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Aliases for SURF4 Gene

Aliases for SURF4 Gene

  • Surfeit 4 2 3
  • Surface 4 Integral Membrane Protein 2 3
  • Surfeit Locus Protein 4 2
  • SURF-4 4
  • ERV29 3

External Ids for SURF4 Gene

Previous GeneCards Identifiers for SURF4 Gene

  • GC09M127318
  • GC09M127785
  • GC09M129582
  • GC09M131504
  • GC09M133257
  • GC09M135206
  • GC09M135218
  • GC09M136228
  • GC09M105728

Summaries for SURF4 Gene

Entrez Gene Summary for SURF4 Gene

  • This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for SURF4 Gene

SURF4 (Surfeit 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SURF4 Gene

  • May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.

Gene Wiki entry for SURF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SURF4 Gene

Genomics for SURF4 Gene

Regulatory Elements for SURF4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SURF4 Gene

Chromosome:
9
Start:
133,361,449 bp from pter
End:
133,377,949 bp from pter
Size:
16,501 bases
Orientation:
Minus strand

Genomic View for SURF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SURF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SURF4 Gene

Proteins for SURF4 Gene

  • Protein details for SURF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15260-SURF4_HUMAN
    Recommended name:
    Surfeit locus protein 4
    Protein Accession:
    O15260
    Secondary Accessions:
    • B7Z6A4
    • O60923
    • Q5T8U6
    • Q9UNZ0
    • Q9UNZ1

    Protein attributes for SURF4 Gene

    Size:
    269 amino acids
    Molecular mass:
    30394 Da
    Quaternary structure:
    • Found in a complex composed at least of SURF4, TMED2 and TMED10. May interact with LMAN1.

    Alternative splice isoforms for SURF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SURF4 Gene

Proteomics data for SURF4 Gene at MOPED

Post-translational modifications for SURF4 Gene

  • Ubiquitination at Lys 139
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SURF4 Gene

Domains & Families for SURF4 Gene

Protein Domains for SURF4 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15260

UniProtKB/Swiss-Prot:

SURF4_HUMAN :
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins
  • Belongs to the SURF4 family.
Domain:
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins
Family:
  • Belongs to the SURF4 family.
genes like me logo Genes that share domains with SURF4: view

No data available for Gene Families for SURF4 Gene

Function for SURF4 Gene

Molecular function for SURF4 Gene

GENATLAS Biochemistry:
surfeit 4 (see SURF@),putative integral membrane protein of the endoplasmic reticulum,30kDa
UniProtKB/Swiss-Prot Function:
May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.

Gene Ontology (GO) - Molecular Function for SURF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18287528
genes like me logo Genes that share ontologies with SURF4: view
genes like me logo Genes that share phenotypes with SURF4: view

Animal Model Products

miRNA for SURF4 Gene

miRTarBase miRNAs that target SURF4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SURF4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SURF4 Gene

Localization for SURF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SURF4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SURF4 Gene COMPARTMENTS Subcellular localization image for SURF4 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for SURF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0016021 integral component of membrane IEA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
genes like me logo Genes that share ontologies with SURF4: view

Pathways & Interactions for SURF4 Gene

SuperPathways for SURF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SURF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 18287528
GO:0010638 positive regulation of organelle organization IMP 18287528
GO:0032527 NOT protein exit from endoplasmic reticulum IMP 18287528
GO:0034498 NOT early endosome to Golgi transport IMP 18287528
genes like me logo Genes that share ontologies with SURF4: view

No data available for Pathways by source and SIGNOR curated interactions for SURF4 Gene

Drugs & Compounds for SURF4 Gene

No Compound Related Data Available

Transcripts for SURF4 Gene

Unigene Clusters for SURF4 Gene

Surfeit 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SURF4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SURF4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - -
SP7: -
SP8: - - - - - -
SP9:
SP10: - - - - - -

Relevant External Links for SURF4 Gene

GeneLoc Exon Structure for
SURF4
ECgene alternative splicing isoforms for
SURF4

Expression for SURF4 Gene

mRNA expression in normal human tissues for SURF4 Gene

Protein differential expression in normal tissues from HIPED for SURF4 Gene

This gene is overexpressed in Nasal epithelium (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SURF4 Gene



