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Aliases for SUV39H2 Gene

Aliases for SUV39H2 Gene

  • Suppressor Of Variegation 3-9 Homolog 2 2 3 4 5
  • Histone H3-K9 Methyltransferase 2 3 4
  • Lysine N-Methyltransferase 1B 3 4
  • Su(Var)3-9 Homolog 2 3 4
  • H3-K9-HMTase 2 3 4
  • EC 2.1.1.43 4 63
  • KMT1B 3 4
  • Suppressor Of Variegation 3-9 Homolog 2 (Drosophila) 2

External Ids for SUV39H2 Gene

Previous GeneCards Identifiers for SUV39H2 Gene

  • GC10P014903
  • GC10P015071
  • GC10P014924
  • GC10P014960
  • GC10P014921
  • GC10P014831
  • GC10P014922

Summaries for SUV39H2 Gene

GeneCards Summary for SUV39H2 Gene

SUV39H2 (Suppressor Of Variegation 3-9 Homolog 2) is a Protein Coding gene. Among its related pathways are Lysine degradation and Chromatin organization. GO annotations related to this gene include chromatin binding and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is EHMT1.

UniProtKB/Swiss-Prot for SUV39H2 Gene

  • Histone methyltransferase that specifically trimethylates Lys-9 of histone H3 using monomethylated H3 Lys-9 as substrate. H3 Lys-9 trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 Lys-9 trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 Lys-9 trimethylation.

Gene Wiki entry for SUV39H2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUV39H2 Gene

Genomics for SUV39H2 Gene

Regulatory Elements for SUV39H2 Gene

Promoters for SUV39H2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUV39H2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUV39H2 Gene

Chromosome:
10
Start:
14,878,783 bp from pter
End:
14,904,315 bp from pter
Size:
25,533 bases
Orientation:
Plus strand

Genomic View for SUV39H2 Gene

Genes around SUV39H2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUV39H2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUV39H2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUV39H2 Gene

Proteins for SUV39H2 Gene

  • Protein details for SUV39H2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5I1-SUV92_HUMAN
    Recommended name:
    Histone-lysine N-methyltransferase SUV39H2
    Protein Accession:
    Q9H5I1
    Secondary Accessions:
    • D3DRT4
    • Q5JSS4
    • Q5JSS5
    • Q6I9Y3
    • Q8ND06

    Protein attributes for SUV39H2 Gene

    Size:
    410 amino acids
    Molecular mass:
    46682 Da
    Quaternary structure:
    • Interacts with SMAD5. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex.

    Three dimensional structures from OCA and Proteopedia for SUV39H2 Gene

    Alternative splice isoforms for SUV39H2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUV39H2 Gene

Proteomics data for SUV39H2 Gene at MOPED

Post-translational modifications for SUV39H2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for SUV39H2 Gene

Gene Families for SUV39H2 Gene

Suggested Antigen Peptide Sequences for SUV39H2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H5I1

UniProtKB/Swiss-Prot:

SUV92_HUMAN :
  • Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin (By similarity).
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
Domain:
  • Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin (By similarity).
  • In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
  • Contains 1 chromo domain.
  • Contains 1 post-SET domain.
  • Contains 1 pre-SET domain.
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
genes like me logo Genes that share domains with SUV39H2: view

Function for SUV39H2 Gene

Molecular function for SUV39H2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
UniProtKB/Swiss-Prot Function:
Histone methyltransferase that specifically trimethylates Lys-9 of histone H3 using monomethylated H3 Lys-9 as substrate. H3 Lys-9 trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 Lys-9 trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 Lys-9 trimethylation.

Enzyme Numbers (IUBMB) for SUV39H2 Gene

Gene Ontology (GO) - Molecular Function for SUV39H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with SUV39H2: view
genes like me logo Genes that share phenotypes with SUV39H2: view

Animal Models for SUV39H2 Gene

MGI Knock Outs for SUV39H2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUV39H2 Gene

Localization for SUV39H2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUV39H2 Gene

Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUV39H2 Gene COMPARTMENTS Subcellular localization image for SUV39H2 gene
Compartment Confidence
nucleus 5
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for SUV39H2 Gene

Pathways & Interactions for SUV39H2 Gene

genes like me logo Genes that share pathways with SUV39H2: view

Pathways by source for SUV39H2 Gene

1 GeneTex pathway for SUV39H2 Gene
1 KEGG pathway for SUV39H2 Gene

Gene Ontology (GO) - Biological Process for SUV39H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 21402781
GO:0006338 chromatin remodeling IDA 10949293
GO:0006351 transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
GO:0036124 histone H3-K9 trimethylation ISS --
genes like me logo Genes that share ontologies with SUV39H2: view

