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SULT1E1 Gene

protein-coding   GIFtS: 68
GCID: GC04M070676

Sulfotransferase Family 1E, Estrogen-Preferring, Member...

(Previous names: sulfotransferase, estrogen-preferring)
(Previous symbol: STE)
  See SULT1E1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sulfotransferase Family 1E, Estrogen-Preferring, Member 11 2     EC 2.8.2.43 8
STE1 2 3 5     EST2 5
Sulfotransferase, Estrogen-Preferring1 2 3     Estrogen Sulfotransferase2
Sulfotransferase 1E12 3     Estrone Sulfotransferase2
EST-12 3     EC 2.8.28
ST1E12 3     

External Ids:    HGNC: 113771   Entrez Gene: 67832   Ensembl: ENSG000001091937   OMIM: 6000435   UniProtKB: P498883   

Export aliases for SULT1E1 gene to outside databases

Previous GC identifers: GC04M071022 GC04M070887 GC04M070741 GC04M066504


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SULT1E1 Gene:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and
xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate
specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes
a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SULT1E1 Gene:
SULT1E1 (sulfotransferase family 1E, estrogen-preferring, member 1) is a protein-coding gene. Diseases associated with SULT1E1 include endometrial adenocarcinoma, and endometrial stromal sarcoma. GO annotations related to this gene include steroid sulfotransferase activity and steroid binding. An important paralog of this gene is SULT1C3.

UniProtKB/Swiss-Prot: ST1E1_HUMAN, P49888
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by
metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also
sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol,
at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated

Gene Wiki entry for SULT1E1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SULT1E1 gene promoter:
         TBP   RFX1   FOXD1   E4BP4   S8   FOXJ2 (long isoform)   FOXJ2   ATF   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSULT1E1 promoter sequence
   Search Chromatin IP Primers for SULT1E1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SULT1E1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.1   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.1

SULT1E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT1E1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M070676:  view genomic region     (about GC identifiers)

Start:
70,676,498 bp from pter      End:
70,725,870 bp from pter
Size:
49,373 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ST1E1_HUMAN, P49888 (See protein sequence)
Recommended Name: Estrogen sulfotransferase  
Size: 294 amino acids; 35126 Da
Subunit: Homodimer
5 PDB 3D structures from and Proteopedia for SULT1E1:
1G3M (3D)        1HY3 (3D)        4JVL (3D)        4JVM (3D)        4JVN (3D)    
Secondary accessions: Q8N6X5

Explore the universe of human proteins at neXtProt for SULT1E1: NX_P49888

Explore proteomics data for SULT1E1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SULT1E1 (P49888) (see all 9)
     ELVDRII  SPFMRKG  FQARPDD  PKSGTTW 


    See SULT1E1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005411.1  
    ENSEMBL proteins: 
     ENSP00000420891   ENSP00000226444  
    Reactome Protein details: P49888

    SULT1E1 Human Recombinant Protein Products:

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    Novus Biologicals SULT1E1 Lysates
    Sino Biological Recombinant Protein for SULT1E1
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    Cloud-Clone Corp. Proteins for SULT1E1

     
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    Search eBioscience for ELISAs for SULT1E1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULT: Sulfotransferases, cytosolic

    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry P49888

    ProtoNet protein and cluster: P49888

    1 Blocks protein domain: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST1E1_HUMAN, P49888
    Similarity: Belongs to the sulfotransferase 1 family


    Find genes that share domains with SULT1E1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST1E1_HUMAN, P49888
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by
    metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also
    sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol,
    at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated
    Catalytic activity: 3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate

         Enzyme Numbers (IUBMB): EC 2.8.2.41 2 EC 2.8.22

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004304estrone sulfotransferase activity IEA--
    GO:0005496steroid binding IEA--
    GO:0008146sulfotransferase activity ----
    GO:0047894flavonol 3-sulfotransferase activity IDA--
    GO:0050294steroid sulfotransferase activity TAS--
         
    Find genes that share ontologies with SULT1E1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sult1e1):
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  reproductive system 

    Find genes that share phenotypes with SULT1E1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sult1e1tm1Song for SULT1E1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SULT1E1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SULT1E1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SULT1E1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SULT1E1:
    hsa-mir-124-3p (MIRT022279), hsa-mir-199a-5p (MIRT007036)

