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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUV39H1 Gene

protein-coding   GIFtS: 62
GCID: GC0XP048554

Suppressor Of Variegation 3-9 Homolog 1 (Drosophila)

(Previous name: suppressor of variegation 3-9 (Drosophila) homolog 1)
(Previous symbol: SUV39H)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppressor Of Variegation 3-9 Homolog 1 (Drosophila)1 2     Su(Var)3-9 Homolog 12 3
SUV39H1 2 3     EC 2.1.1.433 8
Histone H3-K9 Methyltransferase 12 3     Suppressor Of Variegation 3-9 (Drosophila) Homolog 11
Lysine N-Methyltransferase 1A2 3     MG442
Position-Effect Variegation 3-9 Homolog2 3     Histone-Lysine N-Methyltransferase SUV39H12
KMT1A2 3     Histone-Lysine N-Methyltransferase, H3 Lysine-9 Specific 12
H3-K9-HMTase 12 3     Suppressor Of Variegation 3-9 Homolog 13

External Ids:    HGNC: 114791   Entrez Gene: 68392   Ensembl: ENSG000001019457   OMIM: 3002545   UniProtKB: O434633   

Export aliases for SUV39H1 gene to outside databases

Previous GC identifers: GC0XP047357 GC0XP046815 GC0XP047601 GC0XP048311 GC0XP048439 GC0XP046217


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUV39H1 Gene:
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET
domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which
results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and
may cause chromosome instability. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Aug 2013)

GeneCards Summary for SUV39H1 Gene: 
SUV39H1 (suppressor of variegation 3-9 homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with SUV39H1 include idiopathic pulmonary fibrosis, and pulmonary fibrosis, and among its related super-pathways are Signal transduction Activin A signaling regulation. GO annotations related to this gene include chromatin binding and histone-lysine N-methyltransferase activity. An important paralog of this gene is NSD1.

UniProtKB/Swiss-Prot: SUV91_HUMAN, O43463
Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3
'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a
specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to
methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the
establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is
also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its
interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation,
regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the
PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of
telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates
silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes.
The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of
NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at
'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus

Gene Wiki entry for SUV39H1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_079573.4  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUV39H1 gene promoter:
         CREB   PPAR-alpha   PPAR-gamma1   p53   deltaCREB   MyoD   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUV39H1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SUV39H1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUV39H1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

SUV39H1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUV39H1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP048554:  view genomic region     (about GC identifiers)

Start:
48,553,945 bp from pter      End:
48,567,407 bp from pter
Size:
13,463 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SUV91_HUMAN, O43463 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase SUV39H1  
Size: 412 amino acids; 47907 Da
Subunit: Interacts with H3 and H4 histones. Interacts with GFI1B, DNMT3B, CBX1, CBX4, KIAA1967/DBC1, MBD1, RUNX1,
RUNX3, MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through
the N-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and
RBBP7. Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. In case of infection, interacts with
HTLV-1 Tax protein, leading to abrogate Tax transactivation of HTLV-1 LTR. Interacts (via SET domain) with MECOM;
enhances MECOM transcriptional repression activity (By similarity)
Subcellular location: Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive
heterochromatin
Developmental stage: Accumulates during mitosis at centromeres during prometaphase, but dissociates from the
centromere at the meta- to anaphase transition
1 PDB 3D structure from and Proteopedia for SUV39H1:
3MTS (3D)    
Secondary accessions: B2R6E8 Q53G60 Q6FHK6

Explore the universe of human proteins at neXtProt for SUV39H1: NX_O43463

Explore proteomics data for SUV39H1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on serine residues, and to a lesser degree, on threonine residues. The phosphorylated form is
    stabilized by SBF1 and is less active in its transcriptional repressor function
  • UniProtKB: Acetylated at Lys-266, leading to inhibition of enzyme activity. SIRT1-mediated deacetylation relieves this
    inhibition
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43463

  • 4/21 DME Specific Peptides for SUV39H1 (O43463) (see all 21)
     VQKAKQR  GGCCPGA  CGTESCR  EYYLVKW 

