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Aliases for SULT6B1 Gene

Aliases for SULT6B1 Gene

  • Sulfotransferase Family, Cytosolic, 6B, Member 1 2 3
  • Thyroxine Sulfotransferase 3 4
  • ST6B1 3 4
  • Sulfotransferase SULT6B1 3
  • Sulfotransferase 6B1 3
  • EC 2.8.2.n2 4

External Ids for SULT6B1 Gene

Summaries for SULT6B1 Gene

GeneCards Summary for SULT6B1 Gene

SULT6B1 (Sulfotransferase Family, Cytosolic, 6B, Member 1) is a Protein Coding gene. Among its related pathways are Biological oxidations and Sulfation Biotransformation Reaction. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT6B1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT6B1 Gene

Genomics for SULT6B1 Gene

Genomic Location for SULT6B1 Gene

Start:
37,167,820 bp from pter
End:
37,196,598 bp from pter
Size:
28,779 bases
Orientation:
Minus strand

Genomic View for SULT6B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SULT6B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT6B1 Gene

Regulatory Elements for SULT6B1 Gene

Proteins for SULT6B1 Gene

  • Protein details for SULT6B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IMI4-ST6B1_HUMAN
    Recommended name:
    Sulfotransferase 6B1
    Protein Accession:
    Q6IMI4
    Secondary Accessions:
    • B2RTS7

    Protein attributes for SULT6B1 Gene

    Size:
    303 amino acids
    Molecular mass:
    34919 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI40798.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=DAA01772.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SULT6B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT6B1 Gene

Proteomics data for SULT6B1 Gene at MOPED

Post-translational modifications for SULT6B1 Gene

No Post-translational modifications

Other Protein References for SULT6B1 Gene

No data available for DME Specific Peptides for SULT6B1 Gene

Domains for SULT6B1 Gene

Gene Families for SULT6B1 Gene

HGNC:
  • SULT :Sulfotransferases, cytosolic

Protein Domains for SULT6B1 Gene

UniProtKB/Swiss-Prot:

ST6B1_HUMAN
Family:
  • Belongs to the sulfotransferase 1 family.:
    • Q6IMI4
genes like me logo Genes that share domains with SULT6B1: view

Function for SULT6B1 Gene

Molecular function for SULT6B1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + thyroxine = adenosine 3,5-bisphosphate + thyroxine-sulfate
UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity).

Enzyme Numbers (IUBMB) for SULT6B1 Gene

Gene Ontology (GO) - Molecular Function for SULT6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with SULT6B1: view

Phenotypes for SULT6B1 Gene

GenomeRNAi human phenotypes for SULT6B1:
genes like me logo Genes that share phenotypes with SULT6B1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SULT6B1 Gene

Localization for SULT6B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT6B1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT6B1 Gene COMPARTMENTS Subcellular localization image for SULT6B1 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for SULT6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SULT6B1: view

Pathways for SULT6B1 Gene

genes like me logo Genes that share pathways with SULT6B1: view

Pathways by source for SULT6B1 Gene

Interacting Proteins for SULT6B1 Gene

Gene Ontology (GO) - Biological Process for SULT6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with SULT6B1: view

Transcripts for SULT6B1 Gene

mRNA/cDNA for SULT6B1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT6B1 Gene

Sulfotransferase family, cytosolic, 6B, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT6B1 Gene

No ASD Table

Relevant External Links for SULT6B1 Gene

GeneLoc Exon Structure for
SULT6B1
ECgene alternative splicing isoforms for
SULT6B1

Expression for SULT6B1 Gene

mRNA expression in normal human tissues for SULT6B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT6B1 Gene

This gene is overexpressed in Testis (48.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SULT6B1 Gene

SOURCE GeneReport for Unigene cluster for SULT6B1 Gene Hs.631892

mRNA Expression by UniProt/SwissProt for SULT6B1 Gene

Q6IMI4-ST6B1_HUMAN
Tissue specificity: Specifically expressed in kidney and testis.
genes like me logo Genes that share expressions with SULT6B1: view

Orthologs for SULT6B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SULT6B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT6B1 36
  • 98.87 (n)
  • 97.74 (a)
SULT6B1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SULT6B1 36
  • 89.77 (n)
  • 87.5 (a)
SULT6B1 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SULT6B1 36
  • 89.56 (n)
  • 89.81 (a)
SULT6B1 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sult6b1 36
  • 84.66 (n)
  • 85.55 (a)
Sult6b1 16
Sult6b1 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SULT6B1 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 25 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sult6b1 36
  • 85.17 (n)
  • 83.65 (a)
chicken
(Gallus gallus)
Aves SULT6B1 36
  • 72.2 (n)
  • 64.91 (a)
SULT6B1 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 45 (a)
OneToMany
-- 37
  • 41 (a)
OneToMany
-- 37
  • 44 (a)
OneToMany
-- 37
  • 45 (a)
OneToMany
-- 37
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135365 36
  • 62.26 (n)
  • 53.21 (a)
zebrafish
(Danio rerio)
Actinopterygii sult6b1 36
  • 57.58 (n)
  • 50 (a)
sult6b1 37
  • 44 (a)
OneToOne
Species with no ortholog for SULT6B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT6B1 Gene

ENSEMBL:
Gene Tree for SULT6B1 (if available)
TreeFam:
Gene Tree for SULT6B1 (if available)

Paralogs for SULT6B1 Gene

Selected SIMAP similar genes for SULT6B1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SULT6B1: view

Variants for SULT6B1 Gene

Sequence variations from dbSNP and Humsavar for SULT6B1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs881415 -- 37,193,920(-) AGAAA(C/T)TTTTA intron-variant
rs1017160 -- 37,191,553(-) tgcca(A/C)atgtg intron-variant
rs2111629 -- 37,179,893(-) AGGTC(A/G)TACTC intron-variant
rs2111630 -- 37,179,664(-) GGACA(C/T)GATGA intron-variant
rs2373190 -- 37,179,019(+) AGTGG(C/T)GCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULT6B1 Gene

Variant ID Type Subtype PubMed ID
nsv2683 CNV Insertion 18451855

Relevant External Links for SULT6B1 Gene

HapMap Linkage Disequilibrium report
SULT6B1

Disorders for SULT6B1 Gene

Relevant External Links for SULT6B1

Human Genome Epidemiology (HuGE) Navigator
SULT6B1
genes like me logo Genes that share disorders with SULT6B1: view

No data available for UniProtKB/Swiss-Prot for SULT6B1 Gene

Publications for SULT6B1 Gene

  1. Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. (PMID: 14676822) Freimuth R.R. … Weinshilboum R.M. (Pharmacogenomics J. 2004) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Structural and chemical profiling of the human cytosolic sulfotransferases. (PMID: 17425406) Allali-Hassani A. … Arrowsmith C.H. (PLoS Biol. 2007) 3
  4. Genome-wide association study of schizophrenia in a Japanese population. (PMID: 20832056) Ikeda M. … Iwata N. (Biol. Psychiatry 2011) 3
  5. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3

Products for SULT6B1 Gene

Sources for SULT6B1 Gene

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