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SUMO4 Gene

protein-coding   GIFtS: 58
GCID: GC06P149763

Small Ubiquitin-Like Modifier 4

(Previous names: SMT3 suppressor of mif two 3 homolog 4 (yeast), SMT3 suppressor...)
(Previous symbols: SMT3H4, IDDM5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Small Ubiquitin-Like Modifier 41 2     dJ281H8.42
SMT3H41 2 3     Small Ubiquitin-Like Modifier 4 Protein2
IDDM51 2 5     Small Ubiquitin-Related Modifier 42
Insulin-Dependent Diabetes Mellitus 51 2     SMT3 Suppressor Of Mif Two 3 Homolog 22
SUMO-42 3     SMT3 Suppressor Of Mif Two 3 Homolog 42
SMT3 Suppressor Of Mif Two 3 Homolog 4 (S. Cerevisiae)1     Small Ubiquitin-Like Protein 43
SMT3 Suppressor Of Mif Two 3 Homolog 4 (Yeast)1     

External Ids:    HGNC: 211811   Entrez Gene: 3870822   Ensembl: ENSG000001776887   OMIM: 6088295   UniProtKB: Q6EEV63   

Export aliases for SUMO4 gene to outside databases

Previous GC identifers: GC06U900642 GC0XM114776 GC06P147288


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SUMO4 Gene:
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that
are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The
protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative
regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene,
which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this
polymorphism. (provided by RefSeq, Jul 2008)

GeneCards Summary for SUMO4 Gene:
SUMO4 (small ubiquitin-like modifier 4) is a protein-coding gene. Diseases associated with SUMO4 include diabetes mellitus, insulin-dependent, 5, and autoimmune thyroiditis. An important paralog of this gene is SUMO2.

UniProtKB/Swiss-Prot: SUMO4_HUMAN, Q6EEV6
Function: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to
be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon
oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also
conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1,
positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior
activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I

Gene Wiki entry for SUMO4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUMO4 gene promoter:
         GR   AP-2alpha isoform 3   AML1a   AP-2alpha isoform 2   GATA-1   PPAR-alpha   GR-alpha   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SUMO4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUMO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25.1

SUMO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUMO4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P149763:  view genomic region     (about GC identifiers)

Start:
149,721,495 bp from pter      End:
149,722,182 bp from pter
Size:
688 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SUMO4_HUMAN, Q6EEV6 (See protein sequence)
Recommended Name: Small ubiquitin-related modifier 4 precursor  
Size: 95 amino acids; 10685 Da
Subunit: Interacts with SAE2. Covalently attached to a number of proteins (Probable)
Secondary accessions: A1L3W5

Explore the universe of human proteins at neXtProt for SUMO4: NX_Q6EEV6

Explore proteomics data for SUMO4 at MOPED

Post-translational modifications: 

  • In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence
    of Pro-90. This may impair processing to mature form and conjugation to substrates1
  • Ubiquitination2 at Lys33, Lys35
  • Modification sites at PhosphoSitePlus

  • See SUMO4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001002255.1  
    ENSEMBL proteins: 
     ENSP00000318635  

    SUMO4 Human Recombinant Protein Products:

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    Novus Biologicals SUMO4 Protein
    Novus Biologicals SUMO4 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SUMO4

    SUMO4 Antibody Products:

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    SUMO4 Assay Products:

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    Cloud-Clone Corp. CLIAs for SUMO4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR022617 Rad60/SUMO_like
     IPR027218 SUMO_chordates
     IPR000626 Ubiquitin_dom

    Graphical View of Domain Structure for InterPro Entry Q6EEV6

    ProtoNet protein and cluster: Q6EEV6

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: SUMO4_HUMAN, Q6EEV6
    Similarity: Belongs to the ubiquitin family. SUMO subfamily
    Similarity: Contains 1 ubiquitin-like domain


    SUMO4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUMO4_HUMAN, Q6EEV6
    Function: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to
    be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon
    oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also
    conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1,
    positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior
    activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SUMO4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SUMO4:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

