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Aliases for SUPT6H Gene

Aliases for SUPT6H Gene

  • SPT6 Homolog, Histone Chaperone 2 3 5
  • Histone Chaperone Suppressor Of Ty6 3 4
  • Tat-Cotransactivator 2 Protein 3 4
  • Tat-CT2 Protein 3 4
  • SPT6H 3 4
  • Suppressor Of Ty 6 Homolog (S. Cerevisiae) 2
  • Suppressor Of Ty (S.Cerevisiae) 6 Homolog 2
  • Suppressor Of Ty 6 Homolog 3
  • KIAA0162 4
  • Emb-5 3
  • HSPT6 4
  • SPT6 3

External Ids for SUPT6H Gene

Previous GeneCards Identifiers for SUPT6H Gene

  • GC17P026846
  • GC17P028889
  • GC17P027134
  • GC17P027145
  • GC17P024013
  • GC17P026989
  • GC17P023197

Summaries for SUPT6H Gene

GeneCards Summary for SUPT6H Gene

SUPT6H (SPT6 Homolog, Histone Chaperone) is a Protein Coding gene. Diseases associated with SUPT6H include Chromosome 17Q11.2 Deletion Syndrome, 1.4Mb. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for SUPT6H Gene

  • Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.

Gene Wiki entry for SUPT6H Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT6H Gene

Genomics for SUPT6H Gene

Regulatory Elements for SUPT6H Gene

Enhancers for SUPT6H Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SUPT6H on UCSC Golden Path with GeneCards custom track

Promoters for SUPT6H Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUPT6H on UCSC Golden Path with GeneCards custom track

Genomic Location for SUPT6H Gene

Chromosome:
17
Start:
28,662,091 bp from pter
End:
28,702,684 bp from pter
Size:
40,594 bases
Orientation:
Plus strand

Genomic View for SUPT6H Gene

Genes around SUPT6H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUPT6H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUPT6H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPT6H Gene

Proteins for SUPT6H Gene

  • Protein details for SUPT6H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7KZ85-SPT6H_HUMAN
    Recommended name:
    Transcription elongation factor SPT6
    Protein Accession:
    Q7KZ85
    Secondary Accessions:
    • A7E2B4
    • Q15737
    • Q6GMQ4
    • Q7KYW9
    • Q7LDK4
    • Q8N526
    • Q92775
    • Q96AH3
    • Q9BTH9
    • Q9BTI2

    Protein attributes for SUPT6H Gene

    Size:
    1726 amino acids
    Molecular mass:
    199073 Da
    Quaternary structure:
    • Interacts with RNA polymerase II and the DRB sensitivity-inducing factor complex (DSIF complex), which is composed of SUPT5H and SUPT4H1. Interacts with human cytomegalovirus/HHV-5 protein UL69. Interacts with KDM6A (By similarity). Interacts (via SH2 domain) with SETD1A (By similarity). Interacts (via SH2 domain) with POLR2A phosphorylated at Ser-2. Interacts with IWS1, AICDA and PAAF1. Interacts with histone H2B and H3.
    SequenceCaution:
    • Sequence=AAB18949.1; Type=Frameshift; Positions=988; Evidence={ECO:0000305}; Sequence=AAC50821.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH33074.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA11479.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SUPT6H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUPT6H Gene

Proteomics data for SUPT6H Gene at MOPED

Post-translational modifications for SUPT6H Gene

  • Ubiquitination at Lys 402, Lys 538, Lys 844, Lys 1002, Lys 1100, Lys 1243, Lys 1341, Lys 1471, and Lys 1512
  • Modification sites at PhosphoSitePlus

Other Protein References for SUPT6H Gene

No data available for DME Specific Peptides for SUPT6H Gene

Domains & Families for SUPT6H Gene

Gene Families for SUPT6H Gene

Suggested Antigen Peptide Sequences for SUPT6H Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7KZ85

UniProtKB/Swiss-Prot:

SPT6H_HUMAN :
  • Contains 1 S1 motif domain.
  • Belongs to the SPT6 family.
Domain:
  • Contains 1 S1 motif domain.
  • Contains 1 SH2 domain.
Family:
  • Belongs to the SPT6 family.
genes like me logo Genes that share domains with SUPT6H: view

Function for SUPT6H Gene

Molecular function for SUPT6H Gene

GENATLAS Biochemistry:
putative chromatin structure regulator,yeast spt6 (suppressor of Ty) homolog,ubiquitously expressed,tighly linked to WHN
UniProtKB/Swiss-Prot Function:
Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.

Gene Ontology (GO) - Molecular Function for SUPT6H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10933715
genes like me logo Genes that share ontologies with SUPT6H: view
genes like me logo Genes that share phenotypes with SUPT6H: view

Animal Model Products

CRISPR Products

miRNA for SUPT6H Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUPT6H Gene

Localization for SUPT6H Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUPT6H Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUPT6H Gene COMPARTMENTS Subcellular localization image for SUPT6H gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for SUPT6H Gene

Pathways & Interactions for SUPT6H Gene

SuperPathways for SUPT6H Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUPT6H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process IEA --
GO:0006338 chromatin remodeling NAS 8786132
GO:0006355 regulation of transcription, DNA-templated NAS 8786132
GO:0006397 mRNA processing IEA --
GO:0010793 regulation of mRNA export from nucleus ISS --
genes like me logo Genes that share ontologies with SUPT6H: view

