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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SUPT6H Gene

protein-coding GIFtS: 56
GCID: GC17P026989

suppressor of Ty 6 homolog (S. cerevisiae)

(Previous name: suppressor of Ty (S.cerevisiae) 6 homolog )

Search for SUPT6H
in

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Suppressor Of Ty 6 Homolog (S. Cerevisiae)¹ ²		HSPT6¹
SPT6H¹ ² ³		Suppressor Of Ty (S.Cerevisiae) 6 Homolog¹
KIAA0162¹ ³		SPT6²
Tat-Cotransactivator 2 Protein² ³		Emb-5¹
Tat-CT2 Protein² ³		Transcription Elongation Factor SPT6²

External Ids:	HGNC: 11470¹	Entrez Gene: 6830²	Ensembl: ENSG00000109111⁷	OMIM: 601333⁵	UniProtKB: Q7KZ85³

Export aliases for SUPT6H gene to outside databases

Previous GC identifers: GC17P026846 GC17P028889 GC17P027134 GC17P027145 GC17P024013 GC17P023197

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SPT6H_HUMAN, Q7KZ85

Function: Acts to stimulate transcriptional elongation by RNA polymerase II

Gene Wiki entry for SUPT6H

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SUPT6H gene promoter:
AhR Elk-1 Pax-6 Tal-1beta Meis-1b Evi-1 E47 Nkx6-1 Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SUPT6H promoter sequence

Search SABiosciences Chromatin IP Primers for SUPT6H

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUPT6H

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2

SUPT6H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUPT6H gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P026989: view genomic region (about GC identifiers)

Start:	26,989,109 bp from pter	End:	27,029,697 bp from pter
Size:	40,589 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPT6H_HUMAN, Q7KZ85 (See protein sequence)

Recommended Name: Transcription elongation factor SPT6

Size: 1726 amino acids; 199073 Da

Subunit: Interacts with RNA polymerase II and the DRB sensitivity-inducing factor complex (DSIF complex), which is

composed of SUPT5H and SUPT4H1. Interacts with human cytomegalovirus/HHV-5 protein UL69

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=AAB18949.1; Type=Frameshift; Positions=988; Sequence=AAC50821.1; Type=Erroneous initiation;

Sequence=AAH33074.1; Type=Erroneous initiation; Sequence=BAA11479.2; Type=Erroneous initiation;

Secondary accessions: A7E2B4 Q15737 Q6GMQ4 Q7KYW9 Q7LDK4 Q8N526 Q92775 Q96AH3 Q9BTH9 Q9BTI2

Alternative splicing: 3 isoforms: Q7KZ85-1 Q7KZ85-2 Q7KZ85-3

Explore the universe of human proteins at neXtProt for SUPT6H: NX_Q7KZ85

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7KZ85

SUPT6H Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003161.2

ENSEMBL proteins:

ENSP00000319104 ENSP00000338143 ENSP00000464545 ENSP00000465508

Human Recombinant Protein Products for SUPT6H:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SUPT6H

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	8786132

SUPT6H for ontologies About GeneDecksing

SUPT6H Antibody Products:

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	Uscn ELISAs and CLIAs for SUPT6H

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SUPT6H for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR012340 NA-bd_OB-fold

IPR003029 Rbsml_prot_S1_RNA-bd_dom

IPR023323 Tex-like_dom

IPR006641 YqgF/RNaseH-like_dom

IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry Q7KZ85

ProtoNet protein and cluster: Q7KZ85

1 Blocks protein family: IPB003029 RNA binding S1

UniProtKB/Swiss-Prot: SPT6H_HUMAN, Q7KZ85

Similarity: Belongs to the SPT6 family

Similarity: Contains 1 S1 motif domain

Similarity: Contains 1 SH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SPT6H_HUMAN, Q7KZ85

Function: Acts to stimulate transcriptional elongation by RNA polymerase II

Genatlas biochemistry entry for SUPT6H:

putative chromatin structure regulator,yeast spt6 (suppressor of Ty) homolog,ubiquitously expressed,tighly linked to

WHN

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	8786132
GO:0003723	RNA binding	IEA	--
GO:0016788	hydrolase activity, acting on ester bonds	IEA	--

SUPT6H for ontologies About GeneDecksing

Phenotypes:
5 GenomeRNAi human phenotypes for SUPT6H:

Decreased G3BP1 protein expres	Decreased influenza A H1N1 (A/	Decreased influenza A/WSN/33 r	Decreased viability
Elongated cells with protrusio

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SUPT6H

miRNA Products:		OriGene 3'-UTR Clone: SUPT6H Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUPT6H
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SUPT6H (see all 12):
		hsa-miR-200a hsa-miR-877* hsa-miR-141 hsa-miR-135b hsa-miR-1208 hsa-miR-3121-3p hsa-miR-324-5p hsa-miR-4257

