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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SULT2A1 Gene

protein-coding   GIFtS: 69
GCID: GC19M048373

Sulfotransferase Family, Cytosolic, 2A, Dehydroepiandrosterone...


(Previous symbol: STD)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sulfotransferase Family, Cytosolic, 2A, Dehydroepiandrosterone
(DHEA)-Preferring, Member 11 2
     Alcohol/Hydroxysteroid Sulfotransferase2
STD1 2 3 5     Bile Salt Sulfotransferase2
DHEA-ST2 3     Bile-Salt Sulfotranasferase 2A12
HST2 3     hSTa2
ST22 3     EC 2.8.2.143
ST2A12 3     Dehydroepiandrosterone Sulfotransferase3
ST2A32 3     Hydroxysteroid Sulfotransferase3
DHEAS2     Sulfotransferase 2A13

External Ids:    HGNC: 114581   Entrez Gene: 68222   Ensembl: ENSG000001053987   OMIM: 1252635   UniProtKB: Q065203   

Export aliases for SULT2A1 gene to outside databases

Previous GC identifers: GC19M049020 GC19M048765 GC19M053049 GC19M053065 GC19M044800


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SULT2A1 Gene:
This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and
endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that
can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal
glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome.
(provided by RefSeq, Mar 2010)

GeneCards Summary for SULT2A1 Gene: 
SULT2A1 (sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1) is a protein-coding gene. Diseases associated with SULT2A1 include polycystic ovary syndrome, and x-linked ichthyosis, and among its related super-pathways are Tamoxifen Pathway, Pharmacokinetics and Phase II conjugation. GO annotations related to this gene include sulfotransferase activity and bile-salt sulfotransferase activity. An important paralog of this gene is SULT1C3.

UniProtKB/Swiss-Prot: ST2A1_HUMAN, Q06520
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfonation of steroids and bile acids in the liver and adrenal glands

Gene Wiki entry for SULT2A1 (Bile salt sulfotransferase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SULT2A1 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SULT2A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SULT2A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULT2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

SULT2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT2A1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M048373:  view genomic region     (about GC identifiers)

Start:
48,373,723 bp from pter      End:
48,389,654 bp from pter
Size:
15,932 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ST2A1_HUMAN, Q06520 (See protein sequence)
Recommended Name: Bile salt sulfotransferase  
Size: 285 amino acids; 33780 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
Miscellaneous: Estrogens present in maternal circulation is predominantly derived from fetal dehydroepiandosterone
sulfate which is hydrolyzed and metabolized to estrogens in placenta
6/7 PDB 3D structures from and Proteopedia for SULT2A1 (see all 7):
1EFH (3D)        1J99 (3D)        1OV4 (3D)        2QP3 (3D)        2QP4 (3D)        3F3Y (3D)    

Explore the universe of human proteins at neXtProt for SULT2A1: NX_Q06520

Explore proteomics data for SULT2A1 at MOPED 

Post-translational modifications:

  • UniProtKB: The N-terminus is blocked
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q06520

  • SULT2A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SULT2A1 Protein Expression
    REFSEQ proteins: NP_003158.2  
    ENSEMBL proteins: 
     ENSP00000222002  
    Reactome Protein details: Q06520
    Human Recombinant Protein Products for SULT2A1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SULT2A1 (Cytosolic Sulfotransferase 2A1/SULT2A1)
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    OriGene Purified Protein for SULT2A1
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    Novus Biologicals SULT2A1 Proteins
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    Sino Biological Recombinant Protein for SULT2A1
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SULT2A1
    Cloud-Clone Corp. Proteins for SULT2A1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    SULT2A1 for ontologies           About GeneDecksing



    SULT2A1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SULT: Sulfotransferases, cytosolic

    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry Q06520

    ProtoNet protein and cluster: Q06520

    1 Blocks protein domain: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST2A1_HUMAN, Q06520
    Similarity: Belongs to the sulfotransferase 1 family


    SULT2A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST2A1_HUMAN, Q06520
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    sulfonation of steroids and bile acids in the liver and adrenal glands
    Catalytic activity: 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate +
    glycolithocholate 3-sulfate
    Catalytic activity: 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate +
    taurolithocholate sulfate

         Genatlas biochemistry entry for SULT2A1:
    hydroxysteroid dehydroepiandrosterone (DHEA) sulfotransferase,cytosolic,involved in the fine control of target
    cell sensitivity to hormone action,catalyzing the formation of DHEA-S,a major adrenal steroid,precursor for
    androgen and estrogen biosynthesis in peripheral tissues

