Aliases for SUMF2 Gene
External Ids for SUMF2 Gene
Previous GeneCards Identifiers for SUMF2 Gene
The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for SUMF2 Gene
SUMF2 (Sulfatase Modifying Factor 2) is a Protein Coding gene. Diseases associated with SUMF2 include listeriosis and campylobacteriosis. Among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and PTM- gamma carboxylation, hypusine formation and arylsulfatase activation. An important paralog of this gene is SUMF1.
UniProtKB/Swiss-Prot for SUMF2 Gene
Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.