No data available for SIGNOR curated interactions for SUV39H2 Gene

Drugs & Compounds for SUV39H2 Gene

(2) Drugs for SUV39H2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with SUV39H2: view

Transcripts for SUV39H2 Gene

Unigene Clusters for SUV39H2 Gene

Suppressor of variegation 3-9 homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUV39H2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3:
SP4: - - -

Relevant External Links for SUV39H2 Gene

GeneLoc Exon Structure for
SUV39H2
ECgene alternative splicing isoforms for
SUV39H2

Expression for SUV39H2 Gene

mRNA expression in normal human tissues for SUV39H2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUV39H2 Gene

This gene is overexpressed in Testis (x5.7).

Protein differential expression in normal tissues from HIPED for SUV39H2 Gene

This gene is overexpressed in Testis (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUV39H2 Gene



SOURCE GeneReport for Unigene cluster for SUV39H2 Gene Hs.554883

genes like me logo Genes that share expression patterns with SUV39H2: view

Protein tissue co-expression partners for SUV39H2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SUV39H2 Gene

Orthologs for SUV39H2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUV39H2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUV39H2 35
  • 94.24 (n)
  • 96.74 (a)
SUV39H2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUV39H2 35
  • 95.15 (n)
  • 98.25 (a)
-- 36
  • 90 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Suv39h2 35
  • 87.82 (n)
  • 90.12 (a)
Suv39h2 16
Suv39h2 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUV39H2 35
  • 99.51 (n)
  • 99.76 (a)
SUV39H2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Suv39h2 35
  • 88.67 (n)
  • 89.98 (a)
oppossum
(Monodelphis domestica)
Mammalia SUV39H2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUV39H2 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUV39H2 35
  • 79.44 (n)
  • 78.61 (a)
SUV39H2 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.423 35
suv39h2 35
  • 72.35 (n)
  • 76.05 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19244 35
zebrafish
(Danio rerio)
Actinopterygii wufe02c04 35
fruit fly
(Drosophila melanogaster)
Insecta Su(var)3-9 37
  • 34 (a)
Su(var)3-9 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mes-4 36
  • 6 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SET2 36
  • 6 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12074 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
ManyToMany
CSA.9082 36
  • 47 (a)
ManyToMany
Species with no ortholog for SUV39H2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUV39H2 Gene

ENSEMBL:
Gene Tree for SUV39H2 (if available)
TreeFam:
Gene Tree for SUV39H2 (if available)

Paralogs for SUV39H2 Gene

(10) SIMAP similar genes for SUV39H2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SUV39H2 Gene

genes like me logo Genes that share paralogs with SUV39H2: view

Variants for SUV39H2 Gene

Sequence variations from dbSNP and Humsavar for SUV39H2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_036344 A breast cancer sample
rs1141548 -- 14,901,748(+) atcac(G/T)tgaac intron-variant
rs1141553 -- 14,901,773(+) ctaca(A/G)tgagc intron-variant
rs2400103 -- 14,877,419(+) ACTGC(A/T)GAACA upstream-variant-2KB
rs3740112 -- 14,897,016(+) AATAA(C/T)AAAAC intron-variant, nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SUV39H2 Gene

Variant ID Type Subtype PubMed ID
nsv469720 CNV Complex 16826518
nsv831793 CNV Loss 17160897
esv2184273 CNV Deletion 18987734
esv3880 CNV Deletion 18987735
esv2733484 CNV Deletion 23290073
esv997994 CNV Deletion 20482838
esv6295 CNV Loss 19470904

Variation tolerance for SUV39H2 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUV39H2 Gene

HapMap Linkage Disequilibrium report
SUV39H2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUV39H2 Gene

Disorders for SUV39H2 Gene

Relevant External Links for SUV39H2

Genetic Association Database (GAD)
SUV39H2
Human Genome Epidemiology (HuGE) Navigator
SUV39H2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUV39H2

No disorders were found for SUV39H2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUV39H2 Gene

Publications for SUV39H2 Gene

  1. Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. (PMID: 11094092) O'Carroll D. … Jenuwein T. (Mol. Cell. Biol. 2000) 2 3 23 67
  2. Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer. (PMID: 16774942) Yoon K.A. … Lee J.S. (Carcinogenesis 2006) 3 23
  3. Activity and specificity of the human SUV39H2 protein lysine methyltransferase. (PMID: 25459750) Schuhmacher M.K. … Jeltsch A. (Biochim. Biophys. Acta 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SUV39H2 Gene

Sources for SUV39H2 Gene

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