Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SUPT16H Gene

protein-coding   GIFtS: 56
GCID: GC14M021819

Suppressor Of Ty 16 Homolog (S. Cerevisiae)

(Previous name: suppressor of Ty (S.cerevisiae) 16 homolog)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Suppressor Of Ty 16 Homolog (S. Cerevisiae)1 2     Suppressor Of Ty (S.Cerevisiae) 16 Homolog1
Facilitates Chromatin Remodeling 140 KDa Subunit1 2     CDC682
Chromatin-Specific Transcription Elongation Factor 140 KDa Subunit2 3     SPT16/CDC682
Facilitates Chromatin Transcription Complex Subunit SPT162 3     FACT Complex Subunit SPT162
FACTP1402 3     FACT1403
FACT 140 KDa Subunit2 3     FACTp1403
hSPT162 3     

External Ids:    HGNC: 114651   Entrez Gene: 111982   Ensembl: ENSG000000922017   OMIM: 6050125   UniProtKB: Q9Y5B93   

Export aliases for SUPT16H gene to outside databases

Previous GC identifers: GC00U990361 GC14M015606 GC14M019809 GC14M020889 GC14M001939


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SUPT16H Gene:
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription
factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin,
indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin
transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription
elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit.
(provided by RefSeq, Feb 2009)

GeneCards Summary for SUPT16H Gene:
SUPT16H (suppressor of Ty 16 homolog (S. cerevisiae)) is a protein-coding gene.

UniProtKB/Swiss-Prot: SP16H_HUMAN, Q9Y5B9
Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT
complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication
and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both
destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and
transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently
promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is
probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase
II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a
chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound
VDR-mediated transrepression of the CYP27B1 gene

Gene Wiki entry for SUPT16H Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUPT16H gene promoter:
         E2F-3a   TBP   E2F   E2F-1   TFIID   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SUPT16H promoter sequence
   Search Chromatin IP Primers for SUPT16H

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUPT16H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

SUPT16H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUPT16H gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021819:  view genomic region     (about GC identifiers)

Start:
21,819,631 bp from pter      End:
21,852,425 bp from pter
Size:
32,795 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SP16H_HUMAN, Q9Y5B9 (See protein sequence)
Recommended Name: FACT complex subunit SPT16  
Size: 1047 amino acids; 119914 Da
Subunit: Interacts with MYOG (via C-terminus region) (By similarity). Component of the FACT complex, a stable
heterodimer of SSRP1 and SUPT16H. Also component of a CK2-SPT16-SSRP1 complex which forms following UV
irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B. Component of the WINAC complex, at least
composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H,
CHAF1A and TOP2B. Interacts with NEK9. Binds to histone H2A-H2B. Interacts with GTF2E2
Caution: Although related to the peptidase M24 family, this protein lacks conserved active site residues
suggesting that it may lack peptidase activity
Sequence caution: Sequence=AAH64561.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH73849.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q6GMT8 Q6P2F1 Q6PJM1 Q9NRX0

Explore the universe of human proteins at neXtProt for SUPT16H: NX_Q9Y5B9

Explore proteomics data for SUPT16H at MOPED

Post-translational modifications: 

  • ADP-ribosylated. ADP-ribosylation by PARP1 is induced by genotoxic stress and correlates with dissociation of FACT
    from chromatin1
  • Ubiquitination2 at Lys86, Lys120, Lys196, Lys280, Lys366, Lys426, Lys504, Lys513, Lys596, Lys647,
                                 Lys663, Lys674, Lys696, Lys781, Lys786, Lys904
  • Modification sites at PhosphoSitePlus

  • See SUPT16H Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009123.1  
    ENSEMBL proteins: 
     ENSP00000216297   ENSP00000452259   ENSP00000451517   ENSP00000450910  
    Reactome Protein details: Q9Y5B9

    SUPT16H Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SUPT16H
    GenScript Custom Purified and Recombinant Proteins Services for SUPT16H
    Novus Biologicals SUPT16H Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUPT16H

     
    Search eBioscience for Proteins for SUPT16H 

    SUPT16H Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SUPT16H  (SPT16)
    OriGene Antibodies for SUPT16H
    OriGene Custom Antibody Services for SUPT16H
    Novus Biologicals SUPT16H Antibodies
    Abcam antibodies for SUPT16H
    Cloud-Clone Corp. Antibodies for SUPT16H
    ThermoFisher Antibodies for SUPT16H
    LSBio Antibodies in human, mouse, rat for SUPT16H

    SUPT16H Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SUPT16H
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SUPT16H
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SUPT16H
    Cloud-Clone Corp. CLIAs for SUPT16H
    Search eBioscience for ELISAs for SUPT16H 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR013719 DUF1747
     IPR000994 Pept_M24_structural-domain
     IPR013953 FACT_Spt16p

