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Aliases for SUPV3L1 Gene

Aliases for SUPV3L1 Gene

  • Suppressor Of Var1, 3-Like 1 (S. Cerevisiae) 2 3
  • SUV3-Like Protein 1 3 4
  • SUV3 3 4
  • ATP-Dependent RNA Helicase SUPV3L1, Mitochondrial 3
  • Suppressor Of Var1 (S.Cerevisiae) 3-Like 1 2
  • Suppressor Of Var1 3-Like Protein 1 4
  • Suppressor Of Var1, 3-Like 1(SUV3) 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63

External Ids for SUPV3L1 Gene

Previous GeneCards Identifiers for SUPV3L1 Gene

  • GC10P069751
  • GC10P070026
  • GC10P070832
  • GC10P070284
  • GC10P070609
  • GC10P070939
  • GC10P064939

Summaries for SUPV3L1 Gene

GeneCards Summary for SUPV3L1 Gene

SUPV3L1 (Suppressor Of Var1, 3-Like 1 (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include RNA binding and helicase activity.

UniProtKB/Swiss-Prot for SUPV3L1 Gene

  • Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3 overhang double-stranded RNA with a 3-to-5 directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5-to-3 direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.

Gene Wiki entry for SUPV3L1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPV3L1 Gene

Genomics for SUPV3L1 Gene

Regulatory Elements for SUPV3L1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUPV3L1 Gene

Start:
69,180,232 bp from pter
End:
69,209,099 bp from pter
Size:
28,868 bases
Orientation:
Plus strand

Genomic View for SUPV3L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUPV3L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPV3L1 Gene

Proteins for SUPV3L1 Gene

  • Protein details for SUPV3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYB8-SUV3_HUMAN
    Recommended name:
    ATP-dependent RNA helicase SUPV3L1, mitochondrial
    Protein Accession:
    Q8IYB8
    Secondary Accessions:
    • A8K301
    • O43630

    Protein attributes for SUPV3L1 Gene

    Size:
    786 amino acids
    Molecular mass:
    87991 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homodimer; in free form. Component of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer containing 2 copies of SUPV3L1 and 3 copies of PNPT1. Interacts with LAMTOR5/HBXIP, WRN and BLM.

    Three dimensional structures from OCA and Proteopedia for SUPV3L1 Gene

neXtProt entry for SUPV3L1 Gene

Proteomics data for SUPV3L1 Gene at MOPED

Post-translational modifications for SUPV3L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SUPV3L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for SUPV3L1 Gene

Protein Domains for SUPV3L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SUPV3L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYB8

UniProtKB/Swiss-Prot:

SUV3_HUMAN :
  • Q8IYB8
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the helicase family.
genes like me logo Genes that share domains with SUPV3L1: view

No data available for Gene Families for SUPV3L1 Gene

Function for SUPV3L1 Gene

Molecular function for SUPV3L1 Gene

GENATLAS Biochemistry: yeast mitochondrial protein homolog,putative ATP-dependent RNA helicase
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=41.9 uM for ATP {ECO:0000269 PubMed:12466530, ECO:0000269 PubMed:15096047}; pH dependence: Optimum pH is 5.0. {ECO:0000269 PubMed:12466530, ECO:0000269 PubMed:15096047}; Temperature dependence: Optimum temperature is 30 degrees Celsius. {ECO:0000269 PubMed:12466530, ECO:0000269 PubMed:15096047};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Helicase activity toward DNA substrate is inhibited by micromolar concentrations of 5,6-dichloro-1-(beta-D-ribofuranosyl)benzotriazole (DRBT) and 4,5,6,7-tetrabromobenzotriazole (TBBT). Helicase activity toward RNA substrate is inhibited by elevated concentrations of TBBT. Inhibited by some ring-expanded nucleoside analogs.
UniProtKB/Swiss-Prot Function: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3 overhang double-stranded RNA with a 3-to-5 directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5-to-3 direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.

Enzyme Numbers (IUBMB) for SUPV3L1 Gene

Gene Ontology (GO) - Molecular Function for SUPV3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IMP 12466530
GO:0003678 DNA helicase activity IMP 12466530
GO:0003723 RNA binding TAS 9925937
GO:0003725 double-stranded RNA binding IDA 19509288
GO:0004004 ATP-dependent RNA helicase activity IDA 19509288
genes like me logo Genes that share ontologies with SUPV3L1: view
genes like me logo Genes that share phenotypes with SUPV3L1: view

Animal Models for SUPV3L1 Gene

MGI Knock Outs for SUPV3L1:

Animal Model Products

CRISPR Products

miRNA for SUPV3L1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUPV3L1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for SUPV3L1 Gene

Localization for SUPV3L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUPV3L1 Gene

Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUPV3L1 Gene COMPARTMENTS Subcellular localization image for SUPV3L1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SUPV3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17352692
GO:0005739 mitochondrion IDA 17352692
GO:0005759 mitochondrial matrix IDA 12466530
GO:0042645 mitochondrial nucleoid IDA 18063578
GO:0045025 mitochondrial degradosome IDA 19509288
genes like me logo Genes that share ontologies with SUPV3L1: view

