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Aliases for SUPT16H Gene

Aliases for SUPT16H Gene

  • SPT16 Homolog, Facilitates Chromatin Remodeling Subunit 2 3 5
  • Chromatin-Specific Transcription Elongation Factor 140 KDa Subunit 3 4
  • Facilitates Chromatin Transcription Complex Subunit SPT16 3 4
  • Facilitates Chromatin Remodeling 140 KDa Subunit 2 3
  • FACT 140 KDa Subunit 3 4
  • FACTP140 3 4
  • HSPT16 3 4
  • Suppressor Of Ty 16 Homolog (S. Cerevisiae) 2
  • Suppressor Of Ty (S.Cerevisiae) 16 Homolog 2
  • Suppressor Of Ty 16 Homolog 3
  • SPT16/CDC68 3
  • FACT140 4
  • CDC68 3
  • SPT16 3

External Ids for SUPT16H Gene

Previous GeneCards Identifiers for SUPT16H Gene

  • GC00U990361
  • GC14M015606
  • GC14M019809
  • GC14M020889
  • GC14M021819
  • GC14M001939

Summaries for SUPT16H Gene

Entrez Gene Summary for SUPT16H Gene

  • Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]

GeneCards Summary for SUPT16H Gene

SUPT16H (SPT16 Homolog, Facilitates Chromatin Remodeling Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and HIV Life Cycle. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for SUPT16H Gene

  • Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of Ser-392 of p53/TP53 via its association with CK2 (casein kinase II).

Gene Wiki entry for SUPT16H Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT16H Gene

Genomics for SUPT16H Gene

Regulatory Elements for SUPT16H Gene

Promoters for SUPT16H Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUPT16H on UCSC Golden Path with GeneCards custom track

Genomic Location for SUPT16H Gene

Chromosome:
14
Start:
21,351,472 bp from pter
End:
21,384,639 bp from pter
Size:
33,168 bases
Orientation:
Minus strand

Genomic View for SUPT16H Gene

Genes around SUPT16H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUPT16H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUPT16H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPT16H Gene

Proteins for SUPT16H Gene

  • Protein details for SUPT16H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5B9-SP16H_HUMAN
    Recommended name:
    FACT complex subunit SPT16
    Protein Accession:
    Q9Y5B9
    Secondary Accessions:
    • Q6GMT8
    • Q6P2F1
    • Q6PJM1
    • Q9NRX0

    Protein attributes for SUPT16H Gene

    Size:
    1047 amino acids
    Molecular mass:
    119914 Da
    Quaternary structure:
    • Interacts with MYOG (via C-terminal region) (By similarity). Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H. Also component of a CK2-SPT16-SSRP1 complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B. Interacts with NEK9. Binds to histone H2A-H2B. Interacts with GTF2E2.
    SequenceCaution:
    • Sequence=AAH64561.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH73849.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUPT16H Gene

neXtProt entry for SUPT16H Gene

Proteomics data for SUPT16H Gene at MOPED

Post-translational modifications for SUPT16H Gene

  • ADP-ribosylated. ADP-ribosylation by PARP1 is induced by genotoxic stress and correlates with dissociation of FACT from chromatin.
  • Ubiquitination at Lys 86, Lys 120, Lys 196, Lys 280, Lys 366, Lys 426, Lys 504, Lys 513, Lys 596, Lys 663, Lys 696, Lys 781, Lys 786, and Lys 904
  • Modification sites at PhosphoSitePlus

Other Protein References for SUPT16H Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SUPT16H (SPT16)

No data available for DME Specific Peptides for SUPT16H Gene

Domains & Families for SUPT16H Gene

Suggested Antigen Peptide Sequences for SUPT16H Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5B9

UniProtKB/Swiss-Prot:

SP16H_HUMAN :
  • The C-terminal Glu-rich acidic region is essential for FACT activity.
  • Belongs to the peptidase M24 family. SPT16 subfamily.
Domain:
  • The C-terminal Glu-rich acidic region is essential for FACT activity.
Family:
  • Belongs to the peptidase M24 family. SPT16 subfamily.
genes like me logo Genes that share domains with SUPT16H: view

No data available for Gene Families for SUPT16H Gene

Function for SUPT16H Gene

Molecular function for SUPT16H Gene

UniProtKB/Swiss-Prot Function:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of Ser-392 of p53/TP53 via its association with CK2 (casein kinase II).
genes like me logo Genes that share phenotypes with SUPT16H: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SUPT16H

CRISPR Products

miRNA for SUPT16H Gene

miRTarBase miRNAs that target SUPT16H

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUPT16H Gene

Localization for SUPT16H Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUPT16H Gene

Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUPT16H Gene COMPARTMENTS Subcellular localization image for SUPT16H gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for SUPT16H Gene

Pathways & Interactions for SUPT16H Gene

genes like me logo Genes that share pathways with SUPT16H: view

Pathways by source for SUPT16H Gene

Gene Ontology (GO) - Biological Process for SUPT16H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006337 nucleosome disassembly TAS 10421373
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0016032 viral process TAS --
GO:0032786 positive regulation of DNA-templated transcription, elongation TAS 10421373
genes like me logo Genes that share ontologies with SUPT16H: view

