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Aliases for SUSD6 Gene

Aliases for SUSD6 Gene

  • Sushi Domain Containing 6 2 3 5
  • KIAA0247 2 3 4
  • Drug-Activated Gene Overexpressed Protein 3 4
  • DRAGO 3 4
  • Sushi Domain-Containing Protein 6 3

External Ids for SUSD6 Gene

Previous HGNC Symbols for SUSD6 Gene

  • KIAA0247

Summaries for SUSD6 Gene

GeneCards Summary for SUSD6 Gene

SUSD6 (Sushi Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is SUSD4.

UniProtKB/Swiss-Prot for SUSD6 Gene

  • May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity).

Additional gene information for SUSD6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUSD6 Gene

Genomics for SUSD6 Gene

Regulatory Elements for SUSD6 Gene

Enhancers for SUSD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H069692 1.9 FANTOM5 Ensembl ENCODE dbSUPER 28.8 +86.5 86532 12 HDGF PKNOX1 FOXA2 MLX SIN3A ARID4B DMAP1 SLC30A9 ZNF766 SP5 SUSD6 SRSF5 TTC9 SLC8A3 PIR54293 GC14P069678
GH14H069642 1.8 FANTOM5 Ensembl ENCODE dbSUPER 24.8 +32.4 32364 3 PKNOX1 FOXA2 NFIB INSM2 BRCA1 ZBTB40 YY1 EGR1 ZNF366 ZNF143 SUSD6 SRSF5 DCAF5 GC14P069648 GC14M069622
GH14H069634 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.8 +26.0 25952 6 HDGF FOXA2 PKNOX1 MLX SIN3A ARID4B YY1 TCF12 RUNX3 SP5 SUSD6 SRSF5 DCAF5 GC14M069622 GC14P069648
GH14H069682 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.3 +72.9 72941 5 PKNOX1 FOXA2 ARID4B BATF RAD21 GATA2 ZNF143 RUNX3 CREM JUNB SUSD6 SRSF5 SMOC1 GC14P069678 PIR54293
GH14H069647 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.3 +40.0 40018 8 PKNOX1 FOXA2 ATF1 SIN3A YY1 ZNF207 FOS ATF7 RUNX3 PPARG SUSD6 SRSF5 DCAF5 GC14P069648 GC14P069678
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SUSD6 on UCSC Golden Path with GeneCards custom track

Promoters for SUSD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070243 607 2401 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 GLIS2 ZNF143 FOS RUNX3

Genomic Location for SUSD6 Gene

Chromosome:
14
Start:
69,611,593 bp from pter
End:
69,715,144 bp from pter
Size:
103,552 bases
Orientation:
Plus strand

Genomic View for SUSD6 Gene

Genes around SUSD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUSD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUSD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUSD6 Gene

Proteins for SUSD6 Gene

  • Protein details for SUSD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92537-SUSD6_HUMAN
    Recommended name:
    Sushi domain-containing protein 6
    Protein Accession:
    Q92537

    Protein attributes for SUSD6 Gene

    Size:
    303 amino acids
    Molecular mass:
    32090 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13378.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SUSD6 Gene

Post-translational modifications for SUSD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SUSD6 Gene

No data available for DME Specific Peptides for SUSD6 Gene

Domains & Families for SUSD6 Gene

Gene Families for SUSD6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SUSD6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SUSD6: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SUSD6 Gene

Function for SUSD6 Gene

Molecular function for SUSD6 Gene

UniProtKB/Swiss-Prot Function:
May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by chemotherapeutic DNA-damaging agents and by p53/TP53 and/or by p73/TP73 in response to cytotoxic insults (PubMed:24652652). Up-regulated by lipopolysaccharide (LPS) in monocytic THP1 cells (PubMed:20236627). Up-regulated in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium.

