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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUMO3 Gene

protein-coding   GIFtS: 64
GCID: GC21M046548

Small Ubiquitin-Like Modifier 3

(Previous names: SMT3 (suppressor of mif two 3, yeast) homolog 1, SMT3 suppressor...)
(Previous symbol: SMT3H1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Small Ubiquitin-Like Modifier 31 2     SMT3 Suppressor Of Mif Two 3 Homolog 3 (S. Cerevisiae)1
SMT3H11 2 3 5     SMT3 Suppressor Of Mif Two 3 Homolog 3 (Yeast)1
Ubiquitin-Like Protein SMT3B2 3     SMT3A2
SUMO-22 3     Small Ubiquitin-Related Modifier 32
SUMO-32 3     SMT3 Suppressor Of Mif Two 3 Homolog 12
Smt3B2 3     SMT3 Suppressor Of Mif Two 3 Homolog 32
SMT3 Homolog 12 3     Ubiquitin-Like Protein SMT3A2
SMT3 (Suppressor Of Mif Two 3, Yeast) Homolog 11     SMT3B3

External Ids:    HGNC: 111241   Entrez Gene: 66122   Ensembl: ENSG000001849007   OMIM: 6022315   UniProtKB: P558543   

Export aliases for SUMO3 gene to outside databases

Previous GC identifers: GC21M045083 GC21M045049 GC21M046191 GC21M031598


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUMO3 Gene:
SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins
and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation,
sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional
regulation, apoptosis, and protein stability (Su and Li, 2002 (PubMed 12383504)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SUMO3 Gene: 
SUMO3 (small ubiquitin-like modifier 3) is a protein-coding gene. Diseases associated with SUMO3 include nevoid basal cell carcinoma syndrome, and basal cell carcinoma, and among its related super-pathways are Proteolytic Processing of SUMO. GO annotations related to this gene include protein binding and SUMO ligase activity. An important paralog of this gene is SUMO2.

UniProtKB/Swiss-Prot: SUMO3_HUMAN, P55854
Function: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a
lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of
ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport,
DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior
activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase
such as PIAS1-4, RANBP2 or CBX4

Gene Wiki entry for SUMO3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011515.12  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUMO3 gene promoter:
         p53   AML1a   AP-1   ATF-2   MEF-2A   c-Jun   aMEF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUMO3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SUMO3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUMO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

SUMO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUMO3 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M046548:  view genomic region     (about GC identifiers)

Start:
46,225,532 bp from pter      End:
46,238,694 bp from pter
Size:
13,163 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SUMO3_HUMAN, P55854 (See protein sequence)
Recommended Name: Small ubiquitin-related modifier 3 precursor  
Size: 103 amino acids; 11637 Da
Subunit: Covalently attached to a number of proteins (By similarity). Interacts with USP25 (via ts SIM domain);
the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I
Subcellular location: Cytoplasm
Caution: Frequently wrongly assigned as SMT3A in many databases and publications. However, according to initial
nomenclature, SUMO3 corresponds to SMT3B (PubMed:10692421)
2 PDB 3D structures from and Proteopedia for SUMO3:
1U4A (3D)        2IO1 (3D)    
Secondary accessions: B2R5X4 Q53HI9 Q6FGD4 Q9BWR4

Explore the universe of human proteins at neXtProt for SUMO3: NX_P55854

Explore proteomics data for SUMO3 at MOPED 

Post-translational modifications:

  • UniProtKB: Polymeric chains can be formed through Lys-11 cross-linking
  • UniProtKB: Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55854

  • SUMO3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SUMO3 Protein Expression
    REFSEQ proteins: NP_008867.2  
    ENSEMBL proteins: 
     ENSP00000380995   ENSP00000330343   ENSP00000380990   ENSP00000409666  
    Reactome Protein details: P55854
    Human Recombinant Protein Products for SUMO3: 
    EMD Millipore Purified and/or Recombinant SUMO3 Protein
    R&D Systems Recombinant & Natural Proteins for SUMO3 (Poly-SUMO3, Di-SUMO3, SUMO3)
    Enzo Life Sciences proteins for SUMO3
    OriGene Purified Protein for SUMO3
    OriGene Protein Over-expression Lysate for SUMO3
    OriGene MassSpec for SUMO3 
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    Novus Biologicals SUMO3 Proteins
    Novus Biologicals SUMO3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SUMO3
    Cloud-Clone Corp. Proteins for SUMO3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore TAS9119407
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0016604nuclear body IEA--

    SUMO3 for ontologies           About GeneDecksing



    SUMO3 Antibody Products: 
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    ThermoFisher Antibody for SUMO3
    LSBio Antibodies in human, mouse, rat for SUMO3 

    Assay Products for SUMO3: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SUMO3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SUMO3 
    Cloud-Clone Corp. CLIAs for SUMO3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR022617 SUMO
     IPR027218 SUMO_chordates
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry P55854

    ProtoNet protein and cluster: P55854

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: SUMO3_HUMAN, P55854
    Similarity: Belongs to the ubiquitin family. SUMO subfamily
    Similarity: Contains 1 ubiquitin-like domain


