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Aliases for SUN2 Gene

Aliases for SUN2 Gene

  • Sad1 And UNC84 Domain Containing 2 2 3
  • UNC84B 3 4 6
  • Sad1/Unc-84 Protein-Like 2 3 4
  • Protein Unc-84 Homolog B 3 4
  • Rab5-Interacting Protein 3 4
  • KIAA0668 4 6
  • Rab5IP 3 4
  • SUN Domain-Containing Protein 2 3
  • Unc-84 Homolog B (C. Elegans) 2
  • Sad1 Unc-84 Domain Protein 2 3
  • Nuclear Envelope Protein 3
  • Unc-84 Homolog B 3
  • FRIGG 4

External Ids for SUN2 Gene

Previous HGNC Symbols for SUN2 Gene

  • UNC84B

Previous GeneCards Identifiers for SUN2 Gene

  • GC22M039132
  • GC22M022096
  • GC22M039213
  • GC22M039418
  • GC22M040102

Summaries for SUN2 Gene

Entrez Gene Summary for SUN2 Gene

  • SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]

GeneCards Summary for SUN2 Gene

SUN2 (Sad1 And UNC84 Domain Containing 2) is a Protein Coding gene. Diseases associated with SUN2 include chronic fatigue syndrome and emerinopathy. Among its related pathways are Cell Cycle, Mitotic and Meiosis. GO annotations related to this gene include identical protein binding and lamin binding. An important paralog of this gene is SUN5.

UniProtKB/Swiss-Prot for SUN2 Gene

  • Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.

Gene Wiki entry for SUN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUN2 Gene

Genomics for SUN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUN2 Gene

Start:
38,734,714 bp from pter
End:
38,794,143 bp from pter
Size:
59,430 bases
Orientation:
Minus strand

Genomic View for SUN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUN2 Gene

No data available for Regulatory Elements for SUN2 Gene

Proteins for SUN2 Gene

  • Protein details for SUN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UH99-SUN2_HUMAN
    Recommended name:
    SUN domain-containing protein 2
    Protein Accession:
    Q9UH99
    Secondary Accessions:
    • B0QY62
    • O75156
    • Q2NKN8
    • Q2T9F7
    • Q504T5
    • Q6B4H1
    • Q7Z3E3

    Protein attributes for SUN2 Gene

    Size:
    717 amino acids
    Molecular mass:
    80311 Da
    Quaternary structure:
    • Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN domain-containing proteins interact with A-type lamins of the nuclear lamina, while at the other end of the complex, nesprins interact with unique cytoskeletal components. Interacts with SYNE1, SYNE2 and SYNE3. Interacts with A-type lamin. Interaction with lamins B1 and C is hardly detectable (By similarity). Interacts with EMD and RAB5A. Interacts with TMEM43.
    SequenceCaution:
    • Sequence=BAA31643.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUN2 Gene

    Alternative splice isoforms for SUN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUN2 Gene

Proteomics data for SUN2 Gene at MOPED

Post-translational modifications for SUN2 Gene

  • Ubiquitination at Lys300, Lys392, Lys409, Lys491, Lys533, and Lys570
  • Glycosylation at Asn636
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SUN2 Gene

Domains for SUN2 Gene

Protein Domains for SUN2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SUN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UH99

UniProtKB/Swiss-Prot:

SUN2_HUMAN :
  • Q9UH99
Domain:
  • The SUN domain may play a role in the nuclear anchoring and/or migration
  • Contains 1 SUN domain.
genes like me logo Genes that share domains with SUN2: view

No data available for Gene Families for SUN2 Gene

Function for SUN2 Gene

Molecular function for SUN2 Gene

UniProtKB/Swiss-Prot Function: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.

Gene Ontology (GO) - Molecular Function for SUN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18396275
GO:0005521 lamin binding IDA 19933576
GO:0008017 microtubule binding TAS 10375507
GO:0042802 identical protein binding IPI 22632968
genes like me logo Genes that share ontologies with SUN2: view
genes like me logo Genes that share phenotypes with SUN2: view

Animal Models for SUN2 Gene

MGI Knock Outs for SUN2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SUN2 Gene

Localization for SUN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUN2 Gene

Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUN2 Gene COMPARTMENTS Subcellular localization image for SUN2 gene
Compartment Confidence
endosome 5
nucleus 5
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SUN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IEA --
GO:0000794 condensed nuclear chromosome IEA --
GO:0005635 nuclear envelope TAS 10375507
GO:0005637 nuclear inner membrane --
GO:0005639 integral component of nuclear inner membrane IEA --
genes like me logo Genes that share ontologies with SUN2: view

