Aliases for SULT1E1 Gene
External Ids for SULT1E1 Gene
Previous HGNC Symbols for SULT1E1 Gene
Previous GeneCards Identifiers for SULT1E1 Gene
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]
GeneCards Summary for SULT1E1 Gene
SULT1E1 (Sulfotransferase Family 1E, Estrogen-Preferring, Member 1) is a Protein Coding gene. Diseases associated with SULT1E1 include endometrial adenocarcinoma and endometrial stromal sarcoma. Among its related pathways are Metabolism and Estrogen metabolism. GO annotations related to this gene include steroid binding and steroid sulfotransferase activity. An important paralog of this gene is SULT1B1.
UniProtKB/Swiss-Prot for SULT1E1 Gene
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.