    Graphical View of Domain Structure for InterPro Entry Q9Y5B9

    ProtoNet protein and cluster: Q9Y5B9

    2 Blocks protein domains:
    IPB013719 Domain of unknown function DUF1747
    IPB013953 FACT complex subunit Spt16p/Cdc68p


    UniProtKB/Swiss-Prot: SP16H_HUMAN, Q9Y5B9
    Domain: The Glu-rich acidic region in C-terminus is essential for FACT activity
    Similarity: Belongs to the peptidase M24 family. SPT16 subfamily


    Find genes that share domains with SUPT16H           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SP16H_HUMAN, Q9Y5B9
    Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT
    complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication
    and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both
    destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and
    transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently
    promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is
    probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase
    II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a
    chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound
    VDR-mediated transrepression of the CYP27B1 gene

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16902406
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SUPT16H           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUPT16H
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SUPT16H

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUPT16H
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUPT16H

    miRNA
    Products:
        
    miRTarBase miRNAs that target SUPT16H:
    hsa-let-7c-5p (MIRT051819), hsa-mir-25-3p (MIRT050293), hsa-mir-186-5p (MIRT045114), hsa-mir-339-5p (MIRT042786), hsa-mir-484 (MIRT041946), hsa-mir-16-5p (MIRT031692), hsa-let-7b-5p (MIRT052127), hsa-mir-877-3p (MIRT037170), hsa-mir-18a-3p (MIRT040787), hsa-mir-615-3p (MIRT039995), hsa-mir-296-3p (MIRT038337), hsa-mir-361-5p (MIRT044101)

    Block miRNA regulation of human, mouse, rat SUPT16H using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUPT16H (see all 46):
    hsa-miR-3678-3p hsa-miR-15a hsa-miR-877* hsa-miR-1273d hsa-miR-424 hsa-miR-654-5p hsa-miR-133a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSUPT16H 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SUPT16H
    Predesigned siRNA for gene silencing in human, mouse, rat SUPT16H

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SUPT16H

    Clone
    Products:
         
    OriGene clones in human, mouse for SUPT16H (see all 7)
    OriGene ORF clones in mouse, rat for SUPT16H
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SUPT16H (NM_007192)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUPT16H
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SUPT16H

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SUPT16H
    Browse ESI BIO Cell Lines and PureStem Progenitors for SUPT16H 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT16H


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SP16H_HUMAN, Q9Y5B9: Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to
    actively transcribed loci
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome IEA--

    Find genes that share ontologies with SUPT16H           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SUPT16H About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript0.77
    Pausing and recovery of HIV elongation0.73
    HIV Transcription Elongation0.77
    HIV elongation arrest and recovery0.73
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.77
    Pausing and recovery of Tat-mediated HIV elongation0.72
    RNA Polymerase II Transcription Elongation0.75
    Tat-mediated HIV elongation arrest and recovery0.72
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    3Gene Expression
    Gene Expression0.40
    4Disease
    Disease
    5Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with SUPT16H           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SUPT16H
        Chromatin Regulation / Acetylation

    Selected Reactome Pathways for SUPT16H (see all 10)
        Pausing and recovery of Tat-mediated HIV elongation
    Formation of RNA Pol II elongation complex
    Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Pausing and recovery of HIV elongation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SUPT16H
    Interactions:

        GeneGlobe Interaction Network for SUPT16H

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUPT16H (Q9Y5B91, 2, 3 ENSP000002162974) via UniProtKB, MINT, STRING, and/or I2D (see all 940)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=8 STRING: ENSP00000352980
    HIST1H4CP628053, ENSP000003670344I2D: score=8 STRING: ENSP00000367034
    HIST1H4DP628053, ENSP000003432824I2D: score=8 STRING: ENSP00000343282
    HIST1H4EP628053, ENSP000003536244I2D: score=8 STRING: ENSP00000353624
    HIST1H4HP628053, ENSP000002893524I2D: score=8 STRING: ENSP00000289352
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006281DNA repair IEA--
    GO:0006337nucleosome disassembly TAS10421373
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    Find genes that share ontologies with SUPT16H           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUPT16H (SP16H)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SUPT16H gene: 
    NM_007192.3  

    Unigene Cluster for SUPT16H:

