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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SULT1E1 Gene

protein-coding GIFtS: 67
GCID: GC04M070676

sulfotransferase family 1E, estrogen-preferring, member...

(Previous names: sulfotransferase, estrogen-preferring )
(Previous symbol: STE)

Explore 32 diseases affiliated with
SULT1E1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sulfotransferase Family 1E, Estrogen-Preferring, Member 1¹ ²		ST1E1² ³
STE¹ ² ³ ⁵		EC 2.8.2.4³ ⁸
Sulfotransferase, Estrogen-Preferring¹ ² ³		Estrogen Sulfotransferase²
EST¹ ² ⁵		Estrone Sulfotransferase²
Sulfotransferase 1E1² ³		EC 2.8.2⁸
EST-1² ³

External Ids:	HGNC: 11377¹	Entrez Gene: 6783²	Ensembl: ENSG00000109193⁷	OMIM: 600043⁵	UniProtKB: P49888³

Export aliases for SULT1E1 gene to outside databases

Previous GC identifers: GC04M071022 GC04M070887 GC04M070741 GC04M066504

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SULT1E1:

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic

compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene

structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a

sulfo moiety to and from estrone, which may control levels of estrogen receptors. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ST1E1_HUMAN, P49888

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the

sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by

metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates

dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at

significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated

Gene Wiki entry for SULT1E1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_022778.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SULT1E1 gene promoter:
TBP RFX1 FOXD1 E4BP4 S8 FOXJ2 (long isoform) FOXJ2 ATF Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SULT1E1 promoter sequence

Search SABiosciences Chromatin IP Primers for SULT1E1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULT1E1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.1 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13.1

SULT1E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT1E1 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M070676: view genomic region (about GC identifiers)

Start:	70,676,498 bp from pter	End:	70,725,870 bp from pter
Size:	49,373 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ST1E1_HUMAN, P49888 (See protein sequence)

Recommended Name: Estrogen sulfotransferase

Size: 294 amino acids; 35126 Da

Subunit: Homodimer

Subcellular location: Cytoplasm

2 PDB 3D structures from and Proteopedia for SULT1E1:

1G3M (3D)

1HY3 (3D)

Secondary accessions: Q8N6X5

Explore the universe of human proteins at neXtProt for SULT1E1: NX_P49888

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49888

4/9 DME Specific Peptides for SULT1E1 (P49888) (see all 9)

ELVDRII

SPFMRKG

FQARPDD

PKSGTTW

SULT1E1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005411.1

ENSEMBL proteins:

ENSP00000420891 ENSP00000226444

Reactome Protein details: P49888
Human Recombinant Protein Products:

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	Uscn Proteins for SULT1E1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0031965	nuclear membrane	IDA	--

SULT1E1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SULT1E1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SULT1E1 for domains About GeneDecksing

1 InterPro domain/family:

IPR000863 Sulfotransferase_dom

Graphical View of Domain Structure for InterPro Entry P49888

ProtoNet protein and cluster: P49888

1 Blocks protein family: IPB000863 Sulfotransferase

UniProtKB/Swiss-Prot: ST1E1_HUMAN, P49888

Similarity: Belongs to the sulfotransferase 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ST1E1_HUMAN, P49888

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the

sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by

metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates

dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at

significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated

Catalytic activity: 3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate

Enzyme Numbers (IUBMB): EC 2.8.2.4¹ ² EC 2.8.2²

miRNA Products:		OriGene 3'-UTR Clone: SULT1E1 Browse MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1E1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004304	estrone sulfotransferase activity	IEA	--
GO:0005496	steroid binding	IEA	--
GO:0047894	flavonol 3-sulfotransferase activity	IDA	--
GO:0050294	steroid sulfotransferase activity	TAS	--

SULT1E1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Sult1e1^tm1Song for SULT1E1
     4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sult1e1):

endocrine/exocrine gland

hematopoietic system

homeostasis/metabolism

reproductive system

SULT1E1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Estrone metabolism

	Estrone metabolism	1.00			Androstenedione and testosterone biosynthesis and metabolism p.1	0.57
	Estrone metabolism	1.00			Androstenedione and testosterone biosynthesis and metabolism p.1	0.57

