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SULT2B1 Gene

protein-coding   GIFtS: 69
GCID: GC19P049055

Sulfotransferase Family, Cytosolic, 2B, Member 1

  See SULT2B1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sulfotransferase Family, Cytosolic, 2B, Member 11 2     ST2B12 3
Alcohol Sulfotransferase2 3     Sulfotransferase Family Cytosolic 2B Member 12
Hydroxysteroid Sulfotransferase 22 3     EC 2.8.2.23
Sulfotransferase 2B12 3     EC 2.8.28
HSST22 3     

External Ids:    HGNC: 114591   Entrez Gene: 68202   Ensembl: ENSG000000880027   OMIM: 6041255   UniProtKB: O002043   

Export aliases for SULT2B1 gene to outside databases

Previous GC identifers: GC19P049699 GC19P049423 GC19P053731 GC19P053747 GC19P045434


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SULT2B1 Gene:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and
xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate
specificities. The gene structure (number and length of exons) is similar among family members. This gene
sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen
sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been
described. (provided by RefSeq, Jul 2008)

GeneCards Summary for SULT2B1 Gene:
SULT2B1 (sulfotransferase family, cytosolic, 2B, member 1) is a protein-coding gene. Diseases associated with SULT2B1 include variegate porphyria. GO annotations related to this gene include steroid sulfotransferase activity and alcohol sulfotransferase activity. An important paralog of this gene is SULT1C3.

UniProtKB/Swiss-Prot: ST2B1_HUMAN, O00204
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases
the water solubility of most compounds, and therefore their renal excretion, but it can also result in
bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates
cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol

Gene Wiki entry for SULT2B1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SULT2B1 gene promoter:
         Egr-3   C/EBPbeta   Lmo2   AP-4   C/EBPalpha   RORalpha2   Nkx6-1   FOXO4   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSULT2B1 promoter sequence
   Search Chromatin IP Primers for SULT2B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SULT2B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

SULT2B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT2B1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049055:  view genomic region     (about GC identifiers)

Start:
49,055,332 bp from pter      End:
49,102,684 bp from pter
Size:
47,353 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ST2B1_HUMAN, O00204 (See protein sequence)
Recommended Name: Sulfotransferase family cytosolic 2B member 1  
Size: 365 amino acids; 41308 Da
4 PDB 3D structures from and Proteopedia for SULT2B1:
1Q1Q (3D)        1Q1Z (3D)        1Q20 (3D)        1Q22 (3D)    
Secondary accessions: O00205 O75814
Alternative splicing: 2 isoforms:  O00204-1   O00204-2   

Explore the universe of human proteins at neXtProt for SULT2B1: NX_O00204

Explore proteomics data for SULT2B1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for SULT2B1 (O00204)
     PKSGTTW  GDWKNHFTVAQ 


    See SULT2B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004596.2  NP_814444.1  

    ENSEMBL proteins: 
     ENSP00000201586   ENSP00000312880  
    Reactome Protein details: O00204

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULT: Sulfotransferases, cytosolic

    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry O00204

    ProtoNet protein and cluster: O00204

    1 Blocks protein domain: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST2B1_HUMAN, O00204
    Similarity: Belongs to the sulfotransferase 1 family


    Find genes that share domains with SULT2B1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST2B1_HUMAN, O00204
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases
    the water solubility of most compounds, and therefore their renal excretion, but it can also result in
    bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates
    cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol
    Catalytic activity: 3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate
    Biophysicochemical properties: Kinetic parameters: KM=10.9 uM for DHEA (at 37 degrees Celsius, in the presence of
    1mM MgCl2); KM=3.8 uM for DHEA (at 37 degrees Celsius, in the presence of 10mM MgCl2); KM=11.8 uM for
    pregnenolone (at 37 degrees Celsius, in the presence of 1mM MgCl2); KM=0.6 uM for PAPS (at 37 degrees Celsius, in
    the presence of 1mM MgCl2); Vmax=1752 pmol/min/mg enzyme toward DHEA (at 37 degrees Celsius, in the presence of
    10 mM MgCl2); Temperature dependence: Optimum temperature is 37 degrees Celsius. Retains 70% and 20% of activity
    when incubated at 42 degrees Celsius for 45 and 120 minutes, respectively. Activity is lost after 200 minutes
    incubation at 42 degrees Celsius;

         Genatlas biochemistry entry for SULT2B1:
    hydroxysteroid sulfotransferase,highly expressed in placenta,prostate,trachea,with two isoforms SULT2B1A and
    SULT2B1B

         Enzyme Numbers (IUBMB): EC 2.8.22 EC 2.8.2.21

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004027alcohol sulfotransferase activity TAS--
    GO:0005515protein binding IPI16189514
    GO:0008146sulfotransferase activity ----
    GO:0050294steroid sulfotransferase activity IDA12145317
         
    Find genes that share ontologies with SULT2B1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sult2b1):
     homeostasis/metabolism 

