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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SULT1B1 Gene

protein-coding   GIFtS: 61
GCID: GC04M070641

sulfotransferase family, cytosolic, 1B, member 1

 Explore 7 diseases affiliated with
SULT1B1 via our new
 Human Malady Compendium 
Biological research products
for SULT1B1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Sulfotransferase Family, Cytosolic, 1B, Member 11 2     SULT1B22 3
ST1B21 2 3     Sulfotransferase Family Cytosolic 1B Member 12
Sulfotransferase 1B12 3     EC 2.8.2.-3
Sulfotransferase 1B22 3     EC 2.8.28
Thyroid Hormone Sulfotransferase2 3     EC 2.8.2.18
ST1B12 3     EC 2.8.2.48

External Ids:    HGNC: 178451   Entrez Gene: 272842   Ensembl: ENSG000001735977   OMIM: 6084365   UniProtKB: O437043   

Export aliases for SULT1B1 gene to outside databases

Previous GC identifers: GC04M070507 GC04M070842 GC04M070909 GC04M070910 GC04M070773 GC04M066390


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SULT1B1:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic
compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene
structure (number and length of exons) is similar among family members. However, the total genomic length of this gene
is greater than that of other SULT1 genes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ST1B1_HUMAN, O43704
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the
water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to
form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones,
including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine

Gene Wiki entry for SULT1B1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SULT1B1 gene promoter:
         c-Fos   USF1   AP-1   Meis-1b   Evi-1   AREB6   POU2F1   POU2F1a   USF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSULT1B1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SULT1B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULT1B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

SULT1B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT1B1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M070641:  view genomic region     (about GC identifiers)

Start:
70,592,566 bp from pter      End:
70,653,679 bp from pter
Size:
61,114 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ST1B1_HUMAN, O43704 (See protein sequence)
Recommended Name: Sulfotransferase family cytosolic 1B member 1  
Size: 296 amino acids; 34899 Da
Subunit: Monomer (By similarity)
Subcellular location: Cytoplasm (By similarity)
2 PDB 3D structures from and Proteopedia for SULT1B1:
2Z5F (3D)        3CKL (3D)    
Secondary accessions: O15497 Q96FI1 Q9UK34

Explore the universe of human proteins at neXtProt for SULT1B1: NX_O43704

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43704

  • 4/7 DME Specific Peptides for SULT1B1 (O43704) (see all 7)
     SPFMRKG  PKSGTTW  FTVAQNE  GDWKNYFT 

    SULT1B1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055280.2  
    ENSEMBL proteins: 
     ENSP00000308770   ENSP00000425464   ENSP00000427536  
    Reactome Protein details: O43704
    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for SULT1B1
    Uscn Proteins for SULT1B1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    SULT1B1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SULT1B1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry O43704

    ProtoNet protein and cluster: O43704

    1 Blocks protein family: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST1B1_HUMAN, O43704
    Similarity: Belongs to the sulfotransferase 1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ST1B1_HUMAN, O43704
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the
    water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to
    form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones,
    including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine

    Enzyme Numbers (IUBMB): EC 2.8.2.-1 EC 2.8.2.42 EC 2.8.22 EC 2.8.2.12

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004062aryl sulfotransferase activity IEA--
    GO:0008146sulfotransferase activity IDA--


    SULT1B1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SULT1B1:
     Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Biological oxidations
    Biological oxidations1.00
    metapathway biotransformation0.41
    Phase II conjugation0.52
    2Cytosolic sulfonation of small molecules
    Cytosolic sulfonation of small molecules1.00
    Sulfation Biotransformation Reaction0.67
    3Metabolism
    Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for SULT1B1 
        Sulfation Biotransformation Reaction
    metapathway biotransformation

    4        Reactome Pathways for SULT1B1
        Metabolism
    Biological oxidations
    Cytosolic sulfonation of small molecules
    Phase II conjugation



    SULT1B1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SULT1B1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SULT1B1 (ENSP000003087704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POT1ENSP000003502494STRING: ENSP00000350249
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006576cellular biogenic amine metabolic process TAS9443824
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008202steroid metabolic process IEA--
    GO:0009812flavonoid metabolic process IDA--
    GO:0018958phenol-containing compound metabolic process IDA9463486


    SULT1B1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SULT1B1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SULT1B1

    1 DrugBank Compound for SULT1B1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-3'-5'-Diphosphate-- --target----

    3 Novoseek chemical compound relationships for SULT1B1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    p-nitrophenol 79.2 1 16413005 (1)
    phenol 63.3 2 9644246 (1)
    estrogen 14.7 2 9644246 (1)

