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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUOX Gene

protein-coding   GIFtS: 66
GCID: GC12P056391

Sulfite Oxidase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sulfite Oxidase1 2
EC 1.8.3.13 8
Sulfite Oxidase, Mitochondrial2

External Ids:    HGNC: 114601   Entrez Gene: 68212   Ensembl: ENSG000001395317   OMIM: 6068875   UniProtKB: P516873   

Export aliases for SUOX gene to outside databases

Previous GC identifers: GC12M056183 GC12P056958 GC12P056107 GC12P054681 GC12P054651 GC12P054677 GC12P053429


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUOX Gene:
Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit
contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to
sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine.
Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age.
Alternative splicing results in multiple transcript variants encoding identical proteins. (provided by RefSeq,
Jul 2008)

GeneCards Summary for SUOX Gene: 
SUOX (sulfite oxidase) is a protein-coding gene. Diseases associated with SUOX include sulfite oxidase deficiency, and encephalomalacia, and among its related super-pathways are Sulfide oxidation to sulfate and Metabolic pathways. GO annotations related to this gene include electron carrier activity and molybdopterin cofactor binding.

Gene Wiki entry for SUOX (Sulfite oxidase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUOX gene promoter:
         STAT1   HTF   Olf-1   STAT1beta   STAT1alpha   C/EBPalpha   PPAR-gamma1   ARP-1   ZIC2/Zic2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUOX promoter sequence
   Search SABiosciences Chromatin IP Primers for SUOX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.13

SUOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUOX gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056391:  view genomic region     (about GC identifiers)

Start:
56,390,964 bp from pter      End:
56,400,425 bp from pter
Size:
9,462 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SUOX_HUMAN, P51687 (See protein sequence)
Recommended Name: Sulfite oxidase, mitochondrial precursor  
Size: 545 amino acids; 60283 Da
Cofactor: Binds 1 protoheme group
Cofactor: Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit (By similarity)
Subunit: Homodimer (By similarity)
Subcellular location: Mitochondrion intermembrane space
Sequence caution: Sequence=AAA74886.1; Type=Erroneous initiation; Sequence=AAL08048.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SUOX:
1MJ4 (3D)    

Explore the universe of human proteins at neXtProt for SUOX: NX_P51687

Explore proteomics data for SUOX at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51687

  • 4/7 DME Specific Peptides for SUOX (P51687) (see all 7)
     RVVVPGV  GAISTARW  GYAWSGGGR  VLLAYEMNG 

    SUOX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SUOX Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000447.2  NP_001027558.1  NP_001027559.1  

    ENSEMBL proteins: 
     ENSP00000348440   ENSP00000266971   ENSP00000377674   ENSP00000448637   ENSP00000450049  
     ENSP00000450245   ENSP00000449872   ENSP00000449443   ENSP00000377668   ENSP00000450264  
    Reactome Protein details: P51687
    Human Recombinant Protein Products for SUOX: 
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    Novus Biologicals SUOX Proteins
    Novus Biologicals SUOX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUOX 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005758mitochondrial intermembrane space IEA--
    GO:0005759mitochondrial matrix TAS--

    SUOX for ontologies           About GeneDecksing



    SUOX Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SUOX 

    Assay Products for SUOX: 
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    Cloud-Clone Corp. ELISAs for SUOX 
    Cloud-Clone Corp. CLIAs for SUOX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR018506 Cyt_B5_heme-BS
     IPR014756 Ig_E-set
     IPR001199 Cyt_B5-like_heme/steroid-bd
     IPR000572 OxRdtase_Mopterin-bd_dom
     IPR022407 OxRdtase_Mopterin_BS

    Graphical View of Domain Structure for InterPro Entry P51687

    ProtoNet protein and cluster: P51687

    2 Blocks protein domains:
    IPB001199 Cytochrome b5
    IPB008335 Eukaryotic molybdopterin domain signature


    UniProtKB/Swiss-Prot: SUOX_HUMAN, P51687
    Similarity: Contains 1 cytochrome b5 heme-binding domain


    SUOX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUOX_HUMAN, P51687
    Catalytic activity: Sulfite + O(2) + H(2)O = sulfate + H(2)O(2)

