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SUV39H1 Gene

protein-coding   GIFtS: 64
GCID: GC0XP048554

Suppressor Of Variegation 3-9 Homolog 1 (Drosophila)

(Previous name: suppressor of variegation 3-9 (Drosophila) homolog 1)
(Previous symbol: SUV39H)
  See SUV39H1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor Of Variegation 3-9 Homolog 1 (Drosophila)1 2     Su(Var)3-9 Homolog 12 3
SUV39H1 2 3     EC 2.1.1.433 8
Histone H3-K9 Methyltransferase 12 3     Suppressor Of Variegation 3-9 (Drosophila) Homolog 11
Lysine N-Methyltransferase 1A2 3     MG442
Position-Effect Variegation 3-9 Homolog2 3     Histone-Lysine N-Methyltransferase SUV39H12
KMT1A2 3     Histone-Lysine N-Methyltransferase, H3 Lysine-9 Specific 12
H3-K9-HMTase 12 3     Suppressor Of Variegation 3-9 Homolog 13

External Ids:    HGNC: 114791   Entrez Gene: 68392   Ensembl: ENSG000001019457   OMIM: 3002545   UniProtKB: O434633   

Export aliases for SUV39H1 gene to outside databases

Previous GC identifers: GC0XP047357 GC0XP046815 GC0XP047601 GC0XP048311 GC0XP048439 GC0XP046217


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SUV39H1 Gene:
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET
domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which
results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and
may cause chromosome instability. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Aug 2013)

GeneCards Summary for SUV39H1 Gene:
SUV39H1 (suppressor of variegation 3-9 homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with SUV39H1 include idiopathic pulmonary fibrosis. GO annotations related to this gene include chromatin binding and histone-lysine N-methyltransferase activity. An important paralog of this gene is NSD1.

UniProtKB/Swiss-Prot: SUV91_HUMAN, O43463
Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3
'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a
specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to
methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the
establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is
also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its
interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation,
regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the
PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of
telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates
silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes.
The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of
NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at
'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus

Gene Wiki entry for SUV39H1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUV39H1 gene promoter:
         CREB   PPAR-alpha   PPAR-gamma1   p53   deltaCREB   MyoD   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUV39H1 promoter sequence
   Search Chromatin IP Primers for SUV39H1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUV39H1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

SUV39H1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUV39H1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP048554:  view genomic region     (about GC identifiers)

Start:
48,553,945 bp from pter      End:
48,567,407 bp from pter
Size:
13,463 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SUV91_HUMAN, O43463 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SUV39H1  
Size: 412 amino acids; 47907 Da
Subunit: Interacts with H3 and H4 histones. Interacts with GFI1B, DNMT3B, CBX1, CBX4, CCAR2, MBD1, RUNX1, RUNX3,
MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through the
N-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and RBBP7.
Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. In case of infection, interacts with HTLV-1
Tax protein, leading to abrogate Tax transactivation of HTLV-1 LTR. Interacts (via SET domain) with MECOM;
enhances MECOM transcriptional repression activity (By similarity). Interacts with LMNA; the interaction
increases stability of SUV39H1
Developmental stage: Accumulates during mitosis at centromeres during prometaphase, but dissociates from the
centromere at the meta- to anaphase transition
1 PDB 3D structure from and Proteopedia for SUV39H1:
3MTS (3D)    
Secondary accessions: B2R6E8 Q53G60 Q6FHK6

Explore the universe of human proteins at neXtProt for SUV39H1: NX_O43463

Explore proteomics data for SUV39H1 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residues, and to a lesser degree, on threonine residues. The phosphorylated form is
    stabilized by SBF1 and is less active in its transcriptional repressor function1
  • Acetylated at Lys-266, leading to inhibition of enzyme activity. SIRT1-mediated deacetylation relieves this
    inhibition1
  • Ubiquitination2 at Lys6, Lys121, Lys138
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SUV39H1 (O43463) (see all 21)
     VQKAKQR  GGCCPGA  CGTESCR  EYYLVKW 


    See SUV39H1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269095.1  NP_003164.1  

    ENSEMBL proteins: 
     ENSP00000365877   ENSP00000337976   ENSP00000410686  
    Reactome Protein details: O43463

    SUV39H1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SUV39H1
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    Novus Biologicals SUV39H1 Proteins
    Novus Biologicals SUV39H1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUV39H1

     
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    SUV39H1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SUV39H1
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    Novus Biologicals SUV39H1 Antibodies
    Abcam antibodies for SUV39H1
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    ThermoFisher Antibody for SUV39H1
    LSBio Antibodies in human, mouse, rat for SUV39H1

    SUV39H1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for SUV39H1
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    Search eBioscience for ELISAs for SUV39H1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KMT: Chromatin-modifying enzymes / K-methyltransferases

    Selected InterPro protein domains (see all 9):
     IPR001214 SET_dom
     IPR003616 Post-SET_dom
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR003606 Pre-SET_Zn-bd_sub

    Graphical View of Domain Structure for InterPro Entry O43463

    ProtoNet protein and cluster: O43463

    4 Blocks protein domains:
    IPB000953 Chromo domain
    IPB001214 Nuclear protein SET
    IPB003606 Nuclear protein Zn2+-binding
    IPB003616 SET-related region


    UniProtKB/Swiss-Prot: SUV91_HUMAN, O43463
    Domain: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains
    are required for methyltransferase activity. The SET domain also participates to stable binding to
    heterochromatin
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. Suvar3-9 subfamily
    Similarity: Contains 1 chromo domain
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 pre-SET domain
    Similarity: Contains 1 SET domain


    Find genes that share domains with SUV39H1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUV91_HUMAN, O43463
    Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3
    'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a
    specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to
    methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the
    establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is
    also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its
    interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation,
    regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the
    PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of
    telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates
    silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes.
    The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of
    NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at
    'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]
    Enzyme regulation: Inhibited by S-adenosyl-L-homocysteine. Negatively regulated by CCAR2

         Enzyme Number (IUBMB): EC 2.1.1.431 2

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding TAS10202156
    GO:0005515protein binding IPI10949293
    GO:0008168methyltransferase activity ----
    GO:0008270zinc ion binding IEA--
    GO:0008757S-adenosylmethionine-dependent methyltransferase activity IDA10949293
         
    Find genes that share ontologies with SUV39H1           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Suv39h1):
     embryogenesis  growth/size/body  hematopoietic system  immune system  mortality/aging 
     reproductive system  tumorigenesis 

    Find genes that share phenotypes with SUV39H1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUV39H1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SUV39H1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUV39H1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUV39H1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SUV39H1:
    hsa-mir-615-3p (MIRT040438), hsa-mir-98-5p (MIRT027407), hsa-mir-331-3p (MIRT043442)

    Block miRNA regulation of human, mouse, rat SUV39H1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUV39H1 (see all 52):
    hsa-miR-642a hsa-miR-520e hsa-miR-302d hsa-miR-218-1* hsa-let-7a-2* hsa-miR-301a hsa-miR-486-3p hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidSUV39H1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SUV39H1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SUV39H1 (NM_003173)
    Sino Biological Human cDNA Clone for SUV39H1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUV39H1
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    Addgene plasmids for SUV39H1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV39H1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SUV91_HUMAN, O43463: Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Note=Associates with
    centromeric constitutive heterochromatin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000792heterochromatin IDA18004385
    GO:0000794condensed nuclear chromosome TAS10202156
    GO:0005634nucleus IDA18004385
    GO:0005652nuclear lamina IEA--

    Find genes that share ontologies with SUV39H1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SUV39H1 About    
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Histone modification0.31
    2Regulation of retinoblastoma protein
    Regulation of retinoblastoma protein
    3RB in Cancer
    RB in Cancer
    4Lysine degradation
    Lysine degradation
    5Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with SUV39H1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SUV39H1
        Chromatin Regulation / Acetylation

    2 BioSystems Pathways for SUV39H1
        RB in Cancer
    Regulation of retinoblastoma protein


    1 Reactome Pathway for SUV39H1
        SIRT1 negatively regulates rRNA Expression


    1 Kegg Pathway  (Kegg details for SUV39H1):
        Lysine degradation

        Pathway & Disease-focused RT2 Profiler PCR Array including SUV39H1: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SUV39H1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUV39H1 (O434631, 2, 3 ENSP000003658774) via UniProtKB, MINT, STRING, and/or I2D (see all 167)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=3 STRING: ENSP00000350275
    HIST1H3HP684313, ENSP000003581604I2D: score=3 STRING: ENSP00000358160
    HIST1H3BP684313I2D: score=3 
    HIST1H3CP684313I2D: score=3 
    HIST1H3DP684313I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000183chromatin silencing at rDNA IDA18485871
    GO:0006325chromatin organization TAS10949293
    GO:0006351transcription, DNA-templated IEA--
    GO:0006364rRNA processing IEA--
    GO:0007049cell cycle IEA--

    Find genes that share ontologies with SUV39H1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for SUV39H1 (see all 15)     About this table
    CompoundAction CAS #
    3-Deazaneplanocin,DZNepBlocks EZH2 activity and trimethylation of lysine 27 on histone H3 in vitro[102052-95-9]
    AZ505potent and highly selective inhibitor of the oncogenic protein SMYD2[1035227-43-0]
    BIX 01294BIX-01294 is a small molecule inhibitor of G9a and GLP[935693-62-2]
    ChaetocinHistone methyltransferase SUV39H1 inhibitor[28097-03-2]
    EntacaponeEntacapone inhibits catechol-O-methyltransferase(COMT)[130929-57-6]
    EPZ-6438potent and bio-available inhibitor of EZH2[1403254-99-8 ]
    EPZ004777potent, selective DOT1L inhibitor[1338466-77-5]
    EPZ005687potent inhibitor of EZH2[1396772-26-1]
    EPZ5676potent inhibitor of DOT1L histone methyltransferase[1380288-87-8]
    SGC 0946highly potent and selective DOT1 Lmethyltransferase inhibitor--

    Browse Tocris compounds for SUV39H1 (SUV91)

    2 HMDB Compounds for SUV39H1    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    1 Novoseek inferred chemical compound relationship for SUV39H1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytosine 30.1 1 16980612 (1)



    Find genes that share compounds with SUV39H1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SUV39H1 gene (2 alternative transcripts): 
    NM_001282166.1  NM_003173.3  

    Unigene Cluster for SUV39H1:

    Suppressor of variegation 3-9 homolog 1 (Drosophila)
    Hs.522639  [show with all ESTs]
    Unigene Representative Sequence: L08238
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376687(uc011mmf.2 uc004dkn.3 uc011mmg.2) ENST00000482260
    ENST00000462786 ENST00000337852 ENST00000453214
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SUV39H1 (see all 52):
    hsa-miR-642a hsa-miR-520e hsa-miR-302d hsa-miR-218-1* hsa-let-7a-2* hsa-miR-301a hsa-miR-486-3p hsa-miR-764
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    GenScript: all cDNA clones in your preferred vector: SUV39H1 (NM_003173)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUV39H1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUV39H1
    Addgene plasmids for SUV39H1 
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      QuantiTect SYBR Green Assays in human, mouse, rat SUV39H1
      QuantiFast Probe-based Assays in human, mouse, rat SUV39H1

    Additional mRNA sequence: 

    AF019968.1 AF075109.1 AK223071.1 AK297566.1 AK298233.1 AK299900.1 AK312547.1 BC006238.2 
    CR541746.1 L08238.1 

    7 DOTS entries:

    DT.113687  DT.100784920  DT.91755662  DT.91878649  DT.95168417  DT.75102138  DT.97845218 

    Selected AceView cDNA sequences (see all 139):

    CB215427 BG257891 BQ061063 BQ053468 AW327567 BG180484 BM907099 H62092 
    CR609770 BQ054568 BU175919 BM924514 BE018667 BM786422 C01417 BX094167 
    AL583349 CR595067 BF343714 CR541746 BQ044982 BQ679992 H61188 CA488621 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SUV39H1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:        -                       -                                 
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for SUV39H1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SUV39H1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTGAATCT
    SUV39H1 Expression
    About this image


    SUV39H1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Lymph (Hematopoietic System)
    SUV39H1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUV39H1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522639
        Pathway & Disease-focused RT2 Profiler PCR Array including SUV39H1: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SUV39H1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Suv39h11 , 5 suppressor of variegation 3-9 homolog 1 (Drosophila)1, 5 87.38(n)1
    94.42(a)1
      X (3.64 cM)5
    209371  NM_011514.21  NP_035644.11 
     80611715 
    chicken
    (Gallus gallus)
    Aves SUV39H11 suppressor of variegation 3-9 homolog 1 (Drosophila) 76.08(n)
    78.25(a)
      100857640  XM_003643897.2  XP_003643945.2 
    lizard
    (Anolis carolinensis)
    Reptilia SUV39H16
    suppressor of variegation 3-9 homolog 1 (Drosophil...
    81(a)
    1 ↔ 1
    2(69508238-69518799)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120132 Xenopus laevis transcribed sequence with moderate similarity more 77.43(n)    BU913965.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb18a102 Danio rerio cDNA clone IMAGE6033994 76.32(n)    BC052225.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Su(var)3-93 translational initiation translation
    initiation more
    36(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea mes-46
    Protein MES-4 (mes-4) mRNA, complete cds
    7(a)
    many ↔ many
    V(13433054-13437545) WBGene00003222
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SET26
    Histone methyltransferase with a role in transcrip...
    7(a)
    1 → many
    X(102227-104428) YJL168C


