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SULT1C4 Gene

protein-coding   GIFtS: 53
GCID: GC02P108994

Sulfotransferase Family, Cytosolic, 1C, Member 4

(Previous names: sulfotransferase family, cytosolic, 1C, member 2)
(Previous symbol: SULT1C2)
  Search for SULT1C4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sulfotransferase Family, Cytosolic, 1C, Member 41 2     SULT1C2
SULT1C21 2 3 5     Sulfotransferase 1C42
Sulfotransferase Family, Cytosolic, 1C, Member 21 2     Sulfotransferase Family, Cytosolic, 1C, Member C22
Sulfotransferase 1C22 3     EC 2.8.2.-3
ST1C42 3     EC 2.8.28
SULT1C#22 3     EC 2.8.2.18

External Ids:    HGNC: 114571   Entrez Gene: 272332   Ensembl: ENSG000001980757   OMIM: 6083575   UniProtKB: O758973   

Export aliases for SULT1C4 gene to outside databases

Previous GC identifers: GC02P108360 GC02P102593


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SULT1C4 Gene:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and
xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate
specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes
a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to
phenol-containing compounds. (provided by RefSeq, Jul 2008)

GeneCards Summary for SULT1C4 Gene:
SULT1C4 (sulfotransferase family, cytosolic, 1C, member 4) is a protein-coding gene. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1C3.

UniProtKB/Swiss-Prot: ST1C4_HUMAN, O75897
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the
activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and
N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF)

Gene Wiki entry for SULT1C4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SULT1C4 gene promoter:
         HFH-3   FOXI1   Nkx2-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSULT1C4 promoter sequence
   Search Chromatin IP Primers for SULT1C4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SULT1C4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.3   Ensembl cytogenetic band:  2q12.3   HGNC cytogenetic band: 2q12.3

SULT1C4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT1C4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P108994:  view genomic region     (about GC identifiers)

Start:
108,994,367 bp from pter      End:
109,004,513 bp from pter
Size:
10,147 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ST1C4_HUMAN, O75897 (See protein sequence)
Recommended Name: Sulfotransferase 1C4  
Size: 302 amino acids; 35520 Da
2 PDB 3D structures from and Proteopedia for SULT1C4:
2AD1 (3D)        2GWH (3D)    
Secondary accessions: Q069I8 Q53S63

Explore the universe of human proteins at neXtProt for SULT1C4: NX_O75897

Explore proteomics data for SULT1C4 at MOPED

3 DME Specific Peptides for SULT1C4 (O75897)
 SPFMRKG  LYLFYED  FTVAQNE 


See SULT1C4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006579.2  
ENSEMBL proteins: 
 ENSP00000272452   ENSP00000387225  
Reactome Protein details: O75897

SULT1C4 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SULT: Sulfotransferases, cytosolic

2 InterPro protein domains:
 IPR027417 P-loop_NTPase
 IPR000863 Sulfotransferase_dom

Graphical View of Domain Structure for InterPro Entry O75897

ProtoNet protein and cluster: O75897

1 Blocks protein domain: IPB000863 Sulfotransferase

UniProtKB/Swiss-Prot: ST1C4_HUMAN, O75897
Similarity: Belongs to the sulfotransferase 1 family


Find genes that share domains with SULT1C4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ST1C4_HUMAN, O75897
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the
activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and
N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF)

     Enzyme Numbers (IUBMB): EC 2.8.2.-1 EC 2.8.22 EC 2.8.2.12

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008146sulfotransferase activity NAS9852044
     
Find genes that share ontologies with SULT1C4           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for SULT1C4:
 Decreased influenza A virus in 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ST1C4_HUMAN, O75897: Cytoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005829cytosol TAS--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SULT1C4 About    
See pathways by source

SuperPathContained pathways About
1Biological oxidations
Biological oxidations0.56
metapathway biotransformation0.42
Phase II conjugation0.56
Cytosolic sulfonation of small molecules0.00
2Metabolism
Metabolism0.38
3Sulfation Biotransformation Reaction
Sulfation Biotransformation Reaction


