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Aliases for SUN5 Gene

Aliases for SUN5 Gene

  • Sad1 And UNC84 Domain Containing 5 2 3 5
  • Testis And Spermatogenesis-Related Gene 4 Protein 3 4
  • Sad1 And UNC84 Domain-Containing Protein 5 3 4
  • Testis And Spermatogenesis Related Gene 4 2 3
  • Sperm-Associated Antigen 4-Like Protein 3 4
  • SPAG4L 3 4
  • TSARG4 3 4
  • Sperm Associated Antigen 4-Like 2
  • SUN Domain-Containing Protein 5 3
  • DJ726C3.1 3
  • SPGF16 3

External Ids for SUN5 Gene

Previous HGNC Symbols for SUN5 Gene

  • SPAG4L

Previous GeneCards Identifiers for SUN5 Gene

  • GC20M031571
  • GC20M028358

Summaries for SUN5 Gene

GeneCards Summary for SUN5 Gene

SUN5 (Sad1 And UNC84 Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is SPAG4.

Gene Wiki entry for SUN5 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUN5 Gene

Genomics for SUN5 Gene

Regulatory Elements for SUN5 Gene

Enhancers for SUN5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F033991 0.2 ENCODE 16.2 -989.6 -989599 4.5 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 LOC105372596 ENSG00000229188 BPIFB5P BPIFA3 ENSG00000224876 RPL12P3 SUN5 NCOA6 RPS2P1 ENSG00000272945
GH20F033400 0.4 ENCODE 16.2 -396.9 -396914 2.1 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 BPIFB5P RPL12P3 BPIFA3 ENSG00000224876 ENSG00000229188 SUN5 LOC105372596 RPS2P1 ENSG00000272945 ASIP
GH20F033684 0.2 ENCODE 16.2 -681.5 -681452 2.9 HDGF MLX WRNIP1 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 FOS SP3 ENSG00000229188 LOC105372596 BPIFB5P RPL12P3 BPIFA3 ENSG00000224876 SUN5 RPS2P1 CBFA2T2 ZNF341-AS1
GH20F032559 0.7 Ensembl ENCODE 16.2 +443.2 443186 3.7 PKNOX1 MLX ARID4B DMAP1 ZNF48 SLC30A9 GLIS2 KLF7 SP3 SP5 SUN5 BPIFB5P BPIFA3 ENSG00000224876 RPL12P3 RNU1-94P PDRG1 MYLK2 LOC149950 LOC105372591
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SUN5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUN5 Gene

32,983,773 bp from pter
33,004,449 bp from pter
20,677 bases
Minus strand

Genomic View for SUN5 Gene

Genes around SUN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUN5 Gene

Proteins for SUN5 Gene

  • Protein details for SUN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SUN domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • A6NJ82
    • Q5T9R0

    Protein attributes for SUN5 Gene

    379 amino acids
    Molecular mass:
    43081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SUN5 Gene

Post-translational modifications for SUN5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SUN5 Gene

Domains & Families for SUN5 Gene

Protein Domains for SUN5 Gene


Suggested Antigen Peptide Sequences for SUN5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SUN domain.
  • Contains 1 SUN domain.
genes like me logo Genes that share domains with SUN5: view

No data available for Gene Families for SUN5 Gene

Function for SUN5 Gene

Gene Ontology (GO) - Molecular Function for SUN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SUN5: view
genes like me logo Genes that share phenotypes with SUN5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SUN5 Gene

Localization for SUN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUN5 Gene

Nucleus inner membrane; Single-pass membrane protein. Note=Restricted to the apical nuclear region of round spermatids that face the acrosomic vesicle. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SUN5 Gene COMPARTMENTS Subcellular localization image for SUN5 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SUN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IBA --
GO:0005637 nuclear inner membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SUN5: view

