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Aliases for SULT1C3 Gene

Aliases for SULT1C3 Gene

  • Sulfotransferase Family, Cytosolic, 1C, Member 3 2 3
  • ST1C3 3 4
  • Sulfotransferase 1C3 3
  • EC 2.8.2.1 63
  • EC 2.8.2.2 4
  • EC 2.8.2 63

External Ids for SULT1C3 Gene

Previous GeneCards Identifiers for SULT1C3 Gene

  • GC02P108323
  • GC02P108863
  • GC02P102462

Summaries for SULT1C3 Gene

GeneCards Summary for SULT1C3 Gene

SULT1C3 (Sulfotransferase Family, Cytosolic, 1C, Member 3) is a Protein Coding gene. Among its related pathways are Biological oxidations and Sulfation Biotransformation Reaction. GO annotations related to this gene include aryl sulfotransferase activity and alcohol sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT1C3 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.

Gene Wiki entry for SULT1C3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1C3 Gene

Genomics for SULT1C3 Gene

Regulatory Elements for SULT1C3 Gene

Transcription factor binding sites by QIAGEN in the SULT1C3 gene promoter:

Genomic Location for SULT1C3 Gene

Start:
108,247,195 bp from pter
End:
108,265,351 bp from pter
Size:
18,157 bases
Orientation:
Plus strand

Genomic View for SULT1C3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SULT1C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1C3 Gene

Proteins for SULT1C3 Gene

  • Protein details for SULT1C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IMI6-ST1C3_HUMAN
    Recommended name:
    Sulfotransferase 1C3
    Protein Accession:
    Q6IMI6
    Secondary Accessions:
    • Q6IMI5

    Protein attributes for SULT1C3 Gene

    Size:
    304 amino acids
    Molecular mass:
    35889 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT1C3 Gene

    Alternative splice isoforms for SULT1C3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT1C3 Gene

Proteomics data for SULT1C3 Gene at MOPED

Selected DME Specific Peptides for SULT1C3 Gene

Post-translational modifications for SULT1C3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT1C3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for SULT1C3 Gene

Gene Families for SULT1C3 Gene

HGNC:
  • SULT :Sulfotransferases, cytosolic

Protein Domains for SULT1C3 Gene

Suggested Antigen Peptide Sequences for SULT1C3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IMI6

UniProtKB/Swiss-Prot:

ST1C3_HUMAN :
  • Q6IMI6
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1C3: view

Function for SULT1C3 Gene

Molecular function for SULT1C3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + an alcohol = adenosine 3,5-bisphosphate + an alkyl sulfate.
UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.

Enzyme Numbers (IUBMB) for SULT1C3 Gene

Gene Ontology (GO) - Molecular Function for SULT1C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004027 alcohol sulfotransferase activity IDA 17936463
GO:0004062 aryl sulfotransferase activity IEA --
GO:0008146 sulfotransferase activity --
genes like me logo Genes that share ontologies with SULT1C3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SULT1C3

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SULT1C3 Gene

Localization for SULT1C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1C3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT1C3 Gene COMPARTMENTS Subcellular localization image for SULT1C3 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for SULT1C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SULT1C3: view

Pathways for SULT1C3 Gene

genes like me logo Genes that share pathways with SULT1C3: view

Pathways by source for SULT1C3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat

Interacting Proteins for SULT1C3 Gene

Gene Ontology (GO) - Biological Process for SULT1C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006790 sulfur compound metabolic process IEA --
genes like me logo Genes that share ontologies with SULT1C3: view

Transcripts for SULT1C3 Gene

mRNA/cDNA for SULT1C3 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT1C3 Gene

Sulfotransferase family, cytosolic, 1C, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SULT1C3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SULT1C3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1C3 Gene

No ASD Table

Relevant External Links for SULT1C3 Gene

GeneLoc Exon Structure for
SULT1C3
ECgene alternative splicing isoforms for
SULT1C3

Expression for SULT1C3 Gene

mRNA expression in normal human tissues for SULT1C3 Gene

mRNA differential expression in normal tissues according to GTEx for SULT1C3 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (37.5) and Skin - Not Sun Exposed (Suprapubic) (6.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SULT1C3 Gene

SOURCE GeneReport for Unigene cluster for SULT1C3 Gene Hs.535156

mRNA Expression by UniProt/SwissProt for SULT1C3 Gene

Q6IMI6-ST1C3_HUMAN
Tissue specificity: Isoform 1 is not detectable in any of the tissues tested. Isoform 2 is expresssed in the small intestine.
genes like me logo Genes that share expressions with SULT1C3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SULT1C3 Gene

Orthologs for SULT1C3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1C3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100608286 35
  • 89.33 (n)
  • 84.16 (a)
SULT1C3 36
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SULT1C3 35
  • 71.02 (n)
  • 67.84 (a)
SULT1C3 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC481309 35
  • 74.88 (n)
  • 67.71 (a)
SULT1C3 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sult1c1 35
  • 74.32 (n)
  • 69.61 (a)
Sult1c1 16
Sult1c1 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SULT1C3 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SULT1C3 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sult1c3 35
  • 74.44 (n)
  • 69.26 (a)
chicken
(Gallus gallus)
Aves SULT1C 36
  • 59 (a)
OneToOne
SULT1C3 35
  • 67.26 (n)
  • 62.9 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493528 35
  • 66.87 (n)
  • 57.93 (a)
zebrafish
(Danio rerio)
Actinopterygii sult1st2 36
  • 46 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta St2 36
  • 26 (a)
OneToMany
Species with no ortholog for SULT1C3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT1C3 Gene

ENSEMBL:
Gene Tree for SULT1C3 (if available)
TreeFam:
Gene Tree for SULT1C3 (if available)

Paralogs for SULT1C3 Gene

Selected SIMAP similar genes for SULT1C3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SULT1C3 Gene

genes like me logo Genes that share paralogs with SULT1C3: view

Variants for SULT1C3 Gene

Sequence variations from dbSNP and Humsavar for SULT1C3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1470874 -- 108,262,255(+) TTAGA(A/G)AGCTC intron-variant
rs2198463 -- 108,258,637(+) AACGA(A/T)AGTTA intron-variant
rs2219078 - 108,258,742(+) TTGGC(A/G)GGTCC missense, reference
rs2219079 -- 108,263,283(+) ggaaa(C/T)gccta intron-variant
rs4141931 -- 108,260,492(+) TAGGC(C/T)TAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULT1C3 Gene

Variant ID Type Subtype PubMed ID
esv2720498 CNV Deletion 23290073
dgv1233e1 CNV Complex 17122850
dgv1234e1 CNV Complex 17122850
dgv724e199 CNV Deletion 23128226
nsv874769 CNV Gain 21882294
nsv874770 CNV Loss 21882294
nsv527686 CNV Gain 19592680
dgv153e55 CNV Gain 17911159
nsv527491 CNV Loss 19592680
nsv874771 CNV Gain 21882294
nsv834327 CNV Gain 17160897

Relevant External Links for SULT1C3 Gene

HapMap Linkage Disequilibrium report
SULT1C3
Human Gene Mutation Database (HGMD)
SULT1C3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1C3 Gene

Disorders for SULT1C3 Gene

Relevant External Links for SULT1C3

Genetic Association Database (GAD)
SULT1C3
Human Genome Epidemiology (HuGE) Navigator
SULT1C3
genes like me logo Genes that share disorders with SULT1C3: view

No data available for UniProtKB/Swiss-Prot for SULT1C3 Gene

Publications for SULT1C3 Gene

  1. Structural and chemical profiling of the human cytosolic sulfotransferases. (PMID: 17425406) Allali-Hassani A. … Arrowsmith C.H. (PLoS Biol. 2007) 2 3 4
  2. Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. (PMID: 14676822) Freimuth R.R. … Weinshilboum R.M. (Pharmacogenomics J. 2004) 2 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function. (PMID: 24335392) Duniec-Dmuchowski Z. … Kocarek T.A. (Drug Metab. Dispos. 2014) 3 4
  5. SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens. (PMID: 17936463) Meinl W. … Glatt H. (Food Chem. Toxicol. 2008) 3 4

Products for SULT1C3 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SULT1C3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SULT1C3
    • Block miRNA regulation of SULT1C3 using miScript Target Protectors

    Sources for SULT1C3 Gene

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