         Enzyme Number (IUBMB): EC 1.8.3.11 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008482sulfite oxidase activity TAS--
    GO:0009055electron carrier activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0020037heme binding IEA--
    GO:0030151molybdenum ion binding IEA--
         
    SUOX for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SUOX:
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SUOX 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUOX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUOX 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUOX 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUOX
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate SUOX:
    hsa-miR-146a* hsa-miR-548n hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidSUOX 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUOX


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SUOX About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Degradation of cysteine and homocysteine
    Degradation of cysteine and homocysteine0.62
    Sulfide oxidation to sulfate0.62
    2Metabolism
    Metabolism0.40
    3Cysteine and methionine metabolism
    Sulfur amino acid metabolism0.37
    42-oxobutanoate degradation I
    superpathway of methionine degradation0.37
    5sulfite oxidation IV
    sulfite oxidation IV

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SUOX
        sulfite oxidation IV
    superpathway of methionine degradation

    5        Reactome Pathways for SUOX
        Sulfide oxidation to sulfate
    Metabolism
    Sulfur amino acid metabolism
    Degradation of cysteine and homocysteine
    Metabolism of amino acids and derivatives


    1         Kegg Pathway  (Kegg details for SUOX):
        Sulfur metabolism

    UniProtKB/Swiss-Prot: SUOX_HUMAN, P51687
    Pathway: Energy metabolism; sulfur metabolism


    SUOX for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SUOX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for SUOX (P516873 ENSP000002669714) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF11AQ9Y6Q63, ENSP000002694854I2D: score=1 STRING: ENSP00000269485
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ETHE1ENSP000002921474STRING: ENSP00000292147
    PAPSS1ENSP000002651744STRING: ENSP00000265174
    PAPSS2ENSP000004061574STRING: ENSP00000406157
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0000098sulfur amino acid catabolic process TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process ----

    SUOX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SUOX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUOX

    7 HMDB Compounds for SUOX    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    MolybdenumMo (see all 7)7439-98-7--
    OxygenOxygen (see all 5)7782-44-7--
    SulfateSulfate (ion 2-) (see all 9)14808-79-8--
    SulfiteSulfite ion (see all 10)14265-45-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for SUOX    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (Molybdopterin-S,S)-Dioxo-Thio-Molybdenum(V)-- --target--17139284 17016423 10592235
    Heme-- --target--10592235

    10/34 Novoseek inferred chemical compound relationships for SUOX gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    molybdenum 93.3 51 11185564 (4), 12533804 (3), 16784786 (3), 15606194 (2) (see all 37)
    s-sulfocysteine 90.2 2 20385644 (1), 15952210 (1)
    moco 85.8 6 12832761 (2), 11042213 (2), 18411266 (1)
    molybdopterin 84.7 15 11042213 (2), 15952210 (2), 18959753 (1), 16229463 (1) (see all 5)
    xanthine 78.7 30 15732969 (2), 14989655 (2), 9634514 (1), 12385777 (1) (see all 23)
    pterin 74.7 1 18096847 (1)
    sulfate 71.8 15 14514920 (2), 18842692 (1), 14729666 (1), 15329822 (1) (see all 11)
    endor 64.4 1 1850296 (1)
    ferricyanide 62.5 1 12526484 (1)
    flavin semiquinone 61.6 1 8241137 (1)

    Search CenterWatch for drugs/clinical trials and news about SUOX

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUOX gene (3 alternative transcripts): 
    NM_000456.2  NM_001032386.1  NM_001032387.1  

    Unigene Cluster for SUOX:

    Sulfite oxidase
    Hs.558403  [show with all ESTs]
    Unigene Representative Sequence: BX647356
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356124(uc001siz.3) ENST00000266971(uc001siy.3) ENST00000550121
    ENST00000552363 ENST00000551698 ENST00000550340 ENST00000394115(uc001six.3)
    ENST00000547586 ENST00000552258 ENST00000548274 ENST00000552813(uc009zoh.3)
    ENST00000550478 ENST00000546833 ENST00000551841 ENST00000394109(uc001sja.3)
    ENST00000546712 ENST00000550065
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate SUOX:
    hsa-miR-146a* hsa-miR-548n hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidSUOX 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK309669.1 AK312763.1 BC065193.1 BX647356.1 HM013717.1 L31573.1 

