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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SULT2A1 Gene

protein-coding   GIFtS: 66
GCID: GC19M048373

sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone...


(Previous symbol: STD)
 Explore 41 diseases affiliated with
SULT2A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SULT2A1    

Aliases
for SULT2A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sulfotransferase Family, Cytosolic, 2A, Dehydroepiandrosterone
(DHEA)-Preferring, Member 11 2
     Alcohol/Hydroxysteroid Sulfotransferase2
STD1 2 3 5     Bile Salt Sulfotransferase2
DHEA-ST1 2 3     Bile-Salt Sulfotranasferase 2A12
HST2 3     HSTa1
ST22 3     EC 2.8.2.143
ST2A12 3     Dehydroepiandrosterone Sulfotransferase3
ST2A32 3     Hydroxysteroid Sulfotransferase3
DHEAS2     Sulfotransferase 2A13

External Ids:    HGNC: 114581   Entrez Gene: 68222   Ensembl: ENSG000001053987   OMIM: 1252635   UniProtKB: Q065203   

Export aliases for SULT2A1 gene to outside databases

Previous GC identifers: GC19M049020 GC19M048765 GC19M053049 GC19M053065 GC19M044800


Summaries
for SULT2A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SULT2A1:
This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and
endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be
easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and
may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. (provided by RefSeq,
Mar 2010)

UniProtKB/Swiss-Prot: ST2A1_HUMAN, Q06520
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfonation of steroids and bile acids in the liver and adrenal glands

Gene Wiki entry for SULT2A1 (Bile salt sulfotransferase)


Genomic Views
for SULT2A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SULT2A1 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SULT2A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SULT2A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULT2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

SULT2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT2A1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M048373:  view genomic region     (about GC identifiers)

Start:
 48,373,723 bp from pter      End:
 48,389,654 bp from pter
Size:
 15,932 bases      Orientation:
 minus strand

Proteins
for SULT2A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ST2A1_HUMAN, Q06520 (See protein sequence)
Recommended Name: Bile salt sulfotransferase  
Size: 285 amino acids; 33780 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
Miscellaneous: Estrogens present in maternal circulation is predominantly derived from fetal dehydroepiandosterone
sulfate which is hydrolyzed and metabolized to estrogens in placenta
6/7 PDB 3D structures from and Proteopedia for SULT2A1 (see all 7):
1EFH (3D)        1J99 (3D)        1OV4 (3D)        2QP3 (3D)        2QP4 (3D)        3F3Y (3D)    

Explore the universe of human proteins at neXtProt for SULT2A1: NX_Q06520

Post-translational modifications:

  • The N-terminus is blocked1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q06520

    • SULT2A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003158.2  
    ENSEMBL proteins: 
     ENSP00000222002  
    Reactome Protein details: Q06520
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for SULT2A1 (Cytosolic Sulfotransferase 2A1/SULT2A1)
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    Novus Biologicals SULT2A1 Proteins
    Novus Biologicals SULT2A1 Lysate
    Sino Biological Recombinant Protein for SULT2A1
    ProSpec Recombinant Protein for SULT2A1
    Uscn Proteins for SULT2A1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    SULT2A1 for ontologies           About GeneDecksing



    SULT2A1 Antibody Products: 
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    Uscn ELISAs and CLIAs for SULT2A1

    Protein Domains /
    Families
    for SULT2A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SULT2A1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry Q06520

    ProtoNet protein and cluster: Q06520

    1 Blocks protein family: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST2A1_HUMAN, Q06520
    Similarity: Belongs to the sulfotransferase 1 family


    Function
    for SULT2A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ST2A1_HUMAN, Q06520
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    sulfonation of steroids and bile acids in the liver and adrenal glands
    Catalytic activity: 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate
    3-sulfate
    Catalytic activity: 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate
    sulfate

         Genatlas biochemistry entry for SULT2A1:
    hydroxysteroid dehydroepiandrosterone (DHEA) sulfotransferase,cytosolic,involved in the fine control of target cell
    sensitivity to hormone action,catalyzing the formation of DHEA-S,a major adrenal steroid,precursor for androgen and
    estrogen biosynthesis in peripheral tissues

    Enzyme Number (IUBMB): EC 2.8.2.141

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: SULT2A1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SULT2A1
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    Gene Editing
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    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SULT2A1 (NM_003167)
    Sino Biological Human cDNA Clone for SULT2A1
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    Cell Line
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    Search LifeMap BioReagents cell lines for SULT2A1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008146sulfotransferase activity TAS--
    GO:0047704bile-salt sulfotransferase activity IEA--


    SULT2A1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SULT2A1:
     Increased S DNA content 


    Pathways & Interactions
    for SULT2A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Tamoxifen metabolism
    		Tamoxifen metabolism1.00
    		Estradiol metabolism0.52
    		Tamoxifen Pathway, Pharmacokinetics0.68
    		Estradiol metabolism0.52
    2Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    		PPARA Activates Gene Expression0.74
    3Biological oxidations
    		Biological oxidations1.00
    		metapathway biotransformation0.41
    		Phase II conjugation0.52
    4Cytosolic sulfonation of small molecules
    		Cytosolic sulfonation of small molecules1.00
    		Sulfation Biotransformation Reaction0.67
    5Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for SULT2A1
        Androstenedione and testosterone biosynthesis and metabolism p.1
    Estradiol metabolism


    2 GeneGo (Thomson Reuters) Pathways for SULT2A1
        Estradiol metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.1

    5 BioSystems Pathways for SULT2A1 
        Sulfation Biotransformation Reaction
    Tamoxifen metabolism
    Drug Induction of Bile Acid Pathway
    E2F transcription factor network
    metapathway biotransformation

    5/9        Reactome Pathways for SULT2A1 (see all 9)
        Metabolism
    Cytosolic sulfonation of small molecules
    Expression of SULT2A1
    Fatty acid, triacylglycerol, and ketone body metabolism
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

    4 PharmGKB Pathways for SULT2A1
        Acetaminophen Pathway, Pharmacokinetics
    Estrogen Metabolism Pathway
    Pathway_PA165986194 -need delete
    Tamoxifen Pathway, Pharmacokinetics

    1         Kegg Pathway  (Kegg details for SULT2A1):
        Bile secretion


    SULT2A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SULT2A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for SULT2A1 (Q065201 ENSP000002220024) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT3P407631, ENSP000002646574EBI-3921363,EBI-518675 STRING: ENSP00000264657
    CARM1ENSP000003256904STRING: ENSP00000325690
    PPARAENSP000002627354STRING: ENSP00000262735
    RXRAENSP000004196924STRING: ENSP00000419692
    BPNT1ENSP000003188524STRING: ENSP00000318852
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007586digestion NAS1588921
    GO:0008202steroid metabolic process TAS1588921
    GO:0030573bile acid catabolic process IEA--
    GO:0044255cellular lipid metabolic process TAS--


    SULT2A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SULT2A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SULT2A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SULT2A1

    6 HMDB Compounds for SULT2A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Androsterone(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one (see all 28)53-41-814573603
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Androsterone sulfate3alpha-Sulfate-5alpha-androstan-17-one (see all 8)2479-86-9--
    DHEA sulfate(3beta)-3-(sulfooxy)-Androst-5-en-17-one (see all 16)651-48-9--
    Dehydroepiandrosterone(+)-Dehydroisoandrosterone (see all 42)53-43-0--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--

    4 DrugBank Compounds for SULT2A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aetiocholanolone-- 53-42-9target--17139284 17016423 10592235
    Dehydroepiandrosterone3-beta-Hydroxy-5-androsten-17-one (see all 6)53-43-0target--17139284 17016423 10592235
    Adenosine-3'-5'-Diphosphate-- --target--17139284 17016423
    Mercury Diiodide-- --target--17139284 17016423

    10/40 Novoseek chemical compound relationships for SULT2A1 gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxysteroid 97.5 110 9806149 (3), 15371299 (3), 7589232 (3), 15644508 (3) (see all 61)
    dhea 93.1 279 9010352 (12), 8971138 (11), 1355717 (6), 8222492 (6) (see all 83)
    alpha-hydroxytamoxifen 91.2 8 9806149 (3), 9855017 (1), 11358807 (1), 12419845 (1)
    1-hydroxyethylpyrene 89.9 2 9636676 (1), 7589232 (1)
    2,6-dichloro-4-nitrophenol 86.4 4 7859374 (1), 8097696 (1)
    3-phosphoadenosine 5'-phosphosulfate 83.9 11 15483193 (1), 16099924 (1), 14573603 (1), 15198932 (1) (see all 5)
    dehydroepiandrosterone sulfate 82.9 24 17426092 (3), 15084485 (2), 8751327 (1), 7859374 (1) (see all 16)
    3'-phosphoadenosine 5'-phosphate 78.7 2 7697798 (1)
    phenol 74.8 50 8563037 (2), 1355717 (2), 7589232 (2), 10503886 (1) (see all 21)
    3beta-hydroxysteroid 71.7 9 11155097 (1), 11744071 (1), 12589943 (1), 15878968 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about SULT2A1 / ST2A1 

    Transcripts
    for SULT2A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SULT2A1 gene: 
    NM_003167.3  

    Unigene Cluster for SULT2A1:

    Sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
    Hs.515835  [show with all ESTs]
    Unigene Representative Sequence: NM_003167
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000222002(uc002phr.2)

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK289380.1 AK313415.1 BC020755.1 L02337.1 L20000.1 S43859.1 S43861.1 U08024.1 
    U08025.1 X70222.1 X84816.1 

    5 DOTS entries:

    DT.314614  DT.100773398  DT.92424924  DT.100773401  DT.95257375 

    24/67 AceView cDNA sequences (see all 67):

    CR608228 BX509439 C21053 BQ013785 AI382378 AI028152 CB157413 AA446955 
    CB117004 S43859 T28260 AV705351 AA328456 BG563083 AA443380 AV655396 
    CB163674 U08024 CB162380 BX509490 U08025 BG616732 L02337 AI151302 

    GeneLoc Exon Structure


    Expression
    for SULT2A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SULT2A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGATCCCAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SULT2A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SULT2A1

    SOURCE GeneReport for Unigene cluster: Hs.515835

    UniProtKB/Swiss-Prot: ST2A1_HUMAN, Q06520
    Tissue specificity: Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the
    adrenal than the liver and the kidney

        SABiosciences Expression via Pathway-Focused PCR Array including SULT2A1: 
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    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT2A1

    Orthologs
    for SULT2A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SULT2A1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 47(a)
    44(a)
    (see all 3)    		 1 ↔ many
    possible ortholog
    (see all 3)    		 GL343281.1(1090630-1103259)
    GL343279.1(1042027-1050181)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.67112 Transcribed sequence with weak similarity to protein more 74.48(n)    BQ527455.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ST16
    AT2G037706
    (see all 17)    		 flavonol sulfotransferase-like protein
    P-loop containing nucleoside triphosphate hydrolas...
    (see all 17)    		 23(a)
    23(a)
    (see all 17)    		 many ↔ many
    many ↔ many
    (see all 17)    		 2(1149337-1150663)
    2(1150871-1151845)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 30)    		 sulfotransferase domain containing protein
    (see all 30)    		 27(a)
    25(a)
    (see all 30)    		 many ↔ many
    many ↔ many
    (see all 30)    		 8(10722317-10723670)
    7(24900928-24902268)


    ENSEMBL Gene Tree for SULT2A1 (if available)
    TreeFam Gene Tree for SULT2A1 (if available) 

    Paralogs
    for SULT2A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SULT2A1 gene
    SULT1C32  SULT4A12  SULT1B12  SULT1C42  SULT1A22  SULT1C22  SULT1E12  SULT2B12  
    SULT1A42  SULT6B12  SULT1A12  SULT1A32  
    13 SIMAP similar genes for SULT2A1 using alignment to 2 protein entries:     ST2A1_HUMAN (see all proteins):
    SULT2B1    SULT1A1    SULT1A2    SULT1A3    SULT1A4    SULT1C4
    ST1A5    SULT1C2    SULT1B1    SULT1C3    SULT1E1    SULT6B1
    SULT4A1

    SULT2A1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SULT2A1
    PGOHUM00000234440 PGOHUM00000234802


    Genomic Variants
    for SULT2A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/389 NCBI SNPs in SULT2A1 are shown (see all 389)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs11314051,2
    		C,F,--44800914(-) CCAGCC/GTGGGT 1 -- ut318Minor allele frequency- G:0.03NS NA CSA 188
    rs625298861,2
    		C,F,--44800982(-) TGAGGT/CAGGAG 1 -- ut315Minor allele frequency- C:0.05NS 180
    rs625298841,2
    		C,--44801015(-) GTGCAC/TGCCTA 1 -- ut315Minor allele frequency- T:0.01NS 180
    rs1124684111,2
    		C,--44801075(+) ATGTTG/AGCCAG 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs1122850021,2
    		C,--44801089(+) GGTCTC/TGATCT 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs625298831,2
    		C,F,--44801164(-) CAGGCG/ACATTG 1 -- ut315Minor allele frequency- A:0.02NS 184
    rs625298821,2
    		C,F,--44801217(-) AACACG/AGTGAA 1 -- ut315Minor allele frequency- A:0.05NS 186
    rs104169941,2
    		C--44801224(+) tgttaG/Accagg 1 -- ut31 ese35Minor allele frequency- A:0.00NS 186
    rs625298811,2
    		C,F,--44801276(-) CACTAT/GGGGAG 1 -- ut315Minor allele frequency- G:0.02NS 186
    rs625298801,2
    		F,--44801401(-) TCATTG/ATGTAA 1 -- ut315Minor allele frequency- A:0.01NS 188

    HapMap Linkage Disequilibrium report for SULT2A1 (48373723 - 48389654 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SULT2A1: --
    Human Gene Mutation Database (HGMD): SULT2A1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SULT2A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SULT2A1

    Disorders / Diseases
    for SULT2A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SULT2A1 for disorders           About GeneDecksing

    OMIM gene information: 125263    OMIM disorders: --

    20/41 diseases for SULT2A1 (see all 41):    About MalaCards
    polycystic ovary syndrome    x-linked ichthyosis    polymyalgia rheumatica    precocious puberty
    adrenal hyperplasia    thyroid hormone metabolism    cushing's syndrome    ichthyosis
    adrenal adenoma    anovulation    cholangitis    virilization
    insulin resistance    amenorrhea    hyperinsulinism    liver disease
    alcoholism    hyperandrogenism    adenoma    hepatocellular carcinoma

    11 diseases from the University of Copenhagen DISEASES database for SULT2A1:
    Polycystic ovary syndrome     Hyperandrogenism     Anovulation     Amenorrhea
    Hyperinsulinism     X-linked ichthyosis     Infertility     Cushing's syndrome
    Osteoporosis     Hypogonadism     Adrenal adenoma

    10/12 Novoseek disease relationships for SULT2A1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenoma adrenocortical 63.7 1 8751327 (1)
    cushing syndrome 29.7 4 8930526 (2), 11456263 (1)
    carcinoma adrenocortical 29.5 1 8751327 (1)
    cholangitis primary sclerosing 19.9 1 10726960 (1)
    breast cancer 16.9 2 19308726 (1)
    hepatocellular carcinoma 14.4 4 15667595 (1), 15713538 (1)
    atrophy 0 2 14567506 (1), 17318025 (1)
    liver diseases 0 1 10726960 (1)
    adenoma 0 10 8751327 (3), 17408424 (1)
    tumors 0 8 11456263 (1), 15713538 (1), 1419884 (1), 17318025 (1)

    Human Genome Epidemiology (HuGE) Navigator: SULT2A1 (6 documents)

    Export disorders for SULT2A1 gene to outside databases

    Publications
    for SULT2A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SULT2A1 gene, integrated from 9 sources (see all 179):
    (articles sorted by number of sources associating them with SULT2A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. (PubMed id 14573603)1, 2, 6, 9 Chang H.J.... Lin S.X. (2004)
    2. Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA. (PubMed id 1588921)1, 2, 3 Otterness D.M.... Weinshilboum R.M. (1992)
    3. Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization. (PubMed id 7710689)1, 2, 9 Otterness D.M....Weinshilboum R.M. (1995)
    4. Cloning and expression of human liver dehydroepiandrosterone sulphotransferase. (PubMed id 7678732)1, 2, 9 Comer K.A.... Falany C.N. (1993)
    5. Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3. (PubMed id 7736787)1, 3, 9 Otterness D.M....Weinshilboum R.M. (1995)
    6. Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme. (PubMed id 7589785)1, 2, 9 Forbes K.J.... Hume R. (1995)
    7. Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate. (PubMed id 11988089)1, 2, 9 Rehse P.H.... Lin S.X. (2002)
    8. Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase. (PubMed id 10854859)1, 2, 9 Pedersen L.C.... Negishi M. (2000)
    9. Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene. (PubMed id 7598806)1, 2, 9 Luu-The V.... Labrie F. (1995)
    10. Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver. (PubMed id 1520333)1, 2, 9 Kong A.-N.T.... Bjornsson T.D. (1992)

    External Searches for SULT2A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SULT2A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6822 HGNC: 11458 AceView: SULT2A1 Ensembl:ENSG00000105398 euGenes: HUgn6822
    ECgene: SULT2A1 Kegg: 6822 H-InvDB: SULT2A1

    Other Databases showing SULT2A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SULT2A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SULT2A1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SULT2A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SULT2A1 gene:
    Search GeneIP for patents involving SULT2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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