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Aliases for SUN3 Gene

Aliases for SUN3 Gene

  • Sad1 And UNC84 Domain Containing 3 2 3 5
  • Sad1/Unc-84 Domain-Containing Protein 1 3 4
  • Sad1 And UNC84 Domain Containing 1 2 3
  • SUNC1 3 4
  • SUN Domain-Containing Protein 3 3
  • Hypothetical Protein MGC33329 3

External Ids for SUN3 Gene

Previous HGNC Symbols for SUN3 Gene

  • SUNC1

Previous GeneCards Identifiers for SUN3 Gene

  • GC07M048026
  • GC07M047912

Summaries for SUN3 Gene

GeneCards Summary for SUN3 Gene

SUN3 (Sad1 And UNC84 Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is SUN2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUN3 Gene

Genomics for SUN3 Gene

Regulatory Elements for SUN3 Gene

Enhancers for SUN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F048081 1.8 FANTOM5 Ensembl ENCODE 10.4 -61.9 -61925 18.7 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF207 FOS SP3 SP5 JUNB UPP1 HUS1 ENSG00000225507 PKD1L1 SUN3 ABCA13 LOC105375271
GH07F048052 1 Ensembl ENCODE 11 -24.1 -24128 1.8 JUN ZFHX2 ZBTB48 FOS CREM EGR2 MTA2 BHLHE40 GFI1B CEBPB UPP1 SUN3 ABCA13 HUS1 C7orf57
GH07F048073 0.9 Ensembl ENCODE 11.2 -45.5 -45481 1.4 JUN MAX USF2 ZIC2 EP300 RFX5 JUND GATA3 ATF3 ZNF366 SUN3 UPP1 C7orf57
GH07F048004 0.2 Ensembl 12 +24.4 24427 0.2 SUN3 HUS1 PKD1L1 LOC105375270
GH07F047991 1.5 FANTOM5 Ensembl ENCODE 0.3 +36.9 36862 2.2 ELF3 MLX ARID4B ZNF48 RAD21 YY1 EGR1 ZNF143 EGR2 ZNF654 UPP1 PKD1L1 HUS1 ABCA13 LOC105375270 SUN3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SUN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUN3 Gene

47,987,148 bp from pter
48,029,127 bp from pter
41,980 bases
Minus strand

Genomic View for SUN3 Gene

Genes around SUN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUN3 Gene

Proteins for SUN3 Gene

  • Protein details for SUN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SUN domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A4D2F3
    • B4DXK1
    • D3DVM3
    • E7EWC8
    • Q4F965
    • Q7Z4U8

    Protein attributes for SUN3 Gene

    357 amino acids
    Molecular mass:
    40503 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAP97300.1; Type=Frameshift; Positions=233, 242; Evidence={ECO:0000305}; Sequence=EAL23808.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SUN3 Gene


neXtProt entry for SUN3 Gene

Post-translational modifications for SUN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SUN3 Gene

Domains & Families for SUN3 Gene

Protein Domains for SUN3 Gene


Suggested Antigen Peptide Sequences for SUN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SUN domain.
  • Contains 1 SUN domain.
genes like me logo Genes that share domains with SUN3: view

No data available for Gene Families for SUN3 Gene

Function for SUN3 Gene

genes like me logo Genes that share phenotypes with SUN3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SUN3 Gene

Localization for SUN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUN3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUN3 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SUN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0034993 LINC complex IEA --
genes like me logo Genes that share ontologies with SUN3: view

Pathways & Interactions for SUN3 Gene

No Data Available

Interacting Proteins for SUN3 Gene

Gene Ontology (GO) - Biological Process for SUN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IBA --
GO:0090286 cytoskeletal anchoring at nuclear membrane IBA --
genes like me logo Genes that share ontologies with SUN3: view

No data available for Pathways by source and SIGNOR curated interactions for SUN3 Gene

Transcripts for SUN3 Gene

Unigene Clusters for SUN3 Gene

Sad1 and UNC84 domain containing 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUN3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -

Relevant External Links for SUN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SUN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SUN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUN3 Gene

This gene is overexpressed in Testis (x48.1).

Protein differential expression in normal tissues from HIPED for SUN3 Gene

This gene is overexpressed in Synovial fluid (36.8) and Colon muscle (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SUN3 Gene:


SOURCE GeneReport for Unigene cluster for SUN3 Gene:

genes like me logo Genes that share expression patterns with SUN3: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SUN3 Gene

Orthologs for SUN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SUN3 34 35
  • 99.25 (n)
(Mus musculus)
Mammalia Sun3 34 16 35
  • 83.27 (n)
(Bos Taurus)
Mammalia SUN3 34 35
  • 82.95 (n)
(Rattus norvegicus)
Mammalia Sun3 34
  • 82.05 (n)
(Canis familiaris)
Mammalia SUN3 34 35
  • 80.09 (n)
(Monodelphis domestica)
Mammalia SUN3 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia SUN3 35
  • 57 (a)
(Gallus gallus)
Aves -- 35
  • 40 (a)
-- 35
  • 40 (a)
-- 35
  • 39 (a)
-- 35
  • 35 (a)
-- 35
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta koi 35
  • 16 (a)
(Caenorhabditis elegans)
Secernentea unc-84 35
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
Species where no ortholog for SUN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SUN3 Gene

Gene Tree for SUN3 (if available)
Gene Tree for SUN3 (if available)

Paralogs for SUN3 Gene

Variants for SUN3 Gene

Sequence variations from dbSNP and Humsavar for SUN3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10225968 -- 48,024,141(+) AAAAG(A/G)TTTGG intron-variant
rs10236530 -- 48,001,531(+) ttttt(G/T)ttttt intron-variant
rs10240997 -- 48,032,838(+) GAAAA(A/G)CACAA intron-variant
rs10245073 -- 48,033,914(+) CCAGG(C/T)GTGGT intron-variant, upstream-variant-2KB
rs10253220 -- 48,035,880(+) GATAC(C/T)CGGCG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SUN3 Gene

Variant ID Type Subtype PubMed ID
esv2665988 CNV deletion 23128226
esv3613065 CNV gain 21293372
esv3613073 CNV gain 21293372
esv3613076 CNV loss 21293372
nsv1128314 CNV deletion 24896259
nsv464442 CNV gain 19166990
nsv470221 CNV gain 18288195
nsv475822 CNV novel sequence insertion 20440878
nsv606893 CNV gain 21841781

Variation tolerance for SUN3 Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUN3 Gene

Disorders for SUN3 Gene

Relevant External Links for SUN3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SUN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUN3 Gene

Publications for SUN3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  2. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. (PMID: 19193627) ChiA^ A. … Traynor B.J. (Hum. Mol. Genet. 2009) 3 64
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for SUN3 Gene

Sources for SUN3 Gene

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