Aliases for SUN1 Gene
External Ids for SUN1 Gene
Previous HGNC Symbols for SUN1 Gene
Previous GeneCards Identifiers for SUN1 Gene
This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2010]
GeneCards Summary for SUN1 Gene
SUN1 (Sad1 And UNC84 Domain Containing 1) is a Protein Coding gene. Diseases associated with SUN1 include hypertrophy of breast and emery-dreifuss muscular dystrophy. Among its related pathways are Cell Cycle, Mitotic and Meiosis. GO annotations related to this gene include lamin binding. An important paralog of this gene is SUN5.
UniProtKB/Swiss-Prot for SUN1 Gene
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity).