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Aliases for SUSD3 Gene

Aliases for SUSD3 Gene

  • Sushi Domain Containing 3 2 3 5

External Ids for SUSD3 Gene

Previous GeneCards Identifiers for SUSD3 Gene

  • GC09P091162
  • GC09P092900
  • GC09P094860
  • GC09P095820
  • GC09P065497

Summaries for SUSD3 Gene

GeneCards Summary for SUSD3 Gene

SUSD3 (Sushi Domain Containing 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SUSD3 Gene

  • May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration.

Additional gene information for SUSD3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUSD3 Gene

Genomics for SUSD3 Gene

Regulatory Elements for SUSD3 Gene

Enhancers for SUSD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H092960 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.7 -92.5 -92514 11.3 HDGF PKNOX1 TBL1XR1 SIN3A ARID4B BATF RFX5 ZNF143 FOS ATF7 FGD3 SUSD3 CENPP SPTLC1 NINJ1 IPPK CARD19 FAM120AOS FAM120A LOC101927954
GH09H092952 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16.5 -104.7 -104688 2.2 KLF1 ZNF3 ZNF366 EED IKZF1 RUNX3 IKZF2 FGD3 SUSD3 FAM120AOS LOC101927954
GH09H093056 1.6 FANTOM5 ENCODE dbSUPER 14.4 +2.8 2846 9.5 HDGF PKNOX1 FOXA2 ARNT SIN3A ARID4B YY1 ZNF766 ZNF143 ZNF207 FGD3 CARD19 SUSD3 LOC101927993 FAM120AOS
GH09H093118 2 FANTOM5 Ensembl ENCODE dbSUPER 11 +61.5 61520 3.2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF143 FOS DEK NINJ1 CARD19 SUSD3 IPPK PHF2
GH09H093090 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +37.0 36982 9.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF207 ZNF143 PHF2 LINC00475 NOL8 NINJ1 CARD19 IARS ZNF484 SUSD3 IPPK LOC101927993
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SUSD3 on UCSC Golden Path with GeneCards custom track

Promoters for SUSD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000237990 312 801 TBP HDGF RB1 SIN3A EGR1 ZNF143 ATF7 IKZF2 SMARCA5 SP5

Genomic Locations for SUSD3 Gene

Genomic Locations for SUSD3 Gene
chr9:93,058,688-93,085,138
(GRCh38/hg38)
Size:
26,451 bases
Orientation:
Plus strand
chr9:95,820,989-95,847,420
(GRCh37/hg19)

Genomic View for SUSD3 Gene

Genes around SUSD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUSD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUSD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUSD3 Gene

Proteins for SUSD3 Gene

  • Protein details for SUSD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L08-SUSD3_HUMAN
    Recommended name:
    Sushi domain-containing protein 3
    Protein Accession:
    Q96L08
    Secondary Accessions:
    • Q49AA6
    • Q6UXV7

    Protein attributes for SUSD3 Gene

    Size:
    255 amino acids
    Molecular mass:
    27119 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SUSD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUSD3 Gene

Post-translational modifications for SUSD3 Gene

  • Glycosylation at Asn27
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SUSD3 Gene

Domains & Families for SUSD3 Gene

Gene Families for SUSD3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SUSD3 Gene

Suggested Antigen Peptide Sequences for SUSD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SUSD3: view

No data available for UniProtKB/Swiss-Prot for SUSD3 Gene

Function for SUSD3 Gene

Molecular function for SUSD3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon treatment with estradiol in MCF7 cells.

Phenotypes for SUSD3 Gene

genes like me logo Genes that share phenotypes with SUSD3: view

Animal Model Products

miRNA for SUSD3 Gene

miRTarBase miRNAs that target SUSD3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUSD3 Gene

Localization for SUSD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUSD3 Gene

Cell membrane; Single-pass membrane protein. Note=Prominently localized to cell-cell borders. {ECO:0000269 PubMed:24413080}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUSD3 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SUSD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 24413080
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SUSD3: view

Pathways & Interactions for SUSD3 Gene

SuperPathways for SUSD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUSD3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SUSD3 Gene

Drugs & Compounds for SUSD3 Gene

No Compound Related Data Available

Transcripts for SUSD3 Gene

Unigene Clusters for SUSD3 Gene

Sushi domain containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUSD3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5:

Relevant External Links for SUSD3 Gene

GeneLoc Exon Structure for
SUSD3
ECgene alternative splicing isoforms for
SUSD3

Expression for SUSD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUSD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUSD3 Gene

This gene is overexpressed in Testis (x8.4) and Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for SUSD3 Gene

This gene is overexpressed in Adipocyte (56.5) and CD8 Tcells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUSD3 Gene



Protein tissue co-expression partners for SUSD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SUSD3 Gene:

SUSD3

SOURCE GeneReport for Unigene cluster for SUSD3 Gene:

Hs.88417

mRNA Expression by UniProt/SwissProt for SUSD3 Gene:

Q96L08-SUSD3_HUMAN
Tissue specificity: Highly expressed in estrogen receptor-positive breast tumors.
genes like me logo Genes that share expression patterns with SUSD3: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUSD3 Gene

Orthologs for SUSD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUSD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUSD3 33 34
  • 99.08 (n)
rat
(Rattus norvegicus)
Mammalia Susd3 33
  • 77.15 (n)
cow
(Bos Taurus)
Mammalia SUSD3 33 34
  • 76.55 (n)
mouse
(Mus musculus)
Mammalia Susd3 33 16 34
  • 75.4 (n)
dog
(Canis familiaris)
Mammalia SUSD3 34
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 55 (a)
OneToMany
-- 34
  • 39 (a)
OneToMany
-- 34
  • 15 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SUSD3 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUSD3 34
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUSD3 34
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SUSD3 34
  • 27 (a)
OneToOne
Species where no ortholog for SUSD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUSD3 Gene

ENSEMBL:
Gene Tree for SUSD3 (if available)
TreeFam:
Gene Tree for SUSD3 (if available)

Paralogs for SUSD3 Gene

No data available for Paralogs for SUSD3 Gene

Variants for SUSD3 Gene

Sequence variations from dbSNP and Humsavar for SUSD3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_035663 A breast cancer sample
rs1000181180 -- 93,071,302(+) CCTCA(A/G)AAGTA intron-variant
rs1000225592 -- 93,060,860(+) AAAAC(A/G)TAGCA intron-variant, upstream-variant-2KB
rs1000241023 -- 93,077,557(+) AAATA(C/T)CCCCT intron-variant
rs1000406804 -- 93,083,668(+) GTGGA(A/G)TCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUSD3 Gene

Variant ID Type Subtype PubMed ID
nsv526296 CNV loss 19592680
esv3621095 CNV loss 21293372
esv3573291 CNV loss 25503493
esv32996 CNV gain 17666407
esv2738780 CNV deletion 23290073
esv2659260 CNV deletion 23128226

Variation tolerance for SUSD3 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.86; 79.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUSD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUSD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUSD3 Gene

Disorders for SUSD3 Gene

Relevant External Links for SUSD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUSD3

No disorders were found for SUSD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUSD3 Gene

Publications for SUSD3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. Estrogen-dependent sushi domain containing 3 regulates cytoskeleton organization and migration in breast cancer cells. (PMID: 24413080) Moy I … Bulun SE (Oncogene 2015) 3 4 60
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SUSD3 Gene

Sources for SUSD3 Gene

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