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Aliases for SULT1C4 Gene

Aliases for SULT1C4 Gene

  • Sulfotransferase Family 1C Member 4 2 3 5
  • Sulfotransferase Family, Cytosolic, 1C, Member 2 2 3
  • Sulfotransferase Family, Cytosolic, 1C, Member 4 2 3
  • Sulfotransferase 1C2 3 4
  • SULT1C#2 3 4
  • SULT1C2 3 4
  • ST1C4 3 4
  • Sulfotransferase Family, Cytosolic, 1C, Member C2 3
  • Sulfotransferase 1C4 3
  • EC 2.8.2.1 61
  • EC 2.8.2.- 4
  • EC 2.8.2 61
  • SULT1C 3

External Ids for SULT1C4 Gene

Previous HGNC Symbols for SULT1C4 Gene

  • SULT1C2

Previous GeneCards Identifiers for SULT1C4 Gene

  • GC02P108360
  • GC02P108994
  • GC02P102593

Summaries for SULT1C4 Gene

Entrez Gene Summary for SULT1C4 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1C4 Gene

SULT1C4 (Sulfotransferase Family 1C Member 4) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1C2.

UniProtKB/Swiss-Prot for SULT1C4 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).

Gene Wiki entry for SULT1C4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1C4 Gene

Genomics for SULT1C4 Gene

Regulatory Elements for SULT1C4 Gene

Enhancers for SULT1C4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F108448 0.4 ENCODE 17.5 +71.6 71583 2.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 GCC2 SULT1C4 PIR33238
GH02F108376 0.2 ENCODE 13.7 +0.2 176 2.8 PKNOX1 ATF1 FEZF1 RAD21 YY1 CREM ZNF843 NR2F2 ZNF610 ZNF585B SULT1C4 SMIM12P1
GH02F108367 0.5 ENCODE 10.7 -10.1 -10078 1.4 JUN FOS RARA SULT1C4 LINC01594 GCC2 GMCL1P2
GH02F108362 0.6 Ensembl ENCODE 10.6 -14.6 -14611 1.8 BCOR JUN ZNF384 ZIC2 ZNF316 NFE2 FOS PRDM10 MAFK NFE2L2 GCC2 SULT1C4 GC02M108364 PIR58189 GC02M108346
GH02F108382 0.5 ENCODE 7.4 +5.1 5124 1.7 CTCF PKNOX1 HLF CEBPB REST ZNF121 JUND SCRT2 IKZF1 GCC2 SULT1C4 SMIM12P1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SULT1C4 on UCSC Golden Path with GeneCards custom track

Promoters for SULT1C4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000596064 689 2000 PKNOX1 ATF1 FEZF1 CREM ZNF843 ZNF610 KLF16 ZNF585B GLIS1 IKZF1

Genomic Location for SULT1C4 Gene

Chromosome:
2
Start:
108,377,911 bp from pter
End:
108,388,989 bp from pter
Size:
11,079 bases
Orientation:
Plus strand

Genomic View for SULT1C4 Gene

Genes around SULT1C4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1C4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1C4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1C4 Gene

Proteins for SULT1C4 Gene

  • Protein details for SULT1C4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75897-ST1C4_HUMAN
    Recommended name:
    Sulfotransferase 1C4
    Protein Accession:
    O75897
    Secondary Accessions:
    • Q069I8
    • Q08AS5
    • Q53S63

    Protein attributes for SULT1C4 Gene

    Size:
    302 amino acids
    Molecular mass:
    35520 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT1C4 Gene

    Alternative splice isoforms for SULT1C4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT1C4 Gene

Selected DME Specific Peptides for SULT1C4 Gene

O75897:
  • FTVAQNE
  • SPFMRKG
  • LYLFYED

Post-translational modifications for SULT1C4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT1C4 Gene

Domains & Families for SULT1C4 Gene

Gene Families for SULT1C4 Gene

Protein Domains for SULT1C4 Gene

Graphical View of Domain Structure for InterPro Entry

O75897

UniProtKB/Swiss-Prot:

ST1C4_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1C4: view

Function for SULT1C4 Gene

Molecular function for SULT1C4 Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).

