SUSD4 Gene
protein-coding GIFtS : 48
GCID: GC01 M223394
sushi domain containing 4
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Aliasesfor SUSD4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Sushi Domain Containing 4 1 2 FLJ100521 PRO2222 YHGM1962 Sushi Domain-Containing Protein 42
Export aliases for SUSD4 gene to outside databases Previous GC identifers: GC01M219767 GC01M221460 GC01M194069
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Summariesfor SUSD4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor SUSD4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_167186.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SUSD4 gene promoter: SRF STAT1 AML1a GATA-3 SRF (504 AA) STAT1beta STAT1alpha GATA-1 GATA-2 Msx-1 Other transcription factors Search SABiosciences Chromatin IP Primers for SUSD4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SUSD4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q41 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q41 SUSD4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M223394: view genomic region
(about GC identifiers )
Start:
223,394,161 bp from pter
End:
223,537,544 bp from pter
Size:
143,384 bases
Orientation:
minus strand
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Proteinsfor SUSD4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SUSD4_HUMAN, Q5VX71 (See
protein sequence )Recommended Name: Sushi domain-containing protein 4 precursor Size : 490 amino acids; 53778 Da
Subcellular location : Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions : D3DTB9 Q6UX62 Q9BSR0 Q9NWG0Alternative splicing : 4 isoforms : Q5VX71-1 Q5VX71-2 Q5VX71-3 Q5VX71-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SUSD4: NX_Q5VX71 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5VX71 SUSD4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001032252.1 NP_060452.3 ENSEMBL proteins: ENSP00000344219 ENSP00000339926 ENSP00000340917 ENSP00000355843 ENSP00000399288 ENSP00000355842 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
SUSD4 for ontologies About GeneDecksing SUSD4 Antibody Products: Assay Products for SUSD4:
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Protein
Domains / Familiesfor SUSD4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SUSD4 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q5VX71 ProtoNet protein and cluster: Q5VX71
1 Blocks protein family : IPB000436 Sushi domain/SCR domain/CCP module UniProtKB/Swiss-Prot: SUSD4_HUMAN, Q5VX71 Similarity : Contains 4 Sushi (CCP/SCR) domains
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Functionfor SUSD4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SUSD4 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SUSD4 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SUSD4 (NM_017982 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SUSD4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SUSD4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUSD4
1 GenomeRNAi human phenotype for SUSD4 :Animal Models: Mouse knock-out Susd4 tm1Lex for SUSD4 1 MGI phenotypic allele for Susd4 (no phenotypes)
SUSD4 for phenotypes About GeneDecksing
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Pathways & Interactionsfor SUSD4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SUSD4 5/6 Interacting proteins for SUSD4 (Q5VX71 2 , 3 ) via UniProtKB, MINT, STRING, and/or I2D (see all 6 )About this table
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Drugs & Compoundsfor SUSD4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SUSD4 Search CenterWatch for drugs/clinical trials and news about SUSD4
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Transcriptsfor SUSD4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SUSD4 gene (2 alternative transcripts): NM_001037175.2 NM_017982.3 Unigene Cluster for SUSD4:
Sushi domain containing 4 Hs.497841 [show with all ESTs ] Unigene Representative Sequence: AK096265 13 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000343846 (uc001hnx.3 ) ENST00000494793 ENST00000478605 ENST00000483818 ENST00000484503 ENST00000470249 ENST00000484758 ENST00000344029 (uc001hnz.2 )ENST00000497669 ENST00000342943 ENST00000366878 (uc001hny.4 uc010puw.2 uc010pux.1 )ENST00000454695 ENST00000366877 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SUSD4 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SUSD4 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SUSD4 (NM_017982 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SUSD4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SUSD4
Additional cDNA sequence: AK000914.1 AK096265.1 AK295553.1 AK296923.1 AY358495.1 BC004888.2 EF560748.1
12 DOTS entries : DT.100749746 DT.40127876
DT.411506 DT.40127212 DT.100675234 DT.91713619 DT.91888592 DT.97796827 DT.121337348 DT.91661507 DT.92051348 DT.99933510 24/99 AceView cDNA sequences (see all 99 ):
BM311465 AI628101 BE671439 AK000914 AA335726 AA988038 AA418002 BF447665 BC004888 AI538781 BE744704 BQ045203 AI417581 BM849437 BP360736 AW204351 AI984400 AI090524 BQ128216 CA942864 AI701529 BE503579 BE644888 F12032 GeneLoc Exon Structure
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Expression for SUSD4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SUSD4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTGATCTGTG
About this image SUSD4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SUSD4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SUSD4 SOURCE GeneReport for Unigene cluster: Hs.497841 SABiosciences Custom PCR Arrays for SUSD4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SUSD4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SUSD4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SUSD4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SUSD4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUSD4
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Orthologsfor SUSD4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for SUSD4 gene from 3/10 species (see all 10 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
SUSD41
sushi domain containing 4
73.32(n) 73.7(a)
 
770442 XM_001233776.2 XP_001233777.2
lizard (Anolis carolinensis)
Reptilia
SUSD46
--
75(a)
1 ↔ 1
1(244767376-244773161)
zebrafish (Danio rerio)
Actinopterygii
LOC5603041
sushi domain-containing protein 4-like
63.3(n) 58.92(a)
 
560304 XM_683701.2 XP_688793.1
ENSEMBL Gene Tree for SUSD4 (if available)TreeFam Gene Tree for SUSD4 (if available)
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Paralogsfor SUSD4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SUSD4 gene KIAA0247 2 1 SIMAP similar gene for SUSD4 using alignment to 4 protein entries: SUSD4_HUMAN (see all proteins ):KIAA0247
SUSD4 for paralogs About GeneDecksing
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Genomic Variantsfor SUSD4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SUSD4 (223394161 - 223537544 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for SUSD4 1 Indel : 48247
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SUSD4
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Disorders
/ Diseasesfor SUSD4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SUSD4 for disorders About GeneDecksing 3 diseases for SUSD4 : About MalaCards fryns syndrome hepatitis b hepatitis Human Genome Epidemiology (HuGE) Navigator: SUSD4 (1 document)Export disorders for SUSD4 gene to outside databases
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Publicationsfor SUSD4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SUSD4 gene integrated from 9 sources : (articles sorted by number of sources associating them with SUSD4) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496) 1 Davila S....Seielstad M. (2010) Tissue distribution and functional analysis of Sushi domain-containing protein 4. (PubMed id 20348246) 1 Tu Z....Lin F. (2010) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004)
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External Searches for SUSD4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SUSD4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SUSD4 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SUSD4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SUSD4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SUSD4 gene: Search GeneIP for patents involving SUSD4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SUSD4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SUSD4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SUSD4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SUSD4 OriGene Protein Over-expression Lysate for SUSD4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SUSD4 OriGene 3'-UTR Clone for SUSD4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SUSD4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SUSD4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SUSD4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SUSD4 OriGene Custom Protein Services for SUSD4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SUSD4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SUSD4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SUSD4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SUSD4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SUSD4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SUSD4
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUSD4
ThermoFisher Antibodies for SUSD4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SUSD4
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