         Enzyme Number (IUBMB): EC 2.8.2.141

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008146sulfotransferase activity TAS--
    GO:0047704bile-salt sulfotransferase activity IEA--
         
    SULT2A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SULT2A1:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SULT2A1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SULT2A1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SULT2A1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SULT2A1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SULT2A1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SULT2A1
    SwitchGear 3'UTR luciferase reporter plasmidSULT2A1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for SULT2A1
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SULT2A1 (NM_003167)
    Sino Biological Human cDNA Clone for SULT2A1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SULT2A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULT2A1
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                         Customized lentivirus expression plasmids for stable overexpression of SULT2A1 

    Cell Line
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    Search LifeMap BioReagents cell lines for SULT2A1
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT2A1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SULT2A1 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Tamoxifen metabolism
    Tamoxifen metabolism0.68
    Estradiol metabolism0.52
    Tamoxifen Pathway, Pharmacokinetics0.68
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    3Cytosolic sulfonation of small molecules
    Cytosolic sulfonation of small molecules0.52
    Sulfation Biotransformation Reaction0.52
    4Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74
    5Drug metabolism - cytochrome P450
    Chemical carcinogenesis0.77
    Metabolism of xenobiotics by cytochrome P4500.77

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for SULT2A1
        Androstenedione and testosterone biosynthesis and metabolism p.1
    Estradiol metabolism


    2 GeneGo (Thomson Reuters) Pathways for SULT2A1
        Estradiol metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.1

    5 BioSystems Pathways for SULT2A1
        Sulfation Biotransformation Reaction
    Tamoxifen metabolism
    Drug Induction of Bile Acid Pathway
    E2F transcription factor network
    metapathway biotransformation


    5/8        Reactome Pathways for SULT2A1 (see all 8)
        Metabolism
    Cytosolic sulfonation of small molecules
    Fatty acid, triacylglycerol, and ketone body metabolism
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    PPARA Activates Gene Expression

    3 PharmGKB Pathways for SULT2A1
        Acetaminophen Pathway, Pharmacokinetics
    Estrogen Metabolism Pathway
    Tamoxifen Pathway, Pharmacokinetics

    3         Kegg Pathways  (Kegg details for SULT2A1):
        Metabolism of xenobiotics by cytochrome P450
    Bile secretion
    Chemical carcinogenesis


    SULT2A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SULT2A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for SULT2A1 (Q065201 ENSP000002220024) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT3P407631, ENSP000002646574EBI-3921363,EBI-518675 STRING: ENSP00000264657
    CARM1ENSP000003256904STRING: ENSP00000325690
    PPARAENSP000002627354STRING: ENSP00000262735
    RXRAENSP000004196924STRING: ENSP00000419692
    BPNT1ENSP000003188524STRING: ENSP00000318852
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007586digestion NAS1588921
    GO:0008202steroid metabolic process TAS1588921
    GO:0030573bile acid catabolic process IEA--
    GO:0044255cellular lipid metabolic process TAS--

    SULT2A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SULT2A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SULT2A1 (ST2A1)

    6 HMDB Compounds for SULT2A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Androsterone(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one (see all 28)53-41-814573603
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Androsterone sulfate3alpha-Sulfate-5alpha-androstan-17-one (see all 8)2479-86-9--
    DHEA sulfate(3beta)-3-(sulfooxy)-Androst-5-en-17-one (see all 16)651-48-9--
    Dehydroepiandrosterone(+)-Dehydroisoandrosterone (see all 42)53-43-0--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--

    6 DrugBank Compounds for SULT2A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aetiocholanolone-- 53-42-9target--17139284 17016423 10592235
    Dehydroepiandrosterone3-beta-Hydroxy-5-androsten-17-one (see all 6)53-43-0target--17139284 17016423 10592235
    Adenosine-3'-5'-Diphosphate-- --target--17139284 17016423
    Mercury Diiodide-- --target--17139284 17016423
    Abiraterone -- 154229-19-3enzymesubstrate22714819
    AcetaminophenAcetaminofen (see all 5)103-90-2enzymesubstrate18232020

