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SUV420H1 Gene

protein-coding   GIFtS: 56
GCID: GC11M067922

Suppressor Of Variegation 4-20 Homolog 1 (Drosophila)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor Of Variegation 4-20 Homolog 1 (Drosophila)1 2     Histone-Lysine N-Methyltransferase SUV420H12
Lysine N-Methyltransferase 5B2 3     suv4-20h12
Su(Var)4-20 Homolog 12 3     EC 2.1.1.433
KMT5B2 3     Suv4-20h13
CGI852 5     Suppressor Of Variegation 4-20 Homolog 13
C630029K18Rik2     

External Ids:    HGNC: 242831   Entrez Gene: 511112   Ensembl: ENSG000001100667   OMIM: 6108815   UniProtKB: Q4FZB73   

Export aliases for SUV420H1 gene to outside databases

Previous GC identifers: GC11M067680 GC11M064258


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SUV420H1 Gene:
This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction
domains that mediate interactions with a family of proteins that display similarity with dual-specificity
phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript
variants have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SUV420H1 Gene:
SUV420H1 (suppressor of variegation 4-20 homolog 1 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include histone methyltransferase activity (H4-K20 specific) and histone-lysine N-methyltransferase activity. An important paralog of this gene is SUV420H2.

UniProtKB/Swiss-Prot: SV421_HUMAN, Q4FZB7
Function: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20'
trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in
pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive
heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins
(RB1, RBL1 and RBL2) (By similarity)

Gene Wiki entry for SUV420H1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUV420H1 gene promoter:
         NRSF form 1   Chx10   NRSF form 2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SUV420H1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUV420H1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

SUV420H1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUV420H1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M067922:  view genomic region     (about GC identifiers)

Start:
67,922,330 bp from pter      End:
67,981,295 bp from pter
Size:
58,966 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SV421_HUMAN, Q4FZB7 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SUV420H1  
Size: 885 amino acids; 99187 Da
Subunit: Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2
(By similarity)
Sequence caution: Sequence=AAD34080.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAG36937.1; Type=Frameshift; Positions=233, 249, 254, 272; Sequence=AAH98121.1; Type=Erroneous
translation; Note=Wrong choice of frame; Sequence=AAI04484.1; Type=Frameshift; Positions=396;
Sequence=BAA90905.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for SUV420H1:
3S8P (3D)    
Secondary accessions: B7WNX7 Q3SX56 Q4V775 Q6P150 Q96E44 Q9BUL0 Q9H022 Q9H2K3 Q9NXV3 Q9Y393
Alternative splicing: 3 isoforms:  Q4FZB7-1   Q4FZB7-2   Q4FZB7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SUV420H1: NX_Q4FZB7

Explore proteomics data for SUV420H1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SUV420H1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_057112.3  NP_060105.3  

    ENSEMBL proteins: 
     ENSP00000305899   ENSP00000411146   ENSP00000387685   ENSP00000385965   ENSP00000385640  
     ENSP00000385005   ENSP00000384724   ENSP00000313027   ENSP00000433589   ENSP00000406377  
     ENSP00000403233   ENSP00000402921  

    SUV420H1 Human Recombinant Protein Products:

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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SUV420H1
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    Novus Biologicals SUV420H1 Protein
    Novus Biologicals SUV420H1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUV420H1

     
    Search eBioscience for Proteins for SUV420H1 

    SUV420H1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for SUV420H1
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    LSBio Antibodies in human, mouse, rat for SUV420H1

    SUV420H1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SUV420H1
    Cloud-Clone Corp. CLIAs for SUV420H1
    Search eBioscience for ELISAs for SUV420H1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KMT: Chromatin-modifying enzymes / K-methyltransferases

    2 InterPro protein domains:
     IPR025790 Hist-Lys_N-MTase_Suvar4-20
     IPR001214 SET_dom

    Graphical View of Domain Structure for InterPro Entry Q4FZB7

    ProtoNet protein and cluster: Q4FZB7

    UniProtKB/Swiss-Prot: SV421_HUMAN, Q4FZB7
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. Suvar4-20 subfamily
    Similarity: Contains 1 SET domain


    Find genes that share domains with SUV420H1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SV421_HUMAN, Q4FZB7
    Function: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20'
    trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in
    pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive
    heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins
    (RB1, RBL1 and RBL2) (By similarity)
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]
    Induction: Strongly down-regulated in breast cancer cells

         Enzyme Number (IUBMB): EC 2.1.1.431

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0018024histone-lysine N-methyltransferase activity IDA17707234
    GO:0042799histone methyltransferase activity (H4-K20 specific) IEA--
         
    Find genes that share ontologies with SUV420H1           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for SUV420H1:
     Decreased Salmonella enterica   Decreased Wnt reporter activit  Decreased p24 protein expressi  Increased S DNA content 
     Increased circadian rhythm amp  Synthetic lethal with Ras 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Suv420h1):
     adipose tissue  cellular  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  respiratory system  skeleton 

