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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUPT6H Gene

protein-coding   GIFtS: 59
GCID: GC17P026989

Suppressor Of Ty 6 Homolog (S. Cerevisiae)

(Previous name: suppressor of Ty (S.cerevisiae) 6 homolog)
Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppressor Of Ty 6 Homolog (S. Cerevisiae)1 2     Suppressor Of Ty (S.Cerevisiae) 6 Homolog1
Tat-Cotransactivator 2 Protein2 3     SPT62
Tat-CT2 Protein2 3     emb-52
SPT6H2 3     Transcription Elongation Factor SPT62
hSPT62 3     KIAA01623

External Ids:    HGNC: 114701   Entrez Gene: 68302   Ensembl: ENSG000001091117   OMIM: 6013335   UniProtKB: Q7KZ853   

Export aliases for SUPT6H gene to outside databases

Previous GC identifers: GC17P026846 GC17P028889 GC17P027134 GC17P027145 GC17P024013 GC17P023197


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SUPT6H Gene: 
SUPT6H (suppressor of Ty 6 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with SUPT6H include pneumonia. GO annotations related to this gene include hydrolase activity, acting on ester bonds and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: SPT6H_HUMAN, Q7KZ85
Function: Acts to stimulate transcriptional elongation by RNA polymerase II

Gene Wiki entry for SUPT6H Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUPT6H gene promoter:
         AhR   Elk-1   Pax-6   Tal-1beta   Meis-1b   Evi-1   E47   Nkx6-1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUPT6H promoter sequence
   Search SABiosciences Chromatin IP Primers for SUPT6H

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUPT6H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

SUPT6H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUPT6H gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P026989:  view genomic region     (about GC identifiers)

Start:
26,989,109 bp from pter      End:
27,029,697 bp from pter
Size:
40,589 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPT6H_HUMAN, Q7KZ85 (See protein sequence)
Recommended Name: Transcription elongation factor SPT6  
Size: 1726 amino acids; 199073 Da
Subunit: Interacts with RNA polymerase II and the DRB sensitivity-inducing factor complex (DSIF complex), which is
composed of SUPT5H and SUPT4H1. Interacts with human cytomegalovirus/HHV-5 protein UL69
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAB18949.1; Type=Frameshift; Positions=988; Sequence=AAC50821.1; Type=Erroneous
initiation; Sequence=AAH33074.1; Type=Erroneous initiation; Sequence=BAA11479.2; Type=Erroneous initiation;
Secondary accessions: A7E2B4 Q15737 Q6GMQ4 Q7KYW9 Q7LDK4 Q8N526 Q92775 Q96AH3 Q9BTH9 Q9BTI2
Alternative splicing: 3 isoforms:  Q7KZ85-1   Q7KZ85-2   Q7KZ85-3   

Explore the universe of human proteins at neXtProt for SUPT6H: NX_Q7KZ85

Explore proteomics data for SUPT6H at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7KZ85

  • SUPT6H Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SUPT6H Protein Expression
    REFSEQ proteins: NP_003161.2  
    ENSEMBL proteins: 
     ENSP00000319104   ENSP00000338143   ENSP00000464545   ENSP00000465508  

    Human Recombinant Protein Products for SUPT6H: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUPT6H 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8786132

    SUPT6H for ontologies           About GeneDecksing



    SUPT6H Antibody Products: 
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    Cloud-Clone Corp. CLIAs for SUPT6H


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    5/8 InterPro protein domains (see all 8):
     IPR012340 NA-bd_OB-fold
     IPR003029 Rbsml_prot_S1_RNA-bd_dom
     IPR023323 Tex-like_dom
     IPR006641 YqgF/RNaseH-like_dom
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q7KZ85

    ProtoNet protein and cluster: Q7KZ85

    1 Blocks protein domain: IPB003029 RNA binding S1

    UniProtKB/Swiss-Prot: SPT6H_HUMAN, Q7KZ85
    Similarity: Belongs to the SPT6 family
    Similarity: Contains 1 S1 motif domain
    Similarity: Contains 1 SH2 domain


    SUPT6H for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPT6H_HUMAN, Q7KZ85
    Function: Acts to stimulate transcriptional elongation by RNA polymerase II

         Genatlas biochemistry entry for SUPT6H:
    putative chromatin structure regulator,yeast spt6 (suppressor of Ty) homolog,ubiquitously expressed,tighly linked
    to WHN