    ENSEMBL Gene Tree for SUV39H1 (if available)
    TreeFam Gene Tree for SUV39H1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUV39H1 gene
    NSD12  ASH1L2  WHSC12  WHSC1L12  SUV39H22  SETBP12  SETDB22  SETD22  
    EHMT12  EHMT22  SETMAR2  SETDB12  
    4 SIMAP similar genes for SUV39H1 using alignment to 3 protein entries:     SUV91_HUMAN (see all proteins):
    SUV39H2    FP13812    CBX5    MG44

    Find genes that share paralogs with SUV39H1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SUV39H1 (see all 143)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850010721,2
    --48472885(+) AACTGC/TCTAAG 1 -- us2k10--------
    rs1899294041,2
    C--48473330(+) TTTGGC/TTGACT 1 -- us2k10--------
    rs1421235191,2
    C--48473387(+) ACAGCA/GCAGTT 1 -- us2k10--------
    rs1820425931,2
    --48473506(+) ATGGCC/TCGTGG 1 -- us2k10--------
    rs1870790441,2
    --48473804(+) CTGACA/GATGTG 1 -- us2k10--------
    rs1512902551,2
    --48473901(+) CGGACC/TGTCTG 1 -- us2k10--------
    rs726190281,2
    C--48474148(+) CAGGGC/TTGTAT 1 -- us2k10--------
    rs1893339311,2
    --48474283(+) GTGGAC/GAGGAG 1 -- us2k10--------
    rs171482491,2
    F--48474293(+) GGACTG/CATTGA 1 -- us2k11Minor allele frequency- C:0.02EA 200
    rs1807003761,2
    --48474327(+) ATGGTC/TTTAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SUV39H1 (48553945 - 48567407 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SUV39H1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528292CNV Gain19592680
    esv32909CNV Gain+Loss17666407

    Locus Specific Mutation Databases (LSDB): SUV39H1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUV39H1
    DNA2.0 Custom Variant and Variant Library Synthesis for SUV39H1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300254    OMIM disorders: --

    1 disease for SUV39H1:    
    About MalaCards
    idiopathic pulmonary fibrosis


    Find genes that share disorders with SUV39H1           About GenesLikeMe

    2 Novoseek inferred disease relationships for SUV39H1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 34.9 1 11484059 (1)
    tumors 0 1 19881540 (1)


    Export disorders for SUV39H1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUV39H1 gene, integrated from 10 sources (see all 127):
    (articles sorted by number of sources associating them with SUV39H1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. (PubMed id 10202156)1, 2, 3 Aagaard L....Jenuwein T. (EMBO J. 1999)
    2. SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR. (PubMed id 16409643)1, 2, 9 Kamoi K.... Watanabe T. (Retrovirology 2006)
    3. A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain. (PubMed id 16103223)1, 2, 9 Krouwels I.M.... Dirks R.W. (J. Cell Biol. 2005)
    4. Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation. (PubMed id 16858404)1, 2, 9 Mal A.K. (EMBO J. 2006)
    5. Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis. (PubMed id 16519522)1, 2, 9 Chin H.G.... Pradhan S. (Biochemistry 2006)
    6. SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. (PubMed id 18004385)1, 2, 9 Vaquero A....Reinberg D. (Nature 2007)
    7. Rb targets histone H3 methylation and HP1 to promoters. (PubMed id 11484059)1, 2, 9 Nielsen S.J....Kouzarides T. (Nature 2001)
    8. Inhibition of SUV39H1 methyltransferase activity by DBC1. (PubMed id 19218236)1, 2, 9 Li Z.... Chen J. (J. Biol. Chem. 2009)
    9. Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression. (PubMed id 15107829)1, 2, 9 Frontelo P....Lechleider R.J. (Oncogene 2004)
    10. Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. (PubMed id 12711603)1, 2, 9 Fujita N.... Nakao M. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6839 HGNC: 11479 AceView: SUV39H1 Ensembl:ENSG00000101945 euGenes: HUgn6839
    ECgene: SUV39H1 Kegg: 6839 H-InvDB: SUV39H1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SUV39H1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SUV39H1 gene:
    Search GeneIP for patents involving SUV39H1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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