Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SUPV3L1 Gene

Aliases for SUPV3L1 Gene

  • Suv3 Like RNA Helicase 2 3 5
  • SUV3-Like Protein 1 3 4
  • SUV3 3 4
  • ATP-Dependent RNA Helicase SUPV3L1, Mitochondrial 3
  • Suppressor Of Var1, 3-Like 1 (S. Cerevisiae) 2
  • Suppressor Of Var1 (S.Cerevisiae) 3-Like 1 2
  • Suppressor Of Var1 3-Like Protein 1 4
  • Suppressor Of Var1, 3-Like 1(SUV3) 3
  • Suppressor Of Var1, 3-Like 1 3
  • SUV3-Like Helicase 3
  • EC 3.6.4.13 4
  • EC 3.6.1 61

External Ids for SUPV3L1 Gene

Previous GeneCards Identifiers for SUPV3L1 Gene

  • GC10P069751
  • GC10P070026
  • GC10P070832
  • GC10P070284
  • GC10P070609
  • GC10P070939
  • GC10P064939

Summaries for SUPV3L1 Gene

GeneCards Summary for SUPV3L1 Gene

SUPV3L1 (Suv3 Like RNA Helicase) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and RNA binding.

UniProtKB/Swiss-Prot for SUPV3L1 Gene

  • Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3 overhang double-stranded RNA with a 3-to-5 directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5-to-3 direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.

Gene Wiki entry for SUPV3L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPV3L1 Gene

Genomics for SUPV3L1 Gene

Regulatory Elements for SUPV3L1 Gene

Enhancers for SUPV3L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G069122 1.5 FANTOM5 ENCODE 22.7 -55.8 -55756 3.1 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 SUPV3L1 TET1 CCAR1 VPS26A LOC101928994 HKDC1 SRGN DDX21 GC10P069153 GC10P069154
GH10G069219 1.6 Ensembl ENCODE dbSUPER 17.9 +43.1 43067 7.5 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B DMAP1 ZNF2 ZNF766 FOS JUNB SUPV3L1 HKDC1 ENSG00000231748 HK1 LOC101928994
GH10G069059 2 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -118.7 -118728 3.7 PKNOX1 SIN3A ZNF766 FOS TBX21 ZNF592 KAT8 SMARCA4 NBN NR2C1 CCAR1 SRGN DDX50 SUPV3L1 KIF1BP TET1 VPS26A DDX21 GC10P069071 GC10P069047
GH10G069213 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.3 +35.9 35865 5.3 PKNOX1 FOXA2 ARNT ZNF766 FOS ZNF263 SP3 ZNF592 SMARCA4 NBN HKDC1 LOC102723350 ENSG00000231748 HK1 TYSND1 SUPV3L1 SRGN VPS26A DDX21
GH10G068526 1.2 ENCODE 12.1 -652.9 -652909 2.2 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 MEF2D DDX50 DNA2 CCAR1 SUPV3L1 SIRT1 TET1 MIR1254-1 DDX21 RPL12P8 SLC25A16
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SUPV3L1 on UCSC Golden Path with GeneCards custom track

Promoters for SUPV3L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029207 296 1801 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D

Genomic Location for SUPV3L1 Gene

Chromosome:
10
Start:
69,180,204 bp from pter
End:
69,209,099 bp from pter
Size:
28,896 bases
Orientation:
Plus strand

Genomic View for SUPV3L1 Gene

Genes around SUPV3L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUPV3L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUPV3L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPV3L1 Gene

Proteins for SUPV3L1 Gene

  • Protein details for SUPV3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYB8-SUV3_HUMAN
    Recommended name:
    ATP-dependent RNA helicase SUPV3L1, mitochondrial
    Protein Accession:
    Q8IYB8
    Secondary Accessions:
    • A8K301
    • O43630

    Protein attributes for SUPV3L1 Gene

    Size:
    786 amino acids
    Molecular mass:
    87991 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homodimer; in free form. Component of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer containing 2 copies of SUPV3L1 and 3 copies of PNPT1. Interacts with LAMTOR5/HBXIP, WRN and BLM.

    Three dimensional structures from OCA and Proteopedia for SUPV3L1 Gene

neXtProt entry for SUPV3L1 Gene

Selected DME Specific Peptides for SUPV3L1 Gene

Q8IYB8:
  • PGDCIVCFSK
  • DAIGMGLNL
  • RHAKQIFP
  • SRQIEIRGLE
  • DPARGWAWTRALLGLCAEE
  • LPPGTKL
  • DVGAELTRPLDK
  • GPTNSGKTYHA
  • ALQIAGRAGRF
  • TTGEEVEV
  • CGPLKLLA
  • ARQYSRNEP
  • GLDARLFHQAF
  • RYVFCTAP
  • CKILVATD
  • PCDLVTGEER
  • DDLRKISDLR
  • EQIEMFAYHLP
  • VIDEIQM

Post-translational modifications for SUPV3L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SUPV3L1 Gene

Domains & Families for SUPV3L1 Gene

Gene Families for SUPV3L1 Gene

Protein Domains for SUPV3L1 Gene

Suggested Antigen Peptide Sequences for SUPV3L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYB8

UniProtKB/Swiss-Prot:

SUV3_HUMAN :
  • Belongs to the helicase family.
Family:
  • Belongs to the helicase family.
genes like me logo Genes that share domains with SUPV3L1: view

Function for SUPV3L1 Gene

Molecular function for SUPV3L1 Gene

GENATLAS Biochemistry:
yeast mitochondrial protein homolog,putative ATP-dependent RNA helicase
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=41.9 uM for ATP {ECO:0000269 PubMed:12466530, ECO:0000269 PubMed:15096047}; pH dependence: Optimum pH is 5.0. {ECO:0000269 PubMed:12466530, ECO:0000269 PubMed:15096047}; Temperature dependence: Optimum temperature is 30 degrees Celsius. {ECO:0000269 PubMed:12466530, ECO:0000269 PubMed:15096047};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Helicase activity toward DNA substrate is inhibited by micromolar concentrations of 5,6-dichloro-1-(beta-D-ribofuranosyl)benzotriazole (DRBT) and 4,5,6,7-tetrabromobenzotriazole (TBBT). Helicase activity toward RNA substrate is inhibited by elevated concentrations of TBBT. Inhibited by some ring-expanded nucleoside analogs.
UniProtKB/Swiss-Prot Function:
Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3 overhang double-stranded RNA with a 3-to-5 directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5-to-3 direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.

Enzyme Numbers (IUBMB) for SUPV3L1 Gene

Gene Ontology (GO) - Molecular Function for SUPV3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IMP 12466530
GO:0003678 DNA helicase activity IMP 12466530
GO:0003723 RNA binding IDA,TAS 22658674
GO:0003725 double-stranded RNA binding IDA 19509288
GO:0004004 ATP-dependent RNA helicase activity IDA 19509288
genes like me logo Genes that share ontologies with SUPV3L1: view
genes like me logo Genes that share phenotypes with SUPV3L1: view

Animal Models for SUPV3L1 Gene

MGI Knock Outs for SUPV3L1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SUPV3L1

CRISPR Products

miRNA for SUPV3L1 Gene

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUPV3L1 Gene

Localization for SUPV3L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUPV3L1 Gene

Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUPV3L1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SUPV3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17352692
GO:0005739 mitochondrion IDA,TAS 17352692
GO:0005759 mitochondrial matrix IDA,IEA 12466530
GO:0042645 mitochondrial nucleoid IDA 18063578
GO:0045025 mitochondrial degradosome IDA 19509288
genes like me logo Genes that share ontologies with SUPV3L1: view

Pathways & Interactions for SUPV3L1 Gene

SuperPathways for SUPV3L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUPV3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000958 mitochondrial mRNA catabolic process IMP 19864255
GO:0000962 positive regulation of mitochondrial RNA catabolic process IMP 19864255
GO:0000965 mitochondrial RNA 3-end processing IMP 19864255
GO:0006310 DNA recombination IMP 17961633
GO:0006401 RNA catabolic process IMP 18678873
genes like me logo Genes that share ontologies with SUPV3L1: view

No data available for Pathways by source and SIGNOR curated interactions for SUPV3L1 Gene

Drugs & Compounds for SUPV3L1 Gene

(5) Drugs for SUPV3L1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
Manganese Approved Nutra 34
Magnesium Nutra 0

(1) Additional Compounds for SUPV3L1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with SUPV3L1: view

Transcripts for SUPV3L1 Gene

Unigene Clusters for SUPV3L1 Gene

Suppressor of var1, 3-like 1 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUPV3L1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2: -
SP3: -
SP4:
SP5: - - - - - - - - -

