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Aliases for SUPT3H Gene

Aliases for SUPT3H Gene

  • SPT3 Homolog, SAGA And STAGA Complex Component 2 3 5
  • SPT3-Like Protein 3 4
  • SPT3 3 4
  • Transcription Initiation Protein SPT3 Homolog 3
  • Suppressor Of Ty 3 Homolog (S. Cerevisiae) 2
  • Suppressor Of Ty (S.Cerevisiae) 3 Homolog 2
  • Suppressor Of Ty 3 Homolog 3
  • SPT3L 3

External Ids for SUPT3H Gene

Previous GeneCards Identifiers for SUPT3H Gene

  • GC06M044799
  • GC06M044844
  • GC06M044843
  • GC06M044904
  • GC06M044518

Summaries for SUPT3H Gene

GeneCards Summary for SUPT3H Gene

SUPT3H (SPT3 Homolog, SAGA And STAGA Complex Component) is a Protein Coding gene. Diseases associated with SUPT3H include Blastic Plasmacytoid Dendritic Cell. Among its related pathways are Chromatin organization and Transcriptional misregulation in cancer. GO annotations related to this gene include protein heterodimerization activity and histone acetyltransferase activity. An important paralog of this gene is ENSG00000283553.

UniProtKB/Swiss-Prot for SUPT3H Gene

  • Probable transcriptional activator.

Gene Wiki entry for SUPT3H Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT3H Gene

Genomics for SUPT3H Gene

Regulatory Elements for SUPT3H Gene

Enhancers for SUPT3H Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F045419 1.6 FANTOM5 Ensembl ENCODE 36.7 -45.9 -45881 9.3 SIN3A GLI4 ZNF2 GLIS2 ZNF202 ZNF263 MCM3 REST CBX8 ZNF610 SUPT3H ENSG00000271857 RUNX2 GC06P045490
GH06F045453 1.3 Ensembl ENCODE 12.3 -76.3 -76290 1.8 SIN3A FEZF1 ZNF2 GLIS2 GATA2 FOS KDM4B ZNF263 REST ZNF518A SUPT3H RUNX2 ENSG00000271857 GC06P045490
GH06F044665 1.4 FANTOM5 Ensembl ENCODE 8.7 +711.1 711102 3.7 CTCF SIN3A RAD21 ZKSCAN1 ZNF366 SCRT2 ZNF143 SMC3 NFE2 FOS SUPT3H GC06M044626 GC06M044627 LOC101929770
GH06F044800 1 Ensembl ENCODE 11.2 +577.5 577541 0.5 CTCF INSM2 ZNF140 FEZF1 RAD21 ZNF302 SCRT2 PRDM10 MAFK ZBTB20 AARS2 SUPT3H GC06P044730 NUDT19P4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SUPT3H on UCSC Golden Path with GeneCards custom track

Promoters for SUPT3H Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SUPT3H Gene

44,807,499 bp from pter
45,378,051 bp from pter
570,553 bases
Minus strand

Genomic View for SUPT3H Gene

Genes around SUPT3H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUPT3H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUPT3H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPT3H Gene

Proteins for SUPT3H Gene

  • Protein details for SUPT3H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription initiation protein SPT3 homolog
    Protein Accession:
    Secondary Accessions:
    • A6NKG9
    • B2R9Q5
    • O76066
    • Q5TAV9
    • Q86VN7

    Protein attributes for SUPT3H Gene

    399 amino acids
    Molecular mass:
    44362 Da
    Quaternary structure:
    • Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Associates with TAFII31 and GCN5L2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22.

    Alternative splice isoforms for SUPT3H Gene


neXtProt entry for SUPT3H Gene

Post-translational modifications for SUPT3H Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SUPT3H Gene

Domains & Families for SUPT3H Gene

Gene Families for SUPT3H Gene

Protein Domains for SUPT3H Gene

Suggested Antigen Peptide Sequences for SUPT3H Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPT3 family.
  • Belongs to the SPT3 family.
genes like me logo Genes that share domains with SUPT3H: view

Function for SUPT3H Gene

Molecular function for SUPT3H Gene

GENATLAS Biochemistry:
putative chromatin structure regulator,yeasqt spt3 (suppressor of Ty) homolog
UniProtKB/Swiss-Prot Function:
Probable transcriptional activator.

Gene Ontology (GO) - Molecular Function for SUPT3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with SUPT3H: view
genes like me logo Genes that share phenotypes with SUPT3H: view

Animal Models for SUPT3H Gene

MGI Knock Outs for SUPT3H:

Animal Model Products

miRNA for SUPT3H Gene

miRTarBase miRNAs that target SUPT3H

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUPT3H Gene

Localization for SUPT3H Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUPT3H Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUPT3H gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 1

Gene Ontology (GO) - Cellular Components for SUPT3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA --
GO:0005634 nucleus IEA,IDA 9726987
GO:0005654 nucleoplasm IDA --
GO:0005669 NOT transcription factor TFIID complex IBA --
GO:0030914 STAGA complex IDA 11564863
genes like me logo Genes that share ontologies with SUPT3H: view

Pathways & Interactions for SUPT3H Gene

genes like me logo Genes that share pathways with SUPT3H: view

Pathways by source for SUPT3H Gene

1 KEGG pathway for SUPT3H Gene
1 GeneGo (Thomson Reuters) pathway for SUPT3H Gene

Gene Ontology (GO) - Biological Process for SUPT3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 9787080
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9787080
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0016578 histone deubiquitination IDA 18206972
genes like me logo Genes that share ontologies with SUPT3H: view

No data available for SIGNOR curated interactions for SUPT3H Gene

Transcripts for SUPT3H Gene

Unigene Clusters for SUPT3H Gene

Suppressor of Ty 3 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUPT3H Gene

No ASD Table

Relevant External Links for SUPT3H Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SUPT3H Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SUPT3H Gene

Protein differential expression in normal tissues from HIPED for SUPT3H Gene

This gene is overexpressed in Adrenal (25.9), Peripheral blood mononuclear cells (25.7), and CD8 Tcells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUPT3H Gene

Protein tissue co-expression partners for SUPT3H Gene

NURSA nuclear receptor signaling pathways regulating expression of SUPT3H Gene:


SOURCE GeneReport for Unigene cluster for SUPT3H Gene:


mRNA Expression by UniProt/SwissProt for SUPT3H Gene:

Tissue specificity: Expressed in all tissues tested including pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
genes like me logo Genes that share expression patterns with SUPT3H: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SUPT3H Gene

Orthologs for SUPT3H Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUPT3H Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SUPT3H 34 35
  • 99.76 (n)
(Ornithorhynchus anatinus)
Mammalia SUPT3H 35
  • 97 (a)
(Canis familiaris)
Mammalia SUPT3H 34 35
  • 93.33 (n)
(Bos Taurus)
Mammalia SUPT3H 34 35
  • 92.5 (n)
(Rattus norvegicus)
Mammalia Supt3h 34
  • 88.06 (n)
(Mus musculus)
Mammalia Supt3 34 16 35
  • 87.85 (n)
(Monodelphis domestica)
Mammalia SUPT3H 35
  • 68 (a)
(Gallus gallus)
Aves SUPT3H 34 35
  • 80.65 (n)
(Anolis carolinensis)
Reptilia SUPT3H 35
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia supt3h 34
  • 72.85 (n)
MGC75923 34
(Danio rerio)
Actinopterygii supt3h 34 35
  • 68.57 (n)
wufd11f09 34
fruit fly
(Drosophila melanogaster)
Insecta Spt3 35
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPT3 35 37
  • 26 (a)
Species where no ortholog for SUPT3H was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUPT3H Gene

Gene Tree for SUPT3H (if available)
Gene Tree for SUPT3H (if available)

Paralogs for SUPT3H Gene

Paralogs for SUPT3H Gene

(1) SIMAP similar genes for SUPT3H Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SUPT3H: view

Variants for SUPT3H Gene

Sequence variations from dbSNP and Humsavar for SUPT3H Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10080909 -- 45,143,545(+) acagc(A/C)aaagt intron-variant
rs10223435 -- 45,090,537(+) TTTTT(A/T)TCCAC intron-variant
rs1023089 -- 45,044,609(+) TTATG(A/G)TAAAA intron-variant
rs1023090 -- 45,044,644(+) AAAAA(C/T)AGCTT intron-variant
rs1023091 -- 45,007,285(+) CTACT(C/T)AACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUPT3H Gene

Variant ID Type Subtype PubMed ID
nsv830652 CNV loss 17160897
nsv603008 CNV loss 21841781
nsv603007 CNV loss 21841781
nsv5288 CNV insertion 18451855
nsv5286 CNV deletion 18451855
nsv528130 CNV loss 19592680
nsv470817 CNV loss 18288195
nsv462938 CNV loss 19166990
nsv1117618 CNV deletion 24896259
nsv1109773 CNV deletion 24896259
nsv1033815 CNV gain 25217958
nsv1032906 CNV loss 25217958
nsv1028068 CNV loss 25217958
nsv1024370 CNV loss 25217958
esv3890844 CNV loss 25118596
esv3608861 CNV loss 21293372
esv3608860 CNV loss 21293372
esv3608858 CNV loss 21293372
esv3608857 CNV loss 21293372
esv3608855 CNV loss 21293372
esv3608854 CNV loss 21293372
esv3608853 CNV loss 21293372
esv3608851 CNV gain 21293372
esv3608847 CNV gain 21293372
esv3608845 CNV loss 21293372
esv3608843 CNV loss 21293372
esv3608841 CNV loss 21293372
esv3571036 CNV loss 25503493
esv3571035 CNV loss 25503493
esv3571034 CNV loss 25503493
esv3567735 CNV deletion 23714750
esv3409563 CNV insertion 20981092
esv3401379 CNV insertion 20981092
esv3385505 CNV insertion 20981092
esv3384552 CNV insertion 20981092
esv3342218 CNV insertion 20981092
esv3340653 CNV insertion 20981092
esv3307979 CNV mobile element insertion 20981092
esv3306539 CNV mobile element insertion 20981092
esv3305631 CNV mobile element insertion 20981092
esv2763550 CNV loss 21179565
esv2762589 CNV loss 21179565
esv2759423 CNV gain+loss 17122850
esv2732025 CNV deletion 23290073
esv2732024 CNV deletion 23290073
esv2732023 CNV deletion 23290073
esv2732020 CNV deletion 23290073
esv2732019 CNV deletion 23290073
esv2732018 CNV deletion 23290073
esv2678447 CNV deletion 23128226
esv2675500 CNV deletion 23128226
esv2668261 CNV deletion 23128226
esv2666379 CNV deletion 23128226
esv2665320 CNV deletion 23128226
esv2657532 CNV deletion 23128226
esv2554212 CNV deletion 19546169
esv2516025 CNV deletion 19546169
esv2476554 CNV deletion 19546169
esv2380124 CNV deletion 18987734
esv1738028 CNV insertion 17803354
esv1627992 CNV insertion 17803354
dgv5958n100 CNV loss 25217958
dgv1764e212 CNV loss 25503493
dgv1180e214 CNV loss 21293372
dgv1179e214 CNV loss 21293372
dgv1004e201 CNV deletion 23290073

Variation tolerance for SUPT3H Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUPT3H Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUPT3H Gene

Disorders for SUPT3H Gene

MalaCards: The human disease database

(1) MalaCards diseases for SUPT3H Gene - From: GeneCards

Disorder Aliases PubMed IDs
blastic plasmacytoid dendritic cell
  • blastic nk-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SUPT3H

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SUPT3H: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUPT3H Gene

Publications for SUPT3H Gene

  1. Histone-like TAFs within the PCAF histone acetylase complex. (PMID: 9674425) Ogryzko V.V. … Nakatani Y. (Cell 1998) 2 3 4 64
  2. A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID. (PMID: 9726987) Martinez E. … Roeder R.G. (J. Biol. Chem. 1998) 2 3 4 64
  3. Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor Spt3 (SUPT3H). (PMID: 9787080) Yu J. … Olsen B.R. (Genomics 1998) 3 4 22 64
  4. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim J.J. … Lee J.K. (J. Hum. Genet. 2010) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for SUPT3H Gene

Sources for SUPT3H Gene

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