Find genes that share SuperPaths with SULT1C4           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 BioSystems Pathways for SULT1C4
    Sulfation Biotransformation Reaction
metapathway biotransformation

1 Reactome Pathway for SULT1C4
    Cytosolic sulfonation of small molecules


    Pathway & Disease-focused RT2 Profiler PCR Array including SULT1C4: 
          Drug Metabolism: Phase II Enzymes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for SULT1C4

1 Interacting protein for SULT1C4 (O758973) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
GABPAQ065463I2D: score=2 
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006805xenobiotic metabolic process TAS--
GO:0044281small molecule metabolic process TAS--
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process TAS--
GO:0051923sulfation IDA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SULT1C4 (ST1C4)

2 PharmGKB related drug/compound annotations for SULT1C4 gene    About this table
Drug/compound PharmGKB Annotation
docetaxelCA  
thalidomideCA  



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SULT1C4 gene: 
NM_006588.2  

Unigene Cluster for SULT1C4:

Sulfotransferase family, cytosolic, 1C, member 4
Hs.312644  [show with all ESTs]
Unigene Representative Sequence: BC058861
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000494122 ENST00000272452(uc010ywr.1 uc002tea.1 uc002teb.1)
ENST00000409309
miRNA
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  QuantiFast Probe-based Assays in human, mouse, rat SULT1C4

Additional mRNA sequence: 

AK297851.1 AK298755.1 BC058861.1 BC125043.1 

3 DOTS entries:

DT.100652382  DT.40307605  DT.95335092 

17 AceView cDNA sequences:

CR621339 AL602565 NM_006588 CR625884 BX431651 BX417913 BC058861 BX454655 
BX435657 BI765204 AI123687 BG186483 AF055584 BX281811 W38522 R58632 
BX442689 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SULT1C4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SULT1C4 Expression
About this image

SULT1C4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SULT1C4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.312644

UniProtKB/Swiss-Prot: ST1C4_HUMAN, O75897
Tissue specificity: Expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult
kidney, ovary and spinal chord

    Pathway & Disease-focused RT2 Profiler PCR Array including SULT1C4: 
          Drug Metabolism: Phase II Enzymes in human mouse rat

Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1C4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SULT1C4 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia SULT1C41 sulfotransferase family, cytosolic, 1C, member 4 87.31(n)
82.78(a)
  474542  XM_531771.4  XP_531771.1 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 8)
Uncharacterized protein
(see all 8)
57(a)
56(a)
(see all 8)
many ↔ many
many ↔ many
(see all 8)
GL343287.1(906014-911502)
GL343287.1(841283-850888)
tropical clawed frog
(Xenopus tropicalis)
Amphibia sult1c41 sulfotransferase family, cytosolic, 1C, member 4 59.95(n)
55.4(a)
  496982  NM_001011489.1  NP_001011489.1 
zebrafish
(Danio rerio)
Actinopterygii sult1st12 sulfotransferase family, cytosolic sulfotransferase more 71.78(n)   323424  AY181064.1 
fruit fly
(Drosophila melanogaster)
Insecta St41 Sulfotransferase 4 45.09(n)
34.5(a)
  36548  NM_137074.2  NP_610918.1 


ENSEMBL Gene Tree for SULT1C4 (if available)
TreeFam Gene Tree for SULT1C4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SULT1C4 gene
SULT1C32  SULT4A12  SULT1B12  SULT1A22  SULT1C22  SULT1E12  SULT2B12  SULT1A42  
SULT2A12  SULT6B12  SULT1A12  SULT1A32  
14 SIMAP similar genes for SULT1C4 using alignment to 3 protein entries:     ST1C4_HUMAN (see all proteins):
STP1    SULT1B1    SULT1E1    SULT1C3    SULT1C2    SULT1A3
SULT2B1    SULT1A2    SULT2A1    SULT1A4    ST1A5    SULT1A1
SULT6B1    SULT4A1