Pathways for SUPV3L1 Gene

SuperPathways for SUPV3L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUPV3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000958 mitochondrial mRNA catabolic process IMP 19864255
GO:0000962 positive regulation of mitochondrial RNA catabolic process IMP 19864255
GO:0000965 mitochondrial RNA 3-end processing IMP 19864255
GO:0006200 obsolete ATP catabolic process --
GO:0006310 DNA recombination IMP 17961633
genes like me logo Genes that share ontologies with SUPV3L1: view

No data available for Pathways by source for SUPV3L1 Gene

Compounds for SUPV3L1 Gene

(2) HMDB Compounds for SUPV3L1 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
genes like me logo Genes that share compounds with SUPV3L1: view

Transcripts for SUPV3L1 Gene

Unigene Clusters for SUPV3L1 Gene

Suppressor of var1, 3-like 1 (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUPV3L1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUPV3L1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2: -
SP3: -
SP4:
SP5: - - - - - - - - -

Relevant External Links for SUPV3L1 Gene

GeneLoc Exon Structure for
SUPV3L1
ECgene alternative splicing isoforms for
SUPV3L1

Expression for SUPV3L1 Gene

mRNA expression in normal human tissues for SUPV3L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUPV3L1 Gene

SOURCE GeneReport for Unigene cluster for SUPV3L1 Gene Hs.106469

mRNA Expression by UniProt/SwissProt for SUPV3L1 Gene

Q8IYB8-SUV3_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expressions with SUPV3L1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SUPV3L1 Gene

Orthologs for SUPV3L1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUPV3L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUPV3L1 35
  • 99.79 (n)
  • 99.75 (a)
SUPV3L1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUPV3L1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUPV3L1 35
  • 90.33 (n)
  • 90.71 (a)
SUPV3L1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Supv3l1 35
  • 84.53 (n)
  • 87.92 (a)
Supv3l1 16
Supv3l1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUPV3L1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUPV3L1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Supv3l1 35
  • 84.65 (n)
  • 88.39 (a)
chicken
(Gallus gallus)
Aves SUPV3L1 35
  • 70.77 (n)
  • 73.03 (a)
SUPV3L1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUPV3L1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10077 35
supv3l1 35
  • 70.54 (n)
  • 74.13 (a)
zebrafish
(Danio rerio)
Actinopterygii supv3l1 35
  • 68.79 (n)
  • 73.19 (a)
supv3l1 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003508 35
  • 56.78 (n)
  • 61.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9791 35
  • 57.25 (n)
  • 61.45 (a)
CG9791 36
  • 56 (a)
OneToOne
CG9791 37
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea C08F8.2 36
  • 45 (a)
OneToOne
CELE_C08F8.2 35
  • 53.61 (n)
  • 49.69 (a)
C08F8.2 37
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUV3 36
  • 28 (a)
OneToOne
SUV3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G39840 35
  • 52.39 (n)
  • 48.1 (a)
rice
(Oryza sativa)
Liliopsida Os04g0459800 35
  • 51.25 (n)
  • 48.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for SUPV3L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUPV3L1 Gene

ENSEMBL:
Gene Tree for SUPV3L1 (if available)
TreeFam:
Gene Tree for SUPV3L1 (if available)

Paralogs for SUPV3L1 Gene

No data available for Paralogs for SUPV3L1 Gene

Variants for SUPV3L1 Gene

Sequence variations from dbSNP and Humsavar for SUPV3L1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs868782 -- 69,195,804(-) AACTG(C/T)GCCAT intron-variant
rs868783 -- 69,195,520(-) ATAAA(C/T)TGTAG intron-variant
rs906217 -- 69,194,905(+) CTGCA(C/T)TTAAC intron-variant
rs906218 -- 69,201,157(+) CTTCT(C/T)AGCAG intron-variant
rs954026 -- 69,186,094(+) AGGTA(C/T)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUPV3L1 Gene

Variant ID Type Subtype PubMed ID
nsv895694 CNV Gain 21882294
nsv508589 CNV Loss 20534489

Relevant External Links for SUPV3L1 Gene

HapMap Linkage Disequilibrium report
SUPV3L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUPV3L1 Gene

Disorders for SUPV3L1 Gene

Relevant External Links for SUPV3L1

Genetic Association Database (GAD)
SUPV3L1
Human Genome Epidemiology (HuGE) Navigator
SUPV3L1
genes like me logo Genes that share disorders with SUPV3L1: view

No data available for UniProtKB/Swiss-Prot for SUPV3L1 Gene

Publications for SUPV3L1 Gene

  1. Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP. (PMID: 16176273) Minczuk M. … Stepien P.P. (FEBS J. 2005) 2 3 4 23
  2. Down-regulation of human RNA/DNA helicase SUV3 induces apoptosis by a caspase- and AIF-dependent pathway. (PMID: 17352692) Szczesny R.J. … Stepien P.P. (Biol. Cell 2007) 3 4 23
  3. Assignment1 of SUPV3L1 to human chromosome band 10q22.1 by in situ hybridization. (PMID: 9925937) Dmochowska A. … Bartnik E. (Cytogenet. Cell Genet. 1998) 2 3
  4. Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA. (PMID: 12466530) Minczuk M. … Borowski P. (Nucleic Acids Res. 2002) 3 4
  5. Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change. (PMID: 15096047) Shu Z. … Lee W.-H. (Biochemistry 2004) 3 4

Products for SUPV3L1 Gene

Sources for SUPV3L1 Gene

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