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Aliases for SULT2B1 Gene

Aliases for SULT2B1 Gene

  • Sulfotransferase Family, Cytosolic, 2B, Member 1 2 3
  • Hydroxysteroid Sulfotransferase 2 3 4
  • Alcohol Sulfotransferase 3 4
  • Sulfotransferase 2B1 3 4
  • HSST2 3 4
  • ST2B1 3 4
  • Sulfotransferase Family Cytosolic 2B Member 1 3
  • EC 2.8.2.2 4
  • EC 2.8.2 63

External Ids for SULT2B1 Gene

Previous GeneCards Identifiers for SULT2B1 Gene

  • GC19P049699
  • GC19P049423
  • GC19P053731
  • GC19P053747
  • GC19P049055
  • GC19P045434

Summaries for SULT2B1 Gene

Entrez Gene Summary for SULT2B1 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT2B1 Gene

SULT2B1 (Sulfotransferase Family, Cytosolic, 2B, Member 1) is a Protein Coding gene. Among its related pathways are Metabolism and Vitamin A and carotenoid metabolism. GO annotations related to this gene include steroid sulfotransferase activity and alcohol sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT2B1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.

Gene Wiki entry for SULT2B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT2B1 Gene

Genomics for SULT2B1 Gene

Regulatory Elements for SULT2B1 Gene

Genomic Location for SULT2B1 Gene

Start:
48,552,075 bp from pter
End:
48,599,427 bp from pter
Size:
47,353 bases
Orientation:
Plus strand

Genomic View for SULT2B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SULT2B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT2B1 Gene

Proteins for SULT2B1 Gene

  • Protein details for SULT2B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00204-ST2B1_HUMAN
    Recommended name:
    Sulfotransferase family cytosolic 2B member 1
    Protein Accession:
    O00204
    Secondary Accessions:
    • O00205
    • O75814

    Protein attributes for SULT2B1 Gene

    Size:
    365 amino acids
    Molecular mass:
    41308 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT2B1 Gene

    Alternative splice isoforms for SULT2B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT2B1 Gene

Proteomics data for SULT2B1 Gene at MOPED

Selected DME Specific Peptides for SULT2B1 Gene

Post-translational modifications for SULT2B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT2B1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SULT2B1 Gene

Gene Families for SULT2B1 Gene

HGNC:
  • SULT :Sulfotransferases, cytosolic

Protein Domains for SULT2B1 Gene

Suggested Antigen Peptide Sequences for SULT2B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00204

UniProtKB/Swiss-Prot:

ST2B1_HUMAN :
  • O00204
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT2B1: view

Function for SULT2B1 Gene

Molecular function for SULT2B1 Gene

GENATLAS Biochemistry: hydroxysteroid sulfotransferase,highly expressed in placenta,prostate,trachea,with two isoforms SULT2B1A and SULT2B1B
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=10.9 uM for DHEA (at 37 degrees Celsius, in the presence of 1mM MgCl2) {ECO:0000269 PubMed:16855051, ECO:0000269 PubMed:21855633}; KM=3.8 uM for DHEA (at 37 degrees Celsius, in the presence of 10mM MgCl2) {ECO:0000269 PubMed:16855051, ECO:0000269 PubMed:21855633}; KM=11.8 uM for pregnenolone (at 37 degrees Celsius, in the presence of 1mM MgCl2) {ECO:0000269 PubMed:16855051, ECO:0000269 PubMed:21855633}; KM=0.6 uM for PAPS (at 37 degrees Celsius, in the presence of 1mM MgCl2) {ECO:0000269 PubMed:16855051, ECO:0000269 PubMed:21855633}; Vmax=1752 pmol/min/mg enzyme toward DHEA (at 37 degrees Celsius, in the presence of 10 mM MgCl2) {ECO:0000269 PubMed:16855051, ECO:0000269 PubMed:21855633}; Temperature dependence: Optimum temperature is 37 degrees Celsius. Retains 70% and 20% of activity when incubated at 42 degrees Celsius for 45 and 120 minutes, respectively. Activity is lost after 200 minutes incubation at 42 degrees Celsius. {ECO:0000269 PubMed:16855051, ECO:0000269 PubMed:21855633};
UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + an alcohol = adenosine 3,5-bisphosphate + an alkyl sulfate
UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.

Enzyme Numbers (IUBMB) for SULT2B1 Gene

Gene Ontology (GO) - Molecular Function for SULT2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004027 alcohol sulfotransferase activity TAS --
GO:0005515 protein binding IPI 16189514
GO:0008146 sulfotransferase activity --
GO:0050294 steroid sulfotransferase activity IDA 12145317
genes like me logo Genes that share ontologies with SULT2B1: view

Phenotypes for SULT2B1 Gene

MGI mutant phenotypes for SULT2B1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SULT2B1: view

Animal Models for SULT2B1 Gene

MGI Knock Outs for SULT2B1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for SULT2B1 Gene

Localization for SULT2B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT2B1 Gene

Cytoplasm. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT2B1 Gene COMPARTMENTS Subcellular localization image for SULT2B1 gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SULT2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SULT2B1: view

Pathways for SULT2B1 Gene

genes like me logo Genes that share pathways with SULT2B1: view

Pathways by source for SULT2B1 Gene

1 KEGG pathway for SULT2B1 Gene
1 GeneGo (Thomson Reuters) pathway for SULT2B1 Gene

Gene Ontology (GO) - Biological Process for SULT2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000103 sulfate assimilation IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IDA 12145317
GO:0044281 small molecule metabolic process TAS --
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
genes like me logo Genes that share ontologies with SULT2B1: view