    Search CenterWatch for drugs/clinical trials and news about SULT1B1 / ST1B1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SULT1B1 gene: 
    NM_014465.3  

    Unigene Cluster for SULT1B1:

    Sulfotransferase family, cytosolic, 1B, member 1
    Hs.129742  [show with all ESTs]
    Unigene Representative Sequence: BC010895
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310613(uc003hen.3) ENST00000510821 ENST00000512870

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    Additional cDNA sequence: 

    BC010895.1 D89479.1 U95726.1 

    1 DOTS entry:

    DT.402685 

    8 AceView cDNA sequences:

    BX281432 U95726 NM_014465 BE463423 D89479 BC010895 BG461453 BF241490 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SULT1B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAAAAACTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SULT1B1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium
    CD31, CD144 positive cells (Two-step protocol fo...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SULT1B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SULT1B1

    SOURCE GeneReport for Unigene cluster: Hs.129742

    UniProtKB/Swiss-Prot: ST1B1_HUMAN, O43704
    Tissue specificity: Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine
    (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus

        SABiosciences Expression via Pathway-Focused PCR Array including SULT1B1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SULT1B1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SULT1B1 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SULT1B11 sulfotransferase family, cytosolic, 1B, member 1 62.28(n)
    61.25(a)
      395227  NM_204545.1  NP_989876.1 
    lizard
    (Anolis carolinensis)
    Reptilia SULT1B16
    --
    53(a)
    1 ↔ 1
    6(58696591-58711618)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.123172 Transcribed sequence with weak similarity to protein more 72.95(n)    BX706612.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sult1st22 sulfotransferase family 1, cytosolic sulfotransferase more 74.33(n)   368269  AY181065.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG54283 sulfotransferase 33(a)
    (best of 3)
      59F6   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y113G7A.113
    ssu-11
    Protein SSU-11 32(a)3
    51(n)1
    35.04(a)1
      V(20120519-20125245)3
    1909591  NM_075479.11  NP_507880.11 


    ENSEMBL Gene Tree for SULT1B1 (if available)
    TreeFam Gene Tree for SULT1B1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SULT1B1 gene
    SULT1C32  SULT4A12  SULT1C42  SULT1A22  SULT1C22  SULT2B12  SULT1E12  SULT1A42  
    SULT2A12  SULT6B12  SULT1A12  SULT1A32  
    13 SIMAP similar genes for SULT1B1 using alignment to 3 protein entries:     ST1B1_HUMAN (see all proteins):
    SULT1C2    SULT1A3    SULT1E1    ST1A5    SULT1A4    SULT1A2
    SULT1C3    SULT1C4    SULT1A1    SULT2A1    SULT2B1    SULT4A1
    SULT6B1

    SULT1B1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SULT1B1
    PGOHUM00000250718


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SULT1B1
         2 CNVs: 80363 80362
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SULT1B1
    DNA2.0 Custom Variant and Variant Library Synthesis for SULT1B1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SULT1B1 for disorders           About GeneDecksing

    OMIM gene information: 608436    OMIM disorders: --

    7 diseases for SULT1B1:    About MalaCards
    thyroiditis    thyroid hormone metabolism    hearing loss    endometritis
    hepatitis    neuronitis    alcoholism

    Human Genome Epidemiology (HuGE) Navigator: SULT1B1 (3 documents)

    Export disorders for SULT1B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SULT1B1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with SULT1B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases. (PubMed id 9443824)1, 2, 3, 9 Fujita K....Yamazoe Y. (1997)
    2. Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene. (PubMed id 11688987)1, 3, 9 Meinl W. and Glatt H. (2001)
    3. Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). (PubMed id 16804942)1, 2 Dombrovski L....Plotnikov A.N. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver. (PubMed id 9463486)1, 2 Wang J.... Falany C.N. (1998)
    6. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    7. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1 Saito A....Kamatani N. (2009)
    8. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1 Ross C.J....Hayden M.R. (2009)
    9. Structural and chemical profiling of the human cytosolic sulfotransferases. (PubMed id 17425406)1 Allali-Hassani A....Arrowsmith C.H. (2007)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27284 HGNC: 17845 AceView: SULT1B1 Ensembl:ENSG00000173597 euGenes: HUgn27284
    ECgene: SULT1B1 H-InvDB: SULT1B1

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for SULT1B1 Pharmacogenomics, SNPs, Pathways

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