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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SULT1E1 Gene

protein-coding   GIFtS: 68
GCID: GC04M070676

Sulfotransferase Family 1E, Estrogen-Preferring, Member...

(Previous names: sulfotransferase, estrogen-preferring)
(Previous symbol: STE)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sulfotransferase Family 1E, Estrogen-Preferring, Member 11 2     EC 2.8.2.43 8
STE1 2 3 5     EST2 5
Sulfotransferase, Estrogen-Preferring1 2 3     Estrogen Sulfotransferase2
Sulfotransferase 1E12 3     Estrone Sulfotransferase2
EST-12 3     EC 2.8.28
ST1E12 3     

External Ids:    HGNC: 113771   Entrez Gene: 67832   Ensembl: ENSG000001091937   OMIM: 6000435   UniProtKB: P498883   

Export aliases for SULT1E1 gene to outside databases

Previous GC identifers: GC04M071022 GC04M070887 GC04M070741 GC04M066504


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SULT1E1 Gene:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and
xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate
specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes
a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SULT1E1 Gene: 
SULT1E1 (sulfotransferase family 1E, estrogen-preferring, member 1) is a protein-coding gene. Diseases associated with SULT1E1 include endometrial stromal sarcoma, and endometrial adenocarcinoma, and among its related super-pathways are Tamoxifen Pathway, Pharmacokinetics and Phase II conjugation. GO annotations related to this gene include steroid sulfotransferase activity and steroid binding. An important paralog of this gene is SULT1C3.

UniProtKB/Swiss-Prot: ST1E1_HUMAN, P49888
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by
metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also
sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol,
at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated

Gene Wiki entry for SULT1E1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SULT1E1 gene promoter:
         TBP   RFX1   FOXD1   E4BP4   S8   FOXJ2 (long isoform)   FOXJ2   ATF   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSULT1E1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SULT1E1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULT1E1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.1   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.1

SULT1E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT1E1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M070676:  view genomic region     (about GC identifiers)

Start:
70,676,498 bp from pter      End:
70,725,870 bp from pter
Size:
49,373 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ST1E1_HUMAN, P49888 (See protein sequence)
Recommended Name: Estrogen sulfotransferase  
Size: 294 amino acids; 35126 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
2 PDB 3D structures from and Proteopedia for SULT1E1:
1G3M (3D)        1HY3 (3D)    
Secondary accessions: Q8N6X5

Explore the universe of human proteins at neXtProt for SULT1E1: NX_P49888

Explore proteomics data for SULT1E1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49888

  • 4/9 DME Specific Peptides for SULT1E1 (P49888) (see all 9)
     ELVDRII  SPFMRKG  FQARPDD  PKSGTTW 

    SULT1E1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SULT1E1 Protein Expression
    REFSEQ proteins: NP_005411.1  
    ENSEMBL proteins: 
     ENSP00000420891   ENSP00000226444  
    Reactome Protein details: P49888
    Human Recombinant Protein Products for SULT1E1: 
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    Novus Biologicals SULT1E1 Proteins
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    ProSpec Recombinant Protein for SULT1E1
    Cloud-Clone Corp. Proteins for SULT1E1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0031965nuclear membrane IDA--

    SULT1E1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SULT: Sulfotransferases, cytosolic

    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry P49888

    ProtoNet protein and cluster: P49888

    1 Blocks protein domain: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST1E1_HUMAN, P49888
    Similarity: Belongs to the sulfotransferase 1 family


    SULT1E1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST1E1_HUMAN, P49888
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by
    metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also
    sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol,
    at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated
    Catalytic activity: 3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate

         Enzyme Numbers (IUBMB): EC 2.8.2.41 2 EC 2.8.22

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004304estrone sulfotransferase activity IEA--
    GO:0005496steroid binding IEA--
    GO:0008146sulfotransferase activity ----
    GO:0047894flavonol 3-sulfotransferase activity IDA--
    GO:0050294steroid sulfotransferase activity TAS--
         
    SULT1E1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sult1e1):
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  reproductive system 

