SUPT4H1 Gene
protein-coding GIFtS: 57
GCID: GC17M056422
|
|
suppressor of Ty 4 homolog 1 (S. cerevisiae)(Previous name: suppressor of Ty (S.cerevisiae) 4 homolog 1 )
(Previous symbol: SUPT4H)
| |
Aliases
for SUPT4H1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Suppressor Of Ty 4 Homolog 1 (S. Cerevisiae)1 2 | | SPT42 | | SPT4H1 2 3 | | Small HSpt4 Subunit2 | | SUPT4H1 2 3 | | Transcription Elongation Factor SPT42 | | DRB Sensitivity-Inducing Factor 14 KDa Subunit2 3 | | DRB Sensitivity-Inducing Factor Small Subunit3 | | DSIF P142 3 | | DSIF Small Subunit3 | | Suppressor Of Ty (S.Cerevisiae) 4 Homolog 11 | | HSPT41 |
Export aliases for SUPT4H1 gene to outside databasesPrevious GC identifers: GC17M056166 GC17M058904 GC17M056764 GC17M056897 GC17M053777 GC17M051783 |
Summaries
for SUPT4H1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SUPT4H1:
This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducingfactor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encodedprotein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Relatedpseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been foundfor this gene. (provided by RefSeq, Nov 2012)
UniProtKB/Swiss-Prot: SPT4H_HUMAN, P63272Function: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing andtranscription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNAguanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex(NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing mayfacilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing byinhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcriptionpause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNApolymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts attranscription through natural pause sites. DSIF can also positively regulate transcriptional elongation and isrequired for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator,Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks prematurerelease of HIV-1 transcripts at terminator sequences
Gene Wiki entry for SUPT4H1
|
Genomic Views
for SUPT4H1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SUPT4H1 gene promoter:
C/EBPbeta Pax-5 p53 NF-kappaB c-Ets-1 FOXI1 NF-kappaB2 FOXO1a NF-kappaB1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SUPT4H1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUPT4H1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21-q23 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q21-q23SUPT4H1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M056422: view genomic region
(about GC identifiers)
Start:
|
56,422,539 bp from pter |
End:
|
56,430,454 bp from pter |
Size:
|
7,916 bases |
Orientation:
|
minus strand |
|
Proteins
for SUPT4H1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPT4H_HUMAN, P63272 (See
protein sequence)Recommended Name: Transcription elongation factor SPT4 Size: 117 amino acids; 13193 Da
Subunit: Interacts with SUPT5H to form DSIF. DSIF interacts with the positive transcription elongation factor b complex(P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, andthis interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interactswith the NELF complex, which is composed of WHSC2/NELFA, COBRA1/NELFB, TH1L/NELFD and RDBP/NELFE, and this interactionoccurs following prior binding of DSIF to RNA polymerase II. DSIF also interacts with HRMT1L2/PRMT1, HTATSF1/TATSF1,RNGTT/CAP1A, SKB1/PRMT5, SUPT6H, and can interact with PIN1
Subcellular location: Nucleus
1 PDB 3D structure from  and Proteopedia  for SUPT4H1:3H7H (3D)
Secondary accessions: B2R4X8 D3DTZ4 Q16550 Q62387 Q6ZP89Explore the universe of human proteins at neXtProt for SUPT4H1: NX_P63272
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P63272
SUPT4H1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003159.1
ENSEMBL proteins: ENSP00000463979 ENSP00000225504 ENSP00000462100 ENSP00000464618 ENSP00000462670 ENSP00000462602 Reactome Protein details: P63272
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SUPT4H1 for ontologies About GeneDecksing
SUPT4H1 Antibody Products:
Assay Products for SUPT4H1: |
Protein
Domains /
Families
for SUPT4H1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SUPT4H1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P63272ProtoNet protein and cluster: P63272 1 Blocks protein family: IPB009287 Transcription initiation Spt4
UniProtKB/Swiss-Prot: SPT4H_HUMAN, P63272Similarity: Belongs to the SPT4 family |
Function
for SUPT4H1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPT4H_HUMAN, P63272Function: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing andtranscription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNAguanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex(NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing mayfacilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing byinhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcriptionpause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNApolymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts attranscription through natural pause sites. DSIF can also positively regulate transcriptional elongation and isrequired for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator,Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks prematurerelease of HIV-1 transcripts at terminator sequences Genatlas biochemistry entry for SUPT4H1:putative chromatin structure regulator,yeast spt4 (suppressor of Ty) homolog,ubiquitously expressed
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUPT4H1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: SUPT4H1 (NM_003168) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SUPT4H1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUPT4H1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT4H1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SUPT4H1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SUPT4H1:
|
Pathways & Interactions
for SUPT4H1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Formation of RNA Pol II elongation complex | | | 2 | Late Phase of HIV Life Cycle | | | 3 | Transcription | | | 4 | HIV Infection | | | 5 | Disease | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/23 
Reactome Pathways for SUPT4H1 (see all 23)
SUPT4H1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SUPT4H1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/99 Interacting proteins for SUPT4H1 (P632721, 2, 3 ENSP000002255044) via UniProtKB, MINT, STRING, and/or I2D (see all 99)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
SUPT4H1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SUPT4H1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SUPT4H1
Search CenterWatch for drugs/clinical trials and news about SUPT4H1 / SPT4H
|
Transcripts
for SUPT4H1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SUPT4H1 gene: NM_003168.2 Unigene Cluster for SUPT4H1: Suppressor of Ty 4 homolog 1 (S. cerevisiae) Hs.439481 [show with all ESTs]Unigene Representative Sequence: BM5435267 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000581166 ENST00000225504(uc002iwe.1) ENST00000577396 ENST00000581204
