 Gene

  • Suppressor Of Variegation 4-20 Homolog 1 (Drosophila) 2 3
  • Lysine N-Methyltransferase 5B 3 4
  • Su(Var)4-20 Homolog 1 3 4
  • Suv4-20h1 3 4
  • CGI85 3 6
  • KMT5B 3 4
  • Histone-Lysine N-Methyltransferase SUV420H1 3
  • Suppressor Of Variegation 4-20 Homolog 1 4
  • C630029K18Rik 3
  • EC 2.1.1.43 4
  • CGI-85 3

External Ids for SUV420H1 Gene

Previous GeneCards Identifiers for SUV420H1 Gene

  • GC11M067680
  • GC11M067922
  • GC11M064258

Summaries for SUV420H1 Gene

Entrez Gene Summary for SUV420H1 Gene

  • This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for SUV420H1 Gene

SUV420H1 (Suppressor Of Variegation 4-20 Homolog 1 (Drosophila)) is a Protein Coding gene. Among its related pathways are Glucocorticoid receptor regulatory network and Lysine degradation. GO annotations related to this gene include histone-lysine N-methyltransferase activity and histone methyltransferase activity (H4-K20 specific). An important paralog of this gene is SUV420H2.

UniProtKB/Swiss-Prot for SUV420H1 Gene

  • Histone methyltransferase that specifically trimethylates Lys-20 of histone H4. H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.

Gene Wiki entry for SUV420H1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUV420H1 Gene

Genomics for SUV420H1 Gene

Regulatory Elements for SUV420H1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUV420H1 Gene

Start:
68,154,863 bp from pter
End:
68,213,828 bp from pter
Size:
58,966 bases
Orientation:
Minus strand

Genomic View for SUV420H1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUV420H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUV420H1 Gene

Proteins for SUV420H1 Gene

  • Protein details for SUV420H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4FZB7-SV421_HUMAN
    Recommended name:
    Histone-lysine N-methyltransferase SUV420H1
    Protein Accession:
    Q4FZB7
    Secondary Accessions:
    • B7WNX7
    • Q3SX56
    • Q4V775
    • Q6P150
    • Q96E44
    • Q9BUL0
    • Q9H022
    • Q9H2K3
    • Q9NXV3
    • Q9Y393

    Protein attributes for SUV420H1 Gene

    Size:
    885 amino acids
    Molecular mass:
    99187 Da
    Quaternary structure:
    • Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity). Interacts (via C-terminus) with FRG1.
    SequenceCaution:
    • Sequence=AAD34080.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG36937.1; Type=Frameshift; Positions=233, 249, 254, 272; Evidence={ECO:0000305}; Sequence=AAH98121.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAI04484.1; Type=Frameshift; Positions=396; Evidence={ECO:0000305}; Sequence=BAA90905.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUV420H1 Gene

    Alternative splice isoforms for SUV420H1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUV420H1 Gene

Proteomics data for SUV420H1 Gene at MOPED

Post-translational modifications for SUV420H1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SUV420H1 Gene

Domains for SUV420H1 Gene

Gene Families for SUV420H1 Gene

HGNC:
  • KMT :Chromatin-modifying enzymes / K-methyltransferases

Protein Domains for SUV420H1 Gene

Suggested Antigen Peptide Sequences for SUV420H1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4FZB7

UniProtKB/Swiss-Prot:

SV421_HUMAN :
  • Q4FZB7
Domain:
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
genes like me logo Genes that share domains with SUV420H1: view

Function for SUV420H1 Gene

Molecular function for SUV420H1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
UniProtKB/Swiss-Prot Function: Histone methyltransferase that specifically trimethylates Lys-20 of histone H4. H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.
UniProtKB/Swiss-Prot Induction: Strongly down-regulated in breast cancer cells.

Enzyme Numbers (IUBMB) for SUV420H1 Gene

Gene Ontology (GO) - Molecular Function for SUV420H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0018024 histone-lysine N-methyltransferase activity IDA 17707234
GO:0042799 histone methyltransferase activity (H4-K20 specific) IEA --
genes like me logo Genes that share ontologies with SUV420H1: view
genes like me logo Genes that share phenotypes with SUV420H1: view

Animal Models for SUV420H1 Gene

MGI Knock Outs for SUV420H1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUV420H1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for SUV420H1 Gene

Localization for SUV420H1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUV420H1 Gene

Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUV420H1 Gene COMPARTMENTS Subcellular localization image for SUV420H1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SUV420H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000780 condensed nuclear chromosome, centromeric region IEA --
genes like me logo Genes that share ontologies with SUV420H1: view

