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Aliases for SULT1E1 Gene

Aliases for SULT1E1 Gene

  • Sulfotransferase Family 1E Member 1 2 3 5
  • Sulfotransferase, Estrogen-Preferring 2 3 4
  • Sulfotransferase Family 1E, Estrogen-Preferring, Member 1 2 3
  • Sulfotransferase 1E1 3 4
  • EC 2.8.2.4 4 63
  • EST-1 3 4
  • ST1E1 3 4
  • STE 3 4
  • Estrone Sulfotransferase 3
  • EC 2.8.2 63
  • EST 3

External Ids for SULT1E1 Gene

Previous HGNC Symbols for SULT1E1 Gene

  • STE

Previous GeneCards Identifiers for SULT1E1 Gene

  • GC04M071022
  • GC04M070887
  • GC04M070741
  • GC04M066504
  • GC04M070676

Summaries for SULT1E1 Gene

Entrez Gene Summary for SULT1E1 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1E1 Gene

SULT1E1 (Sulfotransferase Family 1E Member 1) is a Protein Coding gene. Diseases associated with SULT1E1 include anteroseptal myocardial infarction and inferior myocardial infarction. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include sulfotransferase activity and flavonol 3-sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT1E1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.

Gene Wiki entry for SULT1E1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1E1 Gene

Genomics for SULT1E1 Gene

Regulatory Elements for SULT1E1 Gene

Genomic Location for SULT1E1 Gene

Chromosome:
4
Start:
69,810,780 bp from pter
End:
69,860,765 bp from pter
Size:
49,986 bases
Orientation:
Minus strand

Genomic View for SULT1E1 Gene

Genes around SULT1E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1E1 Gene

Proteins for SULT1E1 Gene

  • Protein details for SULT1E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49888-ST1E1_HUMAN
    Recommended name:
    Estrogen sulfotransferase
    Protein Accession:
    P49888
    Secondary Accessions:
    • Q8N6X5

    Protein attributes for SULT1E1 Gene

    Size:
    294 amino acids
    Molecular mass:
    35126 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SULT1E1 Gene

neXtProt entry for SULT1E1 Gene

Proteomics data for SULT1E1 Gene at MOPED

Selected DME Specific Peptides for SULT1E1 Gene

Post-translational modifications for SULT1E1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT1E1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SULT1E1 (Cytosolic Sulfotransferase 1E1/SULT1E1)

Domains & Families for SULT1E1 Gene

Gene Families for SULT1E1 Gene

Protein Domains for SULT1E1 Gene

Suggested Antigen Peptide Sequences for SULT1E1 Gene

Graphical View of Domain Structure for InterPro Entry

P49888

UniProtKB/Swiss-Prot:

ST1E1_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1E1: view

Function for SULT1E1 Gene

Molecular function for SULT1E1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + estrone = adenosine 3,5-bisphosphate + estrone 3-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.

Enzyme Numbers (IUBMB) for SULT1E1 Gene

Gene Ontology (GO) - Molecular Function for SULT1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004304 estrone sulfotransferase activity TAS --
GO:0050294 steroid sulfotransferase activity TAS --
genes like me logo Genes that share ontologies with SULT1E1: view
genes like me logo Genes that share phenotypes with SULT1E1: view

Animal Models for SULT1E1 Gene

MGI Knock Outs for SULT1E1:

Animal Model Products

CRISPR Products

miRNA for SULT1E1 Gene

miRTarBase miRNAs that target SULT1E1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SULT1E1 Gene

Localization for SULT1E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1E1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT1E1 Gene COMPARTMENTS Subcellular localization image for SULT1E1 gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SULT1E1 Gene

Pathways & Interactions for SULT1E1 Gene

genes like me logo Genes that share pathways with SULT1E1: view

Gene Ontology (GO) - Biological Process for SULT1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0045600 positive regulation of fat cell differentiation IMP 24567372
genes like me logo Genes that share ontologies with SULT1E1: view

No data available for SIGNOR curated interactions for SULT1E1 Gene

Drugs & Compounds for SULT1E1 Gene

(25) Drugs for SULT1E1 Gene - From: Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclizine Approved Pharma Target, inhibitor 0
Acetaminophen Approved Pharma Enzyme, substrate 864
Estrone Approved Pharma Agonist Estrogenic hormone 19
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 474
3,5,3',5'-Tetrachloro-Biphenyl-4,4'-Diol Experimental Pharma Target 0

(17) Additional Compounds for SULT1E1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
estrone sulfate
  • Conestoral
  • Estrogenic substances
  • Estrone
  • Estrone hydrogen sulfate
  • Estrone hydrogen sulphate
481-97-0
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with SULT1E1: view

Transcripts for SULT1E1 Gene

mRNA/cDNA for SULT1E1 Gene

Unigene Clusters for SULT1E1 Gene

Sulfotransferase family 1E, estrogen-preferring, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1E1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1:
SP2: -
SP3: -

Relevant External Links for SULT1E1 Gene

GeneLoc Exon Structure for
SULT1E1
ECgene alternative splicing isoforms for
SULT1E1

Expression for SULT1E1 Gene

mRNA expression in normal human tissues for SULT1E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT1E1 Gene

This gene is overexpressed in Vagina (x11.5), Skin - Sun Exposed (Lower leg) (x8.4), Liver (x6.1), Adrenal Gland (x6.0), Skin - Not Sun Exposed (Suprapubic) (x5.7), and Cervix - Ectocervix (x5.5).

