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Aliases for SUMF2 Gene

Aliases for SUMF2 Gene

  • Sulfatase Modifying Factor 2 2 3
  • C-Alpha-Formylglycine-Generating Enzyme 2 3 4
  • Paralog Of The Formylglycine-Generating Enzyme 3
  • C-Alpha-Formyglycine-Generating Enzyme 2 3
  • Sulfatase-Modifying Factor 2 3
  • PFGE 3

External Ids for SUMF2 Gene

Previous GeneCards Identifiers for SUMF2 Gene

  • GC07P055839
  • GC07P055873
  • GC07P055906
  • GC07P056099
  • GC07P056132
  • GC07P055946
  • GC07P056135
  • GC07P056139

Summaries for SUMF2 Gene

Entrez Gene Summary for SUMF2 Gene

  • The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for SUMF2 Gene

SUMF2 (Sulfatase Modifying Factor 2) is a Protein Coding gene. Diseases associated with SUMF2 include listeriosis and campylobacteriosis. Among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and PTM- gamma carboxylation, hypusine formation and arylsulfatase activation. An important paralog of this gene is SUMF1.

UniProtKB/Swiss-Prot for SUMF2 Gene

  • Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.

Gene Wiki entry for SUMF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUMF2 Gene

Genomics for SUMF2 Gene

Regulatory Elements for SUMF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SUMF2 Gene

Start:
56,064,002 bp from pter
End:
56,080,672 bp from pter
Size:
16,671 bases
Orientation:
Plus strand

Genomic View for SUMF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUMF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUMF2 Gene

Proteins for SUMF2 Gene

  • Protein details for SUMF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBJ7-SUMF2_HUMAN
    Recommended name:
    Sulfatase-modifying factor 2
    Protein Accession:
    Q8NBJ7
    Secondary Accessions:
    • B4DU41
    • B4DWQ0
    • Q14DW5
    • Q53ZE3
    • Q96BH2
    • Q9BRN3
    • Q9BWI1
    • Q9Y405

    Protein attributes for SUMF2 Gene

    Size:
    301 amino acids
    Molecular mass:
    33843 Da
    Quaternary structure:
    • Homodimer and heterodimer with SUMF1.
    SequenceCaution:
    • Sequence=AAH00224.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB43247.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB43247.1; Type=Frameshift; Positions=150, 187; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUMF2 Gene

    Alternative splice isoforms for SUMF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUMF2 Gene

Proteomics data for SUMF2 Gene at MOPED

Post-translational modifications for SUMF2 Gene

  • Glycosylation at Asn191
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SUMF2 (Sulfatase Modifying Factor 2/SUMF2)

No data available for DME Specific Peptides for SUMF2 Gene

Domains for SUMF2 Gene

Protein Domains for SUMF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SUMF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBJ7

UniProtKB/Swiss-Prot:

SUMF2_HUMAN :
  • Q8NBJ7
Family:
  • Belongs to the sulfatase-modifying factor family.
genes like me logo Genes that share domains with SUMF2: view

No data available for Gene Families for SUMF2 Gene

Function for SUMF2 Gene

Molecular function for SUMF2 Gene

UniProtKB/Swiss-Prot Function:
Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.

Gene Ontology (GO) - Molecular Function for SUMF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SUMF2: view

Animal Model Products

miRNA for SUMF2 Gene

miRTarBase miRNAs that target SUMF2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUMF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SUMF2 Gene

Localization for SUMF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUMF2 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUMF2 Gene COMPARTMENTS Subcellular localization image for SUMF2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
golgi apparatus 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SUMF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with SUMF2: view

Pathways for SUMF2 Gene

genes like me logo Genes that share pathways with SUMF2: view

Interacting Proteins for SUMF2 Gene

Gene Ontology (GO) - Biological Process for SUMF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SUMF2: view

Transcripts for SUMF2 Gene

Unigene Clusters for SUMF2 Gene

Sulfatase modifying factor 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUMF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUMF2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - -
SP6: - - - - - -
SP7: - -
SP8: -
SP9: -
SP10:
SP11:

