Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUV39H2 Gene

protein-coding   GIFtS: 65
GCID: GC10P014922

Suppressor Of Variegation 3-9 Homolog 2 (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Suppressor Of Variegation 3-9 Homolog 2 (Drosophila)1 2     H3-K9-HMTase 22 3
Histone H3-K9 Methyltransferase 22 3     EC 2.1.1.433 8
Lysine N-Methyltransferase 1B2 3     Histone-Lysine N-Methyltransferase SUV39H22
Su(Var)3-9 Homolog 22 3     Suppressor Of Variegation 3-9 Homolog 23
KMT1B2 3     FLJ234145

External Ids:    HGNC: 172871   Entrez Gene: 797232   Ensembl: ENSG000001524557   OMIM: 6065035   UniProtKB: Q9H5I13   
ORGUL members:         
NONCODE14:n409777      

Export aliases for SUV39H2 gene to outside databases

Previous GC identifers: GC10P014903 GC10P015071 GC10P014924 GC10P014960 GC10P014921 GC10P014831


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SUV39H2 Gene: 
SUV39H2 (suppressor of variegation 3-9 homolog 2 (Drosophila)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with SUV39H2 include type 1 diabetes, and hypoxia, and among its related super-pathways are Signal transduction Activin A signaling regulation. GO annotations related to this gene include chromatin binding and histone methyltransferase activity (H3-K9 specific). An important paralog of this gene is NSD1.

UniProtKB/Swiss-Prot: SUV92_HUMAN, Q9H5I1
Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3
'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional
repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in
heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at
pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at
pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many
processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May
participate in regulation of higher-order chromatin organization during spermatogenesis

Gene Wiki entry for SUV39H2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUV39H2 gene promoter:
         Nkx3-1   Sox5   Nkx3-1 v1   POU6F1 (c2)   Evi-1   FOXL1   Nkx3-1 v2   Nkx3-1 v3   MRF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUV39H2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SUV39H2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUV39H2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

SUV39H2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUV39H2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P014922:  view genomic region     (about GC identifiers)

Start:
14,920,782 bp from pter      End:
14,946,314 bp from pter
Size:
25,533 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SUV92_HUMAN, Q9H5I1 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SUV39H2  
Size: 410 amino acids; 46682 Da
Subunit: Interacts with SMAD5
Subcellular location: Nucleus (By similarity). Chromosome, centromere (By similarity). Note=Associates with
centromeric constitutive heterochromatin (By similarity)
1 PDB 3D structure from and Proteopedia for SUV39H2:
2R3A (3D)    
Secondary accessions: D3DRT4 Q5JSS4 Q5JSS5 Q6I9Y3 Q8ND06
Alternative splicing: 3 isoforms:  Q9H5I1-1   Q9H5I1-2   Q9H5I1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SUV39H2: NX_Q9H5I1

Explore proteomics data for SUV39H2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H5I1

  • 4/20 DME Specific Peptides for SUV39H2 (Q9H5I1) (see all 20)
     QIKIPPG  KNHKGMI  TVCKCGA  EYYLVKW 

    SUV39H2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SUV39H2 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001180353.1  NP_001180354.1  NP_001180355.1  NP_001180356.1  NP_078946.1  

    ENSEMBL proteins: 
     ENSP00000367582   ENSP00000388968   ENSP00000367576   ENSP00000346997   ENSP00000319208  
     ENSP00000392201   ENSP00000388218   ENSP00000351046  

    Human Recombinant Protein Products for SUV39H2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SUV39H2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SUV39H2
    GenScript Custom Purified and Recombinant Proteins Services for SUV39H2
    Novus Biologicals SUV39H2 Protein
    Novus Biologicals SUV39H2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUV39H2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000785chromatin IDA10949293
    GO:0005634nucleus ----
    GO:0005720nuclear heterochromatin IEA--

    SUV39H2 for ontologies           About GeneDecksing



    SUV39H2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SUV39H2
    GenScript Custom Superior Antibodies Services for SUV39H2
    Novus Biologicals SUV39H2 Antibodies
    Abcam antibodies for SUV39H2
    Cloud-Clone Corp. Antibodies for SUV39H2 
    ThermoFisher Antibody for SUV39H2
    LSBio Antibodies in human, mouse, rat for SUV39H2 

