SUPT5H Gene protein-coding GIFtS : 58 GCID: GC19 P039936
Suppressor Of Ty 5 Homolog (S. Cerevisiae) suppressor of Ty (S.cerevisiae) 5 homolog )
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Aliasesfor SUPT5H gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Suppressor Of Ty 5 Homolog (S. Cerevisiae) 1 2 hSPT52 3 SPT52 3 5 Tat-Cotransactivator 1 Protein2 3 SPT5H2 3 Suppressor Of Ty (S.Cerevisiae) 5 Homolog1 DRB Sensitivity-Inducing Factor 160 KDa Subunit2 3 Tat-CT12 DRB Sensitivity-Inducing Factor Large Subunit2 3 Transcription Elongation Factor SPT52 DSIF Large Subunit2 3 Tat-CT1 Protein3 DSIF P1602 3
Export aliases for SUPT5H gene to outside databases Previous GC identifers: GC19P040577 GC19P040327 GC19P044612 GC19P044628 GC19P036382
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Summariesfor SUPT5H gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section GeneCards Summary for SUPT5H Gene: SUPT5H (suppressor of Ty 5 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with SUPT5H include wolf-hirschhorn syndrome kaposi's sarcoma related super-pathways are Processing of Capped Intron-Containing Pre-mRNA and Formation of HIV-1 elongation complex containing HIV-1 Tat . GO annotations related to this gene include enzyme binding and protein heterodimerization activity . UniProtKB/Swiss-Prot: SPT5H_HUMAN, O00267 Function : Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processingand transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNAguanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factorcomplex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptionalpausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promotepausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II attranscription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blockedtranscripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allowrepeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptionalelongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nucleartranscriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from theHIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences Gene Wiki entry for SUPT5H Gene
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Genomic Viewsfor SUPT5H gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NT_011109.16 NC_018930.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SUPT5H gene promoter:HSF2 ZIC2/Zic2 Pax-4a YY1 GATA-1 Other transcription factors Search SABiosciences Chromatin IP Primers for SUPT5H Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUPT5H
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q13 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13 SUPT5H Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P039936: view genomic region
(about GC identifiers )
Start: 39,926,796 bp from pter End:
39,967,310 bp from pter
Size: 40,515 bases Orientation:
plus strand
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Proteinsfor SUPT5H gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: SPT5H_HUMAN, O00267 See
protein sequence )Recommended Name: Size : 1087 amino acids; 121000 DaSubunit : Interacts with SUPT4H1 to form DSIF. DSIF interacts with the positive transcription elongation factor bcomplex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNApolymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A byP-TEFb. DSIF also interacts with the NELF complex, which is composed of WHSC2/NELFA, COBRA1/NELFB, TH1L/NELFD andRDBP/NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. DSIF also interactswith PRMT1/HRMT1L2, HTATSF1/TATSF1, RNGTT/CAP1A, PRMT5/SKB1, SUPT6H, and can interact with PIN1. Component of acomplex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNApolymerase II, SUPT5H, and NCL/nucleolin
Subcellular location : NucleusSequence caution : Sequence=BAD92494.1; Type=Erroneous initiation;4 PDB 3D structures from :2DO3 (3D) 2E6Z (3D) 2E70 (3D) 3H7H (3D) Secondary accessions : O43279 Q59G52 Q99639Alternative splicing : 2 isoforms : O00267-1 O00267-2 Explore the universe of human proteins at neXtProt for SUPT5H: NX_O00267 Explore proteomics data for SUPT5H at MOPED Post-translational modifications:
UniProtKB: Methylated by PRMT1/HRMT1L2 and PRMT5/SKB1. Methylation negatively regulates interaction with P-TEFb and RNApolymerase II UniProtKB: Phosphorylated by CDK7 and CDK9. Phosphorylation by P-TEFb alleviates transcriptional pausing and can stimulatetranscriptional elongation from the HIV-1 LTR. P-TEFb dependent phosphorylation is stimulated by the HIV-1 Tatprotein. Phosphorylation may also stimulate interaction with PIN1. Bulk phosphorylation occurs predominantly inmitosis View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_O00267 SUPT5H Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins (4 alternative transcripts): NP_001104490.1 NP_001124296.1 NP_001124297.1 NP_003160.2 ENSEMBL proteins: ENSP00000471561 ENSP00000470252 ENSP00000472675 ENSP00000470595 ENSP00000352117 ENSP00000469090 ENSP00000469915 ENSP00000404029 ENSP00000384505 Reactome Protein details: O00267 Human Recombinant Protein Products for SUPT5H: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing SUPT5H Antibody Products: Assay Products for SUPT5H:
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Protein
