Aliases for SUPT5H Gene
Aliases for SUPT5H Gene
External Ids for SUPT5H Gene
- HGNC: 11469
- Entrez Gene: 6829
- Ensembl: ENSG00000196235
- OMIM: 602102
- UniProtKB: O00267
Previous GeneCards Identifiers for SUPT5H Gene
- GC19P040577
- GC19P040327
- GC19P044612
- GC19P044628
- GC19P039936
- GC19P036382
Summaries for SUPT5H Gene
GeneCards Summary for SUPT5H Gene
SUPT5H (SPT5 Homolog, DSIF Elongation Factor Subunit) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Formation of HIV elongation complex in the absence of HIV Tat. Gene Ontology (GO) annotations related to this gene include chromatin binding.
UniProtKB/Swiss-Prot for SUPT5H Gene
-
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3 terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
Additional gene information for SUPT5H Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT5H Gene
Genomics for SUPT5H Gene
GeneHancer (GH) Regulatory Elements for SUPT5H Gene
Regulatory Element Products
Genomic Locations for SUPT5H Gene
- chr19:39,436,156-39,476,670
- (GRCh38/hg38)
- Size:
- 40,515 bases
- Orientation:
- Plus strand
- chr19:39,926,796-39,967,310
- (GRCh37/hg19)
Genomic View for SUPT5H Gene
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC


RefSeq DNA sequence for SUPT5H Gene
Proteins for SUPT5H Gene
-
Protein details for SUPT5H Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00267-SPT5H_HUMAN
- Recommended name:
- Transcription elongation factor SPT5
- Protein Accession:
- O00267
- O43279
- Q59G52
- Q99639
Protein attributes for SUPT5H Gene
- Size:
- 1087 amino acids
- Molecular mass:
- 121000 Da
- Quaternary structure:
-
- Interacts with SUPT4H1 to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of WHSC2/NELFA, COBRA1/NELFB, TH1L/NELFD and RDBP/NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. DSIF also interacts with PRMT1/HRMT1L2, HTATSF1/TATSF1, RNGTT/CAP1A, PRMT5/SKB1, SUPT6H, and can interact with PIN1. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin.
- SequenceCaution:
-
- Sequence=BAD92494.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for SUPT5H Gene
Protein Expression for SUPT5H Gene
Post-translational modifications for SUPT5H Gene
- Methylated by PRMT1/HRMT1L2 and PRMT5/SKB1. Methylation negatively regulates interaction with P-TEFb and RNA polymerase II.
- Phosphorylated by CDK7 and CDK9. Phosphorylation by P-TEFb alleviates transcriptional pausing and can stimulate transcriptional elongation from the HIV-1 LTR. P-TEFb dependent phosphorylation is stimulated by the HIV-1 Tat protein. Phosphorylation may also stimulate interaction with PIN1. Bulk phosphorylation occurs predominantly in mitosis.
- Ubiquitination at isoforms=2147, isoforms=2199, isoforms=2213, isoforms=2306, posLast=323323, isoforms=2650, and isoforms=2718
Other Protein References for SUPT5H Gene
Antibody Products
- Cell Signaling Technology (CST) Antibodies for SUPT5H (SPT5)
- Novus Biologicals Antibodies for SUPT5H
-
Abcam antibodies for SUPT5H
- Invitrogen Antibodies for SUPT5H
- Search GeneTex for Antibodies for SUPT5H
-
Santa Cruz Biotechnology (SCBT) Antibodies for SUPT5H
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SUPT5H
- Origene Custom Protein Services for SUPT5H
- Novus Biologicals proteins for SUPT5H
- antibodies-online: Search results for 7 available SUPT5H Proteins ranked by validation data
- Compare Top SUPT5H Proteins
-
Quality Products:
- Search GeneTex for Proteins for SUPT5H
Assay Products
- antibodies-online: Search results for 3 available SUPT5H Elisa Kits ranked by validation data
- Compare Top SUPT5H Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SUPT5H Gene
Domains & Families for SUPT5H Gene
Gene Families for SUPT5H Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SUPT5H Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SUPT5H Gene
Graphical View of Domain Structure for InterPro Entry
O00267- Family:
-
- Belongs to the SPT5 family.