Enzyme Numbers (IUBMB) for SULT1C4 Gene

Gene Ontology (GO) - Molecular Function for SULT1C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity TAS --
GO:0008146 sulfotransferase activity IEA,TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SULT1C4: view
genes like me logo Genes that share phenotypes with SULT1C4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SULT1C4 Gene

Localization for SULT1C4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1C4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT1C4 Gene COMPARTMENTS Subcellular localization image for SULT1C4 gene
Compartment Confidence
cytosol 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for SULT1C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT1C4: view

Pathways & Interactions for SULT1C4 Gene

genes like me logo Genes that share pathways with SULT1C4: view

Pathways by source for SULT1C4 Gene

Interacting Proteins for SULT1C4 Gene

Selected Interacting proteins: O75897-ST1C4_HUMAN for SULT1C4 Gene via IID

Gene Ontology (GO) - Biological Process for SULT1C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
GO:0051923 sulfation IDA 20056724
genes like me logo Genes that share ontologies with SULT1C4: view

No data available for SIGNOR curated interactions for SULT1C4 Gene

Drugs & Compounds for SULT1C4 Gene

(2) Drugs for SULT1C4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1918
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 1105
genes like me logo Genes that share compounds with SULT1C4: view

Transcripts for SULT1C4 Gene

mRNA/cDNA for SULT1C4 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT1C4 Gene

Sulfotransferase family, cytosolic, 1C, member 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1C4 Gene

No ASD Table

Relevant External Links for SULT1C4 Gene

GeneLoc Exon Structure for
SULT1C4
ECgene alternative splicing isoforms for
SULT1C4

Expression for SULT1C4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SULT1C4 Gene

Protein differential expression in normal tissues from HIPED for SULT1C4 Gene

This gene is overexpressed in Heart (62.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SULT1C4 Gene



Protein tissue co-expression partners for SULT1C4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SULT1C4 Gene:

SULT1C4

SOURCE GeneReport for Unigene cluster for SULT1C4 Gene:

Hs.312644

mRNA Expression by UniProt/SwissProt for SULT1C4 Gene:

O75897-ST1C4_HUMAN
Tissue specificity: Expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord.
genes like me logo Genes that share expression patterns with SULT1C4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SULT1C4 Gene

Orthologs for SULT1C4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1C4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT1C4 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia SULT1C4 34 35
  • 87.31 (n)
cow
(Bos Taurus)
Mammalia SULT1C4 34
  • 82.27 (n)
-- 35
  • 79 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 75 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 57 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sult1c4 34
  • 59.95 (n)
zebrafish
(Danio rerio)
Actinopterygii sult1st5 34 35
  • 58.3 (n)
sult1st1 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001425 34
  • 46.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta St4 34
  • 45.09 (n)
St2 35
  • 29 (a)
OneToMany
Species where no ortholog for SULT1C4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT1C4 Gene

ENSEMBL:
Gene Tree for SULT1C4 (if available)
TreeFam:
Gene Tree for SULT1C4 (if available)

Paralogs for SULT1C4 Gene

(14) SIMAP similar genes for SULT1C4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SULT1C4: view

Variants for SULT1C4 Gene

Sequence variations from dbSNP and Humsavar for SULT1C4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10199772 -- 108,379,964(+) TTCCC(A/C)TAAAA intron-variant
rs111292394 -- 108,384,293(+) GGCGC(A/G)ATCTC intron-variant
rs112168218 -- 108,384,066(+) GTTTC(A/G)CCATG intron-variant
rs112368184 -- 108,384,058(+) GAAAC(A/C)GGGTT intron-variant
rs112375818 -- 108,383,855(+) TTGGG(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULT1C4 Gene

Variant ID Type Subtype PubMed ID
dgv153e55 CNV gain 17911159
dgv4035n100 CNV gain 25217958
dgv4036n100 CNV gain 25217958
dgv724e199 CNV deletion 23128226
esv2236049 CNV deletion 18987734
esv2720498 CNV deletion 23290073
esv2759081 CNV gain 17122850
esv3559919 CNV deletion 23714750
esv3591913 CNV gain 21293372
esv3591924 CNV gain 21293372
nsv469774 CNV gain 16826518
nsv527491 CNV loss 19592680
nsv527686 CNV gain 19592680
nsv834327 CNV gain 17160897

Variation tolerance for SULT1C4 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.34; 81.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULT1C4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT1C4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1C4 Gene

Disorders for SULT1C4 Gene

Relevant External Links for SULT1C4

Human Genome Epidemiology (HuGE) Navigator
SULT1C4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SULT1C4

No disorders were found for SULT1C4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SULT1C4 Gene

Publications for SULT1C4 Gene

  1. Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization. (PMID: 10783263) Freimuth R.R. … Weinshilboum R.M. (Genomics 2000) 2 3 4 22 64
  2. Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2- acetylaminofluorene. (PMID: 9852044) Sakakibara Y. … Liu M.-C. (J. Biol. Chem. 1998) 2 3 4 64
  3. Structural and chemical profiling of the human cytosolic sulfotransferases. (PMID: 17425406) Allali-Hassani A. … Arrowsmith C.H. (PLoS Biol. 2007) 3 4 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. Human cytosolic sulfotransferase SULT1C4 mediates the sulfation of doxorubicin and epirubicin. (PMID: 26948952) Luo L. … Liu M.C. (Drug Metab. Pharmacokinet. 2016) 3 64

Products for SULT1C4 Gene

Sources for SULT1C4 Gene

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