    Block miRNA regulation of human, mouse, rat SULT1E1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SULT1E1
    SwitchGear 3'UTR luciferase reporter plasmidSULT1E1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SULT1E1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SULT1E1 (NM_005420)
    Sino Biological Human cDNA Clone for SULT1E1
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1E1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ST1E1_HUMAN, P49888: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0031965nuclear membrane ----

    Find genes that share ontologies with SULT1E1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SULT1E1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Tamoxifen metabolism0.00
    Phase II conjugation0.56
    Estradiol metabolism0.00
    metapathway biotransformation0.42
    Tamoxifen Pathway, Pharmacokinetics0.00
    Cytosolic sulfonation of small molecules0.00
    2Estrogen metabolism
    Estrogen metabolism0.43
    Estrogen Metabolism Pathway0.43
    3Estrone metabolism
    Estrone metabolism0.57
    Androstenedione and testosterone biosynthesis and metabolism p.10.57
    4Metabolism
    Metabolism0.38
    5Sulfation Biotransformation Reaction
    Sulfation Biotransformation Reaction


    Find genes that share SuperPaths with SULT1E1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for SULT1E1
        Estradiol metabolism
    Estrone metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.1

    4 BioSystems Pathways for SULT1E1
        Sulfation Biotransformation Reaction
    Tamoxifen metabolism
    Estrogen metabolism
    metapathway biotransformation


    1 Reactome Pathway for SULT1E1
        Cytosolic sulfonation of small molecules

    4 PharmGKB Pathways for SULT1E1
        Acetaminophen Pathway, Pharmacokinetics
    Aromatase Inhibitor Pathway (Multiple Tissues), Pharmacodynamics
    Estrogen Metabolism Pathway
    Tamoxifen Pathway, Pharmacokinetics

    1 Kegg Pathway  (Kegg details for SULT1E1):
        Steroid hormone biosynthesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SULT1E1: 
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SULT1E1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SULT1E1 (P498882, 3 ENSP000002264444) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C14orf1Q9UKR52, 3MINT-63808 I2D: score=5 
    COPS6Q7L5N12, 3MINT-63804 I2D: score=5 
    SETDB1Q150472, 3MINT-63802 I2D: score=5 
    TP53P046372, 3MINT-63800 I2D: score=5 
    UNC119Q134322, 3MINT-63801 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007565female pregnancy IEA--
    GO:0008202steroid metabolic process TAS8185618
    GO:0008210estrogen metabolic process IDA11884392
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with SULT1E1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SULT1E1 (ST1E1)

    7 HMDB Compounds for SULT1E1    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone sulfatecatecholestrogen sulfate;2,3-dihydroxyestra-1,3,5(10)-trien-17one 3-sulfate;1,3,5(10)-triene-2,3-diol-17one 3-sulfate;2HEn-3S 1240-04-6--
    4-Hydroxyestrone sulfate1,3,5(10)-triene-3,4-diol-17one 3-sulfate;3,4-dihydroxyestra-1,3,5(10)-trien-17one 3-sulfate;4HEn-3S ----
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Estrone(+)-Estrone (see all 7)53-16-7--
    Estrone sulfateConestoral (see all 12)481-97-0--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--
    Testosterone(+)-testosterone (see all 86)58-22-0--

    5 DrugBank Compounds for SULT1E1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3,5,3',5'-Tetrachloro-Biphenyl-4,4'-Diol-- --target--17139284 17016423 10592235
    Adenosine-3'-5'-Diphosphate-- --target--17139284 17016423 10592235
    3'-Phosphate-Adenosine-5'-Phosphate Sulfate-- --target--17139284 17016423
    AcetaminophenAcetaminofen (see all 5)103-90-2enzymesubstrate18232020
    CyclizineCiclizina [INN-Spanish] (see all 4)82-92-8targetinhibitor1397064

    Selected Novoseek inferred chemical compound relationships for SULT1E1 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1-hydroxyethylpyrene 89.6 2 9636676 (1), 9566749 (1)
    3-phosphoadenosine 5'-phosphosulfate 89.2 19 11884392 (2), 9495883 (1), 10659700 (1), 9348232 (1) (see all 9)
    17beta-hydroxysteroid 87.2 27 14979917 (3), 17933521 (1), 19075592 (1), 12459709 (1) (see all 15)
    3'-phosphoadenosine 5'-phosphate 86.5 1 10854859 (1)
    hydroxysteroid 86.1 6 8033246 (1), 9636676 (1), 11172807 (1), 9068609 (1)
    2,6-dichloro-4-nitrophenol 86 6 8185618 (1), 9667746 (1), 1582375 (1)
    estrone 85.5 34 8943792 (2), 2212823 (2), 9855023 (2), 19131519 (1) (see all 19)
    estrogen 84.5 470 9655902 (7), 15355916 (7), 10659700 (5), 7750469 (5) (see all 99)
    estrone sulfate 84.2 12 8943792 (1), 16755106 (1), 2212823 (1), 18663016 (1) (see all 7)
    nomegestrol acetate 83.6 2 14981909 (2)