Pathways & Interactions for SUN5 Gene

SuperPathways for SUN5 Gene

No Data Available

Interacting Proteins for SUN5 Gene

Gene Ontology (GO) - Biological Process for SUN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IBA --
GO:0007283 spermatogenesis IEA,IEP 12621555
GO:0090286 cytoskeletal anchoring at nuclear membrane IBA --
genes like me logo Genes that share ontologies with SUN5: view

No data available for Pathways by source and SIGNOR curated interactions for SUN5 Gene

Transcripts for SUN5 Gene

Unigene Clusters for SUN5 Gene

Sad1 and UNC84 domain containing 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUN5 Gene

No ASD Table

Relevant External Links for SUN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SUN5 Gene

mRNA expression in normal human tissues for SUN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUN5 Gene

This gene is overexpressed in Testis (x52.8).

Protein differential expression in normal tissues from HIPED for SUN5 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUN5 Gene

Protein tissue co-expression partners for SUN5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUN5 Gene:


SOURCE GeneReport for Unigene cluster for SUN5 Gene:


mRNA Expression by UniProt/SwissProt for SUN5 Gene:

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SUN5: view

Primer Products

Orthologs for SUN5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SUN5 34 35
  • 99.56 (n)
(Bos Taurus)
Mammalia SUN5 34
  • 86.09 (n)
  • 81 (a)
(Canis familiaris)
Mammalia SUN5 34 35
  • 85.73 (n)
(Mus musculus)
Mammalia Sun5 34 16 35
  • 83.58 (n)
(Rattus norvegicus)
Mammalia Sun5 34
  • 81.99 (n)
(Monodelphis domestica)
Mammalia SUN5 35
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia SUN5 35
  • 48 (a)
(Gallus gallus)
Aves -- 35
  • 41 (a)
-- 35
  • 41 (a)
-- 35
  • 37 (a)
-- 35
  • 36 (a)
-- 35
  • 35 (a)
-- 35
  • 31 (a)
-- 35
  • 30 (a)
-- 35
  • 27 (a)
-- 35
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta koi 35
  • 15 (a)
(Caenorhabditis elegans)
Secernentea unc-84 35
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
Species where no ortholog for SUN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SUN5 Gene

Gene Tree for SUN5 (if available)
Gene Tree for SUN5 (if available)

Paralogs for SUN5 Gene

Paralogs for SUN5 Gene

(5) SIMAP similar genes for SUN5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SUN5: view

Variants for SUN5 Gene

Sequence variations from dbSNP and Humsavar for SUN5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10681483 -- 32,988,606(+) TTATT(-/TATTTATT)GAGAC intron-variant
rs111442830 -- 32,989,143(+) GATGG(C/T)CTCGA intron-variant, downstream-variant-500B
rs111516221 -- 33,004,333(+) AGGAC(A/C/G/T)GTGGC upstream-variant-2KB, reference, missense
rs11167191 -- 32,998,378(+) CAGCA(A/G)AATCG intron-variant
rs11167192 -- 32,998,401(+) AGGCA(A/G)AGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUN5 Gene

Variant ID Type Subtype PubMed ID
esv2758792 CNV loss 17122850
esv991017 CNV deletion 20482838
nsv1056411 CNV loss 25217958
nsv477263 CNV novel sequence insertion 20440878

Variation tolerance for SUN5 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.25; 76.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUN5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUN5 Gene

Disorders for SUN5 Gene

Relevant External Links for SUN5

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SUN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUN5 Gene

Publications for SUN5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Cloning of cDNA of TSARG4, a human spermatogenesis related gene. (PMID: 12621555) Xing X.W. … Lu G.X. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2003) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme. (PMID: 10373309) Shao X. … van der Hoorn F.A. (Dev. Biol. 1999) 2 3 64
  5. A novel testis-specific gene, SPAG4, whose product interacts specifically with outer dense fiber protein ODF27, maps to human chromosome 20q11.2. (PMID: 9691178) Tarnasky H. … van der Hoorn F.A. (Cytogenet. Cell Genet. 1998) 2 3 64

Products for SUN5 Gene

Sources for SUN5 Gene

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