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SULT1C4 (see all 309)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs38341271,2
C--108992548(-) CCCCC-/TAATAG 1 -- us2k10--------
rs413713521,2
C,F--108992645(+) CTAAAT/CATATT 1 -- us2k15Minor allele frequency- C:0.01NS 188
rs1924296241,2
--108992732(+) TCAAGA/GTCACT 1 -- us2k10--------
rs415131521,2
C,F--108992863(+) CACTGG/CAGAAA 1 -- us2k15Minor allele frequency- C:0.01NS 188
rs1852316911,2
--108992894(+) TATCTA/GCCACT 1 -- us2k10--------
rs1430390951,2
--108992983(+) TGTTTA/GAATGC 1 -- us2k10--------
rs1389909951,2
--108993144(+) TGAACA/GAAGTC 1 -- us2k10--------
rs1422538591,2
--108993186(+) AACATG/TTCCCT 1 -- us2k10--------
rs134028961,2
C--108993221(+) tttatC/Ttcccc 1 -- us2k10--------
rs415145501,2
C,F--108993253(+) TTAAGA/GTCCCC 1 -- us2k16Minor allele frequency- G:0.11NS WA 308

HapMap Linkage Disequilibrium report for SULT1C4 (108994367 - 109004513 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for SULT1C4 (see all 11):    About this table    
Variant IDTypeSubtypePubMed ID
esv2720498CNV Deletion23290073
dgv724e199CNV Deletion23128226
esv2236049CNV Deletion18987734
nsv527491CNV Loss19592680
nsv874770CNV Loss21882294
nsv834327CNV Gain17160897
nsv874772CNV Gain21882294
nsv527686CNV Gain19592680
dgv153e55CNV Gain17911159
nsv469774CNV Complex16826518

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SULT1C4
DNA2.0 Custom Variant and Variant Library Synthesis for SULT1C4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608357    OMIM disorders: --


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Human Genome Epidemiology (HuGE) Navigator: SULT1C4 (1 document)

Export disorders for SULT1C4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SULT1C4 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with SULT1C4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization. (PubMed id 10783263)1, 2, 3, 9 Freimuth R.R.... Weinshilboum R.M. (Genomics 2000)
  2. Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2- acetylaminofluorene. (PubMed id 9852044)1, 2, 3 Sakakibara Y.... Liu M.-C. (J. Biol. Chem. 1998)
  3. Structural and chemical profiling of the human cytosolic sulfotransferases. (PubMed id 17425406)1, 2 Allali-Hassani A.... Arrowsmith C.H. (PLoS Biol. 2007)
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. (PubMed id 11535246)1 Glatt H....Meinl W. (Mutat. Res. 2001)
  7. Sulfotransferases: genetics and role in toxicology. (PubMed id 10720750)1 Glatt H....Meinl W. (Toxicol. Lett. 2000)
  8. Sulfotransferases in the bioactivation of xenobiotics. (PubMed id 11154739)1 Glatt H. (Chem. Biol. Interact. 2000)
  9. Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. (PubMed id 9034160)1 Weinshilboum R.M....Raftogianis R.B. (FASEB J. 1997)
  10. Involvement of ST1B subfamily of cytosolic sulfotransferase in kynurenine metabolism to form natriuretic xanthurenic acid sulfate. (PubMed id 18815351)9 Senggunprai L....Yamazoe Y. (J. Pharmacol. Exp. Ther. 2008)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27233 HGNC: 11457 AceView: SULT1C2 Ensembl:ENSG00000198075 euGenes: HUgn27233
ECgene: SULT1C4 H-InvDB: SULT1C4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SULT1C4 Pharmacogenomics, SNPs, Pathways
NIEHS-SNPshttp://egp.gs.washington.edu/data/sult1c2/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SULT1C4 gene:
Search GeneIP for patents involving SULT1C4

GeneCards and IP:
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