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Aliases for SURF6 Gene

Aliases for SURF6 Gene

  • Surfeit 6 2 3
  • Surfeit Locus Protein 6 2 3
  • SURF-6 4
  • RRP14 3

External Ids for SURF6 Gene

Previous GeneCards Identifiers for SURF6 Gene

  • GC09M127287
  • GC09M127754
  • GC09M129551
  • GC09M131473
  • GC09M133227
  • GC09M135187
  • GC09M136197
  • GC09M105697

Summaries for SURF6 Gene

Entrez Gene Summary for SURF6 Gene

  • This gene encodes a conserved protein that is localized to the nucleolus. The encoded protein may function as a nucleolar-matrix protein with nucleic acid-binding properties. There is a pseudogene for this gene on chromosome Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for SURF6 Gene

SURF6 (Surfeit 6) is a Protein Coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for SURF6 Gene

  • Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).

Gene Wiki entry for SURF6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SURF6 Gene

Genomics for SURF6 Gene

Regulatory Elements for SURF6 Gene

Genomic Location for SURF6 Gene

Start:
133,330,707 bp from pter
End:
133,336,398 bp from pter
Size:
5,692 bases
Orientation:
Minus strand

Genomic View for SURF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SURF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SURF6 Gene

Proteins for SURF6 Gene

  • Protein details for SURF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75683-SURF6_HUMAN
    Recommended name:
    Surfeit locus protein 6
    Protein Accession:
    O75683
    Secondary Accessions:
    • Q5T8U1
    • Q9BRK9
    • Q9BTZ5
    • Q9UK24

    Protein attributes for SURF6 Gene

    Size:
    361 amino acids
    Molecular mass:
    41450 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SURF6 Gene

Proteomics data for SURF6 Gene at MOPED

Post-translational modifications for SURF6 Gene

  • Ubiquitination at Lys7
  • Modification sites at PhosphoSitePlus

Other Protein References for SURF6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SURF6 Gene

Domains for SURF6 Gene

Protein Domains for SURF6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SURF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75683

UniProtKB/Swiss-Prot:

SURF6_HUMAN :
  • O75683
Family:
  • Belongs to the SURF6 family.
genes like me logo Genes that share domains with SURF6: view

No data available for Gene Families for SURF6 Gene

Function for SURF6 Gene

Molecular function for SURF6 Gene

GENATLAS Biochemistry: surfeit 6 protein (see SURF@),located in nucleolus,ubiquitously expressed
UniProtKB/Swiss-Prot Function: Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).

Gene Ontology (GO) - Molecular Function for SURF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0003723 RNA binding ISS --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SURF6: view

miRNA for SURF6 Gene

miRTarBase miRNAs that target SURF6

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SURF6 Gene

Localization for SURF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SURF6 Gene

Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Granular component of the nucleolus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SURF6 Gene COMPARTMENTS Subcellular localization image for SURF6 gene
Compartment Confidence
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SURF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001652 granular component ISS --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus TAS 10675619
genes like me logo Genes that share ontologies with SURF6: view

Pathways for SURF6 Gene

SuperPathways for SURF6 Gene

No Data Available

Interacting Proteins for SURF6 Gene

Gene Ontology (GO) - Biological Process for SURF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with SURF6: view

No data available for Pathways by source for SURF6 Gene

Transcripts for SURF6 Gene

mRNA/cDNA for SURF6 Gene

Unigene Clusters for SURF6 Gene

Surfeit 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SURF6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4
SP1:
SP2: -

Relevant External Links for SURF6 Gene

GeneLoc Exon Structure for
SURF6
ECgene alternative splicing isoforms for
SURF6

Expression for SURF6 Gene

mRNA expression in normal human tissues for SURF6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SURF6 Gene

SOURCE GeneReport for Unigene cluster for SURF6 Gene Hs.274430

genes like me logo Genes that share expressions with SURF6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SURF6 Gene

Orthologs for SURF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SURF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SURF6 35
  • 99.45 (n)
  • 99.45 (a)
SURF6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SURF6 35
  • 79.83 (n)
  • 77.56 (a)
SURF6 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 68 (a)
OneToMany
SURF6 35
  • 77.65 (n)
  • 73.58 (a)
SURF6 36
  • 73 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Surf6 35
  • 77.5 (n)
  • 74.01 (a)
Surf6 16
Surf6 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SURF6 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SURF6 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Surf6 35
  • 77.71 (n)
  • 74.5 (a)
chicken
(Gallus gallus)
Aves SURF6 35
  • 56.85 (n)
  • 48.98 (a)
SURF6 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia surf6 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.415 35
surf6 35
  • 54.53 (n)
  • 48.96 (a)
zebrafish
(Danio rerio)
Actinopterygii surf6 35
  • 51.67 (n)
  • 43.27 (a)
surf6 36
  • 44 (a)
OneToOne
zgc64008 35
fruit fly
(Drosophila melanogaster)
Insecta Surf6 36
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK546.14 36
  • 18 (a)
OneToOne
Species with no ortholog for SURF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SURF6 Gene

ENSEMBL:
Gene Tree for SURF6 (if available)
TreeFam:
Gene Tree for SURF6 (if available)

Paralogs for SURF6 Gene

Pseudogenes.org Pseudogenes for SURF6 Gene

genes like me logo Genes that share paralogs with SURF6: view

No data available for Paralogs for SURF6 Gene

Variants for SURF6 Gene

Sequence variations from dbSNP and Humsavar for SURF6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2491 -- 133,331,135(+) ACTTT(G/T)TATCT utr-variant-3-prime, nc-transcript-variant
rs12335 -- 133,330,998(+) GTCTC(A/G)TAACC utr-variant-3-prime, nc-transcript-variant
rs120858 -- 133,333,974(+) TCCAG(A/G)ACAGG intron-variant
rs511914 -- 133,336,391(+) GCCTC(A/T)ATCAC upstream-variant-2KB
rs551154 -- 133,330,442(+) tgttg(G/T)ccagg downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SURF6 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv894057 CNV Gain 21882294
dgv8325n71 CNV Loss 21882294
nsv894076 CNV Loss 21882294
nsv894079 CNV Loss 21882294
nsv894080 CNV Loss 21882294

Relevant External Links for SURF6 Gene

HapMap Linkage Disequilibrium report
SURF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SURF6 Gene

Disorders for SURF6 Gene

No disorders were found for SURF6 Gene.

No data available for UniProtKB/Swiss-Prot for SURF6 Gene

Publications for SURF6 Gene

  1. Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus. (PMID: 10675619) Magoulas C. … Fried M. (Gene 2000) 3 4 23
  2. The human Surfeit locus. (PMID: 9740673) Duhig T. … Fried M. (Genomics 1998) 2 3
  3. The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts. (PMID: 11891058) Angiolillo A. … Pietropaolo C. (Gene 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of an evolutionary conserved SURF-6 domain in a family of nucleolar proteins extending from human to yeast. (PMID: 15629442) Polzikov M. … Magoulas C. (Biochem. Biophys. Res. Commun. 2005) 2 3

Products for SURF6 Gene

Sources for SURF6 Gene

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