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SUOX Gene

protein-coding   GIFtS: 66
GCID: GC12P056391

Sulfite Oxidase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sulfite Oxidase1 2
EC 1.8.3.13 8
Sulfite Oxidase, Mitochondrial2

External Ids:    HGNC: 114601   Entrez Gene: 68212   Ensembl: ENSG000001395317   OMIM: 6068875   UniProtKB: P516873   

Export aliases for SUOX gene to outside databases

Previous GC identifers: GC12M056183 GC12P056958 GC12P056107 GC12P054681 GC12P054651 GC12P054677 GC12P053429


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SUOX Gene:
Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit
contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to
sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine.
Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age.
Alternative splicing results in multiple transcript variants encoding identical proteins. (provided by RefSeq,
Jul 2008)

GeneCards Summary for SUOX Gene:
SUOX (sulfite oxidase) is a protein-coding gene. Diseases associated with SUOX include sulfite oxidase deficiency, and encephalomalacia. GO annotations related to this gene include electron carrier activity and molybdopterin cofactor binding.

Gene Wiki entry for SUOX (Sulfite oxidase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUOX gene promoter:
         STAT1   HTF   Olf-1   STAT1beta   STAT1alpha   C/EBPalpha   PPAR-gamma1   ARP-1   ZIC2/Zic2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUOX promoter sequence
   Search Chromatin IP Primers for SUOX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.13

SUOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUOX gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056391:  view genomic region     (about GC identifiers)

Start:
56,390,964 bp from pter      End:
56,400,425 bp from pter
Size:
9,462 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SUOX_HUMAN, P51687 (See protein sequence)
Recommended Name: Sulfite oxidase, mitochondrial precursor  
Size: 545 amino acids; 60283 Da
Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group non-covalently per subunit
Cofactor: Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit (By similarity)
Subunit: Homodimer (By similarity)
Sequence caution: Sequence=AAA74886.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAL08048.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for SUOX:
1MJ4 (3D)    

Explore the universe of human proteins at neXtProt for SUOX: NX_P51687

Explore proteomics data for SUOX at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SUOX (P51687) (see all 7)
     RVVVPGV  GAISTARW  GYAWSGGGR  VLLAYEMNG 


    See SUOX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000447.2  NP_001027558.1  NP_001027559.1  

    ENSEMBL proteins: 
     ENSP00000348440   ENSP00000266971   ENSP00000377674   ENSP00000448637   ENSP00000450049  
     ENSP00000450245   ENSP00000449872   ENSP00000449443   ENSP00000377668   ENSP00000450264  
    Reactome Protein details: P51687

    SUOX Human Recombinant Protein Products:

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    Novus Biologicals SUOX Proteins
    Novus Biologicals SUOX Lysates
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    Cloud-Clone Corp. Proteins for SUOX

    SUOX Antibody Products:

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    SUOX Assay Products:

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    Cloud-Clone Corp. CLIAs for SUOX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR018506 Cyt_B5_heme-BS
     IPR014756 Ig_E-set
     IPR001199 Cyt_B5-like_heme/steroid-bd
     IPR000572 OxRdtase_Mopterin-bd_dom
     IPR022407 OxRdtase_Mopterin_BS

    Graphical View of Domain Structure for InterPro Entry P51687

    ProtoNet protein and cluster: P51687

    2 Blocks protein domains:
    IPB001199 Cytochrome b5
    IPB008335 Eukaryotic molybdopterin domain signature


    UniProtKB/Swiss-Prot: SUOX_HUMAN, P51687
    Similarity: Contains 1 cytochrome b5 heme-binding domain


    SUOX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUOX_HUMAN, P51687
    Catalytic activity: Sulfite + O(2) + H(2)O = sulfate + H(2)O(2)

         Enzyme Number (IUBMB): EC 1.8.3.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008482sulfite oxidase activity TAS--
    GO:0009055electron carrier activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0020037heme binding IEA--
    GO:0030151molybdenum ion binding IEA--
         
    SUOX for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SUOX:
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUOX
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUOX

    miRNA
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    miRTarBase miRNAs that target SUOX:
    hsa-mir-17-5p (MIRT051024)