    Find genes that share compounds with SULT1E1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SULT1E1 gene: 
    NM_005420.2  

    Unigene Cluster for SULT1E1:

    Sulfotransferase family 1E, estrogen-preferring, member 1
    Hs.479898  [show with all ESTs]
    Unigene Representative Sequence: BC027956
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506796 ENST00000226444(uc003heo.3) ENST00000504002(uc010ihv.1)

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      QuantiTect SYBR Green Assays in human, mouse, rat SULT1E1
      QuantiFast Probe-based Assays in human, mouse, rat SULT1E1

    Additional mRNA sequence: 

    AK310845.1 AK312236.1 BC027956.1 CR407621.1 S77383.1 U08098.1 U55764.1 Y11195.1 

    4 DOTS entries:

    DT.85105493  DT.97815868  DT.100668703  DT.91757474 

    Selected AceView cDNA sequences (see all 66):

    AL700104 AA334154 CB243762 U55764 BX104997 NM_005420 AI376700 U08098 
    AI375444 CR407621 BX495003 H50684 AL699923 BC027956 AI333988 BM972763 
    BU682318 T82255 R96341 W38462 H60426 BM974692 BX481535 BX483192 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SULT1E1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                                        
    SP2:                                                        -               
    SP3:                                            -                           


    ECgene alternative splicing isoforms for SULT1E1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SULT1E1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SULT1E1 Expression
    About this image


    SULT1E1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipocytes Visceral White Adipose
             Visceral White Adipose
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Sertoli cells Seminiferous Tubules
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
    SULT1E1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SULT1E1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479898

    UniProtKB/Swiss-Prot: ST1E1_HUMAN, P49888
    Tissue specificity: Liver, intestine and at lower level in the kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SULT1E1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SULT1E1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sult1e11 , 5 sulfotransferase family 1E, member 11, 5 80.28(n)1
    77.51(a)1
      5 (43.56 cM)5
    208601  NM_023135.21  NP_075624.21 
     875759685 
    chicken
    (Gallus gallus)
    Aves SULT1E16
    sulfotransferase family 1E, estrogen-preferring, m...
    53(a)
    1 ↔ 1
    4(51214007-51215578)
    fruit fly
    (Drosophila melanogaster)
    Insecta St21 Sulfotransferase 2 43.98(n)
    30.8(a)
      41098  NM_141613.2  NP_649870.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SOT121 SOT12 48.12(n)
    33.87(a)
      814903  NM_126423.3  NP_178471.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06266001 Os06g0626600 42.44(n)
    36.97(a)
      4341575  NM_001064653.1  NP_001058118.1 


    ENSEMBL Gene Tree for SULT1E1 (if available)
    TreeFam Gene Tree for SULT1E1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SULT1E1 gene
    SULT1C32  SULT4A12  SULT1B12  SULT1A22  SULT1C42  SULT1C22  SULT2B12  SULT1A42  
    SULT2A12  SULT6B12  SULT1A12  SULT1A32  
    14 SIMAP similar genes for SULT1E1 using alignment to 3 protein entries:     ST1E1_HUMAN (see all proteins):
    STP1    SULT1A4    ST1A5    SULT1B1    SULT1C3    SULT1A1
    SULT1A3    SULT1C2    SULT1A2    SULT1C4    SULT2B1    SULT2A1
    SULT6B1    SULT4A1

