Aliases for SUPT5H Gene
Aliases for SUPT5H Gene
External Ids for SUPT5H Gene
- HGNC: 11469
- Entrez Gene: 6829
- Ensembl: ENSG00000196235
- OMIM: 602102
- UniProtKB: O00267
Previous GeneCards Identifiers for SUPT5H Gene
- GC19P040577
- GC19P040327
- GC19P044612
- GC19P044628
- GC19P039936
- GC19P036382
Summaries for SUPT5H Gene
GeneCards Summary for SUPT5H Gene
SUPT5H (SPT5 Homolog, DSIF Elongation Factor Subunit) is a Protein Coding gene. Diseases associated with SUPT5H include Hiv-1. Among its related pathways are HIV Life Cycle and mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding and chromatin binding.
UniProtKB/Swiss-Prot for SUPT5H Gene
-
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3 terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT5H Gene
Genomics for SUPT5H Gene
Regulatory Elements for SUPT5H Gene
Enhancers for SUPT5H Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SUPT5H on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SUPT5H gene promoter:
Regulatory Element Products
Genomic Location for SUPT5H Gene
- Chromosome:
- 19
- Start:
- 39,436,156 bp from pter
- End:
- 39,476,670 bp from pter
- Size:
- 40,515 bases
- Orientation:
- Plus strand
Genomic View for SUPT5H Gene
Genes around SUPT5H on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
SUPT5H Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SUPT5H Gene
Proteins for SUPT5H Gene
-
Protein details for SUPT5H Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00267-SPT5H_HUMAN
- Recommended name:
- Transcription elongation factor SPT5
- Protein Accession:
- O00267
- O43279
- Q59G52
- Q99639
Protein attributes for SUPT5H Gene
- Size:
- 1087 amino acids
- Molecular mass:
- 121000 Da
- Quaternary structure:
-
- Interacts with SUPT4H1 to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of WHSC2/NELFA, COBRA1/NELFB, TH1L/NELFD and RDBP/NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. DSIF also interacts with PRMT1/HRMT1L2, HTATSF1/TATSF1, RNGTT/CAP1A, PRMT5/SKB1, SUPT6H, and can interact with PIN1. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin.
- SequenceCaution:
-
- Sequence=BAD92494.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for SUPT5H Gene
Protein Expression for SUPT5H Gene
Post-translational modifications for SUPT5H Gene
- Methylated by PRMT1/HRMT1L2 and PRMT5/SKB1. Methylation negatively regulates interaction with P-TEFb and RNA polymerase II.
- Phosphorylated by CDK7 and CDK9. Phosphorylation by P-TEFb alleviates transcriptional pausing and can stimulate transcriptional elongation from the HIV-1 LTR. P-TEFb dependent phosphorylation is stimulated by the HIV-1 Tat protein. Phosphorylation may also stimulate interaction with PIN1. Bulk phosphorylation occurs predominantly in mitosis.
- Ubiquitination at Lys147, Lys199, isoforms=2213, posLast=306306, isoforms=2323, Lys650, and posLast=718718
- Modification sites at PhosphoSitePlus
Other Protein References for SUPT5H Gene
Antibody Products
- Cell Signaling Technology (CST) Antibodies for SUPT5H (SPT5)
- Novus Biologicals Antibodies for SUPT5H
- Invitrogen Antibodies for SUPT5H
- antibodies-online Antibodies for SUPT5H: See all 44
- Search GeneTex for Antibodies for SUPT5H
-
Santa Cruz Biotechnology (SCBT) Antibodies for SUPT5H
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SUPT5H
- Origene Custom Protein Services for SUPT5H
- Novus Biologicals proteins for SUPT5H
- antibodies-online Proteins for SUPT5H: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SUPT5H
Assay Products
- antibodies-online Kits for SUPT5H: See all 3
No data available for DME Specific Peptides for SUPT5H Gene
Domains & Families for SUPT5H Gene
Protein Domains for SUPT5H Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SUPT5H Gene
Graphical View of Domain Structure for InterPro Entry
O00267- Family:
-
- Belongs to the SPT5 family.