    Assay Products for SUV39H2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SUV39H2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SUV39H2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SUV39H2 
    Cloud-Clone Corp. CLIAs for SUV39H2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KMT: Chromatin-modifying enzymes / K-methyltransferases

    5/8 InterPro protein domains (see all 8):
     IPR001214 SET_dom
     IPR003616 Post-SET_dom
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9H5I1

    ProtoNet protein and cluster: Q9H5I1

    4 Blocks protein domains:
    IPB000953 Chromo domain
    IPB001214 Nuclear protein SET
    IPB003606 Nuclear protein Zn2+-binding
    IPB003616 SET-related region


    UniProtKB/Swiss-Prot: SUV92_HUMAN, Q9H5I1
    Domain: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains
    are required for methyltransferase activity. The SET domain also participates to stable binding to
    heterochromatin (By similarity)
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. Suvar3-9 subfamily
    Similarity: Contains 1 chromo domain
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 pre-SET domain
    Similarity: Contains 1 SET domain


    SUV39H2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUV92_HUMAN, Q9H5I1
    Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3
    'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional
    repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in
    heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at
    pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at
    pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many
    processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May
    participate in regulation of higher-order chromatin organization during spermatogenesis
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Number (IUBMB): EC 2.1.1.431 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI17474147
    GO:0008168methyltransferase activity ----
    GO:0008270zinc ion binding IEA--
    GO:0008276protein methyltransferase activity ----
         
    SUV39H2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SUV39H2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Synthetic lethal with Ras 
     Upregulation of Wnt/beta-caten 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Suv39h2):
     embryogenesis  growth/size  mortality/aging  reproductive system  tumorigenesis 

    SUV39H2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SUV39H2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUV39H2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUV39H2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUV39H2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUV39H2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate SUV39H2 (see all 18):
    hsa-miR-30c hsa-miR-496 hsa-miR-30d hsa-miR-548s hsa-miR-3653 hsa-miR-30a hsa-miR-3658 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidSUV39H2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SUV39H2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUV39H2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SUV39H2
    Sirion Biotech Customized adenovirus for overexpression of SUV39H2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SUV39H2 (see all 15)
    OriGene ORF clones in mouse, rat for SUV39H2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): SUV39H2 (NM_001193427)
    Sino Biological Human cDNA Clone for SUV39H2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUV39H2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUV39H2
    Sirion Biotech Customized lentivirus for stable overexpression of SUV39H2 
                         Customized lentivirus expression plasmids for stable overexpression of SUV39H2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SUV39H2
    Search LifeMap BioReagents cell lines for SUV39H2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV39H2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SUV39H2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Histone modification0.31
    2Lysine degradation
    Lysine degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SUV39H2
        Histone modification




    1         Kegg Pathway  (Kegg details for SUV39H2):
        Lysine degradation


    SUV39H2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SUV39H2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/32 Interacting proteins for SUV39H2 (Q9H5I11, 2, 3 ENSP000003192084) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110815 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111583 I2D: score=3 STRING: ENSP00000357656
    PIK3R1P279862, 3, ENSP000002743354MINT-8112303 I2D: score=3 STRING: ENSP00000274335
    PLCG1P191742, 3, ENSP000002440074MINT-8112819 I2D: score=3 STRING: ENSP00000244007
    CEP70Q8NHQ12, 3MINT-8272454 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006333chromatin assembly or disassembly IMP10949293
    GO:0006338chromatin remodeling IDA10949293
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007140male meiosis IEA--

    SUV39H2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUV39H2 (SUV92)

    2 HMDB Compounds for SUV39H2    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    Search CenterWatch for drugs/clinical trials and news about SUV39H2 / SUV92

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUV39H2 gene (5 alternative transcripts): 
    NM_001193424.1  NM_001193425.1  NM_001193426.1  NM_001193427.1  NM_024670.3  

    Unigene Cluster for SUV39H2:

    Suppressor of variegation 3-9 homolog 2 (Drosophila)
    Hs.554883  [show with all ESTs]
    Unigene Representative Sequence: NM_001193424
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378331(uc021png.1 uc001ing.3 uc001inh.3) ENST00000433779
    ENST00000378325 ENST00000354919 ENST00000313519(uc001ini.3 uc021pnh.1 uc001inj.3)
    ENST00000420416 ENST00000412254 ENST00000358298
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUV39H2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate SUV39H2 (see all 18):
    hsa-miR-30c hsa-miR-496 hsa-miR-30d hsa-miR-548s hsa-miR-3653 hsa-miR-30a hsa-miR-3658 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidSUV39H2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SUV39H2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUV39H2
    Clone
    Products:
         
