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Aliases for SULT1C3 Gene

Aliases for SULT1C3 Gene

  • Sulfotransferase Family 1C Member 3 2 3 5
  • Sulfotransferase Family, Cytosolic, 1C, Member 3 2 3
  • ST1C3 3 4
  • EC 63
  • EC 4
  • EC 2.8.2 63

External Ids for SULT1C3 Gene

Previous GeneCards Identifiers for SULT1C3 Gene

  • GC02P108323
  • GC02P108863
  • GC02P102462

Summaries for SULT1C3 Gene

GeneCards Summary for SULT1C3 Gene

SULT1C3 (Sulfotransferase Family 1C Member 3) is a Protein Coding gene. Among its related pathways are Sulfation Biotransformation Reaction and Phase II conjugation. GO annotations related to this gene include sulfotransferase activity and alcohol sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT1C3 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.

Gene Wiki entry for SULT1C3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1C3 Gene

Genomics for SULT1C3 Gene

Regulatory Elements for SULT1C3 Gene

Enhancers for SULT1C3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SULT1C3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SULT1C3 gene promoter:

Genomic Location for SULT1C3 Gene

108,239,974 bp from pter
108,265,608 bp from pter
25,635 bases
Plus strand

Genomic View for SULT1C3 Gene

Genes around SULT1C3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1C3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1C3 Gene

Proteins for SULT1C3 Gene

  • Protein details for SULT1C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sulfotransferase 1C3
    Protein Accession:
    Secondary Accessions:
    • Q6IMI5

    Protein attributes for SULT1C3 Gene

    304 amino acids
    Molecular mass:
    35889 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT1C3 Gene

    Alternative splice isoforms for SULT1C3 Gene


neXtProt entry for SULT1C3 Gene

Proteomics data for SULT1C3 Gene at MOPED

Selected DME Specific Peptides for SULT1C3 Gene

Post-translational modifications for SULT1C3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT1C3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SULT1C3 Gene

Gene Families for SULT1C3 Gene

Protein Domains for SULT1C3 Gene

Suggested Antigen Peptide Sequences for SULT1C3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfotransferase 1 family.
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1C3: view

Function for SULT1C3 Gene

Molecular function for SULT1C3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + an alcohol = adenosine 3,5-bisphosphate + an alkyl sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.

Enzyme Numbers (IUBMB) for SULT1C3 Gene

Gene Ontology (GO) - Molecular Function for SULT1C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with SULT1C3: view

Phenotypes for SULT1C3 Gene

MGI mutant phenotypes for SULT1C3:
inferred from 1 alleles
GenomeRNAi human phenotypes for SULT1C3:
genes like me logo Genes that share phenotypes with SULT1C3: view

Animal Models for SULT1C3 Gene

MGI Knock Outs for SULT1C3:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SULT1C3 Gene

Localization for SULT1C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1C3 Gene


Subcellular locations from

Jensen Localization Image for SULT1C3 Gene COMPARTMENTS Subcellular localization image for SULT1C3 gene
Compartment Confidence
cytosol 4
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for SULT1C3 Gene

Pathways & Interactions for SULT1C3 Gene

genes like me logo Genes that share pathways with SULT1C3: view

Pathways by source for SULT1C3 Gene

Interacting Proteins for SULT1C3 Gene

Gene Ontology (GO) - Biological Process for SULT1C3 Gene


No data available for SIGNOR curated interactions for SULT1C3 Gene

Drugs & Compounds for SULT1C3 Gene

(2) Additional Compounds for SULT1C3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
genes like me logo Genes that share compounds with SULT1C3: view

Transcripts for SULT1C3 Gene

mRNA/cDNA for SULT1C3 Gene

(6) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT1C3 Gene

Sulfotransferase family, cytosolic, 1C, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1C3 Gene

No ASD Table

Relevant External Links for SULT1C3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SULT1C3 Gene

mRNA expression in normal human tissues for SULT1C3 Gene

mRNA differential expression in normal tissues according to GTEx for SULT1C3 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x37.5) and Skin - Not Sun Exposed (Suprapubic) (x6.0).

