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SULT2A1 Gene

protein-coding   GIFtS: 69
GCID: GC19M048373

Sulfotransferase Family, Cytosolic, 2A, Dehydroepiandrosterone...


(Previous symbol: STD)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sulfotransferase Family, Cytosolic, 2A, Dehydroepiandrosterone
(DHEA)-Preferring, Member 11 2
     Alcohol/Hydroxysteroid Sulfotransferase2
STD1 2 3 5     Bile Salt Sulfotransferase2
DHEA-ST2 3     Bile-Salt Sulfotranasferase 2A12
HST2 3     hSTa2
ST22 3     EC 2.8.2.143
ST2A12 3     Dehydroepiandrosterone Sulfotransferase3
ST2A32 3     Hydroxysteroid Sulfotransferase3
DHEAS2     Sulfotransferase 2A13

External Ids:    HGNC: 114581   Entrez Gene: 68222   Ensembl: ENSG000001053987   OMIM: 1252635   UniProtKB: Q065203   

Export aliases for SULT2A1 gene to outside databases

Previous GC identifers: GC19M049020 GC19M048765 GC19M053049 GC19M053065 GC19M044800


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SULT2A1 Gene:
This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and
endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that
can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal
glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome.
(provided by RefSeq, Mar 2010)

GeneCards Summary for SULT2A1 Gene:
SULT2A1 (sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1) is a protein-coding gene. Diseases associated with SULT2A1 include polycystic ovary syndrome, and x-linked ichthyosis. GO annotations related to this gene include sulfotransferase activity and bile-salt sulfotransferase activity. An important paralog of this gene is SULT1C3.

UniProtKB/Swiss-Prot: ST2A1_HUMAN, Q06520
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfonation of steroids and bile acids in the liver and adrenal glands

Gene Wiki entry for SULT2A1 (Bile salt sulfotransferase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SULT2A1 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SULT2A1 promoter sequence
   Search Chromatin IP Primers for SULT2A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SULT2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

SULT2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT2A1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M048373:  view genomic region     (about GC identifiers)

Start:
48,373,723 bp from pter      End:
48,389,654 bp from pter
Size:
15,932 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ST2A1_HUMAN, Q06520 (See protein sequence)
Recommended Name: Bile salt sulfotransferase  
Size: 285 amino acids; 33780 Da
Subunit: Homodimer
Miscellaneous: Estrogens present in maternal circulation is predominantly derived from fetal dehydroepiandosterone
sulfate which is hydrolyzed and metabolized to estrogens in placenta
Selected PDB 3D structures from and Proteopedia for SULT2A1 (see all 7):
1EFH (3D)        1J99 (3D)        1OV4 (3D)        2QP3 (3D)        2QP4 (3D)        3F3Y (3D)    

Explore the universe of human proteins at neXtProt for SULT2A1: NX_Q06520

Explore proteomics data for SULT2A1 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SULT2A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003158.2  
    ENSEMBL proteins: 
     ENSP00000222002  
    Reactome Protein details: Q06520

    SULT2A1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULT: Sulfotransferases, cytosolic

    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry Q06520

    ProtoNet protein and cluster: Q06520

    1 Blocks protein domain: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST2A1_HUMAN, Q06520
    Similarity: Belongs to the sulfotransferase 1 family


    SULT2A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST2A1_HUMAN, Q06520
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    sulfonation of steroids and bile acids in the liver and adrenal glands
    Catalytic activity: 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate +
    glycolithocholate 3-sulfate
    Catalytic activity: 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate +
    taurolithocholate sulfate

         Genatlas biochemistry entry for SULT2A1:
    hydroxysteroid dehydroepiandrosterone (DHEA) sulfotransferase,cytosolic,involved in the fine control of target
    cell sensitivity to hormone action,catalyzing the formation of DHEA-S,a major adrenal steroid,precursor for
    androgen and estrogen biosynthesis in peripheral tissues

         Enzyme Number (IUBMB): EC 2.8.2.141

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008146sulfotransferase activity TAS--
    GO:0047704bile-salt sulfotransferase activity IEA--
         
    SULT2A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SULT2A1:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SULT2A1
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    miRNA
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    miRTarBase miRNAs that target SULT2A1:
    hsa-mir-335-5p (MIRT017405), hsa-mir-24-3p (MIRT030437)

