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Aliases for SUSD4 Gene

Aliases for SUSD4 Gene

  • Sushi Domain Containing 4 2 3
  • Sushi Domain-Containing Protein 4 3
  • YHGM196 3
  • PRO222 3

External Ids for SUSD4 Gene

Previous GeneCards Identifiers for SUSD4 Gene

  • GC01M219767
  • GC01M221460
  • GC01M223394
  • GC01M194069

Summaries for SUSD4 Gene

GeneCards Summary for SUSD4 Gene

SUSD4 (Sushi Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is SUSD6.

UniProtKB/Swiss-Prot for SUSD4 Gene

  • Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUSD4 Gene

Genomics for SUSD4 Gene

Regulatory Elements for SUSD4 Gene

Genomic Location for SUSD4 Gene

Start:
223,220,819 bp from pter
End:
223,364,202 bp from pter
Size:
143,384 bases
Orientation:
Minus strand

Genomic View for SUSD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUSD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUSD4 Gene

Proteins for SUSD4 Gene

  • Protein details for SUSD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VX71-SUSD4_HUMAN
    Recommended name:
    Sushi domain-containing protein 4
    Protein Accession:
    Q5VX71
    Secondary Accessions:
    • D3DTB9
    • Q6UX62
    • Q9BSR0
    • Q9NWG0

    Protein attributes for SUSD4 Gene

    Size:
    490 amino acids
    Molecular mass:
    53778 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SUSD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUSD4 Gene

Proteomics data for SUSD4 Gene at MOPED

Post-translational modifications for SUSD4 Gene

  • Glycosylation at Asn104, Asn134, and Asn192
  • Modification sites at PhosphoSitePlus

Other Protein References for SUSD4 Gene

No data available for DME Specific Peptides for SUSD4 Gene

Domains for SUSD4 Gene

Protein Domains for SUSD4 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VX71

UniProtKB/Swiss-Prot:

SUSD4_HUMAN :
  • Q5VX71
Domain:
  • Contains 4 Sushi (CCP/SCR) domains.
genes like me logo Genes that share domains with SUSD4: view

No data available for Gene Families for SUSD4 Gene

Function for SUSD4 Gene

Molecular function for SUSD4 Gene

UniProtKB/Swiss-Prot Function: Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.

Phenotypes for SUSD4 Gene

GenomeRNAi human phenotypes for SUSD4:
genes like me logo Genes that share phenotypes with SUSD4: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SUSD4 Gene

Localization for SUSD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUSD4 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUSD4 Gene COMPARTMENTS Subcellular localization image for SUSD4 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SUSD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SUSD4: view

Pathways for SUSD4 Gene

SuperPathways for SUSD4 Gene

No Data Available

Interacting Proteins for SUSD4 Gene

Gene Ontology (GO) - Biological Process for SUSD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006958 complement activation, classical pathway IEA --
GO:0030449 regulation of complement activation IDA 23482636
GO:0045087 innate immune response IEA --
GO:0045957 negative regulation of complement activation, alternative pathway IDA 23482636
GO:0045959 negative regulation of complement activation, classical pathway IDA 23482636
genes like me logo Genes that share ontologies with SUSD4: view

No data available for Pathways by source for SUSD4 Gene

Transcripts for SUSD4 Gene

Unigene Clusters for SUSD4 Gene

Sushi domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUSD4 Gene

No ASD Table

Relevant External Links for SUSD4 Gene

GeneLoc Exon Structure for
SUSD4
ECgene alternative splicing isoforms for
SUSD4

Expression for SUSD4 Gene

mRNA expression in normal human tissues for SUSD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUSD4 Gene

This gene is overexpressed in Brain - Hippocampus (4.3).

SOURCE GeneReport for Unigene cluster for SUSD4 Gene Hs.497841

mRNA Expression by UniProt/SwissProt for SUSD4 Gene

Q5VX71-SUSD4_HUMAN
Tissue specificity: Isoform 3 is the predominant isoform in all tissues except cortex, cerebellum, kidney, and breast. Isoform 1 is found primarily in the esophagus and the brain.
genes like me logo Genes that share expressions with SUSD4: view

No data available for Protein expression for SUSD4 Gene

Orthologs for SUSD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUSD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUSD4 35
  • 98.7 (n)
  • 98.57 (a)
SUSD4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUSD4 35
  • 91.63 (n)
  • 93.27 (a)
SUSD4 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUSD4 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Susd4 35
  • 88.71 (n)
  • 91.22 (a)
Susd4 16
Susd4 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUSD4 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUSD4 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Susd4 35
  • 89.39 (n)
  • 91.63 (a)
chicken
(Gallus gallus)
Aves SUSD4 35
  • 73.26 (n)
  • 73.64 (a)
SUSD4 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUSD4 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tlr5 35
  • 68.57 (n)
  • 63.3 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560304 35
  • 63.27 (n)
  • 59.72 (a)
susd4 36
  • 50 (a)
OneToOne
Species with no ortholog for SUSD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUSD4 Gene

ENSEMBL:
Gene Tree for SUSD4 (if available)
TreeFam:
Gene Tree for SUSD4 (if available)

Paralogs for SUSD4 Gene

Paralogs for SUSD4 Gene

Selected SIMAP similar genes for SUSD4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SUSD4: view

Variants for SUSD4 Gene

Sequence variations from dbSNP and Humsavar for SUSD4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2854 -- 223,220,968(+) AGGAA(A/T)GGAAT utr-variant-3-prime
rs712856 -- 223,294,994(+) ACTTC(A/G)TACCA intron-variant
rs712857 -- 223,261,291(-) ATACT(C/T)TTATA intron-variant
rs712858 -- 223,260,602(-) GCTTC(C/G)TGCAT intron-variant
rs712859 -- 223,254,773(-) TTCCT(C/T)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUSD4 Gene

Variant ID Type Subtype PubMed ID
nsv832659 CNV Gain 17160897
nsv516810 CNV Gain 19592680
nsv518979 CNV Gain 19592680
nsv826809 CNV Gain 20364138

Relevant External Links for SUSD4 Gene

HapMap Linkage Disequilibrium report
SUSD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUSD4 Gene

Disorders for SUSD4 Gene

Relevant External Links for SUSD4

Genetic Association Database (GAD)
SUSD4
Human Genome Epidemiology (HuGE) Navigator
SUSD4
genes like me logo Genes that share disorders with SUSD4: view

No data available for UniProtKB/Swiss-Prot for SUSD4 Gene

Publications for SUSD4 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Sushi domain-containing protein 4 (SUSD4) inhibits complement by disrupting the formation of the classical C3 convertase. (PMID: 23482636) Holmquist E. … Blom A.M. (FASEB J. 2013) 3 4
  5. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 48

Products for SUSD4 Gene

Sources for SUSD4 Gene

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