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Aliases for SUN3 Gene

Aliases for SUN3 Gene

  • Sad1 And UNC84 Domain Containing 3 2 3 5
  • Sad1/Unc-84 Domain-Containing Protein 1 3 4
  • Sad1 And UNC84 Domain Containing 1 2 3
  • SUNC1 3 4
  • SUN Domain-Containing Protein 3 3
  • Hypothetical Protein MGC33329 3

External Ids for SUN3 Gene

Previous HGNC Symbols for SUN3 Gene

  • SUNC1

Previous GeneCards Identifiers for SUN3 Gene

  • GC07M048026
  • GC07M047912

Summaries for SUN3 Gene

GeneCards Summary for SUN3 Gene

SUN3 (Sad1 And UNC84 Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is SUN2.

UniProtKB/Swiss-Prot for SUN3 Gene

  • As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUN3 Gene

Genomics for SUN3 Gene

Regulatory Elements for SUN3 Gene

Enhancers for SUN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G048081 2 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -61.9 -61925 18.7 FOXA2 ARNT ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF207 FOS SP3 UPP1 HUS1 ENSG00000225507 PKD1L1 SUN3 ABCA13 LOC105375271
GH07G048052 1 Ensembl ENCODE 11 -24.1 -24128 1.8 JUN FOSL1 ZFHX2 ZBTB48 FOS CREM EGR2 MTA2 GFI1B BHLHE40 UPP1 SUN3 ABCA13 HUS1 C7orf57
GH07G048073 0.7 ENCODE 11.3 -45.5 -45481 1.4 JUN MAX USF2 EP300 ZIC2 RFX5 JUND GATA3 ATF3 ZNF366 SUN3 UPP1 C7orf57
GH07G048077 0.6 dbSUPER 10.6 -49.6 -49553 1.6 TAL1 MEF2D ARID1B PRDM6 PBX2 SCRT2 FOXP2 PRDM10 SP7 ZNF18 UPP1 PKD1L1 SUN3 C7orf57
GH07G047991 1.5 FANTOM5 Ensembl ENCODE 0.3 +36.9 36862 2.2 MLX ARID4B ZNF48 YY1 ZNF143 SP3 SP5 JUNB REST KAT8 UPP1 PKD1L1 HUS1 ABCA13 LOC105375270 SUN3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SUN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUN3 Gene

Chromosome:
7
Start:
47,987,148 bp from pter
End:
48,029,127 bp from pter
Size:
41,980 bases
Orientation:
Minus strand

Genomic View for SUN3 Gene

Genes around SUN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUN3 Gene

Proteins for SUN3 Gene

  • Protein details for SUN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAQ9-SUN3_HUMAN
    Recommended name:
    SUN domain-containing protein 3
    Protein Accession:
    Q8TAQ9
    Secondary Accessions:
    • A4D2F3
    • B4DXK1
    • D3DVM3
    • E7EWC8
    • Q4F965
    • Q7Z4U8

    Protein attributes for SUN3 Gene

    Size:
    357 amino acids
    Molecular mass:
    40503 Da
    Quaternary structure:
    • Self-associates. Interacts with SYNE1 and SPAG4/SUN4. Proposed to form a spermatogenesis-specific LINC complex with SYNE1 during sperm head formation possibly implicating a SUN domain-based heterotrimer with SPAG4/SUN4 associating with SYNE1.
    SequenceCaution:
    • Sequence=AAP97300.1; Type=Frameshift; Positions=233, 242; Evidence={ECO:0000305}; Sequence=EAL23808.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SUN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUN3 Gene

Post-translational modifications for SUN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SUN3 Gene

Domains & Families for SUN3 Gene

Protein Domains for SUN3 Gene

Suggested Antigen Peptide Sequences for SUN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAQ9

UniProtKB/Swiss-Prot:

SUN3_HUMAN :
  • The short coiled coil domain is proposed to be not involved in load-bearing and force transmission from the cytoskeleton but in mere nucleus anchorage instead.
Domain:
  • The short coiled coil domain is proposed to be not involved in load-bearing and force transmission from the cytoskeleton but in mere nucleus anchorage instead.
genes like me logo Genes that share domains with SUN3: view

