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SURF4 Gene

protein-coding   GIFtS: 53
GCID: GC09M136228

Surfeit 4

  Search for SURF4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Surfeit 41 2
Surface 4 Integral Membrane Protein1 2
Surfeit Locus Protein 41 2
ERV292
SURF-43

External Ids:    HGNC: 114761   Entrez Gene: 68362   Ensembl: ENSG000001482487   OMIM: 1856605   UniProtKB: O152603   

Export aliases for SURF4 gene to outside databases

Previous GC identifers: GC09M127318 GC09M127785 GC09M129582 GC09M131504 GC09M133257 GC09M135206 GC09M135218 GC09M105728


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SURF4 Gene:
This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes
that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that
interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in
reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat
protein I to the cytosol. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Jul
2013)

GeneCards Summary for SURF4 Gene:
SURF4 (surfeit 4) is a protein-coding gene.

UniProtKB/Swiss-Prot: SURF4_HUMAN, O15260
Function: May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate
compartment and of the Golgi

Gene Wiki entry for SURF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SURF4 gene promoter:
         AML1a   Lmo2   STAT5A   Nkx2-5   C/EBPalpha   HEN1   CHOP-10   ZID   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSURF4 promoter sequence
   Search Chromatin IP Primers for SURF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SURF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.2   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q33-q34

SURF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SURF4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M136228:  view genomic region     (about GC identifiers)

Start:
136,228,325 bp from pter      End:
136,242,970 bp from pter
Size:
14,646 bases      Orientation:
minus strand

1 alternative location:
Chr9-,NW_003315925 187,558-202,193     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SURF4_HUMAN, O15260 (See protein sequence)
Recommended Name: Surfeit locus protein 4  
Size: 269 amino acids; 30394 Da
Subunit: Found in a complex composed at least of SURF4, TMED2 and TMED10. May interact with LMAN1
Secondary accessions: O60923 Q5T8U6 Q9UNZ0 Q9UNZ1
Alternative splicing: 2 isoforms:  O15260-1   O15260-2   

Explore the universe of human proteins at neXtProt for SURF4: NX_O15260

Explore proteomics data for SURF4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys139
  • Modification sites at PhosphoSitePlus

  • See SURF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001267717.1  NP_001267718.1  NP_001267719.1  NP_001267720.1  NP_001267721.1  NP_001267722.1  NP_149351.1  

    ENSEMBL proteins: 
     ENSP00000361057   ENSP00000419853   ENSP00000361059   ENSP00000446061  

    SURF4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SURF4
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    Novus Biologicals SURF4 Proteins
    Novus Biologicals SURF4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SURF4

     
    Search eBioscience for Proteins for SURF4 

    SURF4 Antibody Products:

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    Search eBioscience for ELISAs for SURF4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002995 Surf4

    Graphical View of Domain Structure for InterPro Entry O15260

    ProtoNet protein and cluster: O15260

    2 Blocks protein domains:
    IPB002995 Surf4 protein
    IPB011592 Surfeit locus 4-related


    UniProtKB/Swiss-Prot: SURF4_HUMAN, O15260
    Domain: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins
    Similarity: Belongs to the SURF4 family


    Find genes that share domains with SURF4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SURF4_HUMAN, O15260
    Function: May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate
    compartment and of the Golgi

         Genatlas biochemistry entry for SURF4:
    surfeit 4 (see SURF@),putative integral membrane protein of the endoplasmic reticulum,30kDa

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18287528
         
    Find genes that share ontologies with SURF4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SURF4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SURF4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SURF4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SURF4

    miRNA
    Products:
        
    miRTarBase miRNAs that target SURF4:
    hsa-mir-93-3p (MIRT038907), hsa-mir-744-5p (MIRT037674), hsa-mir-877-5p (MIRT037305), hsa-mir-34a-5p (MIRT025424), hsa-mir-124-3p (MIRT001831), hsa-mir-193b-3p (MIRT016415), hsa-mir-92a-3p (MIRT049234), hsa-mir-17-5p (MIRT050908)

    Block miRNA regulation of human, mouse, rat SURF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SURF4 (see all 71):
    hsa-miR-607 hsa-miR-1321 hsa-miR-1260b hsa-miR-128 hsa-miR-30d hsa-miR-371-5p hsa-miR-1244 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSURF4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SURF4
    Predesigned siRNA for gene silencing in human, mouse, rat SURF4