    Block miRNA regulation of human, mouse, rat SUOX using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate SUOX:
    hsa-miR-146a* hsa-miR-548n hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidSUOX 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SUOX

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    GenScript: all cDNA clones in your preferred vector (see all 3): SUOX (NM_000456)
    Sino Biological Human cDNA Clone for SUOX
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUOX

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUOX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SUOX_HUMAN, P51687: Mitochondrion intermembrane space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    peroxisome2
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005758mitochondrial intermembrane space IEA--
    GO:0005759mitochondrial matrix TAS--

    SUOX for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SUOX About    
    See pathways by source

    SuperPathContained pathways About
    1Sulfur amino acid metabolism
    Sulfur amino acid metabolism0.35
    sulfite oxidation IV0.00
    Degradation of cysteine and homocysteine0.00
    Sulfide oxidation to sulfate0.00
    2Metabolism
    Metabolism0.38
    3superpathway of methionine degradation
    superpathway of methionine degradation
    4Sulfur metabolism
    Sulfur metabolism
    5Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SUOX
        sulfite oxidation IV
    superpathway of methionine degradation


    1 Reactome Pathway for SUOX
        Sulfide oxidation to sulfate


    1 Kegg Pathway  (Kegg details for SUOX):
        Sulfur metabolism

    UniProtKB/Swiss-Prot: SUOX_HUMAN, P51687
    Pathway: Energy metabolism; sulfur metabolism


    SUOX for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SUOX
    Interactions:

        Search GeneGlobe Interaction Network for SUOX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for SUOX (P516873 ENSP000002669714) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    TNFRSF11AQ9Y6Q63I2D: score=1 
    PAPSS1ENSP000002651744STRING: ENSP00000265174
    PAPSS2ENSP000004061574STRING: ENSP00000406157
    ETHE1ENSP000002921474STRING: ENSP00000292147
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0000098sulfur amino acid catabolic process TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process ----

    SUOX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUOX

    7 HMDB Compounds for SUOX    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    MolybdenumMo (see all 7)7439-98-7--
    OxygenOxygen (see all 5)7782-44-7--
    SulfateSulfate (ion 2-) (see all 9)14808-79-8--
    SulfiteSulfite ion (see all 10)14265-45-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for SUOX    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (Molybdopterin-S,S)-Dioxo-Thio-Molybdenum(V)-- --target--17139284 17016423 10592235
    Heme-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for SUOX gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    molybdenum 93.3 51 11185564 (4), 12533804 (3), 16784786 (3), 15606194 (2) (see all 37)
    s-sulfocysteine 90.2 2 20385644 (1), 15952210 (1)
    moco 85.8 6 12832761 (2), 11042213 (2), 18411266 (1)
    molybdopterin 84.7 15 11042213 (2), 15952210 (2), 18959753 (1), 16229463 (1) (see all 5)
    xanthine 78.7 30 15732969 (2), 14989655 (2), 9634514 (1), 12385777 (1) (see all 23)
    pterin 74.7 1 18096847 (1)
    sulfate 71.8 15 14514920 (2), 18842692 (1), 14729666 (1), 15329822 (1) (see all 11)
    endor 64.4 1 1850296 (1)
    ferricyanide 62.5 1 12526484 (1)
    flavin semiquinone 61.6 1 8241137 (1)



    SUOX for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SUOX gene (3 alternative transcripts): 
    NM_000456.2  NM_001032386.1  NM_001032387.1  

    Unigene Cluster for SUOX:

    Sulfite oxidase
    Hs.558403  [show with all ESTs]
    Unigene Representative Sequence: BX647356
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356124(uc001siz.3) ENST00000266971(uc001siy.3) ENST00000550121
    ENST00000552363 ENST00000551698 ENST00000550340 ENST00000394115(uc001six.3)
    ENST00000547586 ENST00000552258 ENST00000548274 ENST00000552813(uc009zoh.3)
    ENST00000550478 ENST00000546833 ENST00000551841 ENST00000394109(uc001sja.3)
    ENST00000546712 ENST00000550065
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate SUOX:
    hsa-miR-146a* hsa-miR-548n hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidSUOX 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): SUOX (NM_000456)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUOX
    Primer
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    OriGene qPCR primer pairs and template standards for SUOX
    OriGene qSTAR qPCR primer pairs in human, mouse for SUOX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SUOX
      QuantiTect SYBR Green Assays in human, mouse, rat SUOX
      QuantiFast Probe-based Assays in human, mouse, rat SUOX

