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SUMO2 Gene

protein-coding   GIFtS: 62
GCID: GC17M073163

Small Ubiquitin-Like Modifier 2

(Previous names: SMT3 (suppressor of mif two 3, yeast) homolog 2, SMT3 suppressor...)
(Previous symbol: SMT3H2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Small Ubiquitin-Like Modifier 21 2     SUMO32
SMT3H21 2 3     Sentrin 22
Ubiquitin-Like Protein SMT3A2 3     Small Ubiquitin-Related Modifier 22
HSMT32 3     SMT3 Suppressor Of Mif Two 3 Homolog 22
Smt3A2 3     Ubiquitin-Like Protein SMT3B2
SMT3 Homolog 22 3     SMT3A3
SMT3 (Suppressor Of Mif Two 3, Yeast) Homolog 21     SUMO-23
SMT3 Suppressor Of Mif Two 3 Homolog 2 (S. Cerevisiae)1     SUMO-33
SMT3 Suppressor Of Mif Two 3 Homolog 2 (Yeast)1     Sentrin-23
SMT3B2     

External Ids:    HGNC: 111251   Entrez Gene: 66132   Ensembl: ENSG000001886127   OMIM: 6030425   UniProtKB: P619563   

Export aliases for SUMO2 gene to outside databases

Previous GC identifers: GC17M073761 GC17M070675 GC17M068573


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SUMO2 Gene:
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It
functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational
modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved
in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein
stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off.
Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding
different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for SUMO2 Gene:
SUMO2 (small ubiquitin-like modifier 2) is a protein-coding gene. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is ENSG00000228532.

UniProtKB/Swiss-Prot: SUMO2_HUMAN, P61956
Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked
polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex
SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or
CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of
cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.
Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal
degradation of modified proteins

Gene Wiki entry for SUMO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUMO2 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUMO2 promoter sequence
   Search Chromatin IP Primers for SUMO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUMO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

SUMO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUMO2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M073163:  view genomic region     (about GC identifiers)

Start:
73,163,408 bp from pter      End:
73,179,098 bp from pter
Size:
15,691 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SUMO2_HUMAN, P61956 (See protein sequence)
Recommended Name: Small ubiquitin-related modifier 2 precursor  
Size: 95 amino acids; 10871 Da
Subunit: Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the
biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number
of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1,
CASP8AP2, RNF111 AND SOBP (via SIM domains)
Caution: Frequently wrongly assigned as SMT3B in many databases and publications. However, according to initial
nomenclature, SUMO2 corresponds to SMT3A (PubMed:10692421)
Selected PDB 3D structures from and Proteopedia for SUMO2 (see all 15):
1WM2 (3D)        1WM3 (3D)        1WZ0 (3D)        1Z5Q (3D)        2AWT (3D)        2CKH (3D)    
Secondary accessions: B2R4I2 P55855 Q32Q42 Q6IPZ6 Q96HK1
Alternative splicing: 2 isoforms:  P61956-1   P61956-2   

Explore the universe of human proteins at neXtProt for SUMO2: NX_P61956

Explore proteomics data for SUMO2 at MOPED

Post-translational modifications: 

  • Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-,
    'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF41
  • Cleavage of precursor form by SENP1 or SENP2 is necessary for function1
  • Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitylation by the UBE2V1-UBE2N
    heterodimer1
  • Ubiquitination2 at Lys5, Lys7, Lys21, Lys33, Lys35, Lys42, Lys45
  • Modification sites at PhosphoSitePlus

  • See SUMO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005849.1  NP_008868.3  

    ENSEMBL proteins: 
     ENSP00000405965   ENSP00000400886   ENSP00000461997  
    Reactome Protein details: P61956

    SUMO2 Human Recombinant Protein Products:

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    Novus Biologicals SUMO2 Proteins
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    antibodies-online proteins for SUMO2 (36 products) 

     
    antibodies-online peptides for SUMO2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR022617 Rad60/SUMO_like
     IPR027218 SUMO_chordates
     IPR000626 Ubiquitin_dom

    Graphical View of Domain Structure for InterPro Entry P61956

    ProtoNet protein and cluster: P61956

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: SUMO2_HUMAN, P61956
    Similarity: Belongs to the ubiquitin family. SUMO subfamily
    Similarity: Contains 1 ubiquitin-like domain


    Find genes that share domains with SUMO2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUMO2_HUMAN, P61956
    Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked
    polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex
    SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or
    CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of
    cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.
    Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal
    degradation of modified proteins

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15383276
    GO:0031625ubiquitin protein ligase binding IPI18408734
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SUMO2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SUMO2:
     High actin ratio cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SUMO2

    miRNA
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    miRTarBase miRNAs that target SUMO2:
    hsa-let-7b-5p (MIRT051926), hsa-mir-186-5p (MIRT045212)