    Suppressor of Ty 16 homolog (S. cerevisiae)
    Hs.213724  [show with all ESTs]
    Unigene Representative Sequence: NM_007192
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216297(uc001wao.2) ENST00000557394(uc001wan.2) ENST00000552829
    ENST00000556309 ENST00000556217 ENST00000557652 ENST00000555752 ENST00000555943(uc001waq.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SUPT16H using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUPT16H (see all 46):
    hsa-miR-3678-3p hsa-miR-15a hsa-miR-877* hsa-miR-1273d hsa-miR-424 hsa-miR-654-5p hsa-miR-133a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSUPT16H 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SUPT16H
    Predesigned siRNA for gene silencing in human, mouse, rat SUPT16H
    Clone
    Products:
         
    OriGene clones in human, mouse for SUPT16H (see all 7)
    OriGene ORF clones in mouse, rat for SUPT16H
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SUPT16H (NM_007192)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUPT16H
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SUPT16H
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SUPT16H
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUPT16H
      QuantiTect SYBR Green Assays in human, mouse, rat SUPT16H
      QuantiFast Probe-based Assays in human, mouse, rat SUPT16H

    Additional mRNA sequence: 

    AF164924.1 AK001719.1 AK024072.1 AK091676.1 BC000565.2 BC012582.1 BC014046.2 BC064561.1 
    BC073849.1 BC111402.1 

    21 DOTS entries:

    DT.448845  DT.100817530  DT.92452862  DT.100817531  DT.97788439  DT.100756355  DT.99976736  DT.120756997 
    DT.95186345  DT.100774288  DT.120756709  DT.121188430  DT.95101887  DT.120756769  DT.120756811  DT.120756849 
    DT.120756970  DT.95186358  DT.120757016  DT.75132147  DT.97856616 

    Selected AceView cDNA sequences (see all 357):

    BC073849 BU156436 BQ775979 BI223640 AA720952 BM852833 CB121141 BF797404 
    AI739097 BX117988 BG286896 AI560509 BE671605 BG576649 BM474309 CD742707 
    BQ961250 NM_007192 AI863092 BM016024 BQ049605 BE503636 AA317994 AI433214 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SUPT16H (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:              -           -     -     -                                                                                                                     
    SP2:                                                                                                                                                            
    SP3:                                      -                                                                                                                     
    SP4:              -                       -                                                                                                                     
    SP5:              -                                                                                                                                             

    ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for SUPT16H

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SUPT16H expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTGGGCCT
    SUPT16H Expression
    About this image


    SUPT16H expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Midgut
    SUPT16H Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUPT16H Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.213724

    UniProtKB/Swiss-Prot: SP16H_HUMAN, Q9Y5B9
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for SUPT16H
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SUPT16H
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUPT16H
    QuantiTect SYBR Green Assays in human, mouse, rat SUPT16H
    QuantiFast Probe-based Assays in human, mouse, rat SUPT16H
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT16H

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUPT16H gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Supt161 , 5 suppressor of Ty 16 homolog (S. cerevisiae)5
    suppressor of Ty 161
    90.83(n)1
    98.76(a)1
      14 (26.83 cM)5
    1147411  NM_033618.31  NP_291096.21 
     521604195 
    lizard
    (Anolis carolinensis)
    Reptilia SUPT16H6
    suppressor of Ty 16 homolog (S. cerevisiae)
    88(a)
    1 ↔ 1
    GL343466.1(381219-401753)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.79832 Xenopus laevis mRNA for DUF140, complete cds 79.71(n)    AB004794.2 
    zebrafish
    (Danio rerio)
    Actinopterygii supt16h1 suppressor of Ty 16 homolog 74.86(n)
    85.03(a)
      562348  NM_001097584.1  NP_001091053.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dre41 dre4 60.99(n)
    61.53(a)
      38248  NM_167922.3  NP_728686.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F55A3.31 F55A3.3 54.19(n)
    48.47(a)
      172984  NM_060420.4  NP_492821.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPT16(YGL207W)4
    SPT161
    Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), more4
    SPT161
    47.06(n)1
    37.87(a)1
      7(98969-102076)4
    8526651, 4  NP_011308.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SPT161 SPT16 48.49(n)
    37.99(a)
      826665  NM_117139.2  NP_192809.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g03216001 Os04g0321600 48.65(n)
    39.53(a)
      4335478  NM_001058998.1  NP_001052463.1 


    ENSEMBL Gene Tree for SUPT16H (if available)
    TreeFam Gene Tree for SUPT16H (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SUPT16H gene

    Find genes that share paralogs with SUPT16H           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SUPT16H
    PGOHUM00000239361