Relevant External Links for SUMF2 Gene

GeneLoc Exon Structure for
SUMF2
ECgene alternative splicing isoforms for
SUMF2

Expression for SUMF2 Gene

mRNA expression in normal human tissues for SUMF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SUMF2 Gene

This gene is overexpressed in Testis (10.3) and Oral epithelium (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SUMF2 Gene

SOURCE GeneReport for Unigene cluster for SUMF2 Gene Hs.279696

mRNA Expression by UniProt/SwissProt for SUMF2 Gene

Q8NBJ7-SUMF2_HUMAN
Tissue specificity: Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in kidney, liver and placenta.
genes like me logo Genes that share expressions with SUMF2: view

Expression partners for SUMF2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SUMF2 Gene

Orthologs for SUMF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUMF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SUMF2 35
  • 88.7 (n)
  • 89.49 (a)
SUMF2 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUMF2 35
  • 87.51 (n)
  • 87.99 (a)
SUMF2 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sumf2 35
  • 83.04 (n)
  • 84.7 (a)
Sumf2 16
Sumf2 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SUMF2 35
  • 99.37 (n)
  • 98.44 (a)
SUMF2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sumf2 35
  • 84.18 (n)
  • 85.51 (a)
oppossum
(Monodelphis domestica)
Mammalia SUMF2 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUMF2 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUMF2 35
  • 74.14 (n)
  • 76.84 (a)
SUMF2 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20228 35
sumf2 35
  • 69.1 (n)
  • 72.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15235 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18207 35
sumf2 35
  • 69.82 (n)
  • 71.21 (a)
sumf2 36
  • 47 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10189 35
fruit fly
(Drosophila melanogaster)
Insecta CG7049 36
  • 29 (a)
OneToMany
Species with no ortholog for SUMF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUMF2 Gene

ENSEMBL:
Gene Tree for SUMF2 (if available)
TreeFam:
Gene Tree for SUMF2 (if available)

Paralogs for SUMF2 Gene

Paralogs for SUMF2 Gene

Pseudogenes.org Pseudogenes for SUMF2 Gene

genes like me logo Genes that share paralogs with SUMF2: view

Variants for SUMF2 Gene

Sequence variations from dbSNP and Humsavar for SUMF2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3735066 -- 56,078,311(+) GGGTA(A/G)GCGGG intron-variant
rs4245575 - 56,068,567(+) GGTGA(A/C)GGGCC intron-variant, utr-variant-5-prime, nc-transcript-variant
rs4345511 -- 56,067,765(+) GTGCA(C/T)ACTTG intron-variant
rs4585698 -- 56,066,572(+) CTTCC(C/G)GAGTA intron-variant
rs4948104 -- 56,074,826(+) GGCGC(A/G)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUMF2 Gene

Variant ID Type Subtype PubMed ID
esv28230 CNV Gain+Loss 19812545
esv2734447 CNV Deletion 23290073
dgv1201e199 CNV Deletion 23128226
esv2734448 CNV Deletion 23290073

Relevant External Links for SUMF2 Gene

HapMap Linkage Disequilibrium report
SUMF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUMF2 Gene

Disorders for SUMF2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SUMF2 Gene in MalaCards »

(4) Diseases for SUMF2 Gene including...

genes like me logo Genes that share disorders with SUMF2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for SUMF2 Gene

Publications for SUMF2 Gene

  1. Sulphatase activities are regulated by the interaction of sulphatase- modifying factor 1 with SUMF2. (PMID: 15962010) Zito E. … Cosma M.P. (EMBO Rep. 2005) 3 4 23
  2. The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases. (PMID: 12757706) Cosma M.P. … Ballabio A. (Cell 2003) 2 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. SUMF2 interacts with interleukin-13 and inhibits interleukin-13 secretion in bronchial smooth muscle cells. (PMID: 19739097) Liang H. … Liu F. (J. Cell. Biochem. 2009) 3 23

Products for SUMF2 Gene

Sources for SUMF2 Gene

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