SOURCE GeneReport for Unigene cluster for SURF4 Gene Hs.512465

genes like me logo Genes that share expression patterns with SURF4: view

Protein tissue co-expression partners for SURF4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SURF4 Gene

Orthologs for SURF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SURF4 Gene

Organism Taxonomy Gene Similarity Type Details
rat
(Rattus norvegicus)
Mammalia Surf4 35
  • 89.71 (n)
  • 99.26 (a)
chimpanzee
(Pan troglodytes)
Mammalia SURF4 35
  • 99.88 (n)
  • 100 (a)
SURF4 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Surf4 35
  • 90.21 (n)
  • 99.26 (a)
Surf4 36
  • 99 (a)
OneToOne
Surf4 16
dog
(Canis familiaris)
Mammalia SURF4 35
  • 90.41 (n)
  • 96.9 (a)
SURF4 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SURF4 35
  • 91.33 (n)
  • 99.26 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SURF4 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
chicken
(Gallus gallus)
Aves SURF4 35
  • 81.04 (n)
  • 93.31 (a)
SURF4 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SURF4 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33420 35
tropical clawed frog
(Silurana tropicalis)
Amphibia surf4.2 35
  • 80.42 (n)
  • 91.45 (a)
MGC76061 35
zebrafish
(Danio rerio)
Actinopterygii zgc65806 35
surf4 35
  • 79.68 (n)
  • 88.1 (a)
surf4l 36
  • 87 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Surf4 35
  • 64.41 (n)
  • 59.77 (a)
Surf4 37
  • 59 (a)
Surf4 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001069 35
  • 58.52 (n)
  • 63.16 (a)
worm
(Caenorhabditis elegans)
Secernentea sft-4 35
  • 60.07 (n)
  • 58.96 (a)
T02E1.7 37
  • 33 (a)
sft-4 37
  • 58 (a)
sft-4 36
  • 57 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV29 35
  • 45.56 (n)
  • 37.08 (a)
ERV29 38
ERV29 36
  • 29 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03102g 35
  • 46.48 (n)
  • 35.86 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL340C 35
  • 48.54 (n)
  • 35.36 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03319 35
  • 50.97 (n)
  • 38.61 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3084 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5467 36
  • 58 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC970.06 35
  • 45.8 (n)
  • 37.01 (a)
Species with no ortholog for SURF4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SURF4 Gene

ENSEMBL:
Gene Tree for SURF4 (if available)
TreeFam:
Gene Tree for SURF4 (if available)

Paralogs for SURF4 Gene

No data available for Paralogs for SURF4 Gene

Variants for SURF4 Gene

Sequence variations from dbSNP and Humsavar for SURF4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3124754 -- 133,373,718(-) ctggt(C/T)tcgaa intron-variant, upstream-variant-2KB
rs7028346 -- 133,365,348(+) TCTGT(C/T)CTCCA intron-variant
rs7049020 -- 133,368,925(+) CGAAC(A/G)TCAGC intron-variant
rs35179017 -- 133,365,813(+) ATTGG(C/G)TGAGC intron-variant
rs35337827 -- 133,362,254(+) GACTA(-/C)CCCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SURF4 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
dgv8325n71 CNV Loss 21882294
nsv894076 CNV Loss 21882294
nsv894080 CNV Loss 21882294
nsv894081 CNV Loss 21882294

Variation tolerance for SURF4 Gene

Residual Variation Intolerance Score: 31.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SURF4 Gene

HapMap Linkage Disequilibrium report
SURF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SURF4 Gene

Disorders for SURF4 Gene

Relevant External Links for SURF4

Genetic Association Database (GAD)
SURF4
Human Genome Epidemiology (HuGE) Navigator
SURF4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SURF4
genes like me logo Genes that share disorders with SURF4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SURF4 Gene

Publications for SURF4 Gene

  1. The surf-4 gene encodes a novel 30 kDa integral membrane protein. (PMID: 7540914) Reeves J.E. … Fried M. (Mol. Membr. Biol. 1995) 2 67
  2. The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1. (PMID: 8499913) Yon J. … Fried M. (Hum. Mol. Genet. 1993) 2 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  5. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 67

Products for SURF4 Gene

Sources for SURF4 Gene

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