    Animal Models:
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUMO4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    SUMO4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SUMO4 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for SUMO4):
        RNA transport


    SUMO4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SUMO4
    Interactions:

        GeneGlobe Interaction Network for SUMO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUMO4 (Q6EEV63 ENSP000003186354) via UniProtKB, MINT, STRING, and/or I2D (see all 221)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232804P081073, ENSP000003930874I2D: score=1 STRING: ENSP00000393087
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016925protein sumoylation IEA--

    SUMO4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUMO4

    2 Novoseek inferred chemical compound relationships for SUMO4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    valine 36.4 4 15730420 (3), 15123604 (1)
    methionine 24.2 2 15730420 (1), 15123604 (1)



    SUMO4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SUMO4 gene: 
    NM_001002255.1  

    Unigene Cluster for SUMO4:

    SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
    Hs.657168  [show with all ESTs]
    Unigene Representative Sequence: AY340238
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000326669(uc003qml.3)
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    Additional mRNA sequence: 

    AY340238.1 BC130305.1 

    1 DOTS entry:

    DT.91998796 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SUMO4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTAACTGG
    SUMO4 Expression
    About this image


    SUMO4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
    SUMO4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUMO4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657168

    UniProtKB/Swiss-Prot: SUMO4_HUMAN, Q6EEV6
    Tissue specificity: Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues,
    with the highest expression in the lymph node and spleen

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SUMO4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SUMO26
    Gallus gallus SMT3 suppressor of mif two 3 homolog...
    85(a)
    1 → many
    18(10947891-10954469)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    85(a)
    1 → many
    2(114742718-114750546)
    zebrafish
    (Danio rerio)
    Actinopterygii sumo2b6
    SMT3 suppressor of mif two 3 homolog 2b
    81(a)
    1 → many
    3(6945637-6963972) ENSDARG00000046062
    fruit fly
    (Drosophila melanogaster)
    Insecta smt36
    smt3
    62(a)
    1 → many
    2L(6966780-6967644)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMT36
    Ubiquitin-like protein of the SUMO family, conjuga...
    36(a)
    1 → many
    IV(1469400-1469705) YDR510W
            Species with no ortholog for SUMO4

    ENSEMBL Gene Tree for SUMO4 (if available)
    TreeFam Gene Tree for SUMO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUMO4 gene
    SUMO22  ENSG000002285322  SUMO12  SUMO32  
    4 SIMAP similar genes for SUMO4 using alignment to 1 protein entry:     SUMO4_HUMAN:
    SUMO2    SUMO3    NFATC2IP    SUMO1

    SUMO4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    SUMO4_HUMAN, Q6EEV6: Variant Val-55 could be associated with insulin-dependent diabetes mellitus 5 (IDDM5) [MIM:600320]


    Selected SNPs for SUMO4 (see all 85)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2370251,2,,4
    C,F,A,Hother1149721310(-) CTTCAT/CTGACA 2 /M /V mis1 ese331Minor allele frequency- C:0.41MN NS EA NA WA CSA EU 8831
    rs1382780291,2
    --149719238(+) TAACCA/CAAAGA 1 -- us2k10--------
    rs2370271,2
    C,F,A,H--149719523(-) TAAACG/AATCAA 1 -- us2k195Minor allele frequency- A:0.10NS EA NA PA EU CA WA 5016
    rs7635901,2
    C,F,A,H--149719587(+) CAGGGA/TTCTAC 1 -- us2k114Minor allele frequency- T:0.16NA EA NS WA CSA 1038
    rs1824948241,2
    --149719690(+) ATAATA/GTATTT 1 -- us2k10--------
    rs358008351,2
    C,F--149719720(+) TACATA/GTAATT 1 -- us2k13Minor allele frequency- G:0.01NS NA 214
    rs345909711,2
    C,F--149719734(+) GGTTAG/CAGGGG 1 -- us2k15Minor allele frequency- C:0.04NS WA CSA 216
    rs347277711,2
    C,F--149719754(+) TGAAAA/GGCATT 1 -- us2k13Minor allele frequency- G:0.02NS NA 214
    rs1871857931,2
    --149719765(+) TCTTAC/TAGCGT 1 -- us2k10--------
    rs360710261,2
    C,F--149719768(+) TATAGC/AGTGTT 1 -- us2k12Minor allele frequency- A:0.01NS 94

