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SUMO3 Gene

protein-coding   GIFtS: 65
GCID: GC21M046735

Small Ubiquitin-Like Modifier 3

(Previous names: SMT3 (suppressor of mif two 3, yeast) homolog 1, SMT3 suppressor...)
(Previous symbol: SMT3H1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Small Ubiquitin-Like Modifier 31 2     SMT3A2
SMT3H11 2 3 5     Small Ubiquitin-Related Modifier 32
Ubiquitin-Like Protein SMT3B2 3     SMT3 Suppressor Of Mif Two 3 Homolog 12
SUMO-32 3     SMT3 Suppressor Of Mif Two 3 Homolog 32
Smt3B2 3     SMT3B3
SMT3 (Suppressor Of Mif Two 3, Yeast) Homolog 11     SUMO-23
SMT3 Suppressor Of Mif Two 3 Homolog 3 (S. Cerevisiae)1     SMT3 Homolog 13
SMT3 Suppressor Of Mif Two 3 Homolog 3 (Yeast)1     

External Ids:    HGNC: 111241   Entrez Gene: 66122   Ensembl: ENSG000001849007   OMIM: 6022315   UniProtKB: P558543   

Export aliases for SUMO3 gene to outside databases

Previous GC identifers: GC21M045083 GC21M045049 GC21M046191 GC21M031598 GC21M046548


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SUMO3 Gene:
This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The
encoded protein is covalently conjugated to other proteins via a post-translation modification known as
sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport,
DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced
transcript variants encoding distinct proteins have been described. (provided by RefSeq, Feb 2014)

GeneCards Summary for SUMO3 Gene:
SUMO3 (small ubiquitin-like modifier 3) is a protein-coding gene. GO annotations related to this gene include SUMO ligase activity. An important paralog of this gene is SUMO2.

UniProtKB/Swiss-Prot: SUMO3_HUMAN, P55854
Function: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a
lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of
ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport,
DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior
activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase
such as PIAS1-4, RANBP2 or CBX4

Gene Wiki entry for SUMO3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUMO3 gene promoter:
         p53   AML1a   AP-1   ATF-2   MEF-2A   c-Jun   aMEF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUMO3 promoter sequence
   Search Chromatin IP Primers for SUMO3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUMO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

SUMO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUMO3 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M046735:  view genomic region     (about GC identifiers)

Start:
46,225,532 bp from pter      End:
46,238,694 bp from pter
Size:
13,163 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SUMO3_HUMAN, P55854 (See protein sequence)
Recommended Name: Small ubiquitin-related modifier 3 precursor  
Size: 103 amino acids; 11637 Da
Subunit: Covalently attached to a number of proteins (By similarity). Interacts with USP25 (via ts SIM domain);
the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I
Caution: Frequently wrongly assigned as SMT3A in many databases and publications. However, according to initial
nomenclature, SUMO3 corresponds to SMT3B (PubMed:10692421)
2 PDB 3D structures from and Proteopedia for SUMO3:
1U4A (3D)        2IO1 (3D)    
Secondary accessions: B2R5X4 Q53HI9 Q6FGD4 Q9BWR4

Explore the universe of human proteins at neXtProt for SUMO3: NX_P55854

Explore proteomics data for SUMO3 at MOPED

Post-translational modifications: 

  • Polymeric chains can be formed through Lys-11 cross-linking1
  • Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function1
  • Ubiquitination2 at Lys5, Lys7, Lys20, Lys32, Lys34, Lys41, Lys44
  • Modification sites at PhosphoSitePlus

  • See SUMO3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273345.1  NP_008867.2  

    ENSEMBL proteins: 
     ENSP00000380995   ENSP00000330343   ENSP00000380990   ENSP00000409666  
    Reactome Protein details: P55854

    SUMO3 Human Recombinant Protein Products:

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    Enzo Life Sciences proteins for SUMO3
    OriGene Purified Proteins for SUMO3
    OriGene Protein Over-expression Lysate for SUMO3
    OriGene MassSpec for SUMO3
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    Novus Biologicals SUMO3 Proteins
    Novus Biologicals SUMO3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SUMO3
    Cloud-Clone Corp. Proteins for SUMO3

