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SUMF2 Gene

protein-coding   GIFtS: 55
GCID: GC07P056144

Sulfatase Modifying Factor 2

  See SUMF2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sulfatase Modifying Factor 21 2
C-Alpha-Formylglycine-Generating Enzyme 22 3
C-Alpha-Formyglycine-Generating Enzyme 22
pFGE2
Paralog Of The Formylglycine-Generating Enzyme2
Sulfatase-Modifying Factor 22

External Ids:    HGNC: 204151   Entrez Gene: 258702   Ensembl: ENSG000001291037   OMIM: 6079405   UniProtKB: Q8NBJ73   

Export aliases for SUMF2 gene to outside databases

Previous GC identifers: GC07P055839 GC07P055873 GC07P055906 GC07P056099 GC07P056132 GC07P055946 GC07P056135 GC07P056139


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SUMF2 Gene:
The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine
(FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating
activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a
protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low
levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels
of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been
characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for SUMF2 Gene:
SUMF2 (sulfatase modifying factor 2) is a protein-coding gene. Diseases associated with SUMF2 include listeriosis, and campylobacteriosis. An important paralog of this gene is SUMF1.

UniProtKB/Swiss-Prot: SUMF2_HUMAN, Q8NBJ7
Function: Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases
to their active form. Inhibits the activation of sulfatases by SUMF1

Gene Wiki entry for SUMF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SUMF2 gene promoter:
         AREB6   GR   CREB   p53   deltaCREB   SEF-1 (1)   GR-alpha   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUMF2 promoter sequence
   Search Chromatin IP Primers for SUMF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SUMF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.1   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7q11.1

SUMF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUMF2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P056144:  view genomic region     (about GC identifiers)

Start:
56,131,695 bp from pter      End:
56,148,365 bp from pter
Size:
16,671 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 56,136,164-56,152,612     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SUMF2_HUMAN, Q8NBJ7 (See protein sequence)
Recommended Name: Sulfatase-modifying factor 2 precursor  
Size: 301 amino acids; 33843 Da
Subunit: Homodimer and heterodimer with SUMF1
Sequence caution: Sequence=AAH00224.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAB43247.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAB43247.1;
Type=Frameshift; Positions=150, 187;
1 PDB 3D structure from and Proteopedia for SUMF2:
1Y4J (3D)    
Secondary accessions: B4DU41 B4DWQ0 Q14DW5 Q53ZE3 Q96BH2 Q9BRN3 Q9BWI1 Q9Y405
Alternative splicing: 5 isoforms:  Q8NBJ7-1   Q8NBJ7-2   Q8NBJ7-3   Q8NBJ7-5   Q8NBJ7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SUMF2: NX_Q8NBJ7

Explore proteomics data for SUMF2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn191
  • Modification sites at PhosphoSitePlus

  • See SUMF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001035934.2  NP_001035935.2  NP_001123541.1  NP_001139805.1  NP_056226.2  

    ENSEMBL proteins: 
     ENSP00000378824   ENSP00000400922   ENSP00000378823   ENSP00000414434   ENSP00000341938  
     ENSP00000415322   ENSP00000407954   ENSP00000415989   ENSP00000406445   ENSP00000407832  
     ENSP00000393423   ENSP00000395554   ENSP00000410796   ENSP00000275607  
    Reactome Protein details: Q8NBJ7

    SUMF2 Human Recombinant Protein Products:

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    antibodies-online proteins for SUMF2 (4 products) 

     
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    antibodies-online antibodies for SUMF2 (14 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR005532 FGE_dom

    Graphical View of Domain Structure for InterPro Entry Q8NBJ7

    ProtoNet protein and cluster: Q8NBJ7

    UniProtKB/Swiss-Prot: SUMF2_HUMAN, Q8NBJ7
    Similarity: Belongs to the sulfatase-modifying factor family


    Find genes that share domains with SUMF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SUMF2_HUMAN, Q8NBJ7
    Function: Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases
    to their active form. Inhibits the activation of sulfatases by SUMF1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with SUMF2           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Sumf2 (no phenotypes)

    Find genes that share phenotypes with SUMF2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SUMF2

    miRNA
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    miRTarBase miRNAs that target SUMF2:
    hsa-mir-148b-3p (MIRT019274), hsa-mir-9-5p (MIRT021342)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SUMF2_HUMAN, Q8NBJ7: Endoplasmic reticulum lumen
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2
    golgi apparatus2
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005788endoplasmic reticulum lumen TAS--