Function for SUPT5H Gene
Molecular function for SUPT5H Gene
- GENATLAS Biochemistry:
- putative chromatin structure regulator yeast Spt5 homolog,(histones group)
- UniProtKB/Swiss-Prot Function:
- Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3 terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
Phenotypes From GWAS Catalog for SUPT5H Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IBA | -- |
GO:0003682 | chromatin binding | IEA | -- |
GO:0003723 | RNA binding | HDA,IDA | 22658674 |
GO:0003729 | mRNA binding | IBA | -- |
GO:0005515 | protein binding | IPI | 10075709 |
Phenotypes for SUPT5H Gene
- MGI mutant phenotypes for SUPT5H:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SUPT5H:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Negative genetic interaction between MUS81-/- and MUS81+/+
- shRNA abundance <= 50%
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Increased G1 DNA content
- G0/1 arrest
- Decreased IL-8 secretion
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased homologous recombination repair frequency
- Increased viability with MLN4924 (a NAE inhibitor)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability of wild-type and TP53 knockout cells
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Downregulation of NFkappaB pathway
Animal Models for SUPT5H Gene
- MGI Knock Outs for SUPT5H:
-
- Supt5 tm2a(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SUPT5H
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SUPT5H gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SUPT5H gene
- Search ViGene Biosciences for SUPT5H
CRISPR Products
-
OriGene CRISPR knockouts for SUPT5H
- genomics-online: gRNA clones - Search results for available SUPT5H gene related products
- Applied Biological Materials CRISPR for SUPT5H
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUPT5H
- GenScript: Design CRISPR guide RNA sequences for SUPT5H
miRNA for SUPT5H Gene
- miRTarBase miRNAs that target SUPT5H
-
- hsa-mir-155-5p (MIRT020754)
- hsa-mir-34a-5p (MIRT025307)
- hsa-mir-26b-5p (MIRT029450)
- hsa-mir-1229-3p (MIRT036363)
- hsa-mir-935 (MIRT036670)
- hsa-mir-93-3p (MIRT038889)
- hsa-mir-92b-3p (MIRT040704)
- hsa-mir-484 (MIRT042043)
- hsa-mir-324-3p (MIRT042864)
- hsa-mir-149-5p (MIRT045555)
- hsa-mir-92a-3p (MIRT049464)
- hsa-mir-16-5p (MIRT051148)
miRNA Products
- Search ViGene Biosciences for SUPT5H
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SUPT5H
- Browse OriGene Inhibitory RNA Products For SUPT5H
- genomics-online: shRNA clones - Search results for available SUPT5H gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SUPT5H gene
Clone Products
- Sino Biological Human cDNA Clone for SUPT5H
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SUPT5H
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SUPT5H
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SUPT5H gene related products
- orf clones - Search results for available SUPT5H gene related products
- Applied Biological Materials Clones for SUPT5H
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SUPT5H gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SUPT5H gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SUPT5H gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUPT5H Gene
Localization for SUPT5H Gene
Subcellular locations from UniProtKB/Swiss-Prot for SUPT5H Gene
- Nucleus.
