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Aliases for SULT1C4 Gene

Aliases for SULT1C4 Gene

  • Sulfotransferase Family 1C Member 4 2 3 5
  • Sulfotransferase Family, Cytosolic, 1C, Member 2 2 3
  • Sulfotransferase Family, Cytosolic, 1C, Member 4 2 3
  • Sulfotransferase 1C2 3 4
  • SULT1C#2 3 4
  • SULT1C2 3 4
  • ST1C4 3 4
  • Sulfotransferase Family, Cytosolic, 1C, Member C2 3
  • EC 2.8.2.1 63
  • EC 2.8.2.- 4
  • EC 2.8.2 63
  • SULT1C 3

External Ids for SULT1C4 Gene

Previous HGNC Symbols for SULT1C4 Gene

  • SULT1C2

Previous GeneCards Identifiers for SULT1C4 Gene

  • GC02P108360
  • GC02P108994
  • GC02P102593

Summaries for SULT1C4 Gene

Entrez Gene Summary for SULT1C4 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1C4 Gene

SULT1C4 (Sulfotransferase Family 1C Member 4) is a Protein Coding gene. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT1C4 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).

Gene Wiki entry for SULT1C4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1C4 Gene

Genomics for SULT1C4 Gene

Regulatory Elements for SULT1C4 Gene

Promoters for SULT1C4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SULT1C4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SULT1C4 gene promoter:

Genomic Location for SULT1C4 Gene

Chromosome:
2
Start:
108,377,911 bp from pter
End:
108,388,989 bp from pter
Size:
11,079 bases
Orientation:
Plus strand

Genomic View for SULT1C4 Gene

Genes around SULT1C4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1C4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1C4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1C4 Gene

Proteins for SULT1C4 Gene

  • Protein details for SULT1C4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75897-ST1C4_HUMAN
    Recommended name:
    Sulfotransferase 1C4
    Protein Accession:
    O75897
    Secondary Accessions:
    • Q069I8
    • Q08AS5
    • Q53S63

    Protein attributes for SULT1C4 Gene

    Size:
    302 amino acids
    Molecular mass:
    35520 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT1C4 Gene

    Alternative splice isoforms for SULT1C4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT1C4 Gene

Proteomics data for SULT1C4 Gene at MOPED

Selected DME Specific Peptides for SULT1C4 Gene

Post-translational modifications for SULT1C4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT1C4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SULT1C4

Domains & Families for SULT1C4 Gene

Gene Families for SULT1C4 Gene

Protein Domains for SULT1C4 Gene

Graphical View of Domain Structure for InterPro Entry

O75897

UniProtKB/Swiss-Prot:

ST1C4_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1C4: view

Function for SULT1C4 Gene

Molecular function for SULT1C4 Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).

Enzyme Numbers (IUBMB) for SULT1C4 Gene

genes like me logo Genes that share phenotypes with SULT1C4: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SULT1C4 Gene

Localization for SULT1C4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1C4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT1C4 Gene COMPARTMENTS Subcellular localization image for SULT1C4 gene
Compartment Confidence
cytosol 5
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SULT1C4 Gene

Pathways & Interactions for SULT1C4 Gene

genes like me logo Genes that share pathways with SULT1C4: view

Pathways by source for SULT1C4 Gene

Interacting Proteins for SULT1C4 Gene

Selected Interacting proteins: O75897-ST1C4_HUMAN for SULT1C4 Gene via I2D

Symbol External ID(s) Details
GABPA

Gene Ontology (GO) - Biological Process for SULT1C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
genes like me logo Genes that share ontologies with SULT1C4: view

No data available for SIGNOR curated interactions for SULT1C4 Gene

Drugs & Compounds for SULT1C4 Gene

(2) Drugs for SULT1C4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1844
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 808
genes like me logo Genes that share compounds with SULT1C4: view

Transcripts for SULT1C4 Gene

mRNA/cDNA for SULT1C4 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT1C4 Gene

