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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUPT16H Gene

protein-coding   GIFtS: 55
GCID: GC14M021819

suppressor of Ty 16 homolog (S. cerevisiae)

(Previous name: suppressor of Ty (S.cerevisiae) 16 homolog )
 Explore 2 diseases affiliated with
SUPT16H via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SUPT16H    

Aliases
for SUPT16H gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Suppressor Of Ty 16 Homolog (S. Cerevisiae)1 2     FACT1
FACTP1401 2 3     FLJ108571
CDC681 2     FLJ140101
SPT16/CDC681 2     Suppressor Of Ty (S.Cerevisiae) 16 Homolog1
Chromatin-Specific Transcription Elongation Factor 140 KDa Subunit2 3     Facilitates Chromatin Remodeling 140 KDa Subunit2
Facilitates Chromatin Transcription Complex Subunit SPT162 3     FACT Complex Subunit SPT162
FACT 140 KDa Subunit2 3     FACT1403
HSPT161     FACTp1403

External Ids:    HGNC: 114651   Entrez Gene: 111982   Ensembl: ENSG000000922017   OMIM: 6050125   UniProtKB: Q9Y5B93   

Export aliases for SUPT16H gene to outside databases

Previous GC identifers: GC00U990361 GC14M015606 GC14M019809 GC14M020889 GC14M001939


Summaries
for SUPT16H gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SUPT16H:
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and
RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that
accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts
specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of
an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. (provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: SP16H_HUMAN, Q9Y5B9
Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT
complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and
DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and
restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the
dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the
nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation
of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Also involved in vitamin D-coupled
transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by
vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By
similarity)

Gene Wiki entry for SUPT16H


Genomic Views
for SUPT16H gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUPT16H gene promoter:
         E2F-3a   TBP   E2F   E2F-1   TFIID   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SUPT16H promoter sequence
   Search SABiosciences Chromatin IP Primers for SUPT16H

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUPT16H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

SUPT16H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUPT16H gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021819:  view genomic region     (about GC identifiers)

Start:
 21,819,631 bp from pter      End:
 21,852,425 bp from pter
Size:
 32,795 bases      Orientation:
 minus strand

Proteins
for SUPT16H gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SP16H_HUMAN, Q9Y5B9 (See protein sequence)
Recommended Name: FACT complex subunit SPT16  
Size: 1047 amino acids; 119914 Da
Subunit: Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H. Also component of a CK2-SPT16-SSRP1
complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B. Component of
the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A,
BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Interacts with NEK9. Binds to histone H2A-H2B. Interacts with GTF2E2
Subcellular location: Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively
transcribed loci
Caution: Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting
that it may lack peptidase activity
Sequence caution: Sequence=AAH64561.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence; Sequence=AAH73849.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: Q6GMT8 Q6P2F1 Q6PJM1 Q9NRX0

Explore the universe of human proteins at neXtProt for SUPT16H: NX_Q9Y5B9

Post-translational modifications:

  • ADP-ribosylated. ADP-ribosylation by PARP1 is induced by genotoxic stress and correlates with dissociation of FACT from
    • chromatin1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5B9

    • SUPT16H Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_009123.1  
    ENSEMBL proteins: 
     ENSP00000216297   ENSP00000452259   ENSP00000451517   ENSP00000450910  
    Reactome Protein details: Q9Y5B9
    Human Recombinant Protein Products: 
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    OriGene Custom Protein Services for SUPT16H 
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    Novus Biologicals SUPT16H Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SUPT16H

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome IEA--


    SUPT16H for ontologies           About GeneDecksing



    SUPT16H Antibody Products: 
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    Abcam antibodies for SUPT16H 
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    Uscn ELISAs and CLIAs for SUPT16H

    Protein Domains /
    Families
    for SUPT16H gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SUPT16H for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013719 DUF1747
     IPR000994 Pept_M24_structural-domain
     IPR013953 FACT_Spt16p

    Graphical View of Domain Structure for InterPro Entry Q9Y5B9

    ProtoNet protein and cluster: Q9Y5B9

    2 Blocks protein families:
    IPB013719 Domain of unknown function DUF1747
    IPB013953 FACT complex subunit Spt16p/Cdc68p


    UniProtKB/Swiss-Prot: SP16H_HUMAN, Q9Y5B9
    Domain: The Glu-rich acidic region in C-terminus is essential for FACT activity
    Similarity: Belongs to the peptidase M24 family. SPT16 subfamily


    Function
    for SUPT16H gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SP16H_HUMAN, Q9Y5B9
    Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT
    complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and
    DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and
    restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the
    dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the
    nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation
    of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Also involved in vitamin D-coupled
    transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by
    vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By
    similarity)

    miRNA
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    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate SUPT16H (see all 46):
    hsa-miR-3678-3p hsa-miR-15a hsa-miR-877* hsa-miR-1273d hsa-miR-424 hsa-miR-654-5p hsa-miR-133a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SUPT16H 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUPT16H (see all 4)
    OriGene shRNA RFP: SUPT16H
    OriGene siRNA: SUPT16H
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUPT16H