Protein differential expression in normal tissues from HIPED for SULT1C3 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SULT1C3 Gene

SOURCE GeneReport for Unigene cluster for SULT1C3 Gene Hs.535156

mRNA Expression by UniProt/SwissProt for SULT1C3 Gene

Tissue specificity: Isoform 1 is not detectable in any of the tissues tested. Isoform 2 is expresssed in the small intestine.
genes like me logo Genes that share expression patterns with SULT1C3: view

Protein tissue co-expression partners for SULT1C3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SULT1C3 Gene

Orthologs for SULT1C3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1C3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SULT1C3 35
  • 71.02 (n)
  • 67.84 (a)
SULT1C3 36
  • 64 (a)
(Canis familiaris)
Mammalia LOC481309 35
  • 74.88 (n)
  • 67.71 (a)
SULT1C3 36
  • 64 (a)
(Mus musculus)
Mammalia Sult1c1 35
  • 74.32 (n)
  • 69.61 (a)
Sult1c1 16
Sult1c1 36
  • 65 (a)
(Pan troglodytes)
Mammalia LOC100608286 35
  • 89.33 (n)
  • 84.16 (a)
SULT1C3 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Sult1c3 35
  • 74.44 (n)
  • 69.26 (a)
(Monodelphis domestica)
Mammalia SULT1C3 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia SULT1C3 36
  • 58 (a)
(Gallus gallus)
Aves SULT1C3 35
  • 67.26 (n)
  • 62.9 (a)
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493528 35
  • 66.87 (n)
  • 57.93 (a)
(Danio rerio)
Actinopterygii sult1st2 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta St2 36
  • 26 (a)
Species with no ortholog for SULT1C3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT1C3 Gene

Gene Tree for SULT1C3 (if available)
Gene Tree for SULT1C3 (if available)

Paralogs for SULT1C3 Gene

(14) SIMAP similar genes for SULT1C3 Gene using alignment to 1 proteins: Pseudogenes for SULT1C3 Gene

genes like me logo Genes that share paralogs with SULT1C3: view

Variants for SULT1C3 Gene

Sequence variations from dbSNP and Humsavar for SULT1C3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs17035911 - 108,255,615(+) GTCCT(A/G)CTACC reference, missense
rs2219078 - 108,258,742(+) TTGGC(A/G)GGTCC reference, missense
rs6722745 - 108,258,788(+) AGACA(C/T)GCACC reference, missense
rs11903659 - 108,252,454(+) GACAC(A/G)CTTTC reference, missense
rs3083208 -- 108,238,150(+) TTTTT(-/TT)CATAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SULT1C3 Gene

Variant ID Type Subtype PubMed ID
esv2720498 CNV Deletion 23290073
dgv1233e1 CNV Complex 17122850
dgv1234e1 CNV Complex 17122850
dgv724e199 CNV Deletion 23128226
nsv874769 CNV Gain 21882294
nsv874770 CNV Loss 21882294
nsv527686 CNV Gain 19592680
dgv153e55 CNV Gain 17911159
nsv527491 CNV Loss 19592680
nsv874771 CNV Gain 21882294
nsv834327 CNV Gain 17160897

Variation tolerance for SULT1C3 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.44; 95.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULT1C3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1C3 Gene

Disorders for SULT1C3 Gene

Relevant External Links for SULT1C3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SULT1C3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SULT1C3 Gene

Publications for SULT1C3 Gene

  1. Structural and chemical profiling of the human cytosolic sulfotransferases. (PMID: 17425406) Allali-Hassani A. … Arrowsmith C.H. (PLoS Biol. 2007) 2 3 4 67
  2. Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. (PMID: 14676822) Freimuth R.R. … Weinshilboum R.M. (Pharmacogenomics J. 2004) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function. (PMID: 24335392) Duniec-Dmuchowski Z. … Kocarek T.A. (Drug Metab. Dispos. 2014) 3
  5. Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. (PMID: 24954895) Simino J. … Rao D.C. (Am. J. Hum. Genet. 2014) 3

Products for SULT1C3 Gene

Sources for SULT1C3 Gene