Phenotypes From GWAS Catalog for SUSD6 Gene

Gene Ontology (GO) - Molecular Function for SUSD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SUSD6: view
genes like me logo Genes that share phenotypes with SUSD6: view

Animal Models for SUSD6 Gene

MGI Knock Outs for SUSD6:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SUSD6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUSD6 Gene

Localization for SUSD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUSD6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUSD6 gene
Compartment Confidence
plasma membrane 3
nucleus 3
extracellular 2
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SUSD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SUSD6: view

Pathways & Interactions for SUSD6 Gene

SuperPathways for SUSD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUSD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 24652652
GO:0008219 cell death IDA 24652652
genes like me logo Genes that share ontologies with SUSD6: view

No data available for Pathways by source and SIGNOR curated interactions for SUSD6 Gene

Drugs & Compounds for SUSD6 Gene

No Compound Related Data Available

Transcripts for SUSD6 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SUSD6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SUSD6 Gene

No ASD Table

Relevant External Links for SUSD6 Gene

GeneLoc Exon Structure for
SUSD6
ECgene alternative splicing isoforms for
SUSD6

Expression for SUSD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUSD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SUSD6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUSD6 Gene



Protein tissue co-expression partners for SUSD6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUSD6 Gene:

SUSD6

Evidence on tissue expression from TISSUES for SUSD6 Gene

  • Bone marrow(4.3)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with SUSD6: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUSD6 Gene

Orthologs for SUSD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUSD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0247 34 33
  • 99.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0247 33 34
  • 91.09 (n)
cow
(Bos Taurus)
Mammalia KIAA0247 33 34
  • 90.78 (n)
rat
(Rattus norvegicus)
Mammalia LOC678893 33
  • 88.34 (n)
mouse
(Mus musculus)
Mammalia 4933426M11Rik 33 34
  • 87.97 (n)
Susd6 16
oppossum
(Monodelphis domestica)
Mammalia KIAA0247 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 71 (a)
OneToMany
-- 34
  • 40 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIAA0247 34 33
  • 73.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA0247 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0247 33
  • 65.19 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-11e23.5 33 34
  • 60.34 (n)
Dr.11364 33
Species where no ortholog for SUSD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUSD6 Gene

ENSEMBL:
Gene Tree for SUSD6 (if available)
TreeFam:
Gene Tree for SUSD6 (if available)

Paralogs for SUSD6 Gene

Paralogs for SUSD6 Gene

genes like me logo Genes that share paralogs with SUSD6: view

Variants for SUSD6 Gene

Sequence variations from dbSNP and Humsavar for SUSD6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000004320 -- 69,627,756(+) ACCGT(G/T)CCCGG intron-variant
rs1000063142 -- 69,637,550(+) GCTGT(A/G)TGTGG intron-variant
rs1000088828 -- 69,686,840(+) TTGGG(G/T)GGGGA intron-variant
rs1000143394 -- 69,633,973(+) GGACC(A/G)TCCAG intron-variant
rs1000158694 -- 69,697,786(+) CCAGA(A/G)GGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUSD6 Gene

Variant ID Type Subtype PubMed ID
esv3634840 CNV loss 21293372
esv3634842 CNV loss 21293372
nsv1070641 CNV deletion 25765185
nsv1143612 CNV deletion 24896259
nsv1336 CNV insertion 18451855
nsv456336 CNV gain 19166990
nsv565007 CNV gain 21841781
nsv826971 CNV loss 20364138
nsv952862 CNV duplication 24416366

Variation tolerance for SUSD6 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUSD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUSD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUSD6 Gene

Disorders for SUSD6 Gene

Relevant External Links for SUSD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUSD6

No disorders were found for SUSD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUSD6 Gene

Publications for SUSD6 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 60
  2. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]. (PMID: 24652652) Polato F … Broggini M (Journal of the National Cancer Institute 2014) 3 4 60
  3. Characterization of SVEP1, KIAA, and SRPX2 in an in vitro cell culture model of endotoxemia. (PMID: 20236627) Schwanzer-Pfeiffer D … Falkenhagen D (Cellular immunology 2010) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SUSD6 Gene

Sources for SUSD6 Gene

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