    Block miRNA regulation of human, mouse, rat SUMO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUMO2 (see all 21):
    hsa-miR-411* hsa-miR-379* hsa-miR-624 hsa-miR-340 hsa-miR-515-5p hsa-miR-1265 hsa-miR-3613-3p hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidSUMO2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SUMO2

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    GenScript: all cDNA clones in your preferred vector (see all 2): SUMO2 (NM_006937)
    Sino Biological Human cDNA Clone for SUMO2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUMO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUMO2
    Addgene plasmids for SUMO2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SUMO2_HUMAN, P61956: Nucleus. Nucleus, PML body
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0016605PML body IDA--

    Find genes that share ontologies with SUMO2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SUMO2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Processing and Activation of SUMO
    Processing and Activation of SUMO
    SUMOylation0.00
    Conjugation of SUMO to E1 (UBA2-SAE1)0.00
    Proteolytic Processing of SUMO0.00
    Transfer of SUMO from E1 to E2 (UBE2I, UBC9)0.00
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3Wnt signaling pathway (KEGG)
    Wnt Signaling Pathway NetPath0.37
    4RNA transport
    RNA transport
    5Protein Stability
    Protein Stability


    Find genes that share SuperPaths with SUMO2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SUMO2
        JAK-STAT Pathway
    SUMO Pathway

    1 Cell Signaling Technology (CST) Pathway for SUMO2
        Protein Stability

    2 BioSystems Pathways for SUMO2
        Wnt Signaling Pathway NetPath
    Glucocorticoid receptor regulatory network


    3 Reactome Pathways for SUMO2
        SUMO is transferred from E1 to E2 (UBE2I, UBC9)
    SUMO is conjugated to E1 (UBA2:SAE1)
    SUMO is proteolytically processed


    1 Kegg Pathway  (Kegg details for SUMO2):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SUMO2
    Interactions:

        GeneGlobe Interaction Network for SUMO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUMO2 (P619561, 2, 3 ENSP000004059654) via UniProtKB, MINT, STRING, and/or I2D (see all 1363)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000232804P081073, ENSP000003930874I2D: score=1 STRING: ENSP00000393087
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016925protein sumoylation TAS--
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA18408734
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with SUMO2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUMO2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SUMO2 gene (2 alternative transcripts): 
    NM_001005849.1  NM_006937.3  

    Unigene Clusters for SUMO2:

    SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
    Hs.380973  [show with all ESTs], Hs.546298  [show with all ESTs]
    Unigene Representative Sequences: BM475081, BC008450
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420826(uc002jne.3 uc002jnf.3) ENST00000314523 ENST00000578238

    miRNA
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    hsa-miR-411* hsa-miR-379* hsa-miR-624 hsa-miR-340 hsa-miR-515-5p hsa-miR-1265 hsa-miR-3613-3p hsa-miR-1243
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    Additional mRNA sequence: 

    AK024823.1 AK225090.1 BC008450.1 BC016775.1 BC022340.1 BC062713.1 BC068465.1 BC070159.1 
    BC071645.1 BC071646.1 BC107853.1 X99585.1 

    Selected DOTS entries (see all 39):

    DT.448801  DT.91952483  DT.95344890  DT.92056459  DT.91775567  DT.95275187  DT.92373823  DT.100886022 
    DT.91871643  DT.121291596  DT.121390529  DT.102838661  DT.91775554  DT.100767787  DT.91917384  DT.120997915 
    DT.95275223  DT.100041704  DT.100043737  DT.100886010  DT.100886013  DT.121291601  DT.95275009  DT.100886021 

    Selected AceView cDNA sequences (see all 1667):

    BF149131 CB124111 BM916926 CA842411 AI342122 BU182036 BM687915 BI522462 
    BI752533 BQ071848 AI335340 T31562 AA902300 CR613024 BM756369 BX424588 
    AI086525 BQ646621 BE712790 AA731417 H89345 BF594429 CR601210 AW007563 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SUMO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGGCAATC
    SUMO2 Expression
    About this image

    SUMO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUMO2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.380973 Hs.546298

    UniProtKB/Swiss-Prot: SUMO2_HUMAN, P61956
    Tissue specificity: Broadly expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SUMO2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sumo21 , 5 SMT3 suppressor of mif two 3 homolog 2 (yeast)1, 5 95.79(n)1
    100(a)1
      11 (80.84 cM)5
    1709301  NM_133354.21  NP_579932.11 
     1155231025 
    chicken
    (Gallus gallus)
    Aves SUMO21 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 91.58(n)
    100(a)
      770125  NM_001080717.2  NP_001074186.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia smt3h2-prov2 SMT3 suppressor of mif two 3 homolog 2 (yeast) 80.08(n)    BC045271.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sumo2b1 SMT3 suppressor of mif two 3 homolog 2b 81.72(n)
    98.92(a)
      445027  NM_001003422.2  NP_001003422.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta smt36
    smt3
    73(a)
    1 → many
    2L(6966780-6967644)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMT36
    Ubiquitin-like protein of the SUMO family, conjuga...
    43(a)
    1 → many
    IV(1469400-1469705) YDR510W