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8786132
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI10933715
    GO:0016788hydrolase activity, acting on ester bonds IEA--
         
    SUPT6H for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SUPT6H:
     Decreased G3BP1 protein expres  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability 
     Elongated cells with protrusio 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SUPT6H 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUPT6H

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUPT6H 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUPT6H 

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SUPT6H (see all 12):
    hsa-miR-200a hsa-miR-877* hsa-miR-141 hsa-miR-135b hsa-miR-1208 hsa-miR-3121-3p hsa-miR-324-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidSUPT6H 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT6H


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SUPT6H

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/95 Interacting proteins for SUPT6H (Q7KZ852, 3 ENSP000003191044) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process ----
    GO:0006338chromatin remodeling NAS8786132
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS8786132
    GO:0006357regulation of transcription from RNA polymerase II promoter ----

    SUPT6H for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUPT6H (SPT6H)

    Search CenterWatch for drugs/clinical trials and news about SUPT6H / SPT6H

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUPT6H gene: 
    NM_003170.3  

    Unigene Cluster for SUPT6H:

    Suppressor of Ty 6 homolog (S. cerevisiae)
    Hs.250429  [show with all ESTs]
    Unigene Representative Sequence: BC150268
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314616(uc002hby.3 uc010crt.3) ENST00000347486 ENST00000577713
    ENST00000584312 ENST00000584285 ENST00000577939 ENST00000581908 ENST00000585230
    ENST00000583972(uc002hbz.1) ENST00000580471 ENST00000581510 ENST00000583340

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUPT6H
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SUPT6H (see all 12):
    hsa-miR-200a hsa-miR-877* hsa-miR-141 hsa-miR-135b hsa-miR-1208 hsa-miR-3121-3p hsa-miR-324-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidSUPT6H 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUPT6H
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUPT6H
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUPT6H

    Additional mRNA sequence: 

    AF070532.1 AK126585.1 AL833607.1 BC003692.1 BC003696.1 BC017105.1 BC033074.1 BC073963.1 
    BC136522.1 BC136524.1 BC150268.1 D79984.1 U38623.1 U38658.1 

    22 DOTS entries:

    DT.445520  DT.95319165  DT.99995474  DT.92330717  DT.100792515  DT.91761930  DT.91919349  DT.120921747 
    DT.86855505  DT.91964469  DT.92376278  DT.95229083  DT.95314216  DT.100792514  DT.120921688  DT.120921727 
    DT.91761922  DT.95229085  DT.99981545  DT.102840448  DT.86847634  DT.91870169 

    24/287 AceView cDNA sequences (see all 287):

    F08860 BP365322 AI693188 BF873909 CB160981 BE796345 BM792062 BQ941693 
    AK126585 BQ676248 AI089571 AL135573 BI255281 CD364746 U38623 BF795108 
    AU147008 BM696118 CD672204 AA642693 AU125788 AA678075 BC017105 BQ682210 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SUPT6H (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
    SP1:                                                        -                 -                                                                                 
    SP2:                                                        -                 -                 -     -     -     -     -     -     -     -     -     -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34a · 34b ^ 35
    SP1:  -     -                                                                                                   
    SP2:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -               
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SUPT6H

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUPT6H expression in normal human tissues (normalized intensities)      SUPT6H embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCTCCCCT
    SUPT6H Expression
    About this image


    SUPT6H expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             oocyte   
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Skeletal Muscle (Muscoskeletal System)
             gastrocnemius muscle   

    See SUPT6H Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUPT6H

    SOURCE GeneReport for Unigene cluster: Hs.250429

    UniProtKB/Swiss-Prot: SPT6H_HUMAN, Q7KZ85
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for SUPT6H
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUPT6H
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT6H

