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Aliases for SUN5 Gene

Aliases for SUN5 Gene

  • Sad1 And UNC84 Domain Containing 5 2 3 5
  • Testis And Spermatogenesis-Related Gene 4 Protein 3 4
  • Sad1 And UNC84 Domain-Containing Protein 5 3 4
  • Testis And Spermatogenesis Related Gene 4 2 3
  • Sperm-Associated Antigen 4-Like Protein 3 4
  • SPAG4L 3 4
  • TSARG4 3 4
  • Sperm Associated Antigen 4-Like 2
  • DJ726C3.1 3

External Ids for SUN5 Gene

Previous HGNC Symbols for SUN5 Gene

  • SPAG4L

Previous GeneCards Identifiers for SUN5 Gene

  • GC20M031571
  • GC20M028358

Summaries for SUN5 Gene

GeneCards Summary for SUN5 Gene

SUN5 (Sad1 And UNC84 Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is SUN1.

Gene Wiki entry for SUN5 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUN5 Gene

Genomics for SUN5 Gene

Genomic Location for SUN5 Gene

Chromosome:
20
Start:
32,983,773 bp from pter
End:
33,004,449 bp from pter
Size:
20,677 bases
Orientation:
Minus strand

Genomic View for SUN5 Gene

Genes around SUN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUN5 Gene

No data available for Regulatory Elements for SUN5 Gene

Proteins for SUN5 Gene

  • Protein details for SUN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC36-SUN5_HUMAN
    Recommended name:
    SUN domain-containing protein 5
    Protein Accession:
    Q8TC36
    Secondary Accessions:
    • A6NJ82
    • Q5T9R0

    Protein attributes for SUN5 Gene

    Size:
    379 amino acids
    Molecular mass:
    43081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SUN5 Gene

Proteomics data for SUN5 Gene at MOPED

Post-translational modifications for SUN5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SUN5 Gene

No data available for DME Specific Peptides for SUN5 Gene

Domains & Families for SUN5 Gene

Protein Domains for SUN5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SUN5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TC36

UniProtKB/Swiss-Prot:

SUN5_HUMAN :
  • Contains 1 SUN domain.
Domain:
  • Contains 1 SUN domain.
genes like me logo Genes that share domains with SUN5: view

No data available for Gene Families for SUN5 Gene

Function for SUN5 Gene

Gene Ontology (GO) - Molecular Function for SUN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043495 protein anchor IBA --
genes like me logo Genes that share ontologies with SUN5: view
genes like me logo Genes that share phenotypes with SUN5: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SUN5 Gene

Localization for SUN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUN5 Gene

Nucleus inner membrane; Single-pass membrane protein. Note=Restricted to the apical nuclear region of round spermatids that face the acrosomic vesicle. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUN5 Gene COMPARTMENTS Subcellular localization image for SUN5 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SUN5 Gene

Pathways & Interactions for SUN5 Gene

SuperPathways for SUN5 Gene

No Data Available

Interacting Proteins for SUN5 Gene

Gene Ontology (GO) - Biological Process for SUN5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SUN5 Gene

Drugs & Compounds for SUN5 Gene

No Compound Related Data Available

Transcripts for SUN5 Gene

Unigene Clusters for SUN5 Gene

Sad1 and UNC84 domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUN5 Gene

No ASD Table

Relevant External Links for SUN5 Gene

GeneLoc Exon Structure for
SUN5
ECgene alternative splicing isoforms for
SUN5

Expression for SUN5 Gene

mRNA expression in normal human tissues for SUN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUN5 Gene

This gene is overexpressed in Testis (x52.8).

Protein differential expression in normal tissues from HIPED for SUN5 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUN5 Gene



SOURCE GeneReport for Unigene cluster for SUN5 Gene Hs.375186

mRNA Expression by UniProt/SwissProt for SUN5 Gene

Q8TC36-SUN5_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SUN5: view

Protein tissue co-expression partners for SUN5 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SUN5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUN5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUN5 35
  • 86.09 (n)
  • 81.57 (a)
SPAG4L 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUN5 35
  • 85.73 (n)
  • 82.38 (a)
SUN5 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sun5 35
  • 83.58 (n)
  • 80.65 (a)
Sun5 16
Sun5 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUN5 35
  • 99.56 (n)
  • 98.94 (a)
SUN5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sun5 35
  • 81.99 (n)
  • 79.42 (a)
oppossum
(Monodelphis domestica)
Mammalia SUN5 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUN5 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 36 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta koi 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-84 36
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for SUN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SUN5 Gene

ENSEMBL:
Gene Tree for SUN5 (if available)
TreeFam:
Gene Tree for SUN5 (if available)

Paralogs for SUN5 Gene

Paralogs for SUN5 Gene

(5) SIMAP similar genes for SUN5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SUN5: view

Variants for SUN5 Gene

Sequence variations from dbSNP and Humsavar for SUN5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs3746387 - 33,004,295(+) ATCTT(C/T)GAGTA upstream-variant-2KB, reference, missense
rs1133358 - 33,002,880(-) GCAGA(C/G/T)GACAC upstream-variant-2KB, reference, missense
rs17123951 - 32,995,633(+) CATGG(C/T)TTCCA reference, missense
rs35216976 - 32,997,670(-) TTTCT(A/G)TTCAC reference, missense
rs15850 -- 32,999,987(+) GTGGC(A/G)GTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUN5 Gene

Variant ID Type Subtype PubMed ID
dgv1325e1 CNV Complex 17122850
nsv912840 CNV Loss 21882294
esv991017 CNV Deletion 20482838
essv2996 CNV CNV 17122850

Variation tolerance for SUN5 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.25; 76.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUN5 Gene

HapMap Linkage Disequilibrium report
SUN5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUN5 Gene

Disorders for SUN5 Gene

Relevant External Links for SUN5

Human Genome Epidemiology (HuGE) Navigator
SUN5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUN5

No disorders were found for SUN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUN5 Gene

Publications for SUN5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme. (PMID: 10373309) Shao X. … van der Hoorn F.A. (Dev. Biol. 1999) 2 3
  3. A novel testis-specific gene, SPAG4, whose product interacts specifically with outer dense fiber protein ODF27, maps to human chromosome 20q11.2. (PMID: 9691178) Tarnasky H. … van der Hoorn F.A. (Cytogenet. Cell Genet. 1998) 2 3
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  5. SPAG4L, a novel nuclear envelope protein involved in the meiotic stage of spermatogenesis. (PMID: 21711156) Jiang X.Z. … Xing X.W. (DNA Cell Biol. 2011) 3

Products for SUN5 Gene

Sources for SUN5 Gene

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