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GIFtS

SUPT16H Gene

protein-coding   GIFtS: 55
GCID: GC14M021819

Suppressor Of Ty 16 Homolog (S. Cerevisiae)

(Previous name: suppressor of Ty (S.cerevisiae) 16 homolog)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppressor Of Ty 16 Homolog (S. Cerevisiae)1 2     Suppressor Of Ty (S.Cerevisiae) 16 Homolog1
Facilitates Chromatin Remodeling 140 KDa Subunit1 2     CDC682
Chromatin-Specific Transcription Elongation Factor 140 KDa Subunit2 3     SPT16/CDC682
Facilitates Chromatin Transcription Complex Subunit SPT162 3     FACT Complex Subunit SPT162
FACTP1402 3     FACT1403
FACT 140 KDa Subunit2 3     FACTp1403
hSPT162 3     

External Ids:    HGNC: 114651   Entrez Gene: 111982   Ensembl: ENSG000000922017   OMIM: 6050125   UniProtKB: Q9Y5B93   

Export aliases for SUPT16H gene to outside databases

Previous GC identifers: GC00U990361 GC14M015606 GC14M019809 GC14M020889 GC14M001939


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUPT16H Gene:
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription
factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin,
indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin
transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription
elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit.
(provided by RefSeq, Feb 2009)

GeneCards Summary for SUPT16H Gene: 
SUPT16H (suppressor of Ty 16 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with SUPT16H include williams syndrome, and breast cancer, and among its related super-pathways are Formation of the Early Elongation Complex and HIV Life Cycle.

UniProtKB/Swiss-Prot: SP16H_HUMAN, Q9Y5B9
Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT
complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication
and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both
destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and
transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently
promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is
probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase
II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a
chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound
VDR-mediated transrepression of the CYP27B1 gene (By similarity)

Gene Wiki entry for SUPT16H Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUPT16H gene promoter:
         E2F-3a   TBP   E2F   E2F-1   TFIID   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SUPT16H promoter sequence
   Search SABiosciences Chromatin IP Primers for SUPT16H

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUPT16H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

SUPT16H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUPT16H gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021819:  view genomic region     (about GC identifiers)

Start:
21,819,631 bp from pter      End:
21,852,425 bp from pter
Size:
32,795 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SP16H_HUMAN, Q9Y5B9 (See protein sequence)
Recommended Name: FACT complex subunit SPT16  
Size: 1047 amino acids; 119914 Da
Subunit: Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H. Also component of a
CK2-SPT16-SSRP1 complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and
CSNK2B. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2,
SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Interacts with NEK9. Binds to histone
H2A-H2B. Interacts with GTF2E2
Subcellular location: Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to
actively transcribed loci
Caution: Although related to the peptidase M24 family, this protein lacks conserved active site residues
suggesting that it may lack peptidase activity
Sequence caution: Sequence=AAH64561.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH73849.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q6GMT8 Q6P2F1 Q6PJM1 Q9NRX0

Explore the universe of human proteins at neXtProt for SUPT16H: NX_Q9Y5B9

Explore proteomics data for SUPT16H at MOPED 

Post-translational modifications:

  • UniProtKB: ADP-ribosylated. ADP-ribosylation by PARP1 is induced by genotoxic stress and correlates with dissociation of FACT
    from chromatin
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5B9

  • SUPT16H Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SUPT16H Protein Expression
    REFSEQ proteins: NP_009123.1  
    ENSEMBL proteins: 
     ENSP00000216297   ENSP00000452259   ENSP00000451517   ENSP00000450910  
    Reactome Protein details: Q9Y5B9
    Human Recombinant Protein Products for SUPT16H: 
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    Novus Biologicals SUPT16H Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUPT16H 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome IEA--

    SUPT16H for ontologies           About GeneDecksing



    SUPT16H Antibody Products: 
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    Novus Biologicals SUPT16H Antibodies
    Abcam antibodies for SUPT16H
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    ThermoFisher Antibodies for SUPT16H
    LSBio Antibodies in human, mouse, rat for SUPT16H 

    Assay Products for SUPT16H: 
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    GenScript Custom Assay Services for SUPT16H
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SUPT16H 
    Cloud-Clone Corp. CLIAs for SUPT16H


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013719 DUF1747
     IPR000994 Pept_M24_structural-domain
     IPR013953 FACT_Spt16p

    Graphical View of Domain Structure for InterPro Entry Q9Y5B9

    ProtoNet protein and cluster: Q9Y5B9

    2 Blocks protein domains:
    IPB013719 Domain of unknown function DUF1747
    IPB013953 FACT complex subunit Spt16p/Cdc68p


