Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SUV39H1 Gene

Aliases for SUV39H1 Gene

  • Suppressor Of Variegation 3-9 Homolog 1 (Drosophila) 2 3
  • Position-Effect Variegation 3-9 Homolog 3 4
  • Histone H3-K9 Methyltransferase 1 3 4
  • Lysine N-Methyltransferase 1A 3 4
  • Su(Var)3-9 Homolog 1 3 4
  • H3-K9-HMTase 1 3 4
  • EC 2.1.1.43 4 64
  • SUV39H 3 4
  • KMT1A 3 4
  • Histone-Lysine N-Methyltransferase, H3 Lysine-9 Specific 1 3
  • Suppressor Of Variegation 3-9 (Drosophila) Homolog 1 2
  • Histone-Lysine N-Methyltransferase SUV39H1 3
  • Suppressor Of Variegation 3-9 Homolog 1 4
  • MG44 3

External Ids for SUV39H1 Gene

Previous Symbols for SUV39H1 Gene

  • SUV39H

Summaries for SUV39H1 Gene

Entrez Gene Summary for SUV39H1 Gene

  • This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for SUV39H1 Gene

SUV39H1 (Suppressor Of Variegation 3-9 Homolog 1 (Drosophila)) is a Protein Coding gene. Among its related pathways are RB in Cancer and Chromatin Regulation / Acetylation. GO annotations related to this gene include chromatin binding and histone-lysine N-methyltransferase activity. An important paralog of this gene is EHMT1.

UniProtKB/Swiss-Prot for SUV39H1 Gene

  • Histone methyltransferase that specifically trimethylates Lys-9 of histone H3 using monomethylated H3 Lys-9 as substrate. Also weakly methylates histone H1 (in vitro). H3 Lys-9 trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 Lys-9 trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 Lys-9 trimethylation.

Gene Wiki entry for SUV39H1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUV39H1 Gene

Genomics for SUV39H1 Gene

Genomic Location for SUV39H1 Gene

Start:
48,695,554 bp from pter
End:
48,709,016 bp from pter
Size:
13,463 bases
Orientation:
Plus strand

Genomic View for SUV39H1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUV39H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUV39H1 Gene

Regulatory Elements for SUV39H1 Gene

Proteins for SUV39H1 Gene

  • Protein details for SUV39H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43463-SUV91_HUMAN
    Recommended name:
    Histone-lysine N-methyltransferase SUV39H1
    Protein Accession:
    O43463
    Secondary Accessions:
    • B2R6E8
    • B4DST0
    • Q53G60
    • Q6FHK6

    Protein attributes for SUV39H1 Gene

    Size:
    412 amino acids
    Molecular mass:
    47907 Da
    Quaternary structure:
    • Interacts with H3 and H4 histones. Interacts with GFI1B, DNMT3B, CBX1, CBX4, CCAR2, MBD1, RUNX1, RUNX3, MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through the N-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. In case of infection, interacts with HTLV-1 Tax protein, leading to abrogate Tax transactivation of HTLV-1 LTR. Interacts (via SET domain) with MECOM; enhances MECOM transcriptional repression activity. Interacts with LMNA; the interaction increases stability of SUV39H1. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex.

    Three dimensional structures from OCA and Proteopedia for SUV39H1 Gene

    Alternative splice isoforms for SUV39H1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUV39H1 Gene

Proteomics data for SUV39H1 Gene at MOPED

Post-translational modifications for SUV39H1 Gene

  • Acetylated at Lys-266, leading to inhibition of enzyme activity. SIRT1-mediated deacetylation relieves this inhibition.
  • Phosphorylated on serine residues, and to a lesser degree, on threonine residues. The phosphorylated form is stabilized by SBF1 and is less active in its transcriptional repressor function.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys6, Lys121, and Lys138

Other Protein References for SUV39H1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SUV39H1 Gene

Gene Families for SUV39H1 Gene

HGNC:
  • KMT :Chromatin-modifying enzymes / K-methyltransferases

UniProtKB/Swiss-Prot:

SUV91_HUMAN
Domain:
  • Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin.:
    • O43463
  • In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.:
    • O43463
  • Contains 1 chromo domain.:
    • O43463
  • Contains 1 post-SET domain.:
    • O43463
  • Contains 1 pre-SET domain.:
    • O43463
  • Contains 1 SET domain.:
    • O43463
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.:
    • O43463
genes like me logo Genes that share domains with SUV39H1: view

Function for SUV39H1 Gene

Molecular function for SUV39H1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by S-adenosyl-L-homocysteine. Negatively regulated by CCAR2.
UniProtKB/Swiss-Prot Function: Histone methyltransferase that specifically trimethylates Lys-9 of histone H3 using monomethylated H3 Lys-9 as substrate. Also weakly methylates histone H1 (in vitro). H3 Lys-9 trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 Lys-9 trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 Lys-9 trimethylation.

Enzyme Numbers (IUBMB) for SUV39H1 Gene

Gene Ontology (GO) - Molecular Function for SUV39H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0003682 chromatin binding TAS 10202156
GO:0005515 protein binding IPI 10949293
GO:0008270 zinc ion binding IEA --
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IDA 10949293
genes like me logo Genes that share ontologies with SUV39H1: view
genes like me logo Genes that share phenotypes with SUV39H1: view

miRNA for SUV39H1 Gene

miRTarBase miRNAs that target SUV39H1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SUV39H1 Gene

Localization for SUV39H1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUV39H1 Gene

Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUV39H1 Gene COMPARTMENTS Subcellular localization image for SUV39H1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SUV39H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000792 heterochromatin IDA 18004385
GO:0000794 condensed nuclear chromosome TAS 10202156
GO:0005634 nucleus IDA 18004385
GO:0005652 nuclear lamina IEA --
genes like me logo Genes that share ontologies with SUV39H1: view

Pathways for SUV39H1 Gene

genes like me logo Genes that share pathways with SUV39H1: view

Pathways by source for SUV39H1 Gene

1 Cell Signaling Technology pathway for SUV39H1 Gene
2 BioSystems pathways for SUV39H1 Gene
1 KEGG pathway for SUV39H1 Gene

Gene Ontology (GO) - Biological Process for SUV39H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 21402781
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006364 rRNA processing IEA --
genes like me logo Genes that share ontologies with SUV39H1: view

Compounds for SUV39H1 Gene

(15) ApexBio Compounds for SUV39H1 Gene

Compound Action Cas Number
3-Deazaneplanocin,DZNep Blocks EZH2 activity and trimethylation of lysine 27 on histone H3 in vitro. [102052-95-9]
AZ505 potent and highly selective inhibitor of the oncogenic protein SMYD2. [1035227-43-0]
BIX 01294 BIX-01294 is a small molecule inhibitor of G9a and GLP. [935693-62-2]
Chaetocin Histone methyltransferase SUV39H1 inhibitor [28097-03-2]
Entacapone Entacapone inhibits catechol-O-methyltransferase(COMT) [130929-57-6]
EPZ004777 potent, selective DOT1L inhibitor [1338466-77-5]
EPZ005687 potent inhibitor of EZH2 [1396772-26-1]
EPZ5676 potent inhibitor of DOT1L histone methyltransferase [1380288-87-8]
EPZ-6438 potent and bio-available inhibitor of EZH2 [1403254-99-8 ]
SGC 0946 highly potent and selective DOT1 Lmethyltransferase inhibitor
UNC 0224 Potent inhibitor of G9a histone lysine methyltransferase [1197196-48-7]
UNC 0631 potent G9a inhibitor [1320288-19-4]
UNC 0646 Potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP [1320288-17-2]
UNC0321 potent and selective G9a inhibitor [1238673-32-9]
UNC0638 Selective inhibitor of G9a and GLP histone lysine methyltransferases (IC50 values are < 15 nM and 19 nM for G9a and GLP respectively, and > 10000 nM for a range of other histone methyltransferases). [1255580-76-7]

(2) HMDB Compounds for SUV39H1 Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0

(1) Novoseek inferred chemical compound relationships for SUV39H1 Gene

Compound -log(P) Hits PubMed IDs
cytosine 30.1 1
genes like me logo Genes that share compounds with SUV39H1: view

