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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUMO2 Gene

protein-coding   GIFtS: 60
GCID: GC17M073163

SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)

(Previous names: SMT3 (suppressor of mif two 3, yeast) homolog 2, SMT3 suppressor...)
(Previous symbol: SMT3H2)
 Explore 13 diseases affiliated with
SUMO2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SUMO2    

Aliases
for SUMO2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SMT3 Suppressor Of Mif Two 3 Homolog 2 (S. Cerevisiae)1 2     SUMO32
SMT3H21 2 3     Sentrin 22
SMT3B1 2     Small Ubiquitin-Like Modifier 22
Ubiquitin-Like Protein SMT3A2 3     Small Ubiquitin-Related Modifier 22
HSMT32 3     Ubiquitin-Like Protein SMT3B2
Smt3A2 3     SMT3A3
SMT3 Homolog 22 3     SUMO-23
SMT3 (Suppressor Of Mif Two 3, Yeast) Homolog 21     SUMO-33
SMT3 Suppressor Of Mif Two 3 Homolog 2 (Yeast)1     Sentrin-23

External Ids:    HGNC: 111251   Entrez Gene: 66132   Ensembl: ENSG000001886127   OMIM: 6030425   UniProtKB: P619563   

Export aliases for SUMO2 gene to outside databases

Previous GC identifers: GC17M073761 GC17M070675 GC17M068573


Summaries
for SUMO2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SUMO2:
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions
in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification
system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of
cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not
active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been
reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been
characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SUMO2_HUMAN, P61956
Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked
polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex
SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular
processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2
chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified
proteins

Gene Wiki entry for SUMO2


Genomic Views
for SUMO2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUMO2 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SUMO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SUMO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUMO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

SUMO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUMO2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M073163:  view genomic region     (about GC identifiers)

Start:
 73,163,408 bp from pter      End:
 73,179,098 bp from pter
Size:
 15,691 bases      Orientation:
 minus strand

Proteins
for SUMO2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SUMO2_HUMAN, P61956 (See protein sequence)
Recommended Name: Small ubiquitin-related modifier 2 precursor  
Size: 95 amino acids; 10871 Da
Subunit: Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the
biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of
proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1,
CASP8AP2, RNF111 AND SOBP (via SIM domains)
Subcellular location: Nucleus. Note=Nuclear bodies
Caution: Frequently wrongly assigned as SMT3B in many databases and publications. However, according to initial
nomenclature, SUMO2 corresponds to SMT3A (PubMed:10692421)
6/13 PDB 3D structures from and Proteopedia for SUMO2 (see all 13):
1WM2 (3D)        1WM3 (3D)        1WZ0 (3D)        1Z5Q (3D)        2AWT (3D)        2CKH (3D)    
Secondary accessions: B2R4I2 P55855 Q32Q42 Q6IPZ6 Q96HK1
Alternative splicing: 2 isoforms:  P61956-1   P61956-2   

Explore the universe of human proteins at neXtProt for SUMO2: NX_P61956

Post-translational modifications:

  • Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-,
    • 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF41
  • Cleavage of precursor form by SENP1 or SENP2 is necessary for function1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61956

    • SUMO2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005849.1  NP_008868.3  

    ENSEMBL proteins: 
     ENSP00000405965   ENSP00000400886   ENSP00000461997  

    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for SUMO2 (Poly-SUMO2, Di-SUMO2, SUMO2)
    Enzo Life Sciences proteins for SUMO2
    OriGene Purified Proteins (see all 2): SUMO2
    OriGene Protein Over-expression Lysate (see all 2): SUMO2
    OriGene Custom Protein Services for SUMO2 
    GenScript Custom Purified and Recombinant Proteins Services for SUMO2
    Novus Biologicals SUMO2 Proteins
    Novus Biologicals SUMO2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SUMO2
    Uscn Proteins for SUMO2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    SUMO2 for ontologies           About GeneDecksing



    SUMO2 Antibody Products: 
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    R&D Systems Antibodies for SUMO2
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    Abcam antibodies for SUMO2 
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    ThermoFisher Antibodies for SUMO2

    Assay Products for SUMO2: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Ubiquitin Proteasome Pathway (UPP) Assay Kits & Reagents for SUMO2
    GenScript Custom Assay Services for SUMO2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SUMO2

    Protein Domains /
    Families
    for SUMO2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SUMO2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR022617 SUMO
     IPR027218 SUMO_chordates
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry P61956

    ProtoNet protein and cluster: P61956

    1 Blocks protein family: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: SUMO2_HUMAN, P61956
    Similarity: Belongs to the ubiquitin family. SUMO subfamily
    Similarity: Contains 1 ubiquitin-like domain


    Function
    for SUMO2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SUMO2_HUMAN, P61956
    Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked
    polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex
    SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.
    This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular
    processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2
    chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified
    proteins

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUMO2
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate SUMO2 (see all 21):
    hsa-miR-411* hsa-miR-379* hsa-miR-624 hsa-miR-340 hsa-miR-515-5p hsa-miR-1265 hsa-miR-3613-3p hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmid: SUMO2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUMO2 (see all 6)
    OriGene shRNA RFP: SUMO2
    OriGene siRNA: SUMO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUMO2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SUMO2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SUMO2 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SUMO2 (NM_006937)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUMO2 

