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Aliases for SULT2B1 Gene

Aliases for SULT2B1 Gene

  • Sulfotransferase Family 2B Member 1 2 3 5
  • Sulfotransferase Family, Cytosolic, 2B, Member 1 2 3
  • Hydroxysteroid Sulfotransferase 2 3 4
  • Alcohol Sulfotransferase 3 4
  • Sulfotransferase 2B1 3 4
  • HSST2 3 4
  • ST2B1 3 4
  • EC 2.8.2.2 4
  • EC 2.8.2 63

External Ids for SULT2B1 Gene

Previous GeneCards Identifiers for SULT2B1 Gene

  • GC19P049699
  • GC19P049423
  • GC19P053731
  • GC19P053747
  • GC19P049055
  • GC19P045434

Summaries for SULT2B1 Gene

Entrez Gene Summary for SULT2B1 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT2B1 Gene

SULT2B1 (Sulfotransferase Family 2B Member 1) is a Protein Coding gene. Diseases associated with SULT2B1 include Chromosome 18Q Deletion Syndrome and Chromosome 18P Deletion Syndrome. Among its related pathways are Phase II conjugation and Vitamin A and carotenoid metabolism. GO annotations related to this gene include sulfotransferase activity and alcohol sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT2B1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.

Gene Wiki entry for SULT2B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT2B1 Gene

Genomics for SULT2B1 Gene

Regulatory Elements for SULT2B1 Gene

Enhancers for SULT2B1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SULT2B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SULT2B1 Gene

Chromosome:
19
Start:
48,552,075 bp from pter
End:
48,599,427 bp from pter
Size:
47,353 bases
Orientation:
Plus strand

Genomic View for SULT2B1 Gene

Genes around SULT2B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT2B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT2B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT2B1 Gene

Proteins for SULT2B1 Gene

  • Protein details for SULT2B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00204-ST2B1_HUMAN
    Recommended name:
    Sulfotransferase family cytosolic 2B member 1
    Protein Accession:
    O00204
    Secondary Accessions:
    • O00205
    • O75814

    Protein attributes for SULT2B1 Gene

    Size:
    365 amino acids
    Molecular mass:
    41308 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT2B1 Gene

    Alternative splice isoforms for SULT2B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT2B1 Gene

Proteomics data for SULT2B1 Gene at MOPED

Selected DME Specific Peptides for SULT2B1 Gene

Post-translational modifications for SULT2B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT2B1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SULT2B1 Gene

Gene Families for SULT2B1 Gene

Protein Domains for SULT2B1 Gene

Suggested Antigen Peptide Sequences for SULT2B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00204

UniProtKB/Swiss-Prot:

ST2B1_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT2B1: view

Function for SULT2B1 Gene

Molecular function for SULT2B1 Gene

GENATLAS Biochemistry:
hydroxysteroid sulfotransferase,highly expressed in placenta,prostate,trachea,with two isoforms SULT2B1A and SULT2B1B
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=10.9 uM for DHEA (at 37 degrees Celsius, in the presence of 1 mM MgCl2) {ECO:0000269 PubMed:16855051, ECO:0000269 PubMed:21855633}; KM=3.8 uM for DHEA (at 37 degrees Celsius, in the presence of 10 mM MgCl2) {ECO:0000269 PubMed:16855051, ECO:0000269 PubMed:21855633}; KM=11.8 uM for pregnenolone (at 37 degrees Celsius, in the presence of 1 mM MgCl2) {ECO:0000269 PubMed:16855051, ECO:0000269 PubMed:21855633}; KM=0.6 uM for PAPS (at 37 degrees Celsius, in the presence of 1 mM MgCl2) {ECO:0000269 PubMed:16855051, ECO:0000269 PubMed:21855633}; Vmax=1752 pmol/min/mg enzyme toward DHEA (at 37 degrees Celsius, in the presence of 10 mM MgCl2) {ECO:0000269 PubMed:16855051, ECO:0000269 PubMed:21855633}; Temperature dependence: Optimum temperature is 37 degrees Celsius. Retains 70% and 20% of activity when incubated at 42 degrees Celsius for 45 and 120 minutes, respectively. Activity is lost after 200 minutes incubation at 42 degrees Celsius. {ECO:0000269 PubMed:16855051, ECO:0000269 PubMed:21855633};
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + an alcohol = adenosine 3,5-bisphosphate + an alkyl sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.