    Find genes that share ontologies with SUMF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SUMF2 About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Glycosphingolipid metabolism0.56
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3PTM- gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM- gamma carboxylation, hypusine formation and arylsulfatase activation0.31
    The activation of arylsulfatases0.00
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30


    Find genes that share SuperPaths with SUMF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SUMF2
        Glycosphingolipid metabolism
    The activation of arylsulfatases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SUMF2
    Interactions:

        GeneGlobe Interaction Network for SUMF2

    4 Interacting proteins for SUMF2 (Q8NBJ72, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBXW7Q969H02, 3MINT-64983 I2D: score=5 
    ZFYVE9O954052, 3MINT-62042 I2D: score=3 
    H2AFXP161043I2D: score=2 
    CACNA1AO005553I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with SUMF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SUMF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SUMF2 gene (7 alternative transcripts): 
    NM_001042469.1  NM_001042470.1  NM_001130069.2  NM_001146333.1  NM_015411.2  NM_001042468.1  NM_001130070.1  

    Unigene Cluster for SUMF2:

    Sulfatase modifying factor 2
    Hs.279696  [show with all ESTs]
    Unigene Representative Sequence: CR936757
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000395436 ENST00000434526(uc011kcw.2 uc003trt.3 uc003trv.3 uc011kcy.2 uc011kcz.2 uc003trx.3 uc011kda.2 uc011kcx.2)
    ENST00000395435 ENST00000413952 ENST00000342190 ENST00000452216 ENST00000436782
    ENST00000437307 ENST00000413756 ENST00000483327 ENST00000423763 ENST00000498777
    ENST00000438133 ENST00000447501(uc011kcv.2) ENST00000451338 ENST00000529457
    ENST00000461912 ENST00000531229
    miRNA
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    Additional mRNA sequence: 

    AF075046.1 AK075477.1 AK297042.1 AK297793.1 AK298605.1 AK300488.1 AK301627.1 AY323911.1 
    AY359103.1 BC006159.1 BC015600.2 BC084539.1 BC111092.1 CR936749.1 CR936757.1 

    Selected DOTS entries (see all 44):

    DT.456309  DT.121122412  DT.95155302  DT.100798368  DT.100798365  DT.100798366  DT.100757357  DT.99965394 
    DT.121122235  DT.121122521  DT.121122478  DT.121122258  DT.100798363  DT.456310  DT.75150590  DT.100798356 
    DT.101963614  DT.121122428  DT.91756747  DT.121122262  DT.121122388  DT.121122467  DT.100027741  DT.95155300 

    Selected AceView cDNA sequences (see all 1112):

    N31527 AI498070 BU168894 CB160938 N67092 BU161330 BU162468 AI493047 
    BQ425583 BM829985 CB132352 CN479008 BI195723 BG164158 BU507016 CA423216 
    BE263560 AW411253 AA970264 BX361691 AA494536 BM800012 CN483288 AA554463 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SUMF2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
    SP1:                                      -           -           -     -     -                 -                 -                                       
    SP2:                                      -           -     -     -     -     -                 -                 -                                       
    SP3:                                      -     -     -           -     -     -                 -                 -                                       
    SP4:                                -     -     -     -     -     -     -     -                 -                 -                                       
    SP5:                                      -           -                                                                                                   


    ECgene alternative splicing isoforms for SUMF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SUMF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCAATAA
    SUMF2 Expression
    About this image


    SUMF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Brain (Nervous System)
             Lateral Ventricle
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    SUMF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SUMF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279696

    UniProtKB/Swiss-Prot: SUMF2_HUMAN, Q8NBJ7
    Tissue specificity: Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest
    levels in kidney, liver and placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SUMF2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sumf21 , 5 sulfatase modifying factor 21, 5 83.04(n)1
    84.7(a)1
      5 (68.26 cM)5
    679021  NM_026445.21  NP_080721.11 
     1298525115 
    chicken
    (Gallus gallus)
    Aves SUMF21 sulfatase modifying factor 2 74.14(n)
    76.84(a)
      417542  XM_415788.4  XP_415788.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.152352 Xenopus laevis transcribed sequence with weak similarity more 72.95(n)    BX848835.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.182072 Transcribed sequence with weak similarity to protein more 77.15(n)    BM572186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70496
    --
    29(a)
    1 → many
    3L(175112-176228)


