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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SULT6B1 Gene

protein-coding   GIFtS: 45
GCID: GC02M037394

Sulfotransferase Family, Cytosolic, 6B, Member 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sulfotransferase Family, Cytosolic, 6B, Member 11 2
Thyroxine Sulfotransferase2 3
ST6B12 3
Sulfotransferase 6B12
Sulfotransferase SULT6B12
EC 2.8.2.n23

External Ids:    HGNC: 334331   Entrez Gene: 3913652   Ensembl: ENSG000001380687   UniProtKB: Q6IMI43   

Export aliases for SULT6B1 gene to outside databases

Previous GC identifers: GC02M037307 GC02M037248 GC02M037134


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SULT6B1 Gene: 
SULT6B1 (sulfotransferase family, cytosolic, 6B, member 1) is a protein-coding gene. Diseases associated with SULT6B1 include schizophrenia, and alcoholism, and among its related super-pathways are Cytosolic sulfonation of small molecules and Biological oxidations. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1C3.

UniProtKB/Swiss-Prot: ST6B1_HUMAN, Q6IMI4
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SULT6B1 gene promoter:
         USF1   Tal-1   Nkx5-1   HNF-1A   AREB6   POU2F1   HNF-1   POU2F1a   USF-1   Sox9   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SULT6B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULT6B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.2   Ensembl cytogenetic band:  2p22.2   HGNC cytogenetic band: 2p22.2

SULT6B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT6B1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M037394:  view genomic region     (about GC identifiers)

Start:
37,394,963 bp from pter      End:
37,423,741 bp from pter
Size:
28,779 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ST6B1_HUMAN, Q6IMI4 (See protein sequence)
Recommended Name: Sulfotransferase 6B1  
Size: 303 amino acids; 34919 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAI40798.1; Type=Erroneous initiation; Sequence=DAA01772.1; Type=Erroneous initiation;
Secondary accessions: B2RTS7
Alternative splicing: 2 isoforms:  Q6IMI4-1   Q6IMI4-2   

Explore the universe of human proteins at neXtProt for SULT6B1: NX_Q6IMI4

Explore proteomics data for SULT6B1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6IMI4

  • SULT6B1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SULT6B1 Protein Expression
    REFSEQ proteins: NP_001027549.1  
    ENSEMBL proteins: 
     ENSP00000384950   ENSP00000407014   ENSP00000416947   ENSP00000395999   ENSP00000444081  
     ENSP00000368444   ENSP00000260637  

    Human Recombinant Protein Products for SULT6B1: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SULT6B1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    SULT6B1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SULT: Sulfotransferases, cytosolic

    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry Q6IMI4

    ProtoNet protein and cluster: Q6IMI4

    1 Blocks protein domain: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST6B1_HUMAN, Q6IMI4
    Similarity: Belongs to the sulfotransferase 1 family


    SULT6B1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST6B1_HUMAN, Q6IMI4
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity)
    Catalytic activity: 3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-bisphosphate + thyroxine-sulfate

         Enzyme Number (IUBMB): EC 2.8.2.n21

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity IEA--
         
    SULT6B1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SULT6B1:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SULT6B1 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT6B1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SULT6B1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytosolic sulfonation of small molecules
    Sulfation Biotransformation Reaction0.52
    2Biological oxidations
    metapathway biotransformation0.41


    2 BioSystems Pathways for SULT6B1
        Sulfation Biotransformation Reaction
    metapathway biotransformation


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SULT6B1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SULT6B1 (ST6B1)

    Search CenterWatch for drugs/clinical trials and news about SULT6B1 / ST6B1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SULT6B1 gene: 
    NM_001032377.1  

    Unigene Cluster for SULT6B1:

    Sulfotransferase family, cytosolic, 6B, member 1
    Hs.631892  [show with all ESTs]
    Unigene Representative Sequence: NM_001032377
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407963(uc010fag.2) ENST00000420611 ENST00000416345(uc002rpv.3 uc010fae.2 uc010faf.2)
    ENST00000433192(uc002rpw.3) ENST00000535679 ENST00000379149 ENST00000260637(uc002rpu.3 uc010yni.2)

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SULT6B1:
    hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidSULT6B1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AY289770.1 AY289771.1 AY289772.1 AY289773.1 AY289774.1 AY289775.1 BC140797.1 BC144573.1 
    BC144574.1 

    2 DOTS entries:

    DT.102830092  DT.102830091 

    6 AceView cDNA sequences:

    AY289775 AY289773 AY289774 AY289772 AY289771 AY289770 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SULT6B1 expression in normal human tissues (normalized intensities)      SULT6B1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SULT6B1 Expression
    About this image