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SUPT16H

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUPT16H (see all 2)
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    Cell Line
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    Search LifeMap BioReagents cell lines for SUPT16H

    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding ----


    SUPT16H for ontologies           About GeneDecksing



    Pathways & Interactions
    for SUPT16H gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of RNA Pol II elongation complex
    8/13 pathways (see all 13)
    		RNA Polymerase II Transcription Elongation1.00
    		Pausing and recovery of HIV-1 elongation0.74
    		Formation of HIV-1 elongation complex in the absence of HIV-1 Tat1.00
    		Elongation arrest and recovery0.74
    		Formation of RNA Pol II elongation complex 1.00
    		RNA Polymerase II Pre-transcription Events0.72
    		Formation of HIV-1 elongation complex containing HIV-1 Tat0.98
    		Tat-mediated HIV-1 elongation arrest and recovery 0.71
    2Late Phase of HIV Life Cycle
    		Late Phase of HIV Life Cycle1.00
    		HIV Life Cycle0.90
    3Transcription
    		Transcription1.00
    		RNA Polymerase II Transcription0.69
    4HIV Infection
    		HIV Infection1.00
    5Disease
    		Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SUPT16H
        Chromatin Regulation / Acetylation

    5/20        Reactome Pathways for SUPT16H (see all 20)
        Formation of RNA Pol II elongation complex
    Pausing and recovery of Tat-mediated HIV-1 elongation
    Tat-mediated HIV-1 elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Late Phase of HIV Life Cycle



    SUPT16H for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SUPT16H

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/785 Interacting proteins for SUPT16H (Q9Y5B92, 3 ENSP000002162974) via UniProtKB, MINT, STRING, and/or I2D (see all 785)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=8 
    HIST1H4BP628053I2D: score=8 
    HIST1H4CP628053I2D: score=8 
    HIST1H4DP628053I2D: score=8 
    HIST1H4EP628053I2D: score=8 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006281DNA repair IEA--
    GO:0006337nucleosome disassembly TAS10421373
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--


    SUPT16H for ontologies           About GeneDecksing



    Drugs & Compounds
    for SUPT16H gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUPT16H
    Search CenterWatch for drugs/clinical trials and news about SUPT16H / SP16H 

    Transcripts
    for SUPT16H gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SUPT16H gene: 
    NM_007192.3  

    Unigene Cluster for SUPT16H:

    Suppressor of Ty 16 homolog (S. cerevisiae)
    Hs.213724  [show with all ESTs]
    Unigene Representative Sequence: NM_007192
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216297(uc001wao.2) ENST00000557394(uc001wan.2) ENST00000552829
    ENST00000556309 ENST00000556217 ENST00000557652 ENST00000555752 ENST00000555943(uc001waq.2)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUPT16H
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate SUPT16H (see all 46):
    hsa-miR-3678-3p hsa-miR-15a hsa-miR-877* hsa-miR-1273d hsa-miR-424 hsa-miR-654-5p hsa-miR-133a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SUPT16H 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUPT16H (see all 4)
    OriGene shRNA RFP: SUPT16H
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUPT16H
    Clone
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    GenScript: all cDNA clones in your preferred vector: SUPT16H (NM_007192)
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    Primer
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    Additional cDNA sequence: 

    AF164924.1 AK001719.1 AK024072.1 AK091676.1 BC000565.2 BC012582.1 BC014046.2 BC064561.1 
    BC073849.1 BC111402.1 

    21 DOTS entries:

    DT.448845  DT.100817530  DT.92452862  DT.100817531  DT.97788439  DT.100756355  DT.99976736  DT.120756997 
    DT.95186345  DT.100774288  DT.120756709  DT.121188430  DT.95101887  DT.120756769  DT.120756811  DT.120756849 
    DT.120756970  DT.95186358  DT.120757016  DT.75132147  DT.97856616 

    24/357 AceView cDNA sequences (see all 357):

    CR616669 BU156436 BU156107 BQ775979 BP358828 AA985210 CR612151 BC000565 
    BG286896 BQ944241 BQ184243 BC073849 CR594514 NM_007192 CB121141 BQ049605 
    BX384771 BM766873 AA911237 AA720952 BC014046 AI357284 BM743530 AA130822 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SUPT16H (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:              -           -     -     -                                                                                                                     
    SP2:                                                                                                                                                            
    SP3:                                      -                                                                                                                     
    SP4:              -                       -                                                                                                                     
    SP5:              -                                                                                                                                             

    ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for SUPT16H

    Expression
    for SUPT16H gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUPT16H expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTTGGGCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SUPT16H expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Reproductive SystemEarly GonadTestis Somatic CellsTestis
    BoneAutopod Long BoneBone
    Gut TubeMidgutGut Tube
    KidneyMetanephrosKidney
    LiverLiver LobuleLiver
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SUPT16H Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUPT16H