    Find genes that share phenotypes with SUV420H1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Suv420h1tm1.1Jnw for SUV420H1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUV420H1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SUV420H1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUV420H1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUV420H1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SUV420H1:
    hsa-mir-128-3p (MIRT045876), hsa-mir-19b-3p (MIRT031143), hsa-mir-93-5p (MIRT028080), hsa-mir-21-3p (MIRT038965), hsa-mir-32-5p (MIRT028330), hsa-mir-130b-3p (MIRT020188), hsa-mir-590-3p (MIRT016220), hsa-mir-27a-3p (MIRT028707)

    Block miRNA regulation of human, mouse, rat SUV420H1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUV420H1 (see all 46):
    hsa-miR-345 hsa-miR-300 hsa-miR-513a-5p hsa-miR-548k hsa-miR-29a hsa-miR-25 hsa-miR-301a hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmidSUV420H1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SUV420H1
    Predesigned siRNA for gene silencing in human, mouse, rat SUV420H1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SUV420H1 (NM_017635)
    Sino Biological Human cDNA Clone for SUV420H1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUV420H1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUV420H1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV420H1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SV421_HUMAN, Q4FZB7: Nucleus. Chromosome (By similarity). Note=Associated with pericentric heterochromatin. CBX1
    and CBX5 are required for the localization to pericentric heterochromatin (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000780condensed nuclear chromosome, centromeric region IEA--

    Find genes that share ontologies with SUV420H1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SUV420H1 About    
    See pathways by source

    SuperPathContained pathways About
    1Lysine degradation
    Lysine degradation
    2Glucocorticoid receptor regulatory network
    Glucocorticoid receptor regulatory network


    Find genes that share SuperPaths with SUV420H1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SUV420H1
        Glucocorticoid receptor regulatory network



    1 Kegg Pathway  (Kegg details for SUV420H1):
        Lysine degradation

        Pathway & Disease-focused RT2 Profiler PCR Array including SUV420H1: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SUV420H1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for SUV420H1 (Q4FZB73 ENSP000003058994) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=1 STRING: ENSP00000289352
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4FP628053, ENSP000003669744I2D: score=1 STRING: ENSP00000366974
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0016571histone methylation ----
    GO:0034770histone H4-K20 methylation ----
    GO:0034773histone H4-K20 trimethylation IEA--

    Find genes that share ontologies with SUV420H1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUV420H1 (SV421)

    2 HMDB Compounds for SUV420H1    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SUV420H1 gene (2 alternative transcripts): 
    NM_016028.4  NM_017635.3  

    Unigene Cluster for SUV420H1:

    Suppressor of variegation 4-20 homolog 1 (Drosophila)
    Hs.632120  [show with all ESTs]
    Unigene Representative Sequence: NM_017635
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304363(uc009yse.1 uc001onm.1 uc001onn.1 uc009ysf.2)
    ENST00000441488 ENST00000427752 ENST00000401547(uc001ono.1) ENST00000405515(uc010rqa.1)
    ENST00000402789 ENST00000402185 ENST00000323599 ENST00000533271 ENST00000524672
    ENST00000453170 ENST00000458496 ENST00000434573 ENST00000466295
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SUV420H1 (see all 46):
    hsa-miR-345 hsa-miR-300 hsa-miR-513a-5p hsa-miR-548k hsa-miR-29a hsa-miR-25 hsa-miR-301a hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmidSUV420H1 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): SUV420H1 (NM_017635)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUV420H1
    Primer
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    OriGene qPCR primer pairs and template standards for SUV420H1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUV420H1
      QuantiTect SYBR Green Assays in human, mouse, rat SUV420H1
      QuantiFast Probe-based Assays in human, mouse, rat SUV420H1

    Additional mRNA sequence: 

    AF151843.1 AF264782.1 AK000046.1 AK025183.1 AK025461.1 AK026428.1 AK225203.1 AK299201.1 
    AK314336.1 AL512763.1 BC002522.2 BC012933.1 BC065287.1 BC087834.1 BC098121.1 BC099714.1 
    BC103498.1 BC104483.1 BC108304.1 

    17 DOTS entries:

    DT.316911  DT.441923  DT.95343552  DT.455671  DT.100792656  DT.95280252  DT.95280254  DT.120711047 
    DT.100792650  DT.100792651  DT.120711049  DT.95149014  DT.100723574  DT.120711032  DT.86999879  DT.91866722 
    DT.100884527 

    Selected AceView cDNA sequences (see all 362):

    AI092873 F01880 BU076258 AA360188 AW473298 BM857287 CD519572 AI474398 
    BM718574 W67880 N50821 BQ069570 BC065287 BM725783 AI659791 BQ269751 
    AW026767 AI685930 AI624933 AA810205 BM833502 Z40898 NM_016028 Z42360 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SUV420H1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16
    SP1:                                                                    -     -                       -                                                   
    SP2:              -     -                                               -     -                       -                                                   
    SP3:                    -                                               -     -                                                                           
    SP4:                                                                    -     -                       -           -                                       
    SP5:                                                                    -     -                                                                           


