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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUN1 Gene

protein-coding   GIFtS: 59
GCID: GC07P000857

Sad1 And UNC84 Domain Containing 1

(Previous name: unc-84 homolog A (C. elegans))
(Previous symbol: UNC84A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sad1 And UNC84 Domain Containing 11 2     KIAA08103 5
UNC84A1 2 3 5     Unc-84 Homolog A (C. Elegans)1
Sad1 Unc-84 Domain Protein 11 2     SUN Domain-Containing Protein 12
Protein Unc-84 Homolog A2 3     Unc-84 Homolog A2
Sad1/Unc-84 Protein-Like 12 3     

External Ids:    HGNC: 185871   Entrez Gene: 233532   Ensembl: ENSG000001648287   OMIM: 6077235   UniProtKB: O949013   

Export aliases for SUN1 gene to outside databases

Previous GC identifers: GC07P000856 GC07P000773


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUN1 Gene:
This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84
(SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript
variants have been described. (provided by RefSeq, Jan 2010)

GeneCards Summary for SUN1 Gene: 
SUN1 (Sad1 and UNC84 domain containing 1) is a protein-coding gene. Diseases associated with SUN1 include emery-dreifuss muscular dystrophy, and progeria, and among its related super-pathways are Meiotic Synapsis and Cell Cycle, Mitotic. GO annotations related to this gene include protein binding. An important paralog of this gene is SPAG4.

UniProtKB/Swiss-Prot: SUN1_HUMAN, O94901
Function: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the
nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal
filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and
centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration.
Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and
non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis.
Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity)

Gene Wiki entry for SUN1 (UNC84A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SUN1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): SUN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SUN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

SUN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUN1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P000857:  view genomic region     (about GC identifiers)

Start:
855,194 bp from pter      End:
936,072 bp from pter
Size:
80,879 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 909,796-969,506     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SUN1_HUMAN, O94901 (See protein sequence)
Recommended Name: SUN domain-containing protein 1  
Size: 812 amino acids; 90064 Da
Subunit: Dimers and tetramers (By similarity). Component of LINC complexes composed of SUN domain-containing
proteins SUN1 or SUN2 coupled to KASH domain-containing proteins (SYNE1, SYNE2 or SYNE3), also called nesprins.
Interacts with TSNAX (By similarity). Interacts with EMD, LMNA, NAT10, SYNE1, SYNE2 and SYNE3. Associates with
the nuclear pore complex (NPC) (By similarity). Interacts with CCDC155 (via the last 22 AA); this interaction
mediates CCDC155 telomere localization (By similarity)
Subcellular location: Nucleus inner membrane; Single-pass type II membrane protein
Sequence caution: Sequence=BAA34530.1; Type=Erroneous initiation;
Secondary accessions: A5PL20 B3KMV7 B4DZF7 B7WNY4 B7WP53 E9PDU4 E9PF23 F8WD13 Q96CZ7 Q9HA14
Q9UH98
Alternative splicing: 9 isoforms:  O94901-1   O94901-2   O94901-3   O94901-4   O94901-5   O94901-6   O94901-7   O94901-8   
O94901-9   (No experimental confirmation available. Contains a phosphoserine at position 333)

Explore the universe of human proteins at neXtProt for SUN1: NX_O94901

Explore proteomics data for SUN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94901

  • SUN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SUN1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001124437.1  NP_001165415.1  NP_001165416.1  NP_001165417.1  NP_079430.3  

    ENSEMBL proteins: 
     ENSP00000374225   ENSP00000388430   ENSP00000399549   ENSP00000413188   ENSP00000394597  
     ENSP00000404965   ENSP00000394381   ENSP00000384116   ENSP00000384015   ENSP00000383947  
     ENSP00000392595   ENSP00000414279   ENSP00000409909   ENSP00000406653   ENSP00000406444  
     ENSP00000388743   ENSP00000395952   ENSP00000413439   ENSP00000392309   ENSP00000389313  
    Reactome Protein details: O94901
    Human Recombinant Protein Products for SUN1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for SUN1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SUN1
    GenScript Custom Purified and Recombinant Proteins Services for SUN1
    Novus Biologicals SUN1 Proteins
    Novus Biologicals SUN1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUN1 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002080acrosomal membrane IEA--
    GO:0005634nucleus ----
    GO:0005635nuclear envelope IDA19933576
    GO:0005637nuclear inner membrane ----
    GO:0005639integral to nuclear inner membrane IEA--