    SUV39H1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SUV39H1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001269095.1  NP_003164.1  

    ENSEMBL proteins: 
     ENSP00000365877   ENSP00000337976   ENSP00000410686  

    Human Recombinant Protein Products for SUV39H1: 
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    OriGene Protein Over-expression Lysate for SUV39H1
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    Novus Biologicals SUV39H1 Proteins
    Novus Biologicals SUV39H1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUV39H1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000792heterochromatin IDA18004385
    GO:0000794condensed nuclear chromosome TAS10202156
    GO:0005634nucleus IDA18004385
    GO:0005677chromatin silencing complex IDA18485871

    SUV39H1 for ontologies           About GeneDecksing



    SUV39H1 Antibody Products: 
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    Abcam antibodies for SUV39H1
    Cloud-Clone Corp. Antibodies for SUV39H1 
    ThermoFisher Antibody for SUV39H1
    LSBio Antibodies in human, mouse, rat for SUV39H1 

    Assay Products for SUV39H1: 
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    Cloud-Clone Corp. ELISAs for SUV39H1 
    Cloud-Clone Corp. CLIAs for SUV39H1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KMT: Chromatin-modifying enzymes / K-methyltransferases

    5/9 InterPro protein domains (see all 9):
     IPR001214 SET_dom
     IPR003616 Post-SET_dom
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR003606 Pre-SET_Zn-bd_sub

    Graphical View of Domain Structure for InterPro Entry O43463

    ProtoNet protein and cluster: O43463

    4 Blocks protein domains:
    IPB000953 Chromo domain
    IPB001214 Nuclear protein SET
    IPB003606 Nuclear protein Zn2+-binding
    IPB003616 SET-related region


    UniProtKB/Swiss-Prot: SUV91_HUMAN, O43463
    Domain: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains
    are required for methyltransferase activity. The SET domain also participates to stable binding to
    heterochromatin
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. Suvar3-9 subfamily
    Similarity: Contains 1 chromo domain
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 pre-SET domain
    Similarity: Contains 1 SET domain


    SUV39H1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUV91_HUMAN, O43463
    Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3
    'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a
    specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to
    methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the
    establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is
    also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its
    interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation,
    regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the
    PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of
    telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates
    silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes.
    The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of
    NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at
    'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]
    Enzyme regulation: Inhibited by S-adenosyl-L-homocysteine. Negatively regulated by KIAA1967/DBC1

         Enzyme Number (IUBMB): EC 2.1.1.431 2

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding TAS10202156
    GO:0005515protein binding IPI10949293
    GO:0008168methyltransferase activity ----
    GO:0008270zinc ion binding IEA--
    GO:0008757S-adenosylmethionine-dependent methyltransferase activity IDA10949293
         
    SUV39H1 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Suv39h1):
     embryogenesis  growth/size  immune system  mortality/aging  reproductive system 
     tumorigenesis 

    SUV39H1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SUV39H1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUV39H1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUV39H1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUV39H1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUV39H1
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate SUV39H1 (see all 52):
    hsa-miR-642a hsa-miR-520e hsa-miR-302d hsa-miR-218-1* hsa-let-7a-2* hsa-miR-301a hsa-miR-486-3p hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidSUV39H1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUV39H1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SUV39H1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Histone modification0.31
    2Regulation of retinoblastoma protein
    Regulation of retinoblastoma protein
    3Lysine degradation
    Lysine degradation
    4Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SUV39H1
        Histone modification


    1 Cell Signaling Technology (CST) Pathway for SUV39H1
        Chromatin Regulation / Acetylation

    1 BioSystems Pathway for SUV39H1
        Regulation of retinoblastoma protein



    1         Kegg Pathway  (Kegg details for SUV39H1):
        Lysine degradation


    SUV39H1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SUV39H1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/93 Interacting proteins for SUV39H1 (O434631, 2, 3 ENSP000003658774) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=3 STRING: ENSP00000350275
    HIST1H3HP684313, ENSP000003581604I2D: score=3 STRING: ENSP00000358160
    HIST1H3BP684313I2D: score=3 
    HIST1H3CP684313I2D: score=3 
    HIST1H3DP684313I2D: score=3 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000183chromatin silencing at rDNA IDA18485871
    GO:0006325chromatin organization TAS10949293
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006364rRNA processing IEA--
    GO:0007049cell cycle IEA--