Relevant External Links for SUPV3L1 Gene

GeneLoc Exon Structure for
SUPV3L1
ECgene alternative splicing isoforms for
SUPV3L1

Expression for SUPV3L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUPV3L1 Gene

Protein differential expression in normal tissues from HIPED for SUPV3L1 Gene

This gene is overexpressed in Nasal epithelium (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUPV3L1 Gene



Protein tissue co-expression partners for SUPV3L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUPV3L1 Gene:

SUPV3L1

SOURCE GeneReport for Unigene cluster for SUPV3L1 Gene:

Hs.106469

mRNA Expression by UniProt/SwissProt for SUPV3L1 Gene:

Q8IYB8-SUV3_HUMAN
Tissue specificity: Broadly expressed.

Evidence on tissue expression from TISSUES for SUPV3L1 Gene

  • Blood(4.2)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with SUPV3L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUPV3L1 Gene

Orthologs for SUPV3L1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUPV3L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUPV3L1 34 35
  • 99.79 (n)
cow
(Bos Taurus)
Mammalia SUPV3L1 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUPV3L1 34 35
  • 90.33 (n)
rat
(Rattus norvegicus)
Mammalia Supv3l1 34
  • 84.65 (n)
mouse
(Mus musculus)
Mammalia Supv3l1 34 16 35
  • 84.53 (n)
oppossum
(Monodelphis domestica)
Mammalia SUPV3L1 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUPV3L1 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUPV3L1 34 35
  • 70.77 (n)
lizard
(Anolis carolinensis)
Reptilia SUPV3L1 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia supv3l1 34
  • 70.54 (n)
Str.10077 34
zebrafish
(Danio rerio)
Actinopterygii supv3l1 34 35
  • 68.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9791 36 34 35
  • 57.25 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003508 34
  • 56.78 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_C08F8.2 34
  • 53.61 (n)
C08F8.2 36 35
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUV3 35 37
  • 28 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G39840 34
  • 52.39 (n)
rice
(Oryza sativa)
Liliopsida Os04g0459800 34
  • 51.25 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToOne
Species where no ortholog for SUPV3L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUPV3L1 Gene

ENSEMBL:
Gene Tree for SUPV3L1 (if available)
TreeFam:
Gene Tree for SUPV3L1 (if available)

Paralogs for SUPV3L1 Gene

No data available for Paralogs for SUPV3L1 Gene

Variants for SUPV3L1 Gene

Sequence variations from dbSNP and Humsavar for SUPV3L1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000257126 -- 69,188,785(+) TGAGC(A/C)ACCAT intron-variant
rs1000284022 -- 69,178,999(+) TAACG(C/G/T)GTACT upstream-variant-2KB
rs1000310878 -- 69,189,070(+) TCTGT(C/G)CTCTA intron-variant
rs1000329348 -- 69,185,314(+) TATTG(C/G)TTGTC intron-variant
rs1000543102 -- 69,191,159(+) TCCAG(A/G)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUPV3L1 Gene

Variant ID Type Subtype PubMed ID
esv3891855 CNV loss 25118596
nsv508589 CNV deletion 20534489

Variation tolerance for SUPV3L1 Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUPV3L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUPV3L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUPV3L1 Gene

Disorders for SUPV3L1 Gene

Relevant External Links for SUPV3L1

Genetic Association Database (GAD)
SUPV3L1
Human Genome Epidemiology (HuGE) Navigator
SUPV3L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUPV3L1

No disorders were found for SUPV3L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUPV3L1 Gene

Publications for SUPV3L1 Gene

  1. Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP. (PMID: 16176273) Minczuk M. … Stepien P.P. (FEBS J. 2005) 2 3 4 22 64
  2. Down-regulation of human RNA/DNA helicase SUV3 induces apoptosis by a caspase- and AIF-dependent pathway. (PMID: 17352692) Szczesny R.J. … Stepien P.P. (Biol. Cell 2007) 3 4 22 64
  3. Regulation of the human Suv3 helicase on DNA by inorganic cofactors. (PMID: 25446650) VenA … Stevnsner T. (Biochimie 2015) 2 3 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance. (PMID: 19864255) Szczesny R.J. … Stepien P.P. (Nucleic Acids Res. 2010) 3 4 64

Products for SUPV3L1 Gene

Sources for SUPV3L1 Gene

Content
Loading form....