    SULT1E1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sult1e1tm1Song for SULT1E1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SULT1E1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SULT1E1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SULT1E1 

    miRNA
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    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1E1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SULT1E1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Tamoxifen metabolism
    Tamoxifen metabolism0.68
    Estradiol metabolism0.52
    Tamoxifen Pathway, Pharmacokinetics0.68
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    3Cytosolic sulfonation of small molecules
    Cytosolic sulfonation of small molecules0.52
    Sulfation Biotransformation Reaction0.52
    4Estrogen metabolism
    Estrogen Metabolism Pathway0.43
    Estrogen metabolism0.43
    5Estrone metabolism
    Estrone metabolism0.57
    Androstenedione and testosterone biosynthesis and metabolism p.10.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for SULT1E1
        Androstenedione and testosterone biosynthesis and metabolism p.1
    Estradiol metabolism
    Estrone metabolism


    3 GeneGo (Thomson Reuters) Pathways for SULT1E1
        Estradiol metabolism
    Estrone metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.1

    4 BioSystems Pathways for SULT1E1
        Sulfation Biotransformation Reaction
    Tamoxifen metabolism
    Estrogen metabolism
    metapathway biotransformation


    4        Reactome Pathways for SULT1E1
        Metabolism
    Biological oxidations
    Cytosolic sulfonation of small molecules
    Phase II conjugation

    4 PharmGKB Pathways for SULT1E1
        Acetaminophen Pathway, Pharmacokinetics
    Aromatase Inhibitor Pathway (Multiple Tissues), Pharmacodynamics
    Estrogen Metabolism Pathway
    Tamoxifen Pathway, Pharmacokinetics

    1         Kegg Pathway  (Kegg details for SULT1E1):
        Steroid hormone biosynthesis


    SULT1E1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SULT1E1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/50 Interacting proteins for SULT1E1 (P498882, 3 ENSP000002264444) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C14orf1Q9UKR52, 3MINT-63808 I2D: score=5 
    COPS6Q7L5N12, 3MINT-63804 I2D: score=5 
    SETDB1Q150472, 3MINT-63802 I2D: score=5 
    TP53P046372, 3MINT-63800 I2D: score=5 
    UNC119Q134322, 3MINT-63801 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007565female pregnancy IEA--
    GO:0008202steroid metabolic process TAS8185618
    GO:0008210estrogen metabolic process IDA11884392
    GO:0044281small molecule metabolic process TAS--

    SULT1E1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SULT1E1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SULT1E1 (ST1E1)

    7 HMDB Compounds for SULT1E1    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hydroxyestrone sulfatecatecholestrogen sulfate;2,3-dihydroxyestra-1,3,5(10)-trien-17one 3-sulfate;1,3,5(10)-triene-2,3-diol-17one 3-sulfate;2HEn-3S 1240-04-6--
    4-Hydroxyestrone sulfate1,3,5(10)-triene-3,4-diol-17one 3-sulfate;3,4-dihydroxyestra-1,3,5(10)-trien-17one 3-sulfate;4HEn-3S ----
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Estrone(+)-Estrone (see all 7)53-16-7--
    Estrone sulfateConestoral (see all 12)481-97-0--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--
    Testosterone(+)-testosterone (see all 86)58-22-0--

    5 DrugBank Compounds for SULT1E1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3,5,3',5'-Tetrachloro-Biphenyl-4,4'-Diol-- --target--17139284 17016423 10592235
    Adenosine-3'-5'-Diphosphate-- --target--17139284 17016423 10592235
    3'-Phosphate-Adenosine-5'-Phosphate Sulfate-- --target--17139284 17016423
    AcetaminophenAcetaminofen (see all 5)103-90-2enzymesubstrate18232020
    CyclizineCiclizina [INN-Spanish] (see all 4)82-92-8targetinhibitor1397064

    10/36 Novoseek inferred chemical compound relationships for SULT1E1 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1-hydroxyethylpyrene 89.6 2 9636676 (1), 9566749 (1)
    3-phosphoadenosine 5'-phosphosulfate 89.2 19 11884392 (2), 9495883 (1), 10659700 (1), 9348232 (1) (see all 9)
    17beta-hydroxysteroid 87.2 27 14979917 (3), 17933521 (1), 19075592 (1), 12459709 (1) (see all 15)
    3'-phosphoadenosine 5'-phosphate 86.5 1 10854859 (1)
    hydroxysteroid 86.1 6 8033246 (1), 9636676 (1), 11172807 (1), 9068609 (1)
    2,6-dichloro-4-nitrophenol 86 6 8185618 (1), 9667746 (1), 1582375 (1)
    estrone 85.5 34 8943792 (2), 2212823 (2), 9855023 (2), 19131519 (1) (see all 19)
    estrogen 84.5 470 9655902 (7), 15355916 (7), 10659700 (5), 7750469 (5) (see all 99)
    estrone sulfate 84.2 12 8943792 (1), 16755106 (1), 2212823 (1), 18663016 (1) (see all 7)
    nomegestrol acetate 83.6 2 14981909 (2)

