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SUMO1 Gene

protein-coding   GIFtS: 68
GCID: GC02M203070

Small Ubiquitin-Like Modifier 1

(Previous names: ubiquitin-like 1 (sentrin), SMT3 suppressor of mif two 3...)
(Previous symbol: UBL1)
  See SUMO1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Small Ubiquitin-Like Modifier 11 2     Ubiquitin-Like 1 (Sentrin)1
UBL11 2 3 5     DAP12
Ubiquitin-Homology Domain Protein PIC12 3     PIC12
Ubiquitin-Like Protein SMT3C2 3     SENP22
Ubiquitin-Like Protein UBL12 3     GAP Modifying Protein 12
GMP12 3     sentrin2
SMT3C2 3     Small Ubiquitin-Related Modifier 12
SMT3H32 3     SMT3 Suppressor Of Mif Two 3 Homolog 12
SMT3 Homolog 32 3     SUMO-13
OFC102 5     Sentrin3
SMT32 5     Smt3C3
SMT3 Suppressor Of Mif Two 3 Homolog 1 (S. Cerevisiae)1     GAP-Modifying Protein 13
SMT3 Suppressor Of Mif Two 3 Homolog 1 (Yeast)1     

External Ids:    HGNC: 125021   Entrez Gene: 73412   Ensembl: ENSG000001160307   OMIM: 6019125   UniProtKB: P631653   

Export aliases for SUMO1 gene to outside databases

Previous GC identifers: GC02M203274 GC02M202896 GC02M202779


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SUMO1 Gene:
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It
functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational
modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved
in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein
stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off.
Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding
different isoforms have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for SUMO1 Gene:
SUMO1 (small ubiquitin-like modifier 1) is a protein-coding gene. Diseases associated with SUMO1 include orofacial cleft10, and neuronal intranuclear inclusion disease. GO annotations related to this gene include SUMO ligase activity and transcription factor binding. An important paralog of this gene is SUMO2.

UniProtKB/Swiss-Prot: SUMO1_HUMAN, P63165
Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked
polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex
SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4.
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular
processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for
instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also
susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
May also regulate a network of genes involved in palate development

Gene Wiki entry for SUMO1 (Small ubiquitin-related modifier 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUMO1 gene promoter:
         CREB   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUMO1 promoter sequence
   Search Chromatin IP Primers for SUMO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUMO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33

SUMO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUMO1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M203070:  view genomic region     (about GC identifiers)

Start:
203,070,903 bp from pter      End:
203,103,331 bp from pter
Size:
32,429 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SUMO1_HUMAN, P63165 (See protein sequence)
Recommended Name: Small ubiquitin-related modifier 1 precursor  
Size: 101 amino acids; 11557 Da
Subunit: Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Interacts with PARK2. Covalently attached to a
number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also
interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52. Interacts with USP25 (via ts SIM domain); the
interaction weakly sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains)
Selected PDB 3D structures from and Proteopedia for SUMO1 (see all 20):
1A5R (3D)        1TGZ (3D)        1WYW (3D)        1Y8R (3D)        1Z5S (3D)        2ASQ (3D)    
Secondary accessions: A8MUS8 B2R4I5 P55856 Q6FGG0 Q6NZ62 Q93068
Alternative splicing: 2 isoforms:  P63165-1   P63165-2   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for SUMO1: NX_P63165

Explore proteomics data for SUMO1 at MOPED

Post-translational modifications: 

  • Cleavage of precursor form by SENP1 or SENP2 is necessary for function1
  • Polymeric SUMO1 chains undergo polyubiquitination by RNF41
  • Ubiquitination2 at Lys7, Lys25, Lys37, Lys48
  • Modification sites at PhosphoSitePlus

  • See SUMO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001005781.1  NP_001005782.1  NP_003343.1  

    ENSEMBL proteins: 
     ENSP00000376077   ENSP00000387204   ENSP00000376075   ENSP00000386296   ENSP00000386753  
     ENSP00000386472   ENSP00000386267   ENSP00000386500   ENSP00000376076  
    Reactome Protein details: P63165

