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Aliases for SUMO1 Gene

Aliases for SUMO1 Gene

  • Small Ubiquitin-Like Modifier 1 2 3 5
  • Ubiquitin-Homology Domain Protein PIC1 3 4
  • Ubiquitin-Like Protein SMT3C 3 4
  • Ubiquitin-Like Protein UBL1 3 4
  • SMT3 Homolog 3 3 4
  • Sentrin 3 4
  • SMT3H3 3 4
  • SMT3C 3 4
  • UBL1 3 4
  • GMP1 3 4
  • SMT3 Suppressor Of Mif Two 3 Homolog 1 (S. Cerevisiae) 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 1 (Yeast) 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 1 3
  • Ubiquitin-Like 1 (Sentrin) 2
  • GAP Modifying Protein 1 3
  • GAP-Modifying Protein 1 4
  • SUMO-1 4
  • OFC10 3
  • SENP2 3
  • PIC1 3
  • DAP1 3
  • SMT3 3

External Ids for SUMO1 Gene

Previous HGNC Symbols for SUMO1 Gene

  • UBL1

Previous GeneCards Identifiers for SUMO1 Gene

  • GC02M203274
  • GC02M202896
  • GC02M202779
  • GC02M203070

Summaries for SUMO1 Gene

Entrez Gene Summary for SUMO1 Gene

  • This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for SUMO1 Gene

SUMO1 (Small Ubiquitin-Like Modifier 1) is a Protein Coding gene. Diseases associated with SUMO1 include orofacial cleft 10 and lip cancer. Among its related pathways are Transport to the Golgi and subsequent modification and Immune System. GO annotations related to this gene include poly(A) RNA binding and ubiquitin protein ligase binding. An important paralog of this gene is SUMO4.

UniProtKB/Swiss-Prot for SUMO1 Gene

  • Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).

Gene Wiki entry for SUMO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUMO1 Gene

Genomics for SUMO1 Gene

Regulatory Elements for SUMO1 Gene

Promoters for SUMO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SUMO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUMO1 Gene

Chromosome:
2
Start:
202,206,180 bp from pter
End:
202,238,608 bp from pter
Size:
32,429 bases
Orientation:
Minus strand

Genomic View for SUMO1 Gene

Genes around SUMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUMO1 Gene

Proteins for SUMO1 Gene

  • Protein details for SUMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63165-SUMO1_HUMAN
    Recommended name:
    Small ubiquitin-related modifier 1
    Protein Accession:
    P63165
    Secondary Accessions:
    • A8MUS8
    • B2R4I5
    • P55856
    • Q6FGG0
    • Q6NZ62
    • Q93068

    Protein attributes for SUMO1 Gene

    Size:
    101 amino acids
    Molecular mass:
    11557 Da
    Quaternary structure:
    • Covalently attached to KCNB1; UBE2I increases cross-linking with KCNB1 and PIAS1 decreases cross-links with KCNB1 (PubMed:19223394). Interacts with SAE2, RANBP2, PIAS1 and PIAS2. Interacts with PARK2. Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52. Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains). Interacts with BHLHE40/DEC1. Interacts with RWDD3. Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3. Interacts with MTA1. Interacts with Epstein-barr virus BGLF4.

    Three dimensional structures from OCA and Proteopedia for SUMO1 Gene

    Alternative splice isoforms for SUMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUMO1 Gene

Proteomics data for SUMO1 Gene at MOPED

Post-translational modifications for SUMO1 Gene

  • Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
  • Polymeric SUMO1 chains undergo polyubiquitination by RNF4.
  • Ubiquitination at Lys 25, Lys 37, and Lys 48
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SUMO1 (SUMO1)

Protein Products

No data available for DME Specific Peptides for SUMO1 Gene

Domains & Families for SUMO1 Gene

Protein Domains for SUMO1 Gene

Suggested Antigen Peptide Sequences for SUMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P63165

UniProtKB/Swiss-Prot:

SUMO1_HUMAN :
  • Contains 1 ubiquitin-like domain.
  • Belongs to the ubiquitin family. SUMO subfamily.
Domain:
  • Contains 1 ubiquitin-like domain.
Family:
  • Belongs to the ubiquitin family. SUMO subfamily.
genes like me logo Genes that share domains with SUMO1: view

No data available for Gene Families for SUMO1 Gene

Function for SUMO1 Gene

Molecular function for SUMO1 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).
genes like me logo Genes that share phenotypes with SUMO1: view

Human Phenotype Ontology for SUMO1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SUMO1 Gene

MGI Knock Outs for SUMO1:

Animal Model Products

miRNA for SUMO1 Gene

miRTarBase miRNAs that target SUMO1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for SUMO1 Gene

Localization for SUMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUMO1 Gene

Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Cell membrane. Nucleus. Note=Recruited by BCL11A into the nuclear body. In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body. {ECO:0000250 UniProtKB:P63166, ECO:0000269 PubMed:24651376}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUMO1 Gene COMPARTMENTS Subcellular localization image for SUMO1 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SUMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore TAS 9019411
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005886 plasma membrane IDA 19223394
GO:0016605 colocalizes_with PML body IDA 9412458
genes like me logo Genes that share ontologies with SUMO1: view

Pathways & Interactions for SUMO1 Gene

genes like me logo Genes that share pathways with SUMO1: view

Gene Ontology (GO) - Biological Process for SUMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006289 nucleotide-excision repair TAS --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0016032 viral process IEA --
GO:0016925 protein sumoylation TAS --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with SUMO1: view