    16 DOTS entries:

    DT.100699185  DT.100785385  DT.315435  DT.101976842  DT.121188798  DT.121188807  DT.91726641  DT.100654291 
    DT.100785379  DT.100785384  DT.121188806  DT.100643817  DT.121188791  DT.75194469  DT.100683225  DT.91777995 

    24/137 AceView cDNA sequences (see all 137):

    CR610752 AU126450 BQ218422 AA429272 AA725164 AI081827 BC065193 BM790728 
    AU121557 AA937906 BM737664 AI269953 BM829872 BM757373 BM930784 CB140968 
    BU736694 BM740663 BM764484 BX424964 BM772026 BF970683 BM765253 AA368248 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for SUOX (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f ·
    SP1:                                                        -           -     -     -     -                             -                                       
    SP2:                                                        -     -     -     -     -     -                             -                                       
    SP3:                                                              -     -     -     -     -                                                                     
    SP4:                                                              -     -     -     -     -                                                                     
    SP5:                                                  -     -           -     -     -     -                             -                                       

    ExUns: 9g · 9h · 9i · 9j ^ 10a · 10b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for SUOX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUOX expression in normal human tissues (normalized intensities)      SUOX embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAGAAAA
    SUOX Expression
    About this image


    SUOX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See SUOX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUOX

    SOURCE GeneReport for Unigene cluster: Hs.558403
        SABiosciences Custom PCR Arrays for SUOX
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUOX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUOX gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Suox1 , 5 sulfite oxidase1, 5 85.5(n)1
    85.69(a)1
      10 (77.12 cM)5
    2113891  NM_173733.31  NP_776094.21 
     1286698875 
    lizard
    (Anolis carolinensis)
    Reptilia SUOX6
    Uncharacterized protein
    63(a)
    1 ↔ 1
    GL343198.1(3449819-3453644)
    zebrafish
    (Danio rerio)
    Actinopterygii SUOX6
    sulfite oxidase
    54(a)
    1 ↔ 1
    11(3327408-3341650)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72801 , 3 protein catabolism sulfite oxidase3
    CG72801
    52(a)3
    56.22(n)1
    53.86(a)1
      17E63
    328781  NM_133103.21  NP_573331.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H13N06.43
    suox-11
    Heme-binding domain in cytochrome b5
    and oxidoreductases, more3
    Protein SUOX-11
    48(a)3
    55(n)1
    50.33(a)1
      X(15532780-15535307)3
    1816381  NM_001029564.21  NP_001024735.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SOX1 sulfite oxidase 52.9(n)
    47.28(a)
      820118  NM_111057.3  NP_186840.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g05304001 hypothetical protein 53.15(n)
    47.03(a)
      4346125  NM_001068861.1  NP_001062326.1 


    ENSEMBL Gene Tree for SUOX (if available)
    TreeFam Gene Tree for SUOX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUOX gene
    2 SIMAP similar genes for SUOX using alignment to 7 protein entries:     SUOX_HUMAN (see all proteins):
    DKFZp686M0619    CYB5B

    SUOX for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SUOX
    PGOHUM00000249411


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/246 SNPs in SUOX are shown (see all 246)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0157304
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0157302 W R mis40--------
    VAR_0022024
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0022022 S Y mis40--------
    VAR_0022034
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0022032 G D mis40--------
    VAR_0157254
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0157252 R Q mis40--------
    VAR_0157294
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0157292 Q R mis40--------
    VAR_0157264
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0157262 G S mis40--------
    VAR_0157284
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0157282 K R mis40--------
    VAR_0022004
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0022002 R Q mis40--------
    VAR_0157274
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0157272 R H mis40--------
    VAR_0022014
    Isolated sulfite oxidase deficiency (ISOD)4--see VAR_0022012 A D mis40--------

