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Aliases for SURF4 Gene

Aliases for SURF4 Gene

  • Surfeit 4 2 3
  • Surface 4 Integral Membrane Protein 2 3
  • Surfeit Locus Protein 4 2 3
  • SURF-4 4
  • ERV29 3

External Ids for SURF4 Gene

Previous GeneCards Identifiers for SURF4 Gene

  • GC09M127318
  • GC09M127785
  • GC09M129582
  • GC09M131504
  • GC09M133257
  • GC09M135206
  • GC09M135218
  • GC09M136228
  • GC09M105728

Summaries for SURF4 Gene

Entrez Gene Summary for SURF4 Gene

  • This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for SURF4 Gene

SURF4 (Surfeit 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SURF4 Gene

  • May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.

Gene Wiki entry for SURF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SURF4 Gene

Genomics for SURF4 Gene

Regulatory Elements for SURF4 Gene

Genomic Location for SURF4 Gene

Start:
133,361,449 bp from pter
End:
133,377,949 bp from pter
Size:
16,501 bases
Orientation:
Minus strand

Genomic View for SURF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SURF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SURF4 Gene

Proteins for SURF4 Gene

  • Protein details for SURF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15260-SURF4_HUMAN
    Recommended name:
    Surfeit locus protein 4
    Protein Accession:
    O15260
    Secondary Accessions:
    • B7Z6A4
    • O60923
    • Q5T8U6
    • Q9UNZ0
    • Q9UNZ1

    Protein attributes for SURF4 Gene

    Size:
    269 amino acids
    Molecular mass:
    30394 Da
    Quaternary structure:
    • Found in a complex composed at least of SURF4, TMED2 and TMED10. May interact with LMAN1.

    Alternative splice isoforms for SURF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SURF4 Gene

Proteomics data for SURF4 Gene at MOPED

Post-translational modifications for SURF4 Gene

  • Ubiquitination at Lys139
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SURF4 Gene

Domains for SURF4 Gene

Protein Domains for SURF4 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15260

UniProtKB/Swiss-Prot:

SURF4_HUMAN :
  • O15260
Domain:
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins
Family:
  • Belongs to the SURF4 family.
genes like me logo Genes that share domains with SURF4: view

No data available for Gene Families for SURF4 Gene

Function for SURF4 Gene

Molecular function for SURF4 Gene

GENATLAS Biochemistry: surfeit 4 (see SURF@),putative integral membrane protein of the endoplasmic reticulum,30kDa
UniProtKB/Swiss-Prot Function: May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.

Gene Ontology (GO) - Molecular Function for SURF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18287528
genes like me logo Genes that share ontologies with SURF4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SURF4 Gene

Localization for SURF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SURF4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SURF4 Gene COMPARTMENTS Subcellular localization image for SURF4 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SURF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005794 Golgi apparatus --
genes like me logo Genes that share ontologies with SURF4: view

Pathways for SURF4 Gene

SuperPathways for SURF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SURF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 18287528
GO:0010638 positive regulation of organelle organization IMP 18287528
GO:0032527 NOT protein exit from endoplasmic reticulum IMP 18287528
GO:0034498 NOT early endosome to Golgi transport IMP 18287528
genes like me logo Genes that share ontologies with SURF4: view

No data available for Pathways by source for SURF4 Gene

Transcripts for SURF4 Gene

Unigene Clusters for SURF4 Gene

Surfeit 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SURF4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - -
SP7: -
SP8: - - - - - -
SP9:
SP10: - - - - - -

Relevant External Links for SURF4 Gene

GeneLoc Exon Structure for
SURF4
ECgene alternative splicing isoforms for
SURF4

Expression for SURF4 Gene

mRNA expression in normal human tissues for SURF4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SURF4 Gene

SOURCE GeneReport for Unigene cluster for SURF4 Gene Hs.512465

genes like me logo Genes that share expressions with SURF4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SURF4 Gene

