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Aliases for SUN1 Gene

Aliases for SUN1 Gene

  • Sad1 And UNC84 Domain Containing 1 2 3 5
  • Sad1 Unc-84 Domain Protein 1 2 3
  • Sad1/Unc-84 Protein-Like 1 3 4
  • Protein Unc-84 Homolog A 3 4
  • UNC84A 3 4
  • SUN Domain-Containing Protein 1 3
  • Unc-84 Homolog A (C. Elegans) 2
  • Unc-84 Homolog A 3
  • KIAA0810 4

External Ids for SUN1 Gene

Previous HGNC Symbols for SUN1 Gene

  • UNC84A

Previous GeneCards Identifiers for SUN1 Gene

  • GC07P000856
  • GC07P000773

Summaries for SUN1 Gene

Entrez Gene Summary for SUN1 Gene

  • This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2010]

GeneCards Summary for SUN1 Gene

SUN1 (Sad1 And UNC84 Domain Containing 1) is a Protein Coding gene. Diseases associated with SUN1 include Hypertrophy Of Breast and Emery-Dreifuss Muscular Dystrophy. Among its related pathways are Meiosis and Packaging Of Telomere Ends. GO annotations related to this gene include lamin binding. An important paralog of this gene is SUN2.

UniProtKB/Swiss-Prot for SUN1 Gene

  • Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity).

Gene Wiki entry for SUN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUN1 Gene

Genomics for SUN1 Gene

Regulatory Elements for SUN1 Gene

Enhancers for SUN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SUN1 on UCSC Golden Path with GeneCards custom track

Promoters for SUN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUN1 Gene

Chromosome:
7
Start:
815,557 bp from pter
End:
896,435 bp from pter
Size:
80,879 bases
Orientation:
Plus strand

Genomic View for SUN1 Gene

Genes around SUN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUN1 Gene

Proteins for SUN1 Gene

  • Protein details for SUN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94901-SUN1_HUMAN
    Recommended name:
    SUN domain-containing protein 1
    Protein Accession:
    O94901
    Secondary Accessions:
    • A5PL20
    • B3KMV7
    • B4DZF7
    • B7WNY4
    • B7WP53
    • E9PDU4
    • E9PF23
    • F8WD13
    • Q96CZ7
    • Q9HA14
    • Q9UH98

    Protein attributes for SUN1 Gene

    Size:
    812 amino acids
    Molecular mass:
    90064 Da
    Quaternary structure:
    • Dimers and tetramers (By similarity). Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN domain-containing proteins interact with A-type lamins of the nuclear lamina, while at the other end of the complex, nesprins interact with unique cytoskeletal components. May interact with SYNE1, SYNE2 and SYNE3. May interact with SYNE4 (By similarity). Interacts with A-type lamin with a strong preference for unprocessed A-type lamin compared with the mature protein. Interaction with lamins B1 and C is hardly detectable. Interacts with TSNAX (By similarity). Interacts with EMD and NAT10. Associates with the nuclear pore complex (NPC) (By similarity). Interacts with CCDC155 (via the last 22 AA); this interaction mediates CCDC155 telomere localization. Interacts with CCDC79/TERB1; promoting the accumulation of the LINC complex complexes at the telomere-nuclear envelope attachment sites (By similarity).
    SequenceCaution:
    • Sequence=BAA34530.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SUN1 Gene

neXtProt entry for SUN1 Gene

Post-translational modifications for SUN1 Gene

  • Ubiquitination at Lys 195, Lys 367, Lys 419, Lys 523, and Lys 699
  • Glycosylation at Asn 588
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SUN1 Gene

Domains & Families for SUN1 Gene

Protein Domains for SUN1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SUN1 Gene

Graphical View of Domain Structure for InterPro Entry

O94901

UniProtKB/Swiss-Prot:

SUN1_HUMAN :
  • The SUN domain may play a role in the nuclear anchoring and/or migration.
Domain:
  • The SUN domain may play a role in the nuclear anchoring and/or migration.
  • Contains 1 SUN domain.
genes like me logo Genes that share domains with SUN1: view

No data available for Gene Families for SUN1 Gene

Function for SUN1 Gene

Molecular function for SUN1 Gene

UniProtKB/Swiss-Prot Function:
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity).

