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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUMO4 Gene

protein-coding   GIFtS: 57
GCID: GC06P149763

Small Ubiquitin-Like Modifier 4

(Previous names: SMT3 suppressor of mif two 3 homolog 4 (yeast), SMT3 suppressor...)
(Previous symbol: SMT3H4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Small Ubiquitin-Like Modifier 41 2     dJ281H8.42
SMT3H41 2 3     Small Ubiquitin-Like Modifier 4 Protein2
SUMO-42 3     Small Ubiquitin-Related Modifier 42
IDDM52 5     SMT3 Suppressor Of Mif Two 3 Homolog 22
SMT3 Suppressor Of Mif Two 3 Homolog 4 (S. Cerevisiae)1     SMT3 Suppressor Of Mif Two 3 Homolog 42
SMT3 Suppressor Of Mif Two 3 Homolog 4 (Yeast)1     Small Ubiquitin-Like Protein 43

External Ids:    HGNC: 211811   Entrez Gene: 3870822   Ensembl: ENSG000001776887   OMIM: 6088295   UniProtKB: Q6EEV63   

Export aliases for SUMO4 gene to outside databases

Previous GC identifers: GC06U900642 GC0XM114776 GC06P147288


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUMO4 Gene:
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that
are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The
protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative
regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene,
which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this
polymorphism. (provided by RefSeq, Jul 2008)

GeneCards Summary for SUMO4 Gene: 
SUMO4 (small ubiquitin-like modifier 4) is a protein-coding gene. Diseases associated with SUMO4 include diabetes mellitus, insulin-dependent, 5, and behcet's disease. GO annotations related to this gene include SUMO ligase activity. An important paralog of this gene is SUMO2.

UniProtKB/Swiss-Prot: SUMO4_HUMAN, Q6EEV6
Function: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to
be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon
oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also
conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1,
positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior
activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I

Gene Wiki entry for SUMO4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUMO4 gene promoter:
         GR   AP-2alpha isoform 3   AML1a   AP-2alpha isoform 2   GATA-1   PPAR-alpha   GR-alpha   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SUMO4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUMO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25.1

SUMO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUMO4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P149763:  view genomic region     (about GC identifiers)

Start:
149,721,495 bp from pter      End:
149,722,182 bp from pter
Size:
688 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SUMO4_HUMAN, Q6EEV6 (See protein sequence)
Recommended Name: Small ubiquitin-related modifier 4 precursor  
Size: 95 amino acids; 10685 Da
Subunit: Interacts with SAE2. Covalently attached to a number of proteins (Probable)
Secondary accessions: A1L3W5

Explore the universe of human proteins at neXtProt for SUMO4: NX_Q6EEV6

Explore proteomics data for SUMO4 at MOPED 

Post-translational modifications:

  • UniProtKB: In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence
    of Pro-90. This may impair processing to mature form and conjugation to substrates
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6EEV6

  • SUMO4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SUMO4 Protein Expression
    REFSEQ proteins: NP_001002255.1  
    ENSEMBL proteins: 
     ENSP00000318635  

    Human Recombinant Protein Products for SUMO4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SUMO4
    GenScript Custom Purified and Recombinant Proteins Services for SUMO4
    Novus Biologicals SUMO4 Protein
    Novus Biologicals SUMO4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SUMO4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    SUMO4 for ontologies           About GeneDecksing



    SUMO4 Antibody Products: 
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    Novus Biologicals SUMO4 Antibodies
    Abcam antibodies for SUMO4
    Cloud-Clone Corp. Antibodies for SUMO4 
    ThermoFisher Antibodies for SUMO4
    LSBio Antibodies in human, mouse, rat for SUMO4 

    Assay Products for SUMO4: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SUMO4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SUMO4 
    Cloud-Clone Corp. CLIAs for SUMO4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR022617 SUMO
     IPR027218 SUMO_chordates
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry Q6EEV6

    ProtoNet protein and cluster: Q6EEV6

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: SUMO4_HUMAN, Q6EEV6
    Similarity: Belongs to the ubiquitin family. SUMO subfamily
    Similarity: Contains 1 ubiquitin-like domain