Compounds for SULT2B1 Gene

(12) HMDB Compounds for SULT2B1 Gene

Compound Synonyms Cas Number PubMed IDs
1-Butanol
  • 1-Butanol
71-36-3
1-Hexanol
  • 1-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
71-41-0
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Androsterone sulfate
  • 3alpha-Sulfate-5alpha-androstan-17-one
2479-86-9

(4) Drugbank Compounds for SULT2B1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine-3'-5'-Diphosphate
target
Dehydroepiandrosterone
  • 3-beta-Hydroxy-5-androsten-17-one
53-43-0 target
N-Cyclohexyltaurine
target
Pregnenolone
target

(4) Novoseek inferred chemical compound relationships for SULT2B1 Gene

Compound -log(P) Hits PubMed IDs
hydroxysteroid 92.7 3
cholesterol 47.4 3
sterol 46.7 4
steroid 37.2 3

(5) PharmGKB related drug/compound annotations for SULT2B1 Gene

genes like me logo Genes that share compounds with SULT2B1: view

Transcripts for SULT2B1 Gene

mRNA/cDNA for SULT2B1 Gene

(3) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT2B1 Gene

Sulfotransferase family, cytosolic, 2B, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT2B1 Gene

No ASD Table

Relevant External Links for SULT2B1 Gene

GeneLoc Exon Structure for
SULT2B1
ECgene alternative splicing isoforms for
SULT2B1

Expression for SULT2B1 Gene

mRNA expression in normal human tissues for SULT2B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT2B1 Gene

This gene is overexpressed in Esophagus - Mucosa (16.1), Skin - Sun Exposed (Lower leg) (9.2), Skin - Not Sun Exposed (Suprapubic) (8.8), Vagina (6.5), and Cervix - Ectocervix (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SULT2B1 Gene

SOURCE GeneReport for Unigene cluster for SULT2B1 Gene Hs.369331

mRNA Expression by UniProt/SwissProt for SULT2B1 Gene

O00204-ST2B1_HUMAN
Tissue specificity: Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.
genes like me logo Genes that share expressions with SULT2B1: view

Orthologs for SULT2B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SULT2B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT2B1 35
  • 98.9 (n)
  • 98.35 (a)
SULT2B1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SULT2B1 35
  • 83.53 (n)
  • 78.99 (a)
SULT2B1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SULT2B1 35
  • 88.11 (n)
  • 86.71 (a)
SULT2B1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sult2b1 35
  • 79.19 (n)
  • 78.34 (a)
Sult2b1 16
Sult2b1 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SULT2B1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SULT2B1 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sult2b1 35
  • 81.51 (n)
  • 80.48 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 52 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
LOC769841 35
  • 61.03 (n)
  • 52.76 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.23902 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100144919 35
  • 58.06 (n)
  • 50.18 (a)
Str.5857 35
zebrafish
(Danio rerio)
Actinopterygii Dr.25239 35
si:dkey-236e20.1 36
  • 44 (a)
ManyToMany
sult2st3 35
  • 55.04 (n)
  • 50 (a)
Species with no ortholog for SULT2B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT2B1 Gene

ENSEMBL:
Gene Tree for SULT2B1 (if available)
TreeFam:
Gene Tree for SULT2B1 (if available)

Paralogs for SULT2B1 Gene

Selected SIMAP similar genes for SULT2B1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SULT2B1: view

Variants for SULT2B1 Gene

Sequence variations from dbSNP and Humsavar for SULT2B1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs175924 -- 48,562,633(-) AAACT(A/G)TGATC intron-variant
rs279445 -- 48,562,218(-) gtaga(A/G)acggg intron-variant
rs279446 -- 48,554,717(-) cactg(C/T)gctcc intron-variant
rs279447 -- 48,552,539(-) TCCCC(A/G)CTGGT intron-variant
rs279448 -- 48,551,600(-) GGGCA(C/T)GGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SULT2B1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912223 CNV Loss 21882294
nsv817853 CNV Loss 17921354
nsv510882 CNV Complex 20534489
nsv507899 CNV Insertion 20534489
dgv3966n71 CNV Loss 21882294
nsv912225 CNV Loss 21882294
dgv3967n71 CNV Loss 21882294
nsv912228 CNV Loss 21882294
nsv138413 CNV Loss 16902084

Relevant External Links for SULT2B1 Gene

HapMap Linkage Disequilibrium report
SULT2B1
Human Gene Mutation Database (HGMD)
SULT2B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT2B1 Gene

Disorders for SULT2B1 Gene

(1) University of Copenhagen DISEASES for SULT2B1 Gene

Relevant External Links for SULT2B1

Genetic Association Database (GAD)
SULT2B1
Human Genome Epidemiology (HuGE) Navigator
SULT2B1
genes like me logo Genes that share disorders with SULT2B1: view

No data available for UniProtKB/Swiss-Prot for SULT2B1 Gene

Publications for SULT2B1 Gene

  1. Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene. (PMID: 9799594) Her C. … Weinshilboum R.M. (Genomics 1998) 2 3 4 23
  2. Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase. (PMID: 12145317) Fuda H. … Strott C.A. (J. Biol. Chem. 2002) 3 4 23
  3. Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms. (PMID: 12923182) Lee K.A. … Pedersen L.C. (J. Biol. Chem. 2003) 3 4 23
  4. Different subcellular localization of sulphotransferase 2B1b in human placenta and prostate. (PMID: 14741047) He D. … Falany C.N. (Biochem. J. 2004) 3 23
  5. Identification and immunohistochemical localization of Sulfotransferase 2B1b (SULT2B1b) in human lung. (PMID: 15878639) He D. … Falany C.N. (Biochim. Biophys. Acta 2005) 3 23

Products for SULT2B1 Gene

Sources for SULT2B1 Gene

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