    OriGene clones in human, mouse for SUV39H2 (see all 15)
    OriGene ORF clones in mouse, rat for SUV39H2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): SUV39H2 (NM_001193427)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUV39H2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUV39H2
    Sirion Biotech Customized lentivirus for stable overexpression of SUV39H2 
                         Customized lentivirus expression plasmids for stable overexpression of SUV39H2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SUV39H2
    OriGene qSTAR qPCR primer pairs in human, mouse for SUV39H2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SUV39H2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUV39H2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUV39H2

    Additional mRNA sequence: 

    AK027067.1 AK222565.1 AK225369.1 AL834488.1 BC007754.2 BC029360.1 CR457372.1 NR_034181.1 

    9 DOTS entries:

    DT.95178104  DT.110472  DT.95169804  DT.40119293  DT.100781428  DT.100751441  DT.121264001  DT.92424102 
    DT.100730668 

    24/87 AceView cDNA sequences (see all 87):

    AA236468 AL834488 BG574641 AI888878 BM468558 AA507430 BX337528 CR590158 
    AI802158 CK904581 CA448749 AL519134 CR615952 AW518089 CR607132 BI488686 
    AI347262 CA426280 AI340335 BM806112 BI543228 AA232651 NM_024670 CB138745 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SUV39H2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
    SP1:                    -     -                                 
    SP2:                          -                                 
    SP3:                                                            
    SP4:                    -     -     -                           


    ECgene alternative splicing isoforms for SUV39H2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUV39H2 expression in normal human tissues (normalized intensities)      SUV39H2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAAGACA
    SUV39H2 Expression
    About this image


    SUV39H2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See SUV39H2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUV39H2

    SOURCE GeneReport for Unigene cluster: Hs.554883
        SABiosciences Custom PCR Arrays for SUV39H2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SUV39H2
    OriGene qSTAR qPCR primer pairs in human, mouse for SUV39H2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SUV39H2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUV39H2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUV39H2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV39H2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SUV39H2 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Suv39h21 , 5 suppressor of variegation 3-9 homolog 2 (Drosophila)1, 5 88.22(n)1
    90.66(a)1
      2 (1.95 cM)5
    647071  NM_022724.41  NP_073561.21 
     34558155 
    chicken
    (Gallus gallus)
    Aves SUV39H21 suppressor of variegation 3-9 homolog 2 (Drosophila) 79.44(n)
    78.61(a)
      426314  NM_001031370.2  NP_001026541.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.192442 Xenopus laevis transcribed sequence with weak similarity more 74.78(n)    BJ634014.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe02c042 Transcribed sequence with moderate similarity to protein more 75.56(n)    57059912 
    fruit fly
    (Drosophila melanogaster)
    Insecta Su(var)3-93 translational initiation translation
    initiation more
    34(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea set-116
    set-126
    (see all 3)
    Protein SET-12
    (see all 3)
    24(a)
    17(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    II(2690472-2694311)
    X(7733339-7736270)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SET26
    Histone methyltransferase with a role in transcrip...
    9(a)
    1 → many
    X(102227-104428)


    ENSEMBL Gene Tree for SUV39H2 (if available)
    TreeFam Gene Tree for SUV39H2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUV39H2 gene
    NSD12  EZH12  ASH1L2  WHSC12  WHSC1L12  SETBP12  SUV39H12  SETD22  
    EHMT12  EHMT22  EZH22  
    10 SIMAP similar genes for SUV39H2 using alignment to 6 protein entries:     SUV92_HUMAN (see all proteins):
    SUV39H1    CBX5    EHMT1    CBX4    EHMT2    EZH2
    FP13812    CBX1    MLL4    DKFZp686C08112

    SUV39H2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SUV39H2
    PGOHUM00000243662 PGOHUM00000241323


