Aliases for SUV420H1 Gene
External Ids for SUV420H1 Gene
Previous GeneCards Identifiers for SUV420H1 Gene
This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
GeneCards Summary for SUV420H1 Gene
SUV420H1 (Suppressor Of Variegation 4-20 Homolog 1 (Drosophila)) is a Protein Coding gene. Among its related pathways are Glucocorticoid receptor regulatory network and Lysine degradation. GO annotations related to this gene include histone-lysine N-methyltransferase activity and histone methyltransferase activity (H4-K20 specific). An important paralog of this gene is SUV420H2.
UniProtKB/Swiss-Prot for SUV420H1 Gene
Histone methyltransferase that specifically trimethylates Lys-20 of histone H4. H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.