    ENSEMBL Gene Tree for SUMF2 (if available)
    TreeFam Gene Tree for SUMF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SUMF2 gene
    SUMF12  
    5 SIMAP similar genes for SUMF2 using alignment to 14 protein entries:     SUMF2_HUMAN (see all proteins):
    DKFZP566I1024    GNPTAB    SERF1B    SUMF1    ECD

    Find genes that share paralogs with SUMF2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SUMF2
    PGOHUM00000260353 PGOHUM00000260359


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SUMF2 (see all 346)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389989431,2
    --56132321(+) CAGCAC/GTTTGG 5 -- int10--------
    rs1431233841,2
    --56132398(+) GTCTCC/TACAAA 5 -- int10--------
    rs132475581,2
    C,F--56132648(+) tgggaA/Ggccga 5 -- int13Minor allele frequency- G:0.33NA 6
    rs747863121,2
    C--56132675(+) GGTCAA/GGAAAT 5 -- int10--------
    rs125357491,2
    C,F,H--56132741(+) ttagcC/Tgggcg 5 -- int12Minor allele frequency- T:0.50NA 4
    rs1385100971,2
    --56132834(+) TGAGCA/GGAGAT 5 -- int10--------
    rs1874750321,2
    --56132871(+) ACAGCC/GAGACT 5 -- int10--------
    rs1932972051,2
    --56132949(+) CACGTA/CCTCGG 5 -- int10--------
    rs341548241,2
    C,F,H--56132957(+) CGGCCA/GGCTTA 5 -- int16Minor allele frequency- G:0.15NS NA EA 494
    rs1162346701,2
    F--56133011(+) ACACTC/TCCCCT 5 -- int11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for SUMF2 (56131695 - 56148365 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SUMF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734447CNV Deletion23290073
    esv2734448CNV Deletion23290073
    dgv1201e199CNV Deletion23128226
    esv28230CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SUMF2
    DNA2.0 Custom Variant and Variant Library Synthesis for SUMF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607940    OMIM disorders: --

    3 diseases for SUMF2:    
    About MalaCards
    listeriosis    campylobacteriosis    impetigo

    12 diseases from the University of Copenhagen DISEASES database for SUMF2:
    Mucoepidermoid carcinoma     Diarrhea     Listeriosis     Legionellosis
    Gastroenteritis     Impetigo     Shigellosis     Pneumonia
    Campylobacteriosis     Mastitis     Cystic fibrosis     Meningitis

    Find genes that share disorders with SUMF2           About GenesLikeMe


    Export disorders for SUMF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SUMF2 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with SUMF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases. (PubMed id 12757706)1, 2, 3 Cosma M.P.... Ballabio A. (Cell 2003)
    2. Sulphatase activities are regulated by the interaction of sulphatase- modifying factor 1 with SUMF2. (PubMed id 15962010)1, 2, 9 Zito E.... Cosma M.P. (EMBO Rep. 2005)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. Expression, localization, structural, and functional characterization of pFGE, the paralog of the Calpha-formylglycine-generating enzyme. (PubMed id 15708861)1, 2 Mariappan M.... von Figura K. (J. Biol. Chem. 2005)
    5. Crystal structure of human pFGE, the paralog of the Calpha- formylglycine-generating enzyme. (PubMed id 15687489)1, 2 Dickmanns A.... Ficner R. (J. Biol. Chem. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. SUMF2 interacts with interleukin-13 and inhibits interleukin-13 secretion in bronchial smooth muscle cells. (PubMed id 19739097)1, 9 Liang H....Liu F. (J. Cell. Biochem. 2009)
    10. The human SUMF1 gene, required for posttranslational sulfatase modification, defines a new gene family which is conserved from pro- to eukaryotes. (PubMed id 14563551)1, 9 Landgrebe J....von Figura K. (Gene 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25870 HGNC: 20415 AceView: CCT6AandSUMF2 Ensembl:ENSG00000129103 euGenes: HUgn25870
    ECgene: SUMF2 H-InvDB: SUMF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SUMF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SUMF2 gene:
    Search GeneIP for patents involving SUMF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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