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Aliases for SUSD5 Gene

Aliases for SUSD5 Gene

  • Sushi Domain Containing 5 2 3 5
  • KIAA0527 4

External Ids for SUSD5 Gene

Previous GeneCards Identifiers for SUSD5 Gene

  • GC03M033167

Summaries for SUSD5 Gene

GeneCards Summary for SUSD5 Gene

SUSD5 (Sushi Domain Containing 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hyaluronic acid binding.

Additional gene information for SUSD5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUSD5 Gene

Genomics for SUSD5 Gene

GeneHancer (GH) Regulatory Elements for SUSD5 Gene

Promoters and enhancers for SUSD5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I033218 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 567.6 +0.3 336 1 ZNF335 GLIS2 ZNF362 SP3 ZNF398 GLIS1 ZNF624 PRDM4 PRDM1 ZBTB26 SUSD5 CRTAP PIR48292
GH03I033276 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.2 -58.7 -58723 2.1 PKNOX1 ATF1 ARID4B SIN3A ZNF143 ATF7 SP3 SP5 NFYC MXD4 FBXL2 SUSD5 RNU7-110P
GH03I033298 Enhancer 0.7 Ensembl ENCODE 15.4 -80.9 -80899 2.9 KLF1 JUND JUN FOSL2 EP300 PRDM1 UBP1 SUSD5 FBXL2 RNU7-110P
GH03I033131 Enhancer 0.9 ENCODE dbSUPER 10.7 +87.4 87435 0.9 CTCF ZNF654 HLF NCOA1 TRIM22 REST RAD21 TEAD3 CC2D1A SP1 TMPPE GLB1 SUSD5 CLASP2 PIR55934 CRTAP GC03P033114
GH03I033355 Enhancer 0.9 Ensembl ENCODE 10.4 -136.6 -136610 1.1 HDAC1 MEIS2 ATF1 PKNOX1 ARNT CEBPG MTA3 SCRT2 GATAD2A SOX6 FBXL2 SUSD5 UBP1 RNU7-110P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SUSD5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SUSD5 gene promoter:

Genomic Locations for SUSD5 Gene

Genomic Locations for SUSD5 Gene
69,174 bases
Minus strand

Genomic View for SUSD5 Gene

Genes around SUSD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUSD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUSD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUSD5 Gene

Proteins for SUSD5 Gene

  • Protein details for SUSD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sushi domain-containing protein 5
    Protein Accession:

    Protein attributes for SUSD5 Gene

    629 amino acids
    Molecular mass:
    68021 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA25453.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SUSD5 Gene

Post-translational modifications for SUSD5 Gene

  • Glycosylation at isoforms=343 and posLast=470470

Other Protein References for SUSD5 Gene

No data available for DME Specific Peptides for SUSD5 Gene

Domains & Families for SUSD5 Gene

Gene Families for SUSD5 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for SUSD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SUSD5: view

No data available for UniProtKB/Swiss-Prot for SUSD5 Gene

Function for SUSD5 Gene

Gene Ontology (GO) - Molecular Function for SUSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005540 hyaluronic acid binding IEA --
genes like me logo Genes that share ontologies with SUSD5: view
genes like me logo Genes that share phenotypes with SUSD5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUSD5 Gene

Localization for SUSD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUSD5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUSD5 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SUSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SUSD5: view

Pathways & Interactions for SUSD5 Gene

SuperPathways for SUSD5 Gene

No Data Available

Interacting Proteins for SUSD5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: O60279-SUSD5_HUMAN ENSP00000308727 for SUSD5 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SUSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007219 Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with SUSD5: view

No data available for Pathways by source and SIGNOR curated interactions for SUSD5 Gene

Drugs & Compounds for SUSD5 Gene

(1) Drugs for SUSD5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma 535
genes like me logo Genes that share compounds with SUSD5: view

Transcripts for SUSD5 Gene

mRNA/cDNA for SUSD5 Gene

Unigene Clusters for SUSD5 Gene

Sushi domain containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUSD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: -

Relevant External Links for SUSD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SUSD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUSD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUSD5 Gene

This gene is overexpressed in Artery - Aorta (x17.7), Artery - Tibial (x12.1), and Artery - Coronary (x9.7).

Protein differential expression in normal tissues from HIPED for SUSD5 Gene

This gene is overexpressed in Cerebrospinal fluid (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUSD5 Gene

Protein tissue co-expression partners for SUSD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SUSD5 Gene:


SOURCE GeneReport for Unigene cluster for SUSD5 Gene:


Evidence on tissue expression from TISSUES for SUSD5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SUSD5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUSD5 Gene

Orthologs for SUSD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUSD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SUSD5 33 34
  • 98.99 (n)
(Canis familiaris)
Mammalia SUSD5 33 34
  • 84.81 (n)
(Bos Taurus)
Mammalia SUSD5 33 34
  • 81.09 (n)
(Rattus norvegicus)
Mammalia Susd5 33
  • 78.55 (n)
(Mus musculus)
Mammalia Susd5 33 16 34
  • 78.46 (n)
(Monodelphis domestica)
Mammalia SUSD5 34
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia SUSD5 34
  • 45 (a)
(Gallus gallus)
Aves LOC420721 33
  • 57.39 (n)
SUSD5 34
  • 45 (a)
(Anolis carolinensis)
Reptilia SUSD5 34
  • 43 (a)
(Danio rerio)
Actinopterygii susd5 33 34
  • 51.23 (n)
Species where no ortholog for SUSD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUSD5 Gene

Gene Tree for SUSD5 (if available)
Gene Tree for SUSD5 (if available)

Paralogs for SUSD5 Gene

No data available for Paralogs for SUSD5 Gene

Variants for SUSD5 Gene

Sequence variations from dbSNP and Humsavar for SUSD5 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000036359 -- 33,167,553(-) C/T intron_variant
rs1000128632 -- 33,192,055(-) G/A intron_variant
rs1000166458 -- 33,175,433(-) A/G intron_variant
rs1000195415 -- 33,219,679(-) G/A upstream_transcript_variant
rs1000234061 -- 33,185,018(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SUSD5 Gene

Variant ID Type Subtype PubMed ID
nsv1003285 CNV gain 25217958
nsv1013540 CNV loss 25217958
nsv1109503 CNV deletion 24896259
nsv1123635 CNV deletion 24896259
nsv979818 CNV duplication 23825009

Variation tolerance for SUSD5 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUSD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUSD5 Gene

Disorders for SUSD5 Gene

Additional Disease Information for SUSD5

No disorders were found for SUSD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUSD5 Gene

Publications for SUSD5 Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 58

Products for SUSD5 Gene

Sources for SUSD5 Gene

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