- Nucleoplasm (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 10075709 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0032044 | DSIF complex | IDA | 9450929 |
Pathways & Interactions for SUPT5H Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Formation of HIV elongation complex in the absence of HIV Tat | ||
2 | mRNA Capping |
.93
|
|
3 | HIV Life Cycle |
.92
.65
|
.45
|
4 | Gene Expression |
.48
|
|
5 | Chromatin Regulation / Acetylation |
Pathways by source for SUPT5H Gene
1 Cell Signaling Technology pathway for SUPT5H Gene
2 BioSystems pathways for SUPT5H Gene
Interacting Proteins for SUPT5H Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 9450929 |
GO:0006338 | chromatin remodeling | NAS | 10075709 |
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006354 | DNA-templated transcription, elongation | IDA | 10075709 |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
Transcripts for SUPT5H Gene
mRNA/cDNA for SUPT5H Gene
- (7) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (471) Selected AceView cDNA sequences:
- (20) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SUPT5H Gene
CRISPR Products
-
OriGene CRISPR knockouts for SUPT5H
- genomics-online: gRNA clones - Search results for available SUPT5H gene related products
- Applied Biological Materials CRISPR for SUPT5H
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUPT5H
- GenScript: Design CRISPR guide RNA sequences for SUPT5H
miRNA Products
- Search ViGene Biosciences for SUPT5H
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SUPT5H
- Browse OriGene Inhibitory RNA Products For SUPT5H
- genomics-online: shRNA clones - Search results for available SUPT5H gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SUPT5H gene
Clone Products
- Sino Biological Human cDNA Clone for SUPT5H
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SUPT5H
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SUPT5H
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SUPT5H gene related products
- orf clones - Search results for available SUPT5H gene related products
- Applied Biological Materials Clones for SUPT5H
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP8: |
ExUns: | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30a | · | 30b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||
SP8: |
Expression for SUPT5H Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUPT5H Gene
NURSA nuclear receptor signaling pathways regulating expression of SUPT5H Gene:
SUPT5HSOURCE GeneReport for Unigene cluster for SUPT5H Gene:
Hs.631604mRNA Expression by UniProt/SwissProt for SUPT5H Gene:
O00267-SPT5H_HUMANEvidence on tissue expression from TISSUES for SUPT5H Gene
- Nervous system(5)
- Liver(4.3)
- Muscle(4.3)
- Pancreas(3.5)
- Lung(2.8)
- Blood(2.6)
Primer Products
-
OriGene qPCR primer pairs for SUPT5H
-
OriGene qPCR primer pairs and template standards for SUPT5H
- genomics-online: primer clones - Search results for available SUPT5H gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUPT5H Gene
Orthologs for SUPT5H Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SUPT5H 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | SUPT5H 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | SUPT5H 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | SUPT5H 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | SUPT5H 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Supt5h 33 |
|
||
mouse (Mus musculus) |
Mammalia | Supt5 33 16 34 |
|
||
chicken (Gallus gallus) |
Aves | SUPT5H 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | SUPT5H 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | supt5h 33 |
|
||
Str.2822 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.5044 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | supt5h 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005021 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Spt5 35 33 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | spt-5 33 34 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADR187W 33 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B00891g 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPT5 33 34 36 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | GTA2 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os02g0772000 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
bread mold (Neurospora crassa) |
Ascomycetes | NCU06929 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | spt5 33 |
|
- Species where no ortholog for SUPT5H was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SUPT5H Gene
No data available for Paralogs for SUPT5H Gene
Variants for SUPT5H Gene
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000035407 | -- | 39,444,068(+) | CTC/C | upstream_transcript_variant | |
rs1000094731 | -- | 39,471,970(+) | C/T | intron_variant | |
rs1000139640 | -- | 39,443,744(+) | C/A | upstream_transcript_variant | |
rs1000207127 | -- | 39,449,222(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
rs1000275443 | -- | 39,447,020(+) | C/G | genic_upstream_transcript_variant, intron_variant |
Additional Variant Information for SUPT5H Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUPT5H Gene
Disorders for SUPT5H Gene
Additional Disease Information for SUPT5H
No disorders were found for SUPT5H Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUPT5H Gene
Publications for SUPT5H Gene
- Structure and function of the human transcription elongation factor DSIF. (PMID: 10075709) Yamaguchi Y … Handa H (The Journal of biological chemistry 1999) 2 3 4 22 58
- Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5. (PMID: 8975720) Chiang PW … Kurnit DM (Genomics 1996) 2 3 4 22 58
- Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface. (PMID: 19860741) Wenzel S … Wöhrl BM (The Biochemical journal 2009) 3 4 22 58
- Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. (PMID: 16327805) Larochelle S … Fisher RP (Nature structural & molecular biology 2006) 3 4 22 58
- Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. (PMID: 15060154) Endoh M … Handa H (Molecular and cellular biology 2004) 3 4 22 58
Products for SUPT5H Gene
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- Novus Biologicals Antibodies for SUPT5H
- Novus Biologicals proteins for SUPT5H
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for SUPT5H
- Find your target