Aliases for SUMO2 Gene
External Ids for SUMO2 Gene
Previous HGNC Symbols for SUMO2 Gene
Previous GeneCards Identifiers for SUMO2 Gene
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for SUMO2 Gene
SUMO2 (Small Ubiquitin-Like Modifier 2) is a Protein Coding gene. Diseases associated with SUMO2 include Setx. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Regulation of Glucokinase by Glucokinase Regulatory Protein. GO annotations related to this gene include poly(A) RNA binding and SUMO transferase activity. An important paralog of this gene is SUMO4.
UniProtKB/Swiss-Prot for SUMO2 Gene
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).