SULT1C3 Gene
protein-coding GIFtS: 43
GCID: GC02P108863
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|
sulfotransferase family, cytosolic, 1C, member 3
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Aliases
for SULT1C3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sulfotransferase Family, Cytosolic, 1C, Member 31 2 | | ST1C32 3 | | Sulfotransferase 1C32 | | EC 2.8.2.23 | | EC 2.8.28 | | EC 2.8.2.18 |
Export aliases for SULT1C3 gene to outside databasesPrevious GC identifers: GC02P108323 GC02P108230 GC02P102462 |
Summaries
for SULT1C3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ST1C3_HUMAN, Q6IMI6Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has lowsulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfateconjugation of xenobiotic compounds and endogenous substrates
Gene Wiki entry for SULT1C3
|
Genomic Views
for SULT1C3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SULT1C3 gene promoter:
AREB6
Other transcription factors
Search SABiosciences Chromatin IP Primers for SULT1C3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULT1C3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q12.3 Ensembl cytogenetic band: 2q12.3 HGNC cytogenetic band: 2q12.3SULT1C3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P108863: view genomic region
(about GC identifiers)
Start:
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108,863,651 bp from pter |
End:
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108,881,807 bp from pter |
Size:
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18,157 bases |
Orientation:
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plus strand |
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Proteins
for SULT1C3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ST1C3_HUMAN, Q6IMI6 (See
protein sequence)Recommended Name: Sulfotransferase 1C3 Size: 304 amino acids; 35889 Da
Subcellular location: Cytoplasm (By similarity)
2 PDB 3D structures from  and Proteopedia  for SULT1C3:2H8K (3D)
2REO (3D)
Secondary accessions: Q6IMI5Alternative splicing: 2 isoforms: Q6IMI6-1 Q6IMI6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SULT1C3: NX_Q6IMI6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6IMI6
4/5 DME Specific Peptides for SULT1C3 (Q6IMI6) (see all 5)
SULT1C3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001008743.1
ENSEMBL proteins: ENSP00000333310 ENSP00000365890
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
SULT1C3 for ontologies About GeneDecksing
SULT1C3 Antibody Products:
Assay Products for SULT1C3: |
Protein
Domains /
Families
for SULT1C3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SULT1C3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6IMI6ProtoNet protein and cluster: Q6IMI6 1 Blocks protein family: IPB000863 Sulfotransferase
UniProtKB/Swiss-Prot: ST1C3_HUMAN, Q6IMI6Similarity: Belongs to the sulfotransferase 1 family |
Function
for SULT1C3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ST1C3_HUMAN, Q6IMI6Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has lowsulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfateconjugation of xenobiotic compounds and endogenous substratesCatalytic activity: 3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfateEnzyme Numbers (IUBMB): EC 2.8.22 EC 2.8.2.21 EC 2.8.2.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SULT1C3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SULT1C3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SULT1C3 (NM_001008743) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SULT1C3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULT1C3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1C3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004027 | alcohol sulfotransferase activity |
IDA | 17936463 | | GO:0004062 | aryl sulfotransferase activity |
IEA | -- |
SULT1C3 for ontologies About GeneDecksing
|
Pathways & Interactions
for SULT1C3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytosolic sulfonation of small molecules | | | 2 | Biological oxidations | |
2  BioSystems Pathways for SULT1C3
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SULT1C3
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006790 | sulfur compound metabolic process |
IEA | -- |
SULT1C3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SULT1C3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SULT1C3
Search CenterWatch for drugs/clinical trials and news about SULT1C3 / ST1C3
|
Transcripts
for SULT1C3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SULT1C3 gene: NM_001008743.1 Unigene Cluster for SULT1C3: Sulfotransferase family, cytosolic, 1C, member 3 Hs.535156 Unigene Representative Sequence: NM_0010087432 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000329106(uc010ywo.2) ENST00000376700
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SULT1C3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SULT1C3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SULT1C3 (NM_001008743) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SULT1C3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULT1C3 |
GeneLoc Exon Structure
|
Expression
for SULT1C3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SULT1C3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACCGGATCC
About this image
See SULT1C3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.535156
UniProtKB/Swiss-Prot: ST1C3_HUMAN, Q6IMI6Tissue specificity: Not detectable in any of the tissues tested
SABiosciences Expression via Pathway-Focused PCR Array including SULT1C3: | Drug Metabolism: Phase II Enzymes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SULT1C3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SULT1C3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SULT1C3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SULT1C3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1C3 |
Orthologs
for SULT1C3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SULT1C3 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for SULT1C3 (if available)
TreeFam Gene Tree for SULT1C3 (if available) |
Paralogs
for SULT1C3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SULT1C3 gene
- SULT4A12 SULT1B12 SULT1C42 SULT1A22 SULT1C22 SULT2B12 SULT1E12 SULT1A42
- SULT2A12 SULT6B12 SULT1A12 SULT1A32
14 SIMAP similar genes for SULT1C3 using alignment to 1 protein entry: ST1C3_HUMAN:STP1 SULT1E1 SULT1B1 SULT1C2 SULT1A4 ST1A5
SULT1C4 SULT1A3 SULT1A1 SULT1A2 SULT2A1 SULT2B1
SULT4A1 SULT6B1
SULT1C3 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for SULT1C3
PGOHUM00000237783 PGOHUM00000245584
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Genomic Variants
for SULT1C3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SULT1C3 (108863651 - 108881807 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SULT1C3
3 CNVs: 3382 8382 2403 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SULT1C3 |
|
Disorders
/ Diseases
for SULT1C3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SULT1C3 for disorders About GeneDecksing
2  diseases for SULT1C3: About MalaCardsneuronitis alcoholism
Human Genome Epidemiology (HuGE) Navigator: SULT1C3 (1 document)
Export disorders for SULT1C3 gene to outside databases
|
Publications
for SULT1C3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SULT1C3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SULT1C3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural and chemical profiling of the human cytosolic sulfotransferases. (PubMed id 17425406)1, 2, 3 Allali-Hassani A....Arrowsmith C.H. (2007)
- Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. (PubMed id 14676822)1, 2, 3 Freimuth R.R.... Weinshilboum R.M. (2004)
- SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens. (PubMed id 17936463)1, 2 Meinl W.... Glatt H. (2008)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
|
External Searches for SULT1C3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SULT1C3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SULT1C3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SULT1C3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SULT1C3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SULT1C3 gene:
Search GeneIP for patents involving SULT1C3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SULT1C3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SULT1C3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SULT1C3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SULT1C3 | | | OriGene Protein Over-expression Lysate for SULT1C3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SULT1C3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SULT1C3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SULT1C3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | SULT1C3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1C3 |
|  |  |  | | | | ThermoFisher Antibodies for SULT1C3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULT1C3 |
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