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SUPV3L1 Gene

protein-coding   GIFtS: 59
GCID: GC10P070939

Suppressor Of Var1, 3-Like 1 (S. Cerevisiae)

(Previous name: suppressor of var1 (S.cerevisiae) 3-like 1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor Of Var1, 3-Like 1 (S. Cerevisiae)1 2     ATP-Dependent RNA Helicase SUPV3L1, Mitochondrial2
Suppressor Of Var1 3-Like Protein 12 3     Suppressor Of Var1, 3-Like 1(SUV3)2
SUV32 3     EC 3.6.4.133
SUV3-Like Protein 12 3     EC 3.6.18
Suppressor Of Var1 (S.Cerevisiae) 3-Like 11     

External Ids:    HGNC: 114711   Entrez Gene: 68322   Ensembl: ENSG000001565027   OMIM: 6051225   UniProtKB: Q8IYB83   

Export aliases for SUPV3L1 gene to outside databases

Previous GC identifers: GC10P069751 GC10P070026 GC10P070832 GC10P070284 GC10P070609 GC10P064939


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SUPV3L1 Gene:
SUPV3L1 (suppressor of var1, 3-like 1 (S. cerevisiae)) is a protein-coding gene. Diseases associated with SUPV3L1 include west nile virus, and japanese encephalitis. GO annotations related to this gene include RNA binding and helicase activity.

UniProtKB/Swiss-Prot: SUV3_HUMAN, Q8IYB8
Function: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome
(mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent
manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and
RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria;
regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non
coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect
cells from apoptosis. Associates with mitochondrial DNA

Gene Wiki entry for SUPV3L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUPV3L1 gene promoter:
         p53   ATF-2   MEF-2   Nkx2-5   AREB6   MEF-2A   POU2F1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUPV3L1 promoter sequence
   Search Chromatin IP Primers for SUPV3L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUPV3L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

SUPV3L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUPV3L1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P070939:  view genomic region     (about GC identifiers)

Start:
70,939,988 bp from pter      End:
70,968,855 bp from pter
Size:
28,868 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SUV3_HUMAN, Q8IYB8 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase SUPV3L1, mitochondrial precursor  
Size: 786 amino acids; 87991 Da
Cofactor: Magnesium or manganese
Subunit: Homodimer; in free form. Component of the mitochondrial degradosome (mtEXO) complex which is a
heteropentamer containing 2 copies of SUPV3L1 and 3 copies of PNPT1. Interacts with LAMTOR5/HBXIP, WRN and BLM
2 PDB 3D structures from and Proteopedia for SUPV3L1:
3RC3 (3D)        3RC8 (3D)    
Secondary accessions: A8K301 O43630

Explore the universe of human proteins at neXtProt for SUPV3L1: NX_Q8IYB8

Explore proteomics data for SUPV3L1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SUPV3L1 (Q8IYB8) (see all 19)
     VIDEIQM  LPPGTKL  CGPLKLLA  RHAKQIFP 


    See SUPV3L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003162.2  
    ENSEMBL proteins: 
     ENSP00000352678   ENSP00000409072  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR022192 SUV3_C
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q8IYB8

    ProtoNet protein and cluster: Q8IYB8

    UniProtKB/Swiss-Prot: SUV3_HUMAN, Q8IYB8
    Similarity: Belongs to the helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    SUPV3L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUV3_HUMAN, Q8IYB8
    Function: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome
    (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent
    manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and
    RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria;
    regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non
    coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect
    cells from apoptosis. Associates with mitochondrial DNA
    Catalytic activity: ATP + H(2)O = ADP + phosphate
    Enzyme regulation: Helicase activity toward DNA substrate is inhibited by micromolar concentrations of
    5,6-dichloro-1-(beta-D-ribofuranosyl)benzotriazole (DRBT) and 4,5,6,7-tetrabromobenzotriazole (TBBT). Helicase
    activity toward RNA substrate is inhibited by elevated concentrations of TBBT. Inhibited by some ring-expanded
    nucleoside analogs
    Biophysicochemical properties: Kinetic parameters: KM=41.9 uM for ATP; pH dependence: Optimum pH is 5.0;
    Temperature dependence: Optimum temperature is 30 degrees Celsius;

         Genatlas biochemistry entry for SUPV3L1:
    yeast mitochondrial protein homolog,putative ATP-dependent RNA helicase

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IMP12466530
    GO:0003678DNA helicase activity IMP12466530
    GO:0003723RNA binding TAS9925937
    GO:0003725double-stranded RNA binding IDA19509288
         
