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Aliases for SULT6B1 Gene

Aliases for SULT6B1 Gene

  • Sulfotransferase Family 6B Member 1 2 3 5
  • Sulfotransferase Family, Cytosolic, 6B, Member 1 2 3
  • Thyroxine Sulfotransferase 3 4
  • ST6B1 3 4
  • Sulfotransferase SULT6B1 3
  • Sulfotransferase 6B1 3
  • EC 2.8.2.n2 4

External Ids for SULT6B1 Gene

Previous GeneCards Identifiers for SULT6B1 Gene

  • GC02M037307
  • GC02M037248
  • GC02M037394

Summaries for SULT6B1 Gene

GeneCards Summary for SULT6B1 Gene

SULT6B1 (Sulfotransferase Family 6B Member 1) is a Protein Coding gene. Among its related pathways are Sulfation Biotransformation Reaction and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT4A1.

UniProtKB/Swiss-Prot for SULT6B1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity).

Additional gene information for SULT6B1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT6B1 Gene

Genomics for SULT6B1 Gene

Regulatory Elements for SULT6B1 Gene

Enhancers for SULT6B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H037375 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -180.9 -180935 3 PKNOX1 ARNT FEZF1 ZNF2 ZNF207 ATF7 RUNX3 SP3 JUNB REST RPL31P16 SULT6B1 LOC100422559 LOC101929542 PRKD3 RNU6-939P CDC42EP3 RMDN2 CYP1B1 QPCT
GH02H038095 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -900.7 -900709 4 PKNOX1 ARNT FEZF1 ZBTB7B GLIS2 FOS KLF7 RUNX3 SP3 ZC3H11A CYP1B1 CYP1B1-AS1 LINC01883 TTC39DP ENSG00000225284 SULT6B1 RPL31P16 DHX57 ARHGEF33 RMDN2-AS1
GH02H037154 1 ENCODE 10.9 +40.1 40078 3 HDGF PKNOX1 ARID4B SIN3A DMAP1 BRCA1 ZNF766 SP3 SP5 REST NDUFAF7 EIF2AK2 RPL31P16 CEBPZOS SULT6B1 CEBPZ ENSG00000224891
GH02H037181 1.2 Ensembl ENCODE dbSUPER 6.6 +14.7 14716 1 HDAC1 JUN ZBTB40 FOSL1 GATA3 ZNF316 GATA2 NFE2 MAFK SMARCE1 NDUFAF7 EIF2AK2 CEBPZOS CEBPZ RNU6-939P SULT6B1 PRKD3 RPL31P16
GH02H037149 0.6 ENCODE 10.9 +46.7 46662 1 ATF1 NFYC FEZF1 ZNF843 GABPA PRDM6 HMBOX1 MAFK ZNF18 RPL31P16 CEBPZOS SULT6B1 NDUFAF7 CEBPZ EIF2AK2 STRN ENSG00000224891
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SULT6B1 on UCSC Golden Path with GeneCards custom track

Promoters for SULT6B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000115324 -203 1600 ATF1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF766 ATF7 RUNX3 SP3

Genomic Location for SULT6B1 Gene

Chromosome:
2
Start:
37,167,820 bp from pter
End:
37,196,598 bp from pter
Size:
28,779 bases
Orientation:
Minus strand

Genomic View for SULT6B1 Gene

Genes around SULT6B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT6B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT6B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT6B1 Gene

Proteins for SULT6B1 Gene

  • Protein details for SULT6B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IMI4-ST6B1_HUMAN
    Recommended name:
    Sulfotransferase 6B1
    Protein Accession:
    Q6IMI4
    Secondary Accessions:
    • B2RTS7

    Protein attributes for SULT6B1 Gene

    Size:
    303 amino acids
    Molecular mass:
    34919 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI40798.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=DAA01772.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SULT6B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT6B1 Gene

Post-translational modifications for SULT6B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT6B1 Gene

No data available for DME Specific Peptides for SULT6B1 Gene

Domains & Families for SULT6B1 Gene

Gene Families for SULT6B1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SULT6B1 Gene

Suggested Antigen Peptide Sequences for SULT6B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IMI4

UniProtKB/Swiss-Prot:

ST6B1_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT6B1: view

Function for SULT6B1 Gene

Molecular function for SULT6B1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + thyroxine = adenosine 3,5-bisphosphate + thyroxine-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity).

