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Aliases for SURF6 Gene

Aliases for SURF6 Gene

  • Surfeit 6 2 3 5
  • Surfeit Locus Protein 6 2
  • SURF-6 4
  • RRP14 3

External Ids for SURF6 Gene

Previous GeneCards Identifiers for SURF6 Gene

  • GC09M127287
  • GC09M127754
  • GC09M129551
  • GC09M131473
  • GC09M133227
  • GC09M135187
  • GC09M136197
  • GC09M105697

Summaries for SURF6 Gene

Entrez Gene Summary for SURF6 Gene

  • This gene encodes a conserved protein that is localized to the nucleolus. The encoded protein may function as a nucleolar-matrix protein with nucleic acid-binding properties. There is a pseudogene for this gene on chromosome Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for SURF6 Gene

SURF6 (Surfeit 6) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and RNA binding.

UniProtKB/Swiss-Prot for SURF6 Gene

  • Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).

Gene Wiki entry for SURF6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SURF6 Gene

Genomics for SURF6 Gene

Regulatory Elements for SURF6 Gene

Enhancers for SURF6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SURF6 on UCSC Golden Path with GeneCards custom track

Promoters for SURF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SURF6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SURF6 Gene

Chromosome:
9
Start:
133,328,774 bp from pter
End:
133,336,398 bp from pter
Size:
7,625 bases
Orientation:
Minus strand

Genomic View for SURF6 Gene

Genes around SURF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SURF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SURF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SURF6 Gene

Proteins for SURF6 Gene

  • Protein details for SURF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75683-SURF6_HUMAN
    Recommended name:
    Surfeit locus protein 6
    Protein Accession:
    O75683
    Secondary Accessions:
    • Q5T8U1
    • Q9BRK9
    • Q9BTZ5
    • Q9UK24

    Protein attributes for SURF6 Gene

    Size:
    361 amino acids
    Molecular mass:
    41450 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SURF6 Gene

Proteomics data for SURF6 Gene at MOPED

Post-translational modifications for SURF6 Gene

  • Ubiquitination at Lys 7
  • Modification sites at PhosphoSitePlus

Other Protein References for SURF6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SURF6 Gene

Domains & Families for SURF6 Gene

Protein Domains for SURF6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SURF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75683

UniProtKB/Swiss-Prot:

SURF6_HUMAN :
  • Belongs to the SURF6 family.
Family:
  • Belongs to the SURF6 family.
genes like me logo Genes that share domains with SURF6: view

No data available for Gene Families for SURF6 Gene

Function for SURF6 Gene

Molecular function for SURF6 Gene

GENATLAS Biochemistry:
surfeit 6 protein (see SURF@),located in nucleolus,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).

Gene Ontology (GO) - Molecular Function for SURF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SURF6: view

Phenotypes for SURF6 Gene

GenomeRNAi human phenotypes for SURF6:
genes like me logo Genes that share phenotypes with SURF6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SURF6 Gene

Localization for SURF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SURF6 Gene

Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Granular component of the nucleolus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SURF6 Gene COMPARTMENTS Subcellular localization image for SURF6 gene
Compartment Confidence
nucleus 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SURF6 Gene

Pathways & Interactions for SURF6 Gene

SuperPathways for SURF6 Gene

No Data Available

Interacting Proteins for SURF6 Gene

Gene Ontology (GO) - Biological Process for SURF6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SURF6 Gene

Drugs & Compounds for SURF6 Gene

No Compound Related Data Available

Transcripts for SURF6 Gene

mRNA/cDNA for SURF6 Gene

Unigene Clusters for SURF6 Gene

Surfeit 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SURF6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4
SP1:
SP2: -

Relevant External Links for SURF6 Gene

GeneLoc Exon Structure for
SURF6
ECgene alternative splicing isoforms for
SURF6

Expression for SURF6 Gene

mRNA expression in normal human tissues for SURF6 Gene

Protein differential expression in normal tissues from HIPED for SURF6 Gene

This gene is overexpressed in Lung (25.5) and Peripheral blood mononuclear cells (23.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SURF6 Gene



SOURCE GeneReport for Unigene cluster for SURF6 Gene Hs.274430

genes like me logo Genes that share expression patterns with SURF6: view

Protein tissue co-expression partners for SURF6 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SURF6 Gene

Orthologs for SURF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SURF6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SURF6 35
  • 79.83 (n)
  • 77.56 (a)
SURF6 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SURF6 35
  • 77.65 (n)
  • 73.58 (a)
-- 36
  • 68 (a)
OneToMany
SURF6 36
  • 73 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Surf6 35
  • 77.5 (n)
  • 74.01 (a)
Surf6 16
Surf6 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SURF6 35
  • 99.45 (n)
  • 99.45 (a)
SURF6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Surf6 35
  • 77.71 (n)
  • 74.5 (a)
oppossum
(Monodelphis domestica)
Mammalia SURF6 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SURF6 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves SURF6 35
  • 56.85 (n)
  • 48.98 (a)
SURF6 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.415 35
surf6 35
  • 54.53 (n)
  • 48.96 (a)
African clawed frog
(Xenopus laevis)
Amphibia surf6 35
zebrafish
(Danio rerio)
Actinopterygii surf6 35
  • 51.67 (n)
  • 43.27 (a)
zgc64008 35
surf6 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Surf6 36
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK546.14 36
  • 18 (a)
OneToOne
Species with no ortholog for SURF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SURF6 Gene

ENSEMBL:
Gene Tree for SURF6 (if available)
TreeFam:
Gene Tree for SURF6 (if available)

Paralogs for SURF6 Gene

Pseudogenes.org Pseudogenes for SURF6 Gene

genes like me logo Genes that share paralogs with SURF6: view

No data available for Paralogs for SURF6 Gene

Variants for SURF6 Gene

Sequence variations from dbSNP and Humsavar for SURF6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs886090 - 133,332,667(+) CGCCC(A/G)CAGCT nc-transcript-variant, reference, synonymous-codon, missense
rs886089 - 133,332,630(+) CCTCC(A/C/G)TGGCC nc-transcript-variant, reference, missense
rs1800867 - 133,332,023(-) GCGCA(C/T)GGCCG nc-transcript-variant, reference, missense, utr-variant-3-prime
rs34657219 - 133,332,576(+) GCTCC(C/T)GCGGC nc-transcript-variant, reference, missense
rs35316446 - 133,332,553(+) CTTAT(G/T)GAAGA nc-transcript-variant, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SURF6 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv894057 CNV Gain 21882294
dgv8325n71 CNV Loss 21882294
nsv894076 CNV Loss 21882294
nsv894079 CNV Loss 21882294
nsv894080 CNV Loss 21882294

Variation tolerance for SURF6 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.58; 91.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SURF6 Gene

Disorders for SURF6 Gene

Relevant External Links for SURF6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SURF6

No disorders were found for SURF6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SURF6 Gene

Publications for SURF6 Gene

  1. Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus. (PMID: 10675619) Magoulas C. … Fried M. (Gene 2000) 3 4 23 67
  2. Identification of an evolutionary conserved SURF-6 domain in a family of nucleolar proteins extending from human to yeast. (PMID: 15629442) Polzikov M. … Magoulas C. (Biochem. Biophys. Res. Commun. 2005) 2 3
  3. The human Surfeit locus. (PMID: 9740673) Duhig T. … Fried M. (Genomics 1998) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for SURF6 Gene

Sources for SURF6 Gene

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