    Cell Line
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    Search LifeMap BioReagents cell lines for SUMO2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0031625ubiquitin protein ligase binding IPI18408734


    SUMO2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SUMO2:
     High actin ratio cells 


    Pathways & Interactions
    for SUMO2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Protein Stability
    		Protein Stability1.00
    2Glucocorticoid receptor regulatory network
    		Glucocorticoid receptor regulatory network1.00
    3RNA transport
    		RNA transport1.00
    4Wnt Signaling Pathway
    		Wnt Signaling Pathway NetPath0.22

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SUMO2
        Protein Stability

    2 BioSystems Pathways for SUMO2 
        Wnt Signaling Pathway NetPath
    Glucocorticoid receptor regulatory network


    1         Kegg Pathway  (Kegg details for SUMO2):
        RNA transport


    SUMO2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SUMO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1228 Interacting proteins for SUMO2 (P619561, 2, 3 ENSP000004059654) via UniProtKB, MINT, STRING, and/or I2D (see all 1228)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2IP632792, 3, ENSP000003248974MINT-4958465 MINT-4958499 MINT-4958524 MINT-4958540 MINT-4958511 MINT-4958483 I2D: score=3 STRING: ENSP00000324897
    CHD3Q128732, 3, ENSP000003697164MINT-3979689 MINT-65174 MINT-8272344 I2D: score=4 STRING: ENSP00000369716
    TANKQ928442, 3, ENSP000002590754MINT-8144281 MINT-8144197 MINT-8144217 I2D: score=1 STRING: ENSP00000259075
    BADQ929342, 3, ENSP000003091034MINT-8249212 I2D: score=2 STRING: ENSP00000309103
    MYBP102421, 3, ENSP000003399924EBI-2512339,EBI-298355 I2D: score=1 STRING: ENSP00000339992
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016925protein sumoylation IDA17696781
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA18408734


    SUMO2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SUMO2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUMO2
    Search CenterWatch for drugs/clinical trials and news about SUMO2 

    Transcripts
    for SUMO2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SUMO2 gene (2 alternative transcripts): 
    NM_001005849.1  NM_006937.3  

    Unigene Clusters for SUMO2:

    SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
    Hs.380973  [show with all ESTs], Hs.546298  [show with all ESTs]
    Unigene Representative Sequences: BM475081, BC008450
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420826(uc002jne.3 uc002jnf.3) ENST00000314523 ENST00000578238


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUMO2
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate SUMO2 (see all 21):
    hsa-miR-411* hsa-miR-379* hsa-miR-624 hsa-miR-340 hsa-miR-515-5p hsa-miR-1265 hsa-miR-3613-3p hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmid: SUMO2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SUMO2 (see all 6)
    OriGene shRNA RFP: SUMO2
    OriGene siRNA: SUMO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SUMO2
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SUMO2 (NM_006937)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUMO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUMO2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SUMO2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SUMO2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUMO2

    Additional cDNA sequence: 

    AK024823.1 AK225090.1 BC008450.1 BC016775.1 BC022340.1 BC062713.1 BC068465.1 BC070159.1 
    BC071645.1 BC071646.1 BC107853.1 X99585.1 

    24/39 DOTS entries (see all 39):

    DT.448801  DT.91952483  DT.95344890  DT.92056459  DT.91775567  DT.95275187  DT.92373823  DT.100886022 
    DT.91871643  DT.121291596  DT.121390529  DT.102838661  DT.91775554  DT.100767787  DT.91917384  DT.120997915 
    DT.95275223  DT.100041704  DT.100043737  DT.100886010  DT.100886013  DT.121291601  DT.95275009  DT.100886021 

    24/1667 AceView cDNA sequences (see all 1667):

    AA721139 BM765147 T31562 BG105351 AA304897 AF086910 AI440228 CR594206 
    CB125605 BQ071893 CB992361 NM_001002032 AI349354 AI335340 AI086525 CD368239 
    BQ071663 BX424588 AI014694 CR605576 AW239052 CR590293 BQ064235 CR608252 

    GeneLoc Exon Structure


    Expression
    for SUMO2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUMO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGGGCAATC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SUMO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUMO2

    SOURCE GeneReport for Unigene clusters: Hs.380973 Hs.546298

    UniProtKB/Swiss-Prot: SUMO2_HUMAN, P61956
    Tissue specificity: Broadly expressed

        SABiosciences Custom PCR Arrays for SUMO2
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO2

