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Aliases for SULT2A1 Gene

Aliases for SULT2A1 Gene

  • Sulfotransferase Family 2A Member 1 2 3 5
  • Sulfotransferase Family, Cytosolic, 2A, Dehydroepiandrosterone (DHEA)-Preferring, Member 1 2 3
  • DHEA-ST 3 4
  • ST2A1 3 4
  • ST2A3 3 4
  • HST 3 4
  • ST2 3 4
  • STD 3 4
  • Alcohol/Hydroxysteroid Sulfotransferase 3
  • Dehydroepiandrosterone Sulfotransferase 4
  • Bile-Salt Sulfotranasferase 2A1 3
  • Hydroxysteroid Sulfotransferase 4
  • Bile Salt Sulfotransferase 3
  • Sulfotransferase 2A1 4
  • EC 2.8.2.14 4
  • DHEAS 3
  • HSTa 3

External Ids for SULT2A1 Gene

Previous HGNC Symbols for SULT2A1 Gene

  • STD

Previous GeneCards Identifiers for SULT2A1 Gene

  • GC19M049020
  • GC19M048765
  • GC19M053049
  • GC19M053065
  • GC19M048373
  • GC19M044800

Summaries for SULT2A1 Gene

Entrez Gene Summary for SULT2A1 Gene

  • This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]

GeneCards Summary for SULT2A1 Gene

SULT2A1 (Sulfotransferase Family 2A Member 1) is a Protein Coding gene. Diseases associated with SULT2A1 include Sex Differentiation Disease and Adrenal Cortical Adenoma. Among its related pathways are Estrogen metabolism and Acetaminophen Pathway (therapeutic doses), Pharmacokinetics. GO annotations related to this gene include sulfotransferase activity and bile-salt sulfotransferase activity. An important paralog of this gene is SULT2B1.

UniProtKB/Swiss-Prot for SULT2A1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.

Gene Wiki entry for SULT2A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT2A1 Gene

Genomics for SULT2A1 Gene

Regulatory Elements for SULT2A1 Gene

Enhancers for SULT2A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G047657 1.7 Ensembl ENCODE dbSUPER 10.3 +223.1 223134 10.6 MLX CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D BICRA NOP53 ZNF541 SNORD23 SULT2A1 ENSG00000278999 BICRA-AS1
GH19G047963 0.8 ENCODE 10.5 -77.0 -76952 0.2 PKNOX1 ZNF2 RAD21 ZEB1 ZNF335 GATA2 SCRT2 ZNF143 MIXL1 ZNF654 BSPH1 PLA2G4C ELSPBP1 CABP5 SULT2A1 LMTK3 SYNGR4 TMEM143 SNAR-C1 GC19M047959
GH19G047509 1.8 FANTOM5 ENCODE dbSUPER 4.5 +373.5 373455 7.1 HDGF HNRNPUL1 PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A ZNF2 KPTN NAPA CCDC9 C5AR1 DHX34 LIG1 SULT2A1 BICRA ZC3H4 C5AR2
GH19G048091 0.6 ENCODE 9.8 -205.1 -205142 0.2 NR2F1 BHLHE40 ZNF121 JUND ZFHX2 POLR3A FOS TCF7L2 CABP5 BSPH1 ELSPBP1 NAPA SULT2A1 LMTK3 PLA2G4C PLA2G4C-AS1
GH19G047799 0.5 FANTOM5 11.6 +87.3 87307 0.2 ZNF366 YBX1 ZBTB17 CRX SNORD23 NOP53 SULT2A1 CABP5 RPL23AP80 TPRX1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SULT2A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SULT2A1 Gene

Chromosome:
19
Start:
47,870,466 bp from pter
End:
47,886,397 bp from pter
Size:
15,932 bases
Orientation:
Minus strand

Genomic View for SULT2A1 Gene

Genes around SULT2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT2A1 Gene

Proteins for SULT2A1 Gene

  • Protein details for SULT2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06520-ST2A1_HUMAN
    Recommended name:
    Bile salt sulfotransferase
    Protein Accession:
    Q06520

    Protein attributes for SULT2A1 Gene

    Size:
    285 amino acids
    Molecular mass:
    33780 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Estrogens present in maternal circulation is predominantly derived from fetal dehydroepiandosterone sulfate which is hydrolyzed and metabolized to estrogens in placenta.