    ECgene alternative splicing isoforms for SUV420H1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SUV420H1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTCCTGAA
    SUV420H1 Expression
    About this image


    SUV420H1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
    SUV420H1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUV420H1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632120
        Pathway & Disease-focused RT2 Profiler PCR Array including SUV420H1: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SUV420H1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUV420H1
    QuantiTect SYBR Green Assays in human, mouse, rat SUV420H1
    QuantiFast Probe-based Assays in human, mouse, rat SUV420H1
    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SUV420H1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Suv420h11 , 5 suppressor of variegation 4-20 homolog 1 (Drosophila)1, 5 85.42(n)1
    87.84(a)1
      19 (3.50 cM)5
    2258881  NM_001167887.11  NP_001161359.11 
     37674215 
    chicken
    (Gallus gallus)
    Aves SUV420H11 suppressor of variegation 4-20 homolog 1 (Drosophila) 80.76(n)
    83.85(a)
      425119  XM_422910.4  XP_422910.4 
    lizard
    (Anolis carolinensis)
    Reptilia SUV420H16
    suppressor of variegation 4-20 homolog 1 (Drosophi...
    81(a)
    1 ↔ 1
    1(75144119-75159974)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.17542 Xenopus laevis transcribed sequence with moderate similarity more 79.17(n)    BX848518.1 
    zebrafish
    (Danio rerio)
    Actinopterygii suv420h11 suppressor of variegation 4-20 homolog 1 (Drosophila) 60.24(n)
    61.55(a)
      572849  NM_001007337.2  NP_001007338.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hmt4-206
    Histone methyltransferase 4-20
    19(a)
    1 → many
    X(542516-550075)
    worm
    (Caenorhabditis elegans)
    Secernentea set-41 set-4 50.96(n)
    47.51(a)
      174045  NM_062871.4  NP_495272.1 


    ENSEMBL Gene Tree for SUV420H1 (if available)
    TreeFam Gene Tree for SUV420H1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUV420H1 gene
    SUV420H22  
    Selected SIMAP similar genes for SUV420H1 using alignment to 9 protein entries:     SV421_HUMAN (see all proteins) (see all similar genes):
    EEF1E1    RHOA    ABI2    DPP9    MST132    LSM12
    SH2B3    ZNF180    C12orf76    GALK2    NLN    RQCD1
    TUBA1C    COQ5    FLJ00047    ARIH1    ZNF114    CDK10

    Find genes that share paralogs with SUV420H1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SUV420H1 (see all 1202)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1441715241,2
    C--64268160(+) AGTGGC/TTCACA 1 -- ds50010--------
    rs356804471,2
    C,F--64268225(+) GAGATC/TGAGAC 1 -- ds50012Minor allele frequency- T:0.50NA 4
    rs1887004681,2
    --64268278(+) CAAAAA/TTTAGC 1 -- ds50010--------
    rs1811266411,2
    --64268305(+) TGCCTC/GTAATC 1 -- ds50010--------
    rs1839496771,2
    --64268413(+) CAGAGC/TGAGAC 1 -- ds50010--------
    rs1882829011,2
    --64268421(+) GACTCC/TGTCTC 1 -- ds50010--------
    rs1408045281,2
    C--64268458(+) TCTTAC/GTATGT 1 -- ds50010--------
    rs1431225141,2
    --64268497(+) CTCAAC/GTGACC 1 -- ds50010--------
    rs3734046611,2
    C--64268556(+) GCCTGA/GTTTTA 1 -- ds50010--------
    rs1466997421,2
    C--64268750(+) CTACAA/GCGCTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SUV420H1 (67922330 - 67981295 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SUV420H1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv825963CNV Gain20364138
    nsv825966CNV Gain20364138

    Human Gene Mutation Database (HGMD): SUV420H1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUV420H1
    DNA2.0 Custom Variant and Variant Library Synthesis for SUV420H1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610881    OMIM disorders: --


    Find genes that share disorders with SUV420H1           About GenesLikeMe

    Genetic Association Database (GAD): SUV420H1
    Human Genome Epidemiology (HuGE) Navigator: SUV420H1 (1 document)

    Export disorders for SUV420H1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUV420H1 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with SUV420H1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13. (PubMed id 11401438)1, 2, 3 Twells R.C.J.... Hess J.F. (Genomics 2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    3. Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins. (PubMed id 16322686)1, 2 Tryndyak V.P.... Pogribny I.P. (Cancer Biol. Ther. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    7. Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2. (PubMed id 24396869)1 Wu H....Min J. (FEBS Lett. 2013)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    10. Comparative analyses of SUV420H1 isoforms and SUV420H2 reveal differences in their cellular localization and effects on myogenic differentiation. (PubMed id 21206904)1 Tsang L.W....Underhill D.A. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51111 HGNC: 24283 AceView: SUV420H1 Ensembl:ENSG00000110066 euGenes: HUgn51111
    ECgene: SUV420H1 Kegg: 51111 H-InvDB: SUV420H1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SUV420H1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SUV420H1 gene:
    Search GeneIP for patents involving SUV420H1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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