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Aliases for SUPT7L Gene

Aliases for SUPT7L Gene

  • Suppressor Of Ty 7 (S. Cerevisiae)-Like 2 3
  • SPTF-Associated Factor 65 Gamma 3 4
  • Adenocarcinoma Antigen ART1 3 4
  • Suppressor Of Ty 7-Like 3 4
  • STAF65gamma 3 4
  • KIAA0764 4 6
  • STAF65G 3 6
  • SUPT7H 3 6
  • SPT7L 3 6
  • STAGA Complex 65 Gamma Subunit 3
  • STAGA Complex 65 Subunit Gamma 3
  • STAF65(Gamma) 3
  • STAF65 3

External Ids for SUPT7L Gene

Summaries for SUPT7L Gene

Entrez Gene Summary for SUPT7L Gene

  • SUPT7L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]

GeneCards Summary for SUPT7L Gene

SUPT7L (Suppressor Of Ty 7 (S. Cerevisiae)-Like) is a Protein Coding gene. Diseases associated with SUPT7L include adenocarcinoma. Among its related pathways are Validated targets of C-MYC transcriptional activation and RNA Polymerase I Promoter Opening. GO annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity.

Gene Wiki entry for SUPT7L Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT7L Gene

Genomics for SUPT7L Gene

Genomic Location for SUPT7L Gene

Start:
27,650,809 bp from pter
End:
27,663,973 bp from pter
Size:
13,165 bases
Orientation:
Minus strand

Genomic View for SUPT7L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUPT7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPT7L Gene

Regulatory Elements for SUPT7L Gene

Proteins for SUPT7L Gene

  • Protein details for SUPT7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94864-ST65G_HUMAN
    Recommended name:
    STAGA complex 65 subunit gamma
    Protein Accession:
    O94864
    Secondary Accessions:
    • B4E3W3
    • Q6IB21
    • Q9H2T6

    Protein attributes for SUPT7L Gene

    Size:
    414 amino acids
    Molecular mass:
    46193 Da
    Quaternary structure:
    • Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, SUPT7L, GCN5L2, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12 and TAF9.
    SequenceCaution:
    • Sequence=BAA34484.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SUPT7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUPT7L Gene

Proteomics data for SUPT7L Gene at MOPED

Post-translational modifications for SUPT7L Gene

Other Protein References for SUPT7L Gene

No data available for DME Specific Peptides for SUPT7L Gene

Domains for SUPT7L Gene

Protein Domains for SUPT7L Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SUPT7L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SUPT7L Gene

Function for SUPT7L Gene

Gene Ontology (GO) - Molecular Function for SUPT7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0005515 protein binding IPI 15870280
genes like me logo Genes that share ontologies with SUPT7L: view

Phenotypes for SUPT7L Gene

MGI mutant phenotypes for SUPT7L:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SUPT7L: view

miRNA for SUPT7L Gene

miRTarBase miRNAs that target SUPT7L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SUPT7L Gene

Localization for SUPT7L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUPT7L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUPT7L Gene COMPARTMENTS Subcellular localization image for SUPT7L gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SUPT7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10987294
GO:0030914 STAGA complex IDA 11564863
genes like me logo Genes that share ontologies with SUPT7L: view

Pathways for SUPT7L Gene

genes like me logo Genes that share pathways with SUPT7L: view

Pathways by source for SUPT7L Gene

Gene Ontology (GO) - Biological Process for SUPT7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0043966 histone H3 acetylation IDA 11564863
GO:0051457 maintenance of protein location in nucleus IDA 15870280
genes like me logo Genes that share ontologies with SUPT7L: view

Transcripts for SUPT7L Gene

Unigene Clusters for SUPT7L Gene

Suppressor of Ty 7 (S. cerevisiae)-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUPT7L Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g ^ 4a · 4b ^ 5 ^ 6
SP1: - - - - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5:
SP6:
SP7:

Relevant External Links for SUPT7L Gene

GeneLoc Exon Structure for
SUPT7L
ECgene alternative splicing isoforms for
SUPT7L

Expression for SUPT7L Gene

mRNA expression in normal human tissues for SUPT7L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUPT7L Gene

SOURCE GeneReport for Unigene cluster for SUPT7L Gene Hs.6232

mRNA Expression by UniProt/SwissProt for SUPT7L Gene

O94864-ST65G_HUMAN
Tissue specificity: Expressed at high levels in adenocarcinomas and gliomas and low in esophageal cancers and malignant hematological disease. Also expressed at high level in the thymus, low in peripheral blood mononuclear cells, and lowest in the stomach, small intestine, and skeletal muscle
genes like me logo Genes that share expressions with SUPT7L: view

Orthologs for SUPT7L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUPT7L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUPT7L 36
  • 99.6 (n)
  • 99.51 (a)
SUPT7L 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUPT7L 36
  • 91.1 (n)
  • 97.09 (a)
SUPT7L 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 98 (a)
OneToMany
-- 37
  • 97 (a)
OneToMany
-- 37
  • 61 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
LOC475708 36
  • 93.28 (n)
  • 98.54 (a)
mouse
(Mus musculus)
Mammalia Supt7l 36
  • 90.86 (n)
  • 95.87 (a)
Supt7l 16
Supt7l 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUPT7L 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUPT7L 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Supt7l 36
  • 90.53 (n)
  • 96.36 (a)
chicken
(Gallus gallus)
Aves SUPT7L 36
  • 78.88 (n)
  • 87.14 (a)
SUPT7L 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUPT7L 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6149 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76026 36
supt7l 36
  • 73.14 (n)
  • 79.13 (a)
zebrafish
(Danio rerio)
Actinopterygii supt7l 36
  • 67.65 (n)
  • 72.73 (a)
supt7l 37
  • 70 (a)
OneToOne
Species with no ortholog for SUPT7L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUPT7L Gene

ENSEMBL:
Gene Tree for SUPT7L (if available)
TreeFam:
Gene Tree for SUPT7L (if available)

Paralogs for SUPT7L Gene

No data available for Paralogs for SUPT7L Gene

Variants for SUPT7L Gene

Sequence variations from dbSNP and Humsavar for SUPT7L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs15670 -- 27,652,371(-) TGTAA(A/T)ATTTA utr-variant-3-prime
rs1801884 -- 27,653,459(-) TTGTC(A/C)AGACC utr-variant-3-prime
rs1801885 -- 27,653,287(-) CACAA(A/C)CAAGC utr-variant-3-prime
rs2091541 -- 27,657,968(+) ATTTT(G/T)ATCAC intron-variant
rs3792250 -- 27,658,963(-) TACCT(C/G)GTTTT intron-variant

Relevant External Links for SUPT7L Gene

HapMap Linkage Disequilibrium report
SUPT7L

No data available for Structural Variations from Database of Genomic Variants (DGV) for SUPT7L Gene

Disorders for SUPT7L Gene

(1) MalaCards Diseases for SUPT7L Gene

Search for SUPT7L Gene in MalaCards »
genes like me logo Genes that share disorders with SUPT7L: view

No data available for UniProtKB/Swiss-Prot for SUPT7L Gene

Publications for SUPT7L Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PMID: 11564863) Martinez E. … Roeder R.G. (Mol. Cell. Biol. 2001) 2 3 4
  3. A new tumor-rejection antigen recognized by cytotoxic T lymphocytes infiltrating into a lung adenocarcinoma. (PMID: 10987294) Nishizaka S. … Shichijo S. (Cancer Res. 2000) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SUPT7L Gene

Sources for SUPT7L Gene

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