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Aliases for SULT1E1 Gene

Aliases for SULT1E1 Gene

  • Sulfotransferase Family 1E, Estrogen-Preferring, Member 1 2 3
  • Sulfotransferase, Estrogen-Preferring 2 3 4
  • STE 3 4 6
  • Sulfotransferase 1E1 3 4
  • EC 2.8.2.4 4 64
  • EST-1 3 4
  • ST1E1 3 4
  • EST 3 6
  • Estrogen Sulfotransferase 3
  • Estrone Sulfotransferase 3
  • EC 2.8.2 64

External Ids for SULT1E1 Gene

Previous Symbols for SULT1E1 Gene

  • STE

Summaries for SULT1E1 Gene

Entrez Gene Summary for SULT1E1 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1E1 Gene

SULT1E1 (Sulfotransferase Family 1E, Estrogen-Preferring, Member 1) is a Protein Coding gene. Diseases associated with SULT1E1 include endometrial adenocarcinoma and endometrial cancer. Among its related pathways are Metabolism and Estrogen metabolism. GO annotations related to this gene include steroid binding and steroid sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT1E1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.

Gene Wiki entry for SULT1E1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1E1 Gene

Genomics for SULT1E1 Gene

Genomic Location for SULT1E1 Gene

Start:
69,810,780 bp from pter
End:
69,860,152 bp from pter
Size:
49,373 bases
Orientation:
Minus strand

Genomic View for SULT1E1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SULT1E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1E1 Gene

Regulatory Elements for SULT1E1 Gene

Proteins for SULT1E1 Gene

  • Protein details for SULT1E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49888-ST1E1_HUMAN
    Recommended name:
    Estrogen sulfotransferase
    Protein Accession:
    P49888
    Secondary Accessions:
    • Q8N6X5

    Protein attributes for SULT1E1 Gene

    Size:
    294 amino acids
    Molecular mass:
    35126 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SULT1E1 Gene

neXtProt entry for SULT1E1 Gene

Proteomics data for SULT1E1 Gene at MOPED

Selected DME Specific Peptides for SULT1E1 Gene

Post-translational modifications for SULT1E1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT1E1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SULT1E1 Gene

Gene Families for SULT1E1 Gene

HGNC:
  • SULT :Sulfotransferases, cytosolic

Protein Domains for SULT1E1 Gene

UniProtKB/Swiss-Prot:

ST1E1_HUMAN
Family:
  • Belongs to the sulfotransferase 1 family.:
    • P49888
genes like me logo Genes that share domains with SULT1E1: view

Function for SULT1E1 Gene

Molecular function for SULT1E1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + estrone = adenosine 3,5-bisphosphate + estrone 3-sulfate.
UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.

Enzyme Numbers (IUBMB) for SULT1E1 Gene

Gene Ontology (GO) - Molecular Function for SULT1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004304 estrone sulfotransferase activity IEA --
GO:0005496 steroid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008146 sulfotransferase activity --
GO:0047894 flavonol 3-sulfotransferase activity IDA 20056724
genes like me logo Genes that share ontologies with SULT1E1: view
genes like me logo Genes that share phenotypes with SULT1E1: view

Animal Models for SULT1E1 Gene

MGI Knock Outs for SULT1E1:

miRNA for SULT1E1 Gene

miRTarBase miRNAs that target SULT1E1

No data available for Transcription Factor Targeting and HOMER Transcription for SULT1E1 Gene

Localization for SULT1E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1E1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT1E1 Gene COMPARTMENTS Subcellular localization image for SULT1E1 gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SULT1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT1E1: view

Pathways for SULT1E1 Gene

genes like me logo Genes that share pathways with SULT1E1: view

Gene Ontology (GO) - Biological Process for SULT1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0007565 female pregnancy IEA --
GO:0008202 steroid metabolic process TAS 8185618
GO:0008210 estrogen metabolic process IDA 11884392
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with SULT1E1: view

Compounds for SULT1E1 Gene

(7) HMDB Compounds for SULT1E1 Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxyestrone sulfate
  • catecholestrogen sulfate
1240-04-6
4-Hydroxyestrone sulfate
  • 1,3,5(10)-triene-3,4-diol-17one 3-sulfate
Not Available
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Estrone
  • (+)-Estrone
53-16-7
Estrone sulfate
  • Conestoral
481-97-0

(5) Drugbank Compounds for SULT1E1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3,5,3',5'-Tetrachloro-Biphenyl-4,4'-Diol
target
3'-Phosphate-Adenosine-5'-Phosphate Sulfate
target
Acetaminophen
  • Acetaminofen
103-90-2 enzyme substrate
Adenosine-3'-5'-Diphosphate
target
Cyclizine
  • Ciclizina [INN-Spanish]
82-92-8 target inhibitor

(36) Novoseek inferred chemical compound relationships for SULT1E1 Gene

Compound -log(P) Hits PubMed IDs
1-hydroxyethylpyrene 89.6 2
3-phosphoadenosine 5-phosphosulfate 89.2 10
17beta-hydroxysteroid 87.2 17
3-phosphoadenosine 5-phosphate 86.5 1
hydroxysteroid 86.1 4
genes like me logo Genes that share compounds with SULT1E1: view