    SUMO4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUMO4_HUMAN, Q6EEV6
    Function: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to
    be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon
    oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also
    conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1,
    positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior
    activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SUMO4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SUMO4:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SUMO4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUMO4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUMO4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUMO4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUMO4
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    SwitchGear 3'UTR luciferase reporter plasmidSUMO4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SUMO4
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SUMO4

    Clone
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    Sino Biological Human cDNA Clone for SUMO4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUMO4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUMO4
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                         Customized lentivirus expression plasmids for stable overexpression of SUMO4 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SUMO4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for SUMO4):
        RNA transport


    SUMO4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SUMO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/120 Interacting proteins for SUMO4 (Q6EEV63 ENSP000003186354) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232804P081073, ENSP000003930874I2D: score=1 STRING: ENSP00000393087
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016925protein sumoylation IEA--

    SUMO4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SUMO4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUMO4

    2 Novoseek inferred chemical compound relationships for SUMO4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    valine 36.4 4 15730420 (3), 15123604 (1)
    methionine 24.2 2 15730420 (1), 15123604 (1)

    Search CenterWatch for drugs/clinical trials and news about SUMO4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUMO4 gene: 
    NM_001002255.1  

    Unigene Cluster for SUMO4:

    SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
    Hs.657168  [show with all ESTs]
    Unigene Representative Sequence: AY340238
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000326669(uc003qml.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUMO4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SUMO4
    SwitchGear 3'UTR luciferase reporter plasmidSUMO4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SUMO4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUMO4
    Clone
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    OriGene clones in human, mouse for SUMO4 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: SUMO4 (NM_001002255)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUMO4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUMO4
    Sirion Biotech Customized lentivirus for stable overexpression of SUMO4 
                         Customized lentivirus expression plasmids for stable overexpression of SUMO4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SUMO4
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUMO4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUMO4

    Additional mRNA sequence: 

    AY340238.1 BC130305.1 

    1 DOTS entry:

    DT.91998796 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUMO4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTAACTGG
    SUMO4 Expression
    About this image


    See SUMO4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUMO4

    SOURCE GeneReport for Unigene cluster: Hs.657168

    UniProtKB/Swiss-Prot: SUMO4_HUMAN, Q6EEV6
    Tissue specificity: Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues,
    with the highest expression in the lymph node and spleen

        SABiosciences Custom PCR Arrays for SUMO4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SUMO4 gene from 6/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    SUMO46
    --
    SMT3 suppressor of mif two 3 homolog 4 (S. cerevis...
    59(a)
    56(a)
    possible ortholog
    1 ↔ 1
    12(33289851-33290448)
    3(83842292-83842669)
    chicken
    (Gallus gallus)
    Aves SUMO26
    Small ubiquitin-related modifier 2
    85(a)
    1 → many
    18(10947891-10954469)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    85(a)
    1 → many
    2(114742718-114750546)
    zebrafish
    (Danio rerio)
    Actinopterygii sumo2a6
    SMT3 suppressor of mif two 3 homolog 2a
    61(a)
    1 → many
    6(18686358-18692065)
    fruit fly
    (Drosophila melanogaster)
    Insecta smt36
    smt3
    61(a)
    1 → many
    2L(6966780-6967644)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMT36
    Ubiquitin-like protein of the SUMO family, conjuga...
    36(a)
    1 → many
    IV(1469400-1469705)


    ENSEMBL Gene Tree for SUMO4 (if available)
    TreeFam Gene Tree for SUMO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUMO4 gene
    SUMO22  ENSG000002285322  SUMO12  SUMO32  
    4 SIMAP similar genes for SUMO4 using alignment to 1 protein entry:     SUMO4_HUMAN:
    SUMO2    SUMO3    NFATC2IP    SUMO1

    SUMO4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: SUMO4_HUMAN, Q6EEV6
    Polymorphism: Variant Val-55 could be associated with insulin-dependent diabetes mellitus 5 (IDDM5) [MIM:600320]