Enzyme Numbers (IUBMB) for SULT2B1 Gene

Gene Ontology (GO) - Molecular Function for SULT2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050294 steroid sulfotransferase activity IDA,TAS --
genes like me logo Genes that share ontologies with SULT2B1: view
genes like me logo Genes that share phenotypes with SULT2B1: view

Animal Models for SULT2B1 Gene

MGI Knock Outs for SULT2B1:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SULT2B1 Gene

Localization for SULT2B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT2B1 Gene

Cytoplasm. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT2B1 Gene COMPARTMENTS Subcellular localization image for SULT2B1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
endoplasmic reticulum 3
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for SULT2B1 Gene

Pathways & Interactions for SULT2B1 Gene

genes like me logo Genes that share pathways with SULT2B1: view

Pathways by source for SULT2B1 Gene

1 KEGG pathway for SULT2B1 Gene
1 GeneGo (Thomson Reuters) pathway for SULT2B1 Gene

Gene Ontology (GO) - Biological Process for SULT2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with SULT2B1: view

No data available for SIGNOR curated interactions for SULT2B1 Gene

Drugs & Compounds for SULT2B1 Gene

(13) Drugs for SULT2B1 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytarabine Approved, Investigational Pharma 1054
Fludarabine Approved Pharma DNA synthsis inhibitor 1075
Gemtuzumab ozogamicin Approved, Investigational, Withdrawn Pharma 0
Idarubicin Approved Pharma 202
Pregnenolone Experimental Pharma Target 0

(12) Additional Compounds for SULT2B1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
3beta-Hydroxypregn-5-en-20-one sulfate
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Androsterone sulfate
  • 3alpha-Sulfate-5alpha-androstan-17-one
  • 5alpha-Androsterone sulfate
  • 5alpha-Androsterone sulphate
  • Andros-S
  • Androsterone 3alpha-sulfate
2479-86-9
genes like me logo Genes that share compounds with SULT2B1: view

Transcripts for SULT2B1 Gene

mRNA/cDNA for SULT2B1 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT2B1 Gene

Sulfotransferase family, cytosolic, 2B, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT2B1 Gene

No ASD Table

Relevant External Links for SULT2B1 Gene

GeneLoc Exon Structure for
SULT2B1
ECgene alternative splicing isoforms for
SULT2B1

Expression for SULT2B1 Gene

mRNA expression in normal human tissues for SULT2B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT2B1 Gene

This gene is overexpressed in Esophagus - Mucosa (x16.1), Skin - Sun Exposed (Lower leg) (x9.2), Skin - Not Sun Exposed (Suprapubic) (x8.8), Vagina (x6.5), and Cervix - Ectocervix (x4.4).

Protein differential expression in normal tissues from HIPED for SULT2B1 Gene

This gene is overexpressed in Cervix (54.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SULT2B1 Gene



SOURCE GeneReport for Unigene cluster for SULT2B1 Gene Hs.369331

mRNA Expression by UniProt/SwissProt for SULT2B1 Gene

O00204-ST2B1_HUMAN
Tissue specificity: Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.
genes like me logo Genes that share expression patterns with SULT2B1: view