		SwitchGear 3'UTR luciferase reporter plasmid: SUPT6H 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against SUPT6H

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SUPT6H
			Sirion Biotech Customized adenovirus for overexpression of SUPT6H Sirion Biotech Customized adenovirus for potent knockdown of SUPT6H

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUPT6H (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUPT6H OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SUPT6H (NM_003170)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUPT6H
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SUPT6H
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		Sirion Biotech Customized stable knockdown cell line services for SUPT6H Sirion Biotech Customized inducible knockdown cell line services for SUPT6H

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT6H

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SUPT6H

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/88 Interacting proteins for SUPT6H (Q7KZ85^{2, 3} ENSP00000319104⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 88)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=4
HIST1H4B	P62805³	I2D: score=4
HIST1H4C	P62805³	I2D: score=4
HIST1H4D	P62805³	I2D: score=4
HIST1H4E	P62805³	I2D: score=4

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006338	chromatin remodeling	NAS	8786132
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	NAS	8786132
GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0019048	virus-host interaction	IEA	--

SUPT6H for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SUPT6H
Search CenterWatch for drugs/clinical trials and news about SUPT6H / SPT6H

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SUPT6H gene:

NM_003170.3

Unigene Cluster for SUPT6H:

Suppressor of Ty 6 homolog (S. cerevisiae)

Hs.250429 [show with all ESTs]

Unigene Representative Sequence: BC150268

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000314616(uc002hby.3 uc010crt.3) ENST00000347486 ENST00000577713

ENST00000584312 ENST00000584285 ENST00000577939 ENST00000581908 ENST00000585230

ENST00000583972(uc002hbz.1) ENST00000580471 ENST00000581510 ENST00000583340

miRNA Products:		OriGene 3'-UTR Clone: SUPT6H Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUPT6H
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SUPT6H (see all 12):
		hsa-miR-200a hsa-miR-877* hsa-miR-141 hsa-miR-135b hsa-miR-1208 hsa-miR-3121-3p hsa-miR-324-5p hsa-miR-4257

		SwitchGear 3'UTR luciferase reporter plasmid: SUPT6H 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		Browse OriGene 29mer shRNA kits OriGene siRNA: SUPT6H
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		Sirion Biotech Custom design and validation of potent shRNA sequences against SUPT6H

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUPT6H (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUPT6H OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SUPT6H (NM_003170)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUPT6H
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUPT6H

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUPT6H Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUPT6H
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUPT6H

Additional cDNA sequence:

AF070532.1 AK126585.1 AL833607.1 BC003692.1 BC003696.1 BC017105.1 BC033074.1 BC073963.1

BC136522.1 BC136524.1 BC150268.1 D79984.1 U38623.1 U38658.1

22 DOTS entries:

DT.445520 DT.95319165 DT.99995474 DT.92330717 DT.100792515 DT.91761930 DT.91919349 DT.120921747

DT.86855505 DT.91964469 DT.92376278 DT.95229083 DT.95314216 DT.100792514 DT.120921688 DT.120921727

DT.91761922 DT.95229085 DT.99981545 DT.102840448 DT.86847634 DT.91870169

24/287 AceView cDNA sequences (see all 287):

BU857632 BE792533 BF795108 AW338170 U38623 BG748927 BM792062 CD364746

AW088653 BQ682210 BM727811 BM453236 BI087722 AF070532 CB123617 AA312222

BM681452 AU121122 BM727344 BQ676248 AI434110 AI089571 BU174003 AK126585

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SUPT6H (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22a	·
SP1:																			-						-
SP2:																			-						-						-		-		-		-		-		-		-		-		-		-		-
SP3:
SP4:
SP5:

ExUns:	22b	^	23a	·	23b	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31a	·	31b	^	32	^	33a	·	33b	^	34a	·	34b	^	35
SP1:	-		-
SP2:	-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SUPT6H

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SUPT6H expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTCTCCCCT

About this image

SUPT6H expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Early Gonad

Testis Somatic Cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SUPT6H Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SUPT6H