    Additional mRNA sequence: 

    AK309669.1 AK312763.1 BC065193.1 BX647356.1 HM013717.1 L31573.1 

    16 DOTS entries:

    DT.100699185  DT.100785385  DT.315435  DT.101976842  DT.121188798  DT.121188807  DT.91726641  DT.100654291 
    DT.100785379  DT.100785384  DT.121188806  DT.100643817  DT.121188791  DT.75194469  DT.100683225  DT.91777995 

    Selected AceView cDNA sequences (see all 137):

    BQ230958 AA429272 T87171 BM737664 CR610752 BC065193 AW295774 AA937906 
    BF970683 BM790728 BQ218422 BF195850 AI263796 AU121557 BX424964 BM930784 
    CD105857 AU126450 BM765253 AA737021 BM764484 AI081827 BU736694 CB241407 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SUOX (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f ·
    SP1:                                                        -           -     -     -     -                             -                                       
    SP2:                                                        -     -     -     -     -     -                             -                                       
    SP3:                                                              -     -     -     -     -                                                                     
    SP4:                                                              -     -     -     -     -                                                                     
    SP5:                                                  -     -           -     -     -     -                             -                                       

    ExUns: 9g · 9h · 9i · 9j ^ 10a · 10b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for SUOX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SUOX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAGAAAA
    SUOX Expression
    About this image


    SUOX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
    SUOX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUOX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558403
        Custom PCR Arrays for SUOX
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SUOX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUOX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUOX gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Suox1 , 5 sulfite oxidase1, 5 85.5(n)1
    85.69(a)1
      10 (77.12 cM)5
    2113891  NM_173733.31  NP_776094.21 
     1286698875 
    lizard
    (Anolis carolinensis)
    Reptilia SUOX6
    sulfite oxidase
    63(a)
    1 ↔ 1
    GL343198.1(3449819-3453644)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia suox1 sulfite oxidase 61.13(n)
    60.63(a)
      100145725  NM_001127099.1  NP_001120571.1 
    zebrafish
    (Danio rerio)
    Actinopterygii suox1 sulfite oxidase 60.92(n)
    63.29(a)
      566675  XM_005172813.1  XP_005172870.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72801 , 3 protein catabolism sulfite oxidase3
    CG72801
    52(a)3
    56.22(n)1
    53.86(a)1
      17E63
    328781  NM_133103.21  NP_573331.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H13N06.43
    suox-11
    Heme-binding domain in cytochrome b5
    and oxidoreductases, more3
    suox-11
    48(a)3
    54.73(n)1
    50.22(a)1
      X(15532780-15535307)3
    1816381  NM_001029564.31  NP_001024735.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SOX1 SOX 52.9(n)
    47.28(a)
      820118  NM_111057.3  NP_186840.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g05304001 Os08g0530400 54.14(n)
    48.07(a)
      4346125  NM_001068861.1  NP_001062326.1 


    ENSEMBL Gene Tree for SUOX (if available)
    TreeFam Gene Tree for SUOX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUOX gene
    2 SIMAP similar genes for SUOX using alignment to 7 protein entries:     SUOX_HUMAN (see all proteins):
    DKFZp686M0619    CYB5B

    SUOX for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SUOX
    PGOHUM00000249411


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SUOX (see all 246)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0157304
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0157302 W R mis40--------
    VAR_0022024
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0022022 S Y mis40--------
    VAR_0022034
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0022032 G D mis40--------
    VAR_0157254
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0157252 R Q mis40--------
    VAR_0157294
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0157292 Q R mis40--------
    VAR_0157264
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0157262 G S mis40--------
    VAR_0157284
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0157282 K R mis40--------
    VAR_0022004
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0022002 R Q mis40--------
    VAR_0157274
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0157272 R H mis40--------
    VAR_0022014
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0022012 A D mis40--------

    HapMap Linkage Disequilibrium report for SUOX (56390964 - 56400425 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SUOX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832427CNV Loss17160897
    nsv832424CNV Loss17160897