    SUV39H1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SUV39H1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUV39H1 (SUV91)

    2 HMDB Compounds for SUV39H1    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    1 Novoseek inferred chemical compound relationship for SUV39H1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytosine 30.1 1 16980612 (1)

    Search CenterWatch for drugs/clinical trials and news about SUV39H1 / SUV91

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUV39H1 gene (2 alternative transcripts): 
    NM_001282166.1  NM_003173.3  

    Unigene Cluster for SUV39H1:

    Suppressor of variegation 3-9 homolog 1 (Drosophila)
    Hs.522639  [show with all ESTs]
    Unigene Representative Sequence: L08238
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376687(uc011mmf.2 uc004dkn.3 uc011mmg.2) ENST00000482260
    ENST00000462786 ENST00000337852 ENST00000453214
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUV39H1
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    Additional mRNA sequence: 

    AF019968.1 AF075109.1 AK223071.1 AK297566.1 AK298233.1 AK299900.1 AK312547.1 BC006238.2 
    CR541746.1 L08238.1 

    7 DOTS entries:

    DT.113687  DT.100784920  DT.91755662  DT.91878649  DT.95168417  DT.75102138  DT.97845218 

    24/139 AceView cDNA sequences (see all 139):

    BG108433 CR541746 BQ054568 AW327506 CD616491 BM833873 BQ929666 AL583349 
    AW204826 BQ053468 BQ218206 BQ218816 BE018667 BM976757 C01417 H61188 
    CR609770 H62092 BG180484 BQ061063 AA496685 BQ882021 BM924514 AL572380 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SUV39H1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:        -                       -                                 
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for SUV39H1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUV39H1 expression in normal human tissues (normalized intensities)      SUV39H1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTGAATCT
    SUV39H1 Expression
    About this image


    SUV39H1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             mandibular prominence tissue e10.0   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Cartilage (Muscoskeletal System)
             skeleton/cranium   
     
     Head Mesenchyme (Muscoskeletal System)
             mandibular prominence tissue e10.0   

    See SUV39H1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUV39H1

    SOURCE GeneReport for Unigene cluster: Hs.522639
        SABiosciences Expression via Pathway-Focused PCR Array including SUV39H1: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SUV39H1 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Suv39h11 , 5 suppressor of variegation 3-9 homolog 1 (Drosophila)1, 5 88.11(n)1
    95.39(a)1
      X (3.64 cM)5
    209371  NM_011514.21  NP_035644.11 
     80611715 
    chicken
    (Gallus gallus)
    Aves LOC1008576401 histone-lysine N-methyltransferase SUV39H1-like 76.08(n)
    78.25(a)
      100857640  XM_003643897.1  XP_003643945.1 
    lizard
    (Anolis carolinensis)
    Reptilia SUV39H16
    suppressor of variegation 3-9 homolog 1 (Drosophil...
    79(a)
    1 ↔ 1
    2(69508238-69518799)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120132 Xenopus laevis transcribed sequence with moderate similarity more 77.43(n)    BU913965.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb18a102 Danio rerio cDNA clone IMAGE6033994 76.32(n)    BC052225.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Su(var)3-93 translational initiation translation
    initiation more
    36(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea set-116
    set-126
    (see all 3)
    Protein SET-12
    (see all 3)
    26(a)
    18(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    II(2690472-2694311)
    X(7733339-7736270)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SET26
    Histone methyltransferase with a role in transcrip...
    9(a)
    1 → many
    X(102227-104428)