SOURCE GeneReport for Unigene cluster: Hs.250429

UniProtKB/Swiss-Prot: SPT6H_HUMAN, Q7KZ85

Tissue specificity: Ubiquitously expressed

SABiosciences Custom PCR Arrays for SUPT6H

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUPT6H

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT6H

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SUPT6H gene from 11/36 species (see all 36) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Supt6⁵ Supt6h¹	suppressor of Ty 6 homolog (S. cerevisiae)^{1, 5}	90.56(n)¹ 98.09(a)¹		11 (46.74 cM)⁵ 20926¹ NM_009297.2¹ NP_033323.2¹ 78206746⁵
chicken (Gallus gallus)	Aves	SUPT6H¹	suppressor of Ty 6 homolog (S. cerevisiae)	81.44(n) 94.6(a)		425418 XM_423183.3 XP_423183.3
lizard (Anolis carolinensis)	Reptilia	-- SUPT6H⁶	--	7(a) 65(a)	possible ortholog 1 ↔ 1	AAWZ02039681(126-7854) GL344005.1(1833-45578)
African clawed frog (Xenopus laevis)	Amphibia	Xl.14650²	Xenopus laevis transcribed sequence with strong similarity more	79.12(n)		BJ098459.1
zebrafish (Danio rerio)	Actinopterygii	supt6h²	suppressor of Ty 6 homolog (S. cerevisiae)	77.98(n)		337866 BC063248.1
fruit fly (Drosophila melanogaster)	Insecta	Spt6^{1 , 3}	chromatin binding³ CG12225-PA¹	51(a)³ 56.4(n)¹ 51.29(a)¹		5E4³ 44000¹ NM_143705.2¹ NP_651962.2¹
worm (Caenorhabditis elegans)	Secernentea	emb-5¹	Protein EMB-5	49.18(n) 39.61(a)		175621 NM_065568.2 NP_497969.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SPT6(YGR116W)⁴ SPT6¹	Transcription elongation factor required for the maintenance more⁴ Spt6p¹	43.34(n)¹ 29.12(a)¹		7(720409-724764)⁴ 853011^{1, 4} NP_011631.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	GTB1¹	transcription elongation factor SPT6	45.81(n) 33.48(a)		842855 NM_105218.4 NP_176723.3
rice (Oryza sativa)	Liliopsida	--	SH2 motif, putative, expressed	23(a)	1 ↔ 1	5(24238766-24248545)

ENSEMBL Gene Tree for SUPT6H (if available)
TreeFam Gene Tree for SUPT6H (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188270614^1,2		--	26991392(+)	`GTGGCA/GACACG`	1	--	int¹		0	--	--	--	--
rs60296141^1,2	C	--	26991476(+)	`AGAGAC/TCATGC`	1	--	int¹		1		WA	2
rs192846110^1,2		--	26991630(+)	`TGAAAG/TTTGGC`	1	--	int¹		0	--	--	--	--
rs74336022^1,2	F	--	26991673(+)	`CTCCTC/GTATGT`	1	--	int¹		1		NA	120
rs185338685^1,2		--	26991791(+)	`CAAACC/TTTATC`	1	--	int¹		0	--	--	--	--
rs140742097^1,2		--	26991797(+)	`TTATCA/CTCCCG`	1	--	int¹		0	--	--	--	--
rs56147019^1,2		--	26991821(+)	`TGCTCC/TTATCC`	1	--	int¹		0	--	--	--	--
rs116346910^1,2	C	--	26991868(+)	`TTGTTC/GTTCTC`	1	--	int¹		0	--	--	--	--
rs142916351^1,2		--	26992139(+)	`TTTCCA/GTGGCC`	1	--	int¹		0	--	--	--	--
rs9916465^1,2	C,F,H	--	26992367(+)	`TCGCTC/TTTAGA`	1	--	int¹		26		NS EA NA WA CSA	2354

HapMap Linkage Disequilibrium report for SUPT6H (26989109 - 27029697 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SUPT6H: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SUPT6H for disorders About MalaCards

SUPT6H for disorders About GeneDecksing

OMIM gene information: 601333 OMIM disorders: --

Human Genome Epidemiology (HuGE) Navigator: SUPT6H (1 document)

Export disorders for SUPT6H gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SUPT6H gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with SUPT6H)

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Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h. (PubMed id 8786132)^{1, 2, 3, 9} Chiang P.-W.... Kurnit D.M. (1996)
Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. (PubMed id 15060154)^{1, 2, 9} Endoh M.... Handa H. (2004)
The cellular protein SPT6 is required for efficient replication of human cytomegalovirus. (PubMed id 22171252)^{1, 2} Cygnar D.... Bresnahan W.A. (2012)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation. (PubMed id 9514752)^{1, 2} Wu-Baer F.... Gaynor R.B. (1998)
Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)^{1, 2} Nagase T.... Nomura N. (1996)
Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6. (PubMed id 9480761)^{1, 9} Chiang P.W....Kurnit D.M. (1998)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6830	HGNC: 11470	AceView: SUPT6H	Ensembl:ENSG00000109111	euGenes: HUgn6830
ECgene: SUPT6H	H-InvDB: SUPT6H

(According to HUGE)
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HUGE: KIAA0162

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SUPT6H	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SUPT6H	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SUPT6H gene
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Patent Information for SUPT6H gene:
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suppressor of Ty 6 homolog (S. cerevisiae)

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suppressor of Ty 6 homolog (S. cerevisiae)

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