Transcripts for SULT1E1 Gene

mRNA/cDNA for SULT1E1 Gene

Unigene Clusters for SULT1E1 Gene

Sulfotransferase family 1E, estrogen-preferring, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1E1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1:
SP2: -
SP3: -

Relevant External Links for SULT1E1 Gene

GeneLoc Exon Structure for
SULT1E1
ECgene alternative splicing isoforms for
SULT1E1

Expression for SULT1E1 Gene

mRNA expression in normal human tissues for SULT1E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT1E1 Gene

This gene is overexpressed in Vagina (11.5), Skin - Sun Exposed (Lower leg) (8.4), Liver (6.1), Adrenal Gland (6.0), Skin - Not Sun Exposed (Suprapubic) (5.7), and Cervix - Ectocervix (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SULT1E1 Gene

SOURCE GeneReport for Unigene cluster for SULT1E1 Gene Hs.479898

mRNA Expression by UniProt/SwissProt for SULT1E1 Gene

P49888-ST1E1_HUMAN
Tissue specificity: Liver, intestine and at lower level in the kidney
genes like me logo Genes that share expressions with SULT1E1: view

Orthologs for SULT1E1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SULT1E1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT1E1 36
  • 99.32 (n)
  • 99.66 (a)
SULT1E1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SULT1E1 36
  • 80.89 (n)
  • 73.04 (a)
SULT1E1 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SULT1E1 36
  • 86.19 (n)
  • 82.88 (a)
SULT1E1 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sult1e1 36
  • 80.28 (n)
  • 77.51 (a)
Sult1e1 16
Sult1e1 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SULT1E1 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia ste2 36
  • 76.82 (n)
  • 71.28 (a)
chicken
(Gallus gallus)
Aves SULT1E1 37
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004498 36
  • 44.61 (n)
  • 32.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta St2 36
  • 43.98 (n)
  • 30.8 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SOT12 36
  • 48.12 (n)
  • 33.87 (a)
rice
(Oryza sativa)
Liliopsida Os06g0626600 36
  • 42.44 (n)
  • 36.97 (a)
Species with no ortholog for SULT1E1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SULT1E1 Gene

ENSEMBL:
Gene Tree for SULT1E1 (if available)
TreeFam:
Gene Tree for SULT1E1 (if available)

Paralogs for SULT1E1 Gene

Selected SIMAP similar genes for SULT1E1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SULT1E1: view

Variants for SULT1E1 Gene

Sequence variations from dbSNP and Humsavar for SULT1E1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1220702 -- 69,847,802(-) TCTCT(C/G)TAATT intron-variant
rs1220703 -- 69,846,443(-) CTAAA(A/T)ATACA intron-variant
rs1220704 -- 69,845,810(-) TGACA(G/T)TGAAT intron-variant
rs1220715 -- 69,850,909(+) TACAT(G/T)CTCAT intron-variant
rs1220716 -- 69,853,259(+) TTTTC(C/T)CTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULT1E1 Gene

Variant ID Type Subtype PubMed ID
dgv5627n71 CNV Loss 21882294

Relevant External Links for SULT1E1 Gene

HapMap Linkage Disequilibrium report
SULT1E1
Human Gene Mutation Database (HGMD)
SULT1E1

Disorders for SULT1E1 Gene

(1) University of Copenhagen DISEASES for SULT1E1 Gene

(11) Novoseek inferred disease relationships for SULT1E1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 57 31
breast carcinoma 49.8 18
endometrial cancer 46.9 7
endometrial carcinoma 36.1 7
carcinoma ductal 34.1 1

Relevant External Links for SULT1E1

Genetic Association Database (GAD)
SULT1E1
Human Genome Epidemiology (HuGE) Navigator
SULT1E1
genes like me logo Genes that share disorders with SULT1E1: view

No data available for UniProtKB/Swiss-Prot for SULT1E1 Gene

Publications for SULT1E1 Gene

  1. Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase. (PMID: 7779757) Falany C.N. … Falany J.L. (J. Steroid Biochem. Mol. Biol. 1995) 3 4 23
  2. Human liver estrogen sulfotransferase: identification by cDNA cloning and expression. (PMID: 8185618) Aksoy I.A. … Weinshilboum R.M. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  3. Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization. (PMID: 8530066) Her C. … Weinshilboum R.M. (Genomics 1995) 3 4 23
  4. Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. (PMID: 11884392) Pedersen L.C. … Negishi M. (J. Biol. Chem. 2002) 3 4 23
  5. SULT1E1 genetic polymorphisms modified the association between phytoestrogen consumption and bone mineral density in healthy Korean women. (PMID: 16969590) Lee S.A. … Kang D. (Calcif. Tissue Int. 2006) 3 23 49

Products for SULT1E1 Gene

Sources for SULT1E1 Gene

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