    Find genes that share paralogs with SULT1E1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SULT1E1 (see all 477)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425599011,2
    --70706493(+) GGCGCA/GGTGGC 1 -- ds50010--------
    rs1114785661,2
    C,F--70706502(+) GCTCAC/TGCCTG 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1885677131,2
    --70706569(+) ACCATC/TCTGGC 1 -- ds50010--------
    rs1920911261,2
    C--70706632(+) GGTGGC/TGGCCG 1 -- ds50010--------
    rs791481451,2
    C--70706714(+) AGCATG/TAGCAG 1 -- ds50010--------
    rs573318071,2
    C,F--70706764(+) GACTCC/TGTCTC 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1893540031,2
    --70706765(+) ACTCCG/TTCTCA 1 -- ds50010--------
    rs774236341,2
    C--70706815(+) AGCTAT/CAGTTA 1 -- ds50014Minor allele frequency- C:0.06CSA WA NA EA 359
    rs115738011,2
    C,F,H--70706991(-) TGATGT/CAGTAA 1 -- ut317Minor allele frequency- C:0.01NS EA NA 600
    rs115738001,2
    C,H--70707005(-) ATAACC/GTATGG 1 -- ut31 ese35Minor allele frequency- G:0.00NS EA 596

    HapMap Linkage Disequilibrium report for SULT1E1 (70676498 - 70725870 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SULT1E1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5627n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): SULT1E1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SULT1E1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600043    OMIM disorders: --

    3 diseases for SULT1E1:    
    About MalaCards
    endometrial adenocarcinoma    endometrial stromal sarcoma    endometrial carcinoma

    1 disease from the University of Copenhagen DISEASES database for SULT1E1:
    Breast cancer

    Find genes that share disorders with SULT1E1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SULT1E1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 57 45 14642074 (3), 15522178 (3), 17661084 (2), 1580921 (2) (see all 21)
    breast carcinoma 49.8 27 12782580 (7), 14623543 (4), 19250194 (2), 9655902 (1) (see all 8)
    endometrial cancer 46.9 14 18318428 (3), 19250196 (2), 17197118 (1), 19022235 (1)
    endometrial carcinoma 36.1 8 15355916 (4), 8625916 (1), 14556660 (1), 16857224 (1)
    carcinoma ductal 34.1 1 12782580 (1)
    breast diseases 33.6 1 19308726 (1)
    carcinoma 21.3 13 19250194 (2), 12782580 (2), 15355916 (1), 14623543 (1) (see all 5)
    tumors 7.62 16 16166425 (2), 17197118 (2), 19159687 (1), 19250194 (1) (see all 9)
    cancer 4.05 7 1391981 (2), 19250196 (1), 16303840 (1), 16541422 (1)
    adenocarcinoma 0 3 8187949 (1), 16857224 (1)

    Genetic Association Database (GAD): SULT1E1
    Human Genome Epidemiology (HuGE) Navigator: SULT1E1 (17 documents)

    Export disorders for SULT1E1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SULT1E1 gene, integrated from 10 sources (see all 194):
    (articles sorted by number of sources associating them with SULT1E1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization. (PubMed id 8530066)1, 2, 9 Her C....Weinshilboum R.M. (Genomics 1995)
    2. SULT1E1 genetic polymorphisms modified the association between phytoestrogen consumption and bone mineral density in healthy Korean women. (PubMed id 16969590)1, 4, 9 Lee S.A....Kang D. (Calcif. Tissue Int. 2006)
    3. Human liver estrogen sulfotransferase: identification by cDNA cloning and expression. (PubMed id 8185618)1, 2, 9 Aksoy I.A.... Weinshilboum R.M. (Biochem. Biophys. Res. Commun. 1994)
    4. CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility. (PubMed id 18318428)1, 4, 9 Hirata H....Dahiya R. (Cancer 2008)
    5. Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer. (PubMed id 19551860)1, 4, 9 Udler M.S....Pharoah P.D. (Int. J. Cancer 2009)
    6. Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase. (PubMed id 12782487)1, 2, 9 Shevtsov S.... Negishi M. (Environ. Health Perspect. 2003)
    7. Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. (PubMed id 11884392)1, 2, 9 Pedersen L.C.... Negishi M. (J. Biol. Chem. 2002)
    8. Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States. (PubMed id 20142249)1, 4, 9 Yong M....Lampe J.W. (amp 2010)
    9. Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes. (PubMed id 19776291)1, 4, 9 Ferlin A....Foresta C. (Endocr. Relat. Cancer 2010)
    10. Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer risk. (PubMed id 16985250)1, 4, 9 Rebbeck T.R....Strom B.L. (J. Natl. Cancer Inst. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6783 HGNC: 11377 AceView: SULT1E1 Ensembl:ENSG00000109193 euGenes: HUgn6783
    ECgene: SULT1E1 Kegg: 6783 H-InvDB: SULT1E1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SULT1E1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SULT1E1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ste/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SULT1E1 gene:
    Search GeneIP for patents involving SULT1E1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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