    Search CenterWatch for drugs/clinical trials and news about SULT1E1 / ST1E1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SULT1E1 gene: 
    NM_005420.2  

    Unigene Cluster for SULT1E1:

    Sulfotransferase family 1E, estrogen-preferring, member 1
    Hs.479898  [show with all ESTs]
    Unigene Representative Sequence: BC027956
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506796 ENST00000226444(uc003heo.3) ENST00000504002(uc010ihv.1)

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    Additional mRNA sequence: 

    AK310845.1 AK312236.1 BC027956.1 CR407621.1 S77383.1 U08098.1 U55764.1 Y11195.1 

    4 DOTS entries:

    DT.85105493  DT.97815868  DT.100668703  DT.91757474 

    24/66 AceView cDNA sequences (see all 66):

    CR407621 U55764 NM_005420 U08098 AI376700 BX495003 CB243762 AL700104 
    AI375444 AA334154 BX104997 BM972763 BU681416 BU682318 H50779 R96341 
    BX481535 AI333988 BX483192 BM745104 BC027956 AI273634 BU682336 AW950477 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SULT1E1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                                        
    SP2:                                                        -               
    SP3:                                            -                           


    ECgene alternative splicing isoforms for SULT1E1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SULT1E1 expression in normal human tissues (normalized intensities)      SULT1E1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SULT1E1 Expression
    About this image


    SULT1E1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/nasal cavity   
     
     Heart (Cardiovascular System)
             Cardiac Myocytes   
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose

    See SULT1E1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SULT1E1

    SOURCE GeneReport for Unigene cluster: Hs.479898

    UniProtKB/Swiss-Prot: ST1E1_HUMAN, P49888
    Tissue specificity: Liver, intestine and at lower level in the kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including SULT1E1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SULT1E1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sult1e11 , 5 sulfotransferase family 1E, member 11, 5 80.28(n)1
    77.51(a)1
      5 (43.56 cM)5
    208601  NM_023135.21  NP_075624.21 
     875759685 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    possible ortholog
    GL343287.1(813742-831410)
    zebrafish
    (Danio rerio)
    Actinopterygii sult1st56
    sult1st66
    sulfotransferase family 1, cytosolic sulfotransfer...
    sulfotransferase family 1, cytosolic sulfotransfer...
    44(a)
    39(a)
    possible ortholog
    possible ortholog
    23(24776416-24781150)
    12(16077368-16084598)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG167331 CG16733 44.61(n)
    30.8(a)
      41098  NM_141613.1  NP_649870.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SOT121 flavonol sulfotransferase-like protein 48.24(n)
    34.15(a)
      814903  NM_126423.3  NP_178471.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g02709001 hypothetical protein 46.83(n)
    36.59(a)
      4351955  NM_001073082.1  NP_001066550.1 


    ENSEMBL Gene Tree for SULT1E1 (if available)
    TreeFam Gene Tree for SULT1E1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SULT1E1 gene
    SULT1C32  SULT4A12  SULT1B12  SULT1A22  SULT1C42  SULT1C22  SULT2B12  SULT1A42  
    SULT2A12  SULT6B12  SULT1A12  SULT1A32  
    14 SIMAP similar genes for SULT1E1 using alignment to 3 protein entries:     ST1E1_HUMAN (see all proteins):
    STP1    SULT1A4    SULT1B1    ST1A5    SULT1C3    SULT1A1
    SULT1A3    SULT1C2    SULT1A2    SULT1C4    SULT2B1    SULT2A1
    SULT6B1    SULT4A1

    SULT1E1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/477 SNPs in SULT1E1 are shown (see all 477)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425599011,2
    --70706493(+) GGCGCA/GGTGGC 1 -- ds50010--------
    rs1114785661,2
    C,F--70706502(+) GCTCAC/TGCCTG 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1885677131,2
    --70706569(+) ACCATC/TCTGGC 1 -- ds50010--------
    rs1920911261,2
    C--70706632(+) GGTGGC/TGGCCG 1 -- ds50010--------
    rs791481451,2
    C--70706714(+) AGCATG/TAGCAG 1 -- ds50010--------
    rs573318071,2
    C,F--70706764(+) GACTCC/TGTCTC 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1893540031,2
    --70706765(+) ACTCCG/TTCTCA 1 -- ds50010--------
    rs774236341,2
    C--70706815(+) AGCTAT/CAGTTA 1 -- ds50014Minor allele frequency- C:0.06CSA WA NA EA 359
    rs115738011,2
    C,F,H--70706991(-) TGATGT/CAGTAA 1 -- ut317Minor allele frequency- C:0.01NS EA NA 600
    rs115738001,2
    C,H--70707005(-) ATAACC/GTATGG 1 -- ut31 ese35Minor allele frequency- G:0.00NS EA 596