    10/40 Novoseek inferred chemical compound relationships for SULT2A1 gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxysteroid 97.5 110 9806149 (3), 15371299 (3), 7589232 (3), 15644508 (3) (see all 61)
    dhea 93.1 279 9010352 (12), 8971138 (11), 1355717 (6), 8222492 (6) (see all 83)
    alpha-hydroxytamoxifen 91.2 8 9806149 (3), 9855017 (1), 11358807 (1), 12419845 (1)
    1-hydroxyethylpyrene 89.9 2 9636676 (1), 7589232 (1)
    2,6-dichloro-4-nitrophenol 86.4 4 7859374 (1), 8097696 (1)
    3-phosphoadenosine 5'-phosphosulfate 83.9 11 15483193 (1), 16099924 (1), 14573603 (1), 15198932 (1) (see all 5)
    dehydroepiandrosterone sulfate 82.9 24 17426092 (3), 15084485 (2), 8751327 (1), 7859374 (1) (see all 16)
    3'-phosphoadenosine 5'-phosphate 78.7 2 7697798 (1)
    phenol 74.8 50 8563037 (2), 1355717 (2), 7589232 (2), 10503886 (1) (see all 21)
    3beta-hydroxysteroid 71.7 9 11155097 (1), 11744071 (1), 12589943 (1), 15878968 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about SULT2A1 / ST2A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SULT2A1 gene: 
    NM_003167.3  

    Unigene Cluster for SULT2A1:

    Sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
    Hs.515835  [show with all ESTs]
    Unigene Representative Sequence: NM_003167
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000222002(uc002phr.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK289380.1 AK313415.1 BC020755.1 L02337.1 L20000.1 S43859.1 S43861.1 U08024.1 
    U08025.1 X70222.1 X84816.1 

    5 DOTS entries:

    DT.314614  DT.100773398  DT.92424924  DT.100773401  DT.95257375 

    24/67 AceView cDNA sequences (see all 67):

    BX509439 CB157413 CR608228 AI382378 AI028152 C21053 BQ013785 L20000 
    AA328456 BC020755 BV192014 AV705351 T28260 BG563083 BG568285 NM_003167 
    BX509490 AA443380 U08025 BG616732 CB163674 AI151302 BX406268 U08024 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SULT2A1 expression in normal human tissues (normalized intensities)      SULT2A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATCCCAGA
    SULT2A1 Expression
    About this image


    SULT2A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine ; glandular cells   
             small intestine   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Adrenal Gland (Endocrine System)    fully expand to see all 2 entries
             adrenal gland ; glandular cells   
             adrenal cortex   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   

    See SULT2A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SULT2A1

    SOURCE GeneReport for Unigene cluster: Hs.515835

    UniProtKB/Swiss-Prot: ST2A1_HUMAN, Q06520
    Tissue specificity: Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in
    the adrenal than the liver and the kidney

        SABiosciences Expression via Pathway-Focused PCR Array including SULT2A1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SULT2A1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sult2a11 , 5 sulfotransferase family 2A, dehydroepiandrosterone more1, 5 72.28(n)1
    63.86(a)1
      7 (8.02 cM)5
    208591  NM_001111296.21  NP_001104766.11 
     137962465 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    44(a)
    possible ortholog
    GL343279.1(1042027-1050181)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.67112 Transcribed sequence with weak similarity to protein more 74.48(n)    BQ527455.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sult2st26
    sult2st16
    (see all 4)
    sulfotransferase family 2, cytosolic sulfotransfer...
    sulfotransferase family 2, cytosolic sulfotransfer...
    (see all 4)
    39(a)
    39(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    12(805224-853475)
    12(827230-842907)


    ENSEMBL Gene Tree for SULT2A1 (if available)
    TreeFam Gene Tree for SULT2A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SULT2A1 gene
    SULT1C32  SULT4A12  SULT1B12  SULT1A22  SULT1C42  SULT1C22  SULT1E12  SULT2B12  
    SULT1A42  SULT6B12  SULT1A12  SULT1A32  
    13 SIMAP similar genes for SULT2A1 using alignment to 2 protein entries:     ST2A1_HUMAN (see all proteins):
    SULT2B1    SULT1A1    SULT1A2    SULT1A3    SULT1A4    SULT1C4
    ST1A5    SULT1C2    SULT1B1    SULT1C3    SULT1E1    SULT6B1
    SULT4A1

    SULT2A1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SULT2A1
    PGOHUM00000234440 PGOHUM00000234802


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/488 SNPs in SULT2A1 are shown (see all 488)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs612717631,2
    C--44803666(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- int11NA 2
    rs1386419101,2
    C--44807240(+) CTTTT-/ATGTG 
     AGATATC
    ACTAA
    1 -- int10--------
    rs637497061,2
    F--44807241(-) TTAGTGATATC  
     TCACA
    /-
    TAAAA
    1 -- int15Minor allele frequency- -:0.12NS 156
    rs582964291,2
    C,F--44809969(+) AAAAA-/ACCTAG 1 -- int17Minor allele frequency- A:0.11NS NA CSA 184
    rs1431228941,2
    C--44814176(+) TTTTA-/TTAT  
            