    ENSEMBL Gene Tree for SUMO2 (if available)
    TreeFam Gene Tree for SUMO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUMO2 gene
    ENSG000002285322  SUMO42  SUMO12  SUMO32  
    4 SIMAP similar genes for SUMO2 using alignment to 2 protein entries:     SUMO2_HUMAN (see all proteins):
    SUMO3    SUMO4    SUMO1    NFATC2IP

    Find genes that share paralogs with SUMO2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for SUMO2 (see all 27)
    PGOHUM00000247095 PGOHUM00000237102 PGOHUM00000237432 PGOHUM00000235051 PGOHUM00000263121


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SUMO2 (see all 365)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501391171,2
    C--73163541(+) CCCTAC/TGCTCC 2 -- ds50010--------
    rs1924522641,2
    --73163546(+) TGCTCC/TGTGCC 2 -- ds50010--------
    rs1385587451,2
    C--73163676(+) AAACTA/GTTATT 2 -- ds50010--------
    rs1825445991,2
    --73163738(+) CCTTCG/TTGAAA 2 -- ds50010--------
    rs620850301,2
    F--73163739(+) CTTCTT/GGAAAT 2 -- ds50012Minor allele frequency- G:0.02NA 122
    rs21270811,2
    C,H--73163777(+) TTTTTC/TTAAGC 2 -- ds50015Minor allele frequency- T:0.00NS EA NA 420
    rs1180661021,2
    C,F--73163808(+) TTCTCA/GGAATA 2 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1880562651,2
    --73163921(+) CCCTAA/CTTAAA 2 -- ut310--------
    rs2019244511,2
    --73164430(+) GTTCCC/GTTTTC 2 -- ut310--------
    rs1897306681,2
    --73164586(+) TGTACA/CTGTTC 2 -- int10--------

    HapMap Linkage Disequilibrium report for SUMO2 (73163408 - 73179098 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SUMO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908756CNV Loss21882294
    nsv908758CNV Loss21882294
    nsv2141CNV Loss18451855
    nsv908759CNV Loss21882294
    nsv470602CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUMO2
    DNA2.0 Custom Variant and Variant Library Synthesis for SUMO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603042    OMIM disorders: --


    Find genes that share disorders with SUMO2           About GenesLikeMe


    Export disorders for SUMO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUMO2 gene, integrated from 10 sources (see all 209):
    (articles sorted by number of sources associating them with SUMO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene. (PubMed id 8630065)1, 2, 3 Mannen H.... Li S.S.-L. (Biochem. Biophys. Res. Commun. 1996)
    2. Characterization of a second member of the sentrin family of ubiquitin-like proteins. (PubMed id 9556629)1, 2, 9 Kamitani T.... Yeh E.T.H. (J. Biol. Chem. 1998)
    3. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PubMed id 12383504)1, 2, 9 Su H.-L. and Li S.S.-L. (Gene 2002)
    4. Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins. (PubMed id 15479240)1, 2, 9 Huang W.-C.... Wang A.H.-J. (Eur. J. Biochem. 2004)
    5. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PubMed id 15296745)1, 2, 9 Reverter D. and Lima C.D. (Structure 2004)
    6. Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. (PubMed id 11451954)1, 2, 9 Tatham M.H.... Hay R.T. (J. Biol. Chem. 2001)
    7. Ube2W conjugates ubiquitin to I+-amino groups of protein N-termini. (PubMed id 23560854)1, 2 Tatham M.H....Hay R.T. (Biochem. J. 2013)
    8. PolySUMO-binding proteins identified through a string search. (PubMed id 23086935)1, 2 Sun H. and Hunter T. (J. Biol. Chem. 2012)
    9. Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. (PubMed id 18538659)1, 2 Meulmeester E.... Melchior F. (Mol. Cell 2008)
    10. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. (PubMed id 18408734)1, 2 Tatham M.H.... Hay R.T. (Nat. Cell Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6613 HGNC: 11125 AceView: SUMO2andHN1 Ensembl:ENSG00000188612 euGenes: HUgn6613
    ECgene: SUMO2 Kegg: 6613 H-InvDB: SUMO2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SUMO2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/SUMO_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SUMO2 gene:
    Search GeneIP for patents involving SUMO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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