Orthologs for SURF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SURF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SURF4 35
  • 99.88 (n)
  • 100 (a)
SURF4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SURF4 35
  • 91.33 (n)
  • 99.26 (a)
dog
(Canis familiaris)
Mammalia SURF4 35
  • 90.41 (n)
  • 96.9 (a)
SURF4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Surf4 35
  • 90.21 (n)
  • 99.26 (a)
Surf4 16
Surf4 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SURF4 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Surf4 35
  • 89.71 (n)
  • 99.26 (a)
chicken
(Gallus gallus)
Aves SURF4 35
  • 81.04 (n)
  • 93.31 (a)
SURF4 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SURF4 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33420 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76061 35
surf4.2 35
  • 80.42 (n)
  • 91.45 (a)
zebrafish
(Danio rerio)
Actinopterygii surf4 35
  • 79.68 (n)
  • 88.1 (a)
surf4l 36
  • 87 (a)
OneToOne
zgc65806 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001069 35
  • 58.52 (n)
  • 63.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta Surf4 35
  • 64.41 (n)
  • 59.77 (a)
Surf4 36
  • 59 (a)
OneToOne
Surf4 37
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea sft-4 35
  • 60.07 (n)
  • 58.96 (a)
sft-4 36
  • 57 (a)
OneToOne
T02E1.7 37
  • 33 (a)
sft-4 37
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL340C 35
  • 48.54 (n)
  • 35.36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV29 35
  • 45.56 (n)
  • 37.08 (a)
ERV29 36
  • 29 (a)
OneToOne
ERV29 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03102g 35
  • 46.48 (n)
  • 35.86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03319 35
  • 50.97 (n)
  • 38.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC970.06 35
  • 45.8 (n)
  • 37.01 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3084 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5467 36
  • 58 (a)
OneToOne
Species with no ortholog for SURF4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SURF4 Gene

ENSEMBL:
Gene Tree for SURF4 (if available)
TreeFam:
Gene Tree for SURF4 (if available)

Paralogs for SURF4 Gene

No data available for Paralogs for SURF4 Gene

Variants for SURF4 Gene

Sequence variations from dbSNP and Humsavar for SURF4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2494 -- 133,362,957(-) GAATA(C/G)TGAAA utr-variant-3-prime
rs11101 -- 133,361,856(+) TCATA(C/T)GGCAC utr-variant-3-prime
rs1059773 -- 133,361,989(-) ATCGA(C/G/T)CAATG utr-variant-3-prime
rs1179033 -- 133,367,248(+) CCGCA(A/G)AGCCA intron-variant
rs1179034 -- 133,368,597(+) AGCAA(C/T)GAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SURF4 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
dgv8325n71 CNV Loss 21882294
nsv894076 CNV Loss 21882294
nsv894080 CNV Loss 21882294
nsv894081 CNV Loss 21882294

Relevant External Links for SURF4 Gene

HapMap Linkage Disequilibrium report
SURF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SURF4 Gene

Disorders for SURF4 Gene

Relevant External Links for SURF4

Genetic Association Database (GAD)
SURF4
Human Genome Epidemiology (HuGE) Navigator
SURF4
genes like me logo Genes that share disorders with SURF4: view

No data available for UniProtKB/Swiss-Prot for SURF4 Gene

Publications for SURF4 Gene

  1. The surf-4 gene encodes a novel 30 kDa integral membrane protein. (PMID: 7540914) Reeves J.E. … Fried M. (Mol. Membr. Biol. 1995) 2 3 4
  2. The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1. (PMID: 8499913) Yon J. … Fried M. (Hum. Mol. Genet. 1993) 2 3
  3. The human Surfeit locus. (PMID: 9740673) Duhig T. … Fried M. (Genomics 1998) 3 4
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  5. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. (PMID: 15308636) Breuza L. … Hauri H.-P. (J. Biol. Chem. 2004) 3 4

Products for SURF4 Gene

Sources for SURF4 Gene

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