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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUMO2 Gene

protein-coding   GIFtS: 61
GCID: GC17M073163

Small Ubiquitin-Like Modifier 2

(Previous names: SMT3 (suppressor of mif two 3, yeast) homolog 2, SMT3 suppressor...)
(Previous symbol: SMT3H2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Small Ubiquitin-Like Modifier 21 2     SUMO32
SMT3H21 2 3     Sentrin 22
Ubiquitin-Like Protein SMT3A2 3     Small Ubiquitin-Related Modifier 22
HSMT32 3     SMT3 Suppressor Of Mif Two 3 Homolog 22
Smt3A2 3     Ubiquitin-Like Protein SMT3B2
SMT3 Homolog 22 3     SMT3A3
SMT3 (Suppressor Of Mif Two 3, Yeast) Homolog 21     SUMO-23
SMT3 Suppressor Of Mif Two 3 Homolog 2 (S. Cerevisiae)1     SUMO-33
SMT3 Suppressor Of Mif Two 3 Homolog 2 (Yeast)1     Sentrin-23
SMT3B2     

External Ids:    HGNC: 111251   Entrez Gene: 66132   Ensembl: ENSG000001886127   OMIM: 6030425   UniProtKB: P619563   

Export aliases for SUMO2 gene to outside databases

Previous GC identifers: GC17M073761 GC17M070675 GC17M068573


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUMO2 Gene:
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It
functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational
modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved
in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein
stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off.
Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding
different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for SUMO2 Gene: 
SUMO2 (small ubiquitin-like modifier 2) is a protein-coding gene. Diseases associated with SUMO2 include transient cerebral ischemia, and myocarditis, and among its related super-pathways are Proteolytic Processing of SUMO and Wnt signaling pathway. GO annotations related to this gene include protein binding and ubiquitin protein ligase binding. An important paralog of this gene is ENSG00000228532.

UniProtKB/Swiss-Prot: SUMO2_HUMAN, P61956
Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked
polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex
SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or
CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of
cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.
Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal
degradation of modified proteins

Gene Wiki entry for SUMO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUMO2 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUMO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SUMO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUMO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

SUMO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUMO2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M073163:  view genomic region     (about GC identifiers)

Start:
73,163,408 bp from pter      End:
73,179,098 bp from pter
Size:
15,691 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SUMO2_HUMAN, P61956 (See protein sequence)
Recommended Name: Small ubiquitin-related modifier 2 precursor  
Size: 95 amino acids; 10871 Da
Subunit: Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the
biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number
of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1,
CASP8AP2, RNF111 AND SOBP (via SIM domains)
Subcellular location: Nucleus. Nucleus, PML body
Caution: Frequently wrongly assigned as SMT3B in many databases and publications. However, according to initial
nomenclature, SUMO2 corresponds to SMT3A (PubMed:10692421)
6/13 PDB 3D structures from and Proteopedia for SUMO2 (see all 13):
1WM2 (3D)        1WM3 (3D)        1WZ0 (3D)        1Z5Q (3D)        2AWT (3D)        2CKH (3D)    
Secondary accessions: B2R4I2 P55855 Q32Q42 Q6IPZ6 Q96HK1
Alternative splicing: 2 isoforms:  P61956-1   P61956-2   

Explore the universe of human proteins at neXtProt for SUMO2: NX_P61956

Explore proteomics data for SUMO2 at MOPED 

Post-translational modifications:

  • UniProtKB: Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-,
    'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4
  • UniProtKB: Cleavage of precursor form by SENP1 or SENP2 is necessary for function
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61956

  • SUMO2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SUMO2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001005849.1  NP_008868.3  

    ENSEMBL proteins: 
     ENSP00000405965   ENSP00000400886   ENSP00000461997  
    Reactome Protein details: P61956
    Human Recombinant Protein Products for SUMO2: 
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    OriGene Protein Over-expression Lysate for SUMO2
    OriGene MassSpec for SUMO2 
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    Novus Biologicals SUMO2 Proteins
    Novus Biologicals SUMO2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SUMO2
    Cloud-Clone Corp. Proteins for SUMO2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0016605PML body IDA--

    SUMO2 for ontologies           About GeneDecksing



    SUMO2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SUMO2
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    LSBio Antibodies in human, mouse, rat for SUMO2 

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    Cloud-Clone Corp. CLIAs for SUMO2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR022617 SUMO
     IPR027218 SUMO_chordates
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry P61956

    ProtoNet protein and cluster: P61956

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: SUMO2_HUMAN, P61956
    Similarity: Belongs to the ubiquitin family. SUMO subfamily
    Similarity: Contains 1 ubiquitin-like domain


