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Aliases for SUSD3 Gene

Aliases for SUSD3 Gene

  • Sushi Domain Containing 3 2 3 5

External Ids for SUSD3 Gene

Previous GeneCards Identifiers for SUSD3 Gene

  • GC09P091162
  • GC09P092900
  • GC09P094860
  • GC09P095820
  • GC09P065497

Summaries for SUSD3 Gene

GeneCards Summary for SUSD3 Gene

SUSD3 (Sushi Domain Containing 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SUSD3 Gene

  • May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUSD3 Gene

Genomics for SUSD3 Gene

Regulatory Elements for SUSD3 Gene

Enhancers for SUSD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SUSD3 on UCSC Golden Path with GeneCards custom track

Promoters for SUSD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUSD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUSD3 Gene

93,058,688 bp from pter
93,085,138 bp from pter
26,451 bases
Plus strand

Genomic View for SUSD3 Gene

Genes around SUSD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUSD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUSD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUSD3 Gene

Proteins for SUSD3 Gene

  • Protein details for SUSD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sushi domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • Q49AA6
    • Q6UXV7

    Protein attributes for SUSD3 Gene

    255 amino acids
    Molecular mass:
    27119 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SUSD3 Gene


neXtProt entry for SUSD3 Gene

Proteomics data for SUSD3 Gene at MOPED

Post-translational modifications for SUSD3 Gene

  • Glycosylation at Asn 27
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for SUSD3

No data available for DME Specific Peptides for SUSD3 Gene

Domains & Families for SUSD3 Gene

Gene Families for SUSD3 Gene

Protein Domains for SUSD3 Gene

Suggested Antigen Peptide Sequences for SUSD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Sushi (CCP/SCR) domain.
  • Contains 1 Sushi (CCP/SCR) domain.
genes like me logo Genes that share domains with SUSD3: view

Function for SUSD3 Gene

Molecular function for SUSD3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon treatment with estradiol in MCF7 cells.

Phenotypes for SUSD3 Gene

genes like me logo Genes that share phenotypes with SUSD3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SUSD3

miRNA for SUSD3 Gene

miRTarBase miRNAs that target SUSD3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUSD3 Gene

Localization for SUSD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUSD3 Gene

Cell membrane; Single-pass membrane protein. Note=Prominently localized to cell-cell borders. {ECO:0000269 PubMed:24413080}.

Subcellular locations from

Jensen Localization Image for SUSD3 Gene COMPARTMENTS Subcellular localization image for SUSD3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SUSD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 24413080
genes like me logo Genes that share ontologies with SUSD3: view

Pathways & Interactions for SUSD3 Gene

SuperPathways for SUSD3 Gene

No Data Available

Interacting Proteins for SUSD3 Gene

Gene Ontology (GO) - Biological Process for SUSD3 Gene


No data available for Pathways by source and SIGNOR curated interactions for SUSD3 Gene

Drugs & Compounds for SUSD3 Gene

No Compound Related Data Available

Transcripts for SUSD3 Gene

Unigene Clusters for SUSD3 Gene

Sushi domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUSD3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - -
SP2: - - - -
SP3: - - - - -

Relevant External Links for SUSD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SUSD3 Gene

mRNA expression in normal human tissues for SUSD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUSD3 Gene

This gene is overexpressed in Testis (x8.4) and Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for SUSD3 Gene

This gene is overexpressed in Adipocyte (56.5) and CD8 Tcells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SUSD3 Gene

SOURCE GeneReport for Unigene cluster for SUSD3 Gene Hs.88417

mRNA Expression by UniProt/SwissProt for SUSD3 Gene

Tissue specificity: Highly expressed in estrogen receptor-positive breast tumors.
genes like me logo Genes that share expression patterns with SUSD3: view

Protein tissue co-expression partners for SUSD3 Gene

Primer Products

Orthologs for SUSD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUSD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SUSD3 35
  • 76.55 (n)
  • 67.8 (a)
SUSD3 36
  • 65 (a)
(Mus musculus)
Mammalia Susd3 35
  • 75.4 (n)
  • 69.76 (a)
Susd3 16
Susd3 36
  • 64 (a)
(Pan troglodytes)
Mammalia SUSD3 35
  • 99.08 (n)
  • 99.21 (a)
SUSD3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Susd3 35
  • 77.15 (n)
  • 70.56 (a)
(Canis familiaris)
Mammalia SUSD3 36
  • 56 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
-- 36
  • 55 (a)
-- 36
  • 15 (a)
(Ornithorhynchus anatinus)
Mammalia SUSD3 36
  • 47 (a)
(Gallus gallus)
Aves SUSD3 36
  • 39 (a)
(Anolis carolinensis)
Reptilia SUSD3 36
  • 37 (a)
(Danio rerio)
Actinopterygii SUSD3 36
  • 27 (a)
Species with no ortholog for SUSD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUSD3 Gene

Gene Tree for SUSD3 (if available)
Gene Tree for SUSD3 (if available)

Paralogs for SUSD3 Gene

No data available for Paralogs for SUSD3 Gene

Variants for SUSD3 Gene

Sequence variations from dbSNP and Humsavar for SUSD3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1131773 - 93,077,974(+) AGAGC(A/G)AGCGG reference, missense
VAR_035663 A breast cancer sample
rs1131768 -- 93,075,788(+) GGCAC(A/C/G)TGCGC intron-variant, reference, synonymous-codon, utr-variant-5-prime
rs1134127 -- 93,075,611(-) AGACC(A/G/T)GGGGA intron-variant
rs7849306 -- 93,085,322(+) atctc(C/T)gctca downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SUSD3 Gene

Variant ID Type Subtype PubMed ID
nsv526296 CNV Loss 19592680
nsv893575 CNV Loss 21882294
nsv893576 CNV Gain 21882294
dgv8260n71 CNV Loss 21882294
esv2659260 CNV Deletion 23128226
esv32996 CNV Gain 17666407
esv2738780 CNV Deletion 23290073

Variation tolerance for SUSD3 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.86; 79.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SUSD3 Gene

Disorders for SUSD3 Gene

Relevant External Links for SUSD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SUSD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUSD3 Gene

Publications for SUSD3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Estrogen-dependent sushi domain containing 3 regulates cytoskeleton organization and migration in breast cancer cells. (PMID: 24413080) Moy I. … Bulun S.E. (Oncogene 2014) 3
  4. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for SUSD3 Gene

Sources for SUSD3 Gene