Pathways for SUV420H1 Gene

genes like me logo Genes that share pathways with SUV420H1: view

Pathways by source for SUV420H1 Gene

1 BioSystems pathway for SUV420H1 Gene
1 KEGG pathway for SUV420H1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SUV420H1 Gene

Gene Ontology (GO) - Biological Process for SUV420H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007517 muscle organ development IEA --
GO:0016571 histone methylation --
GO:0034770 histone H4-K20 methylation --
genes like me logo Genes that share ontologies with SUV420H1: view

Compounds for SUV420H1 Gene

(2) HMDB Compounds for SUV420H1 Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with SUV420H1: view

Transcripts for SUV420H1 Gene

Unigene Clusters for SUV420H1 Gene

Suppressor of variegation 4-20 homolog 1 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUV420H1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUV420H1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - - - - - - -
SP7:
SP8: - -
SP9: -

Relevant External Links for SUV420H1 Gene

GeneLoc Exon Structure for
SUV420H1
ECgene alternative splicing isoforms for
SUV420H1

Expression for SUV420H1 Gene

mRNA expression in normal human tissues for SUV420H1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SUV420H1 Gene

SOURCE GeneReport for Unigene cluster for SUV420H1 Gene Hs.632120

genes like me logo Genes that share expressions with SUV420H1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SUV420H1 Gene

Orthologs for SUV420H1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUV420H1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUV420H1 35
  • 99.77 (n)
  • 99.66 (a)
SUV420H1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUV420H1 35
  • 95.41 (n)
  • 96.94 (a)
SUV420H1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUV420H1 35
  • 88.64 (n)
  • 91.17 (a)
SUV420H1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Suv420h1 35
  • 85.42 (n)
  • 87.84 (a)
Suv420h1 16
Suv420h1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUV420H1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUV420H1 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Suv420h1 35
  • 86.3 (n)
  • 87.85 (a)
chicken
(Gallus gallus)
Aves SUV420H1 35
  • 80.76 (n)
  • 83.85 (a)
SUV420H1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUV420H1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1754 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16943 35
suv420h1 35
  • 72.79 (n)
  • 75.69 (a)
zebrafish
(Danio rerio)
Actinopterygii suv420h1 35
  • 60.24 (n)
  • 61.55 (a)
suv420h1 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hmt4-20 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea set-4 35
  • 50.96 (n)
  • 47.51 (a)
set-4 36
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9369 36
  • 60 (a)
OneToMany
Species with no ortholog for SUV420H1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUV420H1 Gene

ENSEMBL:
Gene Tree for SUV420H1 (if available)
TreeFam:
Gene Tree for SUV420H1 (if available)

Paralogs for SUV420H1 Gene

Paralogs for SUV420H1 Gene

genes like me logo Genes that share paralogs with SUV420H1: view

Variants for SUV420H1 Gene

Sequence variations from dbSNP and Humsavar for SUV420H1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs962297 -- 68,194,492(+) CCGGC(C/G)AAGTG intron-variant
rs1114399 -- 68,166,175(+) AACTA(A/C)AGAAA intron-variant, utr-variant-3-prime
rs1139104 -- 68,154,926(-) ACAAA(C/T)ATTTT utr-variant-3-prime
rs1540209 -- 68,161,053(-) TCTTG(G/T)TTCAA intron-variant
rs1685693 -- 68,175,406(+) TTTTA(A/G)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUV420H1 Gene

Variant ID Type Subtype PubMed ID
nsv825963 CNV Gain 20364138
nsv825966 CNV Gain 20364138

Relevant External Links for SUV420H1 Gene

HapMap Linkage Disequilibrium report
SUV420H1
Human Gene Mutation Database (HGMD)
SUV420H1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUV420H1 Gene

Disorders for SUV420H1 Gene

Relevant External Links for SUV420H1

Genetic Association Database (GAD)
SUV420H1
Human Genome Epidemiology (HuGE) Navigator
SUV420H1
genes like me logo Genes that share disorders with SUV420H1: view

No data available for UniProtKB/Swiss-Prot for SUV420H1 Gene

Publications for SUV420H1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13. (PMID: 11401438) Twells R.C.J. … Hess J.F. (Genomics 2001) 2 3 4
  3. FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis. (PMID: 23720823) Neguembor M.V. … Gabellini D. (J Mol Cell Biol 2013) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins. (PMID: 16322686) Tryndyak V.P. … Pogribny I.P. (Cancer Biol. Ther. 2006) 3 4

Products for SUV420H1 Gene

Sources for SUV420H1 Gene

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