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SULT1C2 Gene

protein-coding   GIFtS: 60
GCID: GC02P108905

Sulfotransferase Family, Cytosolic, 1C, Member 2

(Previous names: sulfotransferase family, cytosolic, 1C, member 1)
(Previous symbol: SULT1C1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sulfotransferase Family, Cytosolic, 1C, Member 21 2     ST1C12
SULT1C11 2 3 5     Sulfotransferase 1C22
Sulfotransferase Family, Cytosolic, 1C, Member 11 2     EC 2.8.2.-3
Sulfotransferase 1C12 3     EC 2.8.28
ST1C22 3     EC 2.8.2.18
SULT1C#12 3     EC 2.8.2.28
humSULTC22 3     

External Ids:    HGNC: 114561   Entrez Gene: 68192   Ensembl: ENSG000001982037   OMIM: 6023855   UniProtKB: O003383   

Export aliases for SULT1C2 gene to outside databases

Previous GC identifers: GC02P106899 GC02P107474 GC02P108469 GC02P108486 GC02P108488 GC02P108452 GC02P108272 GC02P102504


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SULT1C2 Gene:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and
xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate
specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes
a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to
phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been
described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SULT1C2 Gene:
SULT1C2 (sulfotransferase family, cytosolic, 1C, member 2) is a protein-coding gene. Diseases associated with SULT1C2 include choroiditis, and esophagitis. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1C3.

UniProtKB/Swiss-Prot: ST1C2_HUMAN, O00338
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the
activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and
N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF)

Gene Wiki entry for SULT1C2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SULT1C2 gene promoter:
         GR   Pbx1a   AP-4   CUTL1   C/EBPalpha   YY1   Zic1   GR-alpha   ZIC2/Zic2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSULT1C2 promoter sequence
   Search Chromatin IP Primers for SULT1C2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SULT1C2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.3   Ensembl cytogenetic band:  2q12.3   HGNC cytogenetic band: 2q12.3

SULT1C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT1C2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P108905:  view genomic region     (about GC identifiers)

Start:
108,905,095 bp from pter      End:
108,926,371 bp from pter
Size:
21,277 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ST1C2_HUMAN, O00338 (See protein sequence)
Recommended Name: Sulfotransferase 1C2  
Size: 296 amino acids; 34880 Da
1 PDB 3D structure from and Proteopedia for SULT1C2:
3BFX (3D)    
Secondary accessions: B2R813 Q53SG4
Alternative splicing: 2 isoforms:  O00338-1   O00338-2   

Explore the universe of human proteins at neXtProt for SULT1C2: NX_O00338

Explore proteomics data for SULT1C2 at MOPED

Selected DME Specific Peptides for SULT1C2 (O00338) (see all 10)
 RHPFIEW  FTVAQNE  ETSFEKMK  SFWENNCK 


See SULT1C2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001047.1  NP_789795.1  

ENSEMBL proteins: 
 ENSP00000251481   ENSP00000319622   ENSP00000401996   ENSP00000387054   ENSP00000399651  
 ENSP00000415194   ENSP00000387340  
Reactome Protein details: O00338

SULT1C2 Human Recombinant Protein Products:

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Cloud-Clone Corp. CLIAs for SULT1C2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SULT: Sulfotransferases, cytosolic

2 InterPro protein domains:
 IPR027417 P-loop_NTPase
 IPR000863 Sulfotransferase_dom

Graphical View of Domain Structure for InterPro Entry O00338

ProtoNet protein and cluster: O00338

1 Blocks protein domain: IPB000863 Sulfotransferase

UniProtKB/Swiss-Prot: ST1C2_HUMAN, O00338
Similarity: Belongs to the sulfotransferase 1 family


SULT1C2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ST1C2_HUMAN, O00338
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the
activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and
N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF)

     Enzyme Numbers (IUBMB): EC 2.8.2.-1 EC 2.8.22 EC 2.8.2.22 EC 2.8.2.12

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008146sulfotransferase activity IDA--
     
