Set Analyses:
GeneALaCart
GeneDecks
VarElect
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 


SUPT4H1 Gene

protein-coding   GIFtS: 57
GCID: GC17M056422

Suppressor Of Ty 4 Homolog 1 (S. Cerevisiae)

(Previous name: suppressor of Ty (S.cerevisiae) 4 homolog 1)
(Previous symbol: SUPT4H)
Microbiology & Infectious Diseases Congress
  See related diseases
at
MalaCards
 

Aliases
for SUPT4H1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus
Aliases
Suppressor Of Ty 4 Homolog 1 (S. Cerevisiae)1 2     SPT42
SUPT4H1 2 3     Small HSpt4 Subunit2
SPT4H2 3     Transcription Elongation Factor SPT42
DRB Sensitivity-Inducing Factor 14 KDa Subunit2 3     DRB Sensitivity-Inducing Factor Small Subunit3
DSIF P142 3     DSIF Small Subunit3
Suppressor Of Ty (S.Cerevisiae) 4 Homolog 11     hSPT43

External Ids:    HGNC: 114671   Entrez Gene: 68272   Ensembl: ENSG000002132467   OMIM: 6035555   UniProtKB: P632723   

Export aliases for SUPT4H1 gene to outside databases

Previous GC identifers: GC17M056166 GC17M058904 GC17M056764 GC17M056897 GC17M053777 GC17M051783


Summaries
for SUPT4H1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus
Entrez Gene summary for SUPT4H1 Gene:
This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing
factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The
encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF
complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript
variants have been found for this gene. (provided by RefSeq, Nov 2012)

GeneCards Summary for SUPT4H1 Gene:
SUPT4H1 (suppressor of Ty 4 homolog 1 (S. cerevisiae)) is a protein-coding gene. Diseases associated with SUPT4H1 include wolf-hirschhorn syndrome, and cockayne syndrome. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: SPT4H_HUMAN, P63272
Function: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing
and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA
guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor
complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional
pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote
pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at
transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked
transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow
repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional
elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear
transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the
HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences

Gene Wiki entry for SUPT4H1 Gene


Genomic Views
for SUPT4H1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUPT4H1 gene promoter:
         C/EBPbeta   Pax-5   p53   NF-kappaB   c-Ets-1   FOXI1   NF-kappaB2   FOXO1a   NF-kappaB1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SUPT4H1 promoter sequence
   Search Chromatin IP Primers for SUPT4H1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUPT4H1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21-q23   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q21-q23

SUPT4H1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUPT4H1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M056422:  view genomic region     (about GC identifiers)

Start:
 56,422,539 bp from pter      End:
 56,430,454 bp from pter
Size:
 7,916 bases      Orientation:
 minus strand

Proteins
for SUPT4H1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus
UniProtKB/Swiss-Prot: SPT4H_HUMAN, P63272 (See protein sequence)
Recommended Name: Transcription elongation factor SPT4  
Size: 117 amino acids; 13193 Da
Subunit: Interacts with SUPT5H to form DSIF. DSIF interacts with the positive transcription elongation factor b
complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA
polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by
P-TEFb. DSIF also interacts with the NELF complex, which is composed of WHSC2/NELFA, COBRA1/NELFB, TH1L/NELFD and
RDBP/NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. DSIF also interacts
with HRMT1L2/PRMT1, HTATSF1/TATSF1, RNGTT/CAP1A, SKB1/PRMT5, SUPT6H, and can interact with PIN1
1 PDB 3D structure from and Proteopedia for SUPT4H1:
3H7H (3D)    
Secondary accessions: B2R4X8 D3DTZ4 Q16550 Q62387 Q6ZP89

Explore the universe of human proteins at neXtProt for SUPT4H1: NX_P63272

Explore proteomics data for SUPT4H1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys43, Lys81
  • Modification sites at PhosphoSitePlus

    • See SUPT4H1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003159.1  
    ENSEMBL proteins: 
     ENSP00000463979   ENSP00000225504   ENSP00000462100   ENSP00000464618   ENSP00000462670  
     ENSP00000462602  
    Reactome Protein details: P63272

    SUPT4H1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SUPT4H1
    OriGene Protein Over-expression Lysate for SUPT4H1
    OriGene MassSpec for SUPT4H1
    OriGene Custom Protein Services for SUPT4H1
    GenScript Custom Purified and Recombinant Proteins Services for SUPT4H1
    Novus Biologicals SUPT4H1 Proteins
    Novus Biologicals SUPT4H1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUPT4H1