     
    Search eBioscience for Proteins for SUMO3 

     
    antibodies-online proteins for SUMO3 (36 products) 

     
    antibodies-online peptides for SUMO3

    SUMO3 Antibody Products:

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    antibodies-online antibodies for SUMO3 (91 products) 

    SUMO3 Assay Products:

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    Cloud-Clone Corp. CLIAs for SUMO3
    Search eBioscience for ELISAs for SUMO3 
    antibodies-online kits for SUMO3 (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR022617 Rad60/SUMO_like
     IPR027218 SUMO_chordates
     IPR000626 Ubiquitin_dom

    Graphical View of Domain Structure for InterPro Entry P55854

    ProtoNet protein and cluster: P55854

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: SUMO3_HUMAN, P55854
    Similarity: Belongs to the ubiquitin family. SUMO subfamily
    Similarity: Contains 1 ubiquitin-like domain


    Find genes that share domains with SUMO3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUMO3_HUMAN, P55854
    Function: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a
    lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of
    ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport,
    DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior
    activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase
    such as PIAS1-4, RANBP2 or CBX4

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17000644
    GO:0019789SUMO ligase activity ----
         
    Find genes that share ontologies with SUMO3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SUMO3:
     Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sumo3):
     no phenotypic analysis 

    Find genes that share phenotypes with SUMO3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SUMO3

    miRNA
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    miRTarBase miRNAs that target SUMO3:
    hsa-mir-24-3p (MIRT030396)

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    hsa-miR-328 hsa-miR-199b-3p hsa-miR-125a-3p hsa-miR-199a-3p hsa-miR-15a hsa-miR-3129-5p hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidSUMO3 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for SUMO3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUMO3
    Addgene plasmids for SUMO3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SUMO3_HUMAN, P55854: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore TAS9119407
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0016604nuclear body ----

    Find genes that share ontologies with SUMO3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SUMO3 About    
    See pathways by source

    SuperPathContained pathways About
    1Processing and Activation of SUMO
    Processing and Activation of SUMO
    SUMOylation0.00
    Conjugation of SUMO to E1 (UBA2-SAE1)0.00
    Proteolytic Processing of SUMO0.00
    Transfer of SUMO from E1 to E2 (UBE2I, UBC9)0.00
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3RNA transport
    RNA transport
    4Protein Stability
    Protein Stability
    5Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    Find genes that share SuperPaths with SUMO3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SUMO3
        JAK-STAT Pathway
    SUMO Pathway

    1 Cell Signaling Technology (CST) Pathway for SUMO3
        Protein Stability

    1 BioSystems Pathway for SUMO3
        Diurnally regulated genes with circadian orthologs


    3 Reactome Pathways for SUMO3
        SUMO is transferred from E1 to E2 (UBE2I, UBC9)
    SUMO is conjugated to E1 (UBA2:SAE1)
    SUMO is proteolytically processed


    1 Kegg Pathway  (Kegg details for SUMO3):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SUMO3
    Interactions:

        Search GeneGlobe Interaction Network for SUMO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUMO3 (P558541, 2, 3 ENSP000003303434) via UniProtKB, MINT, STRING, and/or I2D (see all 328)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USPL1Q5W0Q71, 2EBI-474067,EBI-2513899 MINT-8406214 MINT-8406704 MINT-8406783 MINT-8406250 MINT-8403906 MINT-8406769 MINT-8406198 MINT-8404150 MINT-8406021 MINT-8406733 MINT-8406233 MINT-8404174 MINT-8406294
    CUL3Q136182, 3, ENSP000002644144MINT-6542674 I2D: score=2 STRING: ENSP00000264414
    SMN1Q166372, 3MINT-8271564 I2D: score=2 
    SMN2Q166372, 3MINT-8271564 I2D: score=2 
    HIF1AQ166652, 3, ENSP000003380184MINT-7941500 I2D: score=1 STRING: ENSP00000338018
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016925protein sumoylation TAS--
    GO:0034504protein localization to nucleus ----
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--
    GO:2000060positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process ----

