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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SUPV3L1 Gene

protein-coding GIFtS: 54
GCID: GC10P070939

suppressor of var1, 3-like 1 (S. cerevisiae)

(Previous name: suppressor of var1 (S.cerevisiae) 3-like 1 )

Explore 7 diseases affiliated with
SUPV3L1 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Suppressor Of Var1, 3-Like 1 (S. Cerevisiae)¹ ²		ATP-Dependent RNA Helicase SUPV3L1, Mitochondrial²
SUV3¹ ² ³		Suppressor Of Var1, 3-Like 1(SUV3)²
Suppressor Of Var1 3-Like Protein 1² ³		EC 3.6.4.13³
SUV3-Like Protein 1² ³		EC 3.6.1⁸
Suppressor Of Var1 (S.Cerevisiae) 3-Like 1¹

External Ids:	HGNC: 11471¹	Entrez Gene: 6832²	Ensembl: ENSG00000156502⁷	OMIM: 605122⁵	UniProtKB: Q8IYB8³

Export aliases for SUPV3L1 gene to outside databases

Previous GC identifers: GC10P069751 GC10P070026 GC10P070832 GC10P070284 GC10P070609 GC10P064939

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SUV3_HUMAN, Q8IYB8

Function: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO)

complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner.

ATPase and ATP-dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA

heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the

stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing

intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis.

Associates with mitochondrial DNA

Gene Wiki entry for SUPV3L1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SUPV3L1 gene promoter:
p53 ATF-2 MEF-2 Nkx2-5 AREB6 MEF-2A POU2F1 POU2F1a aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SUPV3L1 promoter sequence

Search SABiosciences Chromatin IP Primers for SUPV3L1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUPV3L1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.1

SUPV3L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUPV3L1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P070939: view genomic region (about GC identifiers)

Start:	70,939,988 bp from pter	End:	70,968,855 bp from pter
Size:	28,868 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SUV3_HUMAN, Q8IYB8 (See protein sequence)

Recommended Name: ATP-dependent RNA helicase SUPV3L1, mitochondrial precursor

Size: 786 amino acids; 87991 Da

Cofactor: Magnesium or manganese

Subunit: Homodimer; in free form. Component of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer

containing 2 copies of SUPV3L1 and 3 copies of PNPT1. Interacts with HBXIP, WRN and BLM

Subcellular location: Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid

2 PDB 3D structures from and Proteopedia for SUPV3L1:

3RC3 (3D)

3RC8 (3D)

Secondary accessions: A8K301 O43630

Explore the universe of human proteins at neXtProt for SUPV3L1: NX_Q8IYB8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IYB8

4/19 DME Specific Peptides for SUPV3L1 (Q8IYB8) (see all 19)

VIDEIQM

LPPGTKL

CGPLKLLA

RHAKQIFP

SUPV3L1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003162.2

ENSEMBL proteins:

ENSP00000352678 ENSP00000409072

Human Recombinant Protein Products for SUPV3L1:

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	Novus Biologicals SUPV3L1 Protein Novus Biologicals SUPV3L1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SUPV3L1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	17352692
GO:0005739	mitochondrion	IDA	19864255
GO:0005759	mitochondrial matrix	IDA	12466530
GO:0042645	mitochondrial nucleoid	IDA	18063578
GO:0045025	mitochondrial degradosome	IDA	19509288

SUPV3L1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SUPV3L1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SUPV3L1 for domains About GeneDecksing

2 InterPro domains/families:

IPR022192 SUV3_C

IPR001650 Helicase_C

Graphical View of Domain Structure for InterPro Entry Q8IYB8

ProtoNet protein and cluster: Q8IYB8

UniProtKB/Swiss-Prot: SUV3_HUMAN, Q8IYB8

Similarity: Belongs to the helicase family

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SUV3_HUMAN, Q8IYB8

Function: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO)

complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner.

ATPase and ATP-dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA

heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the

stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing

intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis.

Associates with mitochondrial DNA

Catalytic activity: ATP + H(2)O = ADP + phosphate

Enzyme regulation: Helicase activity toward DNA substrate is inhibited by micromolar concentrations of

5,6-dichloro-1-(beta-D-ribofuranosyl)benzotriazole (DRBT) and 4,5,6,7-tetrabromobenzotriazole (TBBT). Helicase

activity toward RNA substrate is inhibited by elevated concentrations of TBBT. Inhibited by some ring-expanded

nucleoside analogs

Biophysicochemical properties: Kinetic parameters: KM=41.9 uM for ATP; pH dependence: Optimum pH is 5.0; Temperature

dependence: Optimum temperature is 30 degrees Celsius;

