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SUV39H2 Gene

protein-coding   GIFtS: 63
GCID: GC10P014922

Suppressor Of Variegation 3-9 Homolog 2 (Drosophila)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor Of Variegation 3-9 Homolog 2 (Drosophila)1 2     H3-K9-HMTase 22 3
Histone H3-K9 Methyltransferase 22 3     EC 2.1.1.433 8
Lysine N-Methyltransferase 1B2 3     Histone-Lysine N-Methyltransferase SUV39H22
Su(Var)3-9 Homolog 22 3     Suppressor Of Variegation 3-9 Homolog 23
KMT1B2 3     FLJ234145

External Ids:    HGNC: 172871   Entrez Gene: 797232   Ensembl: ENSG000001524557   OMIM: 6065035   UniProtKB: Q9H5I13   

Export aliases for SUV39H2 gene to outside databases

Previous GC identifers: GC10P014903 GC10P015071 GC10P014924 GC10P014960 GC10P014921 GC10P014831


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SUV39H2 Gene:
SUV39H2 (suppressor of variegation 3-9 homolog 2 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include chromatin binding and histone methyltransferase activity (H3-K9 specific). An important paralog of this gene is NSD1.

UniProtKB/Swiss-Prot: SUV92_HUMAN, Q9H5I1
Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3
'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional
repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in
heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at
pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at
pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many
processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May
participate in regulation of higher-order chromatin organization during spermatogenesis

Gene Wiki entry for SUV39H2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUV39H2 gene promoter:
         Nkx3-1   Sox5   Nkx3-1 v1   POU6F1 (c2)   Evi-1   FOXL1   Nkx3-1 v2   Nkx3-1 v3   MRF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUV39H2 promoter sequence
   Search Chromatin IP Primers for SUV39H2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUV39H2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

SUV39H2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUV39H2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P014922:  view genomic region     (about GC identifiers)

Start:
14,920,782 bp from pter      End:
14,946,314 bp from pter
Size:
25,533 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SUV92_HUMAN, Q9H5I1 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SUV39H2  
Size: 410 amino acids; 46682 Da
Subunit: Interacts with SMAD5
1 PDB 3D structure from and Proteopedia for SUV39H2:
2R3A (3D)    
Secondary accessions: D3DRT4 Q5JSS4 Q5JSS5 Q6I9Y3 Q8ND06
Alternative splicing: 3 isoforms:  Q9H5I1-1   Q9H5I1-2   Q9H5I1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SUV39H2: NX_Q9H5I1

Explore proteomics data for SUV39H2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SUV39H2 (Q9H5I1) (see all 20)
     QIKIPPG  KNHKGMI  TVCKCGA  EYYLVKW 


    See SUV39H2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001180353.1  NP_001180354.1  NP_001180355.1  NP_001180356.1  NP_078946.1  

    ENSEMBL proteins: 
     ENSP00000367582   ENSP00000388968   ENSP00000367576   ENSP00000346997   ENSP00000319208  
     ENSP00000392201   ENSP00000388218   ENSP00000351046  

    SUV39H2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SUV39H2
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    Novus Biologicals SUV39H2 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUV39H2

     
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    SUV39H2 Assay Products:

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    Cloud-Clone Corp. ELISAs for SUV39H2
    Cloud-Clone Corp. CLIAs for SUV39H2
    Search eBioscience for ELISAs for SUV39H2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KMT: Chromatin-modifying enzymes / K-methyltransferases

    Selected InterPro protein domains (see all 8):
     IPR001214 SET_dom
     IPR003616 Post-SET_dom
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9H5I1

    ProtoNet protein and cluster: Q9H5I1

    4 Blocks protein domains:
    IPB000953 Chromo domain
    IPB001214 Nuclear protein SET
    IPB003606 Nuclear protein Zn2+-binding
    IPB003616 SET-related region


    UniProtKB/Swiss-Prot: SUV92_HUMAN, Q9H5I1
    Domain: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains
    are required for methyltransferase activity. The SET domain also participates to stable binding to
    heterochromatin (By similarity)
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. Suvar3-9 subfamily
    Similarity: Contains 1 chromo domain
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 pre-SET domain
    Similarity: Contains 1 SET domain


    Find genes that share domains with SUV39H2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUV92_HUMAN, Q9H5I1
    Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3
    'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional
    repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in
    heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at
    pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at
    pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many
    processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May
    participate in regulation of higher-order chromatin organization during spermatogenesis
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Number (IUBMB): EC 2.1.1.431 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI17474147
    GO:0008168methyltransferase activity ----
    GO:0008270zinc ion binding IEA--
    GO:0008276protein methyltransferase activity ----
         