Pathways for SUN2 Gene

genes like me logo Genes that share pathways with SUN2: view

Pathways by source for SUN2 Gene

4 Reactome pathways for SUN2 Gene

Gene Ontology (GO) - Biological Process for SUN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IGI 16380439
GO:0007052 mitotic spindle organization TAS 10375507
GO:0007097 nuclear migration TAS 10508607
GO:0030335 positive regulation of cell migration ISS --
GO:0031022 nuclear migration along microfilament ISS --
genes like me logo Genes that share ontologies with SUN2: view

Transcripts for SUN2 Gene

Unigene Clusters for SUN2 Gene

Sad1 and UNC84 domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUN2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SUN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a · 10b ^ 11 ^
SP1: - - - - - - -
SP2: - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6:
SP7:
SP8: - - - - - - - - -
SP9: - - - -
SP10:
SP11:
SP12: - - - - - - - - - - -
SP13: - - - - - -
SP14: - - - - - - - -
SP15: - -
SP16: -
SP17: - -
SP18:
SP19:

ExUns: 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6: - - - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - -

Relevant External Links for SUN2 Gene

GeneLoc Exon Structure for
SUN2
ECgene alternative splicing isoforms for
SUN2

Expression for SUN2 Gene

mRNA expression in normal human tissues for SUN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SUN2 Gene

SOURCE GeneReport for Unigene cluster for SUN2 Gene Hs.517622

mRNA Expression by UniProt/SwissProt for SUN2 Gene

Q9UH99-SUN2_HUMAN
Tissue specificity: Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects.
genes like me logo Genes that share expressions with SUN2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SUN2 Gene

Orthologs for SUN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUN2 35
  • 99.3 (n)
  • 99.3 (a)
SUN2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUN2 35
  • 84.64 (n)
  • 84.36 (a)
UNC84B 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUN2 35
  • 85.29 (n)
  • 86.31 (a)
SUN2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sun2 35
  • 82.33 (n)
  • 82.15 (a)
Sun2 16
Sun2 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUN2 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUN2 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sun2 35
  • 82.94 (n)
  • 83.26 (a)
chicken
(Gallus gallus)
Aves SUN2 35
  • 61.14 (n)
  • 51.85 (a)
SUN2 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUN2 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sun2 35
  • 52.37 (n)
  • 45.76 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-92f12.2 35
  • 49.48 (n)
  • 44.74 (a)
SUN2 36
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta koi 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-84 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for SUN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUN2 Gene

ENSEMBL:
Gene Tree for SUN2 (if available)
TreeFam:
Gene Tree for SUN2 (if available)

Paralogs for SUN2 Gene

Paralogs for SUN2 Gene

Pseudogenes.org Pseudogenes for SUN2 Gene

genes like me logo Genes that share paralogs with SUN2: view

Variants for SUN2 Gene

Sequence variations from dbSNP and Humsavar for SUN2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs9835 -- 38,734,966(+) CAGCC(A/G)GACCA utr-variant-3-prime
rs14670 -- 38,736,284(-) TGCAT(G/T)GGGAG reference, missense
rs17032 -- 38,734,838(+) ACAAA(C/G)CCTGG utr-variant-3-prime
rs138702 -- 38,736,596(+) ACTTC(A/T)TCTGA intron-variant
rs138703 -- 38,736,743(+) CCACA(A/G)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUN2 Gene

Variant ID Type Subtype PubMed ID
nsv915067 CNV Loss 21882294
nsv915068 CNV Loss 21882294
dgv769n67 CNV Gain 20364138
esv991516 CNV Deletion 20482838

Relevant External Links for SUN2 Gene

HapMap Linkage Disequilibrium report
SUN2
Human Gene Mutation Database (HGMD)
SUN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUN2 Gene

Disorders for SUN2 Gene

(9) Novoseek inferred disease relationships for SUN2 Gene

Disease -log(P) Hits PubMed IDs
muscular dystrophy emery-dreifuss 91.7 3
limb girdle 63.7 1
dilated cardiomyopathy 60.4 2
biliary cirrhosis primary 53.8 5
muscular dystrophies 53.4 2

Relevant External Links for SUN2

Human Genome Epidemiology (HuGE) Navigator
SUN2
genes like me logo Genes that share disorders with SUN2: view

No data available for UniProtKB/Swiss-Prot for SUN2 Gene

Publications for SUN2 Gene

  1. Isolation of differentially expressed genes in human heart tissues. (PMID: 12393179) Sun G. … Ping Leung M. (Biochim. Biophys. Acta 2002) 3 4 23
  2. UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development. (PMID: 10375507) Malone C.J. … Han M. (Development 1999) 2 3 4
  3. The missing (L) UNC? (PMID: 10508607) Raff J.W. (Curr. Biol. 1999) 2 3
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  5. A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion. (PMID: 10818110) Hoffenberg S. … Knoll B.J. (J. Biol. Chem. 2000) 3 4

Products for SUN2 Gene

Sources for SUN2 Gene

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