Aliases for SUPT4H1 Gene
Aliases for SUPT4H1 Gene
External Ids for SUPT4H1 Gene
- HGNC: 11467
- Entrez Gene: 6827
- Ensembl: ENSG00000213246
- OMIM: 603555
- UniProtKB: P63272
Previous HGNC Symbols for SUPT4H1 Gene
- SUPT4H
Previous GeneCards Identifiers for SUPT4H1 Gene
- GC17M056166
- GC17M058904
- GC17M056764
- GC17M056897
- GC17M053777
- GC17M056422
- GC17M051783
Summaries for SUPT4H1 Gene
-
This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
GeneCards Summary for SUPT4H1 Gene
SUPT4H1 (SPT4 Homolog, DSIF Elongation Factor Subunit) is a Protein Coding gene. Diseases associated with SUPT4H1 include Hiv-1. Among its related pathways are HIV Life Cycle and Formation of HIV elongation complex in the absence of HIV Tat. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity.
UniProtKB/Swiss-Prot for SUPT4H1 Gene
-
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3 terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT4H1 Gene
Genomics for SUPT4H1 Gene
Regulatory Elements for SUPT4H1 Gene
Enhancers for SUPT4H1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SUPT4H1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SUPT4H1 gene promoter:
Regulatory Element Products
Genomic Location for SUPT4H1 Gene
- Chromosome:
- 17
- Start:
- 58,345,175 bp from pter
- End:
- 58,353,093 bp from pter
- Size:
- 7,919 bases
- Orientation:
- Minus strand
Genomic View for SUPT4H1 Gene
Genes around SUPT4H1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q22 by Ensembl
- 17q22 by Entrez Gene
- 17q22 by HGNC
SUPT4H1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SUPT4H1 Gene
Proteins for SUPT4H1 Gene
-
Protein details for SUPT4H1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P63272-SPT4H_HUMAN
- Recommended name:
- Transcription elongation factor SPT4
- Protein Accession:
- P63272
- B2R4X8
- D3DTZ4
- Q16550
- Q62387
- Q6ZP89
Protein attributes for SUPT4H1 Gene
- Size:
- 117 amino acids
- Molecular mass:
- 13193 Da
- Quaternary structure:
-
- Interacts with SUPT5H to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of WHSC2/NELFA, COBRA1/NELFB, TH1L/NELFD and RDBP/NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. DSIF also interacts with HRMT1L2/PRMT1, HTATSF1/TATSF1, RNGTT/CAP1A, SKB1/PRMT5, SUPT6H, and can interact with PIN1.
Protein Expression for SUPT4H1 Gene
Post-translational modifications for SUPT4H1 Gene
Other Protein References for SUPT4H1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for SUPT4H1 (SUPT4H1)
- Novus Biologicals Antibodies for SUPT4H1
-
Abcam antibodies for SUPT4H1
- antibodies-online Antibodies for SUPT4H1: See all 18
- GeneTex SUPT4H1 antibody for SUPT4H1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SUPT4H1
Protein Products
-
OriGene Purified Proteins for SUPT4H1
- Search Origene for MassSpec and Protein Over-expression Lysates for SUPT4H1
- Origene Custom Protein Services for SUPT4H1
- antibodies-online Proteins for SUPT4H1: See all 17
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SUPT4H1
-
Abcam proteins for SUPT4H1
No data available for DME Specific Peptides for SUPT4H1 Gene
Domains & Families for SUPT4H1 Gene
Protein Domains for SUPT4H1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SUPT4H1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P63272- Family:
-
- Belongs to the SPT4 family.
No data available for Gene Families for SUPT4H1 Gene
Function for SUPT4H1 Gene
Molecular function for SUPT4H1 Gene
- GENATLAS Biochemistry:
- putative chromatin structure regulator,yeast spt4 (suppressor of Ty) homolog,ubiquitously expressed
- UniProtKB/Swiss-Prot Function:
- Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3 terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000993 | RNA polymerase II core binding | IBA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | TAS | 8649394 |
| GO:0003727 | single-stranded RNA binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 10075709 |
| GO:0008270 | zinc ion binding | IEA | -- |
Phenotypes for SUPT4H1 Gene
- MGI mutant phenotypes for SUPT4H1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SUPT4H1:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased NF-kappaB reporter expression
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Synthetic lethal with vaccinia virus (VACV) infection
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SUPT4H1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SUPT4H1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SUPT4H1 gene
- Search ViGene Biosciences for SUPT4H1
CRISPR Products
-
OriGene CRISPR knockouts for SUPT4H1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUPT4H1
- GenScript: Design CRISPR guide RNA sequences for SUPT4H1
miRNA for SUPT4H1 Gene
- miRTarBase miRNAs that target SUPT4H1
miRNA Products
- Search ViGene Biosciences for SUPT4H1
Inhibitory RNA Products
- Origene siRNA, mouse_rna, shRNA, and RNAi products in human, mouse, rat for SUPT4H1
- Browse OriGene Inhibitory RNA Products For SUPT4H1
-
ViGene Biosciences ready-to-package AAV shRNAs for SUPT4H1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SUPT4H1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SUPT4H1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SUPT4H1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SUPT4H1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SUPT4H1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUPT4H1 Gene
Localization for SUPT4H1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SUPT4H1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,TAS | 8649394 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0032044 | DSIF complex | IDA | 9450929 |
Pathways & Interactions for SUPT4H1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Formation of HIV elongation complex in the absence of HIV Tat | ||
| 2 | HIV Life Cycle |
.92
.65
|
.45
|
| 3 | mRNA Capping | ||
| 4 | Gene Expression |
.48
|
|
| 5 | Chromatin Regulation / Acetylation | ||
Pathways by source for SUPT4H1 Gene
1 Cell Signaling Technology pathway for SUPT4H1 Gene
1 BioSystems pathway for SUPT4H1 Gene
Interacting Proteins for SUPT4H1 Gene
Selected Interacting proteins:
P63272-SPT4H_HUMAN
ENSP00000225504
for SUPT4H1 Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IDA | 9450929 |
| GO:0006338 | chromatin remodeling | TAS | 8649394 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | TAS | 8786137 |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | TAS | 8649394 |
No data available for SIGNOR curated interactions for SUPT4H1 Gene
Transcripts for SUPT4H1 Gene
mRNA/cDNA for SUPT4H1 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (568) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SUPT4H1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SUPT4H1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUPT4H1
- GenScript: Design CRISPR guide RNA sequences for SUPT4H1
miRNA Products
- Search ViGene Biosciences for SUPT4H1
Inhibitory RNA Products
- Origene siRNA, mouse_rna, shRNA, and RNAi products in human, mouse, rat for SUPT4H1
- Browse OriGene Inhibitory RNA Products For SUPT4H1
-
ViGene Biosciences ready-to-package AAV shRNAs for SUPT4H1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SUPT4H1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SUPT4H1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for SUPT4H1 Gene
mRNA differential expression in normal tissues according to GTEx for SUPT4H1 Gene
This gene is overexpressed in Whole Blood (x4.9).
