SURF2 Gene
protein-coding GIFtS: 47
GCID: GC09P136223
|
|
surfeit 2
| |
Aliases
for SURF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Surfeit 21 2 | | SURF-22 | | Surfeit Locus Protein 22 | | Surf-23 |
Export aliases for SURF2 gene to outside databasesPrevious GC identifers: GC09P127313 GC09P127780 GC09P129577 GC09P131499 GC09P133252 GC09P135213 GC09P105723 |
Summaries
for SURF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SURF2:
This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequencesimilarity. The gene shares a bidirectional promoter with SURF1, which is located on the opposite strand. The functionof the encoded protein from this housekeeping gene has not yet been determined. (provided by RefSeq, Jul 2008)
|
Genomic Views
for SURF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_035014.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SURF2 gene promoter:
ER-alpha HTF Pax-2 Pax-2a FOXL1 PPAR-gamma1 Pax-2b HOXA5 Sox9
Other transcription factors
Search SABiosciences Chromatin IP Primers for SURF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SURF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.2 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q33-q34SURF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P136223: view genomic region
(about GC identifiers)
Start:
|
136,223,421 bp from pter |
End:
|
136,228,045 bp from pter |
Size:
|
4,625 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr9+,PATCHES 136,226,873-136,231,492 |
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Proteins
for SURF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SURF2_HUMAN, Q15527 (See
protein sequence)Recommended Name: Surfeit locus protein 2 Size: 256 amino acids; 29648 Da
Secondary accessions: Q6IBP9 Q96CD1Explore the universe of human proteins at neXtProt for SURF2: NX_Q15527
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15527
SURF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_059973.3
ENSEMBL proteins: ENSP00000361032
Human Recombinant Protein Products for SURF2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
SURF2 for ontologies About GeneDecksing
SURF2 Antibody Products:
Assay Products for SURF2: |
Protein
Domains /
Families
for SURF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SURF2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q15527ProtoNet protein and cluster: Q15527 1 Blocks protein family: IPB008833 Surfeit locus 2
UniProtKB/Swiss-Prot: SURF2_HUMAN, Q15527Similarity: Belongs to the SURF2 family |
Function
for SURF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
Genatlas biochemistry entry for SURF2:surfeit 2 (see SURF@)
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
SURF2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SURF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SURF2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SURF2 (NM_017503) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SURF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SURF2 |
|
Pathways & Interactions
for SURF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SURF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/9 Interacting proteins for SURF2 (Q155272, 3 ENSP000003610324) via UniProtKB, MINT, STRING, and/or I2D (see all 9)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| B4GALT3 | O605122, 3, ENSP000003209654 | MINT-63176 I2D:
score=4 STRING: ENSP00000320965 | | RPL5 | P467772, 3, ENSP000003593454 | MINT-8272421 I2D:
score=2 STRING: ENSP00000359345 | | ZNF331 | Q9NQX62, 3, ENSP000002531444 | MINT-8272432 I2D:
score=2 STRING: ENSP00000253144 | | NPTN | Q9Y6392, 3, ENSP000002904014 | MINT-8272410 I2D:
score=2 STRING: ENSP00000290401 | | PLAUR | Q034052, 3, ENSP000003393284 | MINT-64051 I2D:
score=4 STRING: ENSP00000339328 |
About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
SURF2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SURF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SURF2
Search CenterWatch for drugs/clinical trials and news about SURF2
|
Transcripts
for SURF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SURF2 gene: NM_017503.3 Unigene Cluster for SURF2: Surfeit 2 Hs.159448 [show with all ESTs]Unigene Representative Sequence: BM9108123 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371964(uc004cdi.2) ENST00000495524 ENST00000486887
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SURF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SURF2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SURF2 (NM_017503) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SURF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SURF2 |
Additional cDNA sequence: BC014411.1 CR456753.1 Z35094.1 7 DOTS entries: DT.92423075 DT.111695 DT.95160197 DT.97807686 DT.102823899 DT.100024022 DT.100711209 24/3637 AceView cDNA sequences (see all 3637): BQ435036 BQ058012 BM903990 BM017098 BE796926 BQ940952 BQ944920 BE312283 BQ054806 BU629315 BQ072167 BQ649122 BI856078 BG393110 CA423090 AI272858 BM559030 F20644 BQ063046 BQ924639 BM045881 BE898457 BQ924979 BU629904
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SURF2 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | - | | - | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SURF2
|
Expression
for SURF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SURF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGTGAAAAA
About this image
See SURF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SURF2
SOURCE GeneReport for Unigene cluster: Hs.159448
SABiosciences Custom PCR Arrays for SURF2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SURF2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SURF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SURF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SURF2 |
Orthologs
for SURF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SURF2 gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for SURF2 (if available)
TreeFam Gene Tree for SURF2 (if available) |
Paralogs
for SURF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SURF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SURF2 (136223421 - 136228045 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SURF2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SURF2 |
|
Disorders
/ Diseases
for SURF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SURF2 for disorders About MalaCards
SURF2 for disorders About GeneDecksing
OMIM gene information: 185630
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: SURF2 (3 documents)
Export disorders for SURF2 gene to outside databases
|
Publications
for SURF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SURF2 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with SURF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The Surf-1 and Surf-2 genes and their essential bidirectional promoter elements are conserved between mouse and human. (PubMed id 7702754)1, 2 Lennard A.... Fried M. (1994)
- Genetic associations for activated partial thromboplas tin time and prothrombin time, their gene expression profiles, and risk of coron ary artery disease. (PubMed id 22703881)1 Tang W....Folsom A.R. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for SURF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SURF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SURF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SURF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SURF2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SURF2 gene:
Search GeneIP for patents involving SURF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SURF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SURF2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SURF2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SURF2 | | | OriGene Protein Over-expression Lysate for SURF2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SURF2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SURF2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SURF2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SURF2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SURF2 | | OriGene Custom Protein Services for SURF2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SURF2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SURF2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SURF2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SURF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SURF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SURF2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SURF2 |
| |  |  |  |  | | | | |
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 | | | SURF2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibodies for SURF2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SURF2 |
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