    Human Gene Mutation Database (HGMD): SUOX
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUOX
    DNA2.0 Custom Variant and Variant Library Synthesis for SUOX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606887   
    OMIM disorders: 272300  
    UniProtKB/Swiss-Prot: SUOX_HUMAN, P51687
  • Isolated sulfite oxidase deficiency (ISOD) [MIM:272300]: Characterized by neurological abnormalities
    including multicystic leukoencephalopathy with brain atrophy. Patients often suffer from seizures. Often leads to
    death at an early age. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for SUOX (see all 28):    
    About MalaCards
    sulfite oxidase deficiency    encephalomalacia    hereditary fructose intolerance syndrome    serine deficiency
    lens subluxation    glycine encephalopathy    molybdenum cofactor deficiency    weill-marchesani syndrome
    homocystinuria    primary biliary cirrhosis    metabolic acidosis    intellectual disability
    alopecia areata    amyloidosis    polycystic ovary syndrome    fanconi's anemia
    alopecia    vitiligo    lymphoblastic leukemia    type 1 diabetes

    5 diseases from the University of Copenhagen DISEASES database for SUOX:
    Hereditary fructose intolerance syndrome     Serine deficiency     Lens subluxation     Encephalomalacia
    Glycine encephalopathy

    SUOX for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SUOX gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sulfite oxidase deficiency 98.8 66 17940249 (6), 16140720 (6), 10519592 (5), 11825068 (5) (see all 29)
    molybdenum cofactor deficiency 94.5 16 12533804 (3), 9634514 (1), 12385777 (1), 20385644 (1) (see all 10)
    xanthinuria, type i 85.9 2 20385644 (1), 2289312 (1)
    ectopia lentis 76.8 1 9541430 (1)
    lens dislocation 67.7 1 9415683 (1)
    encephalomalacia 57 2 16970890 (1), 16140720 (1)
    homocystinuria 42.6 2 1404882 (1), 9541430 (1)
    brain atrophy 34 1 16140720 (1)
    metabolic disorder 30.4 3 19544009 (1), 20385644 (1)
    developmental delay 26.3 1 2289312 (1)

    Genetic Association Database (GAD): SUOX
    Human Genome Epidemiology (HuGE) Navigator: SUOX (3 documents)

    Export disorders for SUOX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUOX gene, integrated from 10 sources (see all 147):
    (articles sorted by number of sources associating them with SUOX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human liver sulfite oxidase. (PubMed id 7599189)1, 2, 3, 9 Garrett R.M.... Rajagopalan K.V. (Biochim. Biophys. Acta 1995)
    2. Isolated sulfite oxidase deficiency: review of two cases in one family. (PubMed id 10519592)1, 2, 9 Edwards M.C.... MacDonald I.M. (Ophthalmology 1999)
    3. Human sulfite oxidase R160Q: identification of the mutation in a sulfite oxidase-deficient patient and expression and characterization of the mutant enzyme. (PubMed id 9600976)1, 2, 9 Garrett R.M....Rajagopalan K.V. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    4. The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain. (PubMed id 12832761)1, 2, 9 Rudolph M.J.... Kisker C. (Acta Crystallogr. D 2003)
    5. Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada. (PubMed id 17366837)1, 4, 9 Steinberg K.K....Satten G.A. (Environ. Health Perspect. 2007)
    6. A novel mutation in neonatal isolated sulphite oxidase deficiency. (PubMed id 12368985)1, 2, 9 Lee H.F.... Shu S.G. (Neuropediatrics 2002)
    7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    8. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. (PubMed id 18198356)1, 4 Hakonarson H....Polychronakos C. (Diabetes 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Isolated sulfite oxidase deficiency: identification of 12 novel SUOX mutations in 10 patients. (PubMed id 12112661)1, 2 Johnson J.L.... Rajagopalan K.V. (Hum. Mutat. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6821 HGNC: 11460 AceView: SUOX Ensembl:ENSG00000139531 euGenes: HUgn6821
    ECgene: SUOX Kegg: 6821 H-InvDB: SUOX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SUOX Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=SUOX[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SUOX gene:
    Search GeneIP for patents involving SUOX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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