This gene is overexpressed in Breast (14.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUPT4H1 Gene
NURSA nuclear receptor signaling pathways regulating expression of SUPT4H1 Gene:
SUPT4H1SOURCE GeneReport for Unigene cluster for SUPT4H1 Gene:
Hs.439481mRNA Expression by UniProt/SwissProt for SUPT4H1 Gene:
P63272-SPT4H_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for SUPT4H1 Gene
- Nervous system(3.4)
- Lung(2.2)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for SUPT4H1
-
OriGene qPCR primer pairs and template standards for SUPT4H1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUPT4H1 Gene
Orthologs for SUPT4H1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SUPT4H1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | SUPT4H1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Supt4a 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SUPT4H1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Supt4h1 34 |
|
||
| chicken (Gallus gallus) |
Aves | SUPT4H1 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | supt4h1 34 |
|
||
| Str.5867 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23755 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | supt4h1 34 35 |
|
||
| Dr.29315 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1288 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005428 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | spt4 36 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | spt-4 36 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPT4 35 37 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5304 35 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03838 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.956 34 |
|
- Species where no ortholog for SUPT4H1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SUPT4H1 Gene
Pseudogenes.org Pseudogenes for SUPT4H1 Gene
No data available for Paralogs for SUPT4H1 Gene
Variants for SUPT4H1 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000187834 | -- | 58,348,264(+) | TAAGC(A/G)TTTTT | intron-variant | |
| rs1000195216 | -- | 58,350,298(+) | CACGA(A/G)GTCAG | intron-variant | |
| rs1000416541 | -- | 58,350,809(+) | CCAGC(A/G)TGAGT | intron-variant | |
| rs1001197581 | -- | 58,353,982(+) | CCTGT(-/G)GGTCC | intron-variant, upstream-variant-2KB, utr-variant-3-prime | |
| rs1001355375 | -- | 58,345,132(+) | ATTTT(-/G)GCTGA | intron-variant, downstream-variant-500B |
Residual Variation Intolerance Score:
48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.17;
3.84% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SUPT4H1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SUPT4H1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUPT4H1 Gene
Disorders for SUPT4H1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hiv-1 |
|
|
Search SUPT4H1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for SUPT4H1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- SUPT4H1
No data available for UniProtKB/Swiss-Prot and Genatlas for SUPT4H1 Gene
Publications for SUPT4H1 Gene
- Structure and function of the human transcription elongation factor DSIF. (PMID: 10075709) Yamaguchi Y. … Handa H. (J. Biol. Chem. 1999) 2 3 4 64
- DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. (PMID: 9450929) Wada T. … Handa H. (Genes Dev. 1998) 3 4 22 64
- Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae. (PMID: 8649394) Hartzog G.A. … Winston F. (Mol. Cell. Biol. 1996) 3 4 22 64
- Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene. (PMID: 8786137) Chiang P.-W. … Kurnit D.M. (Genomics 1996) 2 3 4 64
- Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface. (PMID: 19860741) Wenzel S. … Wohrl B.M. (Biochem. J. 2010) 3 4 64
Products for SUPT4H1 Gene
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- Custom Antibody ServicesOriGene Antibodies for SUPT4H1
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- Novus Biologicals
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- antibodies-online Antibodies for SUPT4H1: See all 18
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- antibodies-online Proteins for SUPT4H1: See all 17
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- GeneTex SUPT4H1 antibody for SUPT4H1
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- ViGene Biosciences adenoviral particle packaged cDNA for SUPT4H1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SUPT4H1 gene
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- Search ViGene Biosciences for SUPT4H1
- Santa Cruz Biotechnology (SCBT) Antibodies for SUPT4H1
- Search Santa Cruz Biotechnology (SCBT) for SUPT4H1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SUPT4H1
- Cyagen custom Knockout/knockin (KOKI) mouse models for SUPT4H1
- VectorBuilder custom plasmid, inducible vectors for SUPT4H1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SUPT4H1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SUPT4H1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
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