    SUPT4H1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SUPT4H1
    OriGene Custom Antibody Services for SUPT4H1
    Novus Biologicals SUPT4H1 Antibodies
    Abcam antibodies for SUPT4H1
    Cloud-Clone Corp. Antibodies for SUPT4H1
    Search ThermoFisher Antibodies for SUPT4H1
    LSBio Antibodies in human, mouse, rat for SUPT4H1

    SUPT4H1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SUPT4H1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SUPT4H1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SUPT4H1
    Cloud-Clone Corp. CLIAs for SUPT4H1

    Domains /
    Families
    for SUPT4H1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 3 InterPro protein domains:
     IPR022800 Spt4/RpoE2_Znf
     IPR016046 Spt4-like
     IPR009287 Spt4

    Graphical View of Domain Structure for InterPro Entry P63272

    ProtoNet protein and cluster: P63272

    1 Blocks protein domain: IPB009287 Transcription initiation Spt4

    UniProtKB/Swiss-Prot: SPT4H_HUMAN, P63272
    Similarity: Belongs to the SPT4 family


    SUPT4H1 for domains           About GeneDecksing


    Function
    for SUPT4H1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPT4H_HUMAN, P63272
    Function: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing
    and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA
    guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor
    complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional
    pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote
    pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at
    transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked
    transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow
    repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional
    elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear
    transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the
    HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences

         Genatlas biochemistry entry for SUPT4H1:
    putative chromatin structure regulator,yeast spt4 (suppressor of Ty) homolog,ubiquitously expressed

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8649394
    GO:0005515protein binding IPI10075709
    GO:0008270zinc ion binding IEA--
    GO:0046982protein heterodimerization activity IPI9450929
         
    SUPT4H1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SUPT4H1:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUPT4H1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SUPT4H1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUPT4H1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUPT4H1

    miRNA
    Products:            		miRTarBase miRNAs that target SUPT4H1:
    hsa-mir-7-5p (MIRT025924), hsa-let-7e-5p (MIRT051537), hsa-mir-96-5p (MIRT027878)

    Block miRNA regulation of human, mouse, rat SUPT4H1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate SUPT4H1:
    hsa-miR-148b* hsa-miR-544b hsa-miR-532-3p hsa-miR-1260b hsa-miR-580 hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmid: SUPT4H1 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for SUPT4H1
    Predesigned siRNA for gene silencing in human, mouse, rat SUPT4H1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SUPT4H1

    Clone
    Products:             		 OriGene clones in human, mouse for SUPT4H1 (see all 7)
    OriGene ORF clones in mouse, rat for SUPT4H1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SUPT4H1 (NM_003168)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUPT4H1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUPT4H1

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SUPT4H1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SUPT4H1 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT4H1


    Localization
    for SUPT4H1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Subcellular locations from UniProtKB/Swiss-Prot
    SPT4H_HUMAN, P63272: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0032044DSIF complex IDA9450929

    SUPT4H1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for SUPT4H1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SUPT4H1 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    		Formation of the Early Elongation Complex0.77
    		RNA Polymerase II Pre-transcription Events0.73
    		Formation of the HIV-1 Early Elongation Complex0.77
    		Pausing and recovery of HIV elongation0.73
    		Formation of HIV-1 elongation complex containing HIV-1 Tat0.77
    		HIV elongation arrest and recovery0.73
    		Tat-mediated elongation of the HIV-1 transcript0.77
    		Pausing and recovery of Tat-mediated HIV elongation0.72
    2HIV Life Cycle
    		HIV Life Cycle0.91
    		HIV Infection0.62
    		Late Phase of HIV Life Cycle0.91
    3Gene Expression
    		Gene Expression0.40
    4Disease
    		Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for SUPT4H1 (see all 13)
        Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Formation of the Early Elongation Complex
    Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript



    SUPT4H1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SUPT4H1
    Interactions:

        Search GeneGlobe Interaction Network for SUPT4H1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUPT4H1 (P632721, 2, 3 ENSP000002255044) via UniProtKB, MINT, STRING, and/or I2D (see all 232)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMP19Q9Y3282, 3, ENSP000003077224MINT-8272388 I2D: score=2 STRING: ENSP00000307722
    SUPT5HO002671, 3EBI-727250,EBI-710464 I2D: score=5 
    LRIF1Q5T3J32, 3MINT-8272377 I2D: score=2 
    PDLIM1O001512, 3, ENSP000003603054MINT-8272399 I2D: score=2 STRING: ENSP00000360305
    ANXA5P087582, 3, ENSP000002965114MINT-64710 I2D: score=4 STRING: ENSP00000296511
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA9450929
    GO:0006338chromatin remodeling TAS8649394
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated TAS8786137
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8649394

    SUPT4H1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SUPT4H1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUPT4H1 (SPT4H)



    Transcripts
    for SUPT4H1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus
    REFSEQ mRNAs for SUPT4H1 gene: 
    NM_003168.2  

    Unigene Cluster for SUPT4H1:

    Suppressor of Ty 4 homolog 1 (S. cerevisiae)
    Hs.439481  [show with all ESTs]
    Unigene Representative Sequence: BM543526
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000581166 ENST00000225504(uc002iwe.1) ENST00000577396 ENST00000581204
    ENST00000581540 ENST00000580947 ENST00000579289
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat SUPT4H1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate SUPT4H1:
    hsa-miR-148b* hsa-miR-544b hsa-miR-532-3p hsa-miR-1260b hsa-miR-580 hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmid: SUPT4H1 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for SUPT4H1
    Predesigned siRNA for gene silencing in human, mouse, rat SUPT4H1
    Clone
    Products:             		 OriGene clones in human, mouse for SUPT4H1 (see all 7)
    OriGene ORF clones in mouse, rat for SUPT4H1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SUPT4H1 (NM_003168)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUPT4H1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUPT4H1
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for SUPT4H1
    OriGene qSTAR qPCR primer pairs in human, mouse for SUPT4H1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUPT4H1
      QuantiTect SYBR Green Assays in human, mouse, rat SUPT4H1
      QuantiFast Probe-based Assays in human, mouse, rat SUPT4H1

    Additional mRNA sequence: 

    AK129758.1 AK311986.1 BC002802.2 CR407663.1 NR_073470.1 U38817.1 U38818.1 U43923.1 

    15 DOTS entries:

    DT.454444  DT.100878569  DT.92443169  DT.100723596  DT.92443173  DT.100878567  DT.100878570  DT.95163091 
    DT.120989080  DT.120989095  DT.121140409  DT.95144558  DT.95163095  DT.95203281  DT.99942914 

    Selected AceView cDNA sequences (see all 568):

    CA442492 BQ020356 BU738819 AI392769 BE617199 BP370868 BX950905 AA310551 
    BQ018762 BX951329 CB112138 AA297623 BQ011725 AA337910 BQ012821 AA669239 
    AU099670 BX951256 BQ224372 BQ574860 CA444131 BQ647050 AI871164 AI612846 

    GeneLoc Exon Structure


    Expression
    for SUPT4H1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SUPT4H1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAGGACTC
    SUPT4H1 Expression
    About this image

    SUPT4H1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    SUPT4H1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.439481

    UniProtKB/Swiss-Prot: SPT4H_HUMAN, P63272
    Tissue specificity: Widely expressed

        Custom PCR Arrays for SUPT4H1
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for SUPT4H1
    OriGene qSTAR qPCR primer pairs in human, mouse for SUPT4H1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUPT4H1
    QuantiTect SYBR Green Assays in human, mouse, rat SUPT4H1
    QuantiFast Probe-based Assays in human, mouse, rat SUPT4H1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT4H1

    Orthologs
    for SUPT4H1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SUPT4H1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Supt4a1 , 5 suppressor of Ty 4 homolog 1 (S. cerevisiae)5
    suppressor of Ty 4A1    		 94.87(n)1
    100(a)1    		   11 (52.20 cM)5
    209221  NM_009296.11  NP_033322.11 
     877375525 
    chicken
    (Gallus gallus)    		 Aves SUPT4H11 suppressor of Ty 4 homolog 1 (S. cerevisiae) 81.77(n)
    97.44(a)    		   417470  NM_001257286.1  NP_001244215.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.237552 Xenopus laevis transcribed sequence with strong similarity more 80.56(n)    48062282 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.293152 Transcribed sequence with moderate similarity to protein more 79.33(n)    57051618 
    fruit fly
    (Drosophila melanogaster)    		 Insecta spt41 , 3 non-covalent chromatin modification
    chromatin more3
    spt41    		 62(a)3
    63.1(n)1
    62.5(a)1    		   49B103
    363871  NM_136958.51  NP_610802.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea spt-41 , 3 spt-41 58(a)3
    57.46(n)1
    58.1(a)1    		   III(68628-69765)3
    1751721  NM_064734.41  NP_497135.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SPT4(YGR063C)4 Protein involved in the regulating Pol I and Pol II more   --   7(617824-617516) 852955  NP_011577.1 


    ENSEMBL Gene Tree for SUPT4H1 (if available)
    TreeFam Gene Tree for SUPT4H1 (if available)

    Paralogs
    for SUPT4H1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SUPT4H1 gene

    SUPT4H1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SUPT4H1
    PGOHUM00000239323 PGOHUM00000240102


