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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUV39H2 Gene

protein-coding   GIFtS: 64
GCID: GC10P014922

suppressor of variegation 3-9 homolog 2 (Drosophila)
 Explore 3 diseases affiliated with
SUV39H2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SUV39H2    

Aliases
for SUV39H2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Suppressor Of Variegation 3-9 Homolog 2 (Drosophila)1 2     H3-K9-HMTase 22 3
KMT1B1 2 3     EC 2.1.1.433 8
Histone H3-K9 Methyltransferase 22 3     FLJ234141 5
Lysine N-Methyltransferase 1B2 3     Histone-Lysine N-Methyltransferase SUV39H22
Su(Var)3-9 Homolog 22 3     Suppressor Of Variegation 3-9 Homolog 23

External Ids:    HGNC: 172871   Entrez Gene: 797232   Ensembl: ENSG000001524557   OMIM: 6065035   UniProtKB: Q9H5I13   
ORGUL members:         
NONCODE:n409777    

Export aliases for SUV39H2 gene to outside databases

Previous GC identifers: GC10P014903 GC10P015071 GC10P014924 GC10P014960 GC10P014921 GC10P014831


Summaries
for SUV39H2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SUV92_HUMAN, Q9H5I1
Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3
'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by
recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions,
thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere
regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is
targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation,
transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin
organization during spermatogenesis

Gene Wiki entry for SUV39H2


Genomic Views
for SUV39H2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUV39H2 gene promoter:
         Nkx3-1   Sox5   Nkx3-1 v1   POU6F1 (c2)   Evi-1   FOXL1   Nkx3-1 v2   Nkx3-1 v3   MRF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SUV39H2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SUV39H2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUV39H2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

SUV39H2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUV39H2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P014922:  view genomic region     (about GC identifiers)

Start:
 14,920,782 bp from pter      End:
 14,946,314 bp from pter
Size:
 25,533 bases      Orientation:
 plus strand

Proteins
for SUV39H2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SUV92_HUMAN, Q9H5I1 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SUV39H2  
Size: 410 amino acids; 46682 Da
Subunit: Interacts with SMAD5
Subcellular location: Nucleus (By similarity). Chromosome, centromere (By similarity). Note=Associates with centromeric
constitutive heterochromatin (By similarity)
1 PDB 3D structure from and Proteopedia for SUV39H2:
2R3A (3D)    
Secondary accessions: D3DRT4 Q5JSS4 Q5JSS5 Q6I9Y3 Q8ND06
Alternative splicing: 3 isoforms:  Q9H5I1-1   Q9H5I1-2   Q9H5I1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SUV39H2: NX_Q9H5I1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H5I1

    • 4/20 DME Specific Peptides for SUV39H2 (Q9H5I1) (see all 20)
     QIKIPPG  KNHKGMI  TVCKCGA  EYYLVKW 

    SUV39H2 Protein expression data from MOPED and PaxDb:    About this image 
    SUV39H2 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001180353.1  NP_001180354.1  NP_001180355.1  NP_001180356.1  NP_078946.1  

    ENSEMBL proteins: 
     ENSP00000367582   ENSP00000388968   ENSP00000367576   ENSP00000346997   ENSP00000319208  
     ENSP00000392201   ENSP00000388218   ENSP00000351046  

    Human Recombinant Protein Products for SUV39H2: 
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    OriGene Protein Over-expression Lysate: SUV39H2
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    Novus Biologicals SUV39H2 Protein
    Novus Biologicals SUV39H2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SUV39H2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000785chromatin IDA10949293
    GO:0005634nucleus ----
    GO:0005720nuclear heterochromatin IEA--

    SUV39H2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SUV39H2

    Protein Domains /
    Families
    for SUV39H2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SUV39H2 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR001214 SET_dom
     IPR003616 Post-SET_dom
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9H5I1

    ProtoNet protein and cluster: Q9H5I1

    4 Blocks protein families:
    IPB000953 Chromo domain
    IPB001214 Nuclear protein SET
    IPB003606 Nuclear protein Zn2+-binding
    IPB003616 SET-related region


    UniProtKB/Swiss-Prot: SUV92_HUMAN, Q9H5I1
    Domain: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are
    required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin (By
    similarity)
    Similarity: Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily
    Similarity: Contains 1 chromo domain
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 pre-SET domain
    Similarity: Contains 1 SET domain


    Function
    for SUV39H2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUV92_HUMAN, Q9H5I1
    Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3
    'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by
    recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions,
    thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere
    regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is
    targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation,
    transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin
    organization during spermatogenesis
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Number (IUBMB): EC 2.1.1.431 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI17474147
    GO:0008168methyltransferase activity ----
    GO:0008270zinc ion binding IEA--
    GO:0008276protein methyltransferase activity ----
         
    SUV39H2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SUV39H2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Synthetic lethal with Ras 
     Upregulation of Wnt/beta-caten 

         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Suv39h2):
     embryogenesis  growth/size  mortality/aging  reproductive system  tumorigenesis 

    SUV39H2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SUV39H2 

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUV39H2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate SUV39H2 (see all 18):
    hsa-miR-30c hsa-miR-496 hsa-miR-30d hsa-miR-548s hsa-miR-3653 hsa-miR-30a hsa-miR-3658 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmid: SUV39H2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUV39H2 (see all 7)
    OriGene shRNA RFP: SUV39H2
    OriGene siRNA: SUV39H2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUV39H2
    Sirion Biotech Custom design and validation of potent shRNA sequences against SUV39H2 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SUV39H2
    Sirion Biotech Customized adenovirus for overexpression of SUV39H2 
    Sirion Biotech Customized adenovirus for potent knockdown of SUV39H2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUV39H2 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    Sino Biological Human cDNA Clone for SUV39H2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUV39H2 

    Cell Line
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    Sirion Biotech Customized inducible overexpressing cell line services for SUV39H2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV39H2


    Pathways & Interactions
    for SUV39H2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lysine degradation
    		Lysine degradation1.00
    2Signal transduction Activin A signaling regulation
    		Histone modification0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SUV39H2
        Histone modification



    1         Kegg Pathway  (Kegg details for SUV39H2):
        Lysine degradation


    SUV39H2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SUV39H2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/32 Interacting proteins for SUV39H2 (Q9H5I11, 2, 3 ENSP000003192084) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110815 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111583 I2D: score=3 STRING: ENSP00000357656
    PIK3R1P279862, 3, ENSP000002743354MINT-8112303 I2D: score=3 STRING: ENSP00000274335
    PLCG1P191742, 3, ENSP000002440074MINT-8112819 I2D: score=3 STRING: ENSP00000244007
    CEP70Q8NHQ12, 3MINT-8272454 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006333chromatin assembly or disassembly IMP10949293
    GO:0006338chromatin remodeling IDA10949293
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006479protein methylation ----

    SUV39H2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SUV39H2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUV39H2

    2 HMDB Compounds for SUV39H2    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Search CenterWatch for drugs/clinical trials and news about SUV39H2 / SUV92 

    Transcripts
    for SUV39H2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SUV39H2 gene (5 alternative transcripts): 
    NM_001193424.1  NM_001193425.1  NM_001193426.1  NM_001193427.1  NM_024670.3  

    Unigene Cluster for SUV39H2:

    Suppressor of variegation 3-9 homolog 2 (Drosophila)
    Hs.554883  [show with all ESTs]
    Unigene Representative Sequence: NM_001193424
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378331(uc021png.1 uc001ing.3 uc001inh.3) ENST00000433779
    ENST00000378325 ENST00000354919 ENST00000313519(uc001ini.3 uc021pnh.1 uc001inj.3)
    ENST00000420416 ENST00000412254 ENST00000358298

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUV39H2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate SUV39H2 (see all 18):
    hsa-miR-30c hsa-miR-496 hsa-miR-30d hsa-miR-548s hsa-miR-3653 hsa-miR-30a hsa-miR-3658 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmid: SUV39H2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUV39H2 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK027067.1 AK222565.1 AK225369.1 AL834488.1 BC007754.2 BC029360.1 CR457372.1 NR_034181.1 

    9 DOTS entries:

    DT.95178104  DT.110472  DT.95169804  DT.40119293  DT.100781428  DT.100751441  DT.121264001  DT.92424102 
    DT.100730668 

    24/87 AceView cDNA sequences (see all 87):

    AA232651 BM806112 BI543228 AL557161 AI340335 AA507430 CR602124 CA448749 
    AL834488 BM801054 CA426280 CR615952 BI488686 AA236468 AK027067 AI888878 
    AL519134 AW518089 BM468558 BQ422352 CR607132 AI347262 BX337528 CR590158 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SUV39H2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
    SP1:                    -     -                                 
    SP2:                          -                                 
    SP3:                                                            
    SP4:                    -     -     -                           


    ECgene alternative splicing isoforms for SUV39H2

    Expression
    for SUV39H2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUV39H2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCAAGACA
    SUV39H2 Expression
    About this image

    SUV39H2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Paraxial Mesoderm CellsBone, Skeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SUV39H2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUV39H2

    SOURCE GeneReport for Unigene cluster: Hs.554883
        SABiosciences Custom PCR Arrays for SUV39H2
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUV39H2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV39H2

