Aliases for SUPT16H Gene
- SPT16 Homolog, Facilitates Chromatin Remodeling Subunit 2 3 5
- Chromatin-Specific Transcription Elongation Factor 140 KDa Subunit 3 4
- Facilitates Chromatin Transcription Complex Subunit SPT16 3 4
- Facilitates Chromatin Remodeling 140 KDa Subunit 2 3
- FACT 140 KDa Subunit 3 4
- FACTP140 3 4
- HSPT16 3 4
- Suppressor Of Ty 16 Homolog (S. Cerevisiae) 2
External Ids for SUPT16H Gene
Previous GeneCards Identifiers for SUPT16H Gene
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
GeneCards Summary for SUPT16H Gene
SUPT16H (SPT16 Homolog, Facilitates Chromatin Remodeling Subunit) is a Protein Coding gene. Diseases associated with SUPT16H include Ceroid Lipofuscinosis, Neuronal, 2 and Leukoencephalopathy With Vanishing White Matter. Among its related pathways are HIV Life Cycle and Regulation of TP53 Activity. GO annotations related to this gene include poly(A) RNA binding.
UniProtKB/Swiss-Prot for SUPT16H Gene
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of Ser-392 of p53/TP53 via its association with CK2 (casein kinase II).