    10/85 SNPs in SUMO4 are shown (see all 85)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2370251,2,4
    C,F,A,Hother1149721310(-) CTTCAT/CTGACA 2 /M /V mis1 ese331Minor allele frequency- C:0.41MN NS EA NA WA CSA EU 8831
    rs1382780291,2
    --149719238(+) TAACCA/CAAAGA 1 -- us2k10--------
    rs2370271,2
    C,F,A,H--149719523(-) TAAACG/AATCAA 1 -- us2k195Minor allele frequency- A:0.10NS EA NA PA EU CA WA 5016
    rs7635901,2
    C,F,A,H--149719587(+) CAGGGA/TTCTAC 1 -- us2k114Minor allele frequency- T:0.16NA EA NS WA CSA 1038
    rs1824948241,2
    --149719690(+) ATAATA/GTATTT 1 -- us2k10--------
    rs358008351,2
    C,F--149719720(+) TACATA/GTAATT 1 -- us2k13Minor allele frequency- G:0.01NS NA 214
    rs345909711,2
    C,F--149719734(+) GGTTAG/CAGGGG 1 -- us2k15Minor allele frequency- C:0.04NS WA CSA 216
    rs347277711,2
    C,F--149719754(+) TGAAAA/GGCATT 1 -- us2k13Minor allele frequency- G:0.02NS NA 214
    rs1871857931,2
    --149719765(+) TCTTAC/TAGCGT 1 -- us2k10--------
    rs360710261,2
    C,F--149719768(+) TATAGC/AGTGTT 1 -- us2k12Minor allele frequency- A:0.01NS 94

    HapMap Linkage Disequilibrium report for SUMO4 (149721495 - 149722182 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SUMO4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522875CNV Loss19592680


    Human Gene Mutation Database (HGMD): SUMO4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SUMO4
    DNA2.0 Custom Variant and Variant Library Synthesis for SUMO4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608829   
    OMIM disorders: 600320  
    14 diseases for SUMO4:    About MalaCards
    diabetes mellitus, insulin-dependent, 5    behcet's disease    autoimmune thyroiditis    graves' disease
    diabetes mellitus    diabetic retinopathy    rheumatoid arthritis    coronary heart disease
    type 1 diabetes    psoriasis    systemic lupus erythematosus    arthritis
    lupus erythematosus    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for SUMO4:
    Diabetes mellitus

    SUMO4 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for SUMO4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune thyroid disease 62.7 1 16735488 (1)
    diabetes autoimmune 53.2 1 16735488 (1)
    autoimmunity 50.7 1 17374705 (1)
    diabetes mellitus insulin-dependent 46.9 4 15730420 (1), 15123604 (1), 17130563 (1)
    autoimmune diseases 46.3 5 16735488 (2), 17459725 (1), 19956095 (1), 16821265 (1)
    genetic susceptibility 40.5 1 16735488 (1)
    rheumatoid arthritis 21.2 4 16821265 (2), 16735488 (1), 16159953 (1)

    Genetic Association Database (GAD): SUMO4
    Human Genome Epidemiology (HuGE) Navigator: SUMO4 (30 documents)

    Export disorders for SUMO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUMO4 gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with SUMO4)
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    1. A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. (PubMed id 15123604)1, 2, 3, 4, 9 Bohren K.M.... Owerbach D. (2004)
    2. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. (PubMed id 15247916)1, 2, 4, 9 Guo D.... Wang C.-Y. (2004)
    3. Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. (PubMed id 15678135)1, 2, 4 Qu H.... Polychronakos C. (2005)
    4. A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes. (PubMed id 17926234)1, 4, 9 Rudofsky G....Hamann A. (2008)
    5. Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations. (PubMed id 17130530)1, 4, 9 Noso S....Ogihara T. (2006)
    6. The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis. (PubMed id 16159953)1, 4, 9 Gibbons L.J....Hinks A. (2005)
    7. Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population. (PubMed id 17374705)1, 4, 9 Noso S....Ikegami H. (2007)
    8. SLC22A4, RUNX1, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: a case-control study in a Spanish population. (PubMed id 16821265)1, 4, 9 Orozco G....Martin J. (2006)
    9. No association of the codon 55 methionine to valine polymorphism in the SUMO4 gene with Graves' disease. (PubMed id 15730420)1, 4, 9 Jennings C.E....Pearce S.H. (2005)
    10. SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes. (PubMed id 17229939)1, 4, 9 Lin H.Y....Shin S.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 387082 HGNC: 21181 Ensembl:ENSG00000177688 euGenes: HUgn387082 ECgene: SUMO4 Kegg: 387082
    H-InvDB: SUMO4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUMO4 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/SUMO_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUMO4 gene:
    Search GeneIP for patents involving SUMO4

    GeneCards and IP:
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