    Three dimensional structures from OCA and Proteopedia for SULT2A1 Gene

neXtProt entry for SULT2A1 Gene

Post-translational modifications for SULT2A1 Gene

Other Protein References for SULT2A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SULT2A1 (Cytosolic Sulfotransferase 2A1/SULT2A1)

No data available for DME Specific Peptides for SULT2A1 Gene

Domains & Families for SULT2A1 Gene

Gene Families for SULT2A1 Gene

Protein Domains for SULT2A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q06520

UniProtKB/Swiss-Prot:

ST2A1_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT2A1: view

Function for SULT2A1 Gene

Molecular function for SULT2A1 Gene

GENATLAS Biochemistry:
hydroxysteroid dehydroepiandrosterone (DHEA) sulfotransferase,cytosolic,involved in the fine control of target cell sensitivity to hormone action,catalyzing the formation of DHEA-S,a major adrenal steroid,precursor for androgen and estrogen biosynthesis in peripheral tissues
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + glycolithocholate = adenosine 3,5-bisphosphate + glycolithocholate 3-sulfate.
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + taurolithocholate = adenosine 3,5-bisphosphate + taurolithocholate sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.

Enzyme Numbers (IUBMB) for SULT2A1 Gene

Gene Ontology (GO) - Molecular Function for SULT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity TAS --
GO:0004304 estrone sulfotransferase activity TAS --
GO:0005515 protein binding IPI 21988832
GO:0008146 sulfotransferase activity TAS,IDA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SULT2A1: view
genes like me logo Genes that share phenotypes with SULT2A1: view

Animal Model Products

CRISPR Products

miRNA for SULT2A1 Gene

miRTarBase miRNAs that target SULT2A1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SULT2A1 Gene

Localization for SULT2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT2A1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT2A1 gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2
peroxisome 2
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SULT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT2A1: view

Pathways & Interactions for SULT2A1 Gene

genes like me logo Genes that share pathways with SULT2A1: view

Gene Ontology (GO) - Biological Process for SULT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006068 ethanol catabolic process IDA 23207770
GO:0006629 lipid metabolic process IEA --
GO:0007586 digestion NAS 1588921
GO:0008202 steroid metabolic process IDA,TAS 23207770
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with SULT2A1: view

No data available for SIGNOR curated interactions for SULT2A1 Gene

Drugs & Compounds for SULT2A1 Gene

(31) Drugs for SULT2A1 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abiraterone Approved Pharma Enzyme, substrate Potent CYP17 inhibitor 0
Acetaminophen Approved Pharma Enzyme, substrate Cyclooxygenase inhibitor; may be selective for COX-3 1026
Dehydroepiandrosterone Approved Nutra Target 95
Palbociclib Approved Pharma 127
Zytiga Approved May 2011 Pharma 0

(26) Additional Compounds for SULT2A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
7-Hydroxymethyl-12-methylbenz[a]anthracene
7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Androsterone
  • (3alpha,5alpha)-3-hydroxy-Androstan-17-one
  • (3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one
  • 3-alpha-Hydroxy-17-androstanone
  • 3-alpha-Hydroxy-5-alpha-androstan-17-one
  • 3-alpha-Hydroxy-5-alpha-androstane-17-one
53-41-8
Lithocholic acid glycine conjugate
  • 3a-Hydroxy-5b-cholanic acid glycine ester
  • 3a-Hydroxy-5b-cholanoylglycine
  • 3a-Hydroxy-N-(carboxymethyl)-5b-cholan-24-amide
  • 3alpha-hydroxy-5beta-cholan-24-oate
  • 3alpha-hydroxy-5beta-cholan-24-oic acid
474-74-8
genes like me logo Genes that share compounds with SULT2A1: view

Transcripts for SULT2A1 Gene

mRNA/cDNA for SULT2A1 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(67) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT2A1 Gene

Sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULT2A1 Gene

No ASD Table

Relevant External Links for SULT2A1 Gene

GeneLoc Exon Structure for
SULT2A1
ECgene alternative splicing isoforms for
SULT2A1

Expression for SULT2A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SULT2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT2A1 Gene

This gene is overexpressed in Liver (x38.0) and Adrenal Gland (x13.4).

Protein differential expression in normal tissues from HIPED for SULT2A1 Gene

This gene is overexpressed in Liver, secretome (19.8), Gallbladder (18.8), Liver (15.2), and Adrenal (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SULT2A1 Gene



Protein tissue co-expression partners for SULT2A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SULT2A1 Gene:

SULT2A1

SOURCE GeneReport for Unigene cluster for SULT2A1 Gene:

Hs.515835

mRNA Expression by UniProt/SwissProt for SULT2A1 Gene:

Q06520-ST2A1_HUMAN
Tissue specificity: Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.