No data available for Gene Families for SUPT5H Gene
Function for SUPT5H Gene
Molecular function for SUPT5H Gene
- GENATLAS Biochemistry:
- putative chromatin structure regulator yeast Spt5 homolog,(histones group)
- UniProtKB/Swiss-Prot Function:
- Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3 terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 10075709 |
| GO:0019899 | enzyme binding | IPI | 10075709 |
| GO:0046982 | protein heterodimerization activity | IPI | 9450929 |
Phenotypes for SUPT5H Gene
- MGI mutant phenotypes for SUPT5H:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SUPT5H:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Negative genetic interaction between MUS81-/- and MUS81+/+
- shRNA abundance <= 50%
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Increased G1 DNA content
- G0/1 arrest
- Decreased IL-8 secretion
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased homologous recombination repair frequency
- Increased viability with MLN4924 (a NAE inhibitor)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability of wild-type and TP53 knockout cells
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Downregulation of NFkappaB pathway
Animal Models for SUPT5H Gene
- MGI Knock Outs for SUPT5H:
-
- Supt5 tm2a(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SUPT5H
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SUPT5H gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SUPT5H gene
- Search ViGene Biosciences for SUPT5H
CRISPR Products
-
OriGene CRISPR knockouts for SUPT5H
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUPT5H
- GenScript: Design CRISPR guide RNA sequences for SUPT5H
miRNA for SUPT5H Gene
- miRTarBase miRNAs that target SUPT5H
-
- hsa-mir-155-5p (MIRT020754)
- hsa-mir-34a-5p (MIRT025307)
- hsa-mir-26b-5p (MIRT029450)
- hsa-mir-1229-3p (MIRT036363)
- hsa-mir-935 (MIRT036670)
- hsa-mir-93-3p (MIRT038889)
- hsa-mir-92b-3p (MIRT040704)
- hsa-mir-484 (MIRT042043)
- hsa-mir-324-3p (MIRT042864)
- hsa-mir-149-5p (MIRT045555)
- hsa-mir-92a-3p (MIRT049464)
- hsa-mir-16-5p (MIRT051148)
miRNA Products
- Search ViGene Biosciences for SUPT5H
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for SUPT5H
- Browse OriGene Inhibitory RNA Products For SUPT5H
-
ViGene Biosciences ready-to-package AAV shRNAs for SUPT5H gene
Clone Products
- Sino Biological Human cDNA Clone for SUPT5H
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SUPT5H
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SUPT5H
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SUPT5H gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SUPT5H gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SUPT5H gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUPT5H Gene
Localization for SUPT5H Gene
Subcellular locations from UniProtKB/Swiss-Prot for SUPT5H Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 10075709 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0032044 | DSIF complex | IDA | 9450929 |
Pathways & Interactions for SUPT5H Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Formation of HIV elongation complex in the absence of HIV Tat | ||
| 2 | mRNA Capping |
.93
|
|
| 3 | HIV Life Cycle |
.92
.65
|
.45
|
| 4 | Gene Expression |
.48
|
|
| 5 | Chromatin Regulation / Acetylation | ||
Pathways by source for SUPT5H Gene
1 Cell Signaling Technology pathway for SUPT5H Gene
2 BioSystems pathways for SUPT5H Gene
Interacting Proteins for SUPT5H Gene
Selected Interacting proteins:
O00267-SPT5H_HUMAN
ENSP00000404029
for SUPT5H Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IDA | 9450929 |
| GO:0006338 | chromatin remodeling | NAS | 10075709 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006354 | DNA-templated transcription, elongation | IDA | 10075709 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
Transcripts for SUPT5H Gene
mRNA/cDNA for SUPT5H Gene
- (7) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (471) Selected AceView cDNA sequences:
- (20) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SUPT5H Gene
CRISPR Products
-
OriGene CRISPR knockouts for SUPT5H
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUPT5H
- GenScript: Design CRISPR guide RNA sequences for SUPT5H
miRNA Products
- Search ViGene Biosciences for SUPT5H
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for SUPT5H
- Browse OriGene Inhibitory RNA Products For SUPT5H
-
ViGene Biosciences ready-to-package AAV shRNAs for SUPT5H gene
Clone Products
- Sino Biological Human cDNA Clone for SUPT5H
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SUPT5H
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SUPT5H
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30a | · | 30b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||
| SP8: |
Expression for SUPT5H Gene
This gene is overexpressed in Peripheral blood mononuclear cells (13.3), CD8 Tcells (9.4), and Lymph node (9.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUPT5H Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SUPT5H Gene:
SUPT5HSOURCE GeneReport for Unigene cluster for SUPT5H Gene:
Hs.631604mRNA Expression by UniProt/SwissProt for SUPT5H Gene:
O00267-SPT5H_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for SUPT5H Gene
- Nervous system(5)
- Liver(4.3)
- Muscle(4.3)
- Pancreas(3.5)
- Lung(2.8)
- Blood(2.6)
Primer Products
-
OriGene qPCR primer pairs for SUPT5H
-
OriGene qPCR primer pairs and template standards for SUPT5H
