SUSD2 Gene
protein-coding GIFtS : 49
GCID: GC22 P024577
sushi domain containing 2
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Aliasesfor SUSD2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Sushi Domain Containing 2 1 2 BK65A6.21 2 FLJ227781 Sushi Domain (SCR Repeat) Containing2 Sushi Domain-Containing Protein 22
Export aliases for SUSD2 gene to outside databases Previous GC identifers: GC22P022902 GC22P022903 GC22P022904 GC22P022907 GC22P007526
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Summariesfor SUSD2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor SUSD2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000022.10 NC_018933.1 NT_011520.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SUSD2 gene promoter: GR AML1a Pax-5 Lmo2 MIF-1 Nkx2-5 AREB6 SRY GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for SUSD2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SUSD2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 22q11-q12 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11-q12 SUSD2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 22 GeneLoc Exon Structure
GeneLoc location for GC22P024577: view genomic region
(about GC identifiers )
Start:
24,577,227 bp from pter
End:
24,585,078 bp from pter
Size:
7,852 bases
Orientation:
plus strand
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Proteinsfor SUSD2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SUSD2_HUMAN, Q9UGT4 (See
protein sequence )Recommended Name: Sushi domain-containing protein 2 precursor Size : 822 amino acids; 90208 Da
Subcellular location : Membrane; Single-pass type I membrane protein (Potential)
Sequence caution : Sequence=BAB15481.1; Type=Frameshift; Positions=165;
Secondary accessions : Q9H5Y6Explore the universe of human proteins at neXtProt for SUSD2: NX_Q9UGT4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9UGT4 SUSD2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_062547.1 ENSEMBL proteins: ENSP00000351075 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
SUSD2 for ontologies About GeneDecksing SUSD2 Antibody Products: Assay Products for SUSD2:
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Protein
Domains / Familiesfor SUSD2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SUSD2 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9UGT4 ProtoNet protein and cluster: Q9UGT4
2 Blocks protein families : IPB000436 Sushi domain/SCR domain/CCP module IPB001846 Von Willebrand factor UniProtKB/Swiss-Prot: SUSD2_HUMAN, Q9UGT4 Similarity : Contains 1 AMOP domainSimilarity : Contains 1 SMB (somatomedin-B) domainSimilarity : Contains 1 Sushi (CCP/SCR) domainSimilarity : Contains 1 VWFD domain
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Functionfor SUSD2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SUSD2 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SUSD2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SUSD2 (NM_019601 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SUSD2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SUSD2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUSD2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005044 scavenger receptor activity
IEA -- GO:0030247 polysaccharide binding
IEA --
SUSD2 for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for SUSD2 :
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Pathways & Interactionsfor SUSD2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SUSD2 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)3 Interacting proteins for SUSD2 (Q9UGT4 2 , 3 ENSP00000351075 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006955 immune response
IEA --
SUSD2 for ontologies About GeneDecksing
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Drugs & Compoundsfor SUSD2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SUSD2 Search CenterWatch for drugs/clinical trials and news about SUSD2
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Transcriptsfor SUSD2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SUSD2 gene: NM_019601.3 Unigene Cluster for SUSD2:
Sushi domain containing 2 Hs.131819 [show with all ESTs ] Unigene Representative Sequence: NM_019601 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000358321 (uc002zzn.1 ) ENST00000463101 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SUSD2 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SUSD2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SUSD2 (NM_019601 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SUSD2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SUSD2
Additional cDNA sequence: AK026431.1 BC033107.1
4 DOTS entries : DT.65286013 DT.100745483
DT.91675693 DT.95260094 24/99 AceView cDNA sequences (see all 99 ):
AA330586 BM698894 AI640254 AW772466 AI867336 CK823456 BM966933 AK126105 BU683505 AW193262 BU737917 CA488123 CA489874 CA439535 CA489631 BC033107 BM994044 CN484058 CA454118 AI269365 CA488229 CA487788 BU541692 BU948537 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for SUSD2 About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b SP1 :   -                                     SP2 :                                       SP3 :                                      
ECgene alternative splicing isoforms for SUSD2
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Expression for SUSD2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SUSD2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAGAGCCTGC
About this image SUSD2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SUSD2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SUSD2 SOURCE GeneReport for Unigene cluster: Hs.131819 SABiosciences Custom PCR Arrays for SUSD2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SUSD2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SUSD2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SUSD2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SUSD2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUSD2
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Orthologsfor SUSD2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for SUSD2 gene from 5/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for SUSD2 (if available)TreeFam Gene Tree for SUSD2 (if available)
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Paralogsfor SUSD2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SUSD2 gene MUC4 2
SUSD2 for paralogs About GeneDecksing 2 Pseudogenes.org Pseudogenes for SUSD2 PGOHUM00000246237 PGOHUM00000246427
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Genomic Variantsfor SUSD2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 22 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SUSD2 (24577227 - 24585078 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for SUSD2 5 CNVs : 0235 0688 32453 73796 67858
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SUSD2
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Disorders
/ Diseasesfor SUSD2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SUSD2 for disorders About GeneDecksing 1 disease for SUSD2 : About MalaCards neuronitis Human Genome Epidemiology (HuGE) Navigator: SUSD2 (1 document)Export disorders for SUSD2 gene to outside databases
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Publicationsfor SUSD2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SUSD2 gene integrated from 9 sources : (articles sorted by number of sources associating them with SUSD2) Utopia : connect your pdf to the dynamic world of online information
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952) 1 , 2 Liu T.... Smith R.D. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) The DNA sequence of human chromosome 22. (PubMed id 10591208) 1 , 2 Dunham I....O'Brien K.P. (1999) Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218) 2 Chen R.... Zou H. (2009) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931) 1 Ewing R.M.... Figeys D. (2007) Proteomic characterization of the human cortical neuronal cell line HCN-2. (PubMed id 14615026) 9 Peyrl A....Lubec G. (2003)
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External Searches for SUSD2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SUSD2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SUSD2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SUSD2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SUSD2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SUSD2 gene: Search GeneIP for patents involving SUSD2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SUSD2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SUSD2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SUSD2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SUSD2 OriGene Protein Over-expression Lysate for SUSD2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SUSD2 OriGene 3'-UTR Clone for SUSD2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SUSD2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SUSD2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SUSD2 OriGene Custom Protein Services for SUSD2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SUSD2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SUSD2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SUSD2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SUSD2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SUSD2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SUSD2
Search Tocris compounds for SUSD2
SUSD2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUSD2
Search ThermoFisher Antibodies for SUSD2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SUSD2
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Aliases for SUSD2
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Disorders / Diseases for SUSD2
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Drugs / Compounds for SUSD2
Expression for SUSD2
Function for SUSD2
Genomic Views for SUSD2
Intellectual Property for SUSD2
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Pathways / Interactions for SUSD2
Products for SUSD2
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Summaries for SUSD2
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