Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SULT1C3 Gene

Aliases for SULT1C3 Gene

  • Sulfotransferase Family 1C Member 3 2 3 5
  • Sulfotransferase Family, Cytosolic, 1C, Member 3 2 3
  • ST1C3 3 4
  • Sulfotransferase 1C3 3
  • EC 56
  • EC 4
  • EC 2.8.2 56

External Ids for SULT1C3 Gene

Previous GeneCards Identifiers for SULT1C3 Gene

  • GC02P108323
  • GC02P108863
  • GC02P102462

Summaries for SULT1C3 Gene

GeneCards Summary for SULT1C3 Gene

SULT1C3 (Sulfotransferase Family 1C Member 3) is a Protein Coding gene. Among its related pathways are Sulfation Biotransformation Reaction and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and alcohol sulfotransferase activity. An important paralog of this gene is SULT1C4.

UniProtKB/Swiss-Prot for SULT1C3 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.

Gene Wiki entry for SULT1C3 Gene

Additional gene information for SULT1C3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1C3 Gene

Genomics for SULT1C3 Gene

GeneHancer (GH) Regulatory Elements for SULT1C3 Gene

Promoters and enhancers for SULT1C3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I108238 Enhancer 0.3 ENCODE 550.8 -0.4 -407 1.7 FOXA1 SULT1C3 SULT1C2 LINC01594 GC02P108069
GH02I108265 Enhancer 1.1 Ensembl ENCODE dbSUPER 22.1 +27.3 27264 3.3 DRAP1 ELF3 FOXA2 SAP130 ZFP64 CEBPG FOSL2 FOS HOMEZ THAP11 SULT1C2 SULT1C3 LINC01594 WASF1P1
GH02I108286 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 10.1 +49.0 48971 4.4 FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF121 GLIS2 RXRA SP5 NFYC SULT1C2 SULT1C3 PIR51121
GH02I108269 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.7 +31.1 31121 3.6 ELF3 HDGF PKNOX1 FOXA2 ARID4B DMAP1 ZBTB40 ZNF48 THAP11 ELF1 SULT1C2 LINC01594 SULT1C3 WASF1P1
GH02I108293 Enhancer 0.6 dbSUPER 11 +55.0 54975 3.2 NCOA3 GATAD2A FOXA2 HLF CEBPG ZNF644 FOXA1 ZNF217 CTBP1 GATA3 SULT1C2 LINC01594 SULT1C3 PIR51121
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SULT1C3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SULT1C3 gene promoter:

Genomic Locations for SULT1C3 Gene

Genomic Locations for SULT1C3 Gene
25,635 bases
Plus strand

Genomic View for SULT1C3 Gene

Genes around SULT1C3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1C3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1C3 Gene

Proteins for SULT1C3 Gene

  • Protein details for SULT1C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sulfotransferase 1C3
    Protein Accession:
    Secondary Accessions:
    • Q6IMI5

    Protein attributes for SULT1C3 Gene

    304 amino acids
    Molecular mass:
    35889 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT1C3 Gene

    Alternative splice isoforms for SULT1C3 Gene


neXtProt entry for SULT1C3 Gene

Selected DME Specific Peptides for SULT1C3 Gene


Post-translational modifications for SULT1C3 Gene

No Post-translational modifications

Other Protein References for SULT1C3 Gene

Domains & Families for SULT1C3 Gene

Gene Families for SULT1C3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SULT1C3 Gene

Suggested Antigen Peptide Sequences for SULT1C3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfotransferase 1 family.
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1C3: view

Function for SULT1C3 Gene

Molecular function for SULT1C3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + an alcohol = adenosine 3,5-bisphosphate + an alkyl sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.

Enzyme Numbers (IUBMB) for SULT1C3 Gene

Phenotypes From GWAS Catalog for SULT1C3 Gene

Gene Ontology (GO) - Molecular Function for SULT1C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004027 alcohol sulfotransferase activity IDA 17936463
GO:0004062 aryl sulfotransferase activity IEA --
GO:0008146 sulfotransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SULT1C3: view

Phenotypes for SULT1C3 Gene

genes like me logo Genes that share phenotypes with SULT1C3: view

Animal Models for SULT1C3 Gene

MGI Knock Outs for SULT1C3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SULT1C3 Gene

Localization for SULT1C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1C3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT1C3 gene
Compartment Confidence
cytosol 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SULT1C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SULT1C3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SULT1C3 Gene