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    Search for qRT-PCR Assays for microRNAs that regulate SULT2A1
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ST2A1_HUMAN, Q06520: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular2
    nucleus2
    peroxisome2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    SULT2A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SULT2A1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Tamoxifen metabolism0.00
    Phase II conjugation0.56
    Estradiol metabolism0.00
    metapathway biotransformation0.42
    Tamoxifen Pathway, Pharmacokinetics0.00
    Cytosolic sulfonation of small molecules0.00
    2Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    3Chemical carcinogenesis
    Metabolism of xenobiotics by cytochrome P4500.71
    Chemical carcinogenesis0.71
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    5Estrone metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.10.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for SULT2A1
        Estradiol metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.1

    Selected BioSystems Pathways for SULT2A1 (see all 6)
        Sulfation Biotransformation Reaction
    Tamoxifen metabolism
    Drug Induction of Bile Acid Pathway
    Corticotropin-releasing hormone
    E2F transcription factor network


    2 Reactome Pathways for SULT2A1
        PPARA activates gene expression
    Cytosolic sulfonation of small molecules

    3 PharmGKB Pathways for SULT2A1
        Acetaminophen Pathway, Pharmacokinetics
    Estrogen Metabolism Pathway
    Tamoxifen Pathway, Pharmacokinetics

    3 Kegg Pathways  (Kegg details for SULT2A1):
        Metabolism of xenobiotics by cytochrome P450
    Bile secretion
    Chemical carcinogenesis


    SULT2A1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SULT2A1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SULT2A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for SULT2A1 (Q065201 ENSP000002220024) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT3P407631, ENSP000002646574EBI-3921363,EBI-518675 STRING: ENSP00000264657
    CARM1ENSP000003256904STRING: ENSP00000325690
    PPARAENSP000002627354STRING: ENSP00000262735
    RXRAENSP000004196924STRING: ENSP00000419692
    BPNT1ENSP000003188524STRING: ENSP00000318852
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007586digestion NAS1588921
    GO:0008202steroid metabolic process TAS1588921
    GO:0030573bile acid catabolic process IEA--
    GO:0044255cellular lipid metabolic process TAS--

    SULT2A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SULT2A1 (ST2A1)

    6 HMDB Compounds for SULT2A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Androsterone(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one (see all 28)53-41-814573603
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Androsterone sulfate3alpha-Sulfate-5alpha-androstan-17-one (see all 8)2479-86-9--
    DHEA sulfate(3beta)-3-(sulfooxy)-Androst-5-en-17-one (see all 16)651-48-9--
    Dehydroepiandrosterone(+)-Dehydroisoandrosterone (see all 42)53-43-0--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--

    6 DrugBank Compounds for SULT2A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aetiocholanolone-- 53-42-9target--17139284 17016423 10592235
    Dehydroepiandrosterone3-beta-Hydroxy-5-androsten-17-one (see all 6)53-43-0target--17139284 17016423 10592235
    Adenosine-3'-5'-Diphosphate-- --target--17139284 17016423
    Mercury Diiodide-- --target--17139284 17016423
    Abiraterone -- 154229-19-3enzymesubstrate22714819
    AcetaminophenAcetaminofen (see all 5)103-90-2enzymesubstrate18232020

    Selected Novoseek inferred chemical compound relationships for SULT2A1 gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxysteroid 97.5 110 9806149 (3), 15371299 (3), 7589232 (3), 15644508 (3) (see all 61)
    dhea 93.1 279 9010352 (12), 8971138 (11), 1355717 (6), 8222492 (6) (see all 83)
    alpha-hydroxytamoxifen 91.2 8 9806149 (3), 9855017 (1), 11358807 (1), 12419845 (1)
    1-hydroxyethylpyrene 89.9 2 9636676 (1), 7589232 (1)
    2,6-dichloro-4-nitrophenol 86.4 4 7859374 (1), 8097696 (1)
    3-phosphoadenosine 5'-phosphosulfate 83.9 11 15483193 (1), 16099924 (1), 14573603 (1), 15198932 (1) (see all 5)
    dehydroepiandrosterone sulfate 82.9 24 17426092 (3), 15084485 (2), 8751327 (1), 7859374 (1) (see all 16)
    3'-phosphoadenosine 5'-phosphate 78.7 2 7697798 (1)
    phenol 74.8 50 8563037 (2), 1355717 (2), 7589232 (2), 10503886 (1) (see all 21)
    3beta-hydroxysteroid 71.7 9 11155097 (1), 11744071 (1), 12589943 (1), 15878968 (1) (see all 5)