Tamoxifen metabolism

	Tamoxifen metabolism	1.00			Estradiol metabolism	0.52
	Tamoxifen Pathway, Pharmacokinetics	0.68			Estradiol metabolism	0.52

Cytosolic sulfonation of small molecules

	Cytosolic sulfonation of small molecules	1.00			Sulfur metabolism	0.44
	Sulfation Biotransformation Reaction	0.67

Biological oxidations

	Biological oxidations	1.00			metapathway biotransformation	0.41
	Phase II conjugation	0.52

Acetaminophen Pathway, Pharmacokinetics

Pathway_PA165986194 -need delete

1.00

Acetaminophen Pathway, Pharmacokinetics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for SULT1E1

	Androstenedione and testosterone biosynthesis and metabolism p.1
	Estradiol metabolism
	Estrone metabolism

3 GeneGo (Thomson Reuters) Pathways for SULT1E1

	Estradiol metabolism
	Estrone metabolism
	Androstenedione and testosterone biosynthesis and metabolism p.1

4 BioSystems Pathways for SULT1E1

	Sulfation Biotransformation Reaction
	Tamoxifen metabolism
	Estrogen metabolism
	metapathway biotransformation

4 Reactome Pathways for SULT1E1

	Metabolism
	Biological oxidations
	Cytosolic sulfonation of small molecules
	Phase II conjugation

5 PharmGKB Pathways for SULT1E1

	Acetaminophen Pathway, Pharmacokinetics
	Aromatase Inhibitor Pathway (Multiple Tissues), Pharmacodynamics
	Estrogen Metabolism Pathway
	Pathway_PA165986194 -need delete
	Tamoxifen Pathway, Pharmacokinetics

2 Kegg Pathways (Kegg details for SULT1E1):

	Steroid hormone biosynthesis
	Sulfur metabolism

SULT1E1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SULT1E1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/50 Interacting proteins for SULT1E1 (P49888^{2, 3} ENSP00000226444⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 50)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C14orf1	Q9UKR5²^,³	MINT-63808 I2D: score=5
COPS6	Q7L5N1²^,³	MINT-63804 I2D: score=5
SETDB1	Q15047²^,³	MINT-63802 I2D: score=5
TP53	P04637²^,³	MINT-63800 I2D: score=5
UNC119	Q13432²^,³	MINT-63801 I2D: score=5

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0007565	female pregnancy	IEA	--
GO:0008202	steroid metabolic process	TAS	8185618
GO:0008210	estrogen metabolic process	IDA	11884392
GO:0044281	small molecule metabolic process	TAS	--

SULT1E1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SULT1E1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SULT1E1

7 HMDB Compounds for SULT1E1 About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Hydroxyestrone sulfate	catecholestrogen sulfate;2,3-dihydroxyestra-1,3,5(10)-trien-17one 3-sulfate;1,3,5(10)-triene-2,3-diol-17one 3-sulfate;2HEn-3S	1240-04-6	--
4-Hydroxyestrone sulfate	1,3,5(10)-triene-3,4-diol-17one 3-sulfate;3,4-dihydroxyestra-1,3,5(10)-trien-17one 3-sulfate;4HEn-3S	--	--
Adenosine 3',5'-diphosphate	3,5-Diphosphoadenosine (see all 10)	1053-73-2	--
Estrone	(+)-Estrone (see all 7)	53-16-7	--
Estrone sulfate	Conestoral (see all 12)	481-97-0	--
Phosphoadenosine phosphosulfate	3'-Phospho-5'-adenylyl sulfate (see all 9)	482-67-7	--
Testosterone	(+)-testosterone (see all 86)	58-22-0	--

4 DrugBank Compounds for SULT1E1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
3,5,3',5'-Tetrachloro-Biphenyl-4,4'-Diol	--	--	target	--	17139284 17016423 10592235
Adenosine-3'-5'-Diphosphate	--	--	target	--	17139284 17016423 10592235
3'-Phosphate-Adenosine-5'-Phosphate Sulfate	--	--	target	--	17139284 17016423
Cyclizine	Ciclizina [INN-Spanish] (see all 4)	82-92-8	target	inhibitor	1397064