    HapMap Linkage Disequilibrium report for SUMO4 (149721495 - 149722182 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SUMO4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522875CNV Loss19592680

    Human Gene Mutation Database (HGMD): SUMO4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUMO4
    DNA2.0 Custom Variant and Variant Library Synthesis for SUMO4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608829   
    OMIM disorders: 600320  
    17 diseases for SUMO4:    
    About MalaCards
    diabetes mellitus, insulin-dependent, 5    autoimmune thyroiditis    behcet's disease    diabetes mellitus
    graves' disease    diabetic retinopathy    diabetic nephropathy    rheumatoid arthritis
    coronary heart disease    type 1 diabetes    psoriasis    systemic lupus erythematosus
    coronary artery disease    thyroiditis    arthritis    lupus erythematosus
    insulin resistance

    1 disease from the University of Copenhagen DISEASES database for SUMO4:
    Diabetes mellitus

    SUMO4 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for SUMO4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune thyroid disease 62.7 1 16735488 (1)
    diabetes autoimmune 53.2 1 16735488 (1)
    autoimmunity 50.7 1 17374705 (1)
    diabetes mellitus insulin-dependent 46.9 4 15730420 (1), 15123604 (1), 17130563 (1)
    autoimmune diseases 46.3 5 16735488 (2), 17459725 (1), 19956095 (1), 16821265 (1)
    genetic susceptibility 40.5 1 16735488 (1)
    rheumatoid arthritis 21.2 4 16821265 (2), 16735488 (1), 16159953 (1)

    Genetic Association Database (GAD): SUMO4
    Human Genome Epidemiology (HuGE) Navigator: SUMO4 (30 documents)

    Export disorders for SUMO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUMO4 gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with SUMO4)
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    1. A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. (PubMed id 15123604)1, 2, 3, 4, 9 Bohren K.M.... Owerbach D. (J. Biol. Chem. 2004)
    2. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. (PubMed id 15247916)1, 2, 4, 9 Guo D.... Wang C.-Y. (Nat. Genet. 2004)
    3. Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. (PubMed id 15678135)1, 2, 4 Qu H.... Polychronakos C. (Nat. Genet. 2005)
    4. A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes. (PubMed id 17926234)1, 4, 9 Rudofsky G....Hamann A. (amp 2008)
    5. Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations. (PubMed id 17130530)1, 4, 9 Noso S....Ogihara T. (Ann. N. Y. Acad. Sci. 2006)
    6. The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis. (PubMed id 16159953)1, 4, 9 Gibbons L.J....Hinks A. (Rheumatology (Oxford) 2005)
    7. Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population. (PubMed id 17374705)1, 4, 9 Noso S....Ikegami H. (J. Clin. Endocrinol. Metab. 2007)
    8. SLC22A4, RUNX1, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: a case-control study in a Spanish population. (PubMed id 16821265)1, 4, 9 Orozco G....MartA-n J. (J. Rheumatol. 2006)
    9. No association of the codon 55 methionine to valine polymorphism in the SUMO4 gene with Graves' disease. (PubMed id 15730420)1, 4, 9 Jennings C.E....Pearce S.H. (Clin. Endocrinol. (Oxf) 2005)
    10. SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes. (PubMed id 17229939)1, 4, 9 Lin H.Y....Shin S.J. (Diabetes 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 387082 HGNC: 21181 Ensembl:ENSG00000177688 euGenes: HUgn387082 ECgene: SUMO4 Kegg: 387082
    H-InvDB: SUMO4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SUMO4 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/SUMO_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SUMO4 gene:
    Search GeneIP for patents involving SUMO4

    GeneCards and IP:
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