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SULT1A4 Gene

protein-coding   GIFtS: 42
GCID: GC16P029484

Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring,...

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 41 2     ST1A3/ST1A42 3
Aryl Sulfotransferase 1A3/1A42 3     TL-PST2 3
Catecholamine-Sulfating Phenol Sulfotransferase2 3     EC 2.8.2.13 8
Monoamine-Sulfating Phenol Sulfotransferase2 3     SLX1B-SULT1A42
Placental Estrogen Sulfotransferase2 3     sulfokinase2
Sulfotransferase, Monoamine-Preferring2 3     Sulfotransferase 1A3/1A42
Thermolabile Phenol Sulfotransferase2 3     STM3
HAST32 3     EC 2.8.28
M-PST2 3     

External Ids:    HGNC: 300041   Entrez Gene: 4453292   Ensembl: ENSG000002136487   UniProtKB: P502243   

Export aliases for SULT1A4 gene to outside databases

Previous GC identifers: GC16U900494 GC16P029375 GC16P029378 GC16P029466 GC16P029479


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SULT1A4 Gene:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and
xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate
specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes
a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm
of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists
between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that
encodes a protein containing GIY-YIG domains. (provided by RefSeq, Nov 2010)

GeneCards Summary for SULT1A4 Gene:
SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) is a protein-coding gene. Diseases associated with SULT1A4 include batten disease. GO annotations related to this gene include sulfotransferase activity and aryl sulfotransferase activity. An important paralog of this gene is SULT1C3.

UniProtKB/Swiss-Prot: ST1A3_HUMAN, P50224
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and
phenolic and catechol drugs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SULT1A4 gene promoter:
         E2F-4   E2F-3a   E2F   E2F-1   SRF (504 AA)   E2F-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SULT1A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SULT1A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SULT1A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT1A4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029484:  view genomic region     (about GC identifiers)

Start:
29,467,127 bp from pter      End:
29,476,301 bp from pter
Size:
9,175 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for SULT1A4

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ST1A3_HUMAN, P50224 (See protein sequence)
Recommended Name: Sulfotransferase 1A3/1A4  
Size: 295 amino acids; 34196 Da
Subunit: Homodimer
2 PDB 3D structures from and Proteopedia for SULT1A4:
1CJM (3D)        2A3R (3D)    
Secondary accessions: B4DNV0 O95603 Q1ET66 Q6ZWJ5
Alternative splicing: 3 isoforms:  P50224-1   P50224-2   P50224-3   (No experimental confirmation available. Ref.10 (BAC85507) sequence differs from that shown due to a frameshift in position 101)

Explore the universe of human proteins at neXtProt for SULT1A4: NX_P50224

Explore proteomics data for SULT1A4 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SULT1A4 (P50224) (see all 11)
     LYLFYED  FTVAQNE  SPFMRKG  FQARPDD 


    See SULT1A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001017390.1  
    ENSEMBL proteins: 
     ENSP00000353600   ENSP00000455063   ENSP00000456834   ENSP00000457597   ENSP00000339221  
     ENSP00000378796  
    Reactome Protein details: P50224

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULT: Sulfotransferases, cytosolic

    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry P50224

    ProtoNet protein and cluster: P50224

    1 Blocks protein domain: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST1A3_HUMAN, P50224
    Similarity: Belongs to the sulfotransferase 1 family


    SULT1A4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST1A3_HUMAN, P50224
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and
    phenolic and catechol drugs
    Catalytic activity: 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate

         Enzyme Numbers (IUBMB): EC 2.8.2.11 2 EC 2.8.22

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004062aryl sulfotransferase activity TAS--
    GO:0008146sulfotransferase activity IDA--
         
    SULT1A4 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ST1A3_HUMAN, P50224: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8363592
    GO:0005829cytosol TAS--

    SULT1A4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SULT1A4 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Cytosolic sulfonation of small molecules0.00
    Phase II conjugation0.56
    Estradiol metabolism0.00
    metapathway biotransformation0.42
    2tryptophan utilization II
    tryptophan utilization II0.71
    serotonin degradation0.00
    tryptophan utilization I0.71
    3Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    4Chemical carcinogenesis
    Chemical carcinogenesis0.71
    5Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for SULT1A4
        Estradiol metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism

    Selected BioSystems Pathways for SULT1A4 (see all 6)
        Sulfation Biotransformation Reaction
    dopamine degradation
    serotonin degradation
    metapathway biotransformation
    tryptophan utilization II

