SURF1 Gene
protein-coding GIFtS: 56
GCID: GC09M136218
|
|
surfeit 1
| |
Aliases
for SURF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Surfeit 11 2 | | Surfeit Locus Protein 12 | | SURF-13 |
Export aliases for SURF1 gene to outside databasesPrevious GC identifers: GC09M127308 GC09M127775 GC09M129572 GC09M131494 GC09M133248 GC09M135208 GC09M105718 |
Summaries
for SURF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SURF1:
This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesisof the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeastprotein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightlylinked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on theopposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonlyassociated with systemic cytochrome c oxidase deficiency. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SURF1_HUMAN, Q15526Function: Probably involved in the biogenesis of the COX complex
Gene Wiki entry for SURF1
|
Genomic Views
for SURF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_035014.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SURF1 gene promoter:
HFH-3 ER-alpha HTF Lmo2 Nkx2-5 FOXL1 FOXI1 HOXA5 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SURF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SURF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.2 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q33-q34SURF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M136218: view genomic region
(about GC identifiers)
Start:
|
136,218,610 bp from pter |
End:
|
136,223,552 bp from pter |
Size:
|
4,943 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr9-,PATCHES 136,222,139-136,226,813 |
|
Proteins
for SURF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SURF1_HUMAN, Q15526 (See
protein sequence)Recommended Name: Surfeit locus protein 1 Size: 300 amino acids; 33331 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q5T8T3 Q5T8T4Alternative splicing: 2 isoforms: Q15526-1 Q15526-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SURF1: NX_Q15526
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15526
SURF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003163.1
ENSEMBL proteins: ENSP00000361042 ENSP00000397093
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SURF1 for ontologies About GeneDecksing
SURF1 Antibody Products:
Assay Products for SURF1: |
Protein
Domains /
Families
for SURF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SURF1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q15526ProtoNet protein and cluster: Q15526 1 Blocks protein family: IPB002994 Surf1 protein
UniProtKB/Swiss-Prot: SURF1_HUMAN, Q15526Similarity: Belongs to the SURF1 family |
Function
for SURF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SURF1_HUMAN, Q15526Function: Probably involved in the biogenesis of the COX complex Genatlas biochemistry entry for SURF1:surfeit 1 (see SURF@),homolog of SHY1,yeast mitochondrial protein,member of a cluster of housekeeping gene,putativelyinvolved in the assembly or maintenance of an active cytochrome oxidase complex,ubiquitously expressed,located intightly bound to the mitochondrial inner membrane
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SURF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SURF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SURF1 (NM_003172) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SURF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SURF1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004129 | cytochrome-c oxidase activity |
IEA | -- |
SURF1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for SURF1: Surf1tm2Zev Surf1tm2.1Zev Surf1tm1Zev
9 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Surf1):
SURF1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SURF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Type II diabetes mellitus | |
2  BioSystems Pathways for SURF1
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SURF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/21 Interacting proteins for SURF1 (Q155263 ENSP000003610424) via UniProtKB, MINT, STRING, and/or I2D (see all 21)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
SURF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SURF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SURF1 for compounds About GeneDecksing
 Browse Tocris compounds for SURF1
4 Novoseek chemical compound relationships for SURF1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lactate |
22 |
3 |
20436434 (1), 19780766 (1) |
| pyruvate |
16.7 |
1 |
11279059 (1) |
| bicarbonate |
2.46 |
1 |
11804207 (1) |
| oxygen |
0 |
2 |
15269007 (2) |
Search CenterWatch for drugs/clinical trials and news about SURF1
|
Transcripts
for SURF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SURF1 gene: NM_003172.2 Unigene Cluster for SURF1: Surfeit 1 Hs.512464 [show with all ESTs]Unigene Representative Sequence: BM9230554 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371974(uc004cdh.1) ENST00000495952 ENST00000437995 ENST00000463965
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SURF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SURF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SURF1 (NM_003172) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SURF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SURF1 |
Additional cDNA sequence: AK291122.1 BC028314.1 BC071658.1 Z35093.1 9 DOTS entries: DT.97815595 DT.415300 DT.415301 DT.91752981 DT.102823899 DT.100773920 DT.100702133 DT.121151751 DT.100023995 24/1147 AceView cDNA sequences (see all 1147): BM784110 AA777354 BF514617 BM993930 BE855585 BF445633 BM755901 BU902343 CR602588 BM548801 CA437981 BM742778 BQ876428 BE145526 CR613298 CK431188 AA933680 AL138333 CR604442 BM563209 BM745977 BM756508 BU624851 CF128306
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SURF1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SURF1
|
Expression
for SURF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SURF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTACTGGT
About this image
See SURF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SURF1
SOURCE GeneReport for Unigene cluster: Hs.512464
SABiosciences Custom PCR Arrays for SURF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SURF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SURF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SURF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SURF1 |
Orthologs
for SURF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SURF1 gene from 8/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Surf11 , 5 |
surfeit gene 11, 5 |
79.69(n)1
79.8(a)1 |
|
2 (19.10 cM)5
209301 NM_013677.21 NP_038705.21
269133835 |
chicken
(Gallus gallus) |
Aves |
SURF11 |
surfeit 1 |
69.93(n)
69.8(a) |
|
