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Aliases for SULT2A1 Gene

Aliases for SULT2A1 Gene

  • Sulfotransferase Family, Cytosolic, 2A, Dehydroepiandrosterone (DHEA)-Preferring, Member 1 2 3
  • STD 3 4 6
  • DHEA-ST 3 4
  • ST2A1 3 4
  • ST2A3 3 4
  • HST 3 4
  • ST2 3 4
  • Alcohol/Hydroxysteroid Sulfotransferase 3
  • Dehydroepiandrosterone Sulfotransferase 4
  • Bile-Salt Sulfotranasferase 2A1 3
  • Hydroxysteroid Sulfotransferase 4
  • Bile Salt Sulfotransferase 3
  • Sulfotransferase 2A1 4
  • EC 2.8.2.14 4
  • DHEAS 3
  • HSTa 3

External Ids for SULT2A1 Gene

Previous Symbols for SULT2A1 Gene

  • STD

Summaries for SULT2A1 Gene

Entrez Gene Summary for SULT2A1 Gene

  • This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]

GeneCards Summary for SULT2A1 Gene

SULT2A1 (Sulfotransferase Family, Cytosolic, 2A, Dehydroepiandrosterone (DHEA)-Preferring, Member 1) is a Protein Coding gene. Diseases associated with SULT2A1 include polycystic ovary syndrome and cholangitis, primary sclerosing. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include sulfotransferase activity and bile-salt sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT2A1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands

Gene Wiki entry for SULT2A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT2A1 Gene

Genomics for SULT2A1 Gene

Genomic Location for SULT2A1 Gene

Start:
47,870,466 bp from pter
End:
47,886,397 bp from pter
Size:
15,932 bases
Orientation:
Minus strand

Genomic View for SULT2A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SULT2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT2A1 Gene

Regulatory Elements for SULT2A1 Gene

Proteins for SULT2A1 Gene

  • Protein details for SULT2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06520-ST2A1_HUMAN
    Recommended name:
    Bile salt sulfotransferase
    Protein Accession:
    Q06520
    Secondary Accessions:

    Protein attributes for SULT2A1 Gene

    Size:
    285 amino acids
    Molecular mass:
    33780 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Estrogens present in maternal circulation is predominantly derived from fetal dehydroepiandosterone sulfate which is hydrolyzed and metabolized to estrogens in placenta

    Three dimensional structures from OCA and Proteopedia for SULT2A1 Gene

neXtProt entry for SULT2A1 Gene

Proteomics data for SULT2A1 Gene at MOPED

Post-translational modifications for SULT2A1 Gene

Other Protein References for SULT2A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SULT2A1 Gene

Domains for SULT2A1 Gene

Gene Families for SULT2A1 Gene

HGNC:
  • SULT :Sulfotransferases, cytosolic

Protein Domains for SULT2A1 Gene

UniProtKB/Swiss-Prot:

ST2A1_HUMAN
Family:
  • Belongs to the sulfotransferase 1 family.:
    • Q06520
genes like me logo Genes that share domains with SULT2A1: view

Function for SULT2A1 Gene

Molecular function for SULT2A1 Gene

GENATLAS Biochemistry: hydroxysteroid dehydroepiandrosterone (DHEA) sulfotransferase,cytosolic,involved in the fine control of target cell sensitivity to hormone action,catalyzing the formation of DHEA-S,a major adrenal steroid,precursor for androgen and estrogen biosynthesis in peripheral tissues
UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + glycolithocholate = adenosine 3,5-bisphosphate + glycolithocholate 3-sulfate
UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + taurolithocholate = adenosine 3,5-bisphosphate + taurolithocholate sulfate
UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands

Enzyme Numbers (IUBMB) for SULT2A1 Gene

Gene Ontology (GO) - Molecular Function for SULT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
GO:0008146 sulfotransferase activity TAS --
GO:0047704 bile-salt sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with SULT2A1: view

Phenotypes for SULT2A1 Gene

GenomeRNAi human phenotypes for SULT2A1:
genes like me logo Genes that share phenotypes with SULT2A1: view

miRNA for SULT2A1 Gene

miRTarBase miRNAs that target SULT2A1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SULT2A1 Gene

Localization for SULT2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT2A1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT2A1 Gene COMPARTMENTS Subcellular localization image for SULT2A1 gene
Compartment Confidence
cytosol 4
extracellular 2
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for SULT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT2A1: view

Pathways for SULT2A1 Gene

genes like me logo Genes that share pathways with SULT2A1: view

Gene Ontology (GO) - Biological Process for SULT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0007586 digestion NAS 1588921
GO:0008202 steroid metabolic process TAS 1588921
GO:0030573 bile acid catabolic process IEA --
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with SULT2A1: view

Compounds for SULT2A1 Gene

(6) HMDB Compounds for SULT2A1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Androsterone
  • (3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one
53-41-8
Androsterone sulfate
  • 3alpha-Sulfate-5alpha-androstan-17-one
2479-86-9
Dehydroepiandrosterone
  • (+)-Dehydroisoandrosterone
53-43-0
DHEA sulfate
  • (3beta)-3-(sulfooxy)-Androst-5-en-17-one
651-48-9

(6) Drugbank Compounds for SULT2A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Abiraterone
154229-19-3 enzyme substrate
Acetaminophen
  • Acetaminofen
103-90-2 enzyme substrate
Adenosine-3'-5'-Diphosphate
target
Aetiocholanolone
53-42-9 target
Dehydroepiandrosterone
  • 3-beta-Hydroxy-5-androsten-17-one
53-43-0 target