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SUPT16H (see all 785)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs616115191,2
    C,F--1939852(+) GACTTG/TTCCCT 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs1856531631,2
    --1939862(+) TTCCAC/GATATA 1 -- ut310--------
    rs22958651,2
    C,F,A,H--1939865(+) CAGATA/C/GTAAAT 2 -- ut31 ese322EA NA NS WA CSA 2506
    rs619775201,2
    C--1939915(+) CGGTAC/TATGAG 1 -- ut312Minor allele frequency- T:0.03NA 122
    rs80031601,2
    C,F,A,H--1939955(+) ATGAGA/GAAAAA 1 -- ut31 trp313Minor allele frequency- G:0.04NS EA NA WA 1526
    rs1115290311,2
    C,F--1940009(+) TGCATC/TGTATG 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs726847361,2
    C--1940014(+) TGTATA/GGAGAA 1 -- ut310--------
    rs1425447561,2
    C--1940029(+) ACCGAA/GCCAGG 1 -- ut310--------
    rs2013533651,2
    C--1940068(+) GCAGC-/AGAT  
            
    AGATA
    1 -- ut310--------
    rs1509652791,2
    C--1940100(+) CAGGAA/GAGCAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SUPT16H (21819631 - 21852425 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SUPT16H: --
    Human Gene Mutation Database (HGMD): SUPT16H
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUPT16H
    DNA2.0 Custom Variant and Variant Library Synthesis for SUPT16H

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605012    OMIM disorders: --


    Find genes that share disorders with SUPT16H           About GenesLikeMe


    Export disorders for SUPT16H gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SUPT16H gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with SUPT16H)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. (PubMed id 11239457)1, 2, 3 Keller D.M.... Lu H. (Mol. Cell 2001)
    2. FACT, a factor that facilitates transcript elongation through nucleosomes. (PubMed id 9489704)1, 2, 3 Orphanides G.... Reinberg D. (Cell 1998)
    3. FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. (PubMed id 10912001)1, 2, 9 Wada T.... Handa H. (Mol. Cell 2000)
    4. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. (PubMed id 10421373)1, 2, 9 Orphanides G.... Reinberg D. (Nature 1999)
    5. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (Cell 2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Modulation of nucleosome-binding activity of FACT by poly(ADP- ribosyl)ation. (PubMed id 16682447)1, 2 Huang J.-Y....Lee S.-C. (Nucleic Acids Res. 2006)
    8. Nek9, a novel FACT-associated protein, modulates interphase progression. (PubMed id 14660563)1, 2 Tan B.C.-M. and Lee S.-C. (J. Biol. Chem. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. FACT facilitates transcription-dependent nucleosome alteration. (PubMed id 12934006)1, 2 Belotserkovskaya R.... Reinberg D. (Science 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 11198 HGNC: 11465 AceView: SUPT16H Ensembl:ENSG00000092201 euGenes: HUgn11198
    ECgene: SUPT16H H-InvDB: SUPT16H

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SUPT16H Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SUPT16H gene:
    Search GeneIP for patents involving SUPT16H

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SUPT16H   OriGene RNAi products in human, mouse, rat for SUPT16H  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SUPT16H  
     OriGene qSTAR qPCR primer pairs in human, mouse for SUPT16H   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SUPT16H   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SUPT16H   OriGene Custom Protein Services for SUPT16H  

     
     
     Block miRNA regulation of human, mouse, rat SUPT16H using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SUPT16H
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUPT16H Predesigned siRNA for gene silencing in human, mouse, rat SUPT16H
     QuantiFast Probe-based Assays in human, mouse, rat SUPT16H QuantiTect SYBR Green Assays in human, mouse, rat SUPT16H
     Custom PCR Arrays for SUPT16H Search Chromatin IP Primers for SUPT16H
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUPT16H  GeneGlobe Interaction Network for SUPT16H
     Regulatory tfbs in SUPT16H promoter
     GenScript Custom Purified and Recombinant Proteins Services for SUPT16H GenScript cDNA clones with any tag delivered in your preferred vector for SUPT16H
     GenScript Custom Assay Services for SUPT16H GenScript Custom overexpressing Cell Line Services for SUPT16H
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for SUPT16H  (SPT16)

     Search Tocris compounds for SUPT16H (SP16H)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SUPT16H antibodies
     SUPT16H proteins
     Antibodies for SUPT16H
     See all of Abcam's Antibodies, Kits and Proteins for SUPT16H
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SUPT16H
     Antibodies for SUPT16H
     ELISAs for SUPT16H
     CLIAs for SUPT16H



     Browse ESI BIO Cell Lines and PureStem Progenitors for SUPT16H
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT16H
     SwitchGear 3'UTR luciferase reporter plasmids for SUPT16H
     SwitchGear Promoter luciferase reporter plasmids for SUPT16H
     ThermoFisher Antibodies for SUPT16H
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SUPT16H
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUPT16H
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SUPT16H
     LSBio Antibodies in human, mouse, rat for SUPT16H
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SUPT16H
      Search eBioscience for proteins for SUPT16H
      Search eBioscience for elisas for SUPT16H
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SUPT16H gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4