    SUMO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUMO2_HUMAN, P61956
    Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked
    polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex
    SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or
    CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of
    cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.
    Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal
    degradation of modified proteins

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15383276
    GO:0031625ubiquitin protein ligase binding IPI18408734
         
    SUMO2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SUMO2:
     High actin ratio cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SUMO2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SUMO2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUMO2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUMO2 

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    hsa-miR-411* hsa-miR-379* hsa-miR-624 hsa-miR-340 hsa-miR-515-5p hsa-miR-1265 hsa-miR-3613-3p hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidSUMO2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of SUMO2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SUMO2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SUMOylation
    SUMOylation0.67
    Processing and Activation of SUMO0.67
    Proteolytic Processing of SUMO0.67
    Conjugation of SUMO to E1 (UBA2:SAE1)0.56
    2Wnt signaling pathway
    Wnt Signaling Pathway NetPath0.37
    3RNA transport
    RNA transport
    4Protein Stability
    Protein Stability
    5Glucocorticoid receptor regulatory network
    Glucocorticoid receptor regulatory network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SUMO2
        Protein Stability

    2 BioSystems Pathways for SUMO2
        Wnt Signaling Pathway NetPath
    Glucocorticoid receptor regulatory network


    4        Reactome Pathways for SUMO2
        Conjugation of SUMO to E1 (UBA2:SAE1)
    SUMOylation
    Processing and Activation of SUMO
    Proteolytic Processing of SUMO


    1         Kegg Pathway  (Kegg details for SUMO2):
        RNA transport


    SUMO2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SUMO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1263 Interacting proteins for SUMO2 (P619561, 2, 3 ENSP000004059654) via UniProtKB, MINT, STRING, and/or I2D (see all 1263)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000232804P081073, ENSP000003930874I2D: score=1 STRING: ENSP00000393087
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016925protein sumoylation TAS--
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA18408734

    SUMO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUMO2

    Search CenterWatch for drugs/clinical trials and news about SUMO2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUMO2 gene (2 alternative transcripts): 
    NM_001005849.1  NM_006937.3  

    Unigene Clusters for SUMO2:

    SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
    Hs.380973  [show with all ESTs], Hs.546298  [show with all ESTs]
    Unigene Representative Sequences: BM475081, BC008450
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420826(uc002jne.3 uc002jnf.3) ENST00000314523 ENST00000578238

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate SUMO2 (see all 21):
    hsa-miR-411* hsa-miR-379* hsa-miR-624 hsa-miR-340 hsa-miR-515-5p hsa-miR-1265 hsa-miR-3613-3p hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidSUMO2 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUMO2
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SUMO2

    Additional mRNA sequence: 

    AK024823.1 AK225090.1 BC008450.1 BC016775.1 BC022340.1 BC062713.1 BC068465.1 BC070159.1 
    BC071645.1 BC071646.1 BC107853.1 X99585.1 

    24/39 DOTS entries (see all 39):

    DT.448801  DT.91952483  DT.95344890  DT.92056459  DT.91775567  DT.95275187  DT.92373823  DT.100886022 
    DT.91871643  DT.121291596  DT.121390529  DT.102838661  DT.91775554  DT.100767787  DT.91917384  DT.120997915 
    DT.95275223  DT.100041704  DT.100043737  DT.100886010  DT.100886013  DT.121291601  DT.95275009  DT.100886021 

    24/1667 AceView cDNA sequences (see all 1667):

    AA731417 H89345 BF594429 CR601210 AW007563 AI349354 AI076922 BQ071663 
    CR605576 CD368239 BQ064235 AI014694 CB124223 BQ950381 AI608809 BQ637973 
    BF433059 BQ961444 BU687909 AF266846 L76416 CR592678 AA310437 BP368862 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUMO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGGCAATC
    SUMO2 Expression
    About this image


    See SUMO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUMO2

    SOURCE GeneReport for Unigene clusters: Hs.380973 Hs.546298

    UniProtKB/Swiss-Prot: SUMO2_HUMAN, P61956
    Tissue specificity: Broadly expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SUMO2 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sumo21 , 5 SMT3 suppressor of mif two 3 homolog 2 (yeast)1, 5 95.79(n)1
    100(a)1
      11 (80.84 cM)5
    1709301  NM_133354.21  NP_579932.11 
     1155231025 
    chicken
    (Gallus gallus)
    Aves SUMO21 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 91.58(n)
    100(a)
      770125  NM_001080717.2  NP_001074186.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    100(a)
    1 → many
    2(114742718-114750546)
    African clawed frog
    (Xenopus laevis)
    Amphibia smt3h2-prov2 SMT3 suppressor of mif two 3 homolog 2 (yeast) 80.08(n)    BC045271.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sumo2b1 SMT3 suppressor of mif two 3 homolog 2b 81.72(n)
    98.92(a)
      445027  NM_001003422.2  NP_001003422.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta smt36
    smt3
    73(a)
    1 → many
    2L(6966780-6967644)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMT36
    Ubiquitin-like protein of the SUMO family, conjuga...
    43(a)
    1 → many
    IV(1469400-1469705)