(40) Novoseek inferred chemical compound relationships for SULT2A1 Gene

Compound -log(P) Hits PubMed IDs
hydroxysteroid 97.5 72
dhea 93.1 166
alpha-hydroxytamoxifen 91.2 6
1-hydroxyethylpyrene 89.9 2
2,6-dichloro-4-nitrophenol 86.4 2
genes like me logo Genes that share compounds with SULT2A1: view

Transcripts for SULT2A1 Gene

mRNA/cDNA for SULT2A1 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(67) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT2A1 Gene

Sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT2A1 Gene

No ASD Table

Relevant External Links for SULT2A1 Gene

GeneLoc Exon Structure for
SULT2A1
ECgene alternative splicing isoforms for
SULT2A1

Expression for SULT2A1 Gene

mRNA expression in normal human tissues for SULT2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT2A1 Gene

This gene is overexpressed in Liver (38.0) and Adrenal Gland (13.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SULT2A1 Gene

SOURCE GeneReport for Unigene cluster for SULT2A1 Gene Hs.515835

mRNA Expression by UniProt/SwissProt for SULT2A1 Gene

Q06520-ST2A1_HUMAN
Tissue specificity: Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney
genes like me logo Genes that share expressions with SULT2A1: view

Orthologs for SULT2A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT2A1 36
  • 98.21 (n)
  • 96.42 (a)
SULT2A1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 68 (a)
OneToMany
SULT2A1 36
  • 78.01 (n)
  • 69.47 (a)
SULT2A1 37
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 37 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 2810007J24Rik 37
  • 60 (a)
OneToMany
Sult2a1 36
  • 72.28 (n)
  • 63.86 (a)
Sult2a1 16
Sult2a1 37
  • 64 (a)
OneToMany
Sult2a3 37
  • 63 (a)
OneToMany
Sult2a4 37
  • 63 (a)
OneToMany
Sult2a5 37
  • 63 (a)
OneToMany
Sult2a6 37
  • 64 (a)
OneToMany
Sult2a7 37
  • 59 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SULT2A1 37
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 29 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Sult2a1 36
  • 72.34 (n)
  • 63.48 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 44 (a)
ManyToMany
-- 37
  • 47 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6711 36
sult2a1 36
  • 58.1 (n)
  • 51.41 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-236e20.3 37
  • 36 (a)
ManyToMany
sult2st1 37
  • 40 (a)
ManyToMany
sult2st1 37
  • 40 (a)
ManyToMany
sult2st2 37
  • 39 (a)
ManyToMany
sult2st3 37
  • 38 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y113G7A.11 38
  • 32 (a)
Species with no ortholog for SULT2A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SULT2A1 Gene

ENSEMBL:
Gene Tree for SULT2A1 (if available)
TreeFam:
Gene Tree for SULT2A1 (if available)

Paralogs for SULT2A1 Gene

Selected SIMAP similar genes for SULT2A1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SULT2A1 Gene

genes like me logo Genes that share paralogs with SULT2A1: view

Variants for SULT2A1 Gene

Sequence variations from dbSNP and Humsavar for SULT2A1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs177036 -- 47,887,254(+) TGTTT(G/T)TTTGT upstream-variant-2KB
rs177037 -- 47,887,503(+) CGCCA(A/C)GCCCA upstream-variant-2KB
rs212099 -- 47,885,745(+) TCCTA(A/T)CTGAA intron-variant
rs212100 -- 47,873,738(-) gctga(A/G)gcagg intron-variant
rs296359 -- 47,884,348(+) ttttt(A/T)aatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULT2A1 Gene

Variant ID Type Subtype PubMed ID
nsv428367 CNV Gain+Loss 18775914
nsv458715 CNV Gain 19166990
esv1006582 CNV Insertion 20482838
nsv523319 CNV Loss 19592680
esv2718669 CNV Deletion 23290073
esv2676204 CNV Deletion 23128226
nsv912213 CNV Loss 21882294
dgv3965n71 CNV Loss 21882294
nsv2513 CNV Loss 18451855
nsv828571 CNV Loss 20364138
nsv509748 CNV Insertion 20534489

Relevant External Links for SULT2A1 Gene

HapMap Linkage Disequilibrium report
SULT2A1
Human Gene Mutation Database (HGMD)
SULT2A1

Disorders for SULT2A1 Gene

(12) Novoseek inferred disease relationships for SULT2A1 Gene

Disease -log(P) Hits PubMed IDs
adenoma adrenocortical 63.7 1
cushing syndrome 29.7 3
carcinoma adrenocortical 29.5 1
cholangitis primary sclerosing 19.9 1
breast cancer 16.9 1

Relevant External Links for SULT2A1

Genetic Association Database (GAD)
SULT2A1
Human Genome Epidemiology (HuGE) Navigator
SULT2A1
genes like me logo Genes that share disorders with SULT2A1: view

No data available for UniProtKB/Swiss-Prot for SULT2A1 Gene

Publications for SULT2A1 Gene

  1. Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. (PMID: 14573603) Chang H.J. … Lin S.X. (J. Biol. Chem. 2004) 3 4 23 26
  2. Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver. (PMID: 1520333) Kong A.-N.T. … Bjornsson T.D. (Biochem. Biophys. Res. Commun. 1992) 3 4 23
  3. Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme. (PMID: 7589785) Forbes K.J. … Hume R. (Mol. Cell. Endocrinol. 1995) 3 4 23
  4. Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene. (PMID: 7598806) Luu-The V. … Labrie F. (DNA Cell Biol. 1995) 3 4 23
  5. Cloning and expression of human liver dehydroepiandrosterone sulphotransferase. (PMID: 7678732) Comer K.A. … Falany C.N. (Biochem. J. 1993) 3 4 23

Products for SULT2A1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SULT2A1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SULT2A1
    • Block miRNA regulation of SULT2A1 using miScript Target Protectors

    Sources for SULT2A1 Gene

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