    SUMO1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant SUMO1 Protein
    R&D Systems Recombinant & Natural Proteins for SUMO1
    Enzo Life Sciences proteins for SUMO1
    OriGene Purified Protein for SUMO1
    OriGene Protein Over-expression Lysate for SUMO1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SUMO1
    GenScript Custom Purified and Recombinant Proteins Services for SUMO1
    Novus Biologicals SUMO1 Proteins
    Novus Biologicals SUMO1 Lysates
    Sino Biological Recombinant Protein for SUMO1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SUMO1
    Cloud-Clone Corp. Proteins for SUMO1

     
    Search eBioscience for Proteins for SUMO1 

    SUMO1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SUMO1
    R&D Systems Antibodies for SUMO1
    Cell Signaling Technology (CST) Antibodies for SUMO1 
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    OriGene Custom Antibody Services for SUMO1
    Novus Biologicals SUMO1 Antibodies
    Abcam antibodies for SUMO1
    Cloud-Clone Corp. Antibodies for SUMO1
    ThermoFisher Antibody for SUMO1
    LSBio Antibodies in human, mouse, rat for SUMO1

    SUMO1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Ubiquitin Proteasome Pathway (UPP) Assay Kits & Reagents for SUMO1
    GenScript Custom Assay Services for SUMO1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SUMO1
    Cloud-Clone Corp. CLIAs for SUMO1
    Search eBioscience for ELISAs for SUMO1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000626 Ubiquitin_dom

    Graphical View of Domain Structure for InterPro Entry P63165

    ProtoNet protein and cluster: P63165

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: SUMO1_HUMAN, P63165
    Similarity: Belongs to the ubiquitin family. SUMO subfamily
    Similarity: Contains 1 ubiquitin-like domain


    Find genes that share domains with SUMO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUMO1_HUMAN, P63165
    Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked
    polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex
    SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4.
    This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular
    processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for
    instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also
    susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
    May also regulate a network of genes involved in palate development

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11112409
    GO:0008134transcription factor binding IEA--
    GO:0019789SUMO ligase activity IEA--
    GO:0031625ubiquitin protein ligase binding IPI18408734
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SUMO1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SUMO1:
     Increased homologous recombina 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sumo1):
     cellular  craniofacial  digestive/alimentary  mortality/aging  normal 

    Find genes that share phenotypes with SUMO1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sumo1tm1Oaj for SUMO1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SUMO1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SUMO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SUMO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SUMO1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SUMO1:
    hsa-mir-877-3p (MIRT036934)

    Block miRNA regulation of human, mouse, rat SUMO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SUMO1 (see all 15):
    hsa-miR-21* hsa-miR-323-3p hsa-miR-520d-5p hsa-miR-133b hsa-miR-3133 hsa-miR-3692 hsa-miR-570 hsa-miR-146a*
    SwitchGear 3'UTR luciferase reporter plasmidSUMO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SUMO1
    Predesigned siRNA for gene silencing in human, mouse, rat SUMO1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SUMO1

    Clone
    Products:
         
    OriGene clones in human, mouse for SUMO1 (see all 18)
    OriGene ORF clones in mouse, rat for SUMO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SUMO1 (NM_003352)
    Sino Biological Human cDNA Clone for SUMO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUMO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUMO1
    Addgene plasmids for SUMO1 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SUMO1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUMO1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12205) for SUMO1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SUMO1_HUMAN, P63165: Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Note=Recruited by BCL11A
    into the nuclear body (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005643nuclear pore TAS9019411
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with SUMO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SUMO1 About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1Processing and Activation of SUMO
    Processing and Activation of SUMO
    SUMOylation0.00
    Conjugation of SUMO to E1 (UBA2-SAE1)0.00
    Proteolytic Processing of SUMO0.00
    Transfer of SUMO from E1 to E2 (UBE2I, UBC9)0.00
    2Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    Regulation of IFNG signaling0.00
    3Proteolysis Putative SUMO 1 pathway
    DNA damage Role of SUMO in p53 regulation0.33
    Proteolysis Putative SUMO 1 pathway0.33
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    5TNF Signaling
    NF-kB (NFkB) Pathway0.46


    Find genes that share SuperPaths with SUMO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SUMO1
        AHR Pathway
    Glucocorticoid Receptor Signaling
    JAK-STAT Pathway
    SUMO Pathway
    Fas Signaling