    HapMap Linkage Disequilibrium report for SULT1E1 (70676498 - 70725870 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SULT1E1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv5627n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): SULT1E1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600043    OMIM disorders: --

    20/24 diseases for SULT1E1 (see all 24):    About MalaCards
    endometrial stromal sarcoma    endometrial adenocarcinoma    breast disease    endometrial carcinoma
    birth defects    cholelithiasis    thymoma    epididymitis
    germ cell tumors    leiomyoma    endometriosis    cytochrome p450
    thrombosis    cystic fibrosis    adenocarcinoma    sarcoma
    atherosclerosis    breast cancer    obesity    alcoholism

    1 disease from the University of Copenhagen DISEASES database for SULT1E1:
    Breast cancer

    SULT1E1 for disorders           About GeneDecksing

    10/11 Novoseek inferred disease relationships for SULT1E1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 57 45 14642074 (3), 15522178 (3), 17661084 (2), 1580921 (2) (see all 21)
    breast carcinoma 49.8 27 12782580 (7), 14623543 (4), 19250194 (2), 9655902 (1) (see all 8)
    endometrial cancer 46.9 14 18318428 (3), 19250196 (2), 17197118 (1), 19022235 (1)
    endometrial carcinoma 36.1 8 15355916 (4), 8625916 (1), 14556660 (1), 16857224 (1)
    carcinoma ductal 34.1 1 12782580 (1)
    breast diseases 33.6 1 19308726 (1)
    carcinoma 21.3 13 19250194 (2), 12782580 (2), 15355916 (1), 14623543 (1) (see all 5)
    tumors 7.62 16 16166425 (2), 17197118 (2), 19159687 (1), 19250194 (1) (see all 9)
    cancer 4.05 7 1391981 (2), 19250196 (1), 16303840 (1), 16541422 (1)
    adenocarcinoma 0 3 8187949 (1), 16857224 (1)

    Genetic Association Database (GAD): SULT1E1
    Human Genome Epidemiology (HuGE) Navigator: SULT1E1 (17 documents)

    Export disorders for SULT1E1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SULT1E1 gene, integrated from 9 sources (see all 194):
    (articles sorted by number of sources associating them with SULT1E1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization. (PubMed id 8530066)1, 2, 9 Her C....Weinshilboum R.M. (1995)
    2. SULT1E1 genetic polymorphisms modified the association between phytoestrogen consumption and bone mineral density in healthy Korean women. (PubMed id 16969590)1, 4, 9 Lee S.A....Kang D. (2006)
    3. Human liver estrogen sulfotransferase: identification by cDNA cloning and expression. (PubMed id 8185618)1, 2, 9 Aksoy I.A.... Weinshilboum R.M. (1994)
    4. CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility. (PubMed id 18318428)1, 4, 9 Hirata H....Dahiya R. (2008)
    5. Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer. (PubMed id 19551860)1, 4, 9 Udler M.S....Pharoah P.D. (2009)
    6. Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase. (PubMed id 12782487)1, 2, 9 Shevtsov S.... Negishi M. (2003)
    7. Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. (PubMed id 11884392)1, 2, 9 Pedersen L.C.... Negishi M. (2002)
    8. Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women i n the United States. (PubMed id 20142249)1, 4, 9 Yong M....Lampe J.W. (2010)
    9. Association of testicular germ cell tumor with polymo rphisms in estrogen receptor and steroid metabolism genes. (PubMed id 19776291)1, 4, 9 Ferlin A....Foresta C. (2010)
    10. Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer risk. (PubMed id 16985250)1, 4, 9 Rebbeck T.R....Strom B.L. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6783 HGNC: 11377 AceView: SULT1E1 Ensembl:ENSG00000109193 euGenes: HUgn6783
    ECgene: SULT1E1 Kegg: 6783 H-InvDB: SULT1E1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SULT1E1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SULT1E1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ste/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SULT1E1 gene:
    Search GeneIP for patents involving SULT1E1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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