SURF6 Gene
protein-coding GIFtS: 46
GCID: GC09M136197
|
|
surfeit 6
| |
Aliases
for SURF6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Surfeit 61 2 | | RRP141 2 | | FLJ303221 | | Surfeit Locus Protein 62 | | SURF-63 |
Export aliases for SURF6 gene to outside databasesPrevious GC identifers: GC09M127287 GC09M127754 GC09M129551 GC09M131473 GC09M133227 GC09M135187 GC09M105697 |
Summaries
for SURF6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SURF6:
This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequencesimilarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encodedprotein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs,which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based oncharacteristics determined in mouse. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SURF6_HUMAN, O75683Function: Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolarconstitutive protein involved in ribosomal biosynthesis or assembly (By similarity)
Gene Wiki entry for SURF6
|
Genomic Views
for SURF6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_035014.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SURF6 gene promoter:
ER-alpha HTF Pax-2 Pax-2a FOXL1 PPAR-gamma1 Pax-2b Chx10 Sox9 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SURF6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SURF6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.2 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q33-q34SURF6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M136197: view genomic region
(about GC identifiers)
Start:
|
136,197,552 bp from pter |
End:
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136,203,235 bp from pter |
Size:
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5,684 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr9-,PATCHES 136,201,044-136,206,538 |
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Proteins
for SURF6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SURF6_HUMAN, O75683 (See
protein sequence)Recommended Name: Surfeit locus protein 6 Size: 361 amino acids; 41450 Da
Subcellular location: Nucleus, nucleoplasm (By similarity). Nucleus, nucleolus (By similarity). Note=Granular componentof the nucleolus (By similarity)
Secondary accessions: Q5T8U1 Q9BRK9 Q9BTZ5 Q9UK24Explore the universe of human proteins at neXtProt for SURF6: NX_O75683
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75683
SURF6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006744.2
ENSEMBL proteins: ENSP00000361092
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SURF6 for ontologies About GeneDecksing
SURF6 Antibody Products:
Assay Products for SURF6: |
Protein
Domains /
Families
for SURF6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SURF6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O75683ProtoNet protein and cluster: O75683 1 Blocks protein family: IPB007019 Surfeit locus protein 6
UniProtKB/Swiss-Prot: SURF6_HUMAN, O75683Similarity: Belongs to the SURF6 family |
Function
for SURF6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SURF6_HUMAN, O75683Function: Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolarconstitutive protein involved in ribosomal biosynthesis or assembly (By similarity) Genatlas biochemistry entry for SURF6:surfeit 6 protein (see SURF@),located in nucleolus,ubiquitously expressed
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SURF6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SURF6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SURF6 for ontologies About GeneDecksing
|
Pathways & Interactions
for SURF6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SURF6
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for SURF6 (O756833 ENSP000003610924) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042254 | ribosome biogenesis |
IEA | -- |
SURF6 for ontologies About GeneDecksing
|
Drugs & Compounds
for SURF6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SURF6
Search CenterWatch for drugs/clinical trials and news about SURF6
|
Transcripts
for SURF6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SURF6 gene: NM_006753.4 Unigene Cluster for SURF6: Surfeit 6 Hs.274430 [show with all ESTs]Unigene Representative Sequence: NM_0067532 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372022(uc004cdb.4) ENST00000468290
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SURF6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SURF6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SURF6 (NM_006753) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SURF6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SURF6 |
Additional cDNA sequence: AK054884.1 BC003001.1 BC006197.2 BC014878.1 11 DOTS entries: DT.100795328 DT.313301 DT.100795320 DT.100795323 DT.99956444 DT.100759030 DT.100761410 DT.100795321 DT.91728468 DT.100795330 DT.121151797 24/432 AceView cDNA sequences (see all 432): BC006197 BQ685121 BQ212228 BM684392 AI421031 CB122347 AI653533 AA496954 T12599 CR626491 AA459247 BQ422401 X85178 NM_006753 BM911990 BQ070993 BU845334 AA631627 BM800831 AI445134 BX955496 NM_181491 R50680 AI085033
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for SURF6 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 |
|---|
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for SURF6
|
Expression
for SURF6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SURF6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAGTTGGGT
About this image
See SURF6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SURF6
SOURCE GeneReport for Unigene cluster: Hs.274430
SABiosciences Custom PCR Arrays for SURF6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SURF6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SURF6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SURF6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SURF6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SURF6 |
Orthologs
for SURF6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SURF6 gene from 9/31 species (see all 31) About this table
ENSEMBL Gene Tree for SURF6 (if available)
TreeFam Gene Tree for SURF6 (if available) |
Paralogs
for SURF6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SURF6 gene
SURF6 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for SURF6
PGOHUM00000249262 PGOHUM00000233969
|
Genomic Variants
for SURF6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SURF6 (136197552 - 136203235 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SURF6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SURF6 |
|
Disorders
/ Diseases
for SURF6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SURF6 for disorders About MalaCards
SURF6 for disorders About GeneDecksing
OMIM gene information: 185642
OMIM disorders: --
Export disorders for SURF6 gene to outside databases
|
Publications
for SURF6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SURF6 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with SURF6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus. (PubMed id 10675619)1, 2, 9 Magoulas C. and Fried M. (2000)
- Identification of an evolutionary conserved SURF-6 do main in a family of nucleolar proteins extending from human to yeast. (PubMed id 15629442)1, 3 Polzikov M....Magoulas C. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts. (PubMed id 11891058)1, 2 Angiolillo A....Pietropaolo C. (2002)
- The human Surfeit locus. (PubMed id 9740673)1, 3 Duhig T.... Fried M. (1998)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
|
External Searches for SURF6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SURF6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SURF6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SURF6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SURF6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SURF6 gene:
Search GeneIP for patents involving SURF6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SURF6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SURF6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SURF6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SURF6 | | | OriGene Protein Over-expression Lysate for SURF6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SURF6 | | OriGene 3'-UTR Clone for SURF6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SURF6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SURF6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SURF6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SURF6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SURF6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SURF6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SURF6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SURF6 |
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| | | | Search Tocris compounds for SURF6 |
| |  |  |  |  | | | | |
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 | | | SURF6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SURF6 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SURF6 |
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