    HapMap Linkage Disequilibrium report for SUOX (56390964 - 56400425 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SUOX:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832427CNV Loss17160897
    nsv832424CNV Loss17160897


    Human Gene Mutation Database (HGMD): SUOX
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SUOX
    DNA2.0 Custom Variant and Variant Library Synthesis for SUOX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606887   
    OMIM disorders: 272300  
    UniProtKB/Swiss-Prot: SUOX_HUMAN, P51687
  • Isolated sulfite oxidase deficiency (ISOD) [MIM:272300]: Characterized by neurological abnormalities
    including multicystic leukoencephalopathy with brain atrophy. Patients often suffer from seizures. Often leads to
    death at an early age. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20 diseases for SUOX:    About MalaCards
    sulfite oxidase deficiency    encephalomalacia    lens subluxation    molybdenum cofactor deficiency
    weill-marchesani syndrome    homocystinuria    metabolic disorders    primary biliary cirrhosis
    metabolic acidosis    intellectual disability    amyloidosis    fanconi's anemia
    acute lymphoblastic leukemia    polycystic ovary syndrome    lymphoblastic leukemia    mental retardation
    anemia    type 1 diabetes    leukemia    hepatitis

    5 diseases from the University of Copenhagen DISEASES database for SUOX:
    Hereditary fructose intolerance syndrome     Serine deficiency     Lens subluxation     Encephalomalacia
    Glycine encephalopathy

    SUOX for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for SUOX gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sulfite oxidase deficiency 98.8 66 17940249 (6), 16140720 (6), 10519592 (5), 11825068 (5) (see all 29)
    molybdenum cofactor deficiency 94.5 16 12533804 (3), 9634514 (1), 12385777 (1), 20385644 (1) (see all 10)
    xanthinuria, type i 85.9 2 20385644 (1), 2289312 (1)
    ectopia lentis 76.8 1 9541430 (1)
    lens dislocation 67.7 1 9415683 (1)
    encephalomalacia 57 2 16970890 (1), 16140720 (1)
    homocystinuria 42.6 2 1404882 (1), 9541430 (1)
    brain atrophy 34 1 16140720 (1)
    metabolic disorder 30.4 3 19544009 (1), 20385644 (1)
    developmental delay 26.3 1 2289312 (1)

    Genetic Association Database (GAD): SUOX
    Human Genome Epidemiology (HuGE) Navigator: SUOX (3 documents)

    Export disorders for SUOX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUOX gene, integrated from 9 sources (see all 147):
    (articles sorted by number of sources associating them with SUOX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human liver sulfite oxidase. (PubMed id 7599189)1, 2, 3, 9 Garrett R.M.... Rajagopalan K.V. (1995)
    2. Isolated sulfite oxidase deficiency: review of two cases in one family. (PubMed id 10519592)1, 2, 9 Edwards M.C.... MacDonald I.M. (1999)
    3. Human sulfite oxidase R160Q: identification of the mutation in a sulfite oxidase-deficient patient and expression and characterization of the mutant enzyme. (PubMed id 9600976)1, 2, 9 Garrett R.M....Rajagopalan K.V. (1998)
    4. The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain. (PubMed id 12832761)1, 2, 9 Rudolph M.J.... Kisker C. (2003)
    5. Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada. (PubMed id 17366837)1, 4, 9 Steinberg K.K....Satten G.A. (2007)
    6. A novel mutation in neonatal isolated sulphite oxidase deficiency. (PubMed id 12368985)1, 2, 9 Lee H.F.... Shu S.G. (2002)
    7. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    8. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. (PubMed id 18198356)1, 4 Hakonarson H....Polychronakos C. (2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Isolated sulfite oxidase deficiency: identification of 12 novel SUOX mutations in 10 patients. (PubMed id 12112661)1, 2 Johnson J.L.... Rajagopalan K.V. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6821 HGNC: 11460 AceView: SUOX Ensembl:ENSG00000139531 euGenes: HUgn6821
    ECgene: SUOX Kegg: 6821 H-InvDB: SUOX

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUOX Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SUOX

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUOX gene:
    Search GeneIP for patents involving SUOX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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