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Aliases for SULT1C2 Gene

Aliases for SULT1C2 Gene

  • Sulfotransferase Family 1C Member 2 2 3 5
  • Sulfotransferase Family, Cytosolic, 1C, Member 1 2 3
  • Sulfotransferase Family, Cytosolic, 1C, Member 2 2 3
  • Sulfotransferase 1C1 3 4
  • HumSULTC2 3 4
  • SULT1C#1 3 4
  • SULT1C1 3 4
  • ST1C2 3 4
  • Sulfotransferase 1C2 3
  • EC 2.8.2.1 61
  • EC 2.8.2.2 61
  • EC 2.8.2.- 4
  • EC 2.8.2 61
  • ST1C1 3

External Ids for SULT1C2 Gene

Previous HGNC Symbols for SULT1C2 Gene

  • SULT1C1

Previous GeneCards Identifiers for SULT1C2 Gene

  • GC02P106899
  • GC02P107474
  • GC02P108469
  • GC02P108486
  • GC02P108488
  • GC02P108452
  • GC02P108272
  • GC02P108905
  • GC02P102504

Summaries for SULT1C2 Gene

Entrez Gene Summary for SULT1C2 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1C2 Gene

SULT1C2 (Sulfotransferase Family 1C Member 2) is a Protein Coding gene. Diseases associated with SULT1C2 include Colon Mucinous Adenocarcinoma and Spherocytosis, Type 3. Among its related pathways are Cytochrome P450 - arranged by substrate type and Sulfation Biotransformation Reaction. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1C4.

UniProtKB/Swiss-Prot for SULT1C2 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).

Gene Wiki entry for SULT1C2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1C2 Gene

Genomics for SULT1C2 Gene

Regulatory Elements for SULT1C2 Gene

Enhancers for SULT1C2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G108286 1.5 Ensembl ENCODE dbSUPER 53.4 +0.3 307 4.4 FOXA2 MLX ARID4B FEZF1 DMAP1 YY1 ZNF121 GLIS2 ZNF263 SP5 SULT1C2 SULT1C3 PIR51121
GH02G108265 1.3 Ensembl ENCODE dbSUPER 36.3 -21.4 -21402 3.3 ELF3 HNRNPUL1 DRAP1 FOXA2 SAP130 ZFP64 CEBPG FOS HOMEZ MIXL1 SULT1C2 SULT1C3 LINC01594 WASF1P1
GH02G108293 0.7 dbSUPER 39.6 +6.3 6311 3.2 GATAD2A FOXA2 HLF CEBPG ZNF644 FOXA1 CTBP1 ATF4 GATA3 ZNF316 SULT1C2 LINC01594 SULT1C3 PIR51121
GH02G108269 1.4 Ensembl ENCODE dbSUPER 18.6 -17.5 -17544 3.6 ELF3 HDGF PKNOX1 FOXA2 ARID4B DMAP1 ZBTB40 ZNF48 THAP11 CEBPB SULT1C2 LINC01594 SULT1C3 WASF1P1
GH02G108295 0.6 dbSUPER 39.6 +7.2 7214 1.4 CTBP1 ZNF316 GATA3 FOXA2 MAFK FOXA1 SULT1C2 LINC01594 SULT1C3 PIR51121
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SULT1C2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SULT1C2 Gene

Chromosome:
2
Start:
108,288,639 bp from pter
End:
108,310,569 bp from pter
Size:
21,931 bases
Orientation:
Plus strand

Genomic View for SULT1C2 Gene

Genes around SULT1C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1C2 Gene

Proteins for SULT1C2 Gene

  • Protein details for SULT1C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00338-ST1C2_HUMAN
    Recommended name:
    Sulfotransferase 1C2
    Protein Accession:
    O00338
    Secondary Accessions:
    • B2R813
    • Q53SG4

    Protein attributes for SULT1C2 Gene

    Size:
    296 amino acids
    Molecular mass:
    34880 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT1C2 Gene

