Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SULT6B1 Gene

Aliases for SULT6B1 Gene

  • Sulfotransferase Family 6B Member 1 2 3 5
  • Sulfotransferase Family, Cytosolic, 6B, Member 1 2 3
  • Thyroxine Sulfotransferase 3 4
  • ST6B1 3 4
  • Sulfotransferase SULT6B1 3
  • EC 2.8.2.n2 4

External Ids for SULT6B1 Gene

Previous GeneCards Identifiers for SULT6B1 Gene

  • GC02M037307
  • GC02M037248
  • GC02M037394

Summaries for SULT6B1 Gene

GeneCards Summary for SULT6B1 Gene

SULT6B1 (Sulfotransferase Family 6B Member 1) is a Protein Coding gene. Among its related pathways are Sulfation Biotransformation Reaction and Phase II conjugation. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT6B1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT6B1 Gene

Genomics for SULT6B1 Gene

Regulatory Elements for SULT6B1 Gene

Enhancers for SULT6B1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SULT6B1 on UCSC Golden Path with GeneCards custom track

Promoters for SULT6B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SULT6B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SULT6B1 Gene

37,167,820 bp from pter
37,196,598 bp from pter
28,779 bases
Minus strand

Genomic View for SULT6B1 Gene

Genes around SULT6B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT6B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT6B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT6B1 Gene

Proteins for SULT6B1 Gene

  • Protein details for SULT6B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sulfotransferase 6B1
    Protein Accession:
    Secondary Accessions:
    • B2RTS7

    Protein attributes for SULT6B1 Gene

    303 amino acids
    Molecular mass:
    34919 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI40798.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=DAA01772.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SULT6B1 Gene


neXtProt entry for SULT6B1 Gene

Proteomics data for SULT6B1 Gene at MOPED

Post-translational modifications for SULT6B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT6B1 Gene

No data available for DME Specific Peptides for SULT6B1 Gene

Domains & Families for SULT6B1 Gene

Gene Families for SULT6B1 Gene

Protein Domains for SULT6B1 Gene

Suggested Antigen Peptide Sequences for SULT6B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfotransferase 1 family.
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT6B1: view

Function for SULT6B1 Gene

Molecular function for SULT6B1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + thyroxine = adenosine 3,5-bisphosphate + thyroxine-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity).

Enzyme Numbers (IUBMB) for SULT6B1 Gene

Phenotypes for SULT6B1 Gene

GenomeRNAi human phenotypes for SULT6B1:
genes like me logo Genes that share phenotypes with SULT6B1: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SULT6B1 Gene

Localization for SULT6B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT6B1 Gene


Subcellular locations from

Jensen Localization Image for SULT6B1 Gene COMPARTMENTS Subcellular localization image for SULT6B1 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for SULT6B1 Gene

Pathways & Interactions for SULT6B1 Gene

genes like me logo Genes that share pathways with SULT6B1: view

Pathways by source for SULT6B1 Gene

Interacting Proteins for SULT6B1 Gene

Gene Ontology (GO) - Biological Process for SULT6B1 Gene


No data available for SIGNOR curated interactions for SULT6B1 Gene

Drugs & Compounds for SULT6B1 Gene

(1) Drugs for SULT6B1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Levothyroxine Approved Pharma 0

(2) Additional Compounds for SULT6B1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
genes like me logo Genes that share compounds with SULT6B1: view

Transcripts for SULT6B1 Gene

mRNA/cDNA for SULT6B1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT6B1 Gene

Sulfotransferase family, cytosolic, 6B, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT6B1 Gene

No ASD Table

Relevant External Links for SULT6B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SULT6B1 Gene

mRNA expression in normal human tissues for SULT6B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT6B1 Gene

This gene is overexpressed in Testis (x48.0).

Protein differential expression in normal tissues from HIPED for SULT6B1 Gene

This gene is overexpressed in Testis (59.4) and Platelet (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SULT6B1 Gene

SOURCE GeneReport for Unigene cluster for SULT6B1 Gene Hs.631892

mRNA Expression by UniProt/SwissProt for SULT6B1 Gene

Tissue specificity: Specifically expressed in kidney and testis.
genes like me logo Genes that share expression patterns with SULT6B1: view

Protein tissue co-expression partners for SULT6B1 Gene

Primer Products

Orthologs for SULT6B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SULT6B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SULT6B1 35
  • 89.77 (n)
  • 87.5 (a)
SULT6B1 36
  • 74 (a)
(Canis familiaris)
Mammalia SULT6B1 35
  • 89.56 (n)
  • 89.81 (a)
SULT6B1 36
  • 77 (a)
(Mus musculus)
Mammalia Sult6b1 35
  • 84.66 (n)
  • 85.55 (a)
Sult6b1 16
Sult6b1 36
  • 74 (a)
(Pan troglodytes)
Mammalia SULT6B1 35
  • 98.87 (n)
  • 97.74 (a)
SULT6B1 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Sult6b1 35
  • 85.17 (n)
  • 83.65 (a)
(Monodelphis domestica)
Mammalia SULT6B1 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
(Gallus gallus)
Aves SULT6B1 35
  • 72.2 (n)
  • 64.91 (a)
SULT6B1 36
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
-- 36
  • 41 (a)
-- 36
  • 44 (a)
-- 36
  • 45 (a)
-- 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135365 35
  • 62.26 (n)
  • 53.21 (a)
(Danio rerio)
Actinopterygii sult6b1 35
  • 57.58 (n)
  • 50 (a)
sult6b1 36
  • 44 (a)
Species with no ortholog for SULT6B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT6B1 Gene

Gene Tree for SULT6B1 (if available)
Gene Tree for SULT6B1 (if available)

Paralogs for SULT6B1 Gene

(13) SIMAP similar genes for SULT6B1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SULT6B1: view

Variants for SULT6B1 Gene

Sequence variations from dbSNP and Humsavar for SULT6B1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs45552433 - 37,188,460(+) AGATG(C/T)TAGCA reference, missense
rs45626240 - 37,187,443(+) CACTG(A/T)CAATG reference, missense
rs45493492 - 37,187,405(-) AGTAT(A/G)AATAT reference, missense
rs7425881 - 37,179,487(+) AGAAT(A/T)CATCC reference, missense
rs45439591 - 37,175,213(-) GGAAG(A/C/G)TATTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SULT6B1 Gene

Variant ID Type Subtype PubMed ID
nsv2683 CNV Insertion 18451855

Variation tolerance for SULT6B1 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.33; 90.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SULT6B1 Gene

Disorders for SULT6B1 Gene

Relevant External Links for SULT6B1

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SULT6B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SULT6B1 Gene

Publications for SULT6B1 Gene

  1. Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. (PMID: 14676822) Freimuth R.R. … Weinshilboum R.M. (Pharmacogenomics J. 2004) 2 3 4 67
  2. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3
  3. Genome-wide association study of schizophrenia in a Japanese population. (PMID: 20832056) Ikeda M. … Iwata N. (Biol. Psychiatry 2011) 3
  4. Structural and chemical profiling of the human cytosolic sulfotransferases. (PMID: 17425406) Allali-Hassani A. … Arrowsmith C.H. (PLoS Biol. 2007) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3

Products for SULT6B1 Gene

Sources for SULT6B1 Gene