    2 Reactome Pathways for SULT1A4
        XBP1(S) activates chaperone genes
    Cytosolic sulfonation of small molecules

    1 PharmGKB Pathway for SULT1A4
        Acetaminophen Pathway, Pharmacokinetics

    1 Kegg Pathway  (Kegg details for SULT1A4):
        Chemical carcinogenesis


    SULT1A4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SULT1A4
    Interactions:

        Search GeneGlobe Interaction Network for SULT1A4

    3 Interacting proteins for SULT1A4 (P502242, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271553 I2D: score=2 
    SMN2Q166372, 3MINT-8271553 I2D: score=2 
    TK1P041832, 3MINT-8274137 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006584catecholamine metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0008202steroid metabolic process IEA--
    GO:0009812flavonoid metabolic process IDA--

    SULT1A4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SULT1A4 (ST1A3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SULT1A4 gene (3 alternative transcripts): 
    NM_001017390.2  NM_001017389.1  NM_001017391.1  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360423(uc010vdp.2 uc002dtb.3) ENST00000569544 ENST00000565290
    ENST00000563944 ENST00000562941 ENST00000344620(uc010byw.3) ENST00000395400(uc002dta.3)

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      QuantiTect SYBR Green Assays in human, mouse, rat SULT1A4
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SULT1A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SULT1A4 Expression
    About this image

    SULT1A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SULT1A4 Protein Expression

    UniProtKB/Swiss-Prot: ST1A3_HUMAN, P50224
    Tissue specificity: Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SULT1A4 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    58(a)
    57(a)
    many ↔ many
    many ↔ many
    GL343287.1(1045659-1052531)
    GL343287.1(1028874-1041016)
            Species with no ortholog for SULT1A4

    ENSEMBL Gene Tree for SULT1A4 (if available)
    TreeFam Gene Tree for SULT1A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SULT1A4 gene
    SULT1A31 2  SULT1C32  SULT4A12  SULT1B12  SULT1A22  SULT1C42  SULT1C22  SULT1E12  
    SULT2B12  SULT2A12  SULT6B12  SULT1A12  
    14 SIMAP similar genes for SULT1A4 using alignment to 3 protein entries:     ST1A3_HUMAN (see all proteins):
    STP1    SULT1A3    ST1A5    SULT1A1    SULT1A2    SULT1E1
    SULT1B1    SULT1C3    SULT1C2    SULT2A1    SULT1C4    SULT2B1
    SULT4A1    SULT6B1

    SULT1A4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SULT1A4 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714183CNV Deletion23290073
    nsv821543CNV Duplication20802225
    nsv471389CNV Duplication19718026
    nsv820959CNV Duplication20802225
    nsv498862CNV Loss21111241
    nsv9426CNV Gain18304495
    esv29892CNV Gain19812545
    nsv905711CNV Gain21882294
    esv22245CNV Gain19812545
    nsv9431CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for SULT1A4:    
    About MalaCards
    batten disease

    1 disease from the University of Copenhagen DISEASES database for SULT1A4:
    Batten disease

    SULT1A4 for disorders           About GeneDecksing


    Export disorders for SULT1A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SULT1A4 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with SULT1A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phylogenomic approaches to common problems encountered in the analysis of low copy repeats: the sulfotransferase 1A gene family example. (PubMed id 15752422)1, 3 Bradley M.E. and Benner S.A. (BMC Evol. Biol. 2005)
    2. Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies. (PubMed id 15358107)1, 3 Hildebrandt M.A.T.... Weinshilboum R.M. (Biochem. Biophys. Res. Commun. 2004)
    3. Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene. (PubMed id 7961757)1, 2 Bernier F.... Luu-The V. (J. Biol. Chem. 1994)
    4. Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization. (PubMed id 8117269)1, 2 Wood T.C.... Weinshilboum R.M. (Biochem. Biophys. Res. Commun. 1994)
    5. Identification of two human brain aryl sulfotransferase cDNAs. (PubMed id 8363592)1, 2 Zhu X.... McManus M.E. (Biochem. Biophys. Res. Commun. 1993)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Structural and chemical profiling of the human cytosolic sulfotransferases. (PubMed id 17425406)1 Allali-Hassani A.... Arrowsmith C.H. (PLoS Biol. 2007)
    9. Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. (PubMed id 16083857)2 Lu J.H.... Chang W.R. (Biochem. Biophys. Res. Commun. 2005)
    10. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 445329 HGNC: 30004 Ensembl:ENSG00000213648 euGenes: HUgn445329 ECgene: SULT1A4 Kegg: 445329
    H-InvDB: SULT1A4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SULT1A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for SULT1A4 gene:
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    GeneCards and IP:
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