    Orthologs
    for SUV39H2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUV39H2 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Suv39h21 , 5 suppressor of variegation 3-9 homolog 2 (Drosophila)1, 5 88.22(n)1
    90.66(a)1    		   2 (1.95 cM)5
    647071  NM_022724.41  NP_073561.21 
     34558155 
    chicken
    (Gallus gallus)    		 Aves SUV39H21 suppressor of variegation 3-9 homolog 2 (Drosophila) 79.44(n)
    78.61(a)    		   426314  NM_001031370.2  NP_001026541.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.192442 Xenopus laevis transcribed sequence with weak similarity more 74.78(n)    BJ634014.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufe02c042 Transcribed sequence with moderate similarity to protein more 75.56(n)    57059912 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Su(var)3-93 translational initiation translation
    initiation more    		 34(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea set-256
    set-116
    		 SET (trithorax/polycomb) domain containing family ...
    SET (trithorax/polycomb) domain containing family ...
    		 8(a)
    19(a)
    		 possible ortholog
    possible ortholog
    		 III(13283791-13292984)
    II(2690477-2694316)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SDG216
    SUVH56
    (see all 16)    		 histone-lysine N-methyltransferase, H3 lysine-9 sp...
    histone-lysine N-methyltransferase, H3 lysine-9 sp...
    (see all 16)    		 9(a)
    9(a)
    (see all 16)    		 possible ortholog
    possible ortholog
    (see all 16)    		 2(10529690-10531957)
    2(14822824-14826162)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 17)    		 SET domain containing protein, expressed
    histone-lysine N-methyltransferase, putative, expr...
    (see all 17)    		 9(a)
    9(a)
    (see all 17)    		 possible ortholog
    possible ortholog
    (see all 17)    		 2(24702116-24711432)
    4(27058948-27061661)


    ENSEMBL Gene Tree for SUV39H2 (if available)
    TreeFam Gene Tree for SUV39H2 (if available) 

    Paralogs
    for SUV39H2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUV39H2 gene
    NSD12  EZH12  WHSC12  WHSC1L12  SETDB22  SETD22  SUV39H12  EHMT12  
    EHMT22  EZH22  SETDB12  
    11 SIMAP similar genes for SUV39H2 using alignment to 6 protein entries:     SUV92_HUMAN (see all proteins):
    SUV39H1    CBX5    EHMT1    CBX4    EHMT2    EZH2
    FP13812    MLL    CBX1    MLL4    DKFZp686C08112

    SUV39H2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SUV39H2
    PGOHUM00000243662 PGOHUM00000241323


    Genomic Variants
    for SUV39H2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/491 NCBI SNPs in SUV39H2 are shown (see all 491)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1456536591,2
    		--14918804(+) GCCGGC/TCATCT 3 -- us2k10--------
    rs1163872461,2
    		--14918837(+) ATGCTA/GCGAAG 3 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1381148831,2
    		--14918869(+) ATATGC/TTCAAT 5 -- us2k10--------
    rs1896097151,2
    		--14918892(+) TGCAAC/TACCTA 5 -- us2k10--------
    rs1427054121,2
    		--14919089(+) GAACCA/CAGGTT 6 -- us2k10--------
    rs1459998851,2
    		--14919100(+) GGACTC/GAGGAA 6 -- us2k10--------
    rs1157079721,2
    		--14919139(+) CAGTGA/GGTAGC 6 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1818613891,2
    		--14919191(+) GTAATG/TAATAC 6 -- us2k10--------
    rs1839664921,2
    		--14919203(+) GGGGCC/TGGTTA 6 -- us2k10--------
    rs1132827411,2
    		--14919220(+) GAGGCC/TGTATC 6 -- us2k11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for SUV39H2 (14920782 - 14946314 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for SUV39H2
         4 Indels: 42792 44709 60990 39725

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SUV39H2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SUV39H2 for disorders           About GeneDecksing

    OMIM gene information: 606503    OMIM disorders: --

    3 diseases for SUV39H2:    About MalaCards
    homocysteine    lung cancer    hypoxia

    Human Genome Epidemiology (HuGE) Navigator: SUV39H2 (2 documents)

    Export disorders for SUV39H2 gene to outside databases

    Publications
    for SUV39H2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUV39H2 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with SUV39H2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. (PubMed id 11094092)1, 3, 9 O'Carroll D....Jenuwein T. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells. (PubMed id 14765126)1, 2 Ait-Si-Ali S.... Harel-Bellan A. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    6. Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression. (PubMed id 15107829)1, 2 Frontelo P....Lechleider R.J. (2004)
    7. Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer. (PubMed id 16774942)1, 9 Yoon K.A....Lee J.S. (2006)
    8. Genetic examination of SETD7 and SUV39H1/H2 methyltra nsferases and the risk of diabetes complications in patients with type 1 diabet es. (PubMed id 21896933)1 Syreeni A....Groop P.H. (2011)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    External Searches for SUV39H2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SUV39H2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79723 HGNC: 17287 AceView: SUV39H2 Ensembl:ENSG00000152455 euGenes: HUgn79723
    ECgene: SUV39H2 Kegg: 79723 H-InvDB: SUV39H2

    Other Databases showing SUV39H2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SUV39H2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUV39H2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SUV39H2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SUV39H2 gene:
    Search GeneIP for patents involving SUV39H2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SUV39H2 gene

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    About This Section

     
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