    SUN1 for ontologies           About GeneDecksing



    SUN1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Antibodies for SUN1
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    Novus Biologicals SUN1 Antibodies
    Abcam antibodies for SUN1
    Cloud-Clone Corp. Antibodies for SUN1 
    ThermoFisher Antibodies for SUN1
    LSBio Antibodies in human, mouse, rat for SUN1 

    Assay Products for SUN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SUN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SUN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SUN1 
    Cloud-Clone Corp. CLIAs for SUN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR012919 Sad1_UNC_C
     IPR018539 RNA-bd_mt

    Graphical View of Domain Structure for InterPro Entry O94901

    ProtoNet protein and cluster: O94901

    1 Blocks protein domain: IPB012919 Sad1/UNC-like

    UniProtKB/Swiss-Prot: SUN1_HUMAN, O94901
    Domain: The SUN domain may play a role in the nuclear anchoring and/or migration
    Similarity: Contains 1 SUN domain


    SUN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUN1_HUMAN, O94901
    Function: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the
    nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal
    filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and
    centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration.
    Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and
    non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis.
    Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18396275
    GO:0005521lamin binding IEA--
         
    SUN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SUN1:
     Increased gamma-H2AX phosphory 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sun1):
     behavior/neurological  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  homeostasis/metabolism 
     mortality/aging  muscle  nervous system  no phenotypic analysis  reproductive system 

    SUN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SUN1: Sun1tm1Mhan Sun1tm1.1Ktj

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SUN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUN1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUN1
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate SUN1 (see all 39):
    hsa-miR-142-5p hsa-miR-300 hsa-miR-4272 hsa-miR-25 hsa-miR-29a hsa-miR-1304 hsa-miR-92b hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidSUN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SUN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SUN1
    Sirion Biotech Customized adenovirus for overexpression of SUN1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SUN1 (see all 22)
    OriGene ORF clones in mouse, rat for SUN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): SUN1 (NM_001130965)
    Sino Biological Human cDNA Clone for SUN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUN1
    Sirion Biotech Customized lentivirus for stable overexpression of SUN1 
                         Customized lentivirus expression plasmids for stable overexpression of SUN1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SUN1
    Search LifeMap BioReagents cell lines for SUN1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SUN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Meiotic Synapsis
    Meiotic Synapsis0.70
    Chromosome Maintenance0.56
    Meiosis0.70
    2Cell Cycle
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for SUN1
        Meiotic Synapsis
    Cell Cycle
    Meiosis
    Chromosome Maintenance



    SUN1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SUN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for SUN1 (O949011, 3 ENSP000003840154) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSNAXQ995983, ENSP000003555994I2D: score=5 STRING: ENSP00000355599
    TOLLIPQ9H0E23I2D: score=2 
    LMNAP025453I2D: score=1 
    SYNE1Q8NF91-11, ENSP000002653684EBI-2796904,EBI-6170938 STRING: ENSP00000265368
    LMNB1ENSP000002613664STRING: ENSP00000261366
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006998nuclear envelope organization IGI16380439
    GO:0090286cytoskeletal anchoring at nuclear membrane IDA18396275
    GO:0090292nuclear matrix anchoring at nuclear membrane IDA18396275

    SUN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUN1

    Search CenterWatch for drugs/clinical trials and news about SUN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUN1 gene (5 alternative transcripts): 
    NM_001130965.2  NM_001171944.1  NM_001171945.1  NM_001171946.1  NM_025154.5  

