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Aliases for SUPT7L Gene

Aliases for SUPT7L Gene

  • SPT7-Like STAGA Complex Gamma Subunit 2 3 5
  • Suppressor Of Ty 7 (S. Cerevisiae)-Like 2 3
  • SPTF-Associated Factor 65 Gamma 3 4
  • Adenocarcinoma Antigen ART1 3 4
  • Suppressor Of Ty 7-Like 3 4
  • STAF65gamma 3 4
  • STAGA Complex 65 Gamma Subunit 3
  • STAF65(Gamma) 3
  • KIAA0764 4
  • STAF65G 3
  • STAF65 3
  • SUPT7H 3
  • SPT7L 3

External Ids for SUPT7L Gene

Previous GeneCards Identifiers for SUPT7L Gene

  • GC02M027786
  • GC02M027727
  • GC02M027873
  • GC02M027614

Summaries for SUPT7L Gene

Entrez Gene Summary for SUPT7L Gene

  • SUPT7L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]

GeneCards Summary for SUPT7L Gene

SUPT7L (SPT7-Like STAGA Complex Gamma Subunit) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional activation and Chromatin organization. GO annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity.

Gene Wiki entry for SUPT7L Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT7L Gene

Genomics for SUPT7L Gene

Regulatory Elements for SUPT7L Gene

Promoters for SUPT7L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUPT7L on UCSC Golden Path with GeneCards custom track

Genomic Location for SUPT7L Gene

Chromosome:
2
Start:
27,642,568 bp from pter
End:
27,663,973 bp from pter
Size:
21,406 bases
Orientation:
Minus strand

Genomic View for SUPT7L Gene

Genes around SUPT7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUPT7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUPT7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPT7L Gene

Proteins for SUPT7L Gene

  • Protein details for SUPT7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94864-ST65G_HUMAN
    Recommended name:
    STAGA complex 65 subunit gamma
    Protein Accession:
    O94864
    Secondary Accessions:
    • B4E3W3
    • Q6IB21
    • Q9H2T6

    Protein attributes for SUPT7L Gene

    Size:
    414 amino acids
    Molecular mass:
    46193 Da
    Quaternary structure:
    • Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, SUPT7L, GCN5L2, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12 and TAF9.
    SequenceCaution:
    • Sequence=BAA34484.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SUPT7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUPT7L Gene

Proteomics data for SUPT7L Gene at MOPED

Post-translational modifications for SUPT7L Gene

No data available for DME Specific Peptides for SUPT7L Gene

Domains & Families for SUPT7L Gene

Gene Families for SUPT7L Gene

Protein Domains for SUPT7L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SUPT7L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SUPT7L: view

No data available for UniProtKB/Swiss-Prot for SUPT7L Gene

Function for SUPT7L Gene

Phenotypes for SUPT7L Gene

genes like me logo Genes that share phenotypes with SUPT7L: view

Animal Models for SUPT7L Gene

MGI Knock Outs for SUPT7L:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUPT7L Gene

Localization for SUPT7L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUPT7L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUPT7L Gene COMPARTMENTS Subcellular localization image for SUPT7L gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for SUPT7L Gene

Pathways & Interactions for SUPT7L Gene

genes like me logo Genes that share pathways with SUPT7L: view

Pathways by source for SUPT7L Gene

Gene Ontology (GO) - Biological Process for SUPT7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0043966 histone H3 acetylation IDA 11564863
GO:0051457 maintenance of protein location in nucleus IDA 15870280
genes like me logo Genes that share ontologies with SUPT7L: view

No data available for SIGNOR curated interactions for SUPT7L Gene

Drugs & Compounds for SUPT7L Gene

No Compound Related Data Available

Transcripts for SUPT7L Gene

Unigene Clusters for SUPT7L Gene

Suppressor of Ty 7 (S. cerevisiae)-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUPT7L Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g ^ 4a · 4b ^ 5 ^ 6
SP1: - - - - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5:
SP6:
SP7:

Relevant External Links for SUPT7L Gene

GeneLoc Exon Structure for
SUPT7L
ECgene alternative splicing isoforms for
SUPT7L

Expression for SUPT7L Gene

mRNA expression in normal human tissues for SUPT7L Gene

Protein differential expression in normal tissues from HIPED for SUPT7L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.2) and CD4 Tcells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUPT7L Gene



SOURCE GeneReport for Unigene cluster for SUPT7L Gene Hs.6232

mRNA Expression by UniProt/SwissProt for SUPT7L Gene

O94864-ST65G_HUMAN
Tissue specificity: Expressed at high levels in adenocarcinomas and gliomas and low in esophageal cancers and malignant hematological disease. Also expressed at high level in the thymus, low in peripheral blood mononuclear cells, and lowest in the stomach, small intestine, and skeletal muscle.
genes like me logo Genes that share expression patterns with SUPT7L: view

Protein tissue co-expression partners for SUPT7L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SUPT7L Gene

Orthologs for SUPT7L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUPT7L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUPT7L 35
  • 91.1 (n)
  • 97.09 (a)
SUPT7L 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC475708 35
  • 93.28 (n)
  • 98.54 (a)
-- 36
  • 98 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Supt7l 35
  • 90.86 (n)
  • 95.87 (a)
Supt7l 16
Supt7l 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUPT7L 35
  • 99.6 (n)
  • 99.51 (a)
SUPT7L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Supt7l 35
  • 90.53 (n)
  • 96.36 (a)
oppossum
(Monodelphis domestica)
Mammalia SUPT7L 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUPT7L 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUPT7L 35
  • 78.88 (n)
  • 87.14 (a)
SUPT7L 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUPT7L 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76026 35
supt7l 35
  • 73.14 (n)
  • 79.13 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6149 35
zebrafish
(Danio rerio)
Actinopterygii supt7l 35
  • 67.65 (n)
  • 72.73 (a)
supt7l 36
  • 70 (a)
OneToOne
Species with no ortholog for SUPT7L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUPT7L Gene

ENSEMBL:
Gene Tree for SUPT7L (if available)
TreeFam:
Gene Tree for SUPT7L (if available)

Paralogs for SUPT7L Gene

No data available for Paralogs for SUPT7L Gene

Variants for SUPT7L Gene

Sequence variations from dbSNP and Humsavar for SUPT7L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs15670 -- 27,652,371(-) TGTAA(A/T)ATTTA intron-variant, utr-variant-3-prime
rs1801884 -- 27,653,459(-) TTGTC(A/C)AGACC nc-transcript-variant, utr-variant-3-prime
rs1801885 -- 27,653,287(-) CACAA(A/C)CAAGC intron-variant, utr-variant-3-prime
rs2091541 -- 27,657,968(+) ATTTT(G/T)ATCAC intron-variant
rs3792250 -- 27,658,963(-) TACCT(C/G)GTTTT intron-variant

Variation tolerance for SUPT7L Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUPT7L Gene

HapMap Linkage Disequilibrium report
SUPT7L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SUPT7L Gene

Disorders for SUPT7L Gene

Relevant External Links for SUPT7L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUPT7L

No disorders were found for SUPT7L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUPT7L Gene

Publications for SUPT7L Gene

  1. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PMID: 11564863) Martinez E. … Roeder R.G. (Mol. Cell. Biol. 2001) 2 3 4 67
  2. The transcriptional repression activity of STAF65I^ is facilitated by promoter tethering and nuclear import of class IIa histone deacetylases. (PMID: 24852358) Hsieh F.S. … Yang W.M. (Biochim. Biophys. Acta 2014) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia. (PMID: 23044487) Holmlund T. … Wallberg A.E. (Leukemia 2013) 3
  5. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PMID: 23382074) Armour S.M. … Sinclair D.A. (Mol. Cell. Biol. 2013) 3

Products for SUPT7L Gene

Sources for SUPT7L Gene

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