    1 Cell Signaling Technology (CST) Pathway for SUMO1
        Protein Stability

    Selected GeneGo (Thomson Reuters) Pathways for SUMO1 (see all 6)
        Proteolysis Putative SUMO-1 pathway
    Transcription P53 signaling pathway
    Apoptosis and survival FAS signaling cascades
    Transcription NF-kB signaling pathway
    DNA damage Role of SUMO in p53 regulation

    Selected BioSystems Pathways for SUMO1 (see all 9)
        Diurnally regulated genes with circadian orthologs
    TP53 network
    TGF-beta Receptor Signaling Pathway
    Androgen receptor signaling pathway
    Wnt Signaling Pathway NetPath

    1 Sino Biological Pathway for SUMO1
        NF-kB (NFkB) Pathway

    4 Reactome Pathways for SUMO1
        Regulation of IFNG signaling
    SUMO is transferred from E1 to E2 (UBE2I, UBC9)
    SUMO is conjugated to E1 (UBA2:SAE1)
    SUMO is proteolytically processed


    1 Kegg Pathway  (Kegg details for SUMO1):
        RNA transport

        Pathway & Disease-focused RT2 Profiler PCR Array including SUMO1: 
              DNA Damage Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SUMO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SUMO1 (P631651, 2, 3 ENSP000003760764) via UniProtKB, MINT, STRING, and/or I2D (see all 1305)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=14 STRING: ENSP00000352980
    HIST1H4CP628053, ENSP000003670344I2D: score=14 STRING: ENSP00000367034
    HIST1H4DP628053, ENSP000003432824I2D: score=14 STRING: ENSP00000343282
    HIST1H4EP628053, ENSP000003536244I2D: score=14 STRING: ENSP00000353624
    HIST1H4HP628053, ENSP000002893524I2D: score=14 STRING: ENSP00000289352
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS8812453
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0016925protein sumoylation TAS--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0030578PML body organization IEA--

    Find genes that share ontologies with SUMO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUMO1

    Selected Novoseek inferred chemical compound relationships for SUMO1 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pic 1 90.5 19 9465300 (5), 9658103 (4), 12379236 (2), 9360969 (1) (see all 5)
    lysine 67.7 28 11259410 (3), 15958389 (2), 11264375 (2), 15613319 (1) (see all 17)
    arginine 22.3 2 16120648 (1), 12200128 (1)
    testosterone 21.2 7 11121022 (2), 19116244 (1), 14609956 (1), 12177000 (1)
    camptothecin 10.8 4 12439742 (2), 16428803 (2)
    glutamine 10.6 11 12488827 (4), 16409557 (1)
    progesterone 8.9 4 14500579 (2), 12529333 (1)
    zinc 7.94 2 14527952 (1), 18655774 (1)
    gdp 2.93 2 16562673 (1), 15952105 (1)
    retinoic acid 1.71 1 9756909 (1)



    Find genes that share compounds with SUMO1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SUMO1 gene (3 alternative transcripts): 
    NM_001005781.1  NM_001005782.1  NM_003352.4  

    Unigene Cluster for SUMO1:

    SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
    Hs.81424  [show with all ESTs]
    Unigene Representative Sequence: BF214482
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392246(uc002uyz.1 uc002uza.1) ENST00000409368 ENST00000392244
    ENST00000409712 ENST00000409181 ENST00000409498 ENST00000409205 ENST00000409627
    ENST00000469034 ENST00000392245
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SUMO1 (see all 15):
    hsa-miR-21* hsa-miR-323-3p hsa-miR-520d-5p hsa-miR-133b hsa-miR-3133 hsa-miR-3692 hsa-miR-570 hsa-miR-146a*
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SUMO1 (NM_003352)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SUMO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SUMO1
    Addgene plasmids for SUMO1 
    Primer
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    OriGene qPCR primer pairs and template standards for SUMO1
    OriGene qSTAR qPCR primer pairs in human, mouse for SUMO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SUMO1
      QuantiTect SYBR Green Assays in human, mouse, rat SUMO1
      QuantiFast Probe-based Assays in human, mouse, rat SUMO1
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12205) for SUMO1 

    Additional mRNA sequence: 

    AB062294.1 AK311840.1 BC005899.1 BC006462.1 BC053528.1 BC066306.1 BT006632.1 CR542147.1 
    CR542156.1 U38784.1 U61397.1 U67122.1 U72722.1 U83117.1 X99586.1 