    Find genes that share phenotypes with SULT2B1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sult2b1tm1Rus for SULT2B1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SULT2B1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ST2B1_HUMAN, O00204: Cytoplasm. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation
    to the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    endoplasmic reticulum3
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005829cytosol TAS--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with SULT2B1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SULT2B1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    Cytosolic sulfonation of small molecules0.00
    2Estrone metabolism
    Estrone metabolism0.57
    3Metabolism
    Metabolism0.38
    4Vitamin A and carotenoid metabolism
    Vitamin A and carotenoid metabolism
    5Sulfation Biotransformation Reaction
    Sulfation Biotransformation Reaction


    Find genes that share SuperPaths with SULT2B1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for SULT2B1
        Estrone metabolism

    3 BioSystems Pathways for SULT2B1
        Vitamin A and carotenoid metabolism
    Sulfation Biotransformation Reaction
    metapathway biotransformation


    1 Reactome Pathway for SULT2B1
        Cytosolic sulfonation of small molecules


    1 Kegg Pathway  (Kegg details for SULT2B1):
        Steroid hormone biosynthesis

        Pathway & Disease-focused RT2 Profiler PCR Array including SULT2B1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SULT2B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SULT2B1 (O002041, 2, 3 ENSP000002015864) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALS2CR12Q96Q351, 2, 3, ENSP000002861904EBI-749441,EBI-750451 MINT-67791 I2D: score=3 STRING: ENSP00000286190
    SULT1E1P498882, 3, ENSP000002264444MINT-67530 I2D: score=5 STRING: ENSP00000226444
    CYP11A1ENSP000002680534STRING: ENSP00000268053
    CYP17A1ENSP000003589034STRING: ENSP00000358903
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000103sulfate assimilation IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008202steroid metabolic process IDA12145317
    GO:0044281small molecule metabolic process TAS--
    GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process TAS--

    Find genes that share ontologies with SULT2B1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SULT2B1 (ST2B1)

    Selected HMDB Compounds for SULT2B1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Androsterone sulfate3alpha-Sulfate-5alpha-androstan-17-one (see all 8)2479-86-9--
    DHEA sulfate(3beta)-3-(sulfooxy)-Androst-5-en-17-one (see all 16)651-48-9--
    Dehydroepiandrosterone(+)-Dehydroisoandrosterone (see all 42)53-43-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--
    Isopropyl alcohol2-Propanol (see all 12)67-63-0--

    4 DrugBank Compounds for SULT2B1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dehydroepiandrosterone3-beta-Hydroxy-5-androsten-17-one (see all 6)53-43-0target--17139284 17016423 10592235
    Pregnenolone-- --target--17139284 17016423 10592235
    Adenosine-3'-5'-Diphosphate-- --target--17139284 17016423
    N-Cyclohexyltaurine-- --target--17139284 17016423

    4 Novoseek inferred chemical compound relationships for SULT2B1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxysteroid 92.7 3 12145317 (1), 12923182 (1), 9799594 (1)
    cholesterol 47.4 3 12145317 (2), 15953604 (1)
    sterol 46.7 6 16368200 (3), 15953604 (1)
    steroid 37.2 5 15953604 (1), 16368200 (1), 19308726 (1)

    5 PharmGKB related drug/compound annotations for SULT2B1 gene    About this table
    Drug/compound PharmGKB Annotation
    anthracyclines and related substancesCA  
    cytarabineCA  
    fludarabineCA  
    gemtuzumab ozogamicinCA  
    idarubicinCA  



    Find genes that share compounds with SULT2B1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SULT2B1 gene (2 alternative transcripts): 
    NM_004605.2  NM_177973.1  

    Unigene Cluster for SULT2B1:

    Sulfotransferase family, cytosolic, 2B, member 1
    Hs.369331  [show with all ESTs]
    Unigene Representative Sequence: U92314
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000201586(uc002pjl.3) ENST00000323090(uc002pjm.3) ENST00000594274
    ENST00000597923
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      QuantiFast Probe-based Assays in human, mouse, rat SULT2B1

    Additional mRNA sequence: 

    BC034694.1 U92314.1 U92315.1 

    5 DOTS entries:

    DT.211063  DT.100754391  DT.99935825  DT.121504405  DT.92425852 

    6 AceView cDNA sequences:

    NM_177973 BC034694 NM_004605 U92314 AK096418 U92315 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SULT2B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAACTACA
    SULT2B1 Expression
    About this image


    SULT2B1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Lung (Respiratory System)
             Stem Bronchi
     
     Eye (Sensory Organs)
             Lens
     
     Esophagus (Gastrointestinal Tract)
    SULT2B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SULT2B1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369331

    UniProtKB/Swiss-Prot: ST2B1_HUMAN, O00204
    Tissue specificity: Expressed highly in placenta, prostate and trachea and lower expression in the small intestine
    and lung

