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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SUN1 Gene

protein-coding GIFtS: 56
GCID: GC07P000857

Sad1 and UNC84 domain containing 1

(Previous name: unc-84 homolog A (C. elegans) )
(Previous symbol: UNC84A)

Explore 5 diseases affiliated with
SUN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sad1 And UNC84 Domain Containing 1¹ ²		FLJ12407¹
UNC84A¹ ² ³ ⁵		Unc-84 Homolog A (C. Elegans)¹
KIAA0810¹ ³ ⁵		Sad1 Unc-84 Domain Protein 1²
Protein Unc-84 Homolog A² ³		SUN Domain-Containing Protein 1²
Sad1/Unc-84 Protein-Like 1² ³		Unc-84 Homolog A²

External Ids:	HGNC: 18587¹	Entrez Gene: 23353²	Ensembl: ENSG00000164828⁷	OMIM: 607723⁵	UniProtKB: O94901³

Export aliases for SUN1 gene to outside databases

Previous GC identifers: GC07P000856 GC07P000773

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUN1:

This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN)

domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have

been described. (provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: SUN1_HUMAN, O94901

Function: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the

nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal

filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus

coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome

movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed

for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the

distribution of nuclear pore complexes (NPCs) (By similarity)

Gene Wiki entry for SUN1 (UNC84A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SUN1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): SUN1 promoter sequence

Search SABiosciences Chromatin IP Primers for SUN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22.3

SUN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUN1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P000857: view genomic region (about GC identifiers)

Start:	855,194 bp from pter	End:	936,072 bp from pter
Size:	80,879 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 909,796-969,506

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SUN1_HUMAN, O94901 (See protein sequence)

Recommended Name: SUN domain-containing protein 1

Size: 812 amino acids; 90064 Da

Subunit: Dimers and tetramers (By similarity). Component of LINC complexes composed of SUN domain-containing proteins

SUN1 or SUN2 coupled to KASH domain-containing proteins (SYNE1, SYNE2 or SYNE3), also called nesprins. Interacts with

TSNAX (By similarity). Interacts with EMD, LMNA, NAT10, SYNE1, SYNE2 and SYNE3. Associates with the nuclear pore

complex (NPC) (By similarity). Interacts with CCDC155 (via the last 22 AA); this interaction mediates CCDC155 telomere

localization (By similarity)

Subcellular location: Nucleus inner membrane; Single-pass type II membrane protein

Sequence caution: Sequence=BAA34530.1; Type=Erroneous initiation;

Secondary accessions: A5PL20 B3KMV7 B4DZF7 B7WNY4 B7WP53 E9PDU4 E9PF23 F8WD13 Q96CZ7 Q9HA14 Q9UH98

Alternative splicing: 8 isoforms: O94901-1 O94901-2 O94901-3 O94901-4 O94901-5 O94901-6 O94901-7 O94901-8

(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SUN1: NX_O94901

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O94901

SUN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001124437.1 NP_001165415.1 NP_001165416.1 NP_001165417.1 NP_079430.3

ENSEMBL proteins:

ENSP00000374225 ENSP00000388430 ENSP00000399549 ENSP00000413188 ENSP00000394597

ENSP00000404965 ENSP00000394381 ENSP00000384116 ENSP00000384015 ENSP00000383947

ENSP00000392595 ENSP00000414279 ENSP00000409909 ENSP00000406653 ENSP00000406444

ENSP00000388743 ENSP00000395952 ENSP00000413439 ENSP00000392309 ENSP00000389313

Reactome Protein details: O94901
Human Recombinant Protein Products for SUN1:

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	Novus Biologicals SUN1 Proteins Novus Biologicals SUN1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SUN1

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002080	acrosomal membrane	--	--
GO:0005634	nucleus	--	--
GO:0005635	nuclear envelope	IDA	19933576
GO:0005637	nuclear inner membrane	IEA	--
GO:0005639	integral to nuclear inner membrane	--	--

SUN1 for ontologies About GeneDecksing

SUN1 Antibody Products:

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	Novus Biologicals SUN1 Antibodies
	Abcam antibodies for SUN1
	Uscn Antibodies for SUN1
	Search ThermoFisher Antibodies for SUN1

Assay Products for SUN1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for SUN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SUN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SUN1 for domains About GeneDecksing

2 InterPro domains/families:

IPR012919 Sad1_UNC_C

IPR018539 RNA-bd_mt

Graphical View of Domain Structure for InterPro Entry O94901

ProtoNet protein and cluster: O94901

1 Blocks protein family: IPB012919 Sad1/UNC-like

UniProtKB/Swiss-Prot: SUN1_HUMAN, O94901

Domain: The SUN domain may play a role in the nuclear anchoring and/or migration

Similarity: Contains 1 SUN domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SUN1_HUMAN, O94901

Function: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the

nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal

filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus

coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome

movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed

for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the

distribution of nuclear pore complexes (NPCs) (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0005521	lamin binding	--	--

SUN1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SUN1:

Increased gamma-H2AX phosphory

7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sun1):

endocrine/exocrine gland	growth/size	homeostasis/metabolism	mortality/aging	muscle
no phenotypic analysis	reproductive system

SUN1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for SUN1: Sun1^tm1Mhan Sun1^tm1.1Ktj

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SUN1

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SUN1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUN1
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate SUN1 (see all 39):
		hsa-miR-142-5p hsa-miR-300 hsa-miR-4272 hsa-miR-25 hsa-miR-29a hsa-miR-1304 hsa-miR-92b hsa-miR-92a

		SwitchGear 3'UTR luciferase reporter plasmid: SUN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUN1 (see all 4) OriGene shRNA RFP: SUN1 OriGene siRNA: SUN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUN1
		Sirion Biotech Custom design and validation of potent shRNA sequences against SUN1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SUN1
			Sirion Biotech Customized adenovirus for overexpression of SUN1 Sirion Biotech Customized adenovirus for potent knockdown of SUN1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUN1 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUN1 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): SUN1 (NM_001130965)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUN1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SUN1
		Search LifeMap BioReagents cell lines for SUN1
		Sirion Biotech Customized stable knockdown cell line services for SUN1 Sirion Biotech Customized inducible knockdown cell line services for SUN1 Sirion Biotech Customized stable overexpressing cell line services for SUN1 Sirion Biotech Customized inducible overexpressing cell line services for SUN1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUN1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Meiotic Synapsis

	Meiotic Synapsis	1.00			Meiosis	0.70
	Telomere clustering at the nuclear membrane	0.82			Chromosome Maintenance	0.56

Cell Cycle

Cell Cycle

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for SUN1

	Meiotic Synapsis
	Cell Cycle
	Meiosis
	Chromosome Maintenance
	Telomere clustering at the nuclear membrane

SUN1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SUN1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/29 Interacting proteins for SUN1 (O94901^{1, 3} ENSP00000384015⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TSNAX	Q99598³, ENSP00000355599⁴	I2D: score=5 STRING: ENSP00000355599
TOLLIP	Q9H0E2³	I2D: score=2
LMNA	P02545³	I2D: score=1
SYNE1	Q8NF91-1¹, ENSP00000265368⁴	EBI-2796904,EBI-6170938 STRING: ENSP00000265368
LMNB1	ENSP00000261366⁴	STRING: ENSP00000261366

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006998	nuclear envelope organization	IGI	16380439
GO:0090286	cytoskeletal anchoring at nuclear membrane	IDA	18396275
GO:0090292	nuclear matrix anchoring at nuclear membrane	IDA	18396275

SUN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SUN1
Search CenterWatch for drugs/clinical trials and news about SUN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SUN1 gene (5 alternative transcripts):

NM_001130965.2 NM_001171944.1 NM_001171945.1 NM_001171946.1 NM_025154.5

Unigene Cluster for SUN1:

Sad1 and UNC84 domain containing 1

Hs.438072 [show with all ESTs]

Unigene Representative Sequence: BC142707

18/37 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 37):

ENST00000427969 ENST00000450538 ENST00000389574 ENST00000435699 ENST00000440380

ENST00000439679 ENST00000424128 ENST00000457598 ENST00000421580 ENST00000340926(uc003sje.1)