    UniProtKB/Swiss-Prot: SP16H_HUMAN, Q9Y5B9
    Domain: The Glu-rich acidic region in C-terminus is essential for FACT activity
    Similarity: Belongs to the peptidase M24 family. SPT16 subfamily


    SUPT16H for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SP16H_HUMAN, Q9Y5B9
    Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT
    complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication
    and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both
    destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and
    transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently
    promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is
    probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase
    II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a
    chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound
    VDR-mediated transrepression of the CYP27B1 gene (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16902406
         
    SUPT16H for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SUPT16H 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUPT16H

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUPT16H 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUPT16H 

    miRNA
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    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate SUPT16H (see all 46):
    hsa-miR-3678-3p hsa-miR-15a hsa-miR-877* hsa-miR-1273d hsa-miR-424 hsa-miR-654-5p hsa-miR-133a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSUPT16H 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUPT16H


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SUPT16H About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript0.78
    HIV elongation arrest and recovery0.74
    HIV Transcription Elongation0.78
    Pausing and recovery of HIV elongation0.74
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.78
    Pausing and recovery of Tat-mediated HIV elongation0.73
    Formation of HIV elongation complex in the absence of HIV Tat0.76
    Tat-mediated HIV elongation arrest and recovery0.73
    2HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    3Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    4Generic Transcription Pathway
    Gene Expression0.47
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SUPT16H
        Chromatin Regulation / Acetylation

    5/20        Reactome Pathways for SUPT16H (see all 20)
        Formation of RNA Pol II elongation complex
    Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Late Phase of HIV Life Cycle



    SUPT16H for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SUPT16H

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/819 Interacting proteins for SUPT16H (Q9Y5B92, 3 ENSP000002162974) via UniProtKB, MINT, STRING, and/or I2D (see all 819)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=8 
    HIST1H4BP628053I2D: score=8 
    HIST1H4CP628053I2D: score=8 
    HIST1H4DP628053I2D: score=8 
    HIST1H4EP628053I2D: score=8 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006281DNA repair IEA--
    GO:0006337nucleosome disassembly TAS10421373
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    SUPT16H for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUPT16H (SP16H)

    Search CenterWatch for drugs/clinical trials and news about SUPT16H / SP16H

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUPT16H gene: 
    NM_007192.3  

    Unigene Cluster for SUPT16H:

    Suppressor of Ty 16 homolog (S. cerevisiae)
    Hs.213724  [show with all ESTs]
    Unigene Representative Sequence: NM_007192
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216297(uc001wao.2) ENST00000557394(uc001wan.2) ENST00000552829
    ENST00000556309 ENST00000556217 ENST00000557652 ENST00000555752 ENST00000555943(uc001waq.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate SUPT16H (see all 46):
    hsa-miR-3678-3p hsa-miR-15a hsa-miR-877* hsa-miR-1273d hsa-miR-424 hsa-miR-654-5p hsa-miR-133a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSUPT16H 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SUPT16H (NM_007192)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUPT16H
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SUPT16H
    Sirion Biotech Customized lentivirus for stable overexpression of SUPT16H 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUPT16H

    Additional mRNA sequence: 

    AF164924.1 AK001719.1 AK024072.1 AK091676.1 BC000565.2 BC012582.1 BC014046.2 BC064561.1 
    BC073849.1 BC111402.1 

    21 DOTS entries:

    DT.448845  DT.100817530  DT.92452862  DT.100817531  DT.97788439  DT.100756355  DT.99976736  DT.120756997 
    DT.95186345  DT.100774288  DT.120756709  DT.121188430  DT.95101887  DT.120756769  DT.120756811  DT.120756849 
    DT.120756970  DT.95186358  DT.120757016  DT.75132147  DT.97856616 

    24/357 AceView cDNA sequences (see all 357):

    BQ184243 BQ944241 AI565907 BU156107 BC073849 AI357284 AA720952 AA911237 
    BM969465 AA476670 BG681707 BE671605 BM852833 BG286896 BM823830 CR612151 
    AA985210 BP358828 AI583320 BM480104 AI433214 BF797404 BM766873 BQ961250 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SUPT16H (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:              -           -     -     -                                                                                                                     
    SP2:                                                                                                                                                            
    SP3:                                      -                                                                                                                     
    SP4:              -                       -                                                                                                                     
    SP5:              -                                                                                                                                             

    ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for SUPT16H

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUPT16H expression in normal human tissues (normalized intensities)      SUPT16H embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTGGGCCT
    SUPT16H Expression
    About this image


    SUPT16H expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Testis Somatic Cells Primitive Gonad
             testis ; cells in seminiferus ducts   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Autopod Long Bone
             skeleton/cranium/viscerocranium   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See SUPT16H Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUPT16H