No data available for SIGNOR curated interactions for SUMO1 Gene

Drugs & Compounds for SUMO1 Gene

(9) Drugs for SUMO1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for SUMO1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SUMO1: view

Transcripts for SUMO1 Gene

Unigene Clusters for SUMO1 Gene

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUMO1 Gene

No ASD Table

Relevant External Links for SUMO1 Gene

GeneLoc Exon Structure for
SUMO1
ECgene alternative splicing isoforms for
SUMO1

Expression for SUMO1 Gene

mRNA expression in normal human tissues for SUMO1 Gene

Protein differential expression in normal tissues from HIPED for SUMO1 Gene

This gene is overexpressed in Heart (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUMO1 Gene



SOURCE GeneReport for Unigene cluster for SUMO1 Gene Hs.81424

genes like me logo Genes that share expression patterns with SUMO1: view

Protein tissue co-expression partners for SUMO1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SUMO1 Gene

Orthologs for SUMO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUMO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUMO1 35
  • 96.7 (n)
  • 100 (a)
SUMO1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUMO1 35
  • 97.36 (n)
  • 99.01 (a)
SUMO1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sumo1 35
  • 95.71 (n)
  • 100 (a)
Sumo1 16
Sumo1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUMO1 35
  • 99.67 (n)
  • 100 (a)
SUMO1 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sumo1 35
  • 94.39 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia SUMO1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUMO1 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUMO1 35
  • 91.42 (n)
  • 98.02 (a)
SUMO1 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SUMO1 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sumo1 35
  • 82.18 (n)
  • 94.06 (a)
African clawed frog
(Xenopus laevis)
Amphibia SUMO-1 35
zebrafish
(Danio rerio)
Actinopterygii hmzeh0670 35
sumo1 35
  • 78.12 (n)
  • 87.5 (a)
sumo1 36
  • 84 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea smo-1 35
  • 59.07 (n)
  • 65.82 (a)
smo-1 36
  • 60 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMT3 36
  • 50 (a)
OneToMany
Species with no ortholog for SUMO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUMO1 Gene

ENSEMBL:
Gene Tree for SUMO1 (if available)
TreeFam:
Gene Tree for SUMO1 (if available)

Paralogs for SUMO1 Gene

Paralogs for SUMO1 Gene

genes like me logo Genes that share paralogs with SUMO1: view

Variants for SUMO1 Gene

Sequence variations from dbSNP and Humsavar for SUMO1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1050860 -- 202,206,799(-) CTTTT(A/T)AAATT utr-variant-3-prime
rs1804594 -- 202,206,905(-) TCTAG(A/C)ATGTG intron-variant, utr-variant-3-prime
rs2176167 -- 202,236,195(+) tagaa(C/T)cccat intron-variant
rs2176168 -- 202,236,216(+) ttagg(C/T)tggtt intron-variant
rs2350359 -- 202,215,624(+) TGCCT(A/G)TAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUMO1 Gene

Variant ID Type Subtype PubMed ID
nsv834512 CNV Loss 17160897
esv2491134 CNV Deletion 19546169

Variation tolerance for SUMO1 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUMO1 Gene

HapMap Linkage Disequilibrium report
SUMO1
Human Gene Mutation Database (HGMD)
SUMO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUMO1 Gene

Disorders for SUMO1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for SUMO1 Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
orofacial cleft 10
  • orofacial cleft10
lip cancer
  • malignant neoplasm of commissure of lip
neuronal intranuclear inclusion disease
  • neuronal intranuclear hyaline inclusion disease
orofacial cleft
cleft lip
  • cheiloschisis
- elite association - COSMIC cancer census association via MalaCards
Search SUMO1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SUMO1_HUMAN
  • Non-syndromic orofacial cleft 10 (OFC10) [MIM:613705]: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. {ECO:0000269 PubMed:16990542}. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays.

Relevant External Links for SUMO1

Genetic Association Database (GAD)
SUMO1
Human Genome Epidemiology (HuGE) Navigator
SUMO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUMO1
genes like me logo Genes that share disorders with SUMO1: view

No data available for Genatlas for SUMO1 Gene

Publications for SUMO1 Gene

  1. UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins. (PMID: 8812453) Shen Z. … Chen D.J. (Genomics 1996) 2 3 4 23 67
  2. Association of SUMO1 and UBC9 genotypes with tumor response in non-small-cell lung cancer treated with irinotecan-based chemotherapy. (PMID: 19859084) Han J.Y. … Lee J.S. (Pharmacogenomics J. 2010) 3 23
  3. Small ubiquitin-like modifier 1 [corrected] mediates the resistance of prosthesis-loosening fibroblast-like synoviocytes against Fas-induced apoptosis. (PMID: 19565496) Meinecke I. … Peters M.A. (Arthritis Rheum. 2009) 3 23
  4. In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy. (PMID: 17938407) Matic I. … Vertegaal A.C. (Mol. Cell Proteomics 2008) 3 23
  5. In human pachytene spermatocytes, SUMO protein is restricted to the constitutive heterochromatin. (PMID: 18592385) Metzler-Guillemain C. … Mattei M.G. (Chromosome Res. 2008) 3 23

Products for SUMO1 Gene

Sources for SUMO1 Gene

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