ENST00000405266 ENST00000413171 ENST00000401592 ENST00000403868 ENST00000467483

ENST00000483996 ENST00000469755 ENST00000450881

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SUN1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUN1
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate SUN1 (see all 39):
		hsa-miR-142-5p hsa-miR-300 hsa-miR-4272 hsa-miR-25 hsa-miR-29a hsa-miR-1304 hsa-miR-92b hsa-miR-92a

		SwitchGear 3'UTR luciferase reporter plasmid: SUN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUN1 (see all 4) OriGene shRNA RFP: SUN1 OriGene siRNA: SUN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUN1
		Sirion Biotech Custom design and validation of potent shRNA sequences against SUN1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUN1 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SUN1 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): SUN1 (NM_001130965)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUN1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SUN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUN1

Additional cDNA sequence:

AF202724.1 AK022816.1 AK025737.1 AK074320.1 AK302896.1 AK304150.1 AK309120.1 AY776160.1

BC013613.1 BC113916.1 BC142707.1 BX649069.1

24/39 DOTS entries (see all 39):

DT.87016779 DT.101957440 DT.100794357 DT.121644616 DT.100840732 DT.100666045 DT.40229280 DT.121052456

DT.100671866 DT.100794360 DT.408830 DT.97816093 DT.121052442 DT.209433 DT.121052437 DT.91935779

DT.100794355 DT.100794359 DT.121052514 DT.455873 DT.100794352 DT.100794354 DT.121052406 DT.121052512

24/367 AceView cDNA sequences (see all 367):

BX640866 BM988617 BU616362 AA678020 BM689998 BQ890097 BM788609 AI265945

CB306727 BM680057 AA322246 AI886543 CD723301 AA993902 BU685099 BU735855

AI199099 BM830991 CB108072 BM782607 BI335796 CF272438 BX454048 AA598573

GeneLoc Exon Structure

5/29 Alternative Splicing Database (ASD) splice patterns (SP) for SUN1 (see all 29) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	·	13c	·	13d	^	14a	·
SP1:																																							-				-		-		-		-		-
SP2:													-								-		-		-										-		-		-		-		-		-		-		-		-
SP3:																																											-		-				-		-
SP4:
SP5:

ExUns:	14b	^	15a	·	15b	^	16a	·	16b	·	16c	·	16d	·	16e	·	16f	^	17a	·	17b	·	17c	^	18	^	19	^	20	^	21	^	22	^	23a	·	23b	^	24	^	25	^	26a	·	26b	^	27a	·	27b	^	28a	·
SP1:							-		-								-												-														-				-
SP2:	-						-		-								-												-														-				-
SP3:							-		-								-												-														-				-
SP4:																													-														-				-
SP5:																	-												-

ECgene alternative splicing isoforms for SUN1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SUN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGAATATG

About this image
See SUN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SUN1

SOURCE GeneReport for Unigene cluster: Hs.438072
SABiosciences Expression via Pathway-Focused PCR Array including SUN1:

Telomeres & Telomerase in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SUN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SUN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUN1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUN1 gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SUN1¹	Sad1 and UNC84 domain containing 1	64.15(n) 56.28(a)		416449 XM_414757.3 XP_414757.3
lizard (Anolis carolinensis)	Reptilia	-- --	--	68(a) 52(a)	1 ↔ many 1 ↔ many	AAWZ02040058(3418-7422) GL343385.1(674260-681031)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24466²	Xenopus laevis transcribed sequences	79.31(n)		BJ100155.1
zebrafish (Danio rerio)	Actinopterygii	sun1¹	Sad1 and UNC84 domain containing 1	54.6(n) 46.15(a)		553188 NM_001018135.1 NP_001018145.1
fruit fly (Drosophila melanogaster)	Insecta	koi⁶ spag4⁶	sperm-associated antigen 4	25(a) 16(a)	1 ↔ many possible ortholog	2R(2702565-2705704) 2L(11610510-11611772)
worm (Caenorhabditis elegans)	Secernentea	unc-84⁶	Nuclear migration and anchoring protein unc-84	12(a)	1 → many	X(13584705-13589757)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATSUN1⁶ SUN2⁶	SAD1/UNC-84 domain-containing protein 2	19(a) 17(a)	many ↔ many many ↔ many	5(1471481-1473964) 3(3358328-3360682)
rice (Oryza sativa)	Liliopsida	-- --	Sad1 / UNC-like C-terminal domain containing prote... Sad1 / UNC-like C-terminal domain containing prote...	20(a) 20(a)	many ↔ many many ↔ many	1(9178212-9180984) 5(10883292-10886698)

