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Aliases for SULT1C2 Gene

Aliases for SULT1C2 Gene

  • Sulfotransferase Family, Cytosolic, 1C, Member 2 2 3
  • SULT1C1 3 4 6
  • Sulfotransferase Family, Cytosolic, 1C, Member 1 2 3
  • Sulfotransferase 1C1 3 4
  • HumSULTC2 3 4
  • SULT1C#1 3 4
  • ST1C2 3 4
  • Sulfotransferase 1C2 3
  • EC 2.8.2.1 64
  • EC 2.8.2.2 64
  • EC 2.8.2.- 4
  • EC 2.8.2 64
  • ST1C1 3

External Ids for SULT1C2 Gene

Previous Symbols for SULT1C2 Gene

  • SULT1C1

Summaries for SULT1C2 Gene

Entrez Gene Summary for SULT1C2 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1C2 Gene

SULT1C2 (Sulfotransferase Family, Cytosolic, 1C, Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Biological oxidations. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT1C2 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF)

Gene Wiki entry for SULT1C2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1C2 Gene

Genomics for SULT1C2 Gene

Genomic Location for SULT1C2 Gene

Start:
108,288,639 bp from pter
End:
108,309,915 bp from pter
Size:
21,277 bases
Orientation:
Plus strand

Genomic View for SULT1C2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SULT1C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1C2 Gene

Regulatory Elements for SULT1C2 Gene

Proteins for SULT1C2 Gene

  • Protein details for SULT1C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00338-ST1C2_HUMAN
    Recommended name:
    Sulfotransferase 1C2
    Protein Accession:
    O00338
    Secondary Accessions:
    • B2R813
    • Q53SG4

    Protein attributes for SULT1C2 Gene

    Size:
    296 amino acids
    Molecular mass:
    34880 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT1C2 Gene

    Alternative splice isoforms for SULT1C2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT1C2 Gene

Proteomics data for SULT1C2 Gene at MOPED

Post-translational modifications for SULT1C2 Gene

No Post-translational modifications

Other Protein References for SULT1C2 Gene

Domains for SULT1C2 Gene

Gene Families for SULT1C2 Gene

HGNC:
  • SULT :Sulfotransferases, cytosolic

Protein Domains for SULT1C2 Gene

UniProtKB/Swiss-Prot:

ST1C2_HUMAN
Family:
  • Belongs to the sulfotransferase 1 family.:
    • O00338
genes like me logo Genes that share domains with SULT1C2: view

Function for SULT1C2 Gene

Molecular function for SULT1C2 Gene

UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF)

Enzyme Numbers (IUBMB) for SULT1C2 Gene

Gene Ontology (GO) - Molecular Function for SULT1C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IDA 20056724
genes like me logo Genes that share ontologies with SULT1C2: view

miRNA for SULT1C2 Gene

miRTarBase miRNAs that target SULT1C2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SULT1C2 Gene

Localization for SULT1C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1C2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT1C2 Gene COMPARTMENTS Subcellular localization image for SULT1C2 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SULT1C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9169148
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SULT1C2: view

Pathways for SULT1C2 Gene

genes like me logo Genes that share pathways with SULT1C2: view

Pathways by source for SULT1C2 Gene

Interacting Proteins for SULT1C2 Gene

Gene Ontology (GO) - Biological Process for SULT1C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process --
GO:0009308 amine metabolic process TAS 9169148
GO:0044281 small molecule metabolic process TAS --
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
genes like me logo Genes that share ontologies with SULT1C2: view

Compounds for SULT1C2 Gene

(1) Novoseek inferred chemical compound relationships for SULT1C2 Gene

Compound -log(P) Hits PubMed IDs
n-hydroxy-2-acetylaminofluorene 86.7 1
genes like me logo Genes that share compounds with SULT1C2: view

Transcripts for SULT1C2 Gene

Unigene Clusters for SULT1C2 Gene

Sulfotransferase family, cytosolic, 1C, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1C2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - -

Relevant External Links for SULT1C2 Gene

GeneLoc Exon Structure for
SULT1C2
ECgene alternative splicing isoforms for
SULT1C2

Expression for SULT1C2 Gene

mRNA expression in normal human tissues for SULT1C2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT1C2 Gene

This gene is overexpressed in Kidney - Cortex (19.8), Stomach (17.8), and Thyroid (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SULT1C2 Gene

