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Aliases for SUSD6 Gene

Aliases for SUSD6 Gene

  • Sushi Domain Containing 6 2 3
  • KIAA0247 2 3 4
  • Drug-Activated Gene Overexpressed Protein 3 4
  • Sushi Domain-Containing Protein 6 3
  • DRAGO 4

External Ids for SUSD6 Gene

Previous Symbols for SUSD6 Gene

  • KIAA0247

Summaries for SUSD6 Gene

GeneCards Summary for SUSD6 Gene

SUSD6 (Sushi Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is SUSD4.

UniProtKB/Swiss-Prot for SUSD6 Gene

  • May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUSD6 Gene

Genomics for SUSD6 Gene

Genomic Location for SUSD6 Gene

Start:
69,611,593 bp from pter
End:
69,715,144 bp from pter
Size:
103,552 bases
Orientation:
Plus strand

Genomic View for SUSD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUSD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUSD6 Gene

No data available for Regulatory Elements for SUSD6 Gene

Proteins for SUSD6 Gene

  • Protein details for SUSD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92537-SUSD6_HUMAN
    Recommended name:
    Sushi domain-containing protein 6
    Protein Accession:
    Q92537
    Secondary Accessions:

    Protein attributes for SUSD6 Gene

    Size:
    303 amino acids
    Molecular mass:
    32090 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13378.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SUSD6 Gene

Proteomics data for SUSD6 Gene at MOPED

Post-translational modifications for SUSD6 Gene

No Post-translational modifications

Other Protein References for SUSD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SUSD6 Gene

Domains for SUSD6 Gene

Protein Domains for SUSD6 Gene

UniProtKB/Swiss-Prot:

SUSD6_HUMAN
Domain:
  • Contains 1 Sushi (CCP/SCR) domain.:
    • Q92537
genes like me logo Genes that share domains with SUSD6: view

No data available for Gene Families for SUSD6 Gene

Function for SUSD6 Gene

Molecular function for SUSD6 Gene

UniProtKB/Swiss-Prot Function: May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated by chemotherapeutic DNA-damaging agents and by p53/TP53 and/or by p73/TP73 in response to cytotoxic insults (PubMed:24652652). Up-regulated by lipopolysaccharide (LPS) in monocytic THP1 cells (PubMed:20236627). Up-regulated in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium.

Gene Ontology (GO) - Molecular Function for SUSD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SUSD6: view
genes like me logo Genes that share phenotypes with SUSD6: view

miRNA for SUSD6 Gene

miRTarBase miRNAs that target SUSD6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SUSD6 Gene

Localization for SUSD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUSD6 Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for SUSD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SUSD6: view

Pathways for SUSD6 Gene

SuperPathways for SUSD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUSD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 24652652
GO:0008150 biological_process --
GO:0008219 cell death IDA 24652652
genes like me logo Genes that share ontologies with SUSD6: view

No data available for Pathways by source for SUSD6 Gene

Transcripts for SUSD6 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SUSD6 Gene

No ASD Table

Relevant External Links for SUSD6 Gene

GeneLoc Exon Structure for
SUSD6
ECgene alternative splicing isoforms for
SUSD6

Expression for SUSD6 Gene

mRNA expression in normal human tissues for SUSD6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SUSD6 Gene

genes like me logo Genes that share expressions with SUSD6: view

Orthologs for SUSD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUSD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0247 36
  • 99.45 (n)
  • 99.01 (a)
KIAA0247 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0247 36
  • 90.78 (n)
  • 92.67 (a)
KIAA0247 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0247 36
  • 91.09 (n)
  • 92.41 (a)
KIAA0247 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4933426M11Rik 36
  • 87.97 (n)
  • 89.4 (a)
4933426M11Rik 16
4933426M11Rik 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA0247 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 71 (a)
OneToMany
-- 37
  • 40 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC678893 36
  • 88.34 (n)
  • 90.1 (a)
chicken
(Gallus gallus)
Aves KIAA0247 36
  • 73.78 (n)
  • 74.67 (a)
KIAA0247 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA0247 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0247 36
  • 65.19 (n)
  • 65.65 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11364 36
si:dkey-11e23.5 36
  • 60.34 (n)
  • 61.66 (a)
si:dkey-11e23.5 37
  • 42 (a)
OneToOne
Species with no ortholog for SUSD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUSD6 Gene

ENSEMBL:
Gene Tree for SUSD6 (if available)
TreeFam:
Gene Tree for SUSD6 (if available)

Paralogs for SUSD6 Gene

Paralogs for SUSD6 Gene

genes like me logo Genes that share paralogs with SUSD6: view

Variants for SUSD6 Gene

Sequence variations from dbSNP and Humsavar for SUSD6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs731659 -- 69,711,209(+) GGCCC(C/T)GCCTT utr-variant-3-prime
rs762049 -- 69,631,637(+) ATAAT(A/G)ATTCT intron-variant
rs762050 -- 69,634,779(+) TATTT(C/T)TGGTA intron-variant
rs867900 -- 69,692,428(+) ctcta(C/G)tactt intron-variant
rs875424 -- 69,684,678(+) AGCCC(C/T)GTGAA intron-variant

Relevant External Links for SUSD6 Gene

HapMap Linkage Disequilibrium report
SUSD6

No data available for Structural Variations from Database of Genomic Variants (DGV) for SUSD6 Gene

Disorders for SUSD6 Gene

No disorders were found for SUSD6 Gene.

No data available for UniProtKB/Swiss-Prot for SUSD6 Gene

Publications for SUSD6 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Characterization of SVEP1, KIAA, and SRPX2 in an in vitro cell culture model of endotoxemia. (PMID: 20236627) Schwanzer-Pfeiffer D. … Falkenhagen D. (Cell. Immunol. 2010) 3 4
  4. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]. (PMID: 24652652) Polato F. … Broggini M. (J. Natl. Cancer Inst. 2014) 3 4
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SUSD6 Gene

Sources for SUSD6 Gene

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