SUN2 Gene
protein-coding GIFtS: 57
GCID: GC22M039213
|
|
Sad1 and UNC84 domain containing 2(Previous name: unc-84 homolog B (C. elegans) )
(Previous symbol: UNC84B)
| |
Aliases
for SUN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sad1 And UNC84 Domain Containing 21 2 | | Sad1 Unc-84 Domain Protein 22 | | UNC84B1 2 3 | | SUN Domain-Containing Protein 22 | | Protein Unc-84 Homolog B2 3 | | Unc-84 Homolog B2 | | Rab5-Interacting Protein2 3 | | FRIGG3 | | Sad1/Unc-84 Protein-Like 22 3 | | KIAA06683 | | Unc-84 Homolog B (C. Elegans)1 | | RAB5IP3 | | Nuclear Envelope Protein2 | | Rab5IP3 | | Rab5IP3 | | |
Export aliases for SUN2 gene to outside databasesPrevious GC identifers: GC22M039132 GC22M022096 |
Summaries
for SUN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SUN2:
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmicconnection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with theconserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). TheLINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes tonuclear positioning and cellular rigidity (summary by Haque et al., 2010 (PubMed 19933576)).(supplied by OMIM, Nov2010)
UniProtKB/Swiss-Prot: SUN2_HUMAN, Q9UH99Function: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link thenucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletalfilaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines whichare bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement.Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus couplingduring radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in theprophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed forgametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocyticvesicles as a receptor for RAB5-GDP and participate in the activation of RAB5
Gene Wiki entry for SUN2 (UNC84B)
|
Genomic Views
for SUN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SUN2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SUN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q12-q13SUN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M039213: view genomic region
(about GC identifiers)
Start:
|
39,130,730 bp from pter |
End:
|
39,190,148 bp from pter |
Size:
|
59,419 bases |
Orientation:
|
minus strand |
|
Proteins
for SUN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SUN2_HUMAN, Q9UH99 (See
protein sequence)Recommended Name: SUN domain-containing protein 2 Size: 717 amino acids; 80311 Da
Subunit: Component of LINC complexes composed of SUN domain-containing proteins SUN1 or SUN2 coupled to KASHdomain-containing proteins (SYNE1, SYNE2 or SYNE3), also called nesprins. Interacts with EMD, LMNA, RAB5A, SYNE1,SYNE2 and SYNE3
Subcellular location: Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass typeII membrane protein (Probable)
Caution: It is uncertain whether Met-1 or Met-50 is the initiator
Sequence caution: Sequence=BAA31643.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
5 PDB 3D structures from  and Proteopedia  for SUN2:3UNP (3D)
4DXR (3D)
4DXS (3D)
4DXT (3D)
4FI9 (3D)
Secondary accessions: B0QY62 O75156 Q2NKN8 Q504T5 Q6B4H1 Q7Z3E3Alternative splicing: 2 isoforms: Q9UH99-1 Q9UH99-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SUN2: NX_Q9UH99
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UH99
SUN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001186508.1 NP_001186509.1 NP_056189.1
ENSEMBL proteins: ENSP00000385740 ENSP00000385616 ENSP00000383992 ENSP00000390154 ENSP00000403694 ENSP00000406941 ENSP00000415588 ENSP00000408834 ENSP00000414950 ENSP00000411615 ENSP00000412928 ENSP00000393271 ENSP00000395601 ENSP00000216064 Reactome Protein details: Q9UH99
Human Recombinant Protein Products for SUN2:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
SUN2 for ontologies About GeneDecksing
SUN2 Antibody Products:
Assay Products for SUN2: |
Protein
Domains /
Families
for SUN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SUN2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UH99ProtoNet protein and cluster: Q9UH99 1 Blocks protein family: IPB012919 Sad1/UNC-like
UniProtKB/Swiss-Prot: SUN2_HUMAN, Q9UH99Domain: The SUN domain may play a role in the nuclear anchoring and/or migrationSimilarity: Contains 1 SUN domain |
Function
for SUN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SUN2_HUMAN, Q9UH99Function: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link thenucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletalfilaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines whichare bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement.Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus couplingduring radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in theprophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed forgametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocyticvesicles as a receptor for RAB5-GDP and participate in the activation of RAB5 Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SUN2 for ontologies About GeneDecksing