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SURF4 (NM_033161)
    Sino Biological Human cDNA Clone for SURF4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SURF4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SURF4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SURF4_HUMAN, O15260: Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi
    intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane
    protein. Note=Cycles between the endoplasmic reticulum and the Golgi
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    plasma membrane3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA15308636
    GO:0016021integral component of membrane IEA--
    GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane IEA--

    Find genes that share ontologies with SURF4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SURF4
    Interactions:

        Search GeneGlobe Interaction Network for SURF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SURF4 (O152601, 3 ENSP000003610574) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMEM173Q86WV61, 3, ENSP000003312884EBI-1044848,EBI-2800345 I2D: score=1 STRING: ENSP00000331288
    SEC61A1P616193, ENSP000002432534I2D: score=4 STRING: ENSP00000243253
    C20orf24Q9BUV83, ENSP000003412134I2D: score=2 STRING: ENSP00000341213
    DDOSTP396563, ENSP000003641884I2D: score=2 STRING: ENSP00000364188
    SERINC3Q135303, ENSP000002551754I2D: score=2 STRING: ENSP00000255175
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007030Golgi organization IMP18287528
    GO:0010638positive regulation of organelle organization IMP18287528
    GO:0032527NOT protein exit from endoplasmic reticulum IMP18287528
    GO:0034498NOT early endosome to Golgi transport IMP18287528

    Find genes that share ontologies with SURF4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SURF4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SURF4 gene (7 alternative transcripts): 
    NM_001280788.1  NM_001280789.1  NM_001280790.1  NM_001280791.1  NM_001280792.1  NM_001280793.1  NM_033161.3  

    Unigene Cluster for SURF4:

    Surfeit 4
    Hs.512465  [show with all ESTs]
    Unigene Representative Sequence: NM_033161
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371989(uc011mda.2 uc010nal.3 uc004cdj.3 uc011mdb.2 uc011mdc.2 uc011mdd.2)
    ENST00000485435 ENST00000465565 ENST00000467910 ENST00000371991 ENST00000371982
    ENST00000545297
    miRNA
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    Block miRNA regulation of human, mouse, rat SURF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SURF4 (see all 71):
    hsa-miR-607 hsa-miR-1321 hsa-miR-1260b hsa-miR-128 hsa-miR-30d hsa-miR-371-5p hsa-miR-1244 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSURF4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SURF4
    Predesigned siRNA for gene silencing in human, mouse, rat SURF4
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SURF4 (NM_033161)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SURF4
    Primer
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    OriGene qPCR primer pairs and template standards for SURF4
    OriGene qSTAR qPCR primer pairs in human, mouse for SURF4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SURF4
      QuantiTect SYBR Green Assays in human, mouse, rat SURF4
      QuantiFast Probe-based Assays in human, mouse, rat SURF4

    Additional mRNA sequence: 

    AF078866.1 AF078867.1 AK026646.1 AK293434.1 AK295435.1 AK299656.1 AK300004.1 AK301737.1 
    AK303309.1 AK310333.1 AK315488.1 AK316480.1 BC018741.1 BC111023.1 BX647961.1 Y14820.1 

    Selected DOTS entries (see all 60):

    DT.100753828  DT.100881736  DT.121151916  DT.100881739  DT.100881723  DT.121152226  DT.70101700  DT.95301849 
    DT.100881734  DT.95276102  DT.100881719  DT.121152066  DT.121152231  DT.100881716  DT.121151967  DT.100881738 
    DT.100881724  DT.95276105  DT.121151697  DT.100881708  DT.100881733  DT.121152095  DT.121151952  DT.95276119 

    Selected AceView cDNA sequences (see all 1147):

    BQ229149 BF569936 BM754084 BC028314 AI476287 CB160300 AI080712 BQ653383 
    CR600443 BQ233098 CA438258 AA373342 T34291 BF882758 CR600613 BM834978 
    AA315450 BX387582 BM726235 BM263854 F10477 AA243701 AW512980 AW440577 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SURF4 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:        -     -     -     -     -     -     -     -           -                       -                 -               
    SP2:                    -     -     -     -     -     -           -                       -                 -               
    SP3:                    -     -     -     -     -     -           -                       -                                 
    SP4:                                -           -     -           -                       -                                 
    SP5:                    -     -     -     -     -     -           -                                                         


    ECgene alternative splicing isoforms for SURF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SURF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGACTGGCT
    SURF4 Expression
    About this image