SULT1C2 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SULT1C2
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SULT1C2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SULT1C2

miRNA
Products:
    
miRTarBase miRNAs that target SULT1C2:
hsa-mir-7-5p (MIRT025896), hsa-mir-335-5p (MIRT019095)

Block miRNA regulation of human, mouse, rat SULT1C2 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate SULT1C2:
hsa-miR-127-5p hsa-miR-186
SwitchGear 3'UTR luciferase reporter plasmidSULT1C2 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for SULT1C2
Predesigned siRNA for gene silencing in human, mouse, rat SULT1C2

Gene Editing
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GenScript: all cDNA clones in your preferred vector (see all 2): SULT1C2 (NM_001056)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SULT1C2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULT1C2

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1C2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ST1C2_HUMAN, O00338: Cytoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton4
cytosol4
peroxisome2
mitochondrion1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm TAS9169148
GO:0005829cytosol TAS--
GO:0015630microtubule cytoskeleton ----

SULT1C2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SULT1C2 About    
See pathways by source

SuperPathContained pathways About
1Biological oxidations
Biological oxidations0.56
metapathway biotransformation0.42
Phase II conjugation0.56
Cytosolic sulfonation of small molecules0.00
2Metabolism
Metabolism0.38
3Sulfation Biotransformation Reaction
Sulfation Biotransformation Reaction

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 BioSystems Pathways for SULT1C2
    Sulfation Biotransformation Reaction
metapathway biotransformation

1 Reactome Pathway for SULT1C2
    Cytosolic sulfonation of small molecules



SULT1C2 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including SULT1C2: 
          Drug Metabolism: Phase II Enzymes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for SULT1C2

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for SULT1C2 (ENSP000003196224) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
ACDENSP000003774964STRING: ENSP00000377496
POT1ENSP000003502494STRING: ENSP00000350249
TERF1ENSP000002766034STRING: ENSP00000276603
TINF2ENSP000002674154STRING: ENSP00000267415
HLTFENSP000003089444STRING: ENSP00000308944
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006805xenobiotic metabolic process TAS--
GO:0009308amine metabolic process TAS9169148
GO:0044281small molecule metabolic process TAS--
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process TAS--
GO:0051923sulfation IDA--

SULT1C2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SULT1C2 (ST1C2)

1 Novoseek inferred chemical compound relationship for SULT1C2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
n-hydroxy-2-acetylaminofluorene 86.7 2 9202764 (1)



SULT1C2 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SULT1C2 gene (2 alternative transcripts): 
NM_001056.3  NM_176825.2  

Unigene Cluster for SULT1C2:

Sulfotransferase family, cytosolic, 1C, member 2
Hs.436123  [show with all ESTs]
Unigene Representative Sequence: NM_176825
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000251481(uc010ywp.1 uc002tdy.3 uc010ywq.2) ENST00000326853(uc002tdx.3)
ENST00000438339 ENST00000409880 ENST00000437390 ENST00000442801 ENST00000409067
ENST00000492554 ENST00000495441
miRNA
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Block miRNA regulation of human, mouse, rat SULT1C2 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate SULT1C2:
hsa-miR-127-5p hsa-miR-186
SwitchGear 3'UTR luciferase reporter plasmidSULT1C2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SULT1C2
Predesigned siRNA for gene silencing in human, mouse, rat SULT1C2
Clone
Products:
     
OriGene clones in human, mouse for SULT1C2 (see all 11)
OriGene ORF clones in mouse, rat for SULT1C2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): SULT1C2 (NM_001056)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SULT1C2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SULT1C2
Primer
Products:
    
OriGene qPCR primer pairs and template standards for SULT1C2
OriGene qSTAR qPCR primer pairs in human, mouse for SULT1C2
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SULT1C2
  QuantiTect SYBR Green Assays in human, mouse, rat SULT1C2
  QuantiFast Probe-based Assays in human, mouse, rat SULT1C2