    Unigene Cluster for SUN1:

    Sad1 and UNC84 domain containing 1
    Hs.438072  [show with all ESTs]
    Unigene Representative Sequence: BC142707
    18/37 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 37):
    ENST00000427969 ENST00000450538 ENST00000389574 ENST00000435699 ENST00000440380
    ENST00000439679 ENST00000424128 ENST00000457598 ENST00000421580 ENST00000340926(uc003sje.1)
    ENST00000405266 ENST00000413171 ENST00000401592 ENST00000403868 ENST00000467483
    ENST00000483996 ENST00000469755 ENST00000450881
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUN1
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate SUN1 (see all 39):
    hsa-miR-142-5p hsa-miR-300 hsa-miR-4272 hsa-miR-25 hsa-miR-29a hsa-miR-1304 hsa-miR-92b hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidSUN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SUN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUN1
    Clone
    Products:
         
    OriGene clones in human, mouse for SUN1 (see all 22)
    OriGene ORF clones in mouse, rat for SUN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): SUN1 (NM_001130965)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUN1
    Sirion Biotech Customized lentivirus for stable overexpression of SUN1 
                         Customized lentivirus expression plasmids for stable overexpression of SUN1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SUN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SUN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUN1

    Additional mRNA sequence: 

    AF202724.1 AK022816.1 AK025737.1 AK074320.1 AK302896.1 AK304150.1 AK309120.1 AY776160.1 
    BC013613.1 BC113916.1 BC142707.1 BX649069.1 

    24/39 DOTS entries (see all 39):

    DT.87016779  DT.101957440  DT.100794357  DT.121644616  DT.100840732  DT.100666045  DT.40229280  DT.121052456 
    DT.100671866  DT.100794360  DT.408830  DT.121052442  DT.97816093  DT.121052437  DT.209433  DT.91935779 
    DT.100794355  DT.100794359  DT.121052514  DT.455873  DT.100794352  DT.100794354  DT.121052406  DT.121052512 

    24/367 AceView cDNA sequences (see all 367):

    BM988617 CR591842 CD723301 BU616362 AL044709 AI199099 AI582998 AI369907 
    BM788609 BM689998 BQ890097 AI627321 BM782607 CB306727 BU685099 AL047408 
    AI160503 BM830991 AI265945 AI564855 CB270047 AA749086 BX648893 CA425769 

    GeneLoc Exon Structure

    5/29 Alternative Splicing Database (ASD) splice patterns (SP) for SUN1 (see all 29)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a ·
    SP1:                                                                                                                    -           -     -     -     -     -   
    SP2:                                      -                       -     -     -                             -     -     -     -     -     -     -     -     -   
    SP3:                                                                                                                                -     -           -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d · 16e · 16f ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a ·
    SP1:                    -     -                       -                                   -                                         -           -               
    SP2:  -                 -     -                       -                                   -                                         -           -               
    SP3:                    -     -                       -                                   -                                         -           -               
    SP4:                                                                                      -                                         -           -               
    SP5:                                                  -                                   -                                                                     


    ECgene alternative splicing isoforms for SUN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUN1 expression in normal human tissues (normalized intensities)      SUN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGAATATG
    SUN1 Expression
    About this image


    SUN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 3 entries
             salivary gland ; glandular cells   
             buccal mucosa   

