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Aliases for SUSD1 Gene

Aliases for SUSD1 Gene

  • Sushi Domain Containing 1 2 3 5

External Ids for SUSD1 Gene

Previous GeneCards Identifiers for SUSD1 Gene

  • GC09M110182
  • GC09M111882
  • GC09M113842
  • GC09M114803
  • GC09M084401

Summaries for SUSD1 Gene

GeneCards Summary for SUSD1 Gene

SUSD1 (Sushi Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUSD1 Gene

Genomics for SUSD1 Gene

Regulatory Elements for SUSD1 Gene

Promoters for SUSD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUSD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUSD1 Gene

Chromosome:
9
Start:
112,040,781 bp from pter
End:
112,175,520 bp from pter
Size:
134,740 bases
Orientation:
Minus strand

Genomic View for SUSD1 Gene

Genes around SUSD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUSD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUSD1 Gene

Proteins for SUSD1 Gene

  • Protein details for SUSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWL2-SUSD1_HUMAN
    Recommended name:
    Sushi domain-containing protein 1
    Protein Accession:
    Q6UWL2
    Secondary Accessions:
    • A1A4C5
    • A8KA03
    • Q5T8V6
    • Q5T8V7
    • Q6P9G7
    • Q8WU83
    • Q96DM9
    • Q9H6V2
    • Q9NTA7

    Protein attributes for SUSD1 Gene

    Size:
    747 amino acids
    Molecular mass:
    82710 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15149.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71259.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12348.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95300.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SUSD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUSD1 Gene

Proteomics data for SUSD1 Gene at MOPED

Post-translational modifications for SUSD1 Gene

  • Ubiquitination at Lys 686
  • Glycosylation at Asn 87, Asn 112, Asn 193, Asn 253, Asn 308, Asn 348, Asn 367, and Asn 563
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SUSD1 Gene

Domains & Families for SUSD1 Gene

Gene Families for SUSD1 Gene

Suggested Antigen Peptide Sequences for SUSD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UWL2

UniProtKB/Swiss-Prot:

SUSD1_HUMAN :
  • Contains 3 EGF-like domains.
Domain:
  • Contains 3 EGF-like domains.
  • Contains 2 Sushi (CCP/SCR) domains.
genes like me logo Genes that share domains with SUSD1: view

Function for SUSD1 Gene

Phenotypes for SUSD1 Gene

genes like me logo Genes that share phenotypes with SUSD1: view

Animal Model Products

CRISPR Products

miRNA for SUSD1 Gene

miRTarBase miRNAs that target SUSD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUSD1 Gene

Localization for SUSD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUSD1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUSD1 Gene COMPARTMENTS Subcellular localization image for SUSD1 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SUSD1 Gene

Pathways & Interactions for SUSD1 Gene

SuperPathways for SUSD1 Gene

No Data Available

Interacting Proteins for SUSD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363388%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000275493%0d%0a
Selected Interacting proteins: ENSP00000363388 Q6UWL2-SUSD1_HUMAN for SUSD1 Gene via STRING I2D MINT

Gene Ontology (GO) - Biological Process for SUSD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SUSD1 Gene

Drugs & Compounds for SUSD1 Gene

No Compound Related Data Available

Transcripts for SUSD1 Gene

Unigene Clusters for SUSD1 Gene

Sushi domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUSD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6:
SP7: - -

Relevant External Links for SUSD1 Gene

GeneLoc Exon Structure for
SUSD1
ECgene alternative splicing isoforms for
SUSD1

Expression for SUSD1 Gene

mRNA expression in normal human tissues for SUSD1 Gene

mRNA differential expression in normal tissues according to GTEx for SUSD1 Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for SUSD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (48.1) and Platelet (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUSD1 Gene



SOURCE GeneReport for Unigene cluster for SUSD1 Gene Hs.494827

genes like me logo Genes that share expression patterns with SUSD1: view

Protein tissue co-expression partners for SUSD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SUSD1 Gene

Orthologs for SUSD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUSD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUSD1 35
  • 85.5 (n)
  • 80.72 (a)
SUSD1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUSD1 35
  • 84.39 (n)
  • 80.41 (a)
SUSD1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Susd1 35
  • 80.95 (n)
  • 74.93 (a)
Susd1 16
Susd1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUSD1 35
  • 94.42 (n)
  • 93.51 (a)
SUSD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Susd1 35
  • 76.24 (n)
  • 67.09 (a)
oppossum
(Monodelphis domestica)
Mammalia SUSD1 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves SUSD1 35
  • 58.67 (n)
  • 50.82 (a)
SUSD1 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUSD1 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75573 35
susd1 35
  • 49.36 (n)
  • 34.9 (a)
zebrafish
(Danio rerio)
Actinopterygii SUSD1 (1 of 3) 36
  • 33 (a)
OneToMany
SUSD1 (2 of 3) 36
  • 33 (a)
OneToMany
SUSD1 (3 of 3) 36
  • 29 (a)
OneToMany
Species with no ortholog for SUSD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUSD1 Gene

ENSEMBL:
Gene Tree for SUSD1 (if available)
TreeFam:
Gene Tree for SUSD1 (if available)

Paralogs for SUSD1 Gene

(2) SIMAP similar genes for SUSD1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SUSD1: view

No data available for Paralogs for SUSD1 Gene

Variants for SUSD1 Gene

Sequence variations from dbSNP and Humsavar for SUSD1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs17855713 - 112,078,719(+) CAAAT(G/T)TGGAA intron-variant, nc-transcript-variant, reference, missense
rs17829458 - 112,142,425(+) AACCT(C/G)GCTGC nc-transcript-variant, reference, missense
rs700097 -- 112,146,879(+) gatcc(C/T)ccagc intron-variant
rs700098 -- 112,144,851(-) TATAC(C/T)TGCTG intron-variant
rs700100 -- 112,129,862(-) ATATC(A/G)TAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUSD1 Gene

Variant ID Type Subtype PubMed ID
nsv893731 CNV Gain 21882294
esv2555427 CNV Insertion 19546169
esv268057 CNV Insertion 20981092
esv272517 CNV Insertion 20981092
esv1083675 CNV Insertion 17803354
esv2552622 CNV Deletion 19546169
esv2180224 CNV Deletion 18987734
esv2738945 CNV Deletion 23290073
esv2675703 CNV Deletion 23128226
nsv415911 CNV Loss 16902084

Variation tolerance for SUSD1 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUSD1 Gene

HapMap Linkage Disequilibrium report
SUSD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUSD1 Gene

Disorders for SUSD1 Gene

Relevant External Links for SUSD1

Genetic Association Database (GAD)
SUSD1
Human Genome Epidemiology (HuGE) Navigator
SUSD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUSD1

No disorders were found for SUSD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUSD1 Gene

Publications for SUSD1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PMID: 23650146) Tang W. … Smith N.L. (Genet. Epidemiol. 2013) 3
  4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for SUSD1 Gene

Sources for SUSD1 Gene

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