    TTATT
    1 -- int10--------
    rs1124684111,2
    C,F--48374306(+) ATGTTG/AGCCAG 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs1122850021,2
    C,F--48374320(+) GGTCTC/TGATCT 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs346423761,2
    C--48380026(+) CTAAA-/A/AAA 
            
    AAAAA
    2 -- int1 cds11NA 2
    rs106769041,2
    C--48380342(+) aaaaaAA/-aaaaa 1 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs625310051,2
    C,F--48380915(-) GTAGGA/TGAATC 1 -- int15Minor allele frequency- T:0.01NS 186

    HapMap Linkage Disequilibrium report for SULT2A1 (48373723 - 48389654 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for SULT2A1 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676204CNV Deletion23128226
    esv2718669CNV Deletion23290073
    esv1006582CNV Insertion20482838
    nsv509748CNV Insertion20534489
    nsv2513CNV Loss18451855
    nsv828571CNV Loss20364138
    nsv912213CNV Loss21882294
    dgv3965n71CNV Loss21882294
    nsv523319CNV Loss19592680
    nsv458715CNV Gain19166990


    Human Gene Mutation Database (HGMD): SULT2A1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 125263    OMIM disorders: --

    20/32 diseases for SULT2A1 (see all 32):    About MalaCards
    polycystic ovary syndrome    x-linked ichthyosis    cushing's syndrome    polymyalgia rheumatica
    anovulation    adrenal adenoma    endometrial adenocarcinoma    amenorrhea
    hyperinsulinism    precocious puberty    hyperandrogenism    ichthyosis
    alcoholism    cholangitis    hepatoblastoma    hypogonadism
    liver disease    adenoma    fatty liver disease    hepatocellular carcinoma

    9 diseases from the University of Copenhagen DISEASES database for SULT2A1:
    Polycystic ovary syndrome     Hyperandrogenism     Amenorrhea     Anovulation
    Hyperinsulinism     Infertility     Cushing's syndrome     X-linked ichthyosis
    Adrenal adenoma

    SULT2A1 for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for SULT2A1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenoma adrenocortical 63.7 1 8751327 (1)
    cushing syndrome 29.7 4 8930526 (2), 11456263 (1)
    carcinoma adrenocortical 29.5 1 8751327 (1)
    cholangitis primary sclerosing 19.9 1 10726960 (1)
    breast cancer 16.9 2 19308726 (1)
    hepatocellular carcinoma 14.4 4 15667595 (1), 15713538 (1)
    atrophy 0 2 14567506 (1), 17318025 (1)
    liver diseases 0 1 10726960 (1)
    adenoma 0 10 8751327 (3), 17408424 (1)
    tumors 0 8 11456263 (1), 15713538 (1), 1419884 (1), 17318025 (1)

    Genetic Association Database (GAD): SULT2A1
    Human Genome Epidemiology (HuGE) Navigator: SULT2A1 (6 documents)

    Export disorders for SULT2A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SULT2A1 gene, integrated from 9 sources (see all 188):
    (articles sorted by number of sources associating them with SULT2A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. (PubMed id 14573603)1, 2, 6, 9 Chang H.J.... Lin S.X. (2004)
    2. Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA. (PubMed id 1588921)1, 2, 3 Otterness D.M.... Weinshilboum R.M. (1992)
    3. Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization. (PubMed id 7710689)1, 2, 9 Otterness D.M....Weinshilboum R.M. (1995)
    4. Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome. (PubMed id 17426092)1, 4, 9 Goodarzi M.O....Azziz R. (2007)
    5. Cloning and expression of human liver dehydroepiandrosterone sulphotransferase. (PubMed id 7678732)1, 2, 9 Comer K.A.... Falany C.N. (1993)
    6. Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3. (PubMed id 7736787)1, 3, 9 Otterness D.M....Weinshilboum R.M. (1995)
    7. Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme. (PubMed id 7589785)1, 2, 9 Forbes K.J.... Hume R. (1995)
    8. Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate. (PubMed id 11988089)1, 2, 9 Rehse P.H.... Lin S.X. (2002)
    9. Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase. (PubMed id 10854859)1, 2, 9 Pedersen L.C.... Negishi M. (2000)
    10. Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene. (PubMed id 7598806)1, 2, 9 Luu-The V.... Labrie F. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6822 HGNC: 11458 AceView: SULT2A1 Ensembl:ENSG00000105398 euGenes: HUgn6822
    ECgene: SULT2A1 Kegg: 6822 H-InvDB: SULT2A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SULT2A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SULT2A1 gene:
    Search GeneIP for patents involving SULT2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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