    SOURCE GeneReport for Unigene cluster: Hs.213724

    UniProtKB/Swiss-Prot: SP16H_HUMAN, Q9Y5B9
    Tissue specificity: Ubiquitous

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    Orthologs
    for SUPT16H gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUPT16H gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Supt165
    Supt16h1    		 suppressor of Ty 16 homolog (S. cerevisiae)1, 5 90.83(n)1
    98.76(a)1    		   14 (26.83 cM)5
    1147411  NM_033618.31  NP_291096.21 
     521604195 
    lizard
    (Anolis carolinensis)    		 Reptilia SUPT16H6
    		 --
    		 89(a)
    		 1 ↔ 1
    		 GL343466.1(382700-401595)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.79832 Xenopus laevis mRNA for DUF140, complete cds 79.71(n)    AB004794.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii supt16h1 suppressor of Ty 16 homolog 74.89(n)
    85.03(a)    		   562348  NM_001097584.1  NP_001091053.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta dre41 CG1828-PA 60.59(n)
    61.1(a)    		   38248  NM_057262.3  NP_476610.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea F55A3.31 Protein F55A3.3 54.19(n)
    48.97(a)    		   172984  NM_060420.3  NP_492821.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SPT16(YGL207W)4
    SPT161    		 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases less4
    Spt16p1    		 46.81(n)1
    37.56(a)1    		   7(98969-102076)4
    8526651, 4  NP_011308.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SPT161 FACT complex subunit SPT16 48.5(n)
    37.65(a)    		   826665  NM_117139.2  NP_192809.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g03216001 hypothetical protein 48.67(n)
    39.19(a)    		   4335478  NM_001058998.1  NP_001052463.1 


    ENSEMBL Gene Tree for SUPT16H (if available)
    TreeFam Gene Tree for SUPT16H (if available) 

    Paralogs
    for SUPT16H gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUPT16H gene

    SUPT16H for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SUPT16H
    PGOHUM00000239361


    Genomic Variants
    for SUPT16H gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/620 NCBI SNPs in SUPT16H are shown (see all 620)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs455406361,2
    		--1939300(+) AATTTG/CGTTTA 1 -- ds50011Minor allele frequency- C:0.50NA 2
    rs770090111,2
    		--1939464(+) GTCACA/CGGTGA 1 -- ds50012Minor allele frequency- C:0.05CSA WA 120
    rs616115191,2
    		C,--1939852(+) GACTTG/TTCCCT 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs619775201,2
    		C,--1939915(+) CGGTAC/TATGAG 1 -- ut312Minor allele frequency- T:0.03NA 122
    rs80031601,2
    		C,F,A,H,--1939955(+) ATGAGA/GAAAAA 1 -- ut31 trp313Minor allele frequency- G:0.04NS EA NA WA 1526
    rs1115290311,2
    		--1940009(+) TGCATC/TGTATG 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs726847361,2
    		C,--1940014(+) TGTATA/GGAGAA 1 -- ut310--------
    rs735796261,2
    		C,--1940412(+) CAATAT/CTTATT 1 -- ut312Minor allele frequency- C:0.03WA 120
    rs80224801,2
    		C,F,H,--1940487(+) GGCACG/ATGTCC 1 -- ut31 ese37Minor allele frequency- A:0.05NS NA 970
    rs115545781,2
    		C,F,H,--1940505(-) GGAATT/GCCAGG 1 -- ut31 ese37Minor allele frequency- G:0.01NA NS EA 518

    HapMap Linkage Disequilibrium report for SUPT16H (21819631 - 21852425 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SUPT16H: --
    Human Gene Mutation Database (HGMD): SUPT16H

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    Disorders / Diseases
    for SUPT16H gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SUPT16H for disorders           About GeneDecksing

    OMIM gene information: 605012    OMIM disorders: --

    2 diseases for SUPT16H:    About MalaCards
    williams syndrome    malaria


    Export disorders for SUPT16H gene to outside databases

    Publications
    for SUPT16H gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUPT16H gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with SUPT16H)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. (PubMed id 11239457)1, 2, 3 Keller D.M....Lu H. (2001)
    2. FACT, a factor that facilitates transcript elongation through nucleosomes. (PubMed id 9489704)1, 2, 3 Orphanides G.... Reinberg D. (1998)
    3. FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. (PubMed id 10912001)1, 2, 9 Wada T.... Handa H. (2000)
    4. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. (PubMed id 10421373)1, 2, 9 Orphanides G.... Reinberg D. (1999)
    5. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Modulation of nucleosome-binding activity of FACT by poly(ADP- ribosyl)ation. (PubMed id 16682447)1, 2 Huang J.-Y....Lee S.-C. (2006)
    8. Nek9, a novel FACT-associated protein, modulates interphase progression. (PubMed id 14660563)1, 2 Tan B.C.-M. and Lee S.-C. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. FACT facilitates transcription-dependent nucleosome alteration. (PubMed id 12934006)1, 2 Belotserkovskaya R.... Reinberg D. (2003)

    External Searches for SUPT16H gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing SUPT16H gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11198 HGNC: 11465 AceView: SUPT16H Ensembl:ENSG00000092201 euGenes: HUgn11198
    ECgene: SUPT16H H-InvDB: SUPT16H

    Other Databases showing SUPT16H gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SUPT16H gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUPT16H Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SUPT16H gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SUPT16H gene:
    Search GeneIP for patents involving SUPT16H

    GeneCards and IP:
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