    SULT2A1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SULT2A1 gene: 
    NM_003167.3  

    Unigene Cluster for SULT2A1:

    Sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
    Hs.515835  [show with all ESTs]
    Unigene Representative Sequence: NM_003167
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000222002(uc002phr.2)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK289380.1 AK313415.1 BC020755.1 L02337.1 L20000.1 S43859.1 S43861.1 U08024.1 
    U08025.1 X70222.1 X84816.1 

    5 DOTS entries:

    DT.314614  DT.100773398  DT.92424924  DT.100773401  DT.95257375 

    Selected AceView cDNA sequences (see all 67):

    BX509439 BQ013785 CR608228 AI028152 CB157413 C21053 AI382378 CB163674 
    AA328456 BG616732 AV705351 BV192014 U08025 X84816 BV192013 L02337 
    L20000 BC020755 NM_003167 S43859 S43861 T28260 AI151302 AA443380 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SULT2A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATCCCAGA
    SULT2A1 Expression
    About this image


    SULT2A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Hepatocyte-like cells
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Brain (Nervous System)
             Cerebral Cortex
    SULT2A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SULT2A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515835

    UniProtKB/Swiss-Prot: ST2A1_HUMAN, Q06520
    Tissue specificity: Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in
    the adrenal than the liver and the kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including SULT2A1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SULT2A1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sult2a11 , 5 sulfotransferase family 2A, dehydroepiandrosterone more1, 5 72.28(n)1
    63.86(a)1
      7 (8.02 cM)5
    208591  NM_001111296.21  NP_001104766.11 
     137962465 
    chicken
    (Gallus gallus)
    Aves --
    Gallus gallus sulfotransferase (LOC395933), mRNA.
    31(a)
    many ↔ many
    3(41121124-41158394)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    47(a)
    44(a)
    many ↔ many
    many ↔ many
    GL343281.1(1089858-1105095)
    GL343279.1(1042027-1050181)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.67112 Transcribed sequence with weak similarity to protein more 74.48(n)    BQ527455.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sult2st16
    sult2st16
    (see all 5)
    sulfotransferase family 2, cytosolic sulfotransfer...
    sulfotransferase family 2, cytosolic sulfotransfer...
    (see all 5)
    40(a)
    40(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    12(827230-842907) ENSDARG00000033170
    12(790716-802675) ENSDARG00000086446


    ENSEMBL Gene Tree for SULT2A1 (if available)
    TreeFam Gene Tree for SULT2A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SULT2A1 gene
    SULT1C32  SULT4A12  SULT1B12  SULT1A22  SULT1C42  SULT1C22  SULT1E12  SULT2B12  
    SULT1A42  SULT6B12  SULT1A12  SULT1A32  
    13 SIMAP similar genes for SULT2A1 using alignment to 2 protein entries:     ST2A1_HUMAN (see all proteins):
    SULT2B1    SULT1A1    ST1A5    SULT1A2    SULT1A3    SULT1A4
    SULT1C4    SULT1C2    SULT1B1    SULT1C3    SULT1E1    SULT6B1
    SULT4A1

    SULT2A1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SULT2A1
    PGOHUM00000234440 PGOHUM00000234802


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SULT2A1 (see all 488)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs612717631,2
    C--44803666(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- int11NA 2
    rs1386419101,2
    C--44807240(+) CTTTT-/ATGTG 
     AGATATC
    ACTAA
    1 -- int10--------
    rs637497061,2
    F--44807241(-) TTAGTGATATC  
     TCACA
    /-
    TAAAA
    1 -- int15Minor allele frequency- -:0.12NS 156
    rs582964291,2
    C,F--44809969(+) AAAAA-/ACCTAG 1 -- int17Minor allele frequency- A:0.11NS NA CSA 184
    rs1431228941,2
    C--44814176(+) TTTTA-/TTAT  
            
    TTATT
    1 -- int10--------
    rs1124684111,2
    C,F--48374306(+) ATGTTG/AGCCAG 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs1122850021,2
    C,F--48374320(+) GGTCTC/TGATCT 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs346423761,2
    C--48380026(+) CTAAA-/A/AAA 
            
    AAAAA
    2 -- int1 cds11NA 2
    rs106769041,2
    C--48380342(+) aaaaaAA/-aaaaa 1 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs625310051,2
    C,F--48380915(-) GTAGGA/TGAATC 1 -- int15Minor allele frequency- T:0.01NS 186

