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Aliases for SUN5 Gene

Aliases for SUN5 Gene

  • Sad1 And UNC84 Domain Containing 5 2 3
  • SPAG4L 3 4 6
  • TSARG4 3 4 6
  • Testis And Spermatogenesis-Related Gene 4 Protein 3 4
  • Sad1 And UNC84 Domain-Containing Protein 5 3 4
  • Testis And Spermatogenesis Related Gene 4 2 3
  • Sperm-Associated Antigen 4-Like Protein 3 4
  • Sperm Associated Antigen 4-Like 2
  • SUN Domain-Containing Protein 5 3
  • DJ726C3.1 3

External Ids for SUN5 Gene

Previous Symbols for SUN5 Gene

  • SPAG4L

Summaries for SUN5 Gene

GeneCards Summary for SUN5 Gene

SUN5 (Sad1 And UNC84 Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is SUN1.

Gene Wiki entry for SUN5 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUN5 Gene

Genomics for SUN5 Gene

Genomic Location for SUN5 Gene

32,983,773 bp from pter
33,004,433 bp from pter
20,661 bases
Minus strand

Genomic View for SUN5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUN5 Gene

No data available for Regulatory Elements for SUN5 Gene

Proteins for SUN5 Gene

  • Protein details for SUN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SUN domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • A6NJ82
    • Q5T9R0

    Protein attributes for SUN5 Gene

    379 amino acids
    Molecular mass:
    43081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SUN5 Gene

Proteomics data for SUN5 Gene at MOPED

Post-translational modifications for SUN5 Gene

No Post-translational modifications

Other Protein References for SUN5 Gene

No data available for DME Specific Peptides for SUN5 Gene

Domains for SUN5 Gene

Protein Domains for SUN5 Gene



  • Contains 1 SUN domain.:
    • Q8TC36
genes like me logo Genes that share domains with SUN5: view

No data available for Gene Families for SUN5 Gene

Function for SUN5 Gene

Gene Ontology (GO) - Molecular Function for SUN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SUN5: view
genes like me logo Genes that share phenotypes with SUN5: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SUN5 Gene

Localization for SUN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUN5 Gene

Nucleus inner membrane; Single-pass membrane protein. Note=Restricted to the apical nuclear region of round spermatids that face the acrosomic vesicle. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SUN5 Gene COMPARTMENTS Subcellular localization image for SUN5 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SUN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus --
GO:0005635 nuclear envelope IBA --
GO:0005637 nuclear inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SUN5: view

Pathways for SUN5 Gene

SuperPathways for SUN5 Gene

No Data Available

Interacting Proteins for SUN5 Gene

Gene Ontology (GO) - Biological Process for SUN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IBA --
GO:0007283 spermatogenesis IEP 12621555
GO:0090286 cytoskeletal anchoring at nuclear membrane IBA --
genes like me logo Genes that share ontologies with SUN5: view

No data available for Pathways by source for SUN5 Gene

Transcripts for SUN5 Gene

Unigene Clusters for SUN5 Gene

Sad1 and UNC84 domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUN5 Gene

No ASD Table

Relevant External Links for SUN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SUN5 Gene

mRNA expression in normal human tissues for SUN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUN5 Gene

This gene is overexpressed in Testis (52.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SUN5 Gene

SOURCE GeneReport for Unigene cluster for SUN5 Gene Hs.375186

mRNA Expression by UniProt/SwissProt for SUN5 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with SUN5: view

Orthologs for SUN5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SUN5 36
  • 99.56 (n)
  • 98.94 (a)
SUN5 37
  • 99 (a)
(Bos Taurus)
Mammalia SPAG4L 37
  • 81 (a)
SUN5 36
  • 86.09 (n)
  • 81.57 (a)
(Canis familiaris)
Mammalia SUN5 36
  • 85.73 (n)
  • 82.38 (a)
SUN5 37
  • 83 (a)
(Mus musculus)
Mammalia Sun5 36
  • 83.58 (n)
  • 80.65 (a)
Sun5 16
Sun5 37
  • 79 (a)
(Monodelphis domestica)
Mammalia SUN5 37
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia SUN5 37
  • 48 (a)
(Rattus norvegicus)
Mammalia Sun5 36
  • 81.99 (n)
  • 79.42 (a)
(Gallus gallus)
Aves -- 37
  • 36 (a)
-- 37
  • 41 (a)
-- 37
  • 37 (a)
-- 37
  • 35 (a)
-- 37
  • 27 (a)
-- 37
  • 41 (a)
-- 37
  • 24 (a)
-- 37
  • 31 (a)
-- 37
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta koi 37
  • 15 (a)
(Caenorhabditis elegans)
Secernentea unc-84 37
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 25 (a)
Species with no ortholog for SUN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SUN5 Gene

Gene Tree for SUN5 (if available)
Gene Tree for SUN5 (if available)

Paralogs for SUN5 Gene

Paralogs for SUN5 Gene

Selected SIMAP similar genes for SUN5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SUN5: view

Variants for SUN5 Gene

Sequence variations from dbSNP and Humsavar for SUN5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs15850 -- 32,999,987(+) GTGGC(A/G)GTGCA intron-variant
rs190097 -- 32,997,609(+) TCAGC(C/T)GTGGG intron-variant, upstream-variant-2KB
rs190098 -- 32,999,790(+) TGTGC(A/G)AGGTG intron-variant
rs221971 -- 32,989,245(+) GACTG(C/T)GGGTT intron-variant
rs221972 -- 32,992,051(+) tttgc(A/G)aattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUN5 Gene

Variant ID Type Subtype PubMed ID
dgv1325e1 CNV Complex 17122850
nsv912840 CNV Loss 21882294
esv991017 CNV Deletion 20482838
essv2996 CNV CNV 17122850

Relevant External Links for SUN5 Gene

HapMap Linkage Disequilibrium report

Disorders for SUN5 Gene

Relevant External Links for SUN5

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SUN5: view

No data available for UniProtKB/Swiss-Prot for SUN5 Gene

Publications for SUN5 Gene

  1. A novel testis-specific gene, SPAG4, whose product interacts specifically with outer dense fiber protein ODF27, maps to human chromosome 20q11.2. (PMID: 9691178) Tarnasky H. … van der Hoorn F.A. (Cytogenet. Cell Genet. 1998) 2 3
  2. Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme. (PMID: 10373309) Shao X. … van der Hoorn F.A. (Dev. Biol. 1999) 2 3
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Cloning of cDNA of TSARG4, a human spermatogenesis related gene. (PMID: 12621555) Xing X.W. … Lu G.X. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2003) 3 4

Products for SUN5 Gene

Sources for SUN5 Gene

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