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Aliases for SUPT20H Gene

Aliases for SUPT20H Gene

  • Suppressor Of Ty 20 Homolog (S. Cerevisiae) 2 3
  • C13orf19 3 4 6
  • FAM48A 3 4 6
  • P38IP 3 4 6
  • Transcription Factor (P38 Interacting Protein) 2 3
  • Family With Sequence Similarity 48, Member A 2 3
  • Chromosome 13 Open Reading Frame 19 2
  • Transcription Factor SPT20 Homolog 3
  • P38 Interacting Protein 2
  • Tumor Rejection Antigen 3
  • P38-Interacting Protein 4
  • Protein FAM48A 3
  • FP757 3
  • SPT20 3
  • C13 3

External Ids for SUPT20H Gene

Previous HGNC Symbols for SUPT20H Gene

  • C13orf19
  • FAM48A

Previous GeneCards Identifiers for SUPT20H Gene

  • GC13M037584

Summaries for SUPT20H Gene

GeneCards Summary for SUPT20H Gene

SUPT20H (Suppressor Of Ty 20 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include transcription cofactor activity.

UniProtKB/Swiss-Prot for SUPT20H Gene

  • Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.

Gene Wiki entry for SUPT20H Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT20H Gene

Genomics for SUPT20H Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUPT20H Gene

Start:
37,009,312 bp from pter
End:
37,059,713 bp from pter
Size:
50,402 bases
Orientation:
Minus strand

Genomic View for SUPT20H Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUPT20H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPT20H Gene

No data available for Regulatory Elements for SUPT20H Gene

Proteins for SUPT20H Gene

  • Protein details for SUPT20H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEM7-SP20H_HUMAN
    Recommended name:
    Transcription factor SPT20 homolog
    Protein Accession:
    Q8NEM7
    Secondary Accessions:
    • E7ER46
    • Q71RF3
    • Q9Y6A6

    Protein attributes for SUPT20H Gene

    Size:
    779 amino acids
    Molecular mass:
    85789 Da
    Quaternary structure:
    • Interacts with MAPK14. Interacts with ATG9A.
    SequenceCaution:
    • Sequence=AAQ15220.1; Type=Frameshift; Positions=562; Evidence={ECO:0000305}; Sequence=AAQ15220.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for SUPT20H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUPT20H Gene

Proteomics data for SUPT20H Gene at MOPED

Post-translational modifications for SUPT20H Gene

  • Ubiquitination at Lys155, Lys269, Lys351, and Lys418
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SUPT20H Gene

Domains for SUPT20H Gene

Protein Domains for SUPT20H Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NEM7

UniProtKB/Swiss-Prot:

SP20H_HUMAN :
  • Q8NEM7
Family:
  • Belongs to the SPT20 family.
genes like me logo Genes that share domains with SUPT20H: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SUPT20H Gene

Function for SUPT20H Gene

Molecular function for SUPT20H Gene

UniProtKB/Swiss-Prot Function: Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.

Gene Ontology (GO) - Molecular Function for SUPT20H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IEA --
GO:0005515 protein binding IPI 16751104
genes like me logo Genes that share ontologies with SUPT20H: view
genes like me logo Genes that share phenotypes with SUPT20H: view

Animal Model Products

CRISPR Products

miRNA for SUPT20H Gene

miRTarBase miRNAs that target SUPT20H

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SUPT20H Gene

Localization for SUPT20H Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUPT20H Gene

Gene Ontology (GO) - Cellular Components for SUPT20H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IEA --
GO:0005730 nucleolus IDA --
GO:0070461 SAGA-type complex IDA 18838386
genes like me logo Genes that share ontologies with SUPT20H: view

No data available for Subcellular locations from COMPARTMENTS for SUPT20H Gene

Pathways for SUPT20H Gene

genes like me logo Genes that share pathways with SUPT20H: view

Pathways by source for SUPT20H Gene

Gene Ontology (GO) - Biological Process for SUPT20H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006914 autophagy IEA --
GO:0007369 gastrulation IEA --
GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IEA --
GO:2001141 regulation of RNA biosynthetic process --
genes like me logo Genes that share ontologies with SUPT20H: view

Transcripts for SUPT20H Gene

Unigene Clusters for SUPT20H Gene

Suppressor of Ty 20 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUPT20H

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SUPT20H
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUPT20H Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6: -
SP7:

Relevant External Links for SUPT20H Gene

GeneLoc Exon Structure for
SUPT20H
ECgene alternative splicing isoforms for
SUPT20H

Expression for SUPT20H Gene

mRNA expression in normal human tissues for SUPT20H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUPT20H Gene

SOURCE GeneReport for Unigene cluster for SUPT20H Gene Hs.435815

mRNA Expression by UniProt/SwissProt for SUPT20H Gene

Q8NEM7-SP20H_HUMAN
Tissue specificity: Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues.
genes like me logo Genes that share expressions with SUPT20H: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SUPT20H Gene

Orthologs for SUPT20H Gene

This gene was present in the common ancestor of animals.

Orthologs for SUPT20H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM48A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM48A 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUPT20H 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Supt20 16
Supt20 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUPT20H 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUPT20H 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM48A 35
  • 81.53 (n)
  • 84.5 (a)
SUPT20H 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUPT20H 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia supt20h 35
  • 74.94 (n)
  • 75.82 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.19925 35
LOC568453 35
  • 65.8 (n)
  • 71.62 (a)
supt20 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Spt20 36
  • 9 (a)
OneToOne
Species with no ortholog for SUPT20H:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUPT20H Gene

ENSEMBL:
Gene Tree for SUPT20H (if available)
TreeFam:
Gene Tree for SUPT20H (if available)

Paralogs for SUPT20H Gene

Selected SIMAP similar genes for SUPT20H Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SUPT20H Gene

genes like me logo Genes that share paralogs with SUPT20H: view

No data available for Paralogs for SUPT20H Gene

Variants for SUPT20H Gene

Sequence variations from dbSNP and Humsavar for SUPT20H Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs727070 -- 37,033,828(-) AAAAG(C/T)GCAAT intron-variant
rs1199957 -- 37,043,508(+) AACTA(C/T)AGGGA intron-variant
rs1199961 -- 37,060,014(-) TTGGA(C/T)TAGTA upstream-variant-2KB
rs1199962 -- 37,059,687(+) TCCGA(C/T)TGGCA upstream-variant-2KB
rs1199963 -- 37,059,388(-) ACTCC(A/C)GGTGG intron-variant, utr-variant-5-prime

Relevant External Links for SUPT20H Gene

HapMap Linkage Disequilibrium report
SUPT20H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SUPT20H Gene

Disorders for SUPT20H Gene

No disorders were found for SUPT20H Gene.

No data available for UniProtKB/Swiss-Prot for SUPT20H Gene

Publications for SUPT20H Gene

  1. Functional analyses of C13orf19/P38IP in prostate cell lines. (PMID: 16685401) Kunze D. … Schmidt U. (Oncol. Rep. 2006) 2 3 23
  2. Identification of a novel gene on chromosome 13 between BRCA2 and Rb1. (PMID: 11340631) Schmidt U. … Wirth M.P. (Prostate 2001) 3 4
  3. Novel transcription factors in human CD34 antigen-positive hematopoietic cells. (PMID: 12070015) Gomes I. … Westbrook C.A. (Blood 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4

Products for SUPT20H Gene

Sources for SUPT20H Gene

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