    Selected DOTS entries (see all 27):

    DT.91879933  DT.100855185  DT.100855196  DT.95365185  DT.99968800  DT.100031322  DT.121428660  DT.446856 
    DT.95365183  DT.120982190  DT.121428730  DT.95365191  DT.100855188  DT.100855192  DT.120982180  DT.120982198 
    DT.92460108  DT.95365194  DT.95365199  DT.100855186  DT.92460102  DT.92460104  DT.95365209  DT.120982148 

    Selected AceView cDNA sequences (see all 598):

    BM312362 BU622518 BU686311 AI080094 CA489516 CR621661 CB994943 AW152389 
    BQ435391 D31282 BM661837 BE646551 AV711823 AA605140 BE042427 CR591769 
    BI905857 N23177 AI149800 CB107274 AI497718 AI193585 BC066306 AI862855 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SUMO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAAATGAA
    SUMO1 Expression
    About this image


    SUMO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    SUMO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUMO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.81424
        Pathway & Disease-focused RT2 Profiler PCR Array including SUMO1: 
              DNA Damage Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SUMO1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sumo11 , 5 SMT3 suppressor of mif two 3 homolog 1 (yeast)1, 5 95.71(n)1
    100(a)1
      1 (30.32 cM)5
    222181  NM_009460.21  NP_033486.11 
     596394345 
    chicken
    (Gallus gallus)
    Aves SUMO11 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 91.42(n)
    98.02(a)
      373930  NM_204135.2  NP_989466.1 
    lizard
    (Anolis carolinensis)
    Reptilia SUMO16
    small ubiquitin-like modifier 1
    96(a)
    1 ↔ 1
    GL343208.1(3672955-3862654)
    African clawed frog
    (Xenopus laevis)
    Amphibia SUMO-12 SUMO-1 protein 80.29(n)    Z97073.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmzeh06702 Danio rerio cDNA clone MGC65934 IMAGE6790208, complete more 77.48(n)    BC056283.1 
    worm
    (Caenorhabditis elegans)
    Secernentea smo-11 smo-1 59.07(n)
    65.82(a)
      266820  NM_058441.4  NP_490842.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMT36
    Ubiquitin-like protein of the SUMO family, conjuga...
    50(a)
    1 → many
    IV(1469400-1469705) YDR510W


    ENSEMBL Gene Tree for SUMO1 (if available)
    TreeFam Gene Tree for SUMO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUMO1 gene
    SUMO22  ENSG000002285322  SUMO42  SUMO32  
    Selected SIMAP similar genes for SUMO1 using alignment to 6 protein entries:     SUMO1_HUMAN (see all proteins) (see all similar genes):
    HC6    HBP1    RPGRIP1L    TNNT1    SIPA1L3    AAMDC
    NAE1    COQ5    MST132    C4BPB    CALCOCO2    DPP9
    LSM12    FLJ00047    NDC80    SEPSECS    SUMO2    IRF5

    Find genes that share paralogs with SUMO1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for SUMO1 (see all 13)
    PGOHUM00000242374 PGOHUM00000242598 PGOHUM00000237385 PGOHUM00000234734 PGOHUM00000244800


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SUMO1 (see all 648)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs613129421,2
    C--202460370(+) AAAAA-/AAAAAA/AAAAA
    AA
    /AAAAAAAAAAAA
    GATAT
    9 -- ds5001 cds11NA 2
    rs129910141,2
    C,H--202460583(+) TATTGT/GGGCCT 3 -- ut31 ese34Minor allele frequency- G:0.00NS EA 420
    rs729230151,2
    --202460767(+) AAGCAA/TTAGTA 3 -- ut310--------
    rs1492695521,2
    C--202461119(+) GGTCAC/TTTTTC 3 -- ut31 int10--------
    rs1831878671,2
    --202461214(+) GCCAAC/TTGGAA 3 -- ut31 int10--------
    rs1452844271,2
    --202461261(+) ATCACC/TACAAG 3 -- ut31 int10--------
    rs1878503731,2
    --202461766(+) AAGAAC/TATAGA 3 -- int10--------
    rs1926173301,2
    --202461792(+) GATTCC/TGTCTA 3 -- int10--------
    rs1836984641,2
    --202461855(+) CTATAC/TAAAAC 3 -- int10--------
    rs1876668021,2
    --202462025(+) TGGCAC/TAATCT 3 -- int10--------