    Find genes that share ontologies with SUV39H2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SUV39H2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Synthetic lethal with Ras 
     Upregulation of Wnt/beta-caten 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Suv39h2):
     embryogenesis  growth/size/body  mortality/aging  reproductive system  tumorigenesis 

    Find genes that share phenotypes with SUV39H2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUV39H2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SUV39H2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUV39H2
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SUV39H2 (see all 18):
    hsa-miR-30c hsa-miR-496 hsa-miR-30d hsa-miR-548s hsa-miR-3653 hsa-miR-30a hsa-miR-3658 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidSUV39H2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SUV39H2

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    GenScript: all cDNA clones in your preferred vector (see all 5): SUV39H2 (NM_001193427)
    Sino Biological Human cDNA Clone for SUV39H2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUV39H2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUV39H2
    Addgene plasmids for SUV39H2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV39H2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SUV92_HUMAN, Q9H5I1: Nucleus (By similarity). Chromosome, centromere (By similarity). Note=Associates with
    centromeric constitutive heterochromatin (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000785chromatin IDA10949293
    GO:0005634nucleus ----
    GO:0005720nuclear heterochromatin IEA--

    Find genes that share ontologies with SUV39H2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SUV39H2 About    
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Histone modification0.31
    2Lysine degradation
    Lysine degradation


    Find genes that share SuperPaths with SUV39H2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for SUV39H2):
        Lysine degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SUV39H2
    Interactions:

        Search GeneGlobe Interaction Network for SUV39H2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUV39H2 (Q9H5I11, 2, 3 ENSP000003192084) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110815 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111583 I2D: score=3 STRING: ENSP00000357656
    PIK3R1P279862, 3, ENSP000002743354MINT-8112303 I2D: score=3 STRING: ENSP00000274335
    PLCG1P191742, 3, ENSP000002440074MINT-8112819 I2D: score=3 STRING: ENSP00000244007
    CEP70Q8NHQ12, 3MINT-8272454 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006333chromatin assembly or disassembly IMP10949293
    GO:0006338chromatin remodeling IDA10949293
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007140male meiosis IEA--

    Find genes that share ontologies with SUV39H2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUV39H2 (SUV92)

    2 HMDB Compounds for SUV39H2    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SUV39H2 gene (5 alternative transcripts): 
    NM_001193424.1  NM_001193425.1  NM_001193426.1  NM_001193427.1  NM_024670.3  

    Unigene Cluster for SUV39H2:

    Suppressor of variegation 3-9 homolog 2 (Drosophila)
    Hs.554883  [show with all ESTs]
    Unigene Representative Sequence: NM_001193424
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378331(uc021png.1 uc001ing.3 uc001inh.3) ENST00000433779
    ENST00000378325 ENST00000354919 ENST00000313519(uc001ini.3 uc021pnh.1 uc001inj.3)
    ENST00000420416 ENST00000412254 ENST00000358298
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SUV39H2 (see all 18):
    hsa-miR-30c hsa-miR-496 hsa-miR-30d hsa-miR-548s hsa-miR-3653 hsa-miR-30a hsa-miR-3658 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidSUV39H2 3' UTR sequence
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    Addgene plasmids for SUV39H2 
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      QuantiTect SYBR Green Assays in human, mouse, rat SUV39H2
      QuantiFast Probe-based Assays in human, mouse, rat SUV39H2

    Additional mRNA sequence: 

    AK027067.1 AK222565.1 AK225369.1 AL834488.1 BC007754.2 BC029360.1 CR457372.1 NR_034181.1 

    9 DOTS entries:

    DT.95178104  DT.110472  DT.95169804  DT.40119293  DT.100781428  DT.100751441  DT.121264001  DT.92424102 
    DT.100730668 

    Selected AceView cDNA sequences (see all 87):

    AL557161 CR602124 AW518089 CR607132 CA448749 CA426280 AK027067 BM801054 
    BM468558 BX337528 AL834488 AA417340 AI802158 BC029360 CR600204 AA236468 
    BI488686 AI347262 BI543228 BM806112 AA232651 BQ422352 NM_024670 BG574641 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SUV39H2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
    SP1:                    -     -                                 
    SP2:                          -                                 
    SP3:                                                            
    SP4:                    -     -     -                           


    ECgene alternative splicing isoforms for SUV39H2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SUV39H2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAAGACA
    SUV39H2 Expression
    About this image