Genatlas biochemistry entry for SUPV3L1:

yeast mitochondrial protein homolog,putative ATP-dependent RNA helicase

Enzyme Numbers (IUBMB): EC 3.6.1² EC 3.6.4.13¹

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IMP	12466530
GO:0003678	DNA helicase activity	IMP	12466530
GO:0003723	RNA binding	TAS	9925937
GO:0003725	double-stranded RNA binding	IDA	19509288

SUPV3L1 for ontologies About GeneDecksing

Phenotypes:
15/20 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Supv3l1) (see all 20):

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial
digestive/alimentary	embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear
hematopoietic system	immune system	integument	mortality/aging	muscle

SUPV3L1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for SUPV3L1: Supv3l1^tm2.3Jkl Supv3l1^tm2.2Jkl

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SUPV3L1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPV3L1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SUPV3L1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/822 Interacting proteins for SUPV3L1 (Q8IYB8^{2, 3} ENSP00000352678⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 822)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
WDR5	P61964²^,³	MINT-7945693 I2D: score=4
EIF2S3	P41091²^,³	MINT-7945693 I2D: score=1
GCN1L1	Q92616²^,³	MINT-7945693 I2D: score=1
PRKAG1	P54619²^,³	MINT-7945693 I2D: score=1
PSMD2	Q13200²^,³	MINT-7945693 I2D: score=1

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000958	mitochondrial mRNA catabolic process	IMP	19864255
GO:0000962	positive regulation of mitochondrial RNA catabolic process	IMP	19864255
GO:0000965	mitochondrial RNA 3'-end processing	IMP	19864255
GO:0006310	DNA recombination	IMP	17961633
GO:0006401	RNA catabolic process	IMP	18678873

SUPV3L1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SUPV3L1

2 HMDB Compounds for SUPV3L1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Magnesium	Magnesium (see all 2)	7439-95-4	--
Manganese	manganese	7439-96-5	--

Search CenterWatch for drugs/clinical trials and news about SUPV3L1 / SUV3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SUPV3L1 gene:

NM_003171.3

Unigene Cluster for SUPV3L1:

Suppressor of var1, 3-like 1 (S. cerevisiae)

Hs.106469 [show with all ESTs]

Unigene Representative Sequence: BC036112

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000359655(uc001jpe.1 uc010qjd.1) ENST00000471069 ENST00000483572

ENST00000422378 ENST00000478227 ENST00000486661 ENST00000497254

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Additional cDNA sequence:

AF042169.1 AK290416.1 AK299670.1 BC036112.1

7 DOTS entries:

DT.412936 DT.101959689 DT.92429438 DT.92429444 DT.100651596 DT.121300968 DT.86993512

24/160 AceView cDNA sequences (see all 160):

AA654266 AW880619 BE784830 BI063321 BQ067555 BP341740 BM460613 BU168259

BI062173 BG741482 BX504619 AW629728 AA910260 BM974990 BM664654 BI062338

AW163267 NM_003171 BC036112 BM450605 CR626248 CD677477 BM703154 AL701777

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SUPV3L1 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17
SP1:									-		-														-
SP2:											-
SP3:									-
SP4:
SP5:									-		-		-		-		-		-		-		-		-

ECgene alternative splicing isoforms for SUPV3L1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SUPV3L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAAACAGC

About this image
See SUPV3L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SUPV3L1

SOURCE GeneReport for Unigene cluster: Hs.106469

UniProtKB/Swiss-Prot: SUV3_HUMAN, Q8IYB8

Tissue specificity: Broadly expressed

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPV3L1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUPV3L1 gene from 9/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Supv3l1^{1 , 5}	suppressor of var1, 3-like 1 (S. cerevisiae)^{1, 5}	85.05(n)¹ 88.69(a)¹		10 (32.40 cM)⁵ 338359¹ NM_181423.2¹ NP_852088.1¹ 62429209⁵
chicken (Gallus gallus)	Aves	SUPV3L1¹	suppressor of var1, 3-like 1 (S. cerevisiae)	70.36(n) 72.2(a)		423697 NM_001006498.1 NP_001006498.1
lizard (Anolis carolinensis)	Reptilia	SUPV3L1⁶	--	69(a)	1 ↔ 1	GL343215.1(2010885-2034522)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.10077²	Transcribed sequence with weak similarity to protein more	77.98(n)		BX738835.1
zebrafish (Danio rerio)	Actinopterygii	AW154428.1²	--	69.14(n)		AW154428.1
fruit fly (Drosophila melanogaster)	Insecta	CG9791^{1 , 3}	ATP dependent RNA helicase³ CG9791¹	60(a)³ 57.25(n)¹ 61.45(a)¹		82A4³ 40543¹ NM_141195.3¹ NP_649452.3¹
worm (Caenorhabditis elegans)	Secernentea	C08F8.2³ CELE_C08F8.2¹	ATP-dependent RNA helicase³ Protein C08F8.2¹	50(a)³ 53.81(n)¹ 49.37(a)¹		IV(11149421-11154277)³ 178022¹ NM_001047446.3¹ NP_001040911.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	ATSUV3¹	ATP-dependent RNA helicase, mitochondrial (SUV3)	52.56(n) 45.83(a)		827134 NM_117564.3 NP_193215.2
rice (Oryza sativa)	Liliopsida	Os03g0746500¹	hypothetical protein	52.24(n) 43.29(a)		4334089 NM_001057785.1 NP_001051250.1

