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Aliases for SUSD2 Gene

Aliases for SUSD2 Gene

  • Sushi Domain Containing 2 2 3
  • Sushi Domain (SCR Repeat) Containing 3
  • Sushi Domain-Containing Protein 2 3
  • BK65A6.2 3

External Ids for SUSD2 Gene

Summaries for SUSD2 Gene

GeneCards Summary for SUSD2 Gene

SUSD2 (Sushi Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include scavenger receptor activity and polysaccharide binding. An important paralog of this gene is MUC4.

UniProtKB/Swiss-Prot for SUSD2 Gene

  • May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUSD2 Gene

Genomics for SUSD2 Gene

Genomic Location for SUSD2 Gene

Start:
24,181,259 bp from pter
End:
24,189,110 bp from pter
Size:
7,852 bases
Orientation:
Plus strand

Genomic View for SUSD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUSD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUSD2 Gene

Regulatory Elements for SUSD2 Gene

Proteins for SUSD2 Gene

  • Protein details for SUSD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGT4-SUSD2_HUMAN
    Recommended name:
    Sushi domain-containing protein 2
    Protein Accession:
    Q9UGT4
    Secondary Accessions:
    • Q9H5Y6

    Protein attributes for SUSD2 Gene

    Size:
    822 amino acids
    Molecular mass:
    90208 Da
    Quaternary structure:
    • Interacts with LGALS1; leads to an increased amount of LGALS1 on the cell surface (PubMed:23131994). Interacts with C10ORF99; the interaction is direct (PubMed:25351403).
    SequenceCaution:
    • Sequence=BAB15481.1; Type=Frameshift; Positions=165; Evidence={ECO:0000305};

neXtProt entry for SUSD2 Gene

Proteomics data for SUSD2 Gene at MOPED

Post-translational modifications for SUSD2 Gene

  • Glycosylation at Asn162, Asn177, Asn494, and Asn522

Other Protein References for SUSD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SUSD2 Gene

Domains for SUSD2 Gene

UniProtKB/Swiss-Prot:

SUSD2_HUMAN
Domain:
  • Contains 1 AMOP domain.:
    • Q9UGT4
  • Contains 1 SMB (somatomedin-B) domain.:
    • Q9UGT4
  • Contains 1 Sushi (CCP/SCR) domain.:
    • Q9UGT4
  • Contains 1 VWFD domain.:
    • Q9UGT4
genes like me logo Genes that share domains with SUSD2: view

No data available for Gene Families for SUSD2 Gene

Function for SUSD2 Gene

Molecular function for SUSD2 Gene

UniProtKB/Swiss-Prot Function: May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994).

Gene Ontology (GO) - Molecular Function for SUSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding IPI 23131994
GO:0030247 polysaccharide binding IEA --
genes like me logo Genes that share ontologies with SUSD2: view
genes like me logo Genes that share phenotypes with SUSD2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SUSD2 Gene

Localization for SUSD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUSD2 Gene

Cell membrane; Single-pass type I membrane protein. Note=SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells. {ECO:0000269 PubMed:23131994}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUSD2 Gene COMPARTMENTS Subcellular localization image for SUSD2 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SUSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23131994
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SUSD2: view

Pathways for SUSD2 Gene

SuperPathways for SUSD2 Gene

No Data Available

Interacting Proteins for SUSD2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000351075%0d%0a9606.ENSP00000215909%0d%0a9606.ENSP00000259253%0d%0a
Selected Interacting proteins: Q9UGT4-SUSD2_HUMAN ENSP00000351075 for SUSD2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for SUSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006955 immune response IEA --
GO:0051782 negative regulation of cell division IDA 25351403
GO:1902807 negative regulation of cell cycle G1/S phase transition IDA 25351403
genes like me logo Genes that share ontologies with SUSD2: view

No data available for Pathways by source for SUSD2 Gene

Transcripts for SUSD2 Gene

mRNA/cDNA for SUSD2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(99) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SUSD2 Gene

