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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUPT3H Gene

protein-coding   GIFtS: 62
GCID: GC06M044843

Suppressor Of Ty 3 Homolog (S. Cerevisiae)

(Previous name: suppressor of Ty (S.cerevisiae) 3 homolog)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppressor Of Ty 3 Homolog (S. Cerevisiae)1 2
SPT32 3
SPT3-Like Protein2 3
Suppressor Of Ty (S.Cerevisiae) 3 Homolog1
SPT3L2
Transcription Initiation Protein SPT3 Homolog2

External Ids:    HGNC: 114661   Entrez Gene: 84642   Ensembl: ENSG000001962847   OMIM: 6029475   UniProtKB: O754863   

Export aliases for SUPT3H gene to outside databases

Previous GC identifers: GC06M044799 GC06M044844 GC06M044904 GC06M044518


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SUPT3H Gene: 
SUPT3H (suppressor of Ty 3 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with SUPT3H include retinal degeneration, and retinitis, and among its related super-pathways are Transcription Ligand-Dependent Transcription of Retinoid-Target genes and Signal transduction Activin A signaling regulation. GO annotations related to this gene include histone acetyltransferase activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot: SUPT3_HUMAN, O75486
Function: Probable transcriptional activator

Gene Wiki entry for SUPT3H (Transcription initiation protein SPT3 homolog) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUPT3H gene promoter:
         AREB6   POU2F1   HNF-1   POU2F1a   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SUPT3H promoter sequence
   Search SABiosciences Chromatin IP Primers for SUPT3H

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUPT3H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1-p21.3   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1-p12.3

SUPT3H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUPT3H gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M044843:  view genomic region     (about GC identifiers)

Start:
44,777,054 bp from pter      End:
45,345,690 bp from pter
Size:
568,637 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SUPT3_HUMAN, O75486 (See protein sequence)
Recommended Name: Transcription initiation protein SPT3 homolog  
Size: 399 amino acids; 44362 Da
Subunit: Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta,
TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Associates with TAFII31 and GCN5L2.
Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150,
TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the STAGA transcription coactivator-HAT
complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3,
ENY2 and USP22
Subcellular location: Nucleus
Secondary accessions: A6NKG9 B2R9Q5 O76066 Q5TAV9 Q86VN7
Alternative splicing: 3 isoforms:  O75486-1   O75486-2   O75486-3   

Explore the universe of human proteins at neXtProt for SUPT3H: NX_O75486

Explore proteomics data for SUPT3H at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75486

  • SUPT3H Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SUPT3H Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001248752.1  NP_003590.1  NP_852001.1  

    ENSEMBL proteins: 
     ENSP00000436411   ENSP00000360515   ENSP00000360514   ENSP00000360513   ENSP00000306718  
     ENSP00000360516  

    Human Recombinant Protein Products for SUPT3H: 
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    Novus Biologicals SUPT3H Protein
    Novus Biologicals SUPT3H Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUPT3H 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0030914STAGA complex IDA11564863
    GO:0033276transcription factor TFTC complex IDA10373431

    SUPT3H for ontologies           About GeneDecksing



    SUPT3H Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SUPT3H 

    Assay Products for SUPT3H: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003195 TFIID-18
     IPR009072 Histone-fold

    Graphical View of Domain Structure for InterPro Entry O75486

    ProtoNet protein and cluster: O75486

    1 Blocks protein domain: IPB003195 Transcription initiation factor IID

    UniProtKB/Swiss-Prot: SUPT3_HUMAN, O75486
    Similarity: Belongs to the SPT3 family


    SUPT3H for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUPT3_HUMAN, O75486
    Function: Probable transcriptional activator

         Genatlas biochemistry entry for SUPT3H:
    putative chromatin structure regulator,yeasqt spt3 (suppressor of Ty) homolog

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA11564863
    GO:0004402contributes to histone acetyltransferase activity IDA11564863
    GO:0046982protein heterodimerization activity IEA--
         
    SUPT3H for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SUPT3H:
     Increased cell death in breast 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SUPT3H 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUPT3H

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUPT3H 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUPT3H 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUPT3H
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SUPT3H:
    hsa-miR-30c hsa-miR-30a hsa-miR-185* hsa-miR-1914* hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidSUPT3H 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of SUPT3H 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT3H


