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Aliases for SUSD5 Gene

Aliases for SUSD5 Gene

  • Sushi Domain Containing 5 2 3 5
  • KIAA0527 4

External Ids for SUSD5 Gene

Previous GeneCards Identifiers for SUSD5 Gene

  • GC03M033167

Summaries for SUSD5 Gene

GeneCards Summary for SUSD5 Gene

SUSD5 (Sushi Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include hyaluronic acid binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUSD5 Gene

Genomics for SUSD5 Gene

Regulatory Elements for SUSD5 Gene

Enhancers for SUSD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F033218 0.2 ENCODE 17.6 +0.4 370 1.0 GLIS2 ZNF263 ZNF362 SP3 REST GLIS1 KDM1A PRDM1 ZBTB26 SUZ12 SUSD5 PIR48292
GH03F033298 0.8 Ensembl ENCODE 15.4 -80.9 -80899 2.9 CTCF KLF1 ZNF316 JUND JUN PRDM1 EP300 UBP1 SUSD5 FBXL2 RNU7-110P
GH03F033276 0.6 ENCODE 11.2 -58.7 -58723 2.1 ATF1 PKNOX1 ARID4B SIN3A RAD21 CREM EGR2 ZNF263 SP3 ZNF680 FBXL2 SUSD5 RNU7-110P
GH03F033148 0.8 Ensembl 10.7 +69.8 69814 1.2 POLR2A SUSD5 CRTAP ENSG00000236732 ENSG00000271324 ENSG00000272149 PIR50801
GH03F033131 0.7 ENCODE 10.7 +87.4 87436 0.9 CTCF ZNF654 HLF TEAD4 TSC22D4 TRIM22 REST RAD21 HBP1 TEAD3 TMPPE GLB1 SUSD5 CLASP2 PIR55934 GC03P033114
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SUSD5 on UCSC Golden Path with GeneCards custom track

Promoters for SUSD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001360764 514 1799 PKNOX1 GLIS2 ZNF263 ZNF362 SP3 REST GLIS1 KDM1A PRDM1 ZBTB26

Genomic Location for SUSD5 Gene

Chromosome:
3
Start:
33,150,042 bp from pter
End:
33,219,215 bp from pter
Size:
69,174 bases
Orientation:
Minus strand

Genomic View for SUSD5 Gene

Genes around SUSD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUSD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUSD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUSD5 Gene

Proteins for SUSD5 Gene

  • Protein details for SUSD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60279-SUSD5_HUMAN
    Recommended name:
    Sushi domain-containing protein 5
    Protein Accession:
    O60279

    Protein attributes for SUSD5 Gene

    Size:
    629 amino acids
    Molecular mass:
    68021 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25453.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SUSD5 Gene

Post-translational modifications for SUSD5 Gene

  • Glycosylation at Thr 343 and Ser 470
  • Modification sites at PhosphoSitePlus

Other Protein References for SUSD5 Gene

No data available for DME Specific Peptides for SUSD5 Gene

Domains & Families for SUSD5 Gene

Gene Families for SUSD5 Gene

Suggested Antigen Peptide Sequences for SUSD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60279

UniProtKB/Swiss-Prot:

SUSD5_HUMAN :
  • Contains 1 Link domain.
Domain:
  • Contains 1 Link domain.
  • Contains 1 Sushi (CCP/SCR) domain.
genes like me logo Genes that share domains with SUSD5: view

Function for SUSD5 Gene

Gene Ontology (GO) - Molecular Function for SUSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005540 hyaluronic acid binding IEA --
genes like me logo Genes that share ontologies with SUSD5: view
genes like me logo Genes that share phenotypes with SUSD5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUSD5 Gene

Localization for SUSD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUSD5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUSD5 Gene COMPARTMENTS Subcellular localization image for SUSD5 gene
Compartment Confidence
plasma membrane 3
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SUSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SUSD5: view

Pathways & Interactions for SUSD5 Gene

SuperPathways for SUSD5 Gene

No Data Available

Interacting Proteins for SUSD5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000308727%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000308727 O60279-SUSD5_HUMAN for SUSD5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SUSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007219 Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with SUSD5: view

No data available for Pathways by source and SIGNOR curated interactions for SUSD5 Gene

Drugs & Compounds for SUSD5 Gene

(1) Drugs for SUSD5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma 439
genes like me logo Genes that share compounds with SUSD5: view

Transcripts for SUSD5 Gene

mRNA/cDNA for SUSD5 Gene

Unigene Clusters for SUSD5 Gene

Sushi domain containing 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUSD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for SUSD5 Gene

GeneLoc Exon Structure for
SUSD5
ECgene alternative splicing isoforms for
SUSD5

Expression for SUSD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SUSD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUSD5 Gene

This gene is overexpressed in Artery - Aorta (x17.7), Artery - Tibial (x12.1), and Artery - Coronary (x9.7).

Protein differential expression in normal tissues from HIPED for SUSD5 Gene

This gene is overexpressed in Cerebrospinal fluid (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SUSD5 Gene



Protein tissue co-expression partners for SUSD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SUSD5 Gene:

SUSD5

SOURCE GeneReport for Unigene cluster for SUSD5 Gene:

Hs.196647
genes like me logo Genes that share expression patterns with SUSD5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SUSD5 Gene

Orthologs for SUSD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUSD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUSD5 34 35
  • 98.99 (n)
dog
(Canis familiaris)
Mammalia SUSD5 34 35
  • 84.81 (n)
cow
(Bos Taurus)
Mammalia SUSD5 34 35
  • 81.09 (n)
rat
(Rattus norvegicus)
Mammalia Susd5 34
  • 78.55 (n)
mouse
(Mus musculus)
Mammalia Susd5 34 16 35
  • 78.46 (n)
oppossum
(Monodelphis domestica)
Mammalia SUSD5 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUSD5 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC420721 34
  • 57.39 (n)
SUSD5 35
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUSD5 35
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii susd5 34 35
  • 51.23 (n)
Species where no ortholog for SUSD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUSD5 Gene

ENSEMBL:
Gene Tree for SUSD5 (if available)
TreeFam:
Gene Tree for SUSD5 (if available)

Paralogs for SUSD5 Gene

No data available for Paralogs for SUSD5 Gene

Variants for SUSD5 Gene

Sequence variations from dbSNP and Humsavar for SUSD5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10222491 -- 33,173,669(+) TATAA(A/G)TTCAG intron-variant
rs10576154 -- 33,172,221(+) CACAC(-/AC)TCTTC intron-variant
rs10662721 -- 33,192,819(+) AAAAA(-/AT)ATATA intron-variant
rs10662722 -- 33,193,004(+) TTGTC(-/TGTT)TGGGT intron-variant
rs10707915 -- 33,196,877(+) CTCAG(-/A)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUSD5 Gene

Variant ID Type Subtype PubMed ID
nsv1003285 CNV gain 25217958
nsv1013540 CNV loss 25217958
nsv1109503 CNV deletion 24896259
nsv1123635 CNV deletion 24896259
nsv979818 CNV duplication 23825009

Variation tolerance for SUSD5 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUSD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUSD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUSD5 Gene

Disorders for SUSD5 Gene

Relevant External Links for SUSD5

Genetic Association Database (GAD)
SUSD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUSD5

No disorders were found for SUSD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUSD5 Gene

Publications for SUSD5 Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for SUSD5 Gene

Sources for SUSD5 Gene

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