ENSEMBL Gene Tree for SUN1 (if available)
TreeFam Gene Tree for SUN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SUN1 gene

SPAG4² SUN2² SUN3² SUN5²

6 SIMAP similar genes for SUN1 using alignment to 13 protein entries: SUN1_HUMAN (see all proteins):

UNC84A SUN3 SPAG4 SUN2 UNC84B SUN5

SUN1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150644461^1,2		--	853229(+)	`GCGTCC/TGGTCT`	1	--	us2k¹		0	--	--	--	--
rs186897023^1,2		--	853613(+)	`CTCTAC/GTGACA`	1	--	us2k¹		0	--	--	--	--
rs113342852^1,2	C	--	853643(+)	`GGCACG/AGCCAT`	1	--	us2k¹		1		NA	2
rs185111347^1,2		--	853651(+)	`CATCTA/GCCAAA`	1	--	us2k¹		0	--	--	--	--
rs139747264^1,2		--	853655(+)	`TGCCAA/CAATCT`	1	--	us2k¹		0	--	--	--	--
rs149832227^1,2		--	853838(+)	`ACCAGC/TCTGGG`	1	--	us2k¹		0	--	--	--	--
rs6961185^1,2	C	--	853893(+)	`AGGCCG/AAGGCG`	1	--	us2k¹		1		WA	2
rs112136411^1,2	C	--	853923(+)	`AGATCG/AAGACC`	1	--	us2k¹		1		NA	2
rs182580765^1,2		--	853943(+)	`AACACA/GGTGAA`	1	--	us2k¹		0	--	--	--	--
rs184814691^1,2		--	853998(+)	`GCAGGC/TGCCTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SUN1 (855194 - 936072 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SUN1
1 CNV: 99838
5 Indels: 28701 42255 62606 40944 47400

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SUN1 for disorders           About GeneDecksing

OMIM gene information: 607723    OMIM disorders: --

5 diseases for SUN1:    About MalaCards

emery-dreifuss muscular dystrophy muscular dystrophy progeria cerebritis

neuronitis

2 diseases from the University of Copenhagen DISEASES database for SUN1:

Emery-Dreifuss muscular dystrophy Progeria

Human Genome Epidemiology (HuGE) Navigator: SUN1 (4 documents)

Export disorders for SUN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SUN1 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with SUN1)

Utopia: connect your pdf to the dynamic
world of online information

Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. (PubMed id 19933576)^{1, 2} Haque F.... Shackleton S. (2010)
Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. (PubMed id 18396275)^{1, 2} Stewart-Hutchinson P.J.... Hodzic D. (2008)
Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. (PubMed id 17631499)^{1, 2} Chi Y.H....Jeang K.T. (2007)
Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome. (PubMed id 17132086)^{1, 2} Wang Q....Greene M.I. (2006)
Nuclear envelope localization of human UNC84A does not require nuclear lamins. (PubMed id 16445915)^{1, 2} Hasan S....Kutay U. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PubMed id 12958361)^{1, 2} Schirmer E.C....Gerace L. (2003)
Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane. (PubMed id 11593002)^{1, 3} Dreger M....Hucho F. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23353	HGNC: 18587	AceView: UNC84A	Ensembl:ENSG00000164828	euGenes: HUgn23353
ECgene: SUN1	H-InvDB: SUN1

(According to HUGE)
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HUGE: KIAA0810

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SUN1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SUN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SUN1 gene:
Search GeneIP for patents involving SUN1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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