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUPT6H gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Supt65
    Supt6h1
    suppressor of Ty 6 homolog (S. cerevisiae)1, 5 90.56(n)1
    98.09(a)1
      11 (46.74 cM)5
    209261  NM_009297.21  NP_033323.21 
     782067465 
    chicken
    (Gallus gallus)
    Aves SUPT6H1 suppressor of Ty 6 homolog (S. cerevisiae) 81.44(n)
    94.6(a)
      425418  XM_423183.3  XP_423183.3 
    lizard
    (Anolis carolinensis)
    Reptilia SUPT6H6
    SUPT6H6
    Uncharacterized protein
    89(a)
    67(a)
    1 ↔ 1
    possible ortholog
    AAWZ02039681(126-8086)
    GL344005.1(1833-45675)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146502 Xenopus laevis transcribed sequence with strong similarity more 79.12(n)    BJ098459.1 
    zebrafish
    (Danio rerio)
    Actinopterygii supt6h2 suppressor of Ty 6 homolog (S. cerevisiae) 77.98(n)   337866  BC063248.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spt61 , 3 chromatin binding3
    CG12225-PA1
    51(a)3
    56.4(n)1
    51.29(a)1
      5E43
    440001  NM_143705.21  NP_651962.21 
    worm
    (Caenorhabditis elegans)
    Secernentea emb-51 Protein EMB-5 49.18(n)
    39.61(a)
      175621  NM_065568.2  NP_497969.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPT6(YGR116W)4
    SPT61
    Transcription elongation factor required for the maintenance more4
    Spt6p1
    43.34(n)1
    29.12(a)1
      7(720409-724764)4
    8530111, 4  NP_011631.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GTB11 transcription elongation factor SPT6 45.81(n)
    33.48(a)
      842855  NM_105218.4  NP_176723.3 


    ENSEMBL Gene Tree for SUPT6H (if available)
    TreeFam Gene Tree for SUPT6H (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/760 SNPs in SUPT6H are shown (see all 760)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882706141,2
    C--26991392(+) GTGGCA/GACACG 1 -- int10--------
    rs602961411,2
    C,F--26991476(+) AGAGAC/TCATGC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1928461101,2
    --26991630(+) TGAAAG/TTTGGC 1 -- int10--------
    rs743360221,2
    F--26991673(+) CTCCTC/GTATGT 1 -- int11Minor allele frequency- G:0.02NA 120
    rs1853386851,2
    --26991791(+) CAAACC/TTTATC 1 -- int10--------
    rs1407420971,2
    --26991797(+) TTATCA/CTCCCG 1 -- int10--------
    rs561470191,2
    C--26991821(+) TGCTCC/TTATCC 1 -- int10--------
    rs1163469101,2
    C--26991868(+) TTGTTC/GTTCTC 1 -- int10--------
    rs1429163511,2
    --26992139(+) TTTCCA/GTGGCC 1 -- int10--------
    rs99164651,2
    C,F,H--26992367(+) TCGCTC/TTTAGA 1 -- int126Minor allele frequency- T:0.26NS EA NA WA CSA 2354

    HapMap Linkage Disequilibrium report for SUPT6H (26989109 - 27029697 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SUPT6H:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv542e199CNV Deletion23128226

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SUPT6H
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601333    OMIM disorders: --

    2 diseases for SUPT6H:    About MalaCards
    pneumonia    


    SUPT6H for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: SUPT6H (1 document)

    Export disorders for SUPT6H gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUPT6H gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with SUPT6H)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h. (PubMed id 8786132)1, 2, 3, 9 Chiang P.-W.... Kurnit D.M. (1996)
    2. Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. (PubMed id 15060154)1, 2, 9 Endoh M.... Handa H. (2004)
    3. The cellular protein SPT6 is required for efficient replication of human cytomegalovirus. (PubMed id 22171252)1, 2 Cygnar D.... Bresnahan W.A. (2012)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation. (PubMed id 9514752)1, 2 Wu-Baer F.... Gaynor R.B. (1998)
    7. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2 Nagase T.... Nomura N. (1996)
    8. Functional interaction between pleiotropic transactivator pUL69 of human cytomegalovirus and the human homolog of yeast chromatin regulatory protein SPT6. (PubMed id 10933715)1, 9 Winkler M....Stamminger T. (2000)
    9. Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6. (PubMed id 9480761)1, 9 Chiang P.W....Kurnit D.M. (1998)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6830 HGNC: 11470 AceView: SUPT6H Ensembl:ENSG00000109111 euGenes: HUgn6830
    ECgene: SUPT6H H-InvDB: SUPT6H

    (According to HUGE)
    About This Section
    HUGE: KIAA0162

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUPT6H Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SUPT6H Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUPT6H gene:
    Search GeneIP for patents involving SUPT6H

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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