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Aliases for SUSD6 Gene

Aliases for SUSD6 Gene

  • Sushi Domain Containing 6 2 3 5
  • KIAA0247 2 3 4
  • Drug-Activated Gene Overexpressed Protein 3 4
  • DRAGO 3 4

External Ids for SUSD6 Gene

Previous HGNC Symbols for SUSD6 Gene

  • KIAA0247

Summaries for SUSD6 Gene

GeneCards Summary for SUSD6 Gene

SUSD6 (Sushi Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is SUSD4.

UniProtKB/Swiss-Prot for SUSD6 Gene

  • May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUSD6 Gene

Genomics for SUSD6 Gene

Regulatory Elements for SUSD6 Gene

Enhancers for SUSD6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SUSD6 on UCSC Golden Path with GeneCards custom track

Promoters for SUSD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUSD6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUSD6 Gene

Chromosome:
14
Start:
69,611,593 bp from pter
End:
69,715,144 bp from pter
Size:
103,552 bases
Orientation:
Plus strand

Genomic View for SUSD6 Gene

Genes around SUSD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUSD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUSD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUSD6 Gene

Proteins for SUSD6 Gene

  • Protein details for SUSD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92537-SUSD6_HUMAN
    Recommended name:
    Sushi domain-containing protein 6
    Protein Accession:
    Q92537

    Protein attributes for SUSD6 Gene

    Size:
    303 amino acids
    Molecular mass:
    32090 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13378.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SUSD6 Gene

Proteomics data for SUSD6 Gene at MOPED

Post-translational modifications for SUSD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SUSD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SUSD6 Gene

Domains & Families for SUSD6 Gene

Gene Families for SUSD6 Gene

Protein Domains for SUSD6 Gene

Graphical View of Domain Structure for InterPro Entry

Q92537

UniProtKB/Swiss-Prot:

SUSD6_HUMAN :
  • Contains 1 Sushi (CCP/SCR) domain.
Domain:
  • Contains 1 Sushi (CCP/SCR) domain.
genes like me logo Genes that share domains with SUSD6: view

No data available for Suggested Antigen Peptide Sequences for SUSD6 Gene

Function for SUSD6 Gene

Molecular function for SUSD6 Gene

UniProtKB/Swiss-Prot Function:
May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by chemotherapeutic DNA-damaging agents and by p53/TP53 and/or by p73/TP73 in response to cytotoxic insults (PubMed:24652652). Up-regulated by lipopolysaccharide (LPS) in monocytic THP1 cells (PubMed:20236627). Up-regulated in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium.
genes like me logo Genes that share phenotypes with SUSD6: view

Animal Models for SUSD6 Gene

MGI Knock Outs for SUSD6:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUSD6 Gene

Localization for SUSD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUSD6 Gene

Membrane; Single-pass type I membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SUSD6 Gene

Pathways & Interactions for SUSD6 Gene

SuperPathways for SUSD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUSD6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SUSD6 Gene

Drugs & Compounds for SUSD6 Gene

No Compound Related Data Available

Transcripts for SUSD6 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SUSD6 Gene

No ASD Table

Relevant External Links for SUSD6 Gene

GeneLoc Exon Structure for
SUSD6
ECgene alternative splicing isoforms for
SUSD6

Expression for SUSD6 Gene

mRNA expression in normal human tissues for SUSD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SUSD6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUSD6 Gene



genes like me logo Genes that share expression patterns with SUSD6: view

Protein tissue co-expression partners for SUSD6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SUSD6 Gene

Orthologs for SUSD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUSD6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA0247 35
  • 90.78 (n)
  • 92.67 (a)
KIAA0247 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4933426M11Rik 35
  • 87.97 (n)
  • 89.4 (a)
Susd6 16
4933426M11Rik 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC678893 35
  • 88.34 (n)
  • 90.1 (a)
dog
(Canis familiaris)
Mammalia KIAA0247 36
  • 92 (a)
OneToOne
KIAA0247 35
  • 91.09 (n)
  • 92.41 (a)
oppossum
(Monodelphis domestica)
Mammalia KIAA0247 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KIAA0247 36
  • 99 (a)
OneToOne
KIAA0247 35
  • 99.45 (n)
  • 99.01 (a)
chicken
(Gallus gallus)
Aves KIAA0247 35
  • 73.78 (n)
  • 74.67 (a)
KIAA0247 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA0247 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0247 35
  • 65.19 (n)
  • 65.65 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11364 35
si:dkey-11e23.5 35
  • 60.34 (n)
  • 61.66 (a)
si:dkey-11e23.5 36
  • 42 (a)
OneToOne
Species with no ortholog for SUSD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUSD6 Gene

ENSEMBL:
Gene Tree for SUSD6 (if available)
TreeFam:
Gene Tree for SUSD6 (if available)

Paralogs for SUSD6 Gene

Paralogs for SUSD6 Gene

genes like me logo Genes that share paralogs with SUSD6: view

Variants for SUSD6 Gene

Sequence variations from dbSNP and Humsavar for SUSD6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1275741 -- 69,646,231(+) ctgtc(C/T)ctctc intron-variant
rs1275742 -- 69,657,849(-) CACTC(C/T)AGTTC intron-variant, upstream-variant-2KB
rs1275743 -- 69,661,899(+) GGCTG(A/G)AGCAG intron-variant
rs1275744 -- 69,664,354(+) TGCCA(A/T)GGTGG intron-variant
rs1275745 -- 69,664,917(-) TGAGA(C/G)GTGTT intron-variant

Variation tolerance for SUSD6 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUSD6 Gene

HapMap Linkage Disequilibrium report
SUSD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SUSD6 Gene

Disorders for SUSD6 Gene

Relevant External Links for SUSD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUSD6

No disorders were found for SUSD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUSD6 Gene

Publications for SUSD6 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]. (PMID: 24652652) Polato F. … Broggini M. (J. Natl. Cancer Inst. 2014) 3
  5. A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment. (PMID: 21619678) Huang C.J. … Chang C.C. (J Transl Med 2011) 3

Products for SUSD6 Gene

Sources for SUSD6 Gene

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