    ENSEMBL Gene Tree for SUMO2 (if available)
    TreeFam Gene Tree for SUMO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUMO2 gene
    ENSG000002285322  SUMO42  SUMO12  SUMO32  
    4 SIMAP similar genes for SUMO2 using alignment to 2 protein entries:     SUMO2_HUMAN (see all proteins):
    SUMO3    SUMO4    SUMO1    NFATC2IP

    SUMO2 for paralogs           About GeneDecksing


    5/27 Pseudogenes.org Pseudogenes for SUMO2 (see all 27)
    PGOHUM00000247095 PGOHUM00000237102 PGOHUM00000237432 PGOHUM00000235051 PGOHUM00000263121


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/365 SNPs in SUMO2 are shown (see all 365)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501391171,2
    C--73163541(+) CCCTAC/TGCTCC 2 -- ds50010--------
    rs1924522641,2
    --73163546(+) TGCTCC/TGTGCC 2 -- ds50010--------
    rs1385587451,2
    C--73163676(+) AAACTA/GTTATT 2 -- ds50010--------
    rs1825445991,2
    --73163738(+) CCTTCG/TTGAAA 2 -- ds50010--------
    rs620850301,2
    F--73163739(+) CTTCTT/GGAAAT 2 -- ds50012Minor allele frequency- G:0.02NA 122
    rs21270811,2
    C,H--73163777(+) TTTTTC/TTAAGC 2 -- ds50015Minor allele frequency- T:0.00NS EA NA 420
    rs1180661021,2
    C,F--73163808(+) TTCTCA/GGAATA 2 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1880562651,2
    --73163921(+) CCCTAA/CTTAAA 2 -- ut310--------
    rs2019244511,2
    --73164430(+) GTTCCC/GTTTTC 2 -- ut310--------
    rs1897306681,2
    --73164586(+) TGTACA/CTGTTC 2 -- int10--------

    HapMap Linkage Disequilibrium report for SUMO2 (73163408 - 73179098 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SUMO2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908756CNV Loss21882294
    nsv908758CNV Loss21882294
    nsv2141CNV Loss18451855
    nsv908759CNV Loss21882294
    nsv470602CNV Loss18288195

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603042    OMIM disorders: --

    14 diseases for SUMO2:    About MalaCards
    transient cerebral ischemia    myocarditis    kaposi's sarcoma    herpes simplex
    ischemia    cerebritis    liver disease    sarcoma
    hypoxia    colorectal cancer    thyroiditis    endotheliitis
    leukemia    hepatitis


    SUMO2 for disorders           About GeneDecksing


    Export disorders for SUMO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUMO2 gene, integrated from 9 sources (see all 196):
    (articles sorted by number of sources associating them with SUMO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene. (PubMed id 8630065)1, 2, 3 Mannen H.... Li S.S.-L. (1996)
    2. Characterization of a second member of the sentrin family of ubiquitin-like proteins. (PubMed id 9556629)1, 2, 9 Kamitani T.... Yeh E.T.H. (1998)
    3. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PubMed id 12383504)1, 2, 9 Su H.-L. and Li S.S.-L. (2002)
    4. Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins. (PubMed id 15479240)1, 2, 9 Huang W.-C.... Wang A.H.-J. (2004)
    5. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PubMed id 15296745)1, 2, 9 Reverter D. and Lima C.D. (2004)
    6. Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. (PubMed id 11451954)1, 2, 9 Tatham M.H.... Hay R.T. (2001)
    7. PolySUMO-binding proteins identified through a string search. (PubMed id 23086935)1, 2 Sun H. and Hunter T. (2012)
    8. Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. (PubMed id 18538659)1, 2 Meulmeester E....Melchior F. (2008)
    9. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. (PubMed id 18408734)1, 2 Tatham M.H....Hay R.T. (2008)
    10. Crystal structure of SUMO-3-modified thymine-DNA glycosylase. (PubMed id 16626738)1, 2 Baba D.... Shirakawa M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6613 HGNC: 11125 AceView: SUMO2andHN1 Ensembl:ENSG00000188612 euGenes: HUgn6613
    ECgene: SUMO2 Kegg: 6613 H-InvDB: SUMO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUMO2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/SUMO_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUMO2 gene:
    Search GeneIP for patents involving SUMO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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