SOURCE GeneReport for Unigene cluster for SULT1C2 Gene Hs.436123

mRNA Expression by UniProt/SwissProt for SULT1C2 Gene

O00338-ST1C2_HUMAN
Tissue specificity: Found in adult stomach, kidney and thyroid gland, and in fetal kidney and liver
genes like me logo Genes that share expressions with SULT1C2: view

Orthologs for SULT1C2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1C2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT1C2 36
  • 99.46 (n)
  • 99.35 (a)
SULT1C2 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SULT1C2 36
  • 79.59 (n)
  • 75.51 (a)
SULT1C2 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SULT1C2 36
  • 85.96 (n)
  • 82.53 (a)
SULT1C2 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sult1c2 36
  • 82.21 (n)
  • 79.39 (a)
Sult1c2 16
Sult1c2 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 56 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SULT1C2 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sult1c1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1113 36
sult1b1 36
  • 58.68 (n)
  • 53.12 (a)
zebrafish
(Danio rerio)
Actinopterygii sult1st1 37
  • 41 (a)
ManyToMany
sult1st3 37
  • 41 (a)
ManyToMany
sult1st4 37
  • 40 (a)
ManyToMany
sult1st6 36
  • 58.59 (n)
  • 49.83 (a)
sult1st6 37
  • 44 (a)
ManyToMany
sult1st7 37
  • 41 (a)
ManyToMany
sult1st8 37
  • 41 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta St2 37
  • 29 (a)
OneToMany
CG6704 38
  • 32 (a)
CG5428 38
  • 34 (a)
CG16733 38
  • 29 (a)
Species with no ortholog for SULT1C2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT1C2 Gene

ENSEMBL:
Gene Tree for SULT1C2 (if available)
TreeFam:
Gene Tree for SULT1C2 (if available)

Paralogs for SULT1C2 Gene

Pseudogenes.org Pseudogenes for SULT1C2 Gene

genes like me logo Genes that share paralogs with SULT1C2: view

Variants for SULT1C2 Gene

Sequence variations from dbSNP and Humsavar for SULT1C2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs14700 -- 108,308,621(+) ACTTC(A/T)TTTTT utr-variant-3-prime
rs1047309 -- 108,308,728(+) TACAA(A/T)AGGAT utr-variant-3-prime, downstream-variant-500B
rs1047310 -- 108,309,293(+) GCCCT(C/G)TTGTT utr-variant-3-prime
rs1047311 -- 108,309,296(+) CTGTT(C/G)TTATG utr-variant-3-prime
rs1047312 -- 108,309,324(+) CTTAT(C/T)TATAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SULT1C2 Gene

Variant ID Type Subtype PubMed ID
esv2720498 CNV Deletion 23290073
dgv1233e1 CNV Complex 17122850
dgv1234e1 CNV Complex 17122850
dgv724e199 CNV Deletion 23128226
nsv874769 CNV Gain 21882294
nsv874770 CNV Loss 21882294
nsv527686 CNV Gain 19592680
dgv153e55 CNV Gain 17911159
nsv527491 CNV Loss 19592680
nsv874771 CNV Gain 21882294
nsv834327 CNV Gain 17160897
nsv10112 CNV Gain 18304495

Relevant External Links for SULT1C2 Gene

HapMap Linkage Disequilibrium report
SULT1C2
Human Gene Mutation Database (HGMD)
SULT1C2

Disorders for SULT1C2 Gene

Relevant External Links for SULT1C2

Genetic Association Database (GAD)
SULT1C2
Human Genome Epidemiology (HuGE) Navigator
SULT1C2
genes like me logo Genes that share disorders with SULT1C2: view

No data available for UniProtKB/Swiss-Prot for SULT1C2 Gene

Publications for SULT1C2 Gene

  1. Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization. (PMID: 9169148) Her C. … Weinshilboum R.M. (Genomics 1997) 2 3 4 23
  2. Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization. (PMID: 10783263) Freimuth R.R. … Weinshilboum R.M. (Genomics 2000) 2 3 4 23
  3. Molecular characterization of ST1C1-related human sulfotransferase. (PMID: 9635888) Yoshinari K. … Yamazoe Y. (Carcinogenesis 1998) 3 4 23
  4. Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). (PMID: 16804942) Dombrovski L. … Plotnikov A.N. (Proteins 2006) 3 4 23
  5. Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2- acetylaminofluorene. (PMID: 9852044) Sakakibara Y. … Liu M.-C. (J. Biol. Chem. 1998) 3 4

Products for SULT1C2 Gene

Sources for SULT1C2 Gene

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