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Aliases for SURF4 Gene

Aliases for SURF4 Gene

  • Surfeit 4 2 3 5
  • Surface 4 Integral Membrane Protein 2 3
  • Surfeit Locus Protein 4 2
  • SURF-4 4
  • ERV29 3

External Ids for SURF4 Gene

Previous GeneCards Identifiers for SURF4 Gene

  • GC09M127318
  • GC09M127785
  • GC09M129582
  • GC09M131504
  • GC09M133257
  • GC09M135206
  • GC09M135218
  • GC09M136228
  • GC09M105728

Summaries for SURF4 Gene

Entrez Gene Summary for SURF4 Gene

  • This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for SURF4 Gene

SURF4 (Surfeit 4) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport.

UniProtKB/Swiss-Prot for SURF4 Gene

  • May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.

Gene Wiki entry for SURF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SURF4 Gene

Genomics for SURF4 Gene

Regulatory Elements for SURF4 Gene

Enhancers for SURF4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SURF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SURF4 Gene

133,361,449 bp from pter
133,377,949 bp from pter
16,501 bases
Minus strand

Genomic View for SURF4 Gene

Genes around SURF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SURF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SURF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SURF4 Gene

Proteins for SURF4 Gene

  • Protein details for SURF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Surfeit locus protein 4
    Protein Accession:
    Secondary Accessions:
    • B7Z6A4
    • O60923
    • Q5T8U6
    • Q9UNZ0
    • Q9UNZ1

    Protein attributes for SURF4 Gene

    269 amino acids
    Molecular mass:
    30394 Da
    Quaternary structure:
    • Found in a complex composed at least of SURF4, TMED2 and TMED10. May interact with LMAN1.

    Alternative splice isoforms for SURF4 Gene


neXtProt entry for SURF4 Gene

Proteomics data for SURF4 Gene at MOPED

Post-translational modifications for SURF4 Gene

  • Ubiquitination at Lys 139
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SURF4 Gene

Domains & Families for SURF4 Gene

Protein Domains for SURF4 Gene


Graphical View of Domain Structure for InterPro Entry



  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
  • Belongs to the SURF4 family.
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
  • Belongs to the SURF4 family.
genes like me logo Genes that share domains with SURF4: view

No data available for Gene Families for SURF4 Gene

Function for SURF4 Gene

Molecular function for SURF4 Gene

GENATLAS Biochemistry:
surfeit 4 (see SURF@),putative integral membrane protein of the endoplasmic reticulum,30kDa
UniProtKB/Swiss-Prot Function:
May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.
genes like me logo Genes that share phenotypes with SURF4: view

Animal Model Products

miRNA for SURF4 Gene

miRTarBase miRNAs that target SURF4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SURF4 Gene

Localization for SURF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SURF4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.

Subcellular locations from

Jensen Localization Image for SURF4 Gene COMPARTMENTS Subcellular localization image for SURF4 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SURF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0016021 integral component of membrane IEA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
genes like me logo Genes that share ontologies with SURF4: view

Pathways & Interactions for SURF4 Gene

genes like me logo Genes that share pathways with SURF4: view

Gene Ontology (GO) - Biological Process for SURF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 18287528
GO:0034498 NOT early endosome to Golgi transport IMP 18287528
genes like me logo Genes that share ontologies with SURF4: view

No data available for SIGNOR curated interactions for SURF4 Gene

Drugs & Compounds for SURF4 Gene

No Compound Related Data Available

Transcripts for SURF4 Gene

Unigene Clusters for SURF4 Gene

Surfeit 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SURF4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - -
SP7: -
SP8: - - - - - -
SP10: - - - - - -

Relevant External Links for SURF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SURF4 Gene

mRNA expression in normal human tissues for SURF4 Gene

Protein differential expression in normal tissues from HIPED for SURF4 Gene

This gene is overexpressed in Nasal epithelium (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SURF4 Gene

SOURCE GeneReport for Unigene cluster for SURF4 Gene Hs.512465

genes like me logo Genes that share expression patterns with SURF4: view

Protein tissue co-expression partners for SURF4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SURF4 Gene

Orthologs for SURF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SURF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SURF4 35
  • 91.33 (n)
  • 99.26 (a)
(Canis familiaris)
Mammalia SURF4 35
  • 90.41 (n)
  • 96.9 (a)
SURF4 36
  • 95 (a)
(Mus musculus)
Mammalia Surf4 35
  • 90.21 (n)
  • 99.26 (a)
Surf4 16
Surf4 36
  • 99 (a)
(Pan troglodytes)
Mammalia SURF4 35
  • 99.88 (n)
  • 100 (a)
SURF4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Surf4 35
  • 89.71 (n)
  • 99.26 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
-- 36
  • 92 (a)
-- 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia SURF4 36
  • 97 (a)
(Gallus gallus)
Aves SURF4 35
  • 81.04 (n)
  • 93.31 (a)
SURF4 36
  • 93 (a)
(Anolis carolinensis)
Reptilia SURF4 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76061 35
surf4.2 35
  • 80.42 (n)
  • 91.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33420 35
(Danio rerio)
Actinopterygii surf4 35
  • 79.68 (n)
  • 88.1 (a)
zgc65806 35
surf4l 36
  • 87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Surf4 37
  • 59 (a)
Surf4 35
  • 64.41 (n)
  • 59.77 (a)
Surf4 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001069 35
  • 58.52 (n)
  • 63.16 (a)
(Caenorhabditis elegans)
Secernentea sft-4 37
  • 58 (a)
T02E1.7 37
  • 33 (a)
sft-4 35
  • 60.07 (n)
  • 58.96 (a)
sft-4 36
  • 57 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL340C 35
  • 48.54 (n)
  • 35.36 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03102g 35
  • 46.48 (n)
  • 35.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV29 35
  • 45.56 (n)
  • 37.08 (a)
ERV29 36
  • 29 (a)
ERV29 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3084 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03319 35
  • 50.97 (n)
  • 38.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC970.06 35
  • 45.8 (n)
  • 37.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5467 36
  • 58 (a)
Species with no ortholog for SURF4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SURF4 Gene

Gene Tree for SURF4 (if available)
Gene Tree for SURF4 (if available)

Paralogs for SURF4 Gene

No data available for Paralogs for SURF4 Gene

Variants for SURF4 Gene

Sequence variations from dbSNP and Humsavar for SURF4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1059773 -- 133,361,989(-) ATCGA(C/G/T)CAATG utr-variant-3-prime
rs1179033 -- 133,367,248(+) CCGCA(A/G)AGCCA intron-variant
rs1179034 -- 133,368,597(+) AGCAA(C/T)GAAAC intron-variant
rs1179035 -- 133,368,917(+) GAGGC(A/G)AGCGA intron-variant
rs1179036 -- 133,370,663(+) ACAGG(C/G)AGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SURF4 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
dgv8325n71 CNV Loss 21882294
nsv894076 CNV Loss 21882294
nsv894080 CNV Loss 21882294
nsv894081 CNV Loss 21882294

Variation tolerance for SURF4 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SURF4 Gene

Disorders for SURF4 Gene

Relevant External Links for SURF4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SURF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SURF4 Gene

Publications for SURF4 Gene

  1. The surf-4 gene encodes a novel 30 kDa integral membrane protein. (PMID: 7540914) Reeves J.E. … Fried M. (Mol. Membr. Biol. 1995) 2 3 4 67
  2. The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1. (PMID: 8499913) Yon J. … Fried M. (Hum. Mol. Genet. 1993) 2 3
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SURF4 Gene

Sources for SURF4 Gene