Gene Ontology (GO) - Molecular Function for SUN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18396275
GO:0005521 lamin binding IEA --
genes like me logo Genes that share ontologies with SUN1: view
genes like me logo Genes that share phenotypes with SUN1: view

Animal Models for SUN1 Gene

MGI Knock Outs for SUN1:

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUN1 Gene

Localization for SUN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUN1 Gene

Nucleus inner membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUN1 Gene COMPARTMENTS Subcellular localization image for SUN1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SUN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IDA 19933576
GO:0005639 integral component of nuclear inner membrane IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SUN1: view

Pathways & Interactions for SUN1 Gene

SuperPathways for SUN1 Gene

genes like me logo Genes that share pathways with SUN1: view

Pathways by source for SUN1 Gene

3 Reactome pathways for SUN1 Gene

Gene Ontology (GO) - Biological Process for SUN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0006998 nuclear envelope organization IGI 16380439
GO:0007129 synapsis IEA --
GO:0009612 response to mechanical stimulus IEA --
GO:0090286 cytoskeletal anchoring at nuclear membrane IDA 18396275
genes like me logo Genes that share ontologies with SUN1: view

No data available for SIGNOR curated interactions for SUN1 Gene

Drugs & Compounds for SUN1 Gene

No Compound Related Data Available

Transcripts for SUN1 Gene

Unigene Clusters for SUN1 Gene

Sad1 and UNC84 domain containing 1:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a ·
SP1: - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - -
SP4:
SP5:
SP6: - - - - - -
SP7:
SP8: - - - - - - - - - - - - - -
SP9: - - - - -
SP10: - -
SP11: - -
SP12: - -
SP13: - - - - -
SP14: - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - -
SP17: - -
SP18:
SP19: - - - -
SP20: - - - - - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - - - - - - -
SP22:
SP23:
SP24: -
SP25:
SP26: -
SP27:
SP28: -
SP29:

ExUns: 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d · 16e · 16f ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6:
SP7: - - -
SP8: -
SP9:
SP10:
SP11: - - -
SP12: - - -
SP13:
SP14:
SP15:
SP16: - -
SP17: - -
SP18: - -
SP19:
SP20: -
SP21: - - -
SP22:
SP23: - -
SP24:
SP25: -
SP26:
SP27: -
SP28:
SP29:

Relevant External Links for SUN1 Gene

GeneLoc Exon Structure for
SUN1
ECgene alternative splicing isoforms for
SUN1

Expression for SUN1 Gene

mRNA expression in normal human tissues for SUN1 Gene

Protein differential expression in normal tissues from HIPED for SUN1 Gene

This gene is overexpressed in Nasal epithelium (30.0) and Testis (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUN1 Gene



Protein tissue co-expression partners for SUN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SUN1 Gene:

SUN1

SOURCE GeneReport for Unigene cluster for SUN1 Gene:

Hs.438072
genes like me logo Genes that share expression patterns with SUN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SUN1 Gene

Orthologs for SUN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUN1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SUN1 34
  • 77.16 (n)
  • 73.78 (a)
SUN1 35
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sun1 34
  • 73.99 (n)
  • 70.8 (a)
Sun1 16
Sun1 35
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUN1 34
  • 98.98 (n)
  • 98.47 (a)
SUN1 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sun1 34
  • 74.43 (n)
  • 70.39 (a)
cow
(Bos Taurus)
Mammalia SUN1 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUN1 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUN1 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUN1 34
  • 64.68 (n)
  • 57.34 (a)
SUN1 35
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 71 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sun1 34
  • 58.17 (n)
  • 50.6 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24466 34
zebrafish
(Danio rerio)
Actinopterygii sun1 34
  • 54.09 (n)
  • 46.08 (a)
sun1 35
  • 34 (a)
OneToMany
SUN1 (2 of 2) 35
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta koi 35
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-84 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for SUN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUN1 Gene