ENST00000581540 ENST00000580947 ENST00000579289
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUPT4H1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUPT4H1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SUPT4H1 (NM_003168) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SUPT4H1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUPT4H1 |
Additional cDNA sequence: AK129758.1 AK311986.1 BC002802.2 CR407663.1 NR_073470.1 U38817.1 U38818.1 U43923.1 15 DOTS entries: DT.454444 DT.100878569 DT.92443169 DT.100723596 DT.92443173 DT.100878567 DT.100878570 DT.95163091 DT.120989080 DT.120989095 DT.121140409 DT.95144558 DT.95163095 DT.95203281 DT.99942914 24/568 AceView cDNA sequences (see all 568): CA442492 BU738819 BQ020356 AI392769 BP370868 BX950905 BE617199 BX951329 BQ018762 AA310551 CB112138 AA297623 AA337910 BQ012821 BQ011725 BQ224372 BQ574860 AA669239 AU099670 BX951256 CA444131 BQ647050 AI871164 AI612846
GeneLoc Exon Structure
|
Expression
for SUPT4H1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SUPT4H1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAAGGACTC
About this image
See SUPT4H1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SUPT4H1
SOURCE GeneReport for Unigene cluster: Hs.439481
UniProtKB/Swiss-Prot: SPT4H_HUMAN, P63272Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for SUPT4H1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUPT4H1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SUPT4H1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUPT4H1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUPT4H1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT4H1 |
Orthologs
for SUPT4H1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SUPT4H1 gene from 8/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Supt4a5
Supt4h11 |
suppressor of Ty 4 homolog 1 (S. cerevisiae)1, 5 |
94.87(n)1
100(a)1 |
|
11 (52.20 cM)5
209221 NM_009296.11 NP_033322.11
877375525 |
chicken
(Gallus gallus) |
Aves |
SUPT4H11 |
suppressor of Ty 4 homolog 1 (S. cerevisiae) |
81.77(n)
97.44(a) |
|
417470 XM_003642375.1 XP_003642423.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.237552 |
Xenopus laevis transcribed sequence with strong similarity more |
80.56(n) |
|
48062282 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.293152 |
Transcribed sequence with moderate similarity to protein more |
79.33(n) |
|
57051618 |
fruit fly
(Drosophila melanogaster) |
Insecta |
spt41 , 3 |
non-covalent chromatin modification
chromatin more3
CG12372-PA1 |
62(a)3
63.1(n)1
62.5(a)1 |
|
49B103
363871 NM_136958.41 NP_610802.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
spt-41 , 3 |
Protein SPT-41 |
58(a)3
57.46(n)1
58.1(a)1 |
|
III(68628-69765)3
1751721 NM_064734.31 NP_497135.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SPT426AT5G085656 |
transcription elongation factor SPT4-1 |
35(a)28(a) |
many → 1many → 1 |
5(25487927-25489428) 5(2775897-2777446) |
rice
(Oryza sativa) |
Liliopsida |
-- |
transcription elongation factor SPT4 homolog 1, pu... |
29(a) |
1 ↔ 1 |
7(25796885-25799784) |
ENSEMBL Gene Tree for SUPT4H1 (if available)
TreeFam Gene Tree for SUPT4H1 (if available) |
Paralogs
for SUPT4H1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SUPT4H1 gene
SUPT4H1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for SUPT4H1
PGOHUM00000239323 PGOHUM00000240102
|
Genomic Variants
for SUPT4H1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SUPT4H1 (56422539 - 56430454 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SUPT4H1
3 CNVs: 4410 58809 49893 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SUPT4H1 |
|
Disorders
/ Diseases
for SUPT4H1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SUPT4H1 for disorders About GeneDecksing
OMIM gene information: 603555
OMIM disorders: --
3  diseases for SUPT4H1: About MalaCardswolf-hirschhorn syndrome cockayne syndrome malaria
2 diseases from the University of Copenhagen DISEASES database for SUPT4H1:Cockayne syndrome Wolf-Hirschhorn syndrome Export disorders for SUPT4H1 gene to outside databases
|
Publications
for SUPT4H1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SUPT4H1 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with SUPT4H1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene. (PubMed id 8786137)1, 2, 3 Chiang P.-W.... Kurnit D.M. (1996)
- Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae. (PubMed id 8649394)1, 2, 9 Hartzog G.A....Winston F. (1996)
- DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. (PubMed id 9450929)1, 2, 9 Wada T....Handa H. (1998)
- A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS. (PubMed id 16214896)1, 2 Palangat M.... Landick R. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. (PubMed id 15060154)1, 2 Endoh M.... Handa H. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila. (PubMed id 15380072)1, 2 Jennings B.H.... Ish-Horowicz D. (2004)
- Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II. (PubMed id 15136722)1, 2 Mandal S.S.... Reinberg D. (2004)
- Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex. (PubMed id 12653964)1, 2 Kim D.-K.... Handa H. (2003)
|
External Searches for SUPT4H1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SUPT4H1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SUPT4H1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SUPT4H1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SUPT4H1 gene:
Search GeneIP for patents involving SUPT4H1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SUPT4H1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for SUPT4H1 | | OriGene shRNA RFP for SUPT4H1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUPT4H1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUPT4H1 | | | OriGene Protein Over-expression Lysate for SUPT4H1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SUPT4H1 | | OriGene 3'-UTR Clone for SUPT4H1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUPT4H1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUPT4H1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SUPT4H1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SUPT4H1 | | OriGene Custom Protein Services for SUPT4H1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SUPT4H1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SUPT4H1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUPT4H1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUPT4H1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUPT4H1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUPT4H1 |
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| | | | Search Tocris compounds for SUPT4H1 |
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 | | | SUPT4H1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT4H1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SUPT4H1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUPT4H1 |
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