    SUPV3L1 for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Supv3l1) (see all 21):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear 
     hematopoietic system  immune system  integument  mortality/aging  muscle 

    SUPV3L1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SUPV3L1: Supv3l1tm2.3Jkl Supv3l1tm1Whle Supv3l1tm2.2Jkl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUPV3L1
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    miRNA
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    miRTarBase miRNAs that target SUPV3L1:
    hsa-mir-320a (MIRT044646), hsa-mir-27b-3p (MIRT046174), hsa-mir-200b-3p (MIRT046569), hsa-mir-98-5p (MIRT027436)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPV3L1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SUV3_HUMAN, Q8IYB8: Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17352692
    GO:0005739mitochondrion IDA17352692
    GO:0005759mitochondrial matrix IDA12466530
    GO:0042645mitochondrial nucleoid IDA18063578
    GO:0045025mitochondrial degradosome IDA19509288

    SUPV3L1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SUPV3L1
    Interactions:

        GeneGlobe Interaction Network for SUPV3L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUPV3L1 (Q8IYB82, 3 ENSP000003526784) via UniProtKB, MINT, STRING, and/or I2D (see all 883)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WDR5P619642, 3MINT-7945693 I2D: score=4 
    EIF2S3P410912, 3MINT-7945693 I2D: score=1 
    GCN1L1Q926162, 3MINT-7945693 I2D: score=1 
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    PSMD2Q132002, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000958mitochondrial mRNA catabolic process IMP19864255
    GO:0000962positive regulation of mitochondrial RNA catabolic process IMP19864255
    GO:0000965mitochondrial RNA 3'-end processing IMP19864255
    GO:0006200ATP catabolic process IDA19509288
    GO:0006310DNA recombination IMP17961633

    SUPV3L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for SUPV3L1 (SUV3)

    2 HMDB Compounds for SUPV3L1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SUPV3L1 gene: 
    NM_003171.3  

    Unigene Cluster for SUPV3L1:

    Suppressor of var1, 3-like 1 (S. cerevisiae)
    Hs.106469  [show with all ESTs]
    Unigene Representative Sequence: BC036112
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359655(uc001jpe.1 uc010qjd.1) ENST00000471069 ENST00000483572
    ENST00000422378 ENST00000478227 ENST00000486661 ENST00000497254

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    hsa-miR-450b-5p
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    Additional mRNA sequence: 

    AF042169.1 AK290416.1 AK299670.1 BC036112.1 

    7 DOTS entries:

    DT.412936  DT.101959689  DT.92429438  DT.92429444  DT.100651596  DT.121300968  DT.86993512 

    Selected AceView cDNA sequences (see all 160):

    BM460613 BI062338 CR626248 BM450605 BM974990 BX504619 AA910260 BP341740 
    AL701777 AW163267 BC036112 NM_003171 BI063321 BG741482 BM703154 BU168259 
    BI062173 BI061970 AW880619 BE784830 CD677477 AA654266 BQ067555 BM664654 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SUPV3L1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                          -     -                                         -                                                         
    SP2:                                -                                                                                                   
    SP3:                          -                                                                                                         
    SP4:                                                                                                                                    
    SP5:                          -     -     -     -     -     -     -     -     -                                                         


    ECgene alternative splicing isoforms for SUPV3L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SUPV3L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAAACAGC
    SUPV3L1 Expression
    About this image


    SUPV3L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    SUPV3L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUPV3L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.106469

    UniProtKB/Swiss-Prot: SUV3_HUMAN, Q8IYB8
    Tissue specificity: Broadly expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPV3L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUPV3L1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Supv3l11 , 5 suppressor of var1, 3-like 1 (S. cerevisiae)1, 5 84.53(n)1
    87.92(a)1
      10 (32.40 cM)5
    3383591  NM_181423.21  NP_852088.11 
     624292095 
    chicken
    (Gallus gallus)
    Aves SUPV3L11 suppressor of var1, 3-like 1 (S. cerevisiae) 70.77(n)
    73.03(a)
      423697  NM_001006498.1  NP_001006498.1 
    lizard
    (Anolis carolinensis)
    Reptilia SUPV3L16
    suppressor of var1, 3-like 1 (S. cerevisiae)
    69(a)
    1 ↔ 1
    GL343215.1(2010885-2036827)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.100772 Transcribed sequence with weak similarity to protein more 77.98(n)    BX738835.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AW154428.12   -- 69.14(n)    AW154428.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97911 , 3 ATP dependent RNA helicase3
    CG97911
    60(a)3
    57.25(n)1
    61.45(a)1
      82A43
    405431  NM_141195.41  NP_649452.31 
    worm
    (Caenorhabditis elegans)
    Secernentea C08F8.23
    CELE_C08F8.21
    ATP-dependent RNA helicase3
    CELE_C08F8.21
    50(a)3
    53.61(n)1
    49.69(a)1
      IV(11149421-11154277)3
    1780221  NM_001047447.21  NP_001040912.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SUV3(YPL029W)4 ATP-dependent RNA helicase, component of the mitochondrial more   --   16(495506-497719) 856078  NP_015296.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G398401 AT5G39840 52.39(n)
    48.1(a)
      833980  NM_123347.1  NP_198800.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g04598001 Os04g0459800 51.25(n)
    48.39(a)
      4336047  NM_001059522.1  NP_001052987.1 