    SOURCE GeneReport for Unigene cluster: Hs.213724

    UniProtKB/Swiss-Prot: SP16H_HUMAN, Q9Y5B9
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUPT16H gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Supt165
    Supt16h1
    suppressor of Ty 16 homolog (S. cerevisiae)1, 5 90.83(n)1
    98.76(a)1
      14 (26.83 cM)5
    1147411  NM_033618.31  NP_291096.21 
     521604195 
    lizard
    (Anolis carolinensis)
    Reptilia SUPT16H6
    Uncharacterized protein
    88(a)
    1 ↔ 1
    GL343466.1(381219-401753)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.79832 Xenopus laevis mRNA for DUF140, complete cds 79.71(n)    AB004794.2 
    zebrafish
    (Danio rerio)
    Actinopterygii supt16h1 suppressor of Ty 16 homolog 74.89(n)
    85.03(a)
      562348  NM_001097584.1  NP_001091053.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dre41 CG1828-PA 60.59(n)
    61.1(a)
      38248  NM_057262.3  NP_476610.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F55A3.31 Protein F55A3.3 54.19(n)
    48.97(a)
      172984  NM_060420.3  NP_492821.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPT16(YGL207W)4
    SPT161
    Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), more4
    Spt16p1
    46.81(n)1
    37.56(a)1
      7(98969-102076)4
    8526651, 4  NP_011308.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SPT161 FACT complex subunit SPT16 48.5(n)
    37.65(a)
      826665  NM_117139.2  NP_192809.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g03216001 hypothetical protein 48.67(n)
    39.19(a)
      4335478  NM_001058998.1  NP_001052463.1 


    ENSEMBL Gene Tree for SUPT16H (if available)
    TreeFam Gene Tree for SUPT16H (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUPT16H gene

    SUPT16H for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SUPT16H
    PGOHUM00000239361


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/785 SNPs in SUPT16H are shown (see all 785)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs616115191,2
    C,F--1939852(+) GACTTG/TTCCCT 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs1856531631,2
    --1939862(+) TTCCAC/GATATA 1 -- ut310--------
    rs22958651,2
    C,F,A,H--1939865(+) CAGATA/C/GTAAAT 2 -- ut31 ese322EA NA NS WA CSA 2506
    rs619775201,2
    C--1939915(+) CGGTAC/TATGAG 1 -- ut312Minor allele frequency- T:0.03NA 122
    rs80031601,2
    C,F,A,H--1939955(+) ATGAGA/GAAAAA 1 -- ut31 trp313Minor allele frequency- G:0.04NS EA NA WA 1526
    rs1115290311,2
    C,F--1940009(+) TGCATC/TGTATG 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs726847361,2
    C--1940014(+) TGTATA/GGAGAA 1 -- ut310--------
    rs1425447561,2
    C--1940029(+) ACCGAA/GCCAGG 1 -- ut310--------
    rs2013533651,2
    C--1940068(+) GCAGC-/AGAT  
            
    AGATA
    1 -- ut310--------
    rs1509652791,2
    C--1940100(+) CAGGAA/GAGCAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SUPT16H (21819631 - 21852425 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SUPT16H: --

    Human Gene Mutation Database (HGMD): SUPT16H
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605012    OMIM disorders: --

    2 diseases for SUPT16H:    About MalaCards
    williams syndrome    breast cancer


    SUPT16H for disorders           About GeneDecksing


    Export disorders for SUPT16H gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUPT16H gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with SUPT16H)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. (PubMed id 11239457)1, 2, 3 Keller D.M....Lu H. (2001)
    2. FACT, a factor that facilitates transcript elongation through nucleosomes. (PubMed id 9489704)1, 2, 3 Orphanides G.... Reinberg D. (1998)
    3. FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. (PubMed id 10912001)1, 2, 9 Wada T.... Handa H. (2000)
    4. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. (PubMed id 10421373)1, 2, 9 Orphanides G.... Reinberg D. (1999)
    5. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Modulation of nucleosome-binding activity of FACT by poly(ADP- ribosyl)ation. (PubMed id 16682447)1, 2 Huang J.-Y....Lee S.-C. (2006)
    8. Nek9, a novel FACT-associated protein, modulates interphase progression. (PubMed id 14660563)1, 2 Tan B.C.-M. and Lee S.-C. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. FACT facilitates transcription-dependent nucleosome alteration. (PubMed id 12934006)1, 2 Belotserkovskaya R.... Reinberg D. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11198 HGNC: 11465 AceView: SUPT16H Ensembl:ENSG00000092201 euGenes: HUgn11198
    ECgene: SUPT16H H-InvDB: SUPT16H

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUPT16H Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUPT16H gene:
    Search GeneIP for patents involving SUPT16H

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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