    SURF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SURF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512465
        Custom PCR Arrays for SURF4
    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat SURF4
    QuantiFast Probe-based Assays in human, mouse, rat SURF4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SURF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SURF4 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Surf41 , 5 surfeit gene 41, 5 90.21(n)1
    99.26(a)1
      2 (19.10 cM)5
    209321  NM_011512.31  NP_035642.11 
     269200405 
    chicken
    (Gallus gallus)
    Aves SURF41 surfeit 4 81.04(n)
    93.31(a)
      374273  NM_204355.1  NP_989686.1 
    lizard
    (Anolis carolinensis)
    Reptilia SURF46
    surfeit 4
    80(a)
    1 ↔ 1
    2(28996709-29017143)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.334202 Xenopus laevis transcribed sequence with strong similarity more 79.4(n)    BU909982.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658062 similar to surfeit 4 80.12(n)   394102  BC056295.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Surf41 , 3 Surfeit 41 59(a)3
    64.41(n)1
    59.77(a)1
      88F13
    418641  NM_169647.31  NP_732016.11 
    worm
    (Caenorhabditis elegans)
    Secernentea sft-41 , 3 sft-41 58(a)
    (best of 2)3
    60.07(n)1
    58.96(a)1
      X(5814578-5815981)3
    1808431  NM_076569.81  NP_508970.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERV29(YGR284C)4
    ERV291
    Protein localized to COPII-coated vesicles, involved more4
    ERV291
    45.56(n)1
    37.08(a)1
      7(1061590-1060658)4
    8532011, 4  NP_011800.31  NP_011800.14 


    ENSEMBL Gene Tree for SURF4 (if available)
    TreeFam Gene Tree for SURF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SURF4 (see all 323)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413355451,2
    --136228606(+) CTGGTA/GCAGAA 1 -- ut310--------
    rs21073681,2
    C,F,A,H--136228609(+) GTGCAG/AAACTG 1 -- ut31 ese312Minor allele frequency- A:0.01EA NA MN NS 1132
    rs413067241,2
    C,F--136228665(+) CCAATC/TAGCCA 1 -- ut312Minor allele frequency- T:0.02WA NA 238
    rs111011,2
    F--136228732(+) TCATAC/TGGCAC 1 -- ut31 ese31Minor allele frequency- T:0.00MN 184
    rs1920537651,2
    --136228749(+) GGAGCA/GAGGTG 1 -- ut310--------
    rs22401721,2
    C,F,H--136228795(+) TGAGAC/TAAGCC 1 -- ut3110Minor allele frequency- T:0.20EA NA NS 2152
    rs1468675341,2
    C--136228836(+) GGAGA-/AGAGAGA 1 -- ut310--------
    rs413099561,2
    C--136228862(+) AGCCAC/TTGCTC 1 -- ut310--------
    rs10597731,2
    C,F,A,H--136228865(-) ATCGAC/G/TCAATG 2 -- ut3130EA MN NA NS WA CSA 4513
    rs1494253011,2
    --136228867(+) TTGCTC/TGATCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SURF4 (136228325 - 136242970 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SURF4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739138CNV Deletion23290073
    nsv894081CNV Loss21882294
    nsv894076CNV Loss21882294
    dgv8325n71CNV Loss21882294
    nsv894080CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SURF4
    DNA2.0 Custom Variant and Variant Library Synthesis for SURF4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 185660    OMIM disorders: --


    Find genes that share disorders with SURF4           About GenesLikeMe

    Genetic Association Database (GAD): SURF4
    Human Genome Epidemiology (HuGE) Navigator: SURF4 (4 documents)

    Export disorders for SURF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SURF4 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with SURF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The surf-4 gene encodes a novel 30 kDa integral membrane protein. (PubMed id 7540914)1, 2, 3 Reeves J.E. and Fried M. (Mol. Membr. Biol. 1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. (PubMed id 18287528)1, 2 Mitrovic S.... Hauri H.-P. (Mol. Biol. Cell 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. (PubMed id 15308636)1, 2 Breuza L....Hauri H.-P. (J. Biol. Chem. 2004)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    8. The human Surfeit locus. (PubMed id 9740673)1, 2 Duhig T.... Fried M. (Genomics 1998)
    9. The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1. (PubMed id 8499913)1, 3 Yon J....Fried M. (Hum. Mol. Genet. 1993)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6836 HGNC: 11476 AceView: SURF1andSURF4 Ensembl:ENSG00000148248 euGenes: HUgn6836
    ECgene: SURF4 H-InvDB: SURF4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SURF4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SURF4 gene:
    Search GeneIP for patents involving SURF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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