    See SUN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUN1

    SOURCE GeneReport for Unigene cluster: Hs.438072
        SABiosciences Expression via Pathway-Focused PCR Array including SUN1: 
              Telomeres & Telomerase in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SUN1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sun11 , 5 Sad1 and UNC84 domain containing 11, 5 74.29(n)1
    70.65(a)1
      5 (78.12 cM)5
    770531  NM_001256115.11  NP_001243044.11 
     1392006375 
    chicken
    (Gallus gallus)
    Aves SUN11 Sad1 and UNC84 domain containing 1 64.15(n)
    56.28(a)
      416449  XM_414757.3  XP_414757.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    70(a)
    46(a)
    1 ↔ many
    1 ↔ many
    AAWZ02040058(3418-7433)
    GL343385.1(661097-679295)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.244662 Xenopus laevis transcribed sequences 79.31(n)    BJ100155.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sun11 Sad1 and UNC84 domain containing 1 54.6(n)
    46.15(a)
      553188  NM_001018135.1  NP_001018145.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta koi6
    spag46
    sperm-associated antigen 4
    26(a)
    22(a)
    1 ↔ many
    possible ortholog
    2R(2702565-2705704)
    2L(11610510-11611772)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-846
    Nuclear migration and anchoring protein unc-84
    13(a)
    possible ortholog
    X(13584775-13589827)


    ENSEMBL Gene Tree for SUN1 (if available)
    TreeFam Gene Tree for SUN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUN1 gene
    SPAG42  SUN22  SUN32  SUN52  
    6 SIMAP similar genes for SUN1 using alignment to 13 protein entries:     SUN1_HUMAN (see all proteins):
    UNC84A    SUN3    SPAG4    SUN2    UNC84B    SUN5

    SUN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1776 SNPs in SUN1 are shown (see all 1776)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506444611,2
    C--853229(+) GCGTCC/TGGTCT 1 -- us2k10--------
    rs1868970231,2
    --853613(+) CTCTAC/GTGACA 1 -- us2k10--------
    rs1133428521,2
    C--853643(+) GGCACG/AGCCAT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1851113471,2
    --853651(+) CATCTA/GCCAAA 1 -- us2k10--------
    rs1397472641,2
    C--853655(+) TGCCAA/CAATCT 1 -- us2k10--------
    rs1498322271,2
    --853838(+) ACCAGC/TCTGGG 1 -- us2k10--------
    rs69611851,2
    C--853893(+) aggccG/Aaggcg 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs78082351,2
    C--853922(+) gagatC/G/Tgagac 1 -- us2k10--------
    rs1121364111,2
    C,F--853923(+) AGATCG/AAGACC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1825807651,2
    --853943(+) AACACA/GGTGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SUN1 (855194 - 936072 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for SUN1 (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2208128CNV Deletion18987734
    esv1417298CNV Deletion17803354
    esv2733670CNV Deletion23290073
    esv5081CNV Deletion18987735
    esv994061CNV Deletion20482838
    esv997325CNV Deletion20482838
    esv2733669CNV Deletion23290073
    esv2485286CNV Deletion19546169
    esv2733668CNV Deletion23290073
    esv2661195CNV Deletion23128226

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607723    OMIM disorders: --

    5 diseases for SUN1:    About MalaCards
    emery-dreifuss muscular dystrophy    progeria    muscular dystrophy    cerebritis
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for SUN1:
    Emery-Dreifuss muscular dystrophy     Progeria

    SUN1 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: SUN1 (4 documents)

    Export disorders for SUN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUN1 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with SUN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. (PubMed id 19933576)1, 2 Haque F.... Shackleton S. (2010)
    2. Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. (PubMed id 18396275)1, 2 Stewart-Hutchinson P.J.... Hodzic D. (2008)
    3. Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. (PubMed id 17631499)1, 2 Chi Y.H....Jeang K.T. (2007)
    4. Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome. (PubMed id 17132086)1, 2 Wang Q....Greene M.I. (2006)
    5. Nuclear envelope localization of human UNC84A does not require nuclear lamins. (PubMed id 16445915)1, 2 Hasan S....Kutay U. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PubMed id 12958361)1, 2 Schirmer E.C....Gerace L. (2003)
    10. Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane. (PubMed id 11593002)1, 3 Dreger M....Hucho F. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23353 HGNC: 18587 AceView: UNC84A Ensembl:ENSG00000164828 euGenes: HUgn23353
    ECgene: SUN1 H-InvDB: SUN1

    (According to HUGE)
    About This Section
    HUGE: KIAA0810

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUN1 gene:
    Search GeneIP for patents involving SUN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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