Evidence on tissue expression from TISSUES for SULT2A1 Gene

  • Adrenal gland(4.8)
  • Liver(4.7)
  • Blood(2.6)
  • Nervous system(2.6)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with SULT2A1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT2A1 Gene

Orthologs for SULT2A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT2A1 34 35
  • 98.21 (n)
cow
(Bos Taurus)
Mammalia SULT2A1 34 35
  • 78.01 (n)
-- 35
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sult2a1 34
  • 72.34 (n)
mouse
(Mus musculus)
Mammalia Sult2a1 34 35
  • 72.28 (n)
Sult2a6 16 35
  • 64 (a)
Sult2a3 35
  • 63 (a)
OneToMany
Sult2a4 35
  • 63 (a)
OneToMany
Sult2a5 35
  • 63 (a)
OneToMany
2810007J24Rik 35
  • 60 (a)
OneToMany
Sult2a7 35
  • 59 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SULT2A1 35
  • 47 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 37 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 29 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sult2a1 34
  • 58.1 (n)
Str.6711 34
zebrafish
(Danio rerio)
Actinopterygii sult2st1 35 35
  • 40 (a)
ManyToMany
sult2st2 35
  • 39 (a)
ManyToMany
sult2st3 35
  • 38 (a)
ManyToMany
si:dkey-236e20.3 35
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y113G7A.11 36
  • 32 (a)
Species where no ortholog for SULT2A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SULT2A1 Gene

ENSEMBL:
Gene Tree for SULT2A1 (if available)
TreeFam:
Gene Tree for SULT2A1 (if available)

Paralogs for SULT2A1 Gene

(13) SIMAP similar genes for SULT2A1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SULT2A1 Gene

genes like me logo Genes that share paralogs with SULT2A1: view

Variants for SULT2A1 Gene

Sequence variations from dbSNP and Humsavar for SULT2A1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000045453 -- 47,883,203(+) TTTCT(A/G)TGGCA intron-variant
rs1000404199 -- 47,878,037(+) CACTT(C/T)TACCC intron-variant
rs1000780722 -- 47,872,658(+) TCATA(-/AC)ACATA intron-variant
rs1000823724 -- 47,876,546(+) AAAGG(C/G/T)CTTCT intron-variant
rs1001131665 -- 47,887,902(+) CGGTG(C/T)GGTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SULT2A1 Gene

Variant ID Type Subtype PubMed ID
esv1006582 CNV insertion 20482838
esv2676204 CNV deletion 23128226
esv2718669 CNV deletion 23290073
esv3556495 CNV deletion 23714750
esv3644559 CNV gain 21293372
esv3644566 CNV loss 21293372
esv3644567 CNV loss 21293372
esv3644568 CNV gain 21293372
esv3893227 CNV loss 25118596
nsv1056164 CNV gain 25217958
nsv1058622 CNV gain 25217958
nsv1066097 CNV gain 25217958
nsv1066782 CNV loss 25217958
nsv1114020 CNV deletion 24896259
nsv2513 CNV deletion 18451855
nsv428367 CNV gain+loss 18775914
nsv458715 CNV gain 19166990
nsv509748 CNV insertion 20534489
nsv523319 CNV loss 19592680
nsv579897 CNV gain 21841781
nsv579898 CNV loss 21841781
nsv579899 CNV loss 21841781
nsv828571 CNV loss 20364138

Variation tolerance for SULT2A1 Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULT2A1 Gene

Human Gene Mutation Database (HGMD)
SULT2A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT2A1 Gene

Disorders for SULT2A1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SULT2A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sex differentiation disease
  • disorder of sexual differentiation
adrenal cortical adenoma
  • adrenocortical adenoma
polycystic ovary syndrome
  • multicystic ovaries
adrenal adenoma
  • adrenal cortical adenoma
sebaceous gland disease
  • sebaceous gland diseases
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SULT2A1

Genetic Association Database (GAD)
SULT2A1
Human Genome Epidemiology (HuGE) Navigator
SULT2A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SULT2A1
genes like me logo Genes that share disorders with SULT2A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT2A1 Gene

Publications for SULT2A1 Gene

  1. Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. (PMID: 14573603) Chang H.J. … Lin S.X. (J. Biol. Chem. 2004) 3 4 22 25 64
  2. Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome. (PMID: 17426092) Goodarzi M.O. … Azziz R. (J. Clin. Endocrinol. Metab. 2007) 3 22 46 64
  3. Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate. (PMID: 11988089) Rehse P.H. … Lin S.X. (Biochem. J. 2002) 3 4 22 64
  4. Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase. (PMID: 10854859) Pedersen L.C. … Negishi M. (FEBS Lett. 2000) 3 4 22 64
  5. Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene. (PMID: 7598806) Luu-The V. … Labrie F. (DNA Cell Biol. 1995) 3 4 22 64

Products for SULT2A1 Gene

Sources for SULT2A1 Gene

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