Protein differential expression in normal tissues from HIPED for SULT1E1 Gene

This gene is overexpressed in Fetal Liver (18.2), Fetal gut (14.2), Fetal testis (12.0), Fetal ovary (8.6), Gallbladder (6.6), and Fetal heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SULT1E1 Gene



SOURCE GeneReport for Unigene cluster for SULT1E1 Gene Hs.479898

mRNA Expression by UniProt/SwissProt for SULT1E1 Gene

P49888-ST1E1_HUMAN
Tissue specificity: Liver, intestine and at lower level in the kidney.
genes like me logo Genes that share expression patterns with SULT1E1: view

Protein tissue co-expression partners for SULT1E1 Gene

Primer Products

In Situ Assay Products

Orthologs for SULT1E1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SULT1E1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SULT1E1 35
  • 80.89 (n)
  • 73.04 (a)
SULT1E1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SULT1E1 35
  • 86.19 (n)
  • 82.88 (a)
SULT1E1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sult1e1 35
  • 80.28 (n)
  • 77.51 (a)
Sult1e1 16
Sult1e1 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SULT1E1 35
  • 99.32 (n)
  • 99.66 (a)
SULT1E1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia ste2 35
  • 76.82 (n)
  • 71.28 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SULT1E1 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves SULT1E1 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004498 35
  • 44.61 (n)
  • 32.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta St2 35
  • 43.98 (n)
  • 30.8 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SOT12 35
  • 48.12 (n)
  • 33.87 (a)
rice
(Oryza sativa)
Liliopsida Os06g0626600 35
  • 42.44 (n)
  • 36.97 (a)
Species with no ortholog for SULT1E1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SULT1E1 Gene

ENSEMBL:
Gene Tree for SULT1E1 (if available)
TreeFam:
Gene Tree for SULT1E1 (if available)

Paralogs for SULT1E1 Gene

(14) SIMAP similar genes for SULT1E1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SULT1E1: view

Variants for SULT1E1 Gene

Sequence variations from dbSNP and Humsavar for SULT1E1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs11569705 - 69,857,581(-) ATAAA(G/T)ATTTT reference, missense
rs1220702 -- 69,847,802(-) TCTCT(C/G)TAATT intron-variant
rs1220703 -- 69,846,443(-) CTAAA(A/T)ATACA intron-variant
rs1220704 -- 69,845,810(-) TGACA(G/T)TGAAT intron-variant
rs1220715 -- 69,850,909(+) TACAT(G/T)CTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULT1E1 Gene

Variant ID Type Subtype PubMed ID
dgv5627n71 CNV Loss 21882294

Variation tolerance for SULT1E1 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULT1E1 Gene

HapMap Linkage Disequilibrium report
SULT1E1
Human Gene Mutation Database (HGMD)
SULT1E1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1E1 Gene

Disorders for SULT1E1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for SULT1E1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anteroseptal myocardial infarction
inferior myocardial infarction
  • inferior myocardial infarction nos
primary amebic meningoencephalitis
  • naegleria fowleri infection
scarlet fever
  • scarlatina
suppurative cholangitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SULT1E1

Genetic Association Database (GAD)
SULT1E1
Human Genome Epidemiology (HuGE) Navigator
SULT1E1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SULT1E1
genes like me logo Genes that share disorders with SULT1E1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT1E1 Gene

Publications for SULT1E1 Gene

  1. Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization. (PMID: 8530066) Her C. … Weinshilboum R.M. (Genomics 1995) 3 4 23 67
  2. Inhibition of human liver steroid sulfotransferase activities by drugs: a novel mechanism of drug toxicity? (PMID: 1397064) Bamforth K.J. … Coughtrie M.W. (Eur. J. Pharmacol. 1992) 23 25 26
  3. Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico--implications for differences in activity, subunit dimerization and substrate inhibition. (PMID: 20025931) Stjernschantz E. … Oostenbrink C. (Mol. Cell. Endocrinol. 2010) 3 23
  4. Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States. (PMID: 20142249) Yong M. … Lampe J.W. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 23
  5. Increased SULT1E1 activity in HepG2 hepatocytes decreases growth hormone stimulation of STAT5b phosphorylation. (PMID: 18831980) Li L. … Falany C.N. (Steroids 2009) 3 23

Products for SULT1E1 Gene

Sources for SULT1E1 Gene

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