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Aliases for SUN1 Gene

Aliases for SUN1 Gene

  • Sad1 And UNC84 Domain Containing 1 2 3
  • UNC84A 3 4 6
  • Sad1 Unc-84 Domain Protein 1 2 3
  • Sad1/Unc-84 Protein-Like 1 3 4
  • Protein Unc-84 Homolog A 3 4
  • SUN Domain-Containing Protein 1 3
  • Unc-84 Homolog A (C. Elegans) 2
  • Unc-84 Homolog A 3
  • KIAA0810, 6
  • KIAA0810 4

External Ids for SUN1 Gene

Previous HGNC Symbols for SUN1 Gene

  • UNC84A

Previous GeneCards Identifiers for SUN1 Gene

  • GC07P000856
  • GC07P000773

Summaries for SUN1 Gene

Entrez Gene Summary for SUN1 Gene

  • This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2010]

GeneCards Summary for SUN1 Gene

SUN1 (Sad1 And UNC84 Domain Containing 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Meiosis. GO annotations related to this gene include lamin binding. An important paralog of this gene is SUN5.

UniProtKB/Swiss-Prot for SUN1 Gene

  • Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity).

Gene Wiki entry for SUN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUN1 Gene

Genomics for SUN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUN1 Gene

Start:
815,557 bp from pter
End:
896,435 bp from pter
Size:
80,879 bases
Orientation:
Plus strand

Genomic View for SUN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUN1 Gene

No data available for Regulatory Elements for SUN1 Gene

Proteins for SUN1 Gene

  • Protein details for SUN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94901-SUN1_HUMAN
    Recommended name:
    SUN domain-containing protein 1
    Protein Accession:
    O94901
    Secondary Accessions:
    • A5PL20
    • B3KMV7
    • B4DZF7
    • B7WNY4
    • B7WP53
    • E9PDU4
    • E9PF23
    • F8WD13
    • Q96CZ7
    • Q9HA14
    • Q9UH98

    Protein attributes for SUN1 Gene

    Size:
    812 amino acids
    Molecular mass:
    90064 Da
    Quaternary structure:
    • Dimers and tetramers (By similarity). Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN domain-containing proteins interact with A-type lamins of the nuclear lamina, while at the other end of the complex, nesprins interact with unique cytoskeletal components. May interact with SYNE1, SYNE2 and SYNE3. May interact with SYNE4 (By similarity). Interacts with A-type lamin with a strong preference for unprocessed A-type lamin compared with the mature protein. Interaction with lamins B1 and C is hardly detectable. Interacts with TSNAX (By similarity). Interacts with EMD and NAT10. Associates with the nuclear pore complex (NPC) (By similarity). Interacts with CCDC155 (via the last 22 AA); this interaction mediates CCDC155 telomere localization. Interacts with CCDC79/TERB1; promoting the accumulation of the LINC complex complexes at the telomere-nuclear envelope attachment sites (By similarity).
    SequenceCaution:
    • Sequence=BAA34530.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SUN1 Gene

neXtProt entry for SUN1 Gene

Proteomics data for SUN1 Gene at MOPED

Post-translational modifications for SUN1 Gene

  • Ubiquitination at Lys195, Lys367, Lys419, Lys523, and Lys699
  • Glycosylation at Asn588
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SUN1 Gene

Domains for SUN1 Gene

Protein Domains for SUN1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SUN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94901

UniProtKB/Swiss-Prot:

SUN1_HUMAN :
  • O94901
Domain:
  • The SUN domain may play a role in the nuclear anchoring and/or migration.
  • Contains 1 SUN domain.
genes like me logo Genes that share domains with SUN1: view

No data available for Gene Families for SUN1 Gene

Function for SUN1 Gene

Molecular function for SUN1 Gene

UniProtKB/Swiss-Prot Function: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity).

Gene Ontology (GO) - Molecular Function for SUN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18396275
GO:0005521 lamin binding IEA --
genes like me logo Genes that share ontologies with SUN1: view
genes like me logo Genes that share phenotypes with SUN1: view

Animal Models for SUN1 Gene

MGI Knock Outs for SUN1:

Animal Model Products

CRISPR Products

miRNA for SUN1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUN1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SUN1 Gene

Localization for SUN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUN1 Gene

Nucleus inner membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUN1 Gene COMPARTMENTS Subcellular localization image for SUN1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SUN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005634 nucleus --
GO:0005635 nuclear envelope IDA 19933576
GO:0005639 integral component of nuclear inner membrane IEA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with SUN1: view

Pathways for SUN1 Gene

genes like me logo Genes that share pathways with SUN1: view

Pathways by source for SUN1 Gene

4 Reactome pathways for SUN1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SUN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IGI 16380439
GO:0090286 cytoskeletal anchoring at nuclear membrane IDA 18396275
GO:0090292 nuclear matrix anchoring at nuclear membrane IDA 18396275
genes like me logo Genes that share ontologies with SUN1: view