Pathways & Interactions for SULT1C3 Gene

genes like me logo Genes that share pathways with SULT1C3: view

Pathways by source for SULT1C3 Gene

Gene Ontology (GO) - Biological Process for SULT1C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006790 sulfur compound metabolic process IEA --
genes like me logo Genes that share ontologies with SULT1C3: view

No data available for SIGNOR curated interactions for SULT1C3 Gene

Drugs & Compounds for SULT1C3 Gene

(2) Additional Compounds for SULT1C3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
genes like me logo Genes that share compounds with SULT1C3: view

Transcripts for SULT1C3 Gene

mRNA/cDNA for SULT1C3 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT1C3 Gene

Sulfotransferase family, cytosolic, 1C, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1C3 Gene

No ASD Table

Relevant External Links for SULT1C3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SULT1C3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SULT1C3 Gene

mRNA differential expression in normal tissues according to GTEx for SULT1C3 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x37.5) and Skin - Not Sun Exposed (Suprapubic) (x6.0).

Protein differential expression in normal tissues from HIPED for SULT1C3 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SULT1C3 Gene

Protein tissue co-expression partners for SULT1C3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SULT1C3 Gene:


SOURCE GeneReport for Unigene cluster for SULT1C3 Gene:


mRNA Expression by UniProt/SwissProt for SULT1C3 Gene:

Tissue specificity: Isoform 1 is not detectable in any of the tissues tested. Isoform 2 is expressed in the small intestine.
genes like me logo Genes that share expression patterns with SULT1C3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT1C3 Gene

Orthologs for SULT1C3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1C3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100608286 33
  • 89.33 (n)
SULT1C3 34
  • 87 (a)
(Canis familiaris)
Mammalia LOC481309 33
  • 74.88 (n)
SULT1C3 34
  • 64 (a)
(Rattus norvegicus)
Mammalia Sult1c3 33
  • 74.44 (n)
(Mus musculus)
Mammalia Sult1c1 33 16 34
  • 74.32 (n)
(Bos Taurus)
Mammalia SULT1C3 33 34
  • 71.02 (n)
(Monodelphis domestica)
Mammalia SULT1C3 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia SULT1C3 34
  • 58 (a)
(Gallus gallus)
Aves SULT1C3 33
  • 67.26 (n)
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493528 33
  • 66.87 (n)
(Danio rerio)
Actinopterygii sult1st2 34
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta St2 34
  • 26 (a)
Species where no ortholog for SULT1C3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT1C3 Gene

Gene Tree for SULT1C3 (if available)
Gene Tree for SULT1C3 (if available)

Paralogs for SULT1C3 Gene

(14) SIMAP similar genes for SULT1C3 Gene using alignment to 1 proteins: Pseudogenes for SULT1C3 Gene

genes like me logo Genes that share paralogs with SULT1C3: view

Variants for SULT1C3 Gene

Sequence variations from dbSNP and Humsavar for SULT1C3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs112050262 benign, not specified 108,247,302(+) G/A coding_sequence_variant, stop_gained
rs1000012149 -- 108,261,664(+) A/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000197468 -- 108,244,832(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000227502 -- 108,252,178(+) GAT/GATGGAT intron_variant
rs1000254799 -- 108,255,326(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SULT1C3 Gene

Variant ID Type Subtype PubMed ID
dgv153e55 CNV gain 17911159
dgv4034n100 CNV gain 25217958
dgv4035n100 CNV gain 25217958
dgv4036n100 CNV gain 25217958
dgv724e199 CNV deletion 23128226
esv2720498 CNV deletion 23290073
esv2759081 CNV gain 17122850
esv3591913 CNV gain 21293372
nsv527491 CNV loss 19592680
nsv527686 CNV gain 19592680
nsv834327 CNV gain 17160897

Variation tolerance for SULT1C3 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.44; 95.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SULT1C3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1C3 Gene

Disorders for SULT1C3 Gene

Additional Disease Information for SULT1C3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SULT1C3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SULT1C3 Gene

Publications for SULT1C3 Gene

  1. Structural and chemical profiling of the human cytosolic sulfotransferases. (PMID: 17425406) Allali-Hassani A … Arrowsmith CH (PLoS biology 2007) 2 3 4 58
  2. Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. (PMID: 14676822) Freimuth RR … Weinshilboum RM (The pharmacogenomics journal 2004) 2 3 4 58
  3. Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function. (PMID: 24335392) Duniec-Dmuchowski Z … Kocarek TA (Drug metabolism and disposition: the biological fate of chemicals 2014) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens. (PMID: 17936463) Meinl W … Glatt H (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008) 3 4 58

Products for SULT1C3 Gene

Sources for SULT1C3 Gene

Loading form....