Phenotypes:
3 GenomeRNAi human phenotypes for SUN2:
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Sun2):
SUN2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Sun2tm1Mhan for SUN2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUN2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUN2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): SUN2 (NM_015374) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SUN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUN2 |
|
Pathways & Interactions
for SUN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Meiotic Synapsis | | | 2 | Cell Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for SUN2
SUN2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SUN2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/46 Interacting proteins for SUN2 (Q9UH991, 2, 3 ENSP000002160644) via UniProtKB, MINT, STRING, and/or I2D (see all 46)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
SUN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SUN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SUN2
Search CenterWatch for drugs/clinical trials and news about SUN2
|
Transcripts
for SUN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SUN2 gene (3 alternative transcripts): NM_001199579.1 NM_001199580.1 NM_015374.2 Unigene Cluster for SUN2: Sad1 and UNC84 domain containing 2 Hs.517622 [show with all ESTs]Unigene Representative Sequence: NM_00119957918/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000405510(uc011anz.2 uc011aoa.2 uc003awh.2 uc010gxr.2)
ENST00000405018(uc010gxq.2 uc003awi.2) ENST00000406622 ENST00000455125
ENST00000470642 ENST00000477262 ENST00000469086 ENST00000464202 ENST00000430185
ENST00000438058 ENST00000456894 ENST00000480307 ENST00000420859 ENST00000452294
ENST00000494273 ENST00000433561 ENST00000417332 ENST00000439339
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUN2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUN2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SUN2 (NM_015374) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SUN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUN2 |
Additional cDNA sequence: AB014568.1 AF038178.1 AF202723.1 AK295787.1 AK304188.1 AY682988.1 BC030684.2 BC069253.1 BC094797.1 BC111549.1 BC111717.1 BX537962.1 CR456474.1 24/27 DOTS entries (see all 27): DT.100888534 DT.317752 DT.100712670 DT.95234493 DT.99980201 DT.100888531 DT.91985673 DT.100888536 DT.100888528 DT.120664951 DT.91926609 DT.92439577 DT.99932419 DT.100705092 DT.100888526 DT.100888539 DT.100888543 DT.40270436 DT.92439579 DT.95203185 DT.102832225 DT.120664782 DT.120664854 DT.120664816 24/393 AceView cDNA sequences (see all 393): BX345098 BM564362 CA407481 BM701823 AI247287 AW002052 BM709723 AF202723 BG222850 BM905022 M79048 BF724952 BU631730 AI016027 BE939856 BF725174 AW264005 CB268287 BU429934 BF360628 AI125877 CR456474 BX451208 F29929
GeneLoc Exon Structure
5/19 Alternative Splicing Database (ASD) splice patterns (SP) for SUN2 (see all 19) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | | | | | | | | |
| ExUns: | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SUN2
|
Expression
for SUN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SUN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGCTGGATG
About this image
See SUN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SUN2
SOURCE GeneReport for Unigene cluster: Hs.517622
UniProtKB/Swiss-Prot: SUN2_HUMAN, Q9UH99Tissue specificity: Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart.Slightly overexpressed in some heart tissues form patients with congenital heart defects
SABiosciences Custom PCR Arrays for SUN2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SUN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUN2 |
Orthologs
for SUN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SUN2 gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC4180211 |
SUN domain-containing protein 2-like |
63.25(n)
54.9(a) |
|
418021 XM_416257.3 XP_416257.3 |
lizard
(Anolis carolinensis) |
Reptilia |
SUN26 |
-- |
55(a) |
1 ↔ 1 |
5(24202539-24234364) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7967611 |
SUN domain-containing protein 2-like |
48.13(n)
42.46(a) |
|
796761 XM_001919656.3 XP_001919691.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
koi6spag46 |
sperm-associated antigen 4 |
23(a)15(a) |
1 ↔ manypossible ortholog |
2R(2702565-2705704) 2L(11610510-11611772) |
