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SUPT6H Gene

protein-coding   GIFtS: 60
GCID: GC17P026989

Suppressor Of Ty 6 Homolog (S. Cerevisiae)

(Previous name: suppressor of Ty (S.cerevisiae) 6 homolog)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor Of Ty 6 Homolog (S. Cerevisiae)1 2     Suppressor Of Ty (S.Cerevisiae) 6 Homolog1
Histone Chaperone Suppressor Of Ty62 3     SPT62
Tat-Cotransactivator 2 Protein2 3     emb-52
Tat-CT2 Protein2 3     Transcription Elongation Factor SPT62
SPT6H2 3     KIAA01623
hSPT62 3     

External Ids:    HGNC: 114701   Entrez Gene: 68302   Ensembl: ENSG000001091117   OMIM: 6013335   UniProtKB: Q7KZ853   

Export aliases for SUPT6H gene to outside databases

Previous GC identifers: GC17P026846 GC17P028889 GC17P027134 GC17P027145 GC17P024013 GC17P023197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SUPT6H Gene:
SUPT6H (suppressor of Ty 6 homolog (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include histone binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: SPT6H_HUMAN, Q7KZ85
Function: Transcription elongation factor which binds histone H3 and plays a key role in the regulation of
transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII)
and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear
transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA
by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The
SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes
(such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation,
a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both
class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on
activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program
by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin
interaction of the H3K27 demethylase KDM6A

Gene Wiki entry for SUPT6H Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUPT6H gene promoter:
         AhR   Elk-1   Pax-6   Tal-1beta   Meis-1b   Evi-1   E47   Nkx6-1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUPT6H promoter sequence
   Search Chromatin IP Primers for SUPT6H

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUPT6H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

SUPT6H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUPT6H gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P026989:  view genomic region     (about GC identifiers)

Start:
26,989,109 bp from pter      End:
27,029,697 bp from pter
Size:
40,589 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPT6H_HUMAN, Q7KZ85 (See protein sequence)
Recommended Name: Transcription elongation factor SPT6  
Size: 1726 amino acids; 199073 Da
Subunit: Interacts with RNA polymerase II and the DRB sensitivity-inducing factor complex (DSIF complex), which is
composed of SUPT5H and SUPT4H1. Interacts with human cytomegalovirus/HHV-5 protein UL69. Interacts with KDM6A (By
similarity). Interacts (via SH2 domain) with SETD1A (By similarity). Interacts (via SH2 domain) with POLR2A
phosphorylated at 'Ser-2'. Interacts with IWS1, AICDA and PAAF1. Interacts with histone H2B and H3
Sequence caution: Sequence=AAB18949.1; Type=Frameshift; Positions=988; Sequence=AAC50821.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAH33074.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAA11479.2; Type=Erroneous initiation; Note=Translation
N-terminally shortened;
Secondary accessions: A7E2B4 Q15737 Q6GMQ4 Q7KYW9 Q7LDK4 Q8N526 Q92775 Q96AH3 Q9BTH9 Q9BTI2
Alternative splicing: 3 isoforms:  Q7KZ85-1   Q7KZ85-2   Q7KZ85-3   

Explore the universe of human proteins at neXtProt for SUPT6H: NX_Q7KZ85

Explore proteomics data for SUPT6H at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys402, Lys538, Lys844, Lys1002, Lys1100, Lys1243, Lys1341, Lys1471, Lys1512
  • Modification sites at PhosphoSitePlus

  • See SUPT6H Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003161.2  
    ENSEMBL proteins: 
     ENSP00000319104   ENSP00000338143   ENSP00000464545   ENSP00000465508  

    SUPT6H Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUPT6H

     
    Search eBioscience for Proteins for SUPT6H 

     
    Search antibodies-online for proteins for SUPT6H 

     
    antibodies-online peptides for SUPT6H

    SUPT6H Antibody Products:

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    antibodies-online antibodies for SUPT6H (22 products) 

    SUPT6H Assay Products:

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    Cloud-Clone Corp. ELISAs for SUPT6H
    Cloud-Clone Corp. CLIAs for SUPT6H
    Search eBioscience for ELISAs for SUPT6H 
    antibodies-online kits for SUPT6H (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    Selected InterPro protein domains (see all 14):
     IPR012340 NA-bd_OB-fold
     IPR003029 Rbsml_prot_S1_RNA-bd_dom
     IPR028088 Spt6_HTH_DNA-bd_dom
     IPR023323 Tex-like_dom
     IPR028083 Spt6_acidic_N_dom

    Graphical View of Domain Structure for InterPro Entry Q7KZ85

    ProtoNet protein and cluster: Q7KZ85

    1 Blocks protein domain: IPB003029 RNA binding S1

    UniProtKB/Swiss-Prot: SPT6H_HUMAN, Q7KZ85
    Similarity: Belongs to the SPT6 family
    Similarity: Contains 1 S1 motif domain
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with SUPT6H           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPT6H_HUMAN, Q7KZ85
    Function: Transcription elongation factor which binds histone H3 and plays a key role in the regulation of
    transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII)
    and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear
    transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA
    by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The
    SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes
    (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation,
    a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both
    class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on
    activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program
    by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin
    interaction of the H3K27 demethylase KDM6A