    Alternative splice isoforms for SULT1C2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT1C2 Gene

Selected DME Specific Peptides for SULT1C2 Gene

O00338:
  • WGSWFDHVKGWWE
  • FTVAQNE
  • RKGTVGDWKNHFTVAQ
  • GDWKNHFTVAQ
  • YVARNAKD
  • SFWENNCK
  • KDCMVSYYHF
  • ETSFEKMK
  • RHPFIEW
  • EYFETFINGKV

Post-translational modifications for SULT1C2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for SULT1C2 Gene

Gene Families for SULT1C2 Gene

Protein Domains for SULT1C2 Gene

Suggested Antigen Peptide Sequences for SULT1C2 Gene

Graphical View of Domain Structure for InterPro Entry

O00338

UniProtKB/Swiss-Prot:

ST1C2_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1C2: view

Function for SULT1C2 Gene

Molecular function for SULT1C2 Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).

Enzyme Numbers (IUBMB) for SULT1C2 Gene

Gene Ontology (GO) - Molecular Function for SULT1C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity TAS --
GO:0005515 protein binding IPI 21044950
GO:0008146 sulfotransferase activity TAS,IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SULT1C2: view
genes like me logo Genes that share phenotypes with SULT1C2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SULT1C2

miRNA for SULT1C2 Gene

miRTarBase miRNAs that target SULT1C2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SULT1C2 Gene

Localization for SULT1C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1C2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT1C2 gene
Compartment Confidence
extracellular 5
cytosol 5
peroxisome 2
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SULT1C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,TAS 9169148
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SULT1C2: view

Pathways & Interactions for SULT1C2 Gene

genes like me logo Genes that share pathways with SULT1C2: view

Pathways by source for SULT1C2 Gene

Gene Ontology (GO) - Biological Process for SULT1C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009308 amine metabolic process TAS 9169148
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
GO:0051923 sulfation IDA,IEA 19548878
genes like me logo Genes that share ontologies with SULT1C2: view

No data available for SIGNOR curated interactions for SULT1C2 Gene

Drugs & Compounds for SULT1C2 Gene

(1) Additional Compounds for SULT1C2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SULT1C2: view

Transcripts for SULT1C2 Gene

Unigene Clusters for SULT1C2 Gene

Sulfotransferase family, cytosolic, 1C, member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1C2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - -

Relevant External Links for SULT1C2 Gene

GeneLoc Exon Structure for
SULT1C2
ECgene alternative splicing isoforms for
SULT1C2

Expression for SULT1C2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SULT1C2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT1C2 Gene

This gene is overexpressed in Kidney - Cortex (x19.8), Stomach (x17.8), and Thyroid (x5.1).

Protein differential expression in normal tissues from HIPED for SULT1C2 Gene

This gene is overexpressed in Stomach (38.5), Kidney (10.9), and Cardia (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SULT1C2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SULT1C2 Gene:

SULT1C2

SOURCE GeneReport for Unigene cluster for SULT1C2 Gene:

Hs.436123

mRNA Expression by UniProt/SwissProt for SULT1C2 Gene:

O00338-ST1C2_HUMAN
Tissue specificity: Found in adult stomach, kidney and thyroid gland, and in fetal kidney and liver.

Evidence on tissue expression from TISSUES for SULT1C2 Gene

  • Kidney(4.6)
  • Stomach(4.5)
  • Lung(4.3)
  • Spleen(4)
  • Liver(2.3)
  • Intestine(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with SULT1C2: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT1C2 Gene