    Orthologs
    for SUMO2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SUMO2 gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SUMO21 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 91.58(n)
    100(a)    		   770125  NM_001080717.2  NP_001074186.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 100(a)
    		 1 → many
    		 2(114742718-114750546)
    African clawed frog
    (Xenopus laevis)    		 Amphibia smt3h2-prov2 SMT3 suppressor of mif two 3 homolog 2 (yeast) 80.08(n)    BC045271.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sumo2b1 SMT3 suppressor of mif two 3 homolog 2b 81.72(n)
    98.92(a)    		   445027  NM_001003422.2  NP_001003422.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta smt36
    		 smt3
    		 70(a)
    		 1 → many
    		 2L(6966780-6967644)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SUM16
    SUMO 26
    (see all 7)    		 small ubiquitin-related modifier 2
    (see all 7)    		 47(a)
    41(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 4(13497326-13498730)
    5(22383560-22384925)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 ubiquitin family domain containing protein, expres...
    ubiquitin family domain containing protein, expres...
    		 48(a)
    48(a)
    		 many ↔ many
    many ↔ many
    		 1(40060804-40062480)
    1(40063602-40065230)


    ENSEMBL Gene Tree for SUMO2 (if available)
    TreeFam Gene Tree for SUMO2 (if available) 

    Paralogs
    for SUMO2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUMO2 gene
    ENSG000002285322  SUMO42  SUMO12  SUMO32  
    4 SIMAP similar genes for SUMO2 using alignment to 2 protein entries:     SUMO2_HUMAN (see all proteins):
    SUMO3    SUMO4    SUMO1    NFATC2IP

    SUMO2 for paralogs           About GeneDecksing


    5/27 Pseudogenes.org Pseudogenes for SUMO2 (see all 27)
    PGOHUM00000247095 PGOHUM00000237102 PGOHUM00000237432 PGOHUM00000235051 PGOHUM00000263121


    Genomic Variants
    for SUMO2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/308 NCBI SNPs in SUMO2 are shown (see all 308)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1501391171,2
    		--73163541(+) CCCTAC/TGCTCC 2 -- ds50010--------
    rs1924522641,2
    		--73163546(+) TGCTCC/TGTGCC 2 -- ds50010--------
    rs1385587451,2
    		--73163676(+) AAACTA/GTTATT 2 -- ds50010--------
    rs1825445991,2
    		--73163738(+) CCTTCG/TTGAAA 2 -- ds50010--------
    rs620850301,2
    		--73163739(+) CTTCTT/GGAAAT 2 -- ds50012Minor allele frequency- G:0.02NA 122
    rs21270811,2
    		C,H--73163777(+) TTTTTC/TTAAGC 2 -- ds50015Minor allele frequency- T:0.00NS EA NA 420
    rs1180661021,2
    		--73163808(+) TTCTCA/GGAATA 2 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1880562651,2
    		--73163921(+) CCCTAA/CTTAAA 2 -- ut310--------
    rs604091601,2
    		C--73164227(+) AAAAA-/ATGCAA 2 -- ut311Minor allele frequency- A:0.50NA 2
    rs84201,2
    		C--73164318(-) GTTTTC/TTCTAT 2 -- ut313Minor allele frequency- T:0.00NA EA 252

    HapMap Linkage Disequilibrium report for SUMO2 (73163408 - 73179098 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SUMO2
         1 CNV: 35499

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    Disorders / Diseases
    for SUMO2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SUMO2 for disorders           About GeneDecksing

    OMIM gene information: 603042    OMIM disorders: --

    13 diseases for SUMO2:    About MalaCards
    transient cerebral ischemia    herpes simplex    kaposi's sarcoma    huntington's disease
    liver disease    sarcoma    ischemia    ataxia
    cerebritis    hypoxia    immunodeficiency    malaria
    leukemia


    Export disorders for SUMO2 gene to outside databases

    Publications
    for SUMO2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUMO2 gene, integrated from 9 sources (see all 171):
    (articles sorted by number of sources associating them with SUMO2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene. (PubMed id 8630065)1, 2, 3 Mannen H.... Li S.S.-L. (1996)
    2. Characterization of a second member of the sentrin family of ubiquitin-like proteins. (PubMed id 9556629)1, 2, 9 Kamitani T.... Yeh E.T.H. (1998)
    3. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PubMed id 12383504)1, 2, 9 Su H.-L. and Li S.S.-L. (2002)
    4. Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins. (PubMed id 15479240)1, 2, 9 Huang W.-C.... Wang A.H.-J. (2004)
    5. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PubMed id 15296745)1, 2, 9 Reverter D. and Lima C.D. (2004)
    6. Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. (PubMed id 11451954)1, 2, 9 Tatham M.H.... Hay R.T. (2001)
    7. Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. (PubMed id 18538659)1, 2 Meulmeester E....Melchior F. (2008)
    8. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. (PubMed id 18408734)1, 2 Tatham M.H....Hay R.T. (2008)
    9. Crystal structure of SUMO-3-modified thymine-DNA glycosylase. (PubMed id 16626738)1, 2 Baba D.... Shirakawa M. (2006)
    10. NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. (PubMed id 16567619)1, 2 Rosendorff A.... Gill G. (2006)

    External Searches for SUMO2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing SUMO2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6613 HGNC: 11125 AceView: SUMO2andHN1 Ensembl:ENSG00000188612 euGenes: HUgn6613
    ECgene: SUMO2 Kegg: 6613 H-InvDB: SUMO2

    Other Databases showing SUMO2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SUMO2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUMO2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/SUMO_protein

    Intellectual Property
    for SUMO2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SUMO2 gene:
    Search GeneIP for patents involving SUMO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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