        Pathway & Disease-focused RT2 Profiler PCR Array including SULT2B1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT2B1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SULT2B1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sult2b11 , 5 sulfotransferase family, cytosolic, 2B, member 11, 5 79.19(n)1
    78.34(a)1
      7 (29.47 cM)5
    542001  NM_017465.21  NP_059493.21 
     457299835 
    chicken
    (Gallus gallus)
    Aves LOC7698411 sulfotransferase family cytosolic 2B member 1-like 61.03(n)
    52.76(a)
      769841  XM_001233157.3  XP_001233158.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    56(a)
    48(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    GL343279.1(995519-1007431)
    GL343276.1(33115-42708)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.239022 Xenopus laevis transcribed sequence with weak similarity more 74.9(n)    CB565072.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.252392 Transcribed sequence with weak similarity to protein more 77.25(n)    CD014631.1 


    ENSEMBL Gene Tree for SULT2B1 (if available)
    TreeFam Gene Tree for SULT2B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SULT2B1 gene
    SULT1C32  SULT4A12  SULT1B12  SULT1A22  SULT1C42  SULT1C22  SULT1E12  SULT1A42  
    SULT2A12  SULT6B12  SULT1A12  SULT1A32  
    12 SIMAP similar genes for SULT2B1 using alignment to 1 protein entry:     ST2B1_HUMAN:
    SULT2A1    SULT1C4    SULT1A1    SULT1E1    SULT1C2    ST1A5
    SULT1A2    SULT1A3    SULT1A4    SULT1B1    SULT1C3    SULT6B1

    Find genes that share paralogs with SULT2B1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SULT2B1 (see all 1441)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1113469531,2
    C,F--49054093(+) GCCTCG/AGCCTC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1426550431,2
    C--49058807(+) ACATC-/CTCT  
      CTCTCT
    CTCTC
    1 -- int10--------
    rs589979331,2
    C--49058846(+) TCTCT-/C/CTCTC
    TCTCTCTCT
    TTTGA
    1 -- int11NA 2
    rs3702512071,2
    C--49060051(+) AAAAT-/AAAAAA 1 -- int10--------
    rs572884721,2
    C--49060206(+) AAAAA-/AGTTGT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs559616841,2
    C--49061593(+) AGGCGT/-TAGCA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs677312481,2
    C--49062606(-) CAAAA-/CAAAA 
            
    AACAA
    1 -- int11Minor allele frequency- CAAAA:0.00NA 2
    rs711790091,2
    C--49064724(-) AATTA-/A/    
       ATTTA
    TTTAT
    1 -- int11NA 2
    rs1127103681,2
    C,F--49065632(+) GAGCGG/AAACTC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1113317851,2
    C--49065648(+) CAAAAA/C/TAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SULT2B1 (49055332 - 49102684 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SULT2B1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507899CNV Insertion20534489
    nsv912225CNV Loss21882294
    dgv3966n71CNV Loss21882294
    nsv138413CNV Loss16902084
    dgv3967n71CNV Loss21882294
    nsv912228CNV Loss21882294
    nsv912223CNV Loss21882294
    nsv817853CNV Loss17921354
    nsv9739CNV Gain+Loss18304495
    nsv510882CNV Complex20534489

    Human Gene Mutation Database (HGMD): SULT2B1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SULT2B1
    DNA2.0 Custom Variant and Variant Library Synthesis for SULT2B1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604125    OMIM disorders: --

    1 disease for SULT2B1:    
    About MalaCards
    variegate porphyria

    1 disease from the University of Copenhagen DISEASES database for SULT2B1:
    Variegate porphyria

    Find genes that share disorders with SULT2B1           About GenesLikeMe

    Genetic Association Database (GAD): SULT2B1
    Human Genome Epidemiology (HuGE) Navigator: SULT2B1 (4 documents)

    Export disorders for SULT2B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SULT2B1 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with SULT2B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene. (PubMed id 9799594)1, 2, 3, 9 Her C.... Weinshilboum R.M. (Genomics 1998)
    2. Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase. (PubMed id 12145317)1, 2, 9 Fuda H.... Strott C.A. (J. Biol. Chem. 2002)
    3. Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms. (PubMed id 12923182)1, 2, 9 Lee K.A.... Pedersen L.C. (J. Biol. Chem. 2003)
    4. Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. (PubMed id 20214802)1, 4 Li J....Hall P. (Breast Cancer Res. 2010)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    6. Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)1, 4 Saito T....Kawata S. (Biochem. Biophys. Res. Commun. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    9. Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b). (PubMed id 11457664)1, 9 Meloche C.A. and Falany C.N. (J. Steroid Biochem. Mol. Biol. 2001)
    10. Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics. (PubMed id 17496163)1, 9 Ji Y....Weinshilboum R.M. (J. Pharmacol. Exp. Ther. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6820 HGNC: 11459 AceView: SULT2B1 Ensembl:ENSG00000088002 euGenes: HUgn6820
    ECgene: SULT2B1 Kegg: 6820 H-InvDB: SULT2B1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SULT2B1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SULT2B1 gene:
    Search GeneIP for patents involving SULT2B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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