Transcripts for SUN1 Gene

Unigene Clusters for SUN1 Gene

Sad1 and UNC84 domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUN1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SUN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a ·
SP1: - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - -
SP4:
SP5:
SP6: - - - - - -
SP7:
SP8: - - - - - - - - - - - - - -
SP9: - - - - -
SP10: - -
SP11: - -
SP12: - -
SP13: - - - - -
SP14: - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - -
SP17: - -
SP18:
SP19: - - - -
SP20: - - - - - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - - - - - - -
SP22:
SP23:
SP24: -
SP25:
SP26: -
SP27:
SP28: -
SP29:

ExUns: 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d · 16e · 16f ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6:
SP7: - - -
SP8: -
SP9:
SP10:
SP11: - - -
SP12: - - -
SP13:
SP14:
SP15:
SP16: - -
SP17: - -
SP18: - -
SP19:
SP20: -
SP21: - - -
SP22:
SP23: - -
SP24:
SP25: -
SP26:
SP27: -
SP28:
SP29:

Relevant External Links for SUN1 Gene

GeneLoc Exon Structure for
SUN1
ECgene alternative splicing isoforms for
SUN1

Expression for SUN1 Gene

mRNA expression in normal human tissues for SUN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUN1 Gene

SOURCE GeneReport for Unigene cluster for SUN1 Gene Hs.438072

genes like me logo Genes that share expressions with SUN1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SUN1 Gene

Orthologs for SUN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUN1 35
  • 98.98 (n)
  • 98.47 (a)
SUN1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUN1 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUN1 35
  • 77.16 (n)
  • 73.78 (a)
SUN1 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sun1 35
  • 73.99 (n)
  • 70.8 (a)
Sun1 16
Sun1 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SUN1 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUN1 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sun1 35
  • 74.43 (n)
  • 70.39 (a)
chicken
(Gallus gallus)
Aves SUN1 35
  • 64.68 (n)
  • 57.34 (a)
SUN1 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 71 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.24466 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sun1 35
  • 58.17 (n)
  • 50.6 (a)
zebrafish
(Danio rerio)
Actinopterygii sun1 35
  • 54.09 (n)
  • 46.08 (a)
sun1 36
  • 34 (a)
OneToMany
SUN1 (2 of 2) 36
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta koi 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-84 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for SUN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUN1 Gene

ENSEMBL:
Gene Tree for SUN1 (if available)
TreeFam:
Gene Tree for SUN1 (if available)

Paralogs for SUN1 Gene

Paralogs for SUN1 Gene

genes like me logo Genes that share paralogs with SUN1: view

Variants for SUN1 Gene

Sequence variations from dbSNP and Humsavar for SUN1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1779 -- 867,102(+) ATCAC(A/G)TGGGA intron-variant
rs1127460 -- 839,130(+) ACCTG(C/T)CATAT intron-variant
rs4076072 -- 853,265(+) TGATA(C/T)TCCGG intron-variant
rs4130000 -- 850,414(-) AGACC(A/G)TCCTG intron-variant
rs4236291 -- 832,288(+) TATAT(G/T)AGGGG upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUN1 Gene

Variant ID Type Subtype PubMed ID
dgv7074n71 CNV Loss 21882294
dgv7078n71 CNV Loss 21882294
nsv887128 CNV Loss 21882294
nsv887134 CNV Loss 21882294
esv2733668 CNV Deletion 23290073
esv1640628 CNV Insertion 17803354
esv2661195 CNV Deletion 23128226
esv2485286 CNV Deletion 19546169
esv2208128 CNV Deletion 18987734
esv2733669 CNV Deletion 23290073
esv994061 CNV Deletion 20482838
esv5081 CNV Deletion 18987735
esv997325 CNV Deletion 20482838
esv1417298 CNV Deletion 17803354
esv5578 CNV Loss 19470904
esv275281 CNV Gain+Loss 21479260
nsv887135 CNV Loss 21882294
esv1504158 CNV Insertion 17803354
esv2733670 CNV Deletion 23290073
esv1137257 CNV Insertion 17803354
dgv7080n71 CNV Loss 21882294
esv1171001 CNV Insertion 17803354
nsv464244 CNV Loss 19166990
nsv823957 CNV Gain 20364138

Relevant External Links for SUN1 Gene

HapMap Linkage Disequilibrium report
SUN1
Human Gene Mutation Database (HGMD)
SUN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUN1 Gene

Disorders for SUN1 Gene

(2) University of Copenhagen DISEASES for SUN1 Gene

Relevant External Links for SUN1

Human Genome Epidemiology (HuGE) Navigator
SUN1
genes like me logo Genes that share disorders with SUN1: view

No data available for UniProtKB/Swiss-Prot for SUN1 Gene

Publications for SUN1 Gene

  1. Contribution of SUN1 mutations to the pathomechanism in muscular dystrophies. (PMID: 24375709) Li P. … Noegel A.A. (Hum. Mutat. 2014) 3 4
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development. (PMID: 10375507) Malone C.J. … Han M. (Development 1999) 3 4
  4. Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. (PMID: 19933576) Haque F. … Shackleton S. (J. Biol. Chem. 2010) 3 4
  5. Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. (PMID: 17631499) Chi Y.-H. … Jeang K.-T. (J. Biol. Chem. 2007) 3 4

Products for SUN1 Gene

Sources for SUN1 Gene

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