    Find genes that share ontologies with SUMO3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUMO3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SUMO3 gene (2 alternative transcripts): 
    NM_001286416.1  NM_006936.2  

    Unigene Cluster for SUMO3:

    SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
    Hs.474005  [show with all ESTs]
    Unigene Representative Sequence: NM_006936
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397898 ENST00000332859(uc002zfz.1 uc011afi.1) ENST00000479153
    ENST00000397893 ENST00000466861 ENST00000411651
    miRNA
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    hsa-miR-328 hsa-miR-199b-3p hsa-miR-125a-3p hsa-miR-199a-3p hsa-miR-15a hsa-miR-3129-5p hsa-miR-3916 hsa-miR-3125
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      QuantiTect SYBR Green Assays in human, mouse, rat SUMO3
      QuantiFast Probe-based Assays in human, mouse, rat SUMO3

    Additional mRNA sequence: 

    AK222591.1 AK300822.1 AK312350.1 BC000036.2 BC008420.1 BT007008.1 CR542173.1 CR542188.1 
    X99584.1 

    19 DOTS entries:

    DT.75108414  DT.453336  DT.97855480  DT.100846321  DT.95266529  DT.95266510  DT.95266528  DT.100680969 
    DT.100846306  DT.100846308  DT.100846312  DT.100846313  DT.121136741  DT.121136760  DT.91958452  DT.92456619 
    DT.92456622  DT.95266508  DT.121136725 

    Selected AceView cDNA sequences (see all 677):

    CR542188 AA371341 CR619289 CA307747 AI754040 AW079535 BQ068127 BU625517 
    BM752369 BM765141 BF593669 AI357977 CB110547 AI539691 W94169 BM799646 
    Z38925 AA428999 CD358520 AA305177 BU630068 R42238 BQ650864 AA378901 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SUMO3 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ·
    SP1:        -     -     -     -     -     -     -                       -     -     -                 -     -     -     -                                       
    SP2:                                                                    -     -     -                 -     -     -     -                                       
    SP3:                                                                    -     -     -                 -     -     -                                             
    SP4:                                                              -     -     -     -     -           -     -     -     -                                       
    SP5:                                                                    -     -     -                       -     -     -                                       

    ExUns: 10f · 10g
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for SUMO3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SUMO3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTCTCGT
    SUMO3 Expression
    About this image

    SUMO3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUMO3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474005

    UniProtKB/Swiss-Prot: SUMO3_HUMAN, P55854
    Tissue specificity: Expressed predominantly in liver

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUMO3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sumo31 , 5 SMT3 suppressor of mif two 3 homolog 3 (yeast)1, 5 90.94(n)1
    100(a)1
      10 (39.72 cM)5
    206101  NM_019929.31  NP_064313.11 
     776060975 
    chicken
    (Gallus gallus)
    Aves SUMO31 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) 90.32(n)
    97.85(a)
      770553  NM_001079498.1  NP_001072966.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    98(a)
    many ↔ many
    3(33862880-33876380)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC642972 hypothetical protein MGC64297 82.5(n)    BC043947.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa94a112 Danio rerio cDNA clone MGC65847 IMAGE6797324, complete more 89.18(n)    BC058303.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta smt31 smt3 75.56(n)
    74.44(a)
      33981  NM_058063.4  NP_477411.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMT36
    Ubiquitin-like protein of the SUMO family, conjuga...
    43(a)
    1 → many
    IV(1469400-1469705) YDR510W
    rice
    (Oryza sativa)
    Liliopsida Os.247292 Transcribed sequence with weak similarity to protein more 70.81(n)    CA762495.1 


