SUV39H1 Gene
protein-coding GIFtS: 62
GCID: GC0XP048554
|
|
suppressor of variegation 3-9 homolog 1 (Drosophila)(Previous name: suppressor of variegation 3-9 (Drosophila) homolog 1 )
(Previous symbol: SUV39H)
| |
Aliases
for SUV39H1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Suppressor Of Variegation 3-9 Homolog 1 (Drosophila)1 2 | | Su(Var)3-9 Homolog 12 3 | | KMT1A1 2 3 | | EC 2.1.1.433 8 | | SUV39H1 2 3 | | Suppressor Of Variegation 3-9 (Drosophila) Homolog 11 | | Histone H3-K9 Methyltransferase 12 3 | | MG442 | | Lysine N-Methyltransferase 1A2 3 | | Histone-Lysine N-Methyltransferase SUV39H12 | | Position-Effect Variegation 3-9 Homolog2 3 | | Histone-Lysine N-Methyltransferase, H3 Lysine-9 Specific 12 | | H3-K9-HMTase 12 3 | | Suppressor Of Variegation 3-9 Homolog 13 |
Export aliases for SUV39H1 gene to outside databasesPrevious GC identifers: GC0XP047357 GC0XP046815 GC0XP047601 GC0XP048311 GC0XP048439 GC0XP046217 |
Summaries
for SUV39H1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SUV39H1:
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain anda C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histonemethyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization,chromosome segregation, and mitotic progression. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SUV91_HUMAN, O43463Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specifictag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylatedhistones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment ofconstitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to directDNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involvedin many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch forexiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-inducedrepression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC(energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellularenergy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy statusof cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin inthe rDNA locus
Gene Wiki entry for SUV39H1
|
Genomic Views
for SUV39H1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SUV39H1 gene promoter:
CREB PPAR-alpha PPAR-gamma1 p53 deltaCREB MyoD PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SUV39H1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUV39H1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23SUV39H1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP048554: view genomic region
(about GC identifiers)
Start:
|
48,553,945 bp from pter |
End:
|
48,567,407 bp from pter |
Size:
|
13,463 bases |
Orientation:
|
plus strand |
|
Proteins
for SUV39H1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SUV91_HUMAN, O43463 (See
protein sequence)Recommended Name: Histone-lysine N-methyltransferase SUV39H1 Size: 412 amino acids; 47907 Da
Subunit: Interacts with H3 and H4 histones. Interacts with GFI1B, DNMT3B, CBX1, CBX4, KIAA1967/DBC1, MBD1, RUNX1,RUNX3, MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through theN-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and RBBP7.Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. In case of infection, interacts with HTLV-1 Taxprotein, leading to abrogate Tax transactivation of HTLV-1 LTR. Interacts (via SET domain) with MECOM; enhances MECOMtranscriptional repression activity (By similarity)
Subcellular location: Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin
Developmental stage: Accumulates during mitosis at centromeres during prometaphase, but dissociates from the centromereat the meta- to anaphase transition
1 PDB 3D structure from  and Proteopedia  for SUV39H1:3MTS (3D)
Secondary accessions: B2R6E8 Q53G60 Q6FHK6Explore the universe of human proteins at neXtProt for SUV39H1: NX_O43463
Post-translational modifications:
Phosphorylated on serine residues, and to a lesser degree, on threonine residues. The phosphorylated form is stabilizedby SBF1 and is less active in its transcriptional repressor function1
Acetylated at Lys-266, leading to inhibition of enzyme activity. SIRT1-mediated deacetylation relieves this inhibition1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43463
4/21 DME Specific Peptides for SUV39H1 (O43463) (see all 21)
SUV39H1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003164.1
ENSEMBL proteins: ENSP00000365877 ENSP00000337976 ENSP00000410686
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
SUV39H1 for ontologies About GeneDecksing
SUV39H1 Antibody Products:
Assay Products for SUV39H1: |
Protein
Domains /
Families
for SUV39H1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SUV39H1 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry O43463ProtoNet protein and cluster: O43463 4 Blocks protein families: IPB000953 Chromo domain IPB001214 Nuclear protein SET IPB003606 Nuclear protein Zn2+-binding IPB003616 SET-related region
UniProtKB/Swiss-Prot: SUV91_HUMAN, O43463Domain: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains arerequired for methyltransferase activity. The SET domain also participates to stable binding to heterochromatinSimilarity: Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamilySimilarity: Contains 1 chromo domainSimilarity: Contains 1 post-SET domainSimilarity: Contains 1 pre-SET domainSimilarity: Contains 1 SET domain |
Function
