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Aliases for SUPT20H Gene

Aliases for SUPT20H Gene

  • SPT20 Homolog, SAGA Complex Component 2 3 5
  • Transcription Factor (P38 Interacting Protein) 2 3
  • Family With Sequence Similarity 48, Member A 2 3
  • C13orf19 3 4
  • FAM48A 3 4
  • P38IP 3 4
  • Suppressor Of Ty 20 Homolog (S. Cerevisiae) 2
  • Chromosome 13 Open Reading Frame 19 2
  • Suppressor Of Ty 20 Homolog 3
  • P38 Interacting Protein 2
  • Tumor Rejection Antigen 3
  • P38-Interacting Protein 4
  • Protein FAM48A 3
  • FP757 3
  • SPT20 3
  • C13 3

External Ids for SUPT20H Gene

Previous HGNC Symbols for SUPT20H Gene

  • C13orf19
  • FAM48A

Previous GeneCards Identifiers for SUPT20H Gene

  • GC13M037584

Summaries for SUPT20H Gene

GeneCards Summary for SUPT20H Gene

SUPT20H (SPT20 Homolog, SAGA Complex Component) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include transcription cofactor activity.

UniProtKB/Swiss-Prot for SUPT20H Gene

  • Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.

Gene Wiki entry for SUPT20H Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT20H Gene

Genomics for SUPT20H Gene

Regulatory Elements for SUPT20H Gene

Promoters for SUPT20H Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUPT20H on UCSC Golden Path with GeneCards custom track

Genomic Location for SUPT20H Gene

Chromosome:
13
Start:
37,009,312 bp from pter
End:
37,059,713 bp from pter
Size:
50,402 bases
Orientation:
Minus strand

Genomic View for SUPT20H Gene

Genes around SUPT20H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUPT20H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUPT20H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPT20H Gene

Proteins for SUPT20H Gene

  • Protein details for SUPT20H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEM7-SP20H_HUMAN
    Recommended name:
    Transcription factor SPT20 homolog
    Protein Accession:
    Q8NEM7
    Secondary Accessions:
    • E7ER46
    • Q71RF3
    • Q9Y6A6

    Protein attributes for SUPT20H Gene

    Size:
    779 amino acids
    Molecular mass:
    85789 Da
    Quaternary structure:
    • Interacts with MAPK14. Interacts with ATG9A.
    SequenceCaution:
    • Sequence=AAQ15220.1; Type=Frameshift; Positions=562; Evidence={ECO:0000305}; Sequence=AAQ15220.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for SUPT20H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUPT20H Gene

Proteomics data for SUPT20H Gene at MOPED

Post-translational modifications for SUPT20H Gene

  • Ubiquitination at Lys 155, Lys 269, Lys 351, and Lys 418
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SUPT20H Gene

Domains & Families for SUPT20H Gene

Gene Families for SUPT20H Gene

Protein Domains for SUPT20H Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SUPT20H Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEM7

UniProtKB/Swiss-Prot:

SP20H_HUMAN :
  • Belongs to the SPT20 family.
Family:
  • Belongs to the SPT20 family.
genes like me logo Genes that share domains with SUPT20H: view

Function for SUPT20H Gene

Molecular function for SUPT20H Gene

UniProtKB/Swiss-Prot Function:
Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.
genes like me logo Genes that share phenotypes with SUPT20H: view

Animal Model Products

CRISPR Products

miRNA for SUPT20H Gene

miRTarBase miRNAs that target SUPT20H

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUPT20H Gene

Localization for SUPT20H Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUPT20H Gene

Gene Ontology (GO) - Cellular Components for SUPT20H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IEA --
genes like me logo Genes that share ontologies with SUPT20H: view

No data available for Subcellular locations from COMPARTMENTS for SUPT20H Gene

Pathways & Interactions for SUPT20H Gene

genes like me logo Genes that share pathways with SUPT20H: view

Pathways by source for SUPT20H Gene

Gene Ontology (GO) - Biological Process for SUPT20H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with SUPT20H: view

No data available for SIGNOR curated interactions for SUPT20H Gene

Drugs & Compounds for SUPT20H Gene

No Compound Related Data Available

Transcripts for SUPT20H Gene

Unigene Clusters for SUPT20H Gene

Suppressor of Ty 20 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUPT20H Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6: -
SP7:

Relevant External Links for SUPT20H Gene

GeneLoc Exon Structure for
SUPT20H
ECgene alternative splicing isoforms for
SUPT20H

Expression for SUPT20H Gene

mRNA expression in normal human tissues for SUPT20H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SUPT20H Gene

This gene is overexpressed in CD4 Tcells (19.1), CD8 Tcells (17.7), Placenta (14.5), Monocytes (8.3), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUPT20H Gene



SOURCE GeneReport for Unigene cluster for SUPT20H Gene Hs.435815

mRNA Expression by UniProt/SwissProt for SUPT20H Gene

Q8NEM7-SP20H_HUMAN
Tissue specificity: Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues.
genes like me logo Genes that share expression patterns with SUPT20H: view

Protein tissue co-expression partners for SUPT20H Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SUPT20H Gene

Orthologs for SUPT20H Gene

This gene was present in the common ancestor of animals.

Orthologs for SUPT20H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM48A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM48A 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUPT20H 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Supt20 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUPT20H 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUPT20H 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM48A 35
  • 81.53 (n)
  • 84.5 (a)
SUPT20H 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUPT20H 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia supt20h 35
  • 74.94 (n)
  • 75.82 (a)
zebrafish
(Danio rerio)
Actinopterygii supt20 36
  • 61 (a)
OneToOne
Dr.19925 35
LOC568453 35
  • 65.8 (n)
  • 71.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spt20 36
  • 9 (a)
OneToOne
Species with no ortholog for SUPT20H:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUPT20H Gene

ENSEMBL:
Gene Tree for SUPT20H (if available)
TreeFam:
Gene Tree for SUPT20H (if available)

Paralogs for SUPT20H Gene

(3) SIMAP similar genes for SUPT20H Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SUPT20H Gene

genes like me logo Genes that share paralogs with SUPT20H: view

No data available for Paralogs for SUPT20H Gene

Variants for SUPT20H Gene

Sequence variations from dbSNP and Humsavar for SUPT20H Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs7324275 - 37,040,629(+) TTTCA(C/T)GTTAC nc-transcript-variant, reference, missense
VAR_055799 -
rs1199957 -- 37,043,508(+) AACTA(C/T)AGGGA intron-variant
rs1199961 -- 37,060,014(-) TTGGA(C/T)TAGTA upstream-variant-2KB
rs1199962 -- 37,059,687(+) TCCGA(C/T)TGGCA upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for SUPT20H Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUPT20H Gene

HapMap Linkage Disequilibrium report
SUPT20H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SUPT20H Gene

Disorders for SUPT20H Gene

Relevant External Links for SUPT20H

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUPT20H

No disorders were found for SUPT20H Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUPT20H Gene

Publications for SUPT20H Gene

  1. Functional analyses of C13orf19/P38IP in prostate cell lines. (PMID: 16685401) Kunze D. … Schmidt U. (Oncol. Rep. 2006) 2 3 23 67
  2. The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. (PMID: 19114550) Nagy Z. … Tora L. (Mol. Cell. Biol. 2009) 2 3
  3. Quantification of C13orf19/P38IP mRNA expression by quantitative real-time PCR in patients with urological malignancies. (PMID: 15978328) Schmidt U. … Wirth M.P. (Cancer Lett. 2005) 3 23
  4. Novel transcription factors in human CD34 antigen-positive hematopoietic cells. (PMID: 12070015) Gomes I. … Westbrook C.A. (Blood 2002) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SUPT20H Gene

Sources for SUPT20H Gene

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