    ENSEMBL Gene Tree for SUPV3L1 (if available)
    TreeFam Gene Tree for SUPV3L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SUPV3L1 (see all 750)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352174941,2
    C,F--70938021(+) TGGACG/ATTGCA 1 -- us2k14Minor allele frequency- A:0.17NA WA 242
    rs114366921,2
    C--70938091(+) AAAAA-/AGATTT 1 -- us2k1 trp31Minor allele frequency- A:0.50CSA 2
    rs1398842771,2
    --70938223(+) CTTGCC/TTCAGT 1 -- us2k10--------
    rs1384766821,2
    C--70938290(+) CATCA-/TTGTTTA 1 -- us2k10--------
    rs1852726821,2
    --70938316(+) CATATG/TTAGTC 1 -- us2k10--------
    rs768513811,2
    F--70938446(+) TTCCTC/TCCTGC 1 -- us2k11Minor allele frequency- T:0.04NA 120
    rs1502189671,2
    C--70938509(+) TTCTC-/AAAAAA 1 -- us2k10--------
    rs1901211381,2
    --70938736(+) GAGTAA/GTAAGT 1 -- us2k10--------
    rs1813233741,2
    --70939002(+) TTAGAC/TGGAGT 1 -- us2k10--------
    rs1863398061,2
    --70939033(+) GGAGAG/TCAGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SUPV3L1 (70939988 - 70968855 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SUPV3L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508589CNV Loss20534489
    nsv895694CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUPV3L1
    DNA2.0 Custom Variant and Variant Library Synthesis for SUPV3L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605122    OMIM disorders: --

    13 diseases for SUPV3L1:    
    About MalaCards
    west nile virus    japanese encephalitis    smallpox    encephalitis
    hepatitis c    tonsillitis    alzheimer's disease    hepatitis
    thyroiditis    cerebritis    malaria    endotheliitis
    prostatitis


    SUPV3L1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SUPV3L1
    Human Genome Epidemiology (HuGE) Navigator: SUPV3L1 (3 documents)

    Export disorders for SUPV3L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUPV3L1 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with SUPV3L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP. (PubMed id 16176273)1, 2, 3, 9 Minczuk M.... Stepien P.P. (FEBS J. 2005)
    2. Down-regulation of human RNA/DNA helicase SUV3 induces apoptosis by a caspase- and AIF-dependent pathway. (PubMed id 17352692)1, 2, 9 Szczesny R.J....Stepien P.P. (Biol. Cell 2007)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance. (PubMed id 19864255)1, 2 Szczesny R.J.... Stepien P.P. (Nucleic Acids Res. 2010)
    5. Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330- kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality. (PubMed id 19509288)1, 2 Wang D.D.... Lee W.H. (J. Biol. Chem. 2009)
    6. Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells. (PubMed id 18678873)1, 2 Khidr L.... Lee W.H. (J. Biol. Chem. 2008)
    7. The layered structure of human mitochondrial DNA nucleoids. (PubMed id 18063578)1, 2 Bogenhagen D.F.... Burke S. (J. Biol. Chem. 2008)
    8. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PubMed id 17373700)1, 4 Morgan A.R....Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    9. Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality. (PubMed id 17961633)1, 2 Pereira M.... Stepien P.P. (Mech. Ageing Dev. 2007)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6832 HGNC: 11471 AceView: SUPV3L1 Ensembl:ENSG00000156502 euGenes: HUgn6832
    ECgene: SUPV3L1 H-InvDB: SUPV3L1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SUPV3L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SUPV3L1 gene:
    Search GeneIP for patents involving SUPV3L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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