417157 NM_001012653.2 NP_001012671.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.237332 |
Xenopus laevis transcribed sequence with weak similarity more |
73.44(n) |
|
AW640345.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.145682 |
Transcribed sequence with moderate similarity to protein more |
75.07(n) |
|
BM571196.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Surf11 , 3 |
cytochrome biogenesis heme transporter3
Surfeit 11 |
46(a)3
53.36(n)1
47.67(a)1 |
|
65D53
444981 NM_080019.31 NP_524758.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
sft-11 , 3 |
Protein SFT-11 |
45(a)3
50.22(n)1
46.29(a)1 |
|
III(3158521-3163467)3
1754151 NM_065256.21 NP_497657.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SURF11 |
Surfeit locus 1 cytochrome c oxidase biogenesis protein |
46.81(n)
35.74(a) |
|
821310 NM_112672.2 NP_566592.1 |
rice
(Oryza sativa) |
Liliopsida |
Os03g02007001 |
hypothetical protein |
45.61(n)
33.46(a) |
|
4331968 NM_001055826.1 NP_001049291.1 |
ENSEMBL Gene Tree for SURF1 (if available)
TreeFam Gene Tree for SURF1 (if available) |
Paralogs
for SURF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SURF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SURF1 (136218610 - 136223552 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SURF1: --
Human Gene Mutation Database (HGMD): SURF1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SURF1 |
|
Disorders
/ Diseases
for SURF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SURF1 for disorders About GeneDecksing
OMIM gene information: 185620
OMIM disorders: 256000
UniProtKB/Swiss-Prot: SURF1_HUMAN, Q15526
Defects in SURF1 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disordercharacterized by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associatedwith systemic cytochrome c oxidase (COX) deficiency
17  diseases for SURF1: About MalaCardsleigh syndrome, due to cox deficiency leigh-like syndrome mitochondrial encephalomyopathy lactic acidosis
cardioencephalomyopathy encephalomyopathy esophageal squamous cell carcinoma squamous cell carcinoma
leukodystrophy peripheral neuropathy neurodegenerative disease hypertrichosis
leigh disease neuropathy crohn's disease esophagitis
carcinoma
2 diseases from the University of Copenhagen DISEASES database for SURF1:Leigh disease Hypertrichosis 8 Novoseek disease relationships for SURF1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leigh syndrome |
98 |
83 |
11509016 (3), 11955926 (3), 11279059 (3), 16120373 (3) (see all 57) |
| cytochrome c oxidase deficiency |
97.5 |
30 |
11955926 (3), 11279059 (3), 12026244 (2), 16225813 (2) (see all 22) |
| mitochondrial diseases |
79 |
1 |
9837813 (1) |
| leukodystrophy |
68 |
6 |
11409433 (3), 11044474 (1), 19805825 (1) |
| neurodegenerative diseases |
50.1 |
3 |
9843204 (1), 10556303 (1), 19780766 (1) |
| acidosis lactic |
47.3 |
1 |
11409433 (1) |
| encephalopathy |
46 |
3 |
11579424 (1), 15214016 (1), 10805329 (1) |
| neurological disorders |
11.5 |
2 |
11782424 (1), 15269007 (1) |
Genatlas disease: SURF1 subacute necrotizing encephalopathy Leigh syndrome characterized by lactate acidosis,bilaterally symmetrical necroticlesions in the brainstem,basal ganglia,thalamus and spinal cord,occuring predominantly in infants and associated witha systemic deficit in cytochrome c oxidase
Genetic Association Database (GAD): SURF1
Human Genome Epidemiology (HuGE) Navigator: SURF1 (7 documents)
Export disorders for SURF1 gene to outside databases
|
Publications
for SURF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SURF1 gene, integrated from 9 sources (see all 114):
(articles sorted by number of sources associating them with SURF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in the SURF1 gene associated with Leigh syndrome and cytochrome C oxidase deficiency. (PubMed id 11317352)1, 2, 4, 9 Pequignot M.O.... Marsac C. (2001)
- Missense mutations in SURF1 associated with deficient cytochrome c oxidase assembly in Leigh syndrome patients. (PubMed id 10746561)1, 2, 4, 9 Poyau A.... Godinot C. (2000)
- SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome. (PubMed id 9843204)1, 2, 3, 9 Zhu Z.... Shoubridge E.A. (1998)
- The Surf-1 and Surf-2 genes and their essential bidirectional promoter elements are conserved between mouse and human. (PubMed id 7702754)1, 2, 9 Lennard A.... Fried M. (1994)
- Two novel mutations of SURF1 in Leigh syndrome with cytochrome c oxidase deficiency. (PubMed id 10647889)1, 2, 9 Teraoka M....Seino Y. (1999)
- The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1. (PubMed id 8499913)1, 3, 9 Yon J....Fried M. (1993)
- SURF1-associated leigh syndrome: A case series and novel mutations. (PubMed id 22488715)1, 2 Lee I.C....Wong L.J. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- [A new missense mutation of 574C>T in the SURF1 gene--biochemical and molecular genetic study in seven children with Leigh syndrome] (PubMed id 12515039)1, 9 Capkova M....Zeman J. (2002)
- SURF1 missense mutations promote a mild Leigh phenoty pe. (PubMed id 19780766)1, 9 Piekutowska-Abramczuk D....Pronicka E. (2009)
|
External Searches for SURF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SURF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SURF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SURF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SURF1 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SURF1 |
|
| | |
About This Section
| Patent Information for SURF1 gene:
Search GeneIP for patents involving SURF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SURF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SURF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SURF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SURF1 | | | OriGene Protein Over-expression Lysate for SURF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SURF1 | | OriGene 3'-UTR Clone for SURF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SURF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SURF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SURF1 | | OriGene Custom Protein Services for SURF1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SURF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SURF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SURF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SURF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SURF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SURF1 |
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| | | | Search Tocris compounds for SURF1 |
| |  |  |  |  | | | | | | Recombinant Protein for SURF1 |
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 | | | SURF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SURF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SURF1 |
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