ENSEMBL Gene Tree for SUPV3L1 (if available)
TreeFam Gene Tree for SUPV3L1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35217494^1,2	C,F	--	70938021(+)	`TGGACG/ATTGCA`	1	--	us2k¹		4		NA WA	242
rs113692151^1,2	C	--	70938083(+)	`AAAAG-/AAAAAA`	1	--	us2k¹		1		CSA	2
rs11436692^1,2	C	--	70938092(+)	`AAAAA-/AGATTT`	1	--	us2k¹ trp³		0	--	--	--	--
rs139884277^1,2		--	70938223(+)	`CTTGCC/TTCAGT`	1	--	us2k¹		0	--	--	--	--
rs138476682^1,2		--	70938290(+)	`CATCA-/TTGTTTA`	1	--	us2k¹		0	--	--	--	--
rs185272682^1,2		--	70938316(+)	`CATATG/TTAGTC`	1	--	us2k¹		0	--	--	--	--
rs76851381^1,2	F	--	70938446(+)	`TTCCTC/TCCTGC`	1	--	us2k¹		1		NA	120
rs150218967^1,2	C	--	70938509(+)	`TTCTC-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs190121138^1,2		--	70938736(+)	`GAGTAA/GTAAGT`	1	--	us2k¹		0	--	--	--	--
rs181323374^1,2		--	70939002(+)	`TTAGAC/TGGAGT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SUPV3L1 (70939988 - 70968855 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SUPV3L1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SUPV3L1 for disorders           About GeneDecksing

OMIM gene information: 605122    OMIM disorders: --

7 diseases for SUPV3L1:    About MalaCards

west nile virus japanese encephalitis encephalitis hepatitis c

alzheimer's disease hepatitis malaria

Human Genome Epidemiology (HuGE) Navigator: SUPV3L1 (3 documents)

Export disorders for SUPV3L1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SUPV3L1 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with SUPV3L1)

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Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP. (PubMed id 16176273)^{1, 2, 3, 9} Minczuk M....Stepien P.P. (2005)
Down-regulation of human RNA/DNA helicase SUV3 induces apoptosis by a caspase- and AIF-dependent pathway. (PubMed id 17352692)^{1, 2, 9} Szczesny R.J....Stepien P.P. (2007)
Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance. (PubMed id 19864255)^{1, 2} Szczesny R.J....Stepien P.P. (2010)
Human mitochondrial SUV3 and polynucleotide phosphory lase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality. (PubMed id 19509288)^{1, 2} Wang D.D....Lee W.H. (2009)
Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells. (PubMed id 18678873)^{1, 2} Khidr L....Lee W.H. (2008)
The layered structure of human mitochondrial DNA nucleoids. (PubMed id 18063578)^{1, 2} Bogenhagen D.F....Burke S. (2008)
Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality. (PubMed id 17961633)^{1, 2} Pereira M....Stepien P.P. (2007)
Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change. (PubMed id 15096047)^{1, 2} Shu Z.... Lee W.-H. (2004)
Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA. (PubMed id 12466530)^{1, 2} Minczuk M.... Borowski P. (2002)
Assignment1 of SUPV3L1 to human chromosome band 10q22.1 by in situ hybridization. (PubMed id 9925937)^{1, 3} Dmochowska A....Bartnik E. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6832	HGNC: 11471	AceView: SUPV3L1	Ensembl:ENSG00000156502	euGenes: HUgn6832
ECgene: SUPV3L1	H-InvDB: SUPV3L1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SUPV3L1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SUPV3L1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SUPV3L1 gene:
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GeneCards and IP:
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SUPV3L1 Gene

suppressor of var1, 3-like 1 (S. cerevisiae)

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SUPV3L1 Gene

suppressor of var1, 3-like 1 (S. cerevisiae)

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