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SUPT3H About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00
    2Signal transduction Activin A signaling regulation
    Histone modification0.31
    3Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation
    4Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    5C-MYC pathway
    C-MYC pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for SUPT3H
        Histone modification
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for SUPT3H
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    2 BioSystems Pathways for SUPT3H
        C-MYC pathway
    Validated targets of C-MYC transcriptional activation


    1         Kegg Pathway  (Kegg details for SUPT3H):
        Transcriptional misregulation in cancer


    SUPT3H for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SUPT3H

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/167 Interacting proteins for SUPT3H (O754863 ENSP000003605154) via UniProtKB, MINT, STRING, and/or I2D (see all 167)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006352DNA-dependent transcription, initiation NAS--
    GO:0006355regulation of transcription, DNA-dependent NAS9787080
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9787080
    GO:0006366transcription from RNA polymerase II promoter IEA--
    GO:0016578histone deubiquitination IDA18206972

    SUPT3H for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUPT3H (SUPT3)

    Search CenterWatch for drugs/clinical trials and news about SUPT3H / SUPT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUPT3H gene (3 alternative transcripts): 
    NM_001261823.1  NM_003599.3  NM_181356.2  

    Unigene Cluster for SUPT3H:

    Suppressor of Ty 3 homolog (S. cerevisiae)
    Hs.368325  [show with all ESTs]
    Unigene Representative Sequence: NM_181356
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475057(uc003oxn.1 uc011dvw.2) ENST00000371460(uc003oxo.3 uc003oxp.3 uc011dvv.2)
    ENST00000371459 ENST00000371458 ENST00000459689 ENST00000306867 ENST00000371461

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SUPT3H:
    hsa-miR-30c hsa-miR-30a hsa-miR-185* hsa-miR-1914* hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidSUPT3H 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUPT3H
    Clone
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    OriGene clones in human, mouse for SUPT3H (see all 14)
    OriGene ORF clones in mouse, rat for SUPT3H
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SUPT3H (NM_181356)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUPT3H
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUPT3H
    Sirion Biotech Customized lentivirus for stable overexpression of SUPT3H 
                         Customized lentivirus expression plasmids for stable overexpression of SUPT3H 
    Primer
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    OriGene qPCR primer pairs and template standards for SUPT3H
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUPT3H
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUPT3H

    Additional mRNA sequence: 

    AF069734.1 AF073930.1 AF279781.1 AK092340.1 AK303838.1 AK313874.1 BC035816.1 BC050384.1 

    8 DOTS entries:

    DT.95322410  DT.97777300  DT.100779113  DT.121388677  DT.95322404  DT.100779115  DT.75115217  DT.95322423 

    24/57 AceView cDNA sequences (see all 57):

    NM_181356 BC050384 AF069734 BU682963 CA434351 CB150092 AI539126 CA416005 
    T98541 BG505836 CB122041 BI830710 AK092340 BF594328 BG720719 BM478348 
    BU189920 BI769939 BM927309 CB133874 AL523888 AA349248 BX504171 AI767005 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUPT3H expression in normal human tissues (normalized intensities)      SUPT3H embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SUPT3H Expression
    About this image


    SUPT3H expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             testis ; cells in seminiferus ducts   
             sperm   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             colon ; peripheral nerve/ganglion   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             lung ; pneumocytes   
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             esophagus ; squamous epithelial cells   

    See SUPT3H Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUPT3H

    SOURCE GeneReport for Unigene cluster: Hs.368325

    UniProtKB/Swiss-Prot: SUPT3_HUMAN, O75486
    Tissue specificity: Expressed in all tissues tested including pancreas, kidney, skeletal muscle, liver, lung,
    placenta, brain and heart

        SABiosciences Custom PCR Arrays for SUPT3H
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUPT3H
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT3H

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SUPT3H gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Supt35
    Supt3h1
    suppressor of Ty 3 homolog (S. cerevisiae)1, 5 87.85(n)1
    90.65(a)1
      17 (21.56 cM)5
    1091151  NM_178652.21  NP_848767.11 
     447771525 
    chicken
    (Gallus gallus)
    Aves SUPT3H1 suppressor of Ty 3 homolog (S. cerevisiae) 80.65(n)
    87.38(a)
      422053  NM_001031102.1  NP_001026273.1 
    lizard
    (Anolis carolinensis)
    Reptilia SUPT3H6
    suppressor of Ty 3 homolog (S. cerevisiae)
    63(a)
    1 ↔ 1
    1(139010024-139304201)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC759232 hypothetical protein MGC75923 77.19(n)    BC061367.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd11f092 Transcribed sequence with moderate similarity to protein more 78.42(n)    57055497 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spt31 CG3169-PA 44.36(n)
    35.43(a)
      41461  NM_141889.3  NP_650146.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPT3(YDR392W)4 Subunit of the SAGA and SAGA-like transcriptional regulatory more   --   4(1258696-1259709) 852001  NP_010680.1 


    ENSEMBL Gene Tree for SUPT3H (if available)
    TreeFam Gene Tree for SUPT3H (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUPT3H gene
    1 SIMAP similar gene for SUPT3H using alignment to 3 protein entries:     SUPT3_HUMAN (see all proteins):
    TAF13

    SUPT3H for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9849 SNPs in SUPT3H are shown (see all 9849)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901149341,2
    Cuntested145092616(+) CTAGAA/C/TGAATA 3 -- int10--------
    rs563296301,2
    C--44722692(+) ACACA-/CA/   
      CACACA
    TGCAC
    3 -- int11NA 2
    rs359855151,2
    C--44756139(+) GTCTC-/AAAAAA 3 -- int10--------
    rs1129833111,2
    C--44773163(+) GAATCATTATT/-
            
    ATTAT
    3 -- int11Minor allele frequency- -:0.50CSA 2
    rs1841882051,2
    --44794054(+) CTGTAA/CAACAA 3 -- ds50010--------
    rs1501260391,2
    C--44794067(+) CATGT-/AAAAAGT 3 -- ds50010--------
    rs1875311891,2
    --44794072(+) TAAAGC/TTTCAT 3 -- ds50010--------
    rs795802461,2
    F--44794156(+) CTATGA/TCATAT 3 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1409435311,2
    --44794264(+) TACATC/GGTTGA 3 -- ds50010--------
    rs1380894801,2
    --44794508(+) CTTCTA/GCATGG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SUPT3H (44777054 - 45027054 bp, first 250kb of SUPT3H)

    Structural Variations
         Database of Genomic Variants (DGV) 10/35 variations for SUPT3H (see all 35):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2476554CNV Deletion19546169
    esv2666379CNV Deletion23128226
    dgv1051e201CNV Deletion23290073
    esv2675500CNV Deletion23128226
    esv2732023CNV Deletion23290073
    esv2380124CNV Deletion18987734
    esv2732018CNV Deletion23290073
    esv2732020CNV Deletion23290073
    esv2516025CNV Deletion19546169
    esv2732024CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602947    OMIM disorders: --

    6 diseases for SUPT3H:    About MalaCards
    retinal degeneration    retinitis    acute lymphoblastic leukemia    lymphoblastic leukemia
    leukemia    breast cancer


    SUPT3H for disorders           About GeneDecksing

    Genetic Association Database (GAD): SUPT3H
    Human Genome Epidemiology (HuGE) Navigator: SUPT3H (7 documents)

    Export disorders for SUPT3H gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUPT3H gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with SUPT3H)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Histone-like TAFs within the PCAF histone acetylase complex. (PubMed id 9674425)1, 2, 3 Ogryzko V.V.... Nakatani Y. (1998)
    2. A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID. (PubMed id 9726987)1, 2, 3 Martinez E....Roeder R.G. (1998)
    3. Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor Spt3 (SUPT3H). (PubMed id 9787080)1, 2, 9 Yu J.... Olsen B.R. (1998)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Identification of 15 loci influencing height in a Kor ean population. (PubMed id 19893584)1, 4 Kim J.J....Lee J.K. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Assessment of transmission distortion on chromosome 6p in healthy individuals using tagSNPs. (PubMed id 19259136)1, 4 Santos P.S....Ziegler A. (2009)
    8. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (2008)
    9. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PubMed id 18206972)1, 2 Zhao Y.... Devys D. (2008)
    10. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8464 HGNC: 11466 AceView: SUPT3H Ensembl:ENSG00000196284 euGenes: HUgn8464
    ECgene: SUPT3H Kegg: 8464 H-InvDB: SUPT3H

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUPT3H Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SUPT3H Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUPT3H gene:
    Search GeneIP for patents involving SUPT3H

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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