Additional mRNA sequence: 

AB008164.1 AF026303.1 AF186251.1 AF186252.1 AF186253.1 AF186254.1 AF186255.1 AF186256.1 
AK297086.1 AK298306.1 AK313193.1 BC005353.1 BT006951.1 U66036.1 

5 DOTS entries:

DT.114500  DT.100741191  DT.100741193  DT.101980628  DT.40206903 

Selected AceView cDNA sequences (see all 99):

BC005353 AF186255 AA360014 AA865827 AF186256 BX116663 AW466907 U66036 
AA385029 AW168079 W88655 AF186251 AF186254 CA394967 AF186252 CD014001 
AW296125 CD014002 AF186253 BM856476 CD014003 W88899 AL698074 AF026303 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for SULT1C2 (see all 6)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1:                                            -     -                                             
SP2:                                      -     -                                                   
SP3:                                      -                                                         
SP4:                                      -     -     -     -     -                                 
SP5:                                      -     -     -     -                                       


ECgene alternative splicing isoforms for SULT1C2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SULT1C2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAACTCTGAG
SULT1C2 Expression
About this image


SULT1C2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Epithelial Cells
         Mature Choroid Plexus Cells Choroid Plexus
 
 Brain (Nervous System)
         Mature Choroid Plexus Cells Choroid Plexus
 
 Kidney (Urinary System)
 
 Stomach (Gastrointestinal Tract)
SULT1C2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SULT1C2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.436123

UniProtKB/Swiss-Prot: ST1C2_HUMAN, O00338
Tissue specificity: Found in adult stomach, kidney and thyroid gland, and in fetal kidney and liver

    Pathway & Disease-focused RT2 Profiler PCR Array including SULT1C2: 
          Drug Metabolism: Phase II Enzymes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for SULT1C2
OriGene qSTAR qPCR primer pairs in human, mouse for SULT1C2
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SULT1C2
QuantiTect SYBR Green Assays in human, mouse, rat SULT1C2
QuantiFast Probe-based Assays in human, mouse, rat SULT1C2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1C2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SULT1C2 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Sult1c21 , 5 sulfotransferase family, cytosolic, 1C, member 21, 5 82.21(n)1
79.39(a)1
  17 (28.00 cM)5
690831  NM_026935.41  NP_081211.31 
 538296375 
lizard
(Anolis carolinensis)
Reptilia SULT1C26
sulfotransferase family, cytosolic, 1C, member 2
65(a)
1 ↔ 1
GL343220.1(2235690-2245861)
African clawed frog
(Xenopus laevis)
Amphibia sult1c1-prov2 sulfotransferase family 1A, phenol-preferring, member more 77.66(n)    BC043790.1 
zebrafish
(Danio rerio)
Actinopterygii AY196986.12   -- 72.54(n)    AY196986.1 
fruit fly
(Drosophila melanogaster)
Insecta CG54283 sulfotransferase 34(a)
(best of 3)
  59F6   --


ENSEMBL Gene Tree for SULT1C2 (if available)
TreeFam Gene Tree for SULT1C2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SULT1C2 gene
SULT1C32  SULT4A12  SULT1B12  SULT1A22  SULT1C42  SULT1E12  SULT2B12  SULT1A42  
SULT2A12  SULT6B12  SULT1A12  SULT1A32  
14 SIMAP similar genes for SULT1C2 using alignment to 6 protein entries:     ST1C2_HUMAN (see all proteins):
SULT1B1    STP1    SULT1C3    SULT1E1    SULT1A4    ST1A5
SULT1C4    SULT1A3    SULT1A1    SULT1A2    SULT2A1    SULT2B1
SULT6B1    SULT4A1

SULT1C2 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for SULT1C2
PGOHUM00000247762 PGOHUM00000240839