Domains /for SUPT5H gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section 5/7 InterPro protein domains (see all 7 ):
Graphical View of Domain Structure for InterPro Entry O00267 ProtoNet protein and cluster: O00267
1 Blocks protein domain : IPB006646 UniProtKB/Swiss-Prot: SPT5H_HUMAN, O00267 Similarity : Belongs to the SPT5 familySimilarity : Contains 5 KOW domainsAbout GeneDecksing
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Functionfor SUPT5H gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: SPT5H_HUMAN, O00267 Function : Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processingand transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNAguanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factorcomplex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptionalpausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promotepausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II attranscription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blockedtranscripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allowrepeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptionalelongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nucleartranscriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from theHIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences
Genatlas biochemistry entry for SUPT5H putative chromatin structure regulator yeast Spt5 homolog,(histones group) Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Phenotypes: 4 GenomeRNAi human phenotypes for SUPT5H :Animal Models: Cell Line GenScript Custom overexpressing Cell Line Services for SUPT5H Search LifeMap BioReagents cell lines for SUPT5H In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT5H
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Pathways & Interactionsfor SUPT5H gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for SUPT5H About (see all 7 ) See pathways by source SuperPath Selected contained pathways About (see all per SuperPath ) 1 mRNA Splicing - Major Pathway 2 Formation of RNA Pol II elongation complex 3 HIV Life Cycle 4 Transcription 5 Generic Transcription Pathway
Pathways by source See SuperPaths Show all pathways 1 1 5/27 (see all 27 )About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SUPT5H 5/203 Interacting proteins for SUPT5H (O00267 1 , 2 , 3 via UniProtKB, MINT, STRING, and/or I2D (see all 203 )About this table Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000122 negative regulation of transcription from RNA polymerase II promoter
IDA 10075709 GO:0006338 chromatin remodeling
NAS 10075709 GO:0006354 DNA-dependent transcription, elongation
IDA 10075709 GO:0006357 regulation of transcription from RNA polymerase II promoter
-- -- GO:0006366 transcription from RNA polymerase II promoter
TAS --
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Drugs & Compoundsfor SUPT5H gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for SUPT5H (SPT5H) 1 Novoseek inferred chemical compound relationship for SUPT5H gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole
87
4
19860741 (1), 9450929 (1), 10075709 (1)
SUPT5H / SPT5H
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Transcriptsfor SUPT5H gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SUPT5H gene (4 alternative transcripts): NM_001111020.2 NM_001130824.1 NM_001130825.1 NM_003169.3 Unigene Cluster for SUPT5H:
Suppressor of Ty 5 homolog (S. cerevisiae) Hs.631604 [show with all ESTs ] Unigene Representative Sequence: NM_003169 18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19 ): ENST00000594990 ENST00000599117 ENST00000601515 ENST00000595368 ENST00000594729 ENST00000601978 ENST00000359191 (uc002olr.4 ) ENST00000598725 ENST00000598459 ENST00000593727 ENST00000598786 ENST00000599907 ENST00000598520 ENST00000599335 ENST00000598117 ENST00000596208 ENST00000600818 ENST00000432763 (uc002olo.4 uc002olp.4 uc002oln.4 )Congresses - knowledge worth sharing: European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014 Primer SUPT5H human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AB000516.1 AB209257.1 AF040253.1 AF052165.1 AK091476.1 AK295137.1 AK296117.1 AK302954.1 AK303480.1 BC024203.2 BC113039.1 U56402.1 Y12790.1
24/32 DOTS entries (see all 32 ): DT.91760765 DT.452135
DT.100048831 DT.100809109 DT.100820836 DT.121440403 DT.100820829 DT.100820832 DT.86993018 DT.121440406 DT.95320049 DT.121440285 DT.121440427 DT.97864300 DT.99993811 DT.100042588 DT.100820835 DT.121440442 DT.95259689 DT.40115069 DT.95211634 DT.100732126 DT.121440425 DT.121440428 24/471 AceView cDNA sequences (see all 471 ):
AL526061 BU171811 BX413900 D20872 CR623112 AU141591 AU121927 AF052165 AA304902 CB129665 AF040253 BU166910 AA743559 BM827529 AW960806 BM013873 BU688238 BQ428302 BU075668 BI223682 CB528841 AA514292 BX100239 AA325168 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SUPT5H (see all 8 ) About this scheme ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ SP1 : - - SP2 : SP3 : - - - - - - - - - - SP4 : - - SP5 :
ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b SP1 : - - SP2 : SP3 : - - - - - - - - SP4 : SP5 :
ECgene alternative splicing isoforms for SUPT5H
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Expression for SUPT5H gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SUPT5H expression in normal human tissues
(normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: TGCTCTGTGTAbout this image
See SUPT5H Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SUPT5H SOURCE GeneReport for Unigene cluster: Hs.631604 UniProtKB/Swiss-Prot: SPT5H_HUMAN, O00267 Tissue specificity : Ubiquitously expressedSABiosciences Custom PCR Arrays for SUPT5H Primer SUPT5H human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT5H
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Orthologsfor SUPT5H gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for SUPT5H gene from 10/23 species (see all 23 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Supt55 1
suppressor of Ty 5 homolog (S. cerevisiae)1, 5
88.99(n) 1 97.96(a) 1
7 (16.68 cM) 5 20924 1 NM_013676.1 1 NP_038704.1 1 28314898 5
chicken Aves SUPT5H1
suppressor of Ty 5 homolog (S. cerevisiae)
84.65(n) 96.19(a)
426493 NM_001031384.1 NP_001026555.1
lizard Reptilia SUPT5H6
Uncharacterized protein
95(a)
1 ↔ 1
GL343635.1(350882-380593)
African clawed frog Amphibia Xl.50442
Xenopus laevis transcribed sequence with moderate similarity to protein refNP_003160.1 (H.sapiens) suppressor of Ty 5 homolog (S. cerevisiae); suppressor of Ty (S.cerevisiae) 5 homolog [Homo sapiens] less
76.12(n)
CA971229.1
zebrafish Actinopterygii supt5h2
suppressor of Ty 5 homolog (S. cerevisiae)
79.52(n)
64275 AF288409.1
fruit fly Insecta Spt51 3
transcription transcription elongation3 1
53(a) 3 58.6(n) 1 56.83(a) 1
53442 1 NM_144353.3 1 NP_652610.1 1
worm Secernentea spt-51
Protein SPT-5
49.25(n) 44.01(a)
178143 NM_069882.4 NP_502283.1
baker's yeast Saccharomycetes SPT5(YML010W)4 1
Protein involved in regulating Pol I and Pol II transcription and pre-mRNA processing; forms a complex with Spt4p; contains a C-terminal repeat domain that is a target for phosphorylation by Sgv1p less 4 1
42.65(n) 1 32.6(a) 1
13(247677-250868) 4 854999 1, 4 NP_013703.1 1, 4
thale cress eudicotyledons GTA21
global transcription factor group A2
46.16(n) 38.37(a)
826391 NM_116904.5 NP_192575.3
rice Liliopsida Os02g07720001
hypothetical protein
47.16(n) 37.76(a)
9267296 NM_001186230.1 NP_001173159.1
ENSEMBL Gene Tree for SUPT5H (if available)TreeFam Gene Tree for SUPT5H (if available)
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Paralogsfor SUPT5H gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section
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Genomic Variantsfor SUPT5H gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 19 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for SUPT5H (39926796 - 39967310 bp)
Structural Variations Database of Genomic Variants (DGV) 3 variations for SUPT5H : About this table SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor SUPT5H gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section OMIM gene information: 602102
OMIM disorders : --4 : About MalaCards wolf-hirschhorn syndrome kaposi's sarcoma sarcoma hepatitis 1 disease from the University of Copenhagen DISEASES database for SUPT5H :Wolf-Hirschhorn syndrome About GeneDecksing 2 Novoseek inferred disease relationships for SUPT5H gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency
29.9
1
16107696 (1)
shock
0
2
11040216 (1), 15380072 (1)
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Publicationsfor SUPT5H gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SUPT5H gene, integrated from 9 sources (see all 107 ):(articles sorted by number of sources associating them with SUPT5H) Utopia : connect your pdf to the dynamic
Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5. (PubMed id 8975720) 1 , 2 , 3, 9(1996) Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties. (PubMed id 12718890) 1 , 2 , 9(2003) Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila. (PubMed id 15380072) 1 , 2 , 9(2004) Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin- dependent kinase-activating kinase. (PubMed id 11145967) 1 , 2 , 9(2001) Tat-SF1 protein associates with RAP30 and human SPT5 proteins. (PubMed id 10454543) 1 , 2 , 9(1999) Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription. (PubMed id 15564463) 1 , 2 , 9(2004) Structure and function of the human transcription elongation factor DSIF. (PubMed id 10075709) 1 , 2 , 9(1999) DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. (PubMed id 9450929) 1 , 2 , 9(1998) Crystal structure of the human transcription elongati on factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface. (PubMed id 19860741) 1 , 2 , 9(2010) Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. (PubMed id 16327805) 1 , 2 , 9(2006)
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Genome Databases showing SUPT5H gene
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and/or
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Specialized Databases showing SUPT5H gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for SUPT5H gene: SUPT5H GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SUPT5H gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SUPT5H QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUPT5H QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for SUPT5H (SPT5)
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT5H
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SUPT5H
LSBio Antibodies in human mouse rat
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