Primer Products

No data available for Protein tissue co-expression partners for SULT2B1 Gene

Orthologs for SULT2B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SULT2B1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SULT2B1 35
  • 83.53 (n)
  • 78.99 (a)
SULT2B1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SULT2B1 35
  • 88.11 (n)
  • 86.71 (a)
SULT2B1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sult2b1 35
  • 79.19 (n)
  • 78.34 (a)
Sult2b1 16
Sult2b1 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SULT2B1 35
  • 98.9 (n)
  • 98.35 (a)
SULT2B1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sult2b1 35
  • 81.51 (n)
  • 80.48 (a)
oppossum
(Monodelphis domestica)
Mammalia SULT2B1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SULT2B1 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC769841 35
  • 61.03 (n)
  • 52.76 (a)
-- 36
  • 52 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100144919 35
  • 58.06 (n)
  • 50.18 (a)
Str.5857 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23902 35
zebrafish
(Danio rerio)
Actinopterygii Dr.25239 35
sult2st3 35
  • 55.04 (n)
  • 50 (a)
si:dkey-236e20.1 36
  • 44 (a)
ManyToMany
Species with no ortholog for SULT2B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT2B1 Gene

ENSEMBL:
Gene Tree for SULT2B1 (if available)
TreeFam:
Gene Tree for SULT2B1 (if available)

Paralogs for SULT2B1 Gene

(12) SIMAP similar genes for SULT2B1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SULT2B1: view

Variants for SULT2B1 Gene

Sequence variations from dbSNP and Humsavar for SULT2B1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs16982149 - 48,576,021(+) CAGCT(C/T)GGCGG reference, missense
rs17842463 - 48,599,342(+) CAGAC(C/T)CAACT reference, missense
rs2302947 - 48,596,811(-) CACGA(C/T)GGAGC reference, missense
rs7256244 -- 48,556,262(+) GCTGG(A/T)CTAGC intron-variant
rs7257121 -- 48,573,807(+) AGCAA(C/T)GGAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SULT2B1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912223 CNV Loss 21882294
nsv817853 CNV Loss 17921354
nsv510882 CNV Complex 20534489
nsv507899 CNV Insertion 20534489
dgv3966n71 CNV Loss 21882294
nsv912225 CNV Loss 21882294
dgv3967n71 CNV Loss 21882294
nsv912228 CNV Loss 21882294
nsv138413 CNV Loss 16902084

Variation tolerance for SULT2B1 Gene

Residual Variation Intolerance Score: 79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULT2B1 Gene

Human Gene Mutation Database (HGMD)
SULT2B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT2B1 Gene

Disorders for SULT2B1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SULT2B1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 18q deletion syndrome
  • de grouchy syndrome
chromosome 18p deletion syndrome
  • 18p- syndrome
charcot-marie-tooth disease, type 1e
  • charcot-marie-tooth disease type 1
dejerine-sottas disease
  • dss
tyrosinemia, type ii
  • tyrosinemia type ii
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SULT2B1

Genetic Association Database (GAD)
SULT2B1
Human Genome Epidemiology (HuGE) Navigator
SULT2B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SULT2B1
genes like me logo Genes that share disorders with SULT2B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT2B1 Gene

Publications for SULT2B1 Gene

  1. Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene. (PMID: 9799594) Her C. … Weinshilboum R.M. (Genomics 1998) 2 3 4 23 67
  2. Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics. (PMID: 17496163) Ji Y. … Weinshilboum R.M. (J. Pharmacol. Exp. Ther. 2007) 3 23
  3. Identification and immunohistochemical localization of Sulfotransferase 2B1b (SULT2B1b) in human lung. (PMID: 15878639) He D. … Falany C.N. (Biochim. Biophys. Acta 2005) 3 23
  4. Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition. (PMID: 15953604) Lee Y.C. … Strott C.A. (FEBS Lett. 2005) 3 23
  5. Different subcellular localization of sulphotransferase 2B1b in human placenta and prostate. (PMID: 14741047) He D. … Falany C.N. (Biochem. J. 2004) 3 23

Products for SULT2B1 Gene

Sources for SULT2B1 Gene

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