    ENSEMBL Gene Tree for SUMO3 (if available)
    TreeFam Gene Tree for SUMO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUMO3 gene
    SUMO22  ENSG000002285322  SUMO42  SUMO12  
    6 SIMAP similar genes for SUMO3 using alignment to 4 protein entries:     SUMO3_HUMAN (see all proteins):
    SUMO2    SUMO4    OK/SW-cl.41    X-linked retinopathy protein    NFATC2IP    SUMO1

    Find genes that share paralogs with SUMO3           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for SUMO3 (see all 8)
    PGOHUM00000248128 PGOHUM00000248228 PGOHUM00000248812 PGOHUM00000248815 PGOHUM00000245294


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SUMO3 (see all 368)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs764558051,2
    C,F--46225067(+) CACCAC/TTGCAC 1 -- ds50013Minor allele frequency- T:0.04WA NA EA 358
    rs791199951,2
    C,F--46225312(+) GGTCTC/GTGAGG 1 -- ds50011Minor allele frequency- G:0.08NA 120
    rs28386921,2
    C,F,O,H--46225396(+) CCAGGC/TGAATA 1 -- ds50016Minor allele frequency- T:0.16NA NS WA 488
    rs785953731,2
    C,F--46225415(+) CCAGCG/AGCTAG 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1875162081,2
    --46225640(+) GCCCAA/TACAGC 1 -- ut310--------
    rs1923714571,2
    --46225644(+) ATACAG/TCAAAC 1 -- ut310--------
    rs1849655001,2
    --46225645(+) TACAGC/TAAACA 1 -- ut310--------
    rs2352921,2
    C,F,A,H--46225665(+) AACATT/GTCAGC 1 -- ut3121Minor allele frequency- G:0.09MN NS EA NA CSA WA 2448
    rs1469628471,2
    --46225685(+) AGCAAG/TCAAGA 1 -- ut310--------
    rs1380788751,2
    C--46225959(+) TACACA/GACAAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SUMO3 (46225532 - 46238694 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SUMO3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3540CNV Insertion18451855
    nsv459298CNV Loss19166990
    nsv913963CNV Loss21882294
    dgv4777n71CNV Loss21882294
    dgv4775n71CNV Loss21882294
    nsv913966CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUMO3
    DNA2.0 Custom Variant and Variant Library Synthesis for SUMO3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602231    OMIM disorders: --


    Find genes that share disorders with SUMO3           About GenesLikeMe

    Genetic Association Database (GAD): SUMO3
    Human Genome Epidemiology (HuGE) Navigator: SUMO3 (2 documents)

    Export disorders for SUMO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUMO3 gene, integrated from 10 sources (see all 153):
    (articles sorted by number of sources associating them with SUMO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. (PubMed id 9119407)1, 2, 3, 9 Lapenta V....Brahe C. (Genomics 1997)
    2. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PubMed id 12383504)1, 2, 9 Su H.-L. and Li S.S.-L. (Gene 2002)
    3. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PubMed id 15296745)1, 2, 9 Reverter D. and Lima C.D. (Structure 2004)
    4. Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. (PubMed id 18538659)1, 2 Meulmeester E.... Melchior F. (Mol. Cell 2008)
    5. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. (PubMed id 16608850)1, 2 Gong L. and Yeh E.T.H. (J. Biol. Chem. 2006)
    6. The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. (PubMed id 16553580)1, 2 Shen L.N.... Hay R.T. (Biochem. J. 2006)
    7. Solution structure of human SUMO-3 C47S and its binding surface for Ubc9. (PubMed id 15723523)1, 2 Ding H.... Shi Y. (Biochemistry 2005)
    8. Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1. (PubMed id 15487983)1, 2 Xu Z. and Au S.W.N. (Biochem. J. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. (PubMed id 12924945)1, 2 Tatham M.H.... Chen Y. (Biochemistry 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6612 HGNC: 11124 AceView: SUMO3 Ensembl:ENSG00000184900 euGenes: HUgn6612
    ECgene: SUMO3 Kegg: 6612 H-InvDB: SUMO3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SUMO3 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/SUMO_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SUMO3 gene:
    Search GeneIP for patents involving SUMO3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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