    HapMap Linkage Disequilibrium report for SULT2A1 (48373723 - 48389654 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SULT2A1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676204CNV Deletion23128226
    esv2718669CNV Deletion23290073
    esv1006582CNV Insertion20482838
    nsv509748CNV Insertion20534489
    nsv2513CNV Loss18451855
    nsv828571CNV Loss20364138
    nsv912213CNV Loss21882294
    dgv3965n71CNV Loss21882294
    nsv523319CNV Loss19592680
    nsv458715CNV Gain19166990

    Human Gene Mutation Database (HGMD): SULT2A1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SULT2A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SULT2A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 125263    OMIM disorders: --

    Selected diseases for SULT2A1 (see all 31):    
    About MalaCards
    polycystic ovary syndrome    x-linked ichthyosis    polymyalgia rheumatica    cushing's syndrome
    anovulation    adrenal adenoma    asperger syndrome    endometrial adenocarcinoma
    amenorrhea    hyperinsulinism    precocious puberty    hyperandrogenism
    liver disease    fatty liver disease    hypogonadism    cholangitis
    hepatoblastoma    adenoma    hepatocellular carcinoma    dementia

    9 diseases from the University of Copenhagen DISEASES database for SULT2A1:
    Polycystic ovary syndrome     Hyperandrogenism     Amenorrhea     Anovulation
    Hyperinsulinism     Infertility     Cushing's syndrome     X-linked ichthyosis
    Adrenal adenoma

    SULT2A1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SULT2A1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenoma adrenocortical 63.7 1 8751327 (1)
    cushing syndrome 29.7 4 8930526 (2), 11456263 (1)
    carcinoma adrenocortical 29.5 1 8751327 (1)
    cholangitis primary sclerosing 19.9 1 10726960 (1)
    breast cancer 16.9 2 19308726 (1)
    hepatocellular carcinoma 14.4 4 15667595 (1), 15713538 (1)
    atrophy 0 2 14567506 (1), 17318025 (1)
    liver diseases 0 1 10726960 (1)
    adenoma 0 10 8751327 (3), 17408424 (1)
    tumors 0 8 11456263 (1), 15713538 (1), 1419884 (1), 17318025 (1)

    Genetic Association Database (GAD): SULT2A1
    Human Genome Epidemiology (HuGE) Navigator: SULT2A1 (6 documents)

    Export disorders for SULT2A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SULT2A1 gene, integrated from 10 sources (see all 191):
    (articles sorted by number of sources associating them with SULT2A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. (PubMed id 14573603)1, 2, 6, 9 Chang H.J.... Lin S.X. (J. Biol. Chem. 2004)
    2. Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA. (PubMed id 1588921)1, 2, 3 Otterness D.M.... Weinshilboum R.M. (Mol. Pharmacol. 1992)
    3. Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization. (PubMed id 7710689)1, 2, 9 Otterness D.M....Weinshilboum R.M. (DNA Cell Biol. 1995)
    4. Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome. (PubMed id 17426092)1, 4, 9 Goodarzi M.O....Azziz R. (J. Clin. Endocrinol. Metab. 2007)
    5. Cloning and expression of human liver dehydroepiandrosterone sulphotransferase. (PubMed id 7678732)1, 2, 9 Comer K.A.... Falany C.N. (Biochem. J. 1993)
    6. Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3. (PubMed id 7736787)1, 3, 9 Otterness D.M....Weinshilboum R.M. (Cytogenet. Cell Genet. 1995)
    7. Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme. (PubMed id 7589785)1, 2, 9 Forbes K.J.... Hume R. (Mol. Cell. Endocrinol. 1995)
    8. Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate. (PubMed id 11988089)1, 2, 9 Rehse P.H.... Lin S.X. (Biochem. J. 2002)
    9. Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase. (PubMed id 10854859)1, 2, 9 Pedersen L.C.... Negishi M. (FEBS Lett. 2000)
    10. Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene. (PubMed id 7598806)1, 2, 9 Luu-The V.... Labrie F. (DNA Cell Biol. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6822 HGNC: 11458 AceView: SULT2A1 Ensembl:ENSG00000105398 euGenes: HUgn6822
    ECgene: SULT2A1 Kegg: 6822 H-InvDB: SULT2A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SULT2A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SULT2A1 gene:
    Search GeneIP for patents involving SULT2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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