for SUV39H1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SUV91_HUMAN, O43463Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specifictag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylatedhistones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment ofconstitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to directDNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involvedin many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch forexiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-inducedrepression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC(energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellularenergy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy statusof cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin inthe rDNA locusCatalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +N(6)-methyl-L-lysine-[histone]Enzyme regulation: Inhibited by S-adenosyl-L-homocysteine. Negatively regulated by KIAA1967/DBC1Enzyme Number (IUBMB): EC 2.1.1.431 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUV39H1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUV39H1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SUV39H1 (NM_003173) | |  | Sino Biological Human cDNA Clone for SUV39H1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SUV39H1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUV39H1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV39H1 |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
SUV39H1 for ontologies About GeneDecksing
Animal Models:
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Suv39h1):
SUV39H1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SUV39H1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chromatin Regulation / Acetylation | | | 2 | Regulation of retinoblastoma protein | | | 3 | Lysine degradation | | | 4 | Signal transduction Activin A signaling regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for SUV39H1
1 
Cell Signaling Technology (CST) Pathway for SUV39H1
1  BioSystems Pathway for SUV39H1
1 
Kegg Pathway (Kegg details for SUV39H1):
SUV39H1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SUV39H1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/93 Interacting proteins for SUV39H1 (O434631, 2, 3 ENSP000003658774) via UniProtKB, MINT, STRING, and/or I2D (see all 93)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
SUV39H1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SUV39H1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SUV39H1 for compounds About GeneDecksing
 Browse Tocris compounds for SUV39H1
2 HMDB Compounds for SUV39H1 About this table
1 Novoseek chemical compound relationship for SUV39H1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cytosine |
30.1 |
1 |
16980612 (1) |
Search CenterWatch for drugs/clinical trials and news about SUV39H1 / SUV91
|
Transcripts
for SUV39H1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SUV39H1 gene: NM_003173.2 Unigene Cluster for SUV39H1: Suppressor of variegation 3-9 homolog 1 (Drosophila) Hs.522639 [show with all ESTs]Unigene Representative Sequence: L082385 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376687(uc011mmf.2 uc004dkn.3 uc011mmg.2) ENST00000482260
ENST00000462786 ENST00000337852 ENST00000453214
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUV39H1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUV39H1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SUV39H1 (NM_003173) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SUV39H1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUV39H1 |
Additional cDNA sequence: AF019968.1 AF075109.1 AK223071.1 AK297566.1 AK298233.1 AK299900.1 AK312547.1 BC006238.2 CR541746.1 L08238.1 7 DOTS entries: DT.113687 DT.100784920 DT.91755662 DT.91878649 DT.95168417 DT.75102138 DT.97845218 24/139 AceView cDNA sequences (see all 139): BQ053468 BU509377 BG180484 AF075109 BQ929666 H62092 BM976757 BE018667 BQ061063 AI672598 BC006238 BM907099 BU175919 BQ882021 BQ218816 BU540530 BQ054568 AW327506 BQ044982 CA488621 AA496685 AL572380 BU147353 BQ448128
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SUV39H1 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | - | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SUV39H1
|
Expression
for SUV39H1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SUV39H1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTGAATCT
About this image
See SUV39H1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SUV39H1
SOURCE GeneReport for Unigene cluster: Hs.522639
SABiosciences Expression via Pathway-Focused PCR Array including SUV39H1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUV39H1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SUV39H1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUV39H1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUV39H1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV39H1 |
Orthologs
for SUV39H1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SUV39H1 gene from 8/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008576401 |
histone-lysine N-methyltransferase SUV39H1-like |
76.08(n)
78.25(a) |
|
100857640 XM_003643897.1 XP_003643945.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SUV39H16 |
-- |
78(a) |
1 ↔ 1 |
2(69512267-69518799) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.120132 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.43(n) |
|
BU913965.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb18a102 |
Danio rerio cDNA clone IMAGE6033994 |
76.32(n) |
|
BC052225.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Su(var)3-93 |
translational initiation translation
initiation more |
36(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
