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Aliases for SULT4A1 Gene

Aliases for SULT4A1 Gene

  • Sulfotransferase Family 4A, Member 1 2 3
  • Brain Sulfotransferase-Like Protein 3 4
  • Nervous System Sulfotransferase 3 4
  • HBR-STL-1 3 4
  • HBR-STL 3 4
  • BRSTL1 3 6
  • SULTX3 3 4
  • ST4A1 3 4
  • NST 3 4
  • Nervous System Cytosolic Sulfotransferase 3
  • Sulfotransferase-Related Protein 3
  • Sulfotransferase 4A1 3
  • EC 2.8.2.- 4
  • DJ388M5.3 3
  • BR-STL-1 3

External Ids for SULT4A1 Gene

Summaries for SULT4A1 Gene

Entrez Gene Summary for SULT4A1 Gene

  • This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT4A1 Gene

SULT4A1 (Sulfotransferase Family 4A, Member 1) is a Protein Coding gene. Diseases associated with SULT4A1 include schizotypal personality disorder and schizophrenia. Among its related pathways are Metabolism and Biological oxidations. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT4A1 Gene

  • Atypical sulfotransferase family member with very low affinity for 3-phospho-5-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.

Gene Wiki entry for SULT4A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT4A1 Gene

Genomics for SULT4A1 Gene

Genomic Location for SULT4A1 Gene

Start:
43,824,507 bp from pter
End:
43,862,503 bp from pter
Size:
37,997 bases
Orientation:
Minus strand

Genomic View for SULT4A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SULT4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT4A1 Gene

Regulatory Elements for SULT4A1 Gene

Proteins for SULT4A1 Gene

  • Protein details for SULT4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR01-ST4A1_HUMAN
    Recommended name:
    Sulfotransferase 4A1
    Protein Accession:
    Q9BR01
    Secondary Accessions:
    • B2R7N3
    • O43728

    Protein attributes for SULT4A1 Gene

    Size:
    284 amino acids
    Molecular mass:
    33085 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT4A1 Gene

    Alternative splice isoforms for SULT4A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT4A1 Gene

Proteomics data for SULT4A1 Gene at MOPED

Post-translational modifications for SULT4A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT4A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SULT4A1 Gene

Domains for SULT4A1 Gene

Gene Families for SULT4A1 Gene

HGNC:
  • SULT :Sulfotransferases, cytosolic

Protein Domains for SULT4A1 Gene

UniProtKB/Swiss-Prot:

ST4A1_HUMAN
Family:
  • Belongs to the sulfotransferase 1 family.:
    • Q9BR01
genes like me logo Genes that share domains with SULT4A1: view

Function for SULT4A1 Gene

Molecular function for SULT4A1 Gene

UniProtKB/Swiss-Prot Function: Atypical sulfotransferase family member with very low affinity for 3-phospho-5-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.

Enzyme Numbers (IUBMB) for SULT4A1 Gene

Gene Ontology (GO) - Molecular Function for SULT4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19439498
GO:0008146 sulfotransferase activity NAS 10698717
genes like me logo Genes that share ontologies with SULT4A1: view

Phenotypes for SULT4A1 Gene

GenomeRNAi human phenotypes for SULT4A1:
genes like me logo Genes that share phenotypes with SULT4A1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SULT4A1 Gene

Localization for SULT4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT4A1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT4A1 Gene COMPARTMENTS Subcellular localization image for SULT4A1 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SULT4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT4A1: view

Pathways for SULT4A1 Gene

genes like me logo Genes that share pathways with SULT4A1: view

Pathways by source for SULT4A1 Gene

Interacting Proteins for SULT4A1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332565%0d%0a9606.ENSP00000247970%0d%0a9606.ENSP00000350249%0d%0a9606.ENSP00000335153%0d%0a
Selected Interacting proteins: ENSP00000332565 Q9BR01-ST4A1_HUMAN for SULT4A1 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SULT4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006790 sulfur compound metabolic process --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008150 biological_process ND --
GO:0008202 steroid metabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with SULT4A1: view

Transcripts for SULT4A1 Gene

Unigene Clusters for SULT4A1 Gene

Sulfotransferase family 4A, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT4A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d
SP1:
SP2: -
SP3: -
SP4: -
SP5: - - - -
SP6: - - - - -

Relevant External Links for SULT4A1 Gene

GeneLoc Exon Structure for
SULT4A1
ECgene alternative splicing isoforms for
SULT4A1

Expression for SULT4A1 Gene

mRNA expression in normal human tissues for SULT4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT4A1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.1), Brain - Cortex (8.0), Brain - Anterior cingulate cortex (BA24) (6.9), and Brain - Hippocampus (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SULT4A1 Gene