Sulfotransferase family, cytosolic, 1C, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1C4 Gene

No ASD Table

Relevant External Links for SULT1C4 Gene

GeneLoc Exon Structure for
SULT1C4
ECgene alternative splicing isoforms for
SULT1C4

Expression for SULT1C4 Gene

mRNA expression in normal human tissues for SULT1C4 Gene

Protein differential expression in normal tissues from HIPED for SULT1C4 Gene

This gene is overexpressed in Heart (62.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SULT1C4 Gene



SOURCE GeneReport for Unigene cluster for SULT1C4 Gene Hs.312644

mRNA Expression by UniProt/SwissProt for SULT1C4 Gene

O75897-ST1C4_HUMAN
Tissue specificity: Expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord.
genes like me logo Genes that share expression patterns with SULT1C4: view

Protein tissue co-expression partners for SULT1C4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SULT1C4 Gene

Orthologs for SULT1C4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1C4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SULT1C4 35
  • 82.27 (n)
  • 79.12 (a)
-- 36
  • 77 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SULT1C4 35
  • 87.31 (n)
  • 82.78 (a)
SULT1C4 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SULT1C4 35
  • 99.45 (n)
  • 99.67 (a)
SULT1C4 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sult1c4 35
  • 59.95 (n)
  • 55.4 (a)
zebrafish
(Danio rerio)
Actinopterygii sult1st1 35
sult1st5 35
  • 58.3 (n)
  • 50.53 (a)
sult1st5 36
  • 49 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001425 35
  • 46.82 (n)
  • 37.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta St4 35
  • 45.09 (n)
  • 34.5 (a)
St2 36
  • 29 (a)
OneToMany
Species with no ortholog for SULT1C4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT1C4 Gene

ENSEMBL:
Gene Tree for SULT1C4 (if available)
TreeFam:
Gene Tree for SULT1C4 (if available)

Paralogs for SULT1C4 Gene

(14) SIMAP similar genes for SULT1C4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SULT1C4: view

Variants for SULT1C4 Gene

Sequence variations from dbSNP and Humsavar for SULT1C4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1402467 - 108,378,352(+) CACGA(C/G)ATGGA reference, missense
rs41322445 - 108,381,796(+) TTAAT(A/G)CAAAA reference, missense
rs1967571 -- 108,388,050(-) GCCGA(A/G)GCGGG downstream-variant-500B, utr-variant-3-prime
rs1967572 -- 108,387,900(-) GGAAT(A/G)GCGTG downstream-variant-500B, utr-variant-3-prime
rs2293068 -- 108,386,281(-) TCAAA(C/G/T)GAAGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SULT1C4 Gene

Variant ID Type Subtype PubMed ID
esv2720498 CNV Deletion 23290073
dgv1234e1 CNV Complex 17122850
dgv724e199 CNV Deletion 23128226
nsv874770 CNV Loss 21882294
nsv527686 CNV Gain 19592680
dgv153e55 CNV Gain 17911159
nsv527491 CNV Loss 19592680
nsv834327 CNV Gain 17160897
nsv469774 CNV Complex 16826518
nsv874772 CNV Gain 21882294
esv2236049 CNV Deletion 18987734

Variation tolerance for SULT1C4 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.34; 81.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULT1C4 Gene

HapMap Linkage Disequilibrium report
SULT1C4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1C4 Gene

Disorders for SULT1C4 Gene

Relevant External Links for SULT1C4

Human Genome Epidemiology (HuGE) Navigator
SULT1C4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SULT1C4

No disorders were found for SULT1C4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SULT1C4 Gene

Publications for SULT1C4 Gene

  1. Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization. (PMID: 10783263) Freimuth R.R. … Weinshilboum R.M. (Genomics 2000) 2 3 4 23 67
  2. Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2- acetylaminofluorene. (PMID: 9852044) Sakakibara Y. … Liu M.-C. (J. Biol. Chem. 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3

Products for SULT1C4 Gene

Sources for SULT1C4 Gene

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