    Genomic Variants
    for SUPT4H1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus    		Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SUPT4H1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509663CNV Insertion20534489
    nsv819948CNV Loss19587683
    nsv908641CNV Loss21882294
    nsv517229CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUPT4H1
    DNA2.0 Custom Variant and Variant Library Synthesis for SUPT4H1

    Disorders / Diseases
    for SUPT4H1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603555    OMIM disorders: --

    4 diseases for SUPT4H1:    
    About MalaCards
    wolf-hirschhorn syndrome    cockayne syndrome    hiv-1    malaria

    2 diseases from the University of Copenhagen DISEASES database for SUPT4H1:
    Cockayne syndrome     Wolf-Hirschhorn syndrome

    SUPT4H1 for disorders           About GeneDecksing


    Export disorders for SUPT4H1 gene to outside databases

    Publications
    for SUPT4H1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus
    PubMed articles for SUPT4H1 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with SUPT4H1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene. (PubMed id 8786137)1, 2, 3 Chiang P.-W.... Kurnit D.M. (Genomics 1996)
    2. Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae. (PubMed id 8649394)1, 2, 9 Hartzog G.A....Winston F. (Mol. Cell. Biol. 1996)
    3. DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. (PubMed id 9450929)1, 2, 9 Wada T....Handa H. (Genes Dev. 1998)
    4. Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface. (PubMed id 19860741)1, 2 Wenzel S.... Wohrl B.M. (Biochem. J. 2010)
    5. A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS. (PubMed id 16214896)1, 2 Palangat M.... Landick R. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    6. Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. (PubMed id 15060154)1, 2 Endoh M.... Handa H. (Mol. Cell. Biol. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila. (PubMed id 15380072)1, 2 Jennings B.H.... Ish-Horowicz D. (Curr. Biol. 2004)
    10. Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II. (PubMed id 15136722)1, 2 Mandal S.S.... Reinberg D. (Proc. Natl. Acad. Sci. U.S.A. 2004)

    External Searches for SUPT4H1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SUPT4H1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6827 HGNC: 11467 AceView: SUPT4H1andFLJ20315 Ensembl:ENSG00000213246 euGenes: HUgn6827
    ECgene: SUPT4H1 H-InvDB: SUPT4H1

    Other Databases showing SUPT4H1 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing SUPT4H1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SUPT4H1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SUPT4H1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SUPT4H1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for SUPT4H1 gene:
    Search GeneIP for patents involving SUPT4H1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SUPT4H1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SUPT4H1   OriGene RNAi products in human, mouse, rat for SUPT4H1  
     OriGene qPCR primer pairs and template standards for SUPT4H1   OriGene Protein Over-expression Lysate for SUPT4H1  
     OriGene MassSpec something-or-other for SUPT4H1   OriGene clones in human, mouse for SUPT4H1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SUPT4H1   OriGene Purified Protein for SUPT4H1  
     OriGene ORF clones in mouse, rat for SUPT4H1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SUPT4H1   OriGene Custom Protein Services for SUPT4H1  

         		 
     Block miRNA regulation of human, mouse, rat SUPT4H1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SUPT4H1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUPT4H1 Predesigned siRNA for gene silencing in human, mouse, rat SUPT4H1
     QuantiFast Probe-based Assays in human, mouse, rat SUPT4H1 QuantiTect SYBR Green Assays in human, mouse, rat SUPT4H1
     Custom PCR Arrays for SUPT4H1 Search Chromatin IP Primers for SUPT4H1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUPT4H1  Search GeneGlobe Interaction Network for SUPT4H1
     Regulatory tfbs in SUPT4H1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SUPT4H1 GenScript cDNA clones with any tag delivered in your preferred vector for SUPT4H1
     GenScript Custom Assay Services for SUPT4H1 GenScript Custom overexpressing Cell Line Services for SUPT4H1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SUPT4H1 (SPT4H)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SUPT4H1 antibodies
     SUPT4H1 proteins
     SUPT4H1 lysates
     Antibodies for SUPT4H1
     See all of Abcam's Antibodies, Kits and Proteins for SUPT4H1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SUPT4H1
     Antibodies for SUPT4H1
     ELISAs for SUPT4H1
     CLIAs for SUPT4H1



     Browse ESI BIO Cell Lines and PureStem Progenitors for SUPT4H1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT4H1
     SwitchGear 3'UTR luciferase reporter plasmids for SUPT4H1
     SwitchGear Promoter luciferase reporter plasmids for SUPT4H1
     Search ThermoFisher Antibodies for SUPT4H1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUPT4H1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUPT4H1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SUPT4H1
     LSBio Antibodies in human, mouse, rat for SUPT4H1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SUPT4H1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4