set-256set-116 |
SET (trithorax/polycomb) domain containing family ...SET (trithorax/polycomb) domain containing family ... |
8(a)20(a) |
possible orthologpossible ortholog |
III(13283791-13292984) II(2690477-2694316) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SDG216SDG226(see all 16) |
histone-lysine N-methyltransferase, H3 lysine-9 sp...putative histone-lysine N-methyltransferase, H3 ly...(see all 16) |
9(a)9(a)(see all 16) |
possible orthologpossible ortholog(see all 16) |
2(10529690-10531957) 4(7824034-7827004) |
rice
(Oryza sativa) |
Liliopsida |
----(see all 17) |
histone-lysine N-methyltransferase, H3 lysine-9 sp...histone-lysine N-methyltransferase, putative, expr...(see all 17) |
9(a)7(a)(see all 17) |
possible orthologpossible ortholog(see all 17) |
11(22692343-22698129) 9(11868806-11873416) |
ENSEMBL Gene Tree for SUV39H1 (if available)
TreeFam Gene Tree for SUV39H1 (if available) |
Paralogs
for SUV39H1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SUV39H1 gene
- NSD12 EZH12 WHSC12 SUV39H22 WHSC1L12 SETDB22 SETD22 EHMT12
- EHMT22 EZH22 SETDB12
4 SIMAP similar genes for SUV39H1 using alignment to 3 protein entries: SUV91_HUMAN (see all proteins):SUV39H2 FP13812 CBX5 MG44
SUV39H1 for paralogs About GeneDecksing
|
Genomic Variants
for SUV39H1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SUV39H1 (48553945 - 48567407 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SUV39H1
1 CNV: 7789
Locus Specific Mutation Databases (LSDB): SUV39H1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SUV39H1 |
|
Disorders
/ Diseases
for SUV39H1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SUV39H1 for disorders About GeneDecksing
OMIM gene information: 300254
OMIM disorders: --
17  diseases for SUV39H1: About MalaCardswiskott-aldrich syndrome idiopathic pulmonary fibrosis pulmonary fibrosis kaposi's sarcoma
retinoblastoma fibrosis hyperglycemia sarcoma
homocysteine hepatocellular carcinoma colorectal cancer breast cancer
hypoxia thyroiditis carcinoma leukemia
neuronitis
2 Novoseek disease relationships for SUV39H1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinoblastoma |
34.9 |
1 |
11484059 (1) |
| tumors |
0 |
1 |
19881540 (1) |
Export disorders for SUV39H1 gene to outside databases
|
Publications
for SUV39H1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SUV39H1 gene, integrated from 9 sources (see all 109):
(articles sorted by number of sources associating them with SUV39H1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. (PubMed id 10202156)1, 2, 3 Aagaard L....Jenuwein T. (1999)
- SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR. (PubMed id 16409643)1, 2, 9 Kamoi K.... Watanabe T. (2006)
- A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain. (PubMed id 16103223)1, 2, 9 Krouwels I.M.... Dirks R.W. (2005)
- Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation. (PubMed id 16858404)1, 2, 9 Mal A.K. (2006)
- Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis. (PubMed id 16519522)1, 2, 9 Chin H.G.... Pradhan S. (2006)
- SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. (PubMed id 18004385)1, 2, 9 Vaquero A....Reinberg D. (2007)
- Rb targets histone H3 methylation and HP1 to promoters. (PubMed id 11484059)1, 2, 9 Nielsen S.J....Kouzarides T. (2001)
- Inhibition of SUV39H1 methyltransferase activity by DBC1. (PubMed id 19218236)1, 2, 9 Li Z.... Chen J. (2009)
- Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression. (PubMed id 15107829)1, 2, 9 Frontelo P....Lechleider R.J. (2004)
- Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. (PubMed id 12711603)1, 2, 9 Fujita N.... Nakao M. (2003)
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External Searches for SUV39H1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing SUV39H1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SUV39H1 gene
(According to HUGE)
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Specialized Databases showing SUV39H1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for SUV39H1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SUV39H1 gene:
Search GeneIP for patents involving SUV39H1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SUV39H1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for SUV39H1 | | OriGene shRNA RFP for SUV39H1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUV39H1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUV39H1 | | | OriGene Protein Over-expression Lysate for SUV39H1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SUV39H1 | | OriGene 3'-UTR Clone for SUV39H1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUV39H1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUV39H1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SUV39H1 | | OriGene Custom Protein Services for SUV39H1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SUV39H1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SUV39H1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUV39H1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUV39H1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUV39H1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUV39H1 |
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| | | | Search Tocris compounds for SUV39H1 |
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 | | | SUV39H1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV39H1 |
|  |  |  | | | | ThermoFisher Antibodies for SUV39H1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUV39H1 |
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