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUPT5H Gene
Orthologs for SUPT5H Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SUPT5H 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SUPT5H 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SUPT5H 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SUPT5H 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SUPT5H 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Supt5h 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Supt5 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | SUPT5H 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SUPT5H 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | supt5h 34 |
|
||
| Str.2822 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5044 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | supt5h 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005021 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Spt5 36 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | spt-5 34 35 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADR187W 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B00891g 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPT5 34 35 37 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | GTA2 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0772000 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06929 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | spt5 34 |
|
- Species where no ortholog for SUPT5H was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SUPT5H Gene
No data available for Paralogs for SUPT5H Gene
Variants for SUPT5H Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000035407 | -- | 39,444,068(+) | CTGAC(-/CT)CGTGA | upstream-variant-2KB | |
| rs1000094731 | -- | 39,471,970(+) | GAGAA(C/T)CAGTG | intron-variant | |
| rs1000139640 | -- | 39,443,744(+) | CCAGG(A/C)TGGTC | upstream-variant-2KB | |
| rs1000207127 | -- | 39,449,222(+) | AGGAC(A/G)GTGAG | intron-variant | |
| rs1000275443 | -- | 39,447,020(+) | ATTAG(C/G)TGAGC | intron-variant |
Residual Variation Intolerance Score:
0.867% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.90;
35.41% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SUPT5H Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUPT5H Gene
Disorders for SUPT5H Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hiv-1 |
|
|
Search SUPT5H in MalaCards
View complete list of genes associated with diseases
Relevant External Links for SUPT5H
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- SUPT5H
No data available for UniProtKB/Swiss-Prot and Genatlas for SUPT5H Gene
Publications for SUPT5H Gene
- Structure and function of the human transcription elongation factor DSIF. (PMID: 10075709) Yamaguchi Y. … Handa H. (J. Biol. Chem. 1999) 2 3 4 22 64
- Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5. (PMID: 8975720) Chiang P.-W. … Kurnit D.M. (Genomics 1996) 2 3 4 22 64
- Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface. (PMID: 19860741) Wenzel S. … Wohrl B.M. (Biochem. J. 2010) 3 4 22 64
- Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. (PMID: 16327805) Larochelle S. … Fisher R.P. (Nat. Struct. Mol. Biol. 2006) 3 4 22 64
- Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. (PMID: 15060154) Endoh M. … Handa H. (Mol. Cell. Biol. 2004) 3 4 22 64
Products for SUPT5H Gene
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- Browse OriGene ELISA Kits
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- Search Origene for MassSpec and Protein Over-expression Lysates for SUPT5H
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for SUPT5H
- Browse OriGene Inhibitory RNA Products For SUPT5H
- OriGene qPCR primer pairs and template standards for SUPT5H
- OriGene qPCR primer pairs for SUPT5H
- OriGene CRISPR knockouts for SUPT5H
- OriGene ORF clones in human for SUPT5H
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- GenScript: Next-day shipping cDNA ORF clone for SUPT5H in any vector
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- GenScript: Design CRISPR guide RNA sequences for SUPT5H
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- Cell Signaling Technology (CST) Antibodies for SUPT5H (SPT5)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for SUPT5H
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for SUPT5H
- Novus Biologicals proteins for SUPT5H
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for SUPT5H
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for SUPT5H: See all 44
- antibodies-online Kits for SUPT5H: See all 3
- antibodies-online Proteins for SUPT5H: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for SUPT5H
- Search GeneTex for Proteins for SUPT5H
- ViGene Biosciences adenoviral particle packaged cDNA for SUPT5H gene
- ViGene Biosciences lentiviral particle packaged cDNA for SUPT5H gene
- ViGene Biosciences ready-to-package AAV shRNAs for SUPT5H gene
- Search ViGene Biosciences for SUPT5H
- Santa Cruz Biotechnology (SCBT) Antibodies for SUPT5H
- Search Santa Cruz Biotechnology (SCBT) for SUPT5H siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SUPT5H
- Cyagen custom Knockout/knockin (KOKI) mouse models for SUPT5H
- VectorBuilder custom plasmid, inducible vectors for SUPT5H
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SUPT5H
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SUPT5H Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer