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Aliases for SULT1A4 Gene

Aliases for SULT1A4 Gene

  • Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 4 2 3
  • Aryl Sulfotransferase 1A3/1A4 3 4
  • ST1A4 3 4
  • Catecholamine-Sulfating Phenol Sulfotransferase 3
  • Monoamine-Sulfating Phenol Sulfotransferase 3
  • Sulfotransferase, Monoamine-Preferring 3
  • Thermolabile Phenol Sulfotransferase 3
  • Placental Estrogen Sulfotransferase 3
  • Sulfotransferase 1A3/1A4 4
  • Sulfotransferase 1A4 3
  • SLX1B-SULT1A4 3
  • ST1A3/ST1A4 3
  • Sulfokinase 3
  • EC 2.8.2.1 4
  • TL-PST 3
  • HAST3 3
  • M-PST 3

External Ids for SULT1A4 Gene

Previous GeneCards Identifiers for SULT1A4 Gene

  • GC16U900494
  • GC16P029375
  • GC16P029378
  • GC16P029466
  • GC16P029479
  • GC16P029484

Summaries for SULT1A4 Gene

Entrez Gene Summary for SULT1A4 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]

GeneCards Summary for SULT1A4 Gene

SULT1A4 (Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 4) is a Protein Coding gene. Among its related pathways are Metabolism and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include sulfotransferase activity and aryl sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT1A4 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1A4 Gene

Genomics for SULT1A4 Gene

Regulatory Elements for SULT1A4 Gene

Genomic Location for SULT1A4 Gene

Start:
29,459,886 bp from pter
End:
29,464,980 bp from pter
Size:
5,095 bases
Orientation:
Plus strand

Genomic View for SULT1A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SULT1A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1A4 Gene

Proteins for SULT1A4 Gene

  • Protein details for SULT1A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMN0-ST1A4_HUMAN
    Recommended name:
    Sulfotransferase 1A4
    Protein Accession:
    P0DMN0
    Secondary Accessions:
    • B4DNV0
    • O95603
    • P50224
    • Q1ET66
    • Q6ZWJ5

    Protein attributes for SULT1A4 Gene

    Size:
    295 amino acids
    Molecular mass:
    34196 Da
    Quaternary structure:
    • Homodimer

neXtProt entry for SULT1A4 Gene

Proteomics data for SULT1A4 Gene at MOPED

Post-translational modifications for SULT1A4 Gene

Other Protein References for SULT1A4 Gene

Antibody Products

No data available for DME Specific Peptides for SULT1A4 Gene

Domains for SULT1A4 Gene

Gene Families for SULT1A4 Gene

HGNC:
  • SULT :Sulfotransferases, cytosolic

Protein Domains for SULT1A4 Gene

Suggested Antigen Peptide Sequences for SULT1A4 Gene

Graphical View of Domain Structure for InterPro Entry

P0DMN0

UniProtKB/Swiss-Prot:

ST1A4_HUMAN :
  • P0DMN0
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1A4: view

Function for SULT1A4 Gene

Molecular function for SULT1A4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + a phenol = adenosine 3,5-bisphosphate + an aryl sulfate
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs

Enzyme Numbers (IUBMB) for SULT1A4 Gene

Gene Ontology (GO) - Molecular Function for SULT1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity IEA --
GO:0008146 sulfotransferase activity --
genes like me logo Genes that share ontologies with SULT1A4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SULT1A4

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SULT1A4 Gene

Localization for SULT1A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1A4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT1A4 Gene COMPARTMENTS Subcellular localization image for SULT1A4 gene
Compartment Confidence
cytosol 4
nucleus 1

Gene Ontology (GO) - Cellular Components for SULT1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SULT1A4: view

Pathways for SULT1A4 Gene

genes like me logo Genes that share pathways with SULT1A4: view

Interacting Proteins for SULT1A4 Gene

Gene Ontology (GO) - Biological Process for SULT1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006584 catecholamine metabolic process IEA --
GO:0008152 metabolic process --
GO:0008202 steroid metabolic process IEA --
genes like me logo Genes that share ontologies with SULT1A4: view

Transcripts for SULT1A4 Gene

mRNA/cDNA for SULT1A4 Gene

(2) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT1A4 Gene

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SULT1A4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1A4 Gene

No ASD Table

Relevant External Links for SULT1A4 Gene

GeneLoc Exon Structure for
SULT1A4
ECgene alternative splicing isoforms for
SULT1A4

Expression for SULT1A4 Gene

mRNA expression in normal human tissues for SULT1A4 Gene

Protein differential expression in normal tissues for SULT1A4 Gene

This gene is overexpressed in Heart (44.0) and Skin (24.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SULT1A4 Gene

SOURCE GeneReport for Unigene cluster for SULT1A4 Gene Hs.744871

mRNA Expression by UniProt/SwissProt for SULT1A4 Gene

P0DMN0-ST1A4_HUMAN
Tissue specificity: Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte
genes like me logo Genes that share expressions with SULT1A4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SULT1A4 Gene

Orthologs for SULT1A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SULT1A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC454364 35
  • 99.32 (n)
  • 98.31 (a)
-- 36
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SULT1A1 36
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SULT1A1 36
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sult1a1 36
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
Species with no ortholog for SULT1A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SULT1A4 Gene

ENSEMBL:
Gene Tree for SULT1A4 (if available)
TreeFam:
Gene Tree for SULT1A4 (if available)

Paralogs for SULT1A4 Gene

Selected SIMAP similar genes for SULT1A4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SULT1A4: view

Variants for SULT1A4 Gene

Structural Variations from Database of Genomic Variants (DGV) for SULT1A4 Gene

Variant ID Type Subtype PubMed ID
dgv845e1 CNV Complex 17122850
nsv905711 CNV Gain 21882294
esv29892 CNV Gain 19812545
esv2714183 CNV Deletion 23290073
nsv498862 CNV Loss 21111241
nsv820959 CNV Duplication 20802225
nsv9426 CNV Gain 18304495
dgv846e1 CNV Complex 17122850
dgv847e1 CNV Complex 17122850
nsv9431 CNV Gain+Loss 18304495
esv22245 CNV Gain 19812545
nsv821543 CNV Duplication 20802225
nsv471389 CNV Duplication 19718026

Relevant External Links for SULT1A4 Gene

HapMap Linkage Disequilibrium report
SULT1A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SULT1A4 Gene

Disorders for SULT1A4 Gene

(1) University of Copenhagen DISEASES for SULT1A4 Gene

genes like me logo Genes that share disorders with SULT1A4: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for SULT1A4 Gene

Publications for SULT1A4 Gene

  1. Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies. (PMID: 15358107) Hildebrandt M.A.T. … Weinshilboum R.M. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. Phylogenomic approaches to common problems encountered in the analysis of low copy repeats: the sulfotransferase 1A gene family example. (PMID: 15752422) Bradley M.E. … Benner S.A. (BMC Evol. Biol. 2005) 2 3
  3. Structural and chemical profiling of the human cytosolic sulfotransferases. (PMID: 17425406) Allali-Hassani A. … Arrowsmith C.H. (PLoS Biol. 2007) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism. (PMID: 14622112) Thomae B.A. … Weinshilboum R.M. (J. Neurochem. 2003) 4

Products for SULT1A4 Gene

Sources for SULT1A4 Gene

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