10/36 Novoseek chemical compound relationships for SULT1E1 gene (see all 36) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
1-hydroxyethylpyrene	89.6	2	9636676 (1), 9566749 (1)
3-phosphoadenosine 5'-phosphosulfate	89.2	19	11884392 (2), 9495883 (1), 10659700 (1), 9348232 (1) (see all 9)
17beta-hydroxysteroid	87.2	27	14979917 (3), 17933521 (1), 19075592 (1), 12459709 (1) (see all 15)
3'-phosphoadenosine 5'-phosphate	86.5	1	10854859 (1)
hydroxysteroid	86.1	6	8033246 (1), 9636676 (1), 11172807 (1), 9068609 (1)
2,6-dichloro-4-nitrophenol	86	6	8185618 (1), 9667746 (1), 1582375 (1)
estrone	85.5	34	8943792 (2), 2212823 (2), 9855023 (2), 19131519 (1) (see all 19)
estrogen	84.5	470	9655902 (7), 15355916 (7), 10659700 (5), 7750469 (5) (see all 99)
estrone sulfate	84.2	12	8943792 (1), 16755106 (1), 2212823 (1), 18663016 (1) (see all 7)
nomegestrol acetate	83.6	2	14981909 (2)

Search CenterWatch for drugs/clinical trials and news about SULT1E1 / ST1E1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SULT1E1 gene:

NM_005420.2

Unigene Cluster for SULT1E1:

Sulfotransferase family 1E, estrogen-preferring, member 1

Hs.479898 [show with all ESTs]

Unigene Representative Sequence: BC027956

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000506796 ENST00000226444(uc003heo.3) ENST00000504002(uc010ihv.1)

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Additional cDNA sequence:

AK310845.1 AK312236.1 BC027956.1 CR407621.1 S77383.1 U08098.1 U55764.1 Y11195.1

4 DOTS entries:

DT.85105493 DT.97815868 DT.100668703 DT.91757474

24/66 AceView cDNA sequences (see all 66):

BX104997 NM_005420 AI375444 AA334154 AL700104 U55764 U08098 BX495003

AI376700 CR407621 CB243762 BU682336 AA993037 W38462 AI340082 T82255

H60426 AI273634 Y11195 H50684 S77383 BX481535 BM745104 AW950477

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SULT1E1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10
SP1:
SP2:																			-
SP3:															-

ECgene alternative splicing isoforms for SULT1E1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SULT1E1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

SULT1E1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Testis

Thoracic Perivascular Adipose

Adipose

Visceral White Adipose

Adipose

Head Mesenchyme

Frontonasal Process

Head Mesenchyme

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SULT1E1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SULT1E1

SOURCE GeneReport for Unigene cluster: Hs.479898

UniProtKB/Swiss-Prot: ST1E1_HUMAN, P49888

Tissue specificity: Liver, intestine and at lower level in the kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including SULT1E1:

Cancer Drug Resistance in human mouse rat

Drug Metabolism: Phase II Enzymes in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1E1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SULT1E1 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SULT1E1⁶	Uncharacterized protein	59(a)	1 ↔ 1	4(53312776-53314417)
zebrafish (Danio rerio)	Actinopterygii	sult1st2⁶ sult1st1⁶ (see all 6)	sulfotransferase family 1, cytosolic sulfotransfer... sulfotransferase family 1, cytosolic sulfotransfer... (see all 6)	46(a) 45(a) (see all 6)	many ↔ many many ↔ many (see all 6)	8(48667606-48678955) 8(48652961-48663057)
fruit fly (Drosophila melanogaster)	Insecta	CG16733¹	CG16733	44.61(n) 30.8(a)		41098 NM_141613.1 NP_649870.1
thale cress (Arabidopsis thaliana)	eudicotyledons	SOT12¹	flavonol sulfotransferase-like protein	48.24(n) 34.15(a)		814903 NM_126423.3 NP_178471.1
rice (Oryza sativa)	Liliopsida	Os12g0270900¹	hypothetical protein	46.83(n) 36.59(a)		4351955 NM_001073082.1 NP_001066550.1

ENSEMBL Gene Tree for SULT1E1 (if available)
TreeFam Gene Tree for SULT1E1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SULT1E1 gene