    SUMO3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUMO3_HUMAN, P55854
    Function: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a
    lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of
    ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport,
    DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior
    activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase
    such as PIAS1-4, RANBP2 or CBX4

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17000644
    GO:0019789SUMO ligase activity IEA--
         
    SUMO3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SUMO3:
     Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sumo3):
     no phenotypic analysis 

    SUMO3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SUMO3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUMO3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUMO3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUMO3 

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    hsa-miR-328 hsa-miR-199b-3p hsa-miR-125a-3p hsa-miR-199a-3p hsa-miR-15a hsa-miR-3129-5p hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidSUMO3 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SUMO3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SUMOylation
    SUMOylation0.67
    Processing and Activation of SUMO0.67
    Proteolytic Processing of SUMO0.67
    Conjugation of SUMO to E1 (UBA2:SAE1)0.56
    2RNA transport
    RNA transport
    3Protein Stability
    Protein Stability
    4Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SUMO3
        Protein Stability

    1 BioSystems Pathway for SUMO3
        Diurnally regulated genes with circadian orthologs

    4        Reactome Pathways for SUMO3
        Conjugation of SUMO to E1 (UBA2:SAE1)
    SUMOylation
    Processing and Activation of SUMO
    Proteolytic Processing of SUMO


    1         Kegg Pathway  (Kegg details for SUMO3):
        RNA transport


    SUMO3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SUMO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/238 Interacting proteins for SUMO3 (P558541, 2, 3 ENSP000003303434) via UniProtKB, MINT, STRING, and/or I2D (see all 238)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USPL1Q5W0Q72MINT-8406214 MINT-8406704 MINT-8406783 MINT-8406250 MINT-8403906 MINT-8406769 MINT-8406198 MINT-8404150 MINT-8406021 MINT-8406733 MINT-8406233 MINT-8404174 MINT-8406294
    CUL3Q136182, 3, ENSP000002644144MINT-6542674 I2D: score=2 STRING: ENSP00000264414
    SMN1Q166372, 3MINT-8271564 I2D: score=2 
    SMN2Q166372, 3MINT-8271564 I2D: score=2 
    HIF1AQ166652, 3, ENSP000003380184MINT-7941500 I2D: score=1 STRING: ENSP00000338018
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016925protein sumoylation TAS--
    GO:0034504protein localization to nucleus IEA--
    GO:2000060positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IEA--

    SUMO3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUMO3

    Search CenterWatch for drugs/clinical trials and news about SUMO3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUMO3 gene: 
    NM_006936.2  

    Unigene Cluster for SUMO3:

    SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
    Hs.474005  [show with all ESTs]
    Unigene Representative Sequence: NM_006936
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397898 ENST00000332859(uc002zfz.1 uc011afi.1) ENST00000479153
    ENST00000397893 ENST00000466861 ENST00000411651
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate SUMO3 (see all 22):
    hsa-miR-328 hsa-miR-199b-3p hsa-miR-125a-3p hsa-miR-199a-3p hsa-miR-15a hsa-miR-3129-5p hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidSUMO3 3' UTR sequence
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUMO3

    Additional mRNA sequence: 

    AK222591.1 AK300822.1 AK312350.1 BC000036.2 BC008420.1 BT007008.1 CR542173.1 CR542188.1 
    X99584.1 

    19 DOTS entries:

    DT.75108414  DT.453336  DT.97855480  DT.100846321  DT.95266529  DT.95266510  DT.95266528  DT.100680969 
    DT.100846306  DT.100846308  DT.100846312  DT.100846313  DT.121136741  DT.121136760  DT.91958452  DT.92456619 
    DT.92456622  DT.95266508  DT.121136725 

    24/677 AceView cDNA sequences (see all 677):

    BM763714 BM981833 AA888980 BQ638896 AI245230 AU135870 AA166637 BQ232847 
    CR601502 BM974905 AI633480 AA635993 BM748842 BE378613 BM799646 AW079535 
    AI791397 BU538490 CR590791 AI364296 BE677179 BM683252 CR590916 BG765614 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for SUMO3 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ·
    SP1:        -     -     -     -     -     -     -                       -     -     -                 -     -     -     -                                       
    SP2:                                                                    -     -     -                 -     -     -     -                                       
    SP3:                                                                    -     -     -                 -     -     -                                             
    SP4:                                                              -     -     -     -     -           -     -     -     -                                       
    SP5:                                                                    -     -     -                       -     -     -                                       

    ExUns: 10f · 10g
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for SUMO3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUMO3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTCTCGT
    SUMO3 Expression
    About this image


    See SUMO3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUMO3

    SOURCE GeneReport for Unigene cluster: Hs.474005

    UniProtKB/Swiss-Prot: SUMO3_HUMAN, P55854
    Tissue specificity: Expressed predominantly in liver