No data available for Pathways by source and SIGNOR curated interactions for SUPT6H Gene

Drugs & Compounds for SUPT6H Gene

No Compound Related Data Available

Transcripts for SUPT6H Gene

Unigene Clusters for SUPT6H Gene

Suppressor of Ty 6 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUPT6H Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: - -
SP2: - - - - - - - - - - - - -
SP3:
SP4:
SP5:
SP6:

ExUns: 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34a · 34b ^ 35
SP1: - -
SP2: - - - - - - - - - - - - - - - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for SUPT6H Gene

GeneLoc Exon Structure for
SUPT6H
ECgene alternative splicing isoforms for
SUPT6H

Expression for SUPT6H Gene

mRNA expression in normal human tissues for SUPT6H Gene

Protein differential expression in normal tissues from HIPED for SUPT6H Gene

This gene is overexpressed in Lymph node (14.9) and Peripheral blood mononuclear cells (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUPT6H Gene



SOURCE GeneReport for Unigene cluster for SUPT6H Gene Hs.250429

mRNA Expression by UniProt/SwissProt for SUPT6H Gene

Q7KZ85-SPT6H_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SUPT6H: view

Protein tissue co-expression partners for SUPT6H Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SUPT6H Gene

Orthologs for SUPT6H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUPT6H Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUPT6H 35
  • 92.68 (n)
  • 98.96 (a)
SUPT6H 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUPT6H 35
  • 93.45 (n)
  • 99.65 (a)
SUPT6H 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Supt6 35
  • 90.56 (n)
  • 98.09 (a)
Supt6 16
Supt6 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUPT6H 35
  • 99.46 (n)
  • 99.59 (a)
SUPT6H 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Supt6h 35
  • 90.71 (n)
  • 98.38 (a)
oppossum
(Monodelphis domestica)
Mammalia SUPT6H 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
chicken
(Gallus gallus)
Aves SUPT6H 35
  • 80.91 (n)
  • 93.62 (a)
SUPT6H 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17068 35
supt6h 35
  • 77.71 (n)
  • 88.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14650 35
zebrafish
(Danio rerio)
Actinopterygii supt6h 35
  • 74.29 (n)
  • 81.78 (a)
supt6h 36
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12235 35
fruit fly
(Drosophila melanogaster)
Insecta Spt6 37
  • 51 (a)
Spt6 35
  • 56.18 (n)
  • 50.76 (a)
Spt6 36
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003619 35
  • 59.37 (n)
  • 55.52 (a)
worm
(Caenorhabditis elegans)
Secernentea emb-5 35
  • 49.08 (n)
  • 40.38 (a)
emb-5 36
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR031W 35
  • 44.63 (n)
  • 30.58 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11385g 35
  • 44.1 (n)
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPT6 35
  • 42.34 (n)
  • 28.47 (a)
SPT6 36
  • 25 (a)
OneToOne
SPT6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons GTB1 35
  • 44.58 (n)
  • 33.59 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04611 35
  • 46.02 (n)
  • 31.93 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spt6 35
  • 43.53 (n)
  • 33.09 (a)
Species with no ortholog for SUPT6H:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUPT6H Gene

ENSEMBL:
Gene Tree for SUPT6H (if available)
TreeFam:
Gene Tree for SUPT6H (if available)

Paralogs for SUPT6H Gene

No data available for Paralogs for SUPT6H Gene

Variants for SUPT6H Gene

Sequence variations from dbSNP and Humsavar for SUPT6H Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs948169 -- 28,669,546(-) GATTA(C/T)AGGAG intron-variant, upstream-variant-2KB
rs3076012 -- 28,685,508(+) ttatt(-/ATT)gaaac intron-variant
rs4283269 -- 28,670,842(+) ATCAC(A/G)CCATT intron-variant, upstream-variant-2KB
rs7207976 -- 28,677,685(+) AAGTC(A/C/G/T)GTCTC intron-variant
rs7224571 -- 28,695,867(+) CATAG(A/T)GGGTC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SUPT6H Gene

Variant ID Type Subtype PubMed ID
dgv542e199 CNV Deletion 23128226

Variation tolerance for SUPT6H Gene

Residual Variation Intolerance Score: 1.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SUPT6H Gene

Disorders for SUPT6H Gene

MalaCards: The human disease database

(1) MalaCards diseases for SUPT6H Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 17q11.2 deletion syndrome, 1.4mb
  • 17q11 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SUPT6H

Human Genome Epidemiology (HuGE) Navigator
SUPT6H
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUPT6H
genes like me logo Genes that share disorders with SUPT6H: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUPT6H Gene

Publications for SUPT6H Gene

  1. Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h. (PMID: 8786132) Chiang P.-W. … Kurnit D.M. (Genomics 1996) 2 3 4 23 67
  2. The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis. (PMID: 23503590) Wang A.H. … Sartorelli V. (EMBO J. 2013) 2 3
  3. Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. (PMID: 15060154) Endoh M. … Handa H. (Mol. Cell. Biol. 2004) 3 23
  4. Functional interaction between pleiotropic transactivator pUL69 of human cytomegalovirus and the human homolog of yeast chromatin regulatory protein SPT6. (PMID: 10933715) Winkler M. … Stamminger T. (J. Virol. 2000) 3 23
  5. Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6. (PMID: 9480761) Chiang P.W. … Kurnit D.M. (Genomics 1998) 3 23

Products for SUPT6H Gene

Sources for SUPT6H Gene

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