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Aliases for SUPT3H Gene

Aliases for SUPT3H Gene

  • SPT3 Homolog, SAGA And STAGA Complex Component 2 3 5
  • SPT3-Like Protein 3 4
  • SPT3 3 4
  • Suppressor Of Ty 3 Homolog (S. Cerevisiae) 2
  • Suppressor Of Ty (S.Cerevisiae) 3 Homolog 2
  • Suppressor Of Ty 3 Homolog 3
  • SPT3L 3

External Ids for SUPT3H Gene

Previous GeneCards Identifiers for SUPT3H Gene

  • GC06M044799
  • GC06M044844
  • GC06M044843
  • GC06M044518

Summaries for SUPT3H Gene

GeneCards Summary for SUPT3H Gene

SUPT3H (SPT3 Homolog, SAGA And STAGA Complex Component) is a Protein Coding gene. Diseases associated with SUPT3H include blastic plasmacytoid dendritic cell. Among its related pathways are Validated targets of C-MYC transcriptional activation and Chromatin organization. GO annotations related to this gene include protein heterodimerization activity and histone acetyltransferase activity.

UniProtKB/Swiss-Prot for SUPT3H Gene

  • Probable transcriptional activator.

Gene Wiki entry for SUPT3H Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT3H Gene

Genomics for SUPT3H Gene

Regulatory Elements for SUPT3H Gene

Promoters for SUPT3H Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUPT3H on UCSC Golden Path with GeneCards custom track

Genomic Location for SUPT3H Gene

Chromosome:
6
Start:
44,807,499 bp from pter
End:
45,378,051 bp from pter
Size:
570,553 bases
Orientation:
Minus strand

Genomic View for SUPT3H Gene

Genes around SUPT3H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUPT3H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUPT3H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPT3H Gene

Proteins for SUPT3H Gene

  • Protein details for SUPT3H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75486-SUPT3_HUMAN
    Recommended name:
    Transcription initiation protein SPT3 homolog
    Protein Accession:
    O75486
    Secondary Accessions:
    • A6NKG9
    • B2R9Q5
    • O76066
    • Q5TAV9
    • Q86VN7

    Protein attributes for SUPT3H Gene

    Size:
    399 amino acids
    Molecular mass:
    44362 Da
    Quaternary structure:
    • Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Associates with TAFII31 and GCN5L2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22.

    Alternative splice isoforms for SUPT3H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUPT3H Gene

Proteomics data for SUPT3H Gene at MOPED

Post-translational modifications for SUPT3H Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SUPT3H Gene

Antibody Products

No data available for DME Specific Peptides for SUPT3H Gene

Domains & Families for SUPT3H Gene

Gene Families for SUPT3H Gene

Protein Domains for SUPT3H Gene

Suggested Antigen Peptide Sequences for SUPT3H Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75486

UniProtKB/Swiss-Prot:

SUPT3_HUMAN :
  • Belongs to the SPT3 family.
Family:
  • Belongs to the SPT3 family.
genes like me logo Genes that share domains with SUPT3H: view

Function for SUPT3H Gene

Molecular function for SUPT3H Gene

GENATLAS Biochemistry:
putative chromatin structure regulator,yeasqt spt3 (suppressor of Ty) homolog
UniProtKB/Swiss-Prot Function:
Probable transcriptional activator.
genes like me logo Genes that share phenotypes with SUPT3H: view

Animal Models for SUPT3H Gene

MGI Knock Outs for SUPT3H:

Animal Model Products

CRISPR Products

miRNA for SUPT3H Gene

miRTarBase miRNAs that target SUPT3H

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUPT3H Gene

Localization for SUPT3H Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUPT3H Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUPT3H Gene COMPARTMENTS Subcellular localization image for SUPT3H gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 1

Gene Ontology (GO) - Cellular Components for SUPT3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA --
GO:0033276 transcription factor TFTC complex IDA 10373431
genes like me logo Genes that share ontologies with SUPT3H: view

Pathways & Interactions for SUPT3H Gene

genes like me logo Genes that share pathways with SUPT3H: view

Pathways by source for SUPT3H Gene

1 KEGG pathway for SUPT3H Gene
1 GeneGo (Thomson Reuters) pathway for SUPT3H Gene

Gene Ontology (GO) - Biological Process for SUPT3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006355 regulation of transcription, DNA-templated NAS 9787080
GO:0043966 histone H3 acetylation IDA 11564863
GO:0045893 positive regulation of transcription, DNA-templated NAS 9787080
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with SUPT3H: view

No data available for SIGNOR curated interactions for SUPT3H Gene

Drugs & Compounds for SUPT3H Gene

No Compound Related Data Available

Transcripts for SUPT3H Gene

Unigene Clusters for SUPT3H Gene

Suppressor of Ty 3 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUPT3H Gene

No ASD Table

Relevant External Links for SUPT3H Gene

GeneLoc Exon Structure for
SUPT3H
ECgene alternative splicing isoforms for
SUPT3H

Expression for SUPT3H Gene

mRNA expression in normal human tissues for SUPT3H Gene

Protein differential expression in normal tissues from HIPED for SUPT3H Gene

This gene is overexpressed in Adrenal (25.9), Peripheral blood mononuclear cells (25.7), and CD8 Tcells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUPT3H Gene