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/609 SNPs in SUV39H2 are shown (see all 609)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363444
    A breast cancer sample4--see VAR_0363442 D H mis40--------
    rs1456536591,2
    --14918804(+) GCCGGC/TCATCT 3 -- us2k10--------
    rs1163872461,2
    F--14918837(+) ATGCTA/GCGAAG 3 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1381148831,2
    C--14918869(+) ATATGC/TTCAAT 5 -- us2k10--------
    rs1896097151,2
    --14918892(+) TGCAAC/TACCTA 5 -- us2k10--------
    rs1427054121,2
    --14919089(+) GAACCA/CAGGTT 6 -- us2k10--------
    rs1459998851,2
    --14919100(+) GGACTC/GAGGAA 6 -- us2k10--------
    rs1157079721,2
    F--14919139(+) CAGTGA/GGTAGC 6 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1818613891,2
    --14919191(+) GTAATG/TAATAC 6 -- us2k10--------
    rs1839664921,2
    --14919203(+) GGGGCC/TGGTTA 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for SUV39H2 (14920782 - 14946314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SUV39H2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv997994CNV Deletion20482838
    esv3880CNV Deletion18987735
    esv2733484CNV Deletion23290073
    esv2184273CNV Deletion18987734
    nsv831793CNV Loss17160897
    esv6295CNV Loss19470904
    nsv469720CNV Complex16826518

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SUV39H2
    DNA2.0 Custom Variant and Variant Library Synthesis for SUV39H2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606503    OMIM disorders: --

    3 diseases for SUV39H2:    About MalaCards
    type 1 diabetes    hypoxia    lung cancer


    SUV39H2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SUV39H2
    Human Genome Epidemiology (HuGE) Navigator: SUV39H2 (2 documents)

    Export disorders for SUV39H2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUV39H2 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with SUV39H2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. (PubMed id 11094092)1, 3, 9 O'Carroll D....Jenuwein T. (2000)
    2. Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer. (PubMed id 16774942)1, 4, 9 Yoon K.A....Lee J.S. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells. (PubMed id 14765126)1, 2 Ait-Si-Ali S.... Harel-Bellan A. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    7. Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression. (PubMed id 15107829)1, 2 Frontelo P....Lechleider R.J. (2004)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    9. Genetic examination of SETD7 and SUV39H1/H2 methyltra nsferases and the risk of diabetes complications in patients with type 1 diabet es. (PubMed id 21896933)1 Syreeni A....Groop P.H. (2011)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79723 HGNC: 17287 AceView: SUV39H2 Ensembl:ENSG00000152455 euGenes: HUgn79723
    ECgene: SUV39H2 Kegg: 79723 H-InvDB: SUV39H2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUV39H2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUV39H2 gene:
    Search GeneIP for patents involving SUV39H2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SUV39H2  
     OriGene qPCR primer pairs and template standards for SUV39H2   OriGene Protein Over-expression Lysate for SUV39H2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SUV39H2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SUV39H2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SUV39H2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SUV39H2   OriGene Custom Protein Services for SUV39H2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SUV39H2
     QIAGEN SeqTarget long-range PCR primers for resequencing SUV39H2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUV39H2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUV39H2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUV39H2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUV39H2
     GenScript Custom Purified and Recombinant Proteins Services for SUV39H2 GenScript cDNA clones with any tag delivered in your preferred vector for SUV39H2
     GenScript Custom Assay Services for SUV39H2 GenScript Custom Superior Antibodies Services for SUV39H2
     GenScript Custom overexpressing Cell Line Services for SUV39H2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SUV39H2 promoter
     Search Chromatin IP Primers for SUV39H2
     RT2 qPCR Primer Assay in human, mouse, rat SUV39H2
     Search GNC Networks for SUV39H2
     SABiosciences Custom PCR Arrays for SUV39H2
     Search Tocris compounds for SUV39H2 (SUV92)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SUV39H2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SUV39H2 antibodies
     SUV39H2 proteins
     SUV39H2 lysates
     Antibodies for SUV39H2
     See all of Abcam's Antibodies, Kits and Proteins for SUV39H2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SUV39H2
     Antibodies for SUV39H2
     ELISAs for SUV39H2
     CLIAs for SUV39H2
     Search LifeMap BioReagents cell lines for SUV39H2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV39H2
     SwitchGear 3'UTR luciferase reporter plasmids for SUV39H2
     SwitchGear Promoter luciferase reporter plasmids for SUV39H2
     ThermoFisher Antibody for SUV39H2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUV39H2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SUV39H2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUV39H2
    Customized:
     lentivirus for stable overexpression of SUV39H2
     lentivirus expression plasmids for stable overexpression of SUV39H2
     adenovirus for overexpression of SUV39H2
     LSBio Antibodies in human, mouse, rat for SUV39H2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SUV39H2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4