         Genatlas biochemistry entry for SUPT6H:
    putative chromatin structure regulator,yeast spt6 (suppressor of Ty) homolog,ubiquitously expressed,tighly linked
    to WHN

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8786132
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI10933715
    GO:0016788hydrolase activity, acting on ester bonds IEA--
         
    Find genes that share ontologies with SUPT6H           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SUPT6H:
     Decreased G3BP1 protein expres  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability 
     Elongated cells with protrusio 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SUPT6H

    miRNA
    Products:
        
    miRTarBase miRNAs that target SUPT6H:
    hsa-mir-125b-5p (MIRT045937), hsa-mir-10a-5p (MIRT047722), hsa-mir-652-3p (MIRT039536), hsa-mir-615-3p (MIRT039964)

    Block miRNA regulation of human, mouse, rat SUPT6H using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUPT6H (see all 12):
    hsa-miR-200a hsa-miR-877* hsa-miR-141 hsa-miR-135b hsa-miR-1208 hsa-miR-3121-3p hsa-miR-324-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidSUPT6H 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SUPT6H
    Predesigned siRNA for gene silencing in human, mouse, rat SUPT6H

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SUPT6H (NM_003170)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUPT6H

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT6H


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPT6H_HUMAN, Q7KZ85: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8786132

    Find genes that share ontologies with SUPT6H           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SUPT6H
    Interactions:

        Search GeneGlobe Interaction Network for SUPT6H

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUPT6H (Q7KZ851, 2, 3 ENSP000003191044) via UniProtKB, MINT, STRING, and/or I2D (see all 186)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4CP628053, ENSP000003670344I2D: score=4 STRING: ENSP00000367034
    HIST1H4DP628053, ENSP000003432824I2D: score=4 STRING: ENSP00000343282
    HIST1H4KP628053, ENSP000003501594I2D: score=4 STRING: ENSP00000350159
    HIST4H4P628053, ENSP000003507674I2D: score=4 STRING: ENSP00000350767
    HIST1H4FP628053, ENSP000003669744I2D: score=4 STRING: ENSP00000366974
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process ----
    GO:0006338chromatin remodeling NAS8786132
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS8786132
    GO:0006357regulation of transcription from RNA polymerase II promoter ----

    Find genes that share ontologies with SUPT6H           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUPT6H (SPT6H)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SUPT6H gene: 
    NM_003170.3  

    Unigene Cluster for SUPT6H:

    Suppressor of Ty 6 homolog (S. cerevisiae)
    Hs.250429  [show with all ESTs]
    Unigene Representative Sequence: BC150268
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314616(uc002hby.3 uc010crt.3) ENST00000347486 ENST00000577713
    ENST00000584312 ENST00000584285 ENST00000577939 ENST00000581908 ENST00000585230
    ENST00000583972(uc002hbz.1) ENST00000580471 ENST00000581510 ENST00000583340

    miRNA
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    Block miRNA regulation of human, mouse, rat SUPT6H using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUPT6H (see all 12):
    hsa-miR-200a hsa-miR-877* hsa-miR-141 hsa-miR-135b hsa-miR-1208 hsa-miR-3121-3p hsa-miR-324-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidSUPT6H 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SUPT6H (NM_003170)
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      QuantiTect SYBR Green Assays in human, mouse, rat SUPT6H
      QuantiFast Probe-based Assays in human, mouse, rat SUPT6H

    Additional mRNA sequence: 

    AF070532.1 AK126585.1 AL833607.1 BC003692.1 BC003696.1 BC017105.1 BC033074.1 BC073963.1 
    BC136522.1 BC136524.1 BC150268.1 D79984.1 U38623.1 U38658.1 

    22 DOTS entries:

    DT.445520  DT.95319165  DT.99995474  DT.92330717  DT.100792515  DT.91761930  DT.91919349  DT.120921747 
    DT.86855505  DT.91964469  DT.92376278  DT.95229083  DT.95314216  DT.100792514  DT.120921688  DT.120921727 
    DT.91761922  DT.95229085  DT.99981545  DT.102840448  DT.86847634  DT.91870169 

    Selected AceView cDNA sequences (see all 287):

    AL135573 F08860 BI255281 AA373676 AI127150 AI813841 CD364746 AA337050 
    BP365322 AI392835 AI766647 CB123617 BM727344 BM453236 BX480448 D79984 
    CO245384 BC003692 BM727345 BU857632 AF070532 BF873909 AK126585 CD616485 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SUPT6H (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
    SP1:                                                        -                 -                                                                                 
    SP2:                                                        -                 -                 -     -     -     -     -     -     -     -     -     -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34a · 34b ^ 35
    SP1:  -     -                                                                                                   
    SP2:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -               
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SUPT6H

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SUPT6H expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCTCCCCT
    SUPT6H Expression
    About this image


    SUPT6H expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    SUPT6H Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUPT6H Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.250429

    UniProtKB/Swiss-Prot: SPT6H_HUMAN, Q7KZ85
    Tissue specificity: Ubiquitously expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUPT6H gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Supt61 , 5 suppressor of Ty 6 homolog (S. cerevisiae)5
    suppressor of Ty 61
    90.56(n)1
    98.09(a)1
      11 (46.74 cM)5
    209261  NM_009297.21  NP_033323.21 
     782067465 
    chicken
    (Gallus gallus)
    Aves SUPT6H1 suppressor of Ty 6 homolog (S. cerevisiae) 80.91(n)
    93.62(a)
      425418  XM_423183.4  XP_423183.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    89(a)
    67(a)
    many → 1
    many → 1
    AAWZ02039681(126-8086)
    GL344005.1(1833-45675)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146502 Xenopus laevis transcribed sequence with strong similarity to protein refNP_003161.1 (H.sapiens) suppressor of Ty 6 homolog (S. cerevisiae); suppressor of Ty (S.cerevisiae) 6 homolog [Homo sapiens] less 79.12(n)    BJ098459.1 
    zebrafish
    (Danio rerio)
    Actinopterygii supt6h2 suppressor of Ty 6 homolog (S. cerevisiae) 77.98(n)   337866  BC063248.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spt61 , 3 chromatin binding3
    Spt61
    51(a)3
    56.18(n)1
    50.76(a)1
      5E43
    440001  NM_143705.21  NP_651962.21 
    worm
    (Caenorhabditis elegans)
    Secernentea emb-51 emb-5 49.08(n)
    40.38(a)
      175621  NM_065568.3  NP_497969.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPT6(YGR116W)4
    SPT61
    Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region less4
    SPT61
    42.34(n)1
    28.47(a)1
      7(720409-724764)4
    8530111, 4  NP_011631.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GTB11 GTB1 44.58(n)
    33.59(a)
      842855  NM_001084306.2  NP_001077775.1 


    ENSEMBL Gene Tree for SUPT6H (if available)
    TreeFam Gene Tree for SUPT6H (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SUPT6H (see all 760)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882706141,2
    C--26991392(+) GTGGCA/GACACG 1 -- int10--------
    rs602961411,2
    C,F--26991476(+) AGAGAC/TCATGC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1928461101,2
    --26991630(+) TGAAAG/TTTGGC 1 -- int10--------
    rs743360221,2
    F--26991673(+) CTCCTC/GTATGT 1 -- int11Minor allele frequency- G:0.02NA 120
    rs1853386851,2
    --26991791(+) CAAACC/TTTATC 1 -- int10--------
    rs1407420971,2
    --26991797(+) TTATCA/CTCCCG 1 -- int10--------
    rs561470191,2
    C--26991821(+) TGCTCC/TTATCC 1 -- int10--------
    rs1163469101,2
    C--26991868(+) TTGTTC/GTTCTC 1 -- int10--------
    rs1429163511,2
    --26992139(+) TTTCCA/GTGGCC 1 -- int10--------
    rs99164651,2
    C,F,H--26992367(+) TCGCTC/TTTAGA 1 -- int126Minor allele frequency- T:0.26NS EA NA WA CSA 2354

    HapMap Linkage Disequilibrium report for SUPT6H (26989109 - 27029697 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SUPT6H:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv542e199CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUPT6H
    DNA2.0 Custom Variant and Variant Library Synthesis for SUPT6H

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601333    OMIM disorders: --


    Find genes that share disorders with SUPT6H           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SUPT6H (1 document)

    Export disorders for SUPT6H gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUPT6H gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with SUPT6H)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h. (PubMed id 8786132)1, 2, 3, 9 Chiang P.-W.... Kurnit D.M. (Genomics 1996)
    2. Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. (PubMed id 15060154)1, 2, 9 Endoh M.... Handa H. (Mol. Cell. Biol. 2004)
    3. Functional interaction between pleiotropic transactivator pUL69 of human cytomegalovirus and the human homolog of yeast chromatin regulatory protein SPT6. (PubMed id 10933715)1, 2, 9 Winkler M....Stamminger T. (J. Virol. 2000)
    4. Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR. (PubMed id 22316138)1, 2 Nakamura M....Kiernan R. (Retrovirology 2012)
    5. The cellular protein SPT6 is required for efficient replication of human cytomegalovirus. (PubMed id 22171252)1, 2 Cygnar D.... Bresnahan W.A. (J. Virol. 2012)
    6. Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation. (PubMed id 21518874)1, 2 Okazaki I.M....Honjo T. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    7. The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. (PubMed id 19141475)1, 2 Yoh S.M....Jones K.A. (amp 2008)
    8. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. (PubMed id 17234882)1, 2 Yoh S.M....Jones K.A. (amp 2007)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6830 HGNC: 11470 AceView: SUPT6H Ensembl:ENSG00000109111 euGenes: HUgn6830
    ECgene: SUPT6H H-InvDB: SUPT6H

    (According to HUGE)
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    HUGE: KIAA0162

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SUPT6H Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SUPT6H Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SUPT6H gene:
    Search GeneIP for patents involving SUPT6H

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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