SULT1C3² SULT4A1² SULT1B1² SULT1C4² SULT1A2² SULT1C2² SULT2B1² SULT1A4²

SULT2A1² SULT6B1² SULT1A1² SULT1A3²

14 SIMAP similar genes for SULT1E1 using alignment to 3 protein entries: ST1E1_HUMAN (see all proteins):

STP1 SULT1A4 SULT1B1 ST1A5 SULT1C3 SULT1A1

SULT1A3 SULT1C2 SULT1A2 SULT1C4 SULT2B1 SULT2A1

SULT6B1 SULT4A1

SULT1E1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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Human Gene Mutation Database (HGMD): SULT1E1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SULT1E1

DNA2.0 Custom Variant and Variant Library Synthesis for SULT1E1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SULT1E1 for disorders           About GeneDecksing

OMIM gene information: 600043    OMIM disorders: --

20/32 diseases for SULT1E1 (see all 32):    About MalaCards

testicular germ cell tumor germ cell tumor birth defects endometrial stromal sarcoma

hearing loss endometrial carcinoma cholelithiasis endometrial cancer

cystic fibrosis endometrial adenocarcinoma epididymitis thymoma

sarcoma breast carcinoma breast disease carcinoma

breast cancer leiomyoma thrombosis liver cancer

1 disease from the University of Copenhagen DISEASES database for SULT1E1:

Breast cancer

10/11 Novoseek disease relationships for SULT1E1 gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	57	45	14642074 (3), 15522178 (3), 17661084 (2), 1580921 (2) (see all 21)
breast carcinoma	49.8	27	12782580 (7), 14623543 (4), 19250194 (2), 9655902 (1) (see all 8)
endometrial cancer	46.9	14	18318428 (3), 19250196 (2), 17197118 (1), 19022235 (1)
endometrial carcinoma	36.1	8	15355916 (4), 8625916 (1), 14556660 (1), 16857224 (1)
carcinoma ductal	34.1	1	12782580 (1)
breast diseases	33.6	1	19308726 (1)
carcinoma	21.3	13	19250194 (2), 12782580 (2), 15355916 (1), 14623543 (1) (see all 5)
tumors	7.62	16	16166425 (2), 17197118 (2), 19159687 (1), 19250194 (1) (see all 9)
cancer	4.05	7	1391981 (2), 19250196 (1), 16303840 (1), 16541422 (1)
adenocarcinoma	0	3	8187949 (1), 16857224 (1)

Genetic Association Database (GAD): SULT1E1
Human Genome Epidemiology (HuGE) Navigator: SULT1E1 (17 documents)

Export disorders for SULT1E1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SULT1E1 gene, integrated from 9 sources (see all 190):
(articles sorted by number of sources associating them with SULT1E1)

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Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization. (PubMed id 8530066)^{1, 2, 9} Her C....Weinshilboum R.M. (1995)
Human liver estrogen sulfotransferase: identification by cDNA cloning and expression. (PubMed id 8185618)^{1, 2, 9} Aksoy I.A.... Weinshilboum R.M. (1994)
Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase. (PubMed id 12782487)^{1, 2, 9} Shevtsov S.... Negishi M. (2003)
Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. (PubMed id 11884392)^{1, 2, 9} Pedersen L.C.... Negishi M. (2002)
Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase. (PubMed id 7779757)^{1, 2, 9} Falany C.N.... Falany J.L. (1995)
Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer. (PubMed id 15894657)^{1, 4} Choi J.Y....Kang D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy. (PubMed id 10541560)^{1, 2} Rubin G.L.... Coughtrie M.W.H. (1999)
Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene. (PubMed id 7961757)^{1, 3} Bernier F.... Luu-The V. (1994)
Regulation of hepatic sulfotransferase (SULT) 1E1 expression and effects on estrogenic activity in cystic fibrosis (CF). (PubMed id 19429440)^{1, 9} Falany C.N....Runge-Morris M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6783	HGNC: 11377	AceView: SULT1E1	Ensembl:ENSG00000109193	euGenes: HUgn6783
ECgene: SULT1E1	Kegg: 6783	H-InvDB: SULT1E1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SULT1E1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SULT1E1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ste/

Intellectual Property for SULT1E1 gene
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Patent Information for SULT1E1 gene:
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