SOURCE GeneReport for Unigene cluster for SULT4A1 Gene Hs.189810

mRNA Expression by UniProt/SwissProt for SULT4A1 Gene

Q9BR01-ST4A1_HUMAN
Tissue specificity: Highly expressed in the cerebral cortex and frontal lobe, slightly less in the cerebellum, occipital and temporal lobes, relatively low in the medulla and putamen, and lowest in the spinal cord. No expression detected in the pancreas (PubMed:10698717). Highly expressed in fetal brain and occipital lobe, slightly less in the whole brain, frontal lobe, hippocampus, and lung, very low expression in cerebellum, medulla oblongata, temporal lobe, testis, kidney and appendix (PubMed:12039030).
genes like me logo Genes that share expressions with SULT4A1: view

Orthologs for SULT4A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT4A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT4A1 36
  • 99.77 (n)
  • 99.65 (a)
SULT4A1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SULT4A1 36
  • 92.72 (n)
  • 99.3 (a)
SULT4A1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SULT4A1 36
  • 94.48 (n)
  • 99.65 (a)
SULT4A1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sult4a1 36
  • 91.55 (n)
  • 97.89 (a)
Sult4a1 16
Sult4a1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SULT4A1 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SULT4A1 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sult4a1 36
  • 91.08 (n)
  • 97.89 (a)
chicken
(Gallus gallus)
Aves SULT4A1 36
  • 79.91 (n)
  • 94.32 (a)
SULT4A1 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SULT4A1 37
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sult4a1 36
  • 79.23 (n)
  • 90.49 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.19215 36
sult4a1 36
  • 78.29 (n)
  • 86.62 (a)
sult4a1 37
  • 87 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta St2 37
  • 30 (a)
OneToMany
CG6704 38
  • 32 (a)
CG5428 38
  • 32 (a)
CG16733 38
  • 33 (a)
Species with no ortholog for SULT4A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT4A1 Gene

ENSEMBL:
Gene Tree for SULT4A1 (if available)
TreeFam:
Gene Tree for SULT4A1 (if available)

Paralogs for SULT4A1 Gene

Selected SIMAP similar genes for SULT4A1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SULT4A1: view

Variants for SULT4A1 Gene

Sequence variations from dbSNP and Humsavar for SULT4A1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs78509 -- 43,849,106(+) AACTC(C/T)CCAGG intron-variant
rs80627 -- 43,849,201(+) CAGAA(C/T)GGCCT intron-variant
rs80628 -- 43,849,299(+) GGAAA(G/T)ATGGG intron-variant
rs80637 -- 43,846,187(+) CGACA(C/T)TGGTG intron-variant
rs138055 -- 43,824,411(+) GGGAA(C/T)GGGGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SULT4A1 Gene

Variant ID Type Subtype PubMed ID
nsv834217 CNV Gain 17160897
nsv834218 CNV Loss 17160897
dgv4998n71 CNV Loss 21882294
nsv915258 CNV Loss 21882294
dgv4999n71 CNV Loss 21882294
nsv915260 CNV Loss 21882294
nsv829263 CNV Gain 20364138
nsv3647 CNV Loss 18451855
nsv829265 CNV Loss 20364138
esv2510122 CNV Deletion 19546169
nsv512659 CNV Loss 21212237
nsv191452 CNV Loss 16902084
esv28783 CNV Loss 19812545
esv1037241 CNV Deletion 17803354
esv1523199 CNV Deletion 17803354
esv1538910 CNV Deletion 17803354
esv2724327 CNV Deletion 23290073
esv2724329 CNV Deletion 23290073
nsv834219 CNV Gain 17160897

Relevant External Links for SULT4A1 Gene

HapMap Linkage Disequilibrium report
SULT4A1
Human Gene Mutation Database (HGMD)
SULT4A1

Disorders for SULT4A1 Gene

(1) University of Copenhagen DISEASES for SULT4A1 Gene

Relevant External Links for SULT4A1

Genetic Association Database (GAD)
SULT4A1
Human Genome Epidemiology (HuGE) Navigator
SULT4A1
genes like me logo Genes that share disorders with SULT4A1: view

No data available for UniProtKB/Swiss-Prot for SULT4A1 Gene

Publications for SULT4A1 Gene

  1. Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain. (PMID: 10698717) Falany C.N. … Falany J.L. (Biochem. J. 2000) 2 3 4 23
  2. Association of Sult4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder. (PMID: 18823757) Meltzer H.Y. … Jayathilake K. (Schizophr. Res. 2008) 3 23 49
  3. Lack of exonic sulfotransferase 4A1 mutations in controls and schizophrenia cases. (PMID: 19125109) Lewis A.G. … Minchin R.F. (Psychiatr. Genet. 2009) 3 23 49
  4. Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1. (PMID: 19439498) Mitchell D.J. … Minchin R.F. (Mol. Pharmacol. 2009) 3 23
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4

Products for SULT4A1 Gene

Sources for SULT4A1 Gene

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