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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SULT2B1 Gene

protein-coding   GIFtS: 69
GCID: GC19P049055

sulfotransferase family, cytosolic, 2B, member 1
 Explore 12 diseases affiliated with
SULT2B1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SULT2B1    

Aliases
for SULT2B1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sulfotransferase Family, Cytosolic, 2B, Member 11 2     ST2B12 3
HSST21 2 3     Sulfotransferase Family Cytosolic 2B Member 12
Alcohol Sulfotransferase2 3     EC 2.8.2.23
Hydroxysteroid Sulfotransferase 22 3     EC 2.8.28
Sulfotransferase 2B12 3     

External Ids:    HGNC: 114591   Entrez Gene: 68202   Ensembl: ENSG000000880027   OMIM: 6041255   UniProtKB: O002043   

Export aliases for SULT2B1 gene to outside databases

Previous GC identifers: GC19P049699 GC19P049423 GC19P053731 GC19P053747 GC19P045434


Summaries
for SULT2B1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SULT2B1:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic
compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene
structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but
not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively
spliced variants that encode different isoforms have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ST2B1_HUMAN, O00204
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the
water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to
form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and
isoform 2 avidly sulfonates pregnenolone but not cholesterol

Gene Wiki entry for SULT2B1


Genomic Views
for SULT2B1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SULT2B1 gene promoter:
         Egr-3   C/EBPbeta   Lmo2   AP-4   C/EBPalpha   RORalpha2   Nkx6-1   FOXO4   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SULT2B1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SULT2B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULT2B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

SULT2B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT2B1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049055:  view genomic region     (about GC identifiers)

Start:
 49,055,429 bp from pter      End:
 49,102,684 bp from pter
Size:
 47,256 bases      Orientation:
 plus strand

Proteins
for SULT2B1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ST2B1_HUMAN, O00204 (See protein sequence)
Recommended Name: Sulfotransferase family cytosolic 2B member 1  
Size: 365 amino acids; 41308 Da
Subcellular location: Cytoplasm. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation to
the nucleus
4 PDB 3D structures from and Proteopedia for SULT2B1:
1Q1Q (3D)        1Q1Z (3D)        1Q20 (3D)        1Q22 (3D)    
Secondary accessions: O00205 O75814
Alternative splicing: 2 isoforms:  O00204-1   O00204-2   

Explore the universe of human proteins at neXtProt for SULT2B1: NX_O00204

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00204

    • 2 DME Specific Peptides for SULT2B1 (O00204)
     PKSGTTW  GDWKNHFTVAQ 

    SULT2B1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_004596.2  NP_814444.1  

    ENSEMBL proteins: 
     ENSP00000201586   ENSP00000312880  
    Reactome Protein details: O00204
    Human Recombinant Protein Products: 
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    Novus Biologicals SULT2B1 Proteins
    Novus Biologicals SULT2B1 Lysates
    Sino Biological Recombinant Protein for SULT2B1
    ProSpec Recombinant Protein for SULT2B1
    Uscn Proteins for SULT2B1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS9799594
    GO:0005783endoplasmic reticulum IEA--
    GO:0005792microsome ----
    GO:0005829cytosol TAS--


    SULT2B1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SULT2B1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SULT2B1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry O00204

    ProtoNet protein and cluster: O00204

    1 Blocks protein family: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST2B1_HUMAN, O00204
    Similarity: Belongs to the sulfotransferase 1 family


    Function
    for SULT2B1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ST2B1_HUMAN, O00204
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the
    water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to
    form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and
    isoform 2 avidly sulfonates pregnenolone but not cholesterol
    Catalytic activity: 3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate
    Biophysicochemical properties: Kinetic parameters: KM=10.9 uM for DHEA (at 37 degrees Celsius, in the presence of 1mM
    MgCl2); KM=3.8 uM for DHEA (at 37 degrees Celsius, in the presence of 10mM MgCl2); KM=11.8 uM for pregnenolone (at 37
    degrees Celsius, in the presence of 1mM MgCl2); KM=0.6 uM for PAPS (at 37 degrees Celsius, in the presence of 1mM
    MgCl2); Vmax=1752 pmol/min/mg enzyme toward DHEA (at 37 degrees Celsius, in the presence of 10 mM MgCl2); Temperature
    dependence: Optimum temperature is 37 degrees Celsius. Retains 70% and 20% of activity when incubated at 42 degrees
    Celsius for 45 and 120 minutes, respectively. Activity is lost after 200 minutes incubation at 42 degrees Celsius;

         Genatlas biochemistry entry for SULT2B1:
    hydroxysteroid sulfotransferase,highly expressed in placenta,prostate,trachea,with two isoforms SULT2B1A and SULT2B1B

    Enzyme Numbers (IUBMB): EC 2.8.22 EC 2.8.2.21

    miRNA
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004027alcohol sulfotransferase activity TAS--
    GO:0005515protein binding IPI19060904
    GO:0008146sulfotransferase activity ----
    GO:0050294steroid sulfotransferase activity IDA12145317


    SULT2B1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Sult2b1tm1Rus for SULT2B1
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Sult2b1):
     homeostasis/metabolism 

    SULT2B1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SULT2B1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytosolic sulfonation of small molecules
    		Cytosolic sulfonation of small molecules1.00
    		Sulfur metabolism0.44
    		Sulfation Biotransformation Reaction0.67
    2Biological oxidations
    		Biological oxidations1.00
    		metapathway biotransformation0.41
    		Phase II conjugation0.52
    3Estrone metabolism
    		Estrone metabolism1.00
    		Estrone metabolism1.00
    4Metabolism
    		Metabolism1.00
    5Vitamin A and carotenoid metabolism
    		Vitamin A and carotenoid metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SULT2B1
        Estrone metabolism


    1 GeneGo (Thomson Reuters) Pathway for SULT2B1
        Estrone metabolism

    3 BioSystems Pathways for SULT2B1 
        Vitamin A and carotenoid metabolism
    Sulfation Biotransformation Reaction
    metapathway biotransformation

    4        Reactome Pathways for SULT2B1
        Metabolism
    Biological oxidations
    Cytosolic sulfonation of small molecules
    Phase II conjugation


    2         Kegg Pathways  (Kegg details for SULT2B1):
        Steroid hormone biosynthesis
    Sulfur metabolism


    SULT2B1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SULT2B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/26 Interacting proteins for SULT2B1 (O002041, 2, 3 ENSP000002015864) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SULT1E1P498882, 3, ENSP000002264444MINT-67530 I2D: score=5 STRING: ENSP00000226444
    ALS2CR12Q96Q352, 3, ENSP000002861904MINT-67791 I2D: score=3 STRING: ENSP00000286190
    -Q8N1B61, 3EBI-749441,EBI-750451 I2D: score=1 
    CYP11A1ENSP000002680534STRING: ENSP00000268053
    CYP17A1ENSP000003589034STRING: ENSP00000358903
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000103sulfate assimilation IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008202steroid metabolic process IDA12145317
    GO:0044281small molecule metabolic process TAS--
    GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process TAS--


    SULT2B1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SULT2B1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SULT2B1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SULT2B1

    10/12 HMDB Compounds for SULT2B1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Androsterone sulfate3alpha-Sulfate-5alpha-androstan-17-one (see all 8)2479-86-9--
    DHEA sulfate(3beta)-3-(sulfooxy)-Androst-5-en-17-one (see all 16)651-48-9--
    Dehydroepiandrosterone(+)-Dehydroisoandrosterone (see all 42)53-43-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--
    Isopropyl alcohol2-Propanol (see all 12)67-63-0--

    4 DrugBank Compounds for SULT2B1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dehydroepiandrosterone3-beta-Hydroxy-5-androsten-17-one (see all 6)53-43-0target--17139284 17016423 10592235
    Pregnenolone-- --target--17139284 17016423 10592235
    Adenosine-3'-5'-Diphosphate-- --target--17139284 17016423
    N-Cyclohexyltaurine-- --target--17139284 17016423

    4 Novoseek chemical compound relationships for SULT2B1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxysteroid 92.7 3 12145317 (1), 12923182 (1), 9799594 (1)
    cholesterol 47.4 3 12145317 (2), 15953604 (1)
    sterol 46.7 6 16368200 (3), 15953604 (1)
    steroid 37.2 5 15953604 (1), 16368200 (1), 19308726 (1)

    Search CenterWatch for drugs/clinical trials and news about SULT2B1 / ST2B1 

    Transcripts
    for SULT2B1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SULT2B1 gene (2 alternative transcripts): 
    NM_004605.2  NM_177973.1  

    Unigene Cluster for SULT2B1:

    Sulfotransferase family, cytosolic, 2B, member 1
    Hs.369331  [show with all ESTs]
    Unigene Representative Sequence: U92314
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000201586(uc002pjl.3) ENST00000323090(uc002pjm.3)

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    Clone
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    Additional cDNA sequence: 

    BC034694.1 U92314.1 U92315.1 

    5 DOTS entries:

    DT.211063  DT.100754391  DT.99935825  DT.121504405  DT.92425852 

    6 AceView cDNA sequences:

    BC034694 NM_004605 NM_177973 U92314 AK096418 U92315 

    GeneLoc Exon Structure


    Expression
    for SULT2B1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SULT2B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCAACTACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SULT2B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SULT2B1

    SOURCE GeneReport for Unigene cluster: Hs.369331

    UniProtKB/Swiss-Prot: ST2B1_HUMAN, O00204
    Tissue specificity: Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and
    lung

        SABiosciences Expression via Pathway-Focused PCR Array including SULT2B1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for SULT2B1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SULT2B1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sult2b11 , 5 sulfotransferase family, cytosolic, 2B, member 11, 5 77.84(n)1
    76.56(a)1    		   7 (29.47 cM)5
    542001  NM_017465.21  NP_059493.21 
     457299835 
    chicken
    (Gallus gallus)    		 Aves LOC7698411 sulfotransferase family cytosolic 2B member 1-like 61.26(n)
    52.76(a)    		   769841  XM_001233157.2  XP_001233158.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SULT2B16
    --
    (see all 3)    		 --
    		 56(a)
    54(a)
    (see all 3)    		 possible ortholog
    1 ↔ 1
    (see all 3)    		 GL343279.1(995519-1006491)
    GL343253.1(1585628-1592226)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.239022 Xenopus laevis transcribed sequence with weak similarity more 74.9(n)    CB565072.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.252392 Transcribed sequence with weak similarity to protein more 77.25(n)    CD014631.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SOT76
    AT2G037706
    (see all 17)    		 sulfotransferase 7
    P-loop containing nucleoside triphosphate hydrolas...
    (see all 17)    		 20(a)
    20(a)
    (see all 17)    		 many ↔ many
    many ↔ many
    (see all 17)    		 1(9841332-9842312)
    2(1150871-1151845)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 30)    		 sulfotransferase domain containing protein
    (see all 30)    		 24(a)
    24(a)
    (see all 30)    		 many ↔ many
    many ↔ many
    (see all 30)    		 8(10722317-10723670)
    12(1821392-1822197)


    ENSEMBL Gene Tree for SULT2B1 (if available)
    TreeFam Gene Tree for SULT2B1 (if available) 

    Paralogs
    for SULT2B1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SULT2B1 gene
    SULT1C32  SULT4A12  SULT1B12  SULT1C42  SULT1A22  SULT1C22  SULT1E12  SULT1A42  
    SULT2A12  SULT6B12  SULT1A12  SULT1A32  
    12 SIMAP similar genes for SULT2B1 using alignment to 1 protein entry:     ST2B1_HUMAN:
    SULT2A1    SULT1C4    SULT1A1    SULT1E1    SULT1C2    ST1A5
    SULT1A2    SULT1A3    SULT1A4    SULT1B1    SULT1C3    SULT6B1

    SULT2B1 for paralogs           About GeneDecksing



    Genomic Variants
    for SULT2B1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1194 NCBI SNPs in SULT2B1 are shown (see all 1194)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2794501,2
    		C,H,--49053500(-) TAAAAG/AGGCTC 1 -- us2k112Minor allele frequency- A:0.02NA WA CSA EA 378
    rs1862783701,2
    		--49053695(+) GAAGGC/TGGGCA 1 -- us2k10--------
    rs1145902511,2
    		C,F,--49053778(+) GTCTTC/TCATCC 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1415483381,2
    		--49053890(+) GCTGGA/CGTGCA 1 -- us2k10--------
    rs1505344021,2
    		--49053914(+) GGCTCA/GCTGCA 1 -- us2k10--------
    rs1395216801,2
    		--49053944(+) AAGTGA/GTTCTC 1 -- us2k10--------
    rs1441531281,2
    		--49053980(+) GATTAC/TAGGCA 1 -- us2k10--------
    rs1121912881,2
    		C,--49053981(+) ATTACG/AGGCAC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1918945311,2
    		--49054052(+) GCCAGC/GCTGGT 1 -- us2k10--------
    rs118786851,2
    		C,H,--49054079(+) caggcA/Gattca 1 -- us2k11Minor allele frequency- G:0.00NA 2

    HapMap Linkage Disequilibrium report for SULT2B1 (49055429 - 49102684 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SULT2B1
         3 CNVs: 10563 5958 32261
    Human Gene Mutation Database (HGMD): SULT2B1

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    Disorders / Diseases
    for SULT2B1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SULT2B1 for disorders           About GeneDecksing

    OMIM gene information: 604125    OMIM disorders: --

    12 diseases for SULT2B1:    About MalaCards
    variegate porphyria    porphyria    intellectual disability    alcoholism
    down syndrome    hepatitis c    prostate cancer    breast cancer
    hepatitis    cholesterol    prostatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SULT2B1:
    Variegate porphyria
    Genetic Association Database (GAD): SULT2B1
    Human Genome Epidemiology (HuGE) Navigator: SULT2B1 (4 documents)

    Export disorders for SULT2B1 gene to outside databases

    Publications
    for SULT2B1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SULT2B1 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with SULT2B1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene. (PubMed id 9799594)1, 2, 3, 9 Her C.... Weinshilboum R.M. (1998)
    2. Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase. (PubMed id 12145317)1, 2, 9 Fuda H.... Strott C.A. (2002)
    3. Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms. (PubMed id 12923182)1, 2, 9 Lee K.A.... Pedersen L.C. (2003)
    4. Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)1, 4 Saito T....Kawata S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    7. Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b). (PubMed id 11457664)1, 9 Meloche C.A. and Falany C.N. (2001)
    8. Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics. (PubMed id 17496163)1, 9 Ji Y....Weinshilboum R.M. (2007)
    9. Different subcellular localization of sulphotransferase 2B1b in human placenta and prostate. (PubMed id 14741047)1, 9 He D....Falany C.N. (2004)
    10. Identification and immunohistochemical localization of Sulfotransferase 2B1b (SULT2B1b) in human lung. (PubMed id 15878639)1, 9 He D....Falany C.N. (2005)

    External Searches for SULT2B1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    Genome Databases showing SULT2B1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6820 HGNC: 11459 AceView: SULT2B1 Ensembl:ENSG00000088002 euGenes: HUgn6820
    ECgene: SULT2B1 Kegg: 6820 H-InvDB: SULT2B1

    Other Databases showing SULT2B1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SULT2B1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SULT2B1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SULT2B1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SULT2B1 gene:
    Search GeneIP for patents involving SULT2B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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