ENSEMBL:
Gene Tree for SUN1 (if available)
TreeFam:
Gene Tree for SUN1 (if available)

Paralogs for SUN1 Gene

Paralogs for SUN1 Gene

genes like me logo Genes that share paralogs with SUN1: view

Variants for SUN1 Gene

Sequence variations from dbSNP and Humsavar for SUN1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6461378 - 842,031(+) TCAGC(C/T)ACGGC reference, missense
rs144929525 - 843,470(+) CCCCG(C/T)GGCCC intron-variant, reference, missense
VAR_071066 -
rs7790118 -- 860,912(+) agcac(A/G)ggaga intron-variant
rs7790249 -- 866,561(+) CCCCG(G/T)ACCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUN1 Gene

Variant ID Type Subtype PubMed ID
dgv11111n54 CNV loss 21841781
dgv3465n106 CNV deletion 24896259
esv1137257 CNV insertion 17803354
esv1171001 CNV insertion 17803354
esv1417298 CNV deletion 17803354
esv1504158 CNV insertion 17803354
esv1640628 CNV insertion 17803354
esv2208128 CNV deletion 18987734
esv2485286 CNV deletion 19546169
esv2661195 CNV deletion 23128226
esv2733668 CNV deletion 23290073
esv2733669 CNV deletion 23290073
esv2733670 CNV deletion 23290073
esv275281 CNV gain+loss 21479260
esv3095255 CNV deletion 24192839
esv3281940 CNV deletion 24192839
esv3541001 CNV deletion 23714750
esv3541002 CNV deletion 23714750
esv3541003 CNV deletion 23714750
esv3571557 CNV loss 25503493
esv3611789 CNV loss 21293372
esv3611790 CNV loss 21293372
esv3611791 CNV loss 21293372
esv3611792 CNV loss 21293372
esv5081 CNV loss 18987735
esv5578 CNV loss 19470904
esv994061 CNV deletion 20482838
esv997325 CNV deletion 20482838
nsv1021075 CNV gain 25217958
nsv1074465 CNV deletion 25765185
nsv1074466 CNV deletion 25765185
nsv1124155 CNV deletion 24896259
nsv1147635 CNV deletion 26484159
nsv464244 CNV loss 19166990
nsv475669 CNV novel sequence insertion 20440878
nsv823957 CNV gain 20364138
nsv950784 CNV deletion 24416366
nsv955963 CNV deletion 24416366

Variation tolerance for SUN1 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.52; 77.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUN1 Gene

Human Gene Mutation Database (HGMD)
SUN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUN1 Gene

Disorders for SUN1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SUN1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypertrophy of breast
  • breasts enlarged
emery-dreifuss muscular dystrophy
  • edmd
- elite association - COSMIC cancer census association via MalaCards
Search SUN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SUN1

Human Genome Epidemiology (HuGE) Navigator
SUN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUN1
genes like me logo Genes that share disorders with SUN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUN1 Gene

Publications for SUN1 Gene

  1. Contribution of SUN1 mutations to the pathomechanism in muscular dystrophies. (PMID: 24375709) Li P. … Noegel A.A. (Hum. Mutat. 2014) 3 4 65
  2. Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. (PMID: 19933576) Haque F. … Shackleton S. (J. Biol. Chem. 2010) 3 4 65
  3. Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. (PMID: 18396275) Stewart-Hutchinson P.J. … Hodzic D. (Exp. Cell Res. 2008) 3 4 65
  4. Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. (PMID: 17631499) Chi Y.-H. … Jeang K.-T. (J. Biol. Chem. 2007) 3 4 65
  5. Nuclear envelope localization of human UNC84A does not require nuclear lamins. (PMID: 16445915) Hasan S. … Kutay U. (FEBS Lett. 2006) 3 4 65

Products for SUN1 Gene

Sources for SUN1 Gene

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