    ENSEMBL Gene Tree for SUV39H1 (if available)
    TreeFam Gene Tree for SUV39H1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUV39H1 gene
    NSD12  EZH12  ASH1L2  WHSC12  WHSC1L12  SUV39H22  SETBP12  SETD22  
    EHMT12  EHMT22  EZH22  
    4 SIMAP similar genes for SUV39H1 using alignment to 3 protein entries:     SUV91_HUMAN (see all proteins):
    SUV39H2    FP13812    CBX5    MG44

    SUV39H1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/143 SNPs in SUV39H1 are shown (see all 143)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850010721,2
    --48472885(+) AACTGC/TCTAAG 1 -- us2k10--------
    rs1899294041,2
    C--48473330(+) TTTGGC/TTGACT 1 -- us2k10--------
    rs1421235191,2
    C--48473387(+) ACAGCA/GCAGTT 1 -- us2k10--------
    rs1820425931,2
    --48473506(+) ATGGCC/TCGTGG 1 -- us2k10--------
    rs1870790441,2
    --48473804(+) CTGACA/GATGTG 1 -- us2k10--------
    rs1512902551,2
    --48473901(+) CGGACC/TGTCTG 1 -- us2k10--------
    rs726190281,2
    C--48474148(+) CAGGGC/TTGTAT 1 -- us2k10--------
    rs1893339311,2
    --48474283(+) GTGGAC/GAGGAG 1 -- us2k10--------
    rs171482491,2
    F--48474293(+) GGACTG/CATTGA 1 -- us2k11Minor allele frequency- C:0.02EA 200
    rs1807003761,2
    --48474327(+) ATGGTC/TTTAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SUV39H1 (48553945 - 48567407 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SUV39H1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528292CNV Gain19592680
    esv32909CNV Gain+Loss17666407


    Locus Specific Mutation Databases (LSDB): SUV39H1
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SUV39H1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300254    OMIM disorders: --

    20/21 diseases for SUV39H1 (see all 21):    About MalaCards
    idiopathic pulmonary fibrosis    pulmonary fibrosis    retinoblastoma    wiskott-aldrich syndrome
    kaposi's sarcoma    hyperglycemia    prostate cancer, progression of    hypoxia
    type 1 diabetes    sarcoma    hepatocellular carcinoma    colorectal cancer
    thyroiditis    pancreatic cancer    breast cancer    lung cancer
    prostate cancer    neuronitis    pancreatitis    leukemia


    SUV39H1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for SUV39H1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 34.9 1 11484059 (1)
    tumors 0 1 19881540 (1)


    Export disorders for SUV39H1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUV39H1 gene, integrated from 9 sources (see all 127):
    (articles sorted by number of sources associating them with SUV39H1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. (PubMed id 10202156)1, 2, 3 Aagaard L....Jenuwein T. (1999)
    2. SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR. (PubMed id 16409643)1, 2, 9 Kamoi K.... Watanabe T. (2006)
    3. A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain. (PubMed id 16103223)1, 2, 9 Krouwels I.M.... Dirks R.W. (2005)
    4. Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation. (PubMed id 16858404)1, 2, 9 Mal A.K. (2006)
    5. Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis. (PubMed id 16519522)1, 2, 9 Chin H.G.... Pradhan S. (2006)
    6. SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. (PubMed id 18004385)1, 2, 9 Vaquero A....Reinberg D. (2007)
    7. Rb targets histone H3 methylation and HP1 to promoters. (PubMed id 11484059)1, 2, 9 Nielsen S.J....Kouzarides T. (2001)
    8. Inhibition of SUV39H1 methyltransferase activity by DBC1. (PubMed id 19218236)1, 2, 9 Li Z.... Chen J. (2009)
    9. Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression. (PubMed id 15107829)1, 2, 9 Frontelo P....Lechleider R.J. (2004)
    10. Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. (PubMed id 12711603)1, 2, 9 Fujita N.... Nakao M. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6839 HGNC: 11479 AceView: SUV39H1 Ensembl:ENSG00000101945 euGenes: HUgn6839
    ECgene: SUV39H1 Kegg: 6839 H-InvDB: SUV39H1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUV39H1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUV39H1 gene:
    Search GeneIP for patents involving SUV39H1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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