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Aliases for SUPT16H Gene

Aliases for SUPT16H Gene

  • Suppressor Of Ty 16 Homolog (S. Cerevisiae) 2 3
  • Chromatin-Specific Transcription Elongation Factor 140 KDa Subunit 3 4
  • Facilitates Chromatin Transcription Complex Subunit SPT16 3 4
  • Facilitates Chromatin Remodeling 140 KDa Subunit 2 3
  • FACT 140 KDa Subunit 3 4
  • FACTP140 3 4
  • HSPT16 3 4
  • Suppressor Of Ty (S.Cerevisiae) 16 Homolog 2
  • FACT Complex Subunit SPT16 3
  • SPT16/CDC68 3
  • FACT140 4
  • CDC68 3
  • SPT16 3

External Ids for SUPT16H Gene

Previous GeneCards Identifiers for SUPT16H Gene

  • GC00U990361
  • GC14M015606
  • GC14M019809
  • GC14M020889
  • GC14M021819
  • GC14M001939

Summaries for SUPT16H Gene

Entrez Gene Summary for SUPT16H Gene

  • Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]

GeneCards Summary for SUPT16H Gene

SUPT16H (Suppressor Of Ty 16 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Disease and Gene Expression.

UniProtKB/Swiss-Prot for SUPT16H Gene

  • Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of Ser-392 of p53/TP53 via its association with CK2 (casein kinase II).

Gene Wiki entry for SUPT16H Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT16H Gene

Genomics for SUPT16H Gene

Regulatory Elements for SUPT16H Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUPT16H Gene

Start:
21,351,472 bp from pter
End:
21,384,266 bp from pter
Size:
32,795 bases
Orientation:
Minus strand

Genomic View for SUPT16H Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUPT16H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPT16H Gene

Proteins for SUPT16H Gene

  • Protein details for SUPT16H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5B9-SP16H_HUMAN
    Recommended name:
    FACT complex subunit SPT16
    Protein Accession:
    Q9Y5B9
    Secondary Accessions:
    • Q6GMT8
    • Q6P2F1
    • Q6PJM1
    • Q9NRX0

    Protein attributes for SUPT16H Gene

    Size:
    1047 amino acids
    Molecular mass:
    119914 Da
    Quaternary structure:
    • Interacts with MYOG (via C-terminal region) (By similarity). Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H. Also component of a CK2-SPT16-SSRP1 complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B. Interacts with NEK9. Binds to histone H2A-H2B. Interacts with GTF2E2.
    SequenceCaution:
    • Sequence=AAH64561.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH73849.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for SUPT16H Gene

Proteomics data for SUPT16H Gene at MOPED

Post-translational modifications for SUPT16H Gene

  • ADP-ribosylated. ADP-ribosylation by PARP1 is induced by genotoxic stress and correlates with dissociation of FACT from chromatin
  • Ubiquitination at Lys86, Lys120, Lys196, Lys280, Lys366, Lys426, Lys504, Lys513, Lys596, Lys647, Lys663, Lys674, Lys696, Lys781, Lys786, and Lys904
  • Modification sites at PhosphoSitePlus

Other Protein References for SUPT16H Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SUPT16H (SPT16)

No data available for DME Specific Peptides for SUPT16H Gene

Domains for SUPT16H Gene

Suggested Antigen Peptide Sequences for SUPT16H Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5B9

UniProtKB/Swiss-Prot:

SP16H_HUMAN :
  • Q9Y5B9
Domain:
  • The C-terminal Glu-rich acidic region is essential for FACT activity.
Family:
  • Belongs to the peptidase M24 family. SPT16 subfamily.
genes like me logo Genes that share domains with SUPT16H: view

No data available for Gene Families for SUPT16H Gene

Function for SUPT16H Gene

Molecular function for SUPT16H Gene

UniProtKB/Swiss-Prot Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of Ser-392 of p53/TP53 via its association with CK2 (casein kinase II).