    SUV39H2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
     
     Bone (Muscoskeletal System)
             Paraxial Mesoderm Cells Branchial Arch 1
    SUV39H2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUV39H2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.554883
        Custom PCR Arrays for SUV39H2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV39H2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SUV39H2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Suv39h21 , 5 suppressor of variegation 3-9 homolog 2 (Drosophila)1, 5 87.82(n)1
    90.12(a)1
      2 (1.95 cM)5
    647071  NM_022724.41  NP_073561.21 
     34558155 
    chicken
    (Gallus gallus)
    Aves SUV39H21 suppressor of variegation 3-9 homolog 2 (Drosophila) 79.44(n)
    78.61(a)
      426314  NM_001031370.2  NP_001026541.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.192442 Xenopus laevis transcribed sequence with weak similarity more 74.78(n)    BJ634014.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe02c042 Transcribed sequence with moderate similarity to protein more 75.56(n)    57059912 
    fruit fly
    (Drosophila melanogaster)
    Insecta Su(var)3-93 translational initiation translation
    initiation more
    34(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea mes-46
    Protein MES-4 (mes-4) mRNA, complete cds
    6(a)
    many ↔ many
    V(13433054-13437545) WBGene00003222
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SET26
    Histone methyltransferase with a role in transcrip...
    6(a)
    1 → many
    X(102227-104428) YJL168C


    ENSEMBL Gene Tree for SUV39H2 (if available)
    TreeFam Gene Tree for SUV39H2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUV39H2 gene
    NSD12  ASH1L2  WHSC12  WHSC1L12  SETBP12  SETDB22  SUV39H12  SETD22  
    EHMT12  EHMT22  SETMAR2  SETDB12  
    10 SIMAP similar genes for SUV39H2 using alignment to 6 protein entries:     SUV92_HUMAN (see all proteins):
    SUV39H1    CBX5    EHMT1    CBX4    EHMT2    EZH2
    FP13812    CBX1    DKFZp686C08112    CBX3

    Find genes that share paralogs with SUV39H2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SUV39H2
    PGOHUM00000243662 PGOHUM00000241323


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SUV39H2 (see all 609)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363444
    A breast cancer sample4--see VAR_0363442 D H mis40--------
    rs1456536591,2
    --14918804(+) GCCGGC/TCATCT 3 -- us2k10--------
    rs1163872461,2
    F--14918837(+) ATGCTA/GCGAAG 3 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1381148831,2
    C--14918869(+) ATATGC/TTCAAT 5 -- us2k10--------
    rs1896097151,2
    --14918892(+) TGCAAC/TACCTA 5 -- us2k10--------
    rs1427054121,2
    --14919089(+) GAACCA/CAGGTT 6 -- us2k10--------
    rs1459998851,2
    --14919100(+) GGACTC/GAGGAA 6 -- us2k10--------
    rs1157079721,2
    F--14919139(+) CAGTGA/GGTAGC 6 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1818613891,2
    --14919191(+) GTAATG/TAATAC 6 -- us2k10--------
    rs1839664921,2
    --14919203(+) GGGGCC/TGGTTA 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for SUV39H2 (14920782 - 14946314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SUV39H2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv997994CNV Deletion20482838
    esv3880CNV Deletion18987735
    esv2733484CNV Deletion23290073
    esv2184273CNV Deletion18987734
    nsv831793CNV Loss17160897
    esv6295CNV Loss19470904
    nsv469720CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUV39H2
    DNA2.0 Custom Variant and Variant Library Synthesis for SUV39H2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606503    OMIM disorders: --


    Find genes that share disorders with SUV39H2           About GenesLikeMe

    Genetic Association Database (GAD): SUV39H2
    Human Genome Epidemiology (HuGE) Navigator: SUV39H2 (2 documents)

    Export disorders for SUV39H2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUV39H2 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with SUV39H2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. (PubMed id 11094092)1, 3, 9 O'Carroll D....Jenuwein T. (Mol. Cell. Biol. 2000)
    2. Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer. (PubMed id 16774942)1, 4, 9 Yoon K.A....Lee J.S. (Carcinogenesis 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells. (PubMed id 14765126)1, 2 Ait-Si-Ali S.... Harel-Bellan A. (EMBO J. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    7. Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression. (PubMed id 15107829)1, 2 Frontelo P....Lechleider R.J. (Oncogene 2004)
    8. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PubMed id 23793025)1 Anttila V.... . (Nat. Genet. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79723 HGNC: 17287 AceView: SUV39H2 Ensembl:ENSG00000152455 euGenes: HUgn79723
    ECgene: SUV39H2 Kegg: 79723 H-InvDB: SUV39H2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SUV39H2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SUV39H2 gene:
    Search GeneIP for patents involving SUV39H2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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