Transcripts for SUV39H1 Gene

Unigene Clusters for SUV39H1 Gene

Suppressor of variegation 3-9 homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUV39H1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for SUV39H1 Gene

GeneLoc Exon Structure for
SUV39H1
ECgene alternative splicing isoforms for
SUV39H1

Expression for SUV39H1 Gene

mRNA expression in normal human tissues for SUV39H1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUV39H1 Gene

SOURCE GeneReport for Unigene cluster for SUV39H1 Gene Hs.522639

genes like me logo Genes that share expressions with SUV39H1: view

Orthologs for SUV39H1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUV39H1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUV39H1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUV39H1 36
  • 93.37 (n)
  • 98.54 (a)
SUV39H1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUV39H1 36
  • 94.42 (n)
  • 98.3 (a)
SUV39H1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Suv39h1 36
  • 87.38 (n)
  • 94.42 (a)
Suv39h1 16
Suv39h1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUV39H1 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Suv39h1 36
  • 88.43 (n)
  • 94.9 (a)
chicken
(Gallus gallus)
Aves SUV39H1 36
  • 76.08 (n)
  • 78.25 (a)
SUV39H1 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUV39H1 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12013 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6972 36
zebrafish
(Danio rerio)
Actinopterygii suv39h1a 37
  • 63 (a)
OneToMany
suv39h1b 36
  • 67.16 (n)
  • 70.05 (a)
suv39h1b 37
  • 68 (a)
OneToMany
wufb18a10 36
fruit fly
(Drosophila melanogaster)
Insecta Su(var)3-9 37
  • 26 (a)
OneToMany
Su(var)3-9 38
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea mes-4 37
  • 7 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SET2 37
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 64 (a)
ManyToMany
CSA.9082 37
  • 46 (a)
ManyToMany
Species with no ortholog for SUV39H1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUV39H1 Gene

ENSEMBL:
Gene Tree for SUV39H1 (if available)
TreeFam:
Gene Tree for SUV39H1 (if available)

Paralogs for SUV39H1 Gene

Selected SIMAP similar genes for SUV39H1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SUV39H1: view

Variants for SUV39H1 Gene

Sequence variations from dbSNP and Humsavar for SUV39H1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3373 -- 48,708,904(-) GGGGG(C/T)CGGCG utr-variant-3-prime
rs183520 -- 48,698,357(-) tagtt(C/T)tagga intron-variant
rs3761543 -- 48,696,246(+) AGGGA(A/G)TCGCC intron-variant, upstream-variant-2KB
rs11798830 -- 48,702,684(+) GCAGC(C/G)TCAGA intron-variant
rs12556257 -- 48,694,671(+) GAATG(A/T)TTCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SUV39H1 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680

Relevant External Links for SUV39H1 Gene

HapMap Linkage Disequilibrium report
SUV39H1
Locus Specific Mutation Databases (LSDB)
SUV39H1

Disorders for SUV39H1 Gene

(2) Novoseek inferred disease relationships for SUV39H1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 34.9 1
tumors 0 1
genes like me logo Genes that share disorders with SUV39H1: view

No data available for UniProtKB/Swiss-Prot for SUV39H1 Gene

Publications for SUV39H1 Gene

  1. Rb targets histone H3 methylation and HP1 to promoters. (PMID: 11484059) Nielsen S.J. … Kouzarides T. (Nature 2001) 3 4 23
  2. Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. (PMID: 12711603) Fujita N. … Nakao M. (J. Biol. Chem. 2003) 3 4 23
  3. Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression. (PMID: 15107829) Frontelo P. … Lechleider R.J. (Oncogene 2004) 3 4 23
  4. A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain. (PMID: 16103223) Krouwels I.M. … Dirks R.W. (J. Cell Biol. 2005) 3 4 23
  5. Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin. (PMID: 16688220) Vassen L. … Moeroey T. (EMBO J. 2006) 3 4 23

Products for SUV39H1 Gene

Sources for SUV39H1 Gene

Back to Top

Content