Gene Ontology (GO) - Molecular Function for SUPT16H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16902406
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SUPT16H: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUPT16H

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SUPT16H Gene

Localization for SUPT16H Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUPT16H Gene

Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUPT16H Gene COMPARTMENTS Subcellular localization image for SUPT16H gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SUPT16H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with SUPT16H: view

Pathways for SUPT16H Gene

genes like me logo Genes that share pathways with SUPT16H: view

Pathways by source for SUPT16H Gene

1 Cell Signaling Technology pathway for SUPT16H Gene

Gene Ontology (GO) - Biological Process for SUPT16H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006281 DNA repair IEA --
GO:0006337 nucleosome disassembly TAS 10421373
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with SUPT16H: view

Transcripts for SUPT16H Gene

Unigene Clusters for SUPT16H Gene

Suppressor of Ty 16 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUPT16H

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SUPT16H

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUPT16H Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2:
SP3: -
SP4: - -
SP5: -
SP6:

ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for SUPT16H Gene

GeneLoc Exon Structure for
SUPT16H
ECgene alternative splicing isoforms for
SUPT16H

Expression for SUPT16H Gene

mRNA expression in normal human tissues for SUPT16H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUPT16H Gene

SOURCE GeneReport for Unigene cluster for SUPT16H Gene Hs.213724

mRNA Expression by UniProt/SwissProt for SUPT16H Gene

Q9Y5B9-SP16H_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with SUPT16H: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SUPT16H Gene

Orthologs for SUPT16H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUPT16H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUPT16H 35
  • 99.68 (n)
  • 100 (a)
SUPT16H 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUPT16H 35
  • 93.73 (n)
  • 99.71 (a)
SUPT16H 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUPT16H 35
  • 94.14 (n)
  • 99.81 (a)
SUPT16H 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Supt16 35
  • 90.83 (n)
  • 98.76 (a)
Supt16 16
Supt16 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SUPT16H 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Supt16h 35
  • 90.29 (n)
  • 99.04 (a)
lizard
(Anolis carolinensis)
Reptilia SUPT16H 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7983 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14979 35
zebrafish
(Danio rerio)
Actinopterygii supt16h 35
  • 74.86 (n)
  • 85.03 (a)
supt16h 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006817 35
  • 60.54 (n)
  • 61.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta dre4 35
  • 60.99 (n)
  • 61.53 (a)
dre4 36
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F55A3.3 35
  • 54.19 (n)
  • 48.47 (a)
F55A3.3 36
  • 47 (a)
OneToMany
F55A3.7 36
  • 42 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER360C 35
  • 48.85 (n)
  • 37.57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPT16 35
  • 47.06 (n)
  • 37.87 (a)
SPT16 36
  • 34 (a)
OneToOne
SPT16 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09889g 35
  • 47.57 (n)
  • 37.91 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SPT16 35
  • 48.49 (n)
  • 37.99 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10981 35
rice
(Oryza sativa)
Liliopsida Os04g0321600 35
  • 48.65 (n)
  • 39.53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01164 35
  • 49.4 (n)
  • 38.93 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spt16 35
  • 50.77 (n)
  • 40.66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2568 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10932 36
  • 55 (a)
OneToOne
Species with no ortholog for SUPT16H:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUPT16H Gene

ENSEMBL:
Gene Tree for SUPT16H (if available)
TreeFam:
Gene Tree for SUPT16H (if available)

Paralogs for SUPT16H Gene

Pseudogenes.org Pseudogenes for SUPT16H Gene

genes like me logo Genes that share paralogs with SUPT16H: view

No data available for Paralogs for SUPT16H Gene

Variants for SUPT16H Gene

Sequence variations from dbSNP and Humsavar for SUPT16H Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs927412 -- 21,360,361(+) CTGAG(A/T)GAAAT intron-variant
rs1008268 -- 21,381,773(+) cctgg(C/T)taatt intron-variant
rs1008269 -- 21,381,841(+) gtctt(C/T)aactc intron-variant
rs1060614 -- 21,362,872(-) AAGAT(C/G)TACAT reference, missense
rs1061306 -- 21,377,802(-) TACTA(A/G)AAATA intron-variant

Relevant External Links for SUPT16H Gene

HapMap Linkage Disequilibrium report
SUPT16H
Human Gene Mutation Database (HGMD)
SUPT16H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SUPT16H Gene

Disorders for SUPT16H Gene

No disorders were found for SUPT16H Gene.

No data available for UniProtKB/Swiss-Prot for SUPT16H Gene

Publications for SUPT16H Gene

  1. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. (PMID: 10421373) Orphanides G. … Reinberg D. (Nature 1999) 3 4 23
  2. FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. (PMID: 10912001) Wada T. … Handa H. (Mol. Cell 2000) 3 4 23
  3. FACT, a factor that facilitates transcript elongation through nucleosomes. (PMID: 9489704) Orphanides G. … Reinberg D. (Cell 1998) 2 3 4
  4. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. (PMID: 11239457) Keller D.M. … Lu H. (Mol. Cell 2001) 2 3 4
  5. p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. (PMID: 12393879) Keller D.M. … Lu H. (J. Biol. Chem. 2002) 3 4

Products for SUPT16H Gene

Sources for SUPT16H Gene

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