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Aliases for SULT1B1 Gene

Aliases for SULT1B1 Gene

  • Sulfotransferase Family, Cytosolic, 1B, Member 1 2 3
  • ST1B2 3 4 6
  • Thyroid Hormone Sulfotransferase 3 4
  • Sulfotransferase 1B1 3 4
  • Sulfotransferase 1B2 3 4
  • SULT1B2 3 4
  • ST1B1 3 4
  • Sulfotransferase Family Cytosolic 1B Member 1 3
  • EC 2.8.2.1 63
  • EC 2.8.2.4 63
  • EC 2.8.2.- 4
  • EC 2.8.2 63

External Ids for SULT1B1 Gene

Previous GeneCards Identifiers for SULT1B1 Gene

  • GC04M070507
  • GC04M070641
  • GC04M070842
  • GC04M070909
  • GC04M070910
  • GC04M070773
  • GC04M066390
  • GC04M070586

Summaries for SULT1B1 Gene

Entrez Gene Summary for SULT1B1 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1B1 Gene

SULT1B1 (Sulfotransferase Family, Cytosolic, 1B, Member 1) is a Protein Coding gene. Among its related pathways are Metabolism and Biological oxidations. GO annotations related to this gene include sulfotransferase activity and aryl sulfotransferase activity. An important paralog of this gene is SULT1C3.

UniProtKB/Swiss-Prot for SULT1B1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.

Gene Wiki entry for SULT1B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1B1 Gene

Genomics for SULT1B1 Gene

Regulatory Elements for SULT1B1 Gene

Genomic Location for SULT1B1 Gene

Start:
69,721,162 bp from pter
End:
69,787,961 bp from pter
Size:
66,800 bases
Orientation:
Minus strand

Genomic View for SULT1B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SULT1B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1B1 Gene

Proteins for SULT1B1 Gene

  • Protein details for SULT1B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43704-ST1B1_HUMAN
    Recommended name:
    Sulfotransferase family cytosolic 1B member 1
    Protein Accession:
    O43704
    Secondary Accessions:
    • O15497
    • Q96FI1
    • Q9UK34

    Protein attributes for SULT1B1 Gene

    Size:
    296 amino acids
    Molecular mass:
    34899 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for SULT1B1 Gene

neXtProt entry for SULT1B1 Gene

Proteomics data for SULT1B1 Gene at MOPED

Selected DME Specific Peptides for SULT1B1 Gene

Post-translational modifications for SULT1B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT1B1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SULT1B1 Gene

Gene Families for SULT1B1 Gene

HGNC:
  • SULT :Sulfotransferases, cytosolic

Protein Domains for SULT1B1 Gene

Suggested Antigen Peptide Sequences for SULT1B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43704

UniProtKB/Swiss-Prot:

ST1B1_HUMAN :
  • O43704
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1B1: view

Function for SULT1B1 Gene

Molecular function for SULT1B1 Gene

UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.

Enzyme Numbers (IUBMB) for SULT1B1 Gene

Gene Ontology (GO) - Molecular Function for SULT1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008146 sulfotransferase activity IDA 20056724
genes like me logo Genes that share ontologies with SULT1B1: view

Phenotypes for SULT1B1 Gene

GenomeRNAi human phenotypes for SULT1B1:
genes like me logo Genes that share phenotypes with SULT1B1: view

miRNA for SULT1B1 Gene

miRTarBase miRNAs that target SULT1B1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SULT1B1 Gene

Localization for SULT1B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1B1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT1B1 Gene COMPARTMENTS Subcellular localization image for SULT1B1 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SULT1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT1B1: view

Pathways for SULT1B1 Gene

genes like me logo Genes that share pathways with SULT1B1: view

Pathways by source for SULT1B1 Gene

Gene Ontology (GO) - Biological Process for SULT1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006576 cellular biogenic amine metabolic process TAS 9443824
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process --
GO:0008202 steroid metabolic process IEA --
GO:0009812 flavonoid metabolic process IDA 20056724
genes like me logo Genes that share ontologies with SULT1B1: view

Compounds for SULT1B1 Gene

(1) Drugbank Compounds for SULT1B1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine-3'-5'-Diphosphate
target

(3) Novoseek inferred chemical compound relationships for SULT1B1 Gene

Compound -log(P) Hits PubMed IDs
p-nitrophenol 79.2 1
phenol 63.3 1
estrogen 14.7 1
genes like me logo Genes that share compounds with SULT1B1: view