Orthologs for SULT1C2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1C2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT1C2 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia SULT1C2 34 35
  • 85.96 (n)
mouse
(Mus musculus)
Mammalia Sult1c2 34 16 35
  • 82.21 (n)
cow
(Bos Taurus)
Mammalia SULT1C2 34 35
  • 79.59 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SULT1C2 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sult1b1 34
  • 58.68 (n)
Str.1113 34
African clawed frog
(Xenopus laevis)
Amphibia sult1c1-prov 34
zebrafish
(Danio rerio)
Actinopterygii sult1st6 34 35
  • 58.59 (n)
sult1st1 35
  • 41 (a)
ManyToMany
sult1st3 35
  • 41 (a)
ManyToMany
sult1st7 35
  • 41 (a)
ManyToMany
sult1st8 35
  • 41 (a)
ManyToMany
sult1st4 35
  • 40 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5428 36
  • 34 (a)
CG6704 36
  • 32 (a)
CG16733 36
  • 29 (a)
St2 35
  • 29 (a)
OneToMany
Species where no ortholog for SULT1C2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT1C2 Gene

ENSEMBL:
Gene Tree for SULT1C2 (if available)
TreeFam:
Gene Tree for SULT1C2 (if available)

Paralogs for SULT1C2 Gene

Pseudogenes.org Pseudogenes for SULT1C2 Gene

genes like me logo Genes that share paralogs with SULT1C2: view

Variants for SULT1C2 Gene

Sequence variations from dbSNP and Humsavar for SULT1C2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000066197 -- 108,301,815(+) CAAAC(C/T)GAGCC intron-variant
rs1000094579 -- 108,292,044(+) CTGGG(C/T)ACCTA intron-variant
rs1000165224 -- 108,310,353(+) AATAA(C/T)TTTAA downstream-variant-500B
rs1000258913 -- 108,288,837(+) GGCCA(A/G)GTCAC utr-variant-5-prime
rs1000299760 -- 108,289,090(+) TAAAA(G/T)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULT1C2 Gene

Variant ID Type Subtype PubMed ID
dgv153e55 CNV gain 17911159
dgv4034n100 CNV gain 25217958
dgv4035n100 CNV gain 25217958
dgv4036n100 CNV gain 25217958
dgv724e199 CNV deletion 23128226
esv2720498 CNV deletion 23290073
esv2759081 CNV gain 17122850
esv3591913 CNV gain 21293372
esv3591924 CNV gain 21293372
nsv1005832 CNV gain 25217958
nsv10112 CNV gain 18304495
nsv527491 CNV loss 19592680
nsv527686 CNV gain 19592680
nsv582640 CNV loss 21841781
nsv834327 CNV gain 17160897

Variation tolerance for SULT1C2 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULT1C2 Gene

Human Gene Mutation Database (HGMD)
SULT1C2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT1C2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1C2 Gene

Disorders for SULT1C2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SULT1C2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
colon mucinous adenocarcinoma
  • colonic mucinous adenocarcinoma
spherocytosis, type 3
  • hereditary spherocytosis type 3
hereditary spherocytosis type 2
  • hereditary spherocytosis 2
stromal dystrophy
desbuquois dysplasia
  • desbuquois syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SULT1C2

Genetic Association Database (GAD)
SULT1C2
Human Genome Epidemiology (HuGE) Navigator
SULT1C2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SULT1C2
genes like me logo Genes that share disorders with SULT1C2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT1C2 Gene

Publications for SULT1C2 Gene

  1. Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization. (PMID: 10783263) Freimuth R.R. … Weinshilboum R.M. (Genomics 2000) 2 3 4 22 64
  2. Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization. (PMID: 9169148) Her C. … Weinshilboum R.M. (Genomics 1997) 2 3 4 22 64
  3. Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). (PMID: 16804942) Dombrovski L. … Plotnikov A.N. (Proteins 2006) 3 4 22 64
  4. Molecular characterization of ST1C1-related human sulfotransferase. (PMID: 9635888) Yoshinari K. … Yamazoe Y. (Carcinogenesis 1998) 3 4 22 64
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 46 64

Products for SULT1C2 Gene

Sources for SULT1C2 Gene

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