No data available for SIGNOR curated interactions for SUPT16H Gene

Drugs & Compounds for SUPT16H Gene

No Compound Related Data Available

Transcripts for SUPT16H Gene

Unigene Clusters for SUPT16H Gene

Suppressor of Ty 16 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUPT16H Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2:
SP3: -
SP4: - -
SP5: -
SP6:

ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for SUPT16H Gene

GeneLoc Exon Structure for
SUPT16H
ECgene alternative splicing isoforms for
SUPT16H

Expression for SUPT16H Gene

mRNA expression in normal human tissues for SUPT16H Gene

Protein differential expression in normal tissues from HIPED for SUPT16H Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1), Tlymphocyte (9.2), and Fetal ovary (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUPT16H Gene



SOURCE GeneReport for Unigene cluster for SUPT16H Gene Hs.213724

mRNA Expression by UniProt/SwissProt for SUPT16H Gene

Q9Y5B9-SP16H_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with SUPT16H: view

Protein tissue co-expression partners for SUPT16H Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SUPT16H Gene

Orthologs for SUPT16H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUPT16H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUPT16H 35
  • 99.68 (n)
  • 100 (a)
SUPT16H 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUPT16H 36
  • 100 (a)
OneToOne
SUPT16H 35
  • 93.73 (n)
  • 99.71 (a)
dog
(Canis familiaris)
Mammalia SUPT16H 35
  • 94.14 (n)
  • 99.81 (a)
SUPT16H 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Supt16 36
  • 99 (a)
OneToOne
Supt16 35
  • 90.83 (n)
  • 98.76 (a)
Supt16 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SUPT16H 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Supt16h 35
  • 90.29 (n)
  • 99.04 (a)
lizard
(Anolis carolinensis)
Reptilia SUPT16H 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7983 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14979 35
zebrafish
(Danio rerio)
Actinopterygii supt16h 35
  • 74.86 (n)
  • 85.03 (a)
supt16h 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006817 35
  • 60.54 (n)
  • 61.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta dre4 35
  • 60.99 (n)
  • 61.53 (a)
dre4 36
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F55A3.3 36
  • 47 (a)
OneToMany
F55A3.7 36
  • 42 (a)
OneToMany
F55A3.3 35
  • 54.19 (n)
  • 48.47 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER360C 35
  • 48.85 (n)
  • 37.57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPT16 35
  • 47.06 (n)
  • 37.87 (a)
SPT16 36
  • 34 (a)
OneToOne
SPT16 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09889g 35
  • 47.57 (n)
  • 37.91 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SPT16 35
  • 48.49 (n)
  • 37.99 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10981 35
rice
(Oryza sativa)
Liliopsida Os04g0321600 35
  • 48.65 (n)
  • 39.53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01164 35
  • 49.4 (n)
  • 38.93 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spt16 35
  • 50.77 (n)
  • 40.66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2568 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10932 36
  • 55 (a)
OneToOne
Species with no ortholog for SUPT16H:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUPT16H Gene

ENSEMBL:
Gene Tree for SUPT16H (if available)
TreeFam:
Gene Tree for SUPT16H (if available)

Paralogs for SUPT16H Gene

Pseudogenes.org Pseudogenes for SUPT16H Gene

genes like me logo Genes that share paralogs with SUPT16H: view

No data available for Paralogs for SUPT16H Gene

Variants for SUPT16H Gene

Sequence variations from dbSNP and Humsavar for SUPT16H Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1060614 -- 21,362,872(-) AAGAT(C/G)TACAT reference, missense
rs1008268 -- 21,381,773(+) cctgg(C/T)taatt intron-variant
rs1008269 -- 21,381,841(+) gtctt(C/T)aactc intron-variant
rs1138450 -- 21,377,716(-) AACCC(A/G)GGAGG intron-variant
rs2181125 -- 21,370,001(+) TAGCA(A/G)ACTAT intron-variant

Variation tolerance for SUPT16H Gene

Residual Variation Intolerance Score: 7.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUPT16H Gene

HapMap Linkage Disequilibrium report
SUPT16H
Human Gene Mutation Database (HGMD)
SUPT16H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SUPT16H Gene

Disorders for SUPT16H Gene

Relevant External Links for SUPT16H

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUPT16H

No disorders were found for SUPT16H Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUPT16H Gene

Publications for SUPT16H Gene

  1. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. (PMID: 11239457) Keller D.M. … Lu H. (Mol. Cell 2001) 2 3 4 67
  2. FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. (PMID: 10912001) Wada T. … Handa H. (Mol. Cell 2000) 3 23
  3. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. (PMID: 10421373) Orphanides G. … Reinberg D. (Nature 1999) 3 23
  4. FACT, a factor that facilitates transcript elongation through nucleosomes. (PMID: 9489704) Orphanides G. … Reinberg D. (Cell 1998) 2 3
  5. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3

Products for SUPT16H Gene

Sources for SUPT16H Gene

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