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SULT1C2 (see all 541)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1919500521,2
--108903122(+) TGTACA/GCTTGG 2 -- us2k10--------
rs1140856711,2
C,F--108903210(+) GCTTCC/TAGCTA 2 -- us2k11Minor allele frequency- T:0.04WA 118
rs1146116041,2
C,F--108903272(+) GACTCT/CATGGA 2 -- us2k11Minor allele frequency- C:0.01WA 118
rs170359991,2
C,F,H--108903370(+) GTGTGC/GCAGGC 2 -- us2k18Minor allele frequency- G:0.01NA NS EA WA 678
rs1404356001,2
C--108903485(+) TGTGGG/TGCCCA 2 -- us2k10--------
rs1838181851,2
--108903542(+) AGGAGG/TCTTGA 2 -- us2k10--------
rs729411461,2
C,F--108903546(+) GGCTTG/AAAGTA 2 -- us2k13Minor allele frequency- A:0.19WA 122
rs1883139881,2
--108903698(+) AAGCAC/TCCAGA 2 -- us2k10--------
rs1918003261,2
--108903718(+) ATAAAC/TAACCA 2 -- us2k10--------
rs1172045661,2
C,F--108903781(+) ACTAGT/CAGGGA 2 -- us2k11Minor allele frequency- C:0.02EA 120

HapMap Linkage Disequilibrium report for SULT1C2 (108905095 - 108926371 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for SULT1C2 (see all 12):    About this table    
Variant IDTypeSubtypePubMed ID
esv2720498CNV Deletion23290073
dgv724e199CNV Deletion23128226
nsv527491CNV Loss19592680
nsv874770CNV Loss21882294
nsv874769CNV Gain21882294
nsv10112CNV Gain18304495
nsv874771CNV Gain21882294
nsv834327CNV Gain17160897
nsv527686CNV Gain19592680
dgv153e55CNV Gain17911159

Human Gene Mutation Database (HGMD): SULT1C2
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SULT1C2
DNA2.0 Custom Variant and Variant Library Synthesis for SULT1C2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602385    OMIM disorders: --

6 diseases for SULT1C2:    
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choroiditis    esophagitis    adenocarcinoma    thyroiditis
hepatitis    leukemia


SULT1C2 for disorders           About GeneDecksing

Genetic Association Database (GAD): SULT1C2
Human Genome Epidemiology (HuGE) Navigator: SULT1C2 (2 documents)

Export disorders for SULT1C2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SULT1C2 gene, integrated from 10 sources (see all 34):
(articles sorted by number of sources associating them with SULT1C2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization. (PubMed id 10783263)1, 2, 3, 9 Freimuth R.R.... Weinshilboum R.M. (Genomics 2000)
  2. Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization. (PubMed id 9169148)1, 2, 3, 9 Her C.... Weinshilboum R.M. (Genomics 1997)
  3. Molecular characterization of ST1C1-related human sulfotransferase. (PubMed id 9635888)1, 2, 9 Yoshinari K.... Yamazoe Y. (Carcinogenesis 1998)
  4. Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). (PubMed id 16804942)1, 2, 9 Dombrovski L.... Plotnikov A.N. (Proteins 2006)
  5. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
  6. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
  7. Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia. (PubMed id 16507781)1, 4 Monzo M....Sierra J. (Blood 2006)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. Molecular cloning, expression, localisation and functional characterisation of a rabbit SULT1C2 sulfotransferase. (PubMed id 10481272)1, 2 Hehonah N....McManus M. (Int. J. Biochem. Cell Biol. 1999)
  10. Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2- acetylaminofluorene. (PubMed id 9852044)1, 2 Sakakibara Y.... Liu M.-C. (J. Biol. Chem. 1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6819 HGNC: 11456 AceView: SULT1C1 Ensembl:ENSG00000198203 euGenes: HUgn6819
ECgene: SULT1C2 H-InvDB: SULT1C2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SULT1C2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SULT1C2 gene:
Search GeneIP for patents involving SULT1C2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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