    HapMap Linkage Disequilibrium report for SUMO1 (203070903 - 203103331 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SUMO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2491134CNV Deletion19546169
    nsv834512CNV Loss17160897

    Human Gene Mutation Database (HGMD): SUMO1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUMO1
    DNA2.0 Custom Variant and Variant Library Synthesis for SUMO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601912   
    OMIM disorders: 613705  
    UniProtKB/Swiss-Prot: SUMO1_HUMAN, P63165
  • Non-syndromic orofacial cleft 10 (OFC10) [MIM:613705]: A birth defect consisting of cleft lips with or
    without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on
    one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip
    extending into the floor of the nostril and involving the upper gum. Note=The disease is caused by mutations
    affecting the gene represented in this entry. A chromosomal aberration involving SUMO1 is the cause of OFC10.
    Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency
    confirmed by protein assays

  • 5 diseases for SUMO1:    
    About MalaCards
    orofacial cleft10    neuronal intranuclear inclusion disease    cortisol resistance    orofacial cleft
    familial partial lipodystrophy


    Find genes that share disorders with SUMO1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SUMO1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 74 15 14527952 (2), 17060459 (1), 16287851 (1), 15707587 (1) (see all 7)
    leukemia promyelocytic acute 46.1 1 9465300 (1)
    bloom syndrome 35.9 1 11500040 (1)
    leukemia 14.4 5 16409557 (1), 16125395 (1), 11080164 (1), 16401619 (1)
    rheumatoid arthritis 0.0063 7 17360386 (2), 10728754 (1), 19565496 (1)
    virus infection 0 2 9658103 (2)
    necrosis 0 4 9162015 (1), 9353268 (1), 10728754 (1), 18093978 (1)
    shock 0 2 19409099 (1)
    tumors 0 13 19859084 (5), 17671677 (3), 12621041 (1), 9162015 (1) (see all 7)
    neurodegeneration 0 1 16401619 (1)

    Genetic Association Database (GAD): SUMO1
    Human Genome Epidemiology (HuGE) Navigator: SUMO1 (13 documents)

    Export disorders for SUMO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUMO1 gene, integrated from 10 sources (see all 675):
    (articles sorted by number of sources associating them with SUMO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins. (PubMed id 8812453)1, 2, 3, 9 Shen Z....Chen D.J. (Genomics 1996)
    2. Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin. (PubMed id 8906799)1, 2, 3 Okura T.... Yeh E.T.H. (J. Immunol. 1996)
    3. Structure determination of the small ubiquitin-related modifier SUMO- 1. (PubMed id 9654451)1, 2, 9 Bayer P....Becker J. (J. Mol. Biol. 1998)
    4. Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. (PubMed id 12924945)1, 2, 9 Tatham M.H.... Chen Y. (Biochemistry 2003)
    5. Preferential modification of nuclear proteins by a novel ubiquitin- like molecule. (PubMed id 9162015)1, 2, 9 Kamitani T.... Yeh E.T.H. (J. Biol. Chem. 1997)
    6. SUMO protease SENP1 induces isomerization of the scissile peptide bond. (PubMed id 17099698)1, 2, 9 Shen L.... Hay R.T. (Nat. Struct. Mol. Biol. 2006)
    7. Association of SUMO1 and UBC9 genotypes with tumor response in non-small-cell lung cancer treated with irinotecan-based chemotherapy. (PubMed id 19859084)1, 4, 9 Han J.Y....Lee J.S. (Pharmacogenomics J. 2010)
    8. Functional modulation of parkin through physical interaction with SUMO-1. (PubMed id 16955485)1, 2, 9 Um J.W. and Chung K.C. (J. Neurosci. Res. 2006)
    9. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PubMed id 12383504)1, 2, 9 Su H.-L. and Li S.S.-L. (Gene 2002)
    10. SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. (PubMed id 9119407)1, 2, 9 Lapenta V....Brahe C. (Genomics 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7341 HGNC: 12502 AceView: SUMO1 Ensembl:ENSG00000116030 euGenes: HUgn7341
    ECgene: SUMO1 Kegg: 7341 H-InvDB: SUMO1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SUMO1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SUMO1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/SUMO_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SUMO1 gene:
    Search GeneIP for patents involving SUMO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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