No data available for Gene Families for SUN3 Gene

Function for SUN3 Gene

Molecular function for SUN3 Gene

UniProtKB/Swiss-Prot Function:
As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.
genes like me logo Genes that share phenotypes with SUN3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SUN3 Gene

Localization for SUN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUN3 Gene

Membrane; Single-pass membrane protein. Nucleus envelope. Nucleus inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUN3 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SUN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IBA,IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0034993 LINC complex IEA --
genes like me logo Genes that share ontologies with SUN3: view

Pathways & Interactions for SUN3 Gene

No Data Available

Interacting Proteins for SUN3 Gene

Gene Ontology (GO) - Biological Process for SUN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IBA --
GO:0090286 cytoskeletal anchoring at nuclear membrane IBA --
genes like me logo Genes that share ontologies with SUN3: view

No data available for Pathways by source and SIGNOR curated interactions for SUN3 Gene

Drugs & Compounds for SUN3 Gene

No Compound Related Data Available

Transcripts for SUN3 Gene

Unigene Clusters for SUN3 Gene

Sad1 and UNC84 domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUN3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3:

Relevant External Links for SUN3 Gene

GeneLoc Exon Structure for
SUN3
ECgene alternative splicing isoforms for
SUN3

Expression for SUN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUN3 Gene

This gene is overexpressed in Testis (x48.1).

Protein differential expression in normal tissues from HIPED for SUN3 Gene

This gene is overexpressed in Synovial fluid (36.8) and Colon muscle (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUN3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SUN3 Gene:

SUN3

SOURCE GeneReport for Unigene cluster for SUN3 Gene:

Hs.406741

Evidence on tissue expression from TISSUES for SUN3 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with SUN3: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUN3 Gene

Orthologs for SUN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUN3 34 35
  • 99.25 (n)
mouse
(Mus musculus)
Mammalia Sun3 34 16 35
  • 83.27 (n)
cow
(Bos Taurus)
Mammalia SUN3 34 35
  • 82.95 (n)
rat
(Rattus norvegicus)
Mammalia Sun3 34
  • 82.05 (n)
dog
(Canis familiaris)
Mammalia SUN3 34 35
  • 80.09 (n)
oppossum
(Monodelphis domestica)
Mammalia SUN3 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUN3 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 40 (a)
OneToMany
-- 35
  • 40 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
-- 35
  • 35 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta koi 35
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-84 35
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToMany
Species where no ortholog for SUN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SUN3 Gene

ENSEMBL:
Gene Tree for SUN3 (if available)
TreeFam:
Gene Tree for SUN3 (if available)

Paralogs for SUN3 Gene

Variants for SUN3 Gene

Sequence variations from dbSNP and Humsavar for SUN3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000014556 -- 48,024,566(+) TTGCT(A/G)TAAAG intron-variant
rs1000037577 -- 48,009,838(+) GTACC(A/G)GGCTA intron-variant
rs1000052287 -- 48,009,154(+) AAGGG(-/AAAT)AAATA intron-variant
rs1000061909 -- 48,033,625(+) TTATC(A/G)CTGAA intron-variant, upstream-variant-2KB
rs1000140707 -- 47,993,172(+) AACTG(A/T)GAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUN3 Gene

Variant ID Type Subtype PubMed ID
esv2665988 CNV deletion 23128226
esv3613065 CNV gain 21293372
esv3613073 CNV gain 21293372
esv3613076 CNV loss 21293372
nsv1128314 CNV deletion 24896259
nsv464442 CNV gain 19166990
nsv470221 CNV gain 18288195
nsv475822 CNV novel sequence insertion 20440878
nsv606893 CNV gain 21841781

Variation tolerance for SUN3 Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUN3 Gene

Disorders for SUN3 Gene

Relevant External Links for SUN3

Genetic Association Database (GAD)
SUN3
Human Genome Epidemiology (HuGE) Navigator
SUN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUN3

No disorders were found for SUN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUN3 Gene

Publications for SUN3 Gene

  1. A disulfide bond is required for the transmission of forces through SUN-KASH complexes. (PMID: 26244732) Jahed Z. … Mofrad M.R. (Biophys. J. 2015) 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  3. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. (PMID: 19193627) ChiA^ A. … Traynor B.J. (Hum. Mol. Genet. 2009) 3 64
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for SUN3 Gene

Sources for SUN3 Gene

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