SOURCE GeneReport for Unigene cluster for SUPT3H Gene Hs.368325

mRNA Expression by UniProt/SwissProt for SUPT3H Gene

O75486-SUPT3_HUMAN
Tissue specificity: Expressed in all tissues tested including pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
genes like me logo Genes that share expression patterns with SUPT3H: view

Protein tissue co-expression partners for SUPT3H Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SUPT3H Gene

Orthologs for SUPT3H Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUPT3H Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUPT3H 35
  • 92.5 (n)
  • 93.75 (a)
SUPT3H 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUPT3H 35
  • 93.33 (n)
  • 95.94 (a)
SUPT3H 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Supt3 35
  • 87.85 (n)
  • 90.65 (a)
Supt3 16
Supt3 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUPT3H 35
  • 99.76 (n)
  • 99.65 (a)
SUPT3H 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Supt3h 35
  • 88.06 (n)
  • 90.97 (a)
oppossum
(Monodelphis domestica)
Mammalia SUPT3H 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUPT3H 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUPT3H 35
  • 80.65 (n)
  • 87.38 (a)
SUPT3H 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUPT3H 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75923 35
supt3h 35
  • 72.85 (n)
  • 80.82 (a)
zebrafish
(Danio rerio)
Actinopterygii supt3h 35
  • 68.57 (n)
  • 75.24 (a)
wufd11f09 35
supt3h 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Spt3 36
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPT3 36
  • 26 (a)
OneToOne
SPT3 38
Species with no ortholog for SUPT3H:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUPT3H Gene

ENSEMBL:
Gene Tree for SUPT3H (if available)
TreeFam:
Gene Tree for SUPT3H (if available)

Paralogs for SUPT3H Gene

(1) SIMAP similar genes for SUPT3H Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SUPT3H: view

No data available for Paralogs for SUPT3H Gene

Variants for SUPT3H Gene

Sequence variations from dbSNP and Humsavar for SUPT3H Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs16872923 - 44,953,386(+) CCATG(G/T)CTTGC nc-transcript-variant, reference, missense
rs55641 -- 44,931,033(-) CCATC(G/T)TGGTT intron-variant
rs472672 -- 44,870,672(+) gctcc(A/G)gtcta intron-variant
rs472673 -- 44,902,540(+) gtcct(C/T)agaga intron-variant
rs488961 -- 44,867,324(+) TTTTC(A/G)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUPT3H Gene

Variant ID Type Subtype PubMed ID
esv272253 CNV Insertion 20981092
esv269908 CNV Insertion 20981092
esv1627992 CNV Insertion 17803354
esv2380124 CNV Deletion 18987734
esv2732018 CNV Deletion 23290073
esv2732019 CNV Deletion 23290073
esv2732020 CNV Deletion 23290073
dgv6845n71 CNV Loss 21882294
nsv5286 CNV Loss 18451855
dgv1946e1 CNV Complex 17122850
nsv885864 CNV Loss 21882294
esv2516025 CNV Deletion 19546169
nsv462938 CNV Loss 19166990
nsv470817 CNV Loss 18288195
esv2554212 CNV Deletion 19546169
essv2555 CNV CNV 17122850
esv2665320 CNV Deletion 23128226
nsv885865 CNV Loss 21882294
nsv5288 CNV Insertion 18451855
esv267477 CNV Insertion 20981092
esv2657532 CNV Deletion 23128226
nsv528130 CNV Loss 19592680
esv2678447 CNV Deletion 23128226
esv2668261 CNV Deletion 23128226
dgv1051e201 CNV Deletion 23290073
esv2732023 CNV Deletion 23290073
esv2732024 CNV Deletion 23290073
esv2732025 CNV Deletion 23290073
nsv830652 CNV Loss 17160897
esv2666379 CNV Deletion 23128226
esv2675500 CNV Deletion 23128226
esv267663 CNV Insertion 20981092
esv1738028 CNV Insertion 17803354
esv2476554 CNV Deletion 19546169
esv270815 CNV Insertion 20981092

Variation tolerance for SUPT3H Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUPT3H Gene

HapMap Linkage Disequilibrium report
SUPT3H
Human Gene Mutation Database (HGMD)
SUPT3H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUPT3H Gene

Disorders for SUPT3H Gene

MalaCards: The human disease database

(1) MalaCards diseases for SUPT3H Gene - From: GeneCards

Disorder Aliases PubMed IDs
blastic plasmacytoid dendritic cell
  • blastic nk-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SUPT3H

Genetic Association Database (GAD)
SUPT3H
Human Genome Epidemiology (HuGE) Navigator
SUPT3H
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUPT3H
genes like me logo Genes that share disorders with SUPT3H: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUPT3H Gene

Publications for SUPT3H Gene

  1. Histone-like TAFs within the PCAF histone acetylase complex. (PMID: 9674425) Ogryzko V.V. … Nakatani Y. (Cell 1998) 2 3 4 67
  2. STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation. (PMID: 17967894) Liu X. … Martinez E. (Mol. Cell. Biol. 2008) 3 23
  3. A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID. (PMID: 9726987) Martinez E. … Roeder R.G. (J. Biol. Chem. 1998) 2 3
  4. Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor Spt3 (SUPT3H). (PMID: 9787080) Yu J. … Olsen B.R. (Genomics 1998) 3 23
  5. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3

Products for SUPT3H Gene

Sources for SUPT3H Gene

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