Sushi domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUSD2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: -
SP2:
SP3:

Relevant External Links for SUSD2 Gene

GeneLoc Exon Structure for
SUSD2
ECgene alternative splicing isoforms for
SUSD2

Expression for SUSD2 Gene

mRNA expression in normal human tissues for SUSD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUSD2 Gene

This gene is overexpressed in Lung (7.1), Artery - Tibial (5.6), and Artery - Coronary (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUSD2 Gene

SOURCE GeneReport for Unigene cluster for SUSD2 Gene Hs.131819

mRNA Expression by UniProt/SwissProt for SUSD2 Gene

Q9UGT4-SUSD2_HUMAN
Tissue specificity: Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in colon; down-regulated in colon cancer tisues (PubMed:25351403).
genes like me logo Genes that share expressions with SUSD2: view

Orthologs for SUSD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUSD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUSD2 36
  • 98.82 (n)
  • 98.65 (a)
SUSD2 37
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUSD2 36
  • 81.97 (n)
  • 77.49 (a)
SUSD2 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUSD2 36
  • 82.07 (n)
  • 77.83 (a)
SUSD2 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Susd2 36
  • 77.42 (n)
  • 76.71 (a)
Susd2 16
Susd2 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUSD2 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUSD2 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Susd2 36
  • 76.82 (n)
  • 76.64 (a)
chicken
(Gallus gallus)
Aves SUSD2 36
  • 59.67 (n)
  • 56.56 (a)
SUSD2 37
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC793335 36
  • 55.99 (n)
  • 51.13 (a)
SUSD2 37
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000550 36
  • 48.14 (n)
  • 32.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31004 36
  • 46.51 (n)
  • 32.87 (a)
CG31004 37
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_K03H1.5 36
  • 41.15 (n)
  • 33.44 (a)
F54D1.6 37
  • 10 (a)
ManyToMany
K03H1.5 37
  • 13 (a)
ManyToMany
R09E10.5 37
  • 11 (a)
ManyToMany
Species with no ortholog for SUSD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SUSD2 Gene

ENSEMBL:
Gene Tree for SUSD2 (if available)
TreeFam:
Gene Tree for SUSD2 (if available)

Paralogs for SUSD2 Gene

Paralogs for SUSD2 Gene

Pseudogenes.org Pseudogenes for SUSD2 Gene

genes like me logo Genes that share paralogs with SUSD2: view

Variants for SUSD2 Gene

Sequence variations from dbSNP and Humsavar for SUSD2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs399140 -- 24,183,251(+) CAGAC(A/G/T)CCAGT missense, reference
rs1985047 -- 24,184,413(-) CCCTC(C/G)TCAAC intron-variant
rs1985494 -- 24,184,726(-) CCTTC(A/G)AGGCC intron-variant
rs2070469 -- 24,186,771(+) GTTAA(A/G)GATGC intron-variant
rs2070470 -- 24,187,911(+) GTGTG(C/T)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUSD2 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
nsv914599 CNV Gain 21882294
nsv914628 CNV Loss 21882294
nsv914629 CNV Gain 21882294
nsv834157 CNV Gain 17160897
nsv483072 CNV Loss 15286789
nsv508730 CNV Insertion 20534489
nsv914630 CNV Loss 21882294
nsv834158 CNV Gain 17160897
nsv528842 CNV Loss 19592680
nsv914631 CNV Loss 21882294
nsv914632 CNV Loss 21882294
nsv9881 CNV Loss 18304495
esv21680 CNV Loss 19812545

Relevant External Links for SUSD2 Gene

HapMap Linkage Disequilibrium report
SUSD2

Disorders for SUSD2 Gene

Relevant External Links for SUSD2

Human Genome Epidemiology (HuGE) Navigator
SUSD2
genes like me logo Genes that share disorders with SUSD2: view

No data available for UniProtKB/Swiss-Prot for SUSD2 Gene

Publications for SUSD2 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4

Products for SUSD2 Gene

Sources for SUSD2 Gene

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