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SULT1C3 Gene

protein-coding   GIFtS: 43
GCID: GC02P108863

Sulfotransferase Family, Cytosolic, 1C, Member 3

  Search for SULT1C3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sulfotransferase Family, Cytosolic, 1C, Member 31 2
ST1C32 3
Sulfotransferase 1C32
EC 2.8.2.23
EC 2.8.28
EC 2.8.2.18

External Ids:    HGNC: 335431   Entrez Gene: 4420382   Ensembl: ENSG000001962287   UniProtKB: Q6IMI63   

Export aliases for SULT1C3 gene to outside databases

Previous GC identifers: GC02P108323 GC02P108230 GC02P102462


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SULT1C3 Gene:
SULT1C3 (sulfotransferase family, cytosolic, 1C, member 3) is a protein-coding gene. GO annotations related to this gene include aryl sulfotransferase activity and alcohol sulfotransferase activity. An important paralog of this gene is SULT4A1.

UniProtKB/Swiss-Prot: ST1C3_HUMAN, Q6IMI6
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low
sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate
conjugation of xenobiotic compounds and endogenous substrates

Gene Wiki entry for SULT1C3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SULT1C3 gene promoter:
         AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSULT1C3 promoter sequence
   Search Chromatin IP Primers for SULT1C3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SULT1C3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.3   Ensembl cytogenetic band:  2q12.3   HGNC cytogenetic band: 2q12.3

SULT1C3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT1C3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P108863:  view genomic region     (about GC identifiers)

Start:
108,863,651 bp from pter      End:
108,881,807 bp from pter
Size:
18,157 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ST1C3_HUMAN, Q6IMI6 (See protein sequence)
Recommended Name: Sulfotransferase 1C3  
Size: 304 amino acids; 35889 Da
2 PDB 3D structures from and Proteopedia for SULT1C3:
2H8K (3D)        2REO (3D)    
Secondary accessions: Q6IMI5
Alternative splicing: 2 isoforms:  Q6IMI6-1   Q6IMI6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SULT1C3: NX_Q6IMI6

Explore proteomics data for SULT1C3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SULT1C3 (Q6IMI6) (see all 5)
     SPFMRKG  LYLFYED  PKSGTTW  FTVAQNE 


    See SULT1C3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001008743.1  
    ENSEMBL proteins: 
     ENSP00000333310   ENSP00000365890  

    SULT1C3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for SULT1C3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULT: Sulfotransferases, cytosolic

    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry Q6IMI6

    ProtoNet protein and cluster: Q6IMI6

    1 Blocks protein domain: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST1C3_HUMAN, Q6IMI6
    Similarity: Belongs to the sulfotransferase 1 family


    SULT1C3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST1C3_HUMAN, Q6IMI6
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low
    sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate
    conjugation of xenobiotic compounds and endogenous substrates
    Catalytic activity: 3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate

         Enzyme Numbers (IUBMB): EC 2.8.22 EC 2.8.2.21 EC 2.8.2.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004027alcohol sulfotransferase activity IDA17936463
    GO:0004062aryl sulfotransferase activity IEA--
    GO:0008146sulfotransferase activity ----
         
    SULT1C3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SULT1C3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SULT1C3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SULT1C3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SULT1C3

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SULT1C3
    Predesigned siRNA for gene silencing in human, mouse, rat SULT1C3

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    GenScript: all cDNA clones in your preferred vector: SULT1C3 (NM_001008743)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SULT1C3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULT1C3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1C3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ST1C3_HUMAN, Q6IMI6: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    SULT1C3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SULT1C3 About    
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    metapathway biotransformation0.42
    2Sulfation Biotransformation Reaction
    Sulfation Biotransformation Reaction


    2 BioSystems Pathways for SULT1C3
        Sulfation Biotransformation Reaction
    metapathway biotransformation


        Pathway & Disease-focused RT2 Profiler PCR Array including SULT1C3: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SULT1C3

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006790sulfur compound metabolic process IEA--

    SULT1C3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SULT1C3 (ST1C3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SULT1C3 gene: 
    NM_001008743.1  

    Unigene Cluster for SULT1C3:

    Sulfotransferase family, cytosolic, 1C, member 3
    Hs.535156
    Unigene Representative Sequence: NM_001008743
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329106(uc010ywo.2) ENST00000376700
    miRNA
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    Block miRNA regulation of human, mouse, rat SULT1C3 using miScript Target Protectors
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat SULT1C3
    Clone
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    OriGene clones in human, mouse for SULT1C3 (see all 6)
    OriGene ORF clones in mouse, rat for SULT1C3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SULT1C3 (NM_001008743)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SULT1C3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULT1C3
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SULT1C3
      QuantiTect SYBR Green Assays in human, mouse, rat SULT1C3
      QuantiFast Probe-based Assays in human, mouse, rat SULT1C3

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SULT1C3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCGGATCC
    SULT1C3 Expression
    About this image

    SULT1C3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SULT1C3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.535156