        SABiosciences Custom PCR Arrays for SUMO3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUMO3 gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sumo31 , 5 SMT3 suppressor of mif two 3 homolog 3 (yeast)1, 5 90.94(n)1
    100(a)1
      10 (39.72 cM)5
    206101  NM_019929.31  NP_064313.11 
     776060975 
    chicken
    (Gallus gallus)
    Aves SUMO31 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) 90.32(n)
    97.85(a)
      770553  NM_001079498.1  NP_001072966.1 
    lizard
    (Anolis carolinensis)
    Reptilia SUMO36
    Uncharacterized protein
    98(a)
    1 ↔ 1
    3(33862880-33876380)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC642972 hypothetical protein MGC64297 82.5(n)    BC043947.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa94a112 Danio rerio cDNA clone MGC65847 IMAGE6797324, complete more 89.18(n)    BC058303.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta smt31 CG4494-PA 75.56(n)
    74.44(a)
      33981  NM_058063.3  NP_477411.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMT36
    Ubiquitin-like protein of the SUMO family, conjuga...
    43(a)
    1 → many
    IV(1469400-1469705)
    rice
    (Oryza sativa)
    Liliopsida Os.247292 Transcribed sequence with weak similarity to protein more 70.81(n)    CA762495.1 


    ENSEMBL Gene Tree for SUMO3 (if available)
    TreeFam Gene Tree for SUMO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUMO3 gene
    SUMO22  ENSG000002285322  SUMO42  SUMO12  
    6 SIMAP similar genes for SUMO3 using alignment to 4 protein entries:     SUMO3_HUMAN (see all proteins):
    SUMO2    SUMO4    OK/SW-cl.41    X-linked retinopathy protein    NFATC2IP    SUMO1

    SUMO3 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for SUMO3 (see all 8)
    PGOHUM00000248128 PGOHUM00000248228 PGOHUM00000248812 PGOHUM00000248815 PGOHUM00000245294


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/368 SNPs in SUMO3 are shown (see all 368)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs764558051,2
    C,F--46225067(+) CACCAC/TTGCAC 1 -- ds50013Minor allele frequency- T:0.04WA NA EA 358
    rs791199951,2
    C,F--46225312(+) GGTCTC/GTGAGG 1 -- ds50011Minor allele frequency- G:0.08NA 120
    rs28386921,2
    C,F,O,H--46225396(+) CCAGGC/TGAATA 1 -- ds50016Minor allele frequency- T:0.16NA NS WA 488
    rs785953731,2
    C,F--46225415(+) CCAGCG/AGCTAG 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1875162081,2
    --46225640(+) GCCCAA/TACAGC 1 -- ut310--------
    rs1923714571,2
    --46225644(+) ATACAG/TCAAAC 1 -- ut310--------
    rs1849655001,2
    --46225645(+) TACAGC/TAAACA 1 -- ut310--------
    rs2352921,2
    C,F,A,H--46225665(+) AACATT/GTCAGC 1 -- ut3121Minor allele frequency- G:0.09MN NS EA NA CSA WA 2448
    rs1469628471,2
    --46225685(+) AGCAAG/TCAAGA 1 -- ut310--------
    rs1380788751,2
    C--46225959(+) TACACA/GACAAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SUMO3 (46225532 - 46238694 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SUMO3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3540CNV Insertion18451855
    nsv459298CNV Loss19166990
    nsv913963CNV Loss21882294
    dgv4777n71CNV Loss21882294
    dgv4775n71CNV Loss21882294
    nsv913966CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602231    OMIM disorders: --

    13 diseases for SUMO3:    About MalaCards
    nevoid basal cell carcinoma syndrome    basal cell carcinoma    transient cerebral ischemia    myocarditis
    herpes simplex    ischemia    cerebritis    liver disease
    pancreatic cancer    pancreatitis    thyroiditis    leukemia
    hepatitis


    SUMO3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SUMO3
    Human Genome Epidemiology (HuGE) Navigator: SUMO3 (2 documents)

    Export disorders for SUMO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUMO3 gene, integrated from 9 sources (see all 146):
    (articles sorted by number of sources associating them with SUMO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. (PubMed id 9119407)1, 2, 3, 9 Lapenta V....Brahe C. (1997)
    2. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PubMed id 12383504)1, 2, 9 Su H.-L. and Li S.S.-L. (2002)
    3. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PubMed id 15296745)1, 2, 9 Reverter D. and Lima C.D. (2004)
    4. Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. (PubMed id 18538659)1, 2 Meulmeester E....Melchior F. (2008)
    5. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. (PubMed id 16608850)1, 2 Gong L. and Yeh E.T.H. (2006)
    6. The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. (PubMed id 16553580)1, 2 Shen L.N.... Hay R.T. (2006)
    7. Solution structure of human SUMO-3 C47S and its binding surface for Ubc9. (PubMed id 15723523)1, 2 Ding H.... Shi Y. (2005)
    8. Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1. (PubMed id 15487983)1, 2 Xu Z. and Au S.W.N. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. (PubMed id 12924945)1, 2 Tatham M.H.... Chen Y. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6612 HGNC: 11124 AceView: SUMO3 Ensembl:ENSG00000184900 euGenes: HUgn6612
    ECgene: SUMO3 Kegg: 6612 H-InvDB: SUMO3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUMO3 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/SUMO_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUMO3 gene:
    Search GeneIP for patents involving SUMO3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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