Transcripts for SULT1B1 Gene

mRNA/cDNA for SULT1B1 Gene

(3) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT1B1 Gene

Sulfotransferase family, cytosolic, 1B, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1B1 Gene

No ASD Table

Relevant External Links for SULT1B1 Gene

GeneLoc Exon Structure for
SULT1B1
ECgene alternative splicing isoforms for
SULT1B1

Expression for SULT1B1 Gene

mRNA expression in normal human tissues for SULT1B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT1B1 Gene

This gene is overexpressed in Whole Blood (19.7), Colon - Transverse (9.4), and Liver (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SULT1B1 Gene

SOURCE GeneReport for Unigene cluster for SULT1B1 Gene Hs.129742

mRNA Expression by UniProt/SwissProt for SULT1B1 Gene

O43704-ST1B1_HUMAN
Tissue specificity: Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus.
genes like me logo Genes that share expressions with SULT1B1: view

Orthologs for SULT1B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT1B1 35
  • 99.1 (n)
  • 98.31 (a)
SULT1B1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SULT1B1 35
  • 86.82 (n)
  • 83.11 (a)
SULT1B1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SULT1B1 35
  • 87.05 (n)
  • 84.12 (a)
SULT1B1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sult1b1 35
  • 80.29 (n)
  • 72.3 (a)
Sult1b1 16
Sult1b1 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SULT1B1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sult1b1 35
  • 79.28 (n)
  • 73.65 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 59 (a)
OneToMany
SULT1B1 35
  • 62.28 (n)
  • 61.25 (a)
SULT1B1 36
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SULT1B1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC779590 35
  • 63.74 (n)
  • 59.3 (a)
Str.12317 35
zebrafish
(Danio rerio)
Actinopterygii sult1st2 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010987 35
  • 45.51 (n)
  • 34.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta St1 35
  • 44.89 (n)
  • 32.26 (a)
CG6704 37
  • 31 (a)
CG5428 37
  • 33 (a)
CG16733 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea ssu-1 35
  • 51.42 (n)
  • 35.9 (a)
Y113G7A.11 37
  • 32 (a)
Species with no ortholog for SULT1B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SULT1B1 Gene

ENSEMBL:
Gene Tree for SULT1B1 (if available)
TreeFam:
Gene Tree for SULT1B1 (if available)

Paralogs for SULT1B1 Gene

Selected SIMAP similar genes for SULT1B1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SULT1B1 Gene

genes like me logo Genes that share paralogs with SULT1B1: view

Variants for SULT1B1 Gene

Sequence variations from dbSNP and Humsavar for SULT1B1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1354360 -- 69,750,604(-) TTCAA(C/T)GAGTG intron-variant
rs1394032 -- 69,753,320(+) AACAA(C/G)TCACA intron-variant
rs1394033 -- 69,753,324(+) AGTCA(A/C)AAATA intron-variant
rs1394037 -- 69,733,678(-) AAATA(C/T)CTGAT intron-variant
rs1394038 -- 69,733,668(-) TGTTT(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULT1B1 Gene

Variant ID Type Subtype PubMed ID
dgv5626n71 CNV Loss 21882294

Relevant External Links for SULT1B1 Gene

HapMap Linkage Disequilibrium report
SULT1B1
Human Gene Mutation Database (HGMD)
SULT1B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1B1 Gene

Disorders for SULT1B1 Gene

Relevant External Links for SULT1B1

Genetic Association Database (GAD)
SULT1B1
Human Genome Epidemiology (HuGE) Navigator
SULT1B1
genes like me logo Genes that share disorders with SULT1B1: view

No data available for UniProtKB/Swiss-Prot for SULT1B1 Gene

Publications for SULT1B1 Gene

  1. Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases. (PMID: 9443824) Fujita K. … Yamazoe Y. (J. Biochem. 1997) 2 3 4 23
  2. Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene. (PMID: 11688987) Meinl W. … Glatt H. (Biochem. Biophys. Res. Commun. 2001) 2 3 23
  3. Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver. (PMID: 9463486) Wang J. … Falany C.N. (Mol. Pharmacol. 1998) 3 4
  4. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 48
  5. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross C.J. … Hayden M.R. (Nat. Genet. 2009) 3 48

Products for SULT1B1 Gene

Sources for SULT1B1 Gene

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