worm
(Caenorhabditis elegans) |
Secernentea |
unc-846 |
Nuclear migration and anchoring protein unc-84 |
9(a) |
1 → many |
X(13584705-13589757) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SUN26ATSUN16 |
SAD1/UNC-84 domain protein 1 |
19(a)17(a) |
many ↔ manymany ↔ many |
3(3358328-3360682) 5(1471481-1473964) |
rice
(Oryza sativa) |
Liliopsida |
---- |
Sad1 / UNC-like C-terminal domain containing prote...Sad1 / UNC-like C-terminal domain containing prote... |
21(a)18(a) |
many ↔ manymany ↔ many |
5(10883292-10886698) 1(9178212-9180984) |
ENSEMBL Gene Tree for SUN2 (if available)
TreeFam Gene Tree for SUN2 (if available) |
Paralogs
for SUN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SUN2 gene
- SPAG42 SUN12 SUN32 SUN52
6 SIMAP similar genes for SUN2 using alignment to 11 protein entries: SUN2_HUMAN (see all proteins):UNC84B SUN3 UNC84A SUN1 SPAG4 SUN5
SUN2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SUN2
PGOHUM00000259707
|
Genomic Variants
for SUN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SUN2 (39130730 - 39190148 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SUN2: --
Human Gene Mutation Database (HGMD): SUN2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SUN2 |
|
Disorders
/ Diseases
for SUN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SUN2 for disorders About GeneDecksing
OMIM gene information: 613569
OMIM disorders: --
20/21  diseases for SUN2 (see all 21): About MalaCardsemery-dreifuss muscular dystrophy muscular dystrophy chronic fatigue syndrome dilated cardiomyopathy
non-hodgkin lymphoma emerinopathy familial dilated cardiomyopathy primary biliary cirrhosis
congenital heart defect neuromuscular disease reynolds syndrome systemic lupus erythematosus
lupus erythematosus hodgkin's lymphoma cardiomyopathy liver disease
fibromyalgia genetic disease colorectal cancer cerebritis
9 Novoseek disease relationships for SUN2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: SUN2 (1 document)
Export disorders for SUN2 gene to outside databases
|
Publications
for SUN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SUN2 gene, integrated from 9 sources (see all 130):
(articles sorted by number of sources associating them with SUN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development. (PubMed id 10375507)1, 2, 3 Malone C.J.... Han M. (1999)
- Isolation of differentially expressed genes in human heart tissues. (PubMed id 12393179)1, 2, 9 Sun G....Ping Leung M. (2002)
- Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. (PubMed id 18396275)1, 2 Stewart-Hutchinson P.J.... Hodzic D. (2008)
- Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome. (PubMed id 17132086)1, 2 Wang Q....Greene M.I. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PubMed id 12958361)1, 2 Schirmer E.C....Gerace L. (2003)
- A mass spectrometry-based proteomic approach for identification of serine/threonine-phosphorylated proteins by enrichment with phospho- specific antibodies: identification of a novel protein, Frigg, as a protein kinase A substrate. (PubMed id 12239280)1, 2 Gronborg M.... Pandey A. (2002)
- A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion. (PubMed id 10818110)1, 2 Hoffenberg S.... Knoll B.J. (2000)
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External Searches for SUN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing SUN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SUN2 gene
(According to HUGE)
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Specialized Databases showing SUN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for SUN2 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for SUN2 gene:
Search GeneIP for patents involving SUN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SUN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for SUN2 | | OriGene shRNA RFP for SUN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUN2 | | | OriGene Protein Over-expression Lysate for SUN2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SUN2 | | OriGene 3'-UTR Clone for SUN2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SUN2 | | OriGene Custom Protein Services for SUN2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SUN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SUN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUN2 |
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| | | | Search Tocris compounds for SUN2 |
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 | | | SUN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUN2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SUN2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUN2 |
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