    UniProtKB/Swiss-Prot: ST1C3_HUMAN, Q6IMI6
    Tissue specificity: Not detectable in any of the tissues tested

        Pathway & Disease-focused RT2 Profiler PCR Array including SULT1C3: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SULT1C3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SULT1C3
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    QuantiFast Probe-based Assays in human, mouse, rat SULT1C3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1C3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SULT1C3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sult1c11 , 5 sulfotransferase family, cytosolic, 1C, member 11, 5 74.32(n)1
    69.61(a)1
      17 (28.07 cM)5
    208881  NM_018751.21  NP_061221.21 
     539616155 
    chicken
    (Gallus gallus)
    Aves SULT1C31 sulfotransferase family, cytosolic, 1C, member 3 67.26(n)
    62.9(a)
      395300  NM_204601.2  NP_989932.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    many ↔ many
    GL343287.1(982410-988189)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004935281 sulfotransferase 1C2-like 66.87(n)
    57.93(a)
      100493528  XM_002944615.2  XP_002944661.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sult1st26
    sulfotransferase family 1, cytosolic sulfotransfer...
    46(a)
    many ↔ many
    8(48667606-48678955) ENSDARG00000041540
    fruit fly
    (Drosophila melanogaster)
    Insecta St26
    Sulfotransferase 2
    26(a)
    1 → many
    3R(5077565-5078845)


    ENSEMBL Gene Tree for SULT1C3 (if available)
    TreeFam Gene Tree for SULT1C3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SULT1C3 gene
    SULT4A12  SULT1B12  SULT1A22  SULT1C42  SULT1C22  SULT1E12  SULT2B12  SULT1A42  
    SULT2A12  SULT6B12  SULT1A12  SULT1A32  
    14 SIMAP similar genes for SULT1C3 using alignment to 1 protein entry:     ST1C3_HUMAN:
    STP1    SULT1E1    SULT1B1    SULT1C2    ST1A5    SULT1A4
    SULT1C4    SULT1A3    SULT1A1    SULT1A2    SULT2A1    SULT2B1
    SULT4A1    SULT6B1

    SULT1C3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SULT1C3
    PGOHUM00000237783 PGOHUM00000245584


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SULT1C3 (see all 422)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs133985191,2
    C,F,H--108861888(+) catagA/Gaaaag 1 -- us2k1 trp36Minor allele frequency- G:0.04NS EA WA NA 654
    rs1888263241,2
    --108861889(+) ATAGAA/CAAAGG 1 -- us2k10--------
    rs111236851,2
    C,F,A,H--108861908(+) taactT/Accaga 1 -- us2k1 tfbs310Minor allele frequency- A:0.18NS EA NA 658
    rs1463485141,2
    --108861928(+) CCTTTA/GCTAAT 1 -- us2k10--------
    rs111236861,2
    C,F,A,H--108861980(+) gaacaC/Tgggaa 1 -- us2k111Minor allele frequency- T:0.16NS EA NA WA 784
    rs76028871,2
    C,F,H--108862091(+) ctgcaC/Tacaac 1 -- us2k16Minor allele frequency- T:0.06NS EA CSA WA 536
    rs739517211,2
    C,F--108862099(+) AACGCG/AGGGAC 1 -- us2k12Minor allele frequency- A:0.05WA 120
    rs111236871,2
    C,F,A,H--108862111(+) ctgggC/Tctagt 1 -- us2k17Minor allele frequency- T:0.23NA EA 252
    rs1396926961,2
    --108862148(+) CTTCCA/GGGCCT 1 -- us2k10--------
    rs775645781,2
    C--108862365(+) CTGAAC/TGCCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SULT1C3 (108863651 - 108881807 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SULT1C3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720498CNV Deletion23290073
    dgv724e199CNV Deletion23128226
    nsv527491CNV Loss19592680
    nsv874770CNV Loss21882294
    nsv874769CNV Gain21882294
    nsv874771CNV Gain21882294
    nsv834327CNV Gain17160897
    nsv527686CNV Gain19592680
    dgv153e55CNV Gain17911159
    dgv1234e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): SULT1C3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SULT1C3
    DNA2.0 Custom Variant and Variant Library Synthesis for SULT1C3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    SULT1C3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SULT1C3
    Human Genome Epidemiology (HuGE) Navigator: SULT1C3 (1 document)

    Export disorders for SULT1C3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SULT1C3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SULT1C3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and chemical profiling of the human cytosolic sulfotransferases. (PubMed id 17425406)1, 2, 3 Allali-Hassani A.... Arrowsmith C.H. (PLoS Biol. 2007)
    2. Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. (PubMed id 14676822)1, 2, 3 Freimuth R.R.... Weinshilboum R.M. (Pharmacogenomics J. 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens. (PubMed id 17936463)1, 2 Meinl W.... Glatt H. (Food Chem. Toxicol. 2008)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 442038 HGNC: 33543 Ensembl:ENSG00000196228 euGenes: HUgn442038 ECgene: SULT1C3
    H-InvDB: SULT1C3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SULT1C3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SULT1C3 gene:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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