    SULT6B1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Inner Cell Mass (Early Embryonic Tissues)
             Sox17-GFP genetically modified stem cells

    See SULT6B1 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.631892

    UniProtKB/Swiss-Prot: ST6B1_HUMAN, Q6IMI4
    Tissue specificity: Specifically expressed in kidney and testis

        SABiosciences Expression via Pathway-Focused PCR Array including SULT6B1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT6B1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SULT6B1 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sult6b11 , 5 sulfotransferase family, cytosolic, 6B, member 11, 5 84.66(n)1
    85.55(a)1
      17 (49.60 cM)5
    736711  NM_001163625.11  NP_001157097.11 
     788848975 
    chicken
    (Gallus gallus)
    Aves SULT6B11 sulfotransferase family, cytosolic, 6B, member 1 72.35(n)
    65.15(a)
      421473  XM_419522.3  XP_419522.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 5)
    --
    47(a)
    45(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    1(232500184-232517568)
    1(224484238-224498318)
    zebrafish
    (Danio rerio)
    Actinopterygii sult6b11 sulfotransferase family, cytosolic, 6b, member 1 57.82(n)
    50.77(a)
      322462  NM_214686.1  NP_999851.1 


    ENSEMBL Gene Tree for SULT6B1 (if available)
    TreeFam Gene Tree for SULT6B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SULT6B1 gene
    SULT1C32  SULT4A12  SULT1B12  SULT1A22  SULT1C42  SULT1C22  SULT1E12  SULT2B12  
    SULT1A42  SULT2A12  SULT1A12  SULT1A32  
    13 SIMAP similar genes for SULT6B1 using alignment to 2 protein entries:     ST6B1_HUMAN (see all proteins):
    SULT1A2    SULT1C2    SULT1C4    SULT1E1    SULT1A1    SULT1B1
    SULT2A1    SULT2B1    ST1A5    SULT1A3    SULT1A4    SULT4A1
    SULT1C3

    SULT6B1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/721 SNPs in SULT6B1 are shown (see all 721)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1155263101,2
    F--37394490(+) TAAGTA/GGAAAT 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1158659371,2
    F--37394666(+) CCATAG/TTAAGA 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1477160141,2
    --37394771(+) TAGTAA/TCTCCT 1 -- ds50010--------
    rs101837041,2
    C,F--37394788(+) CTTACG/CTGAAC 1 -- ds50016Minor allele frequency- C:0.23WA NA EA 602
    rs1490639781,2
    --37394928(+) CATTAG/TTATTA 1 -- ds50010--------
    rs456303441,2
    F--37394978(-) TTAAA-/TCAATA 1 -- ut311Minor allele frequency- T:0.05--240
    rs1429614521,2
    C--37394980(+) ATTGT-/TTAA  
            
    TTATT
    1 -- ut310--------
    rs2003186771,2
    --37395075(+) GACTGA/GAATCA 1 -- ut310--------
    rs454953941,2,4
    C,F--37395103(+) CATACA/C/TTCAAC 3 K R M mis15CSA NA EU 6234
    rs1153605201,2
    C,F--37395105(+) TACTTC/TAACTT 2 L syn13Minor allele frequency- T:0.01WA NA EU 5991

    HapMap Linkage Disequilibrium report for SULT6B1 (37394963 - 37423741 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SULT6B1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2683CNV Insertion18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SULT6B1:    About MalaCards
    schizophrenia    alcoholism


    SULT6B1 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: SULT6B1 (1 document)

    Export disorders for SULT6B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SULT6B1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SULT6B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. (PubMed id 14676822)1, 2, 3 Freimuth R.R.... Weinshilboum R.M. (2004)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. Genome-Wide Association Study of Schizophrenia in a J apanese Population. (PubMed id 20832056)1 Ikeda M....Iwata N. (2010)
    4. Molecular cloning, expression and characterization of a novel mouse SULT6 cytosolic sulfotransferase. (PubMed id 19505954)2 Takahashi S.... Suiko M. (2009)
    5. Structural and chemical profiling of the human cytosolic sulfotransferases. (PubMed id 17425406)1 Allali-Hassani A....Arrowsmith C.H. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 391365 HGNC: 33433 AceView: LOC391365 Ensembl:ENSG00000138068 euGenes: HUgn391365
    ECgene: SULT6B1 H-InvDB: SULT6B1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SULT6B1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SULT6B1 gene:
    Search GeneIP for patents involving SULT6B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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