Enzyme Numbers (IUBMB) for SULT6B1 Gene

Phenotypes From GWAS Catalog for SULT6B1 Gene

Gene Ontology (GO) - Molecular Function for SULT6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity TAS --
GO:0008146 sulfotransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SULT6B1: view

Phenotypes for SULT6B1 Gene

GenomeRNAi human phenotypes for SULT6B1:
genes like me logo Genes that share phenotypes with SULT6B1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SULT6B1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SULT6B1 Gene

Localization for SULT6B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT6B1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT6B1 gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for SULT6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT6B1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SULT6B1 Gene

Pathways & Interactions for SULT6B1 Gene

genes like me logo Genes that share pathways with SULT6B1: view

Pathways by source for SULT6B1 Gene

Interacting Proteins for SULT6B1 Gene

Gene Ontology (GO) - Biological Process for SULT6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
genes like me logo Genes that share ontologies with SULT6B1: view

No data available for SIGNOR curated interactions for SULT6B1 Gene

Drugs & Compounds for SULT6B1 Gene

(1) Drugs for SULT6B1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Levothyroxine Approved Pharma 0

(2) Additional Compounds for SULT6B1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with SULT6B1: view

Transcripts for SULT6B1 Gene

mRNA/cDNA for SULT6B1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT6B1 Gene

Sulfotransferase family, cytosolic, 6B, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SULT6B1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SULT6B1 Gene

No ASD Table

Relevant External Links for SULT6B1 Gene

GeneLoc Exon Structure for
SULT6B1
ECgene alternative splicing isoforms for
SULT6B1

Expression for SULT6B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SULT6B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT6B1 Gene

This gene is overexpressed in Testis (x48.0).

Protein differential expression in normal tissues from HIPED for SULT6B1 Gene

This gene is overexpressed in Testis (59.4) and Platelet (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SULT6B1 Gene



Protein tissue co-expression partners for SULT6B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SULT6B1 Gene:

SULT6B1

SOURCE GeneReport for Unigene cluster for SULT6B1 Gene:

Hs.631892

mRNA Expression by UniProt/SwissProt for SULT6B1 Gene:

Q6IMI4-ST6B1_HUMAN
Tissue specificity: Specifically expressed in kidney and testis.
genes like me logo Genes that share expression patterns with SULT6B1: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT6B1 Gene

Orthologs for SULT6B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SULT6B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT6B1 33 34
  • 98.87 (n)
cow
(Bos Taurus)
Mammalia SULT6B1 33 34
  • 89.77 (n)
dog
(Canis familiaris)
Mammalia SULT6B1 33 34
  • 89.56 (n)
rat
(Rattus norvegicus)
Mammalia Sult6b1 33
  • 85.17 (n)
mouse
(Mus musculus)
Mammalia Sult6b1 33 16 34
  • 84.66 (n)
oppossum
(Monodelphis domestica)
Mammalia SULT6B1 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 25 (a)
OneToMany
chicken
(Gallus gallus)
Aves SULT6B1 34 33
  • 72.2 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
OneToMany
-- 34
  • 45 (a)
OneToMany
-- 34
  • 45 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135365 33
  • 62.26 (n)
zebrafish
(Danio rerio)
Actinopterygii sult6b1 33 34
  • 57.58 (n)
Species where no ortholog for SULT6B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT6B1 Gene

ENSEMBL:
Gene Tree for SULT6B1 (if available)
TreeFam:
Gene Tree for SULT6B1 (if available)

Paralogs for SULT6B1 Gene

Paralogs for SULT6B1 Gene

(13) SIMAP similar genes for SULT6B1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SULT6B1: view

Variants for SULT6B1 Gene

Sequence variations from dbSNP and Humsavar for SULT6B1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000110601 -- 37,167,997(+) GCACT(C/G)TTTGA reference, missense
rs1000342592 -- 37,186,942(+) TACTA(C/T)CATCC intron-variant
rs1000427069 -- 37,190,151(+) TTTAG(A/C)CTATA upstream-variant-2KB
rs1000437178 -- 37,187,151(+) TAGCA(C/T)TTCTA intron-variant
rs1000565817 -- 37,168,228(+) TCTGT(A/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULT6B1 Gene

Variant ID Type Subtype PubMed ID
nsv2683 CNV insertion 18451855

Variation tolerance for SULT6B1 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.33; 90.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULT6B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT6B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT6B1 Gene

Disorders for SULT6B1 Gene

Relevant External Links for SULT6B1

Human Genome Epidemiology (HuGE) Navigator
SULT6B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SULT6B1

No disorders were found for SULT6B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SULT6B1 Gene

Publications for SULT6B1 Gene

  1. Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. (PMID: 14676822) Freimuth RR … Weinshilboum RM (The pharmacogenomics journal 2004) 2 3 4 60
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  3. Human Sulfotransferases Enhance the Cytotoxicity of Tolvaptan. (PMID: 26660633) Fang JL … Beland FA (Toxicological sciences : an official journal of the Society of Toxicology 2016) 3 60
  4. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S … Sullivan PF (Nature genetics 2013) 3 60
  5. Genome-wide association study of schizophrenia in a Japanese population. (PMID: 20832056) Ikeda M … Iwata N (Biological psychiatry 2011) 3 60

Products for SULT6B1 Gene

Sources for SULT6B1 Gene

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