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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SULT1A3 Gene

protein-coding   GIFtS: 62
GCID: GC16P030213

Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring,...


(Previous symbol: STM)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 31 2     ST1A52
STM1 2 3 5     Dopamine-Specific Sulfotransferase2
Aryl Sulfotransferase 1A3/1A42 3     Monoamine-Sulfating Phenosulfotransferase2
Catecholamine-Sulfating Phenol Sulfotransferase2 3     Phenol Sulfotransferase 1A52
Placental Estrogen Sulfotransferase2 3     sulfokinase2
HAST32 3     Sulfotransferase 1A3/1A42
M-PST2 3     Thermolabile (Monoamine, M Form) Phenol Sulfotransferase2
ST1A3/ST1A42 3     Monoamine-Sulfating Phenol Sulfotransferase3
TL-PST2 3     Sulfotransferase, Monoamine-Preferring3
EC 2.8.2.13 8     Thermolabile Phenol Sulfotransferase3
HAST2     EC 2.8.28

External Ids:    HGNC: 114551   Entrez Gene: 68182   Ensembl: ENSG000002610527   OMIM: 6006415   UniProtKB: P502243   

Export aliases for SULT1A3 gene to outside databases

Previous GC identifers: GC16M029624 GC16P030599 GC16P030203 GC16P030241 GC16P030112 GC16P030206 GC16P027869 GC16P030209


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SULT1A3 Gene:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and
xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate
specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes
a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm
of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of
the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1
structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains.
(provided by RefSeq, Nov 2010)

GeneCards Summary for SULT1A3 Gene: 
SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) is a protein-coding gene. Diseases associated with SULT1A3 include rheumatoid arthritis, association with, and cerebral infarction, and among its related super-pathways are Acetaminophen metabolism and tryptophan utilization I. An important paralog of this gene is SULT1C3.

UniProtKB/Swiss-Prot: ST1A3_HUMAN, P50224
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and
phenolic and catechol drugs

Gene Wiki entry for SULT1A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SULT1A3 gene promoter:
         CREB   deltaCREB   p300   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): SULT1A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SULT1A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULT1A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SULT1A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT1A3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P030213:  view genomic region     (about GC identifiers)

Start:
30,205,754 bp from pter      End:
30,215,650 bp from pter
Size:
9,897 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ST1A3_HUMAN, P50224 (See protein sequence)
Recommended Name: Sulfotransferase 1A3/1A4  
Size: 295 amino acids; 34196 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
2 PDB 3D structures from and Proteopedia for SULT1A3:
1CJM (3D)        2A3R (3D)    
Secondary accessions: B4DNV0 O95603 Q6ZWJ5
Alternative splicing: 2 isoforms:  P50224-1   P50224-2   (No experimental confirmation available. Ref.9 (BAC85507) sequence differs from that shown due to a frameshift in position 101)

Explore the universe of human proteins at neXtProt for SULT1A3: NX_P50224

Explore proteomics data for SULT1A3 at MOPED 

Post-translational modifications:

  • UniProtKB: The N-terminus is blocked
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50224

  • 4/11 DME Specific Peptides for SULT1A3 (P50224) (see all 11)
     LYLFYED  FTVAQNE  SPFMRKG  FQARPDD 

    SULT1A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SULT1A3 Protein Expression
    REFSEQ proteins: NP_808220.1  
    ENSEMBL proteins: 
     ENSP00000343645   ENSP00000378570   ENSP00000454518   ENSP00000455372   ENSP00000456391  
     ENSP00000346760   ENSP00000347739   ENSP00000378569  
    Reactome Protein details: P50224
    Human Recombinant Protein Products for SULT1A3: 
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    Cloud-Clone Corp. Proteins for SULT1A3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol ----

    SULT1A3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SULT: Sulfotransferases, cytosolic

    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry P50224

    ProtoNet protein and cluster: P50224

    1 Blocks protein domain: IPB000863 Sulfotransferase

    UniProtKB/Swiss-Prot: ST1A3_HUMAN, P50224
    Similarity: Belongs to the sulfotransferase 1 family


    SULT1A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST1A3_HUMAN, P50224
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the
    sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and
    phenolic and catechol drugs
    Catalytic activity: 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate

         Genatlas biochemistry entry for SULT1A3:
    aryl (phenol) sulfotransferase,thermolabile,monoamine neurotransmitters sulfating preferring,cytosolic

         Enzyme Numbers (IUBMB): EC 2.8.2.11 2 EC 2.8.22

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004062aryl sulfotransferase activity ----
    GO:0008146sulfotransferase activity ----
         
    SULT1A3 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SULT1A3 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Acetaminophen metabolism
    Acetaminophen Pathway, Pharmacokinetics0.43
    2-Naphthylamine and 2-Nitronaphtalene metabolism0.32
    2tryptophan utilization II
    tryptophan utilization II0.70
    serotonin degradation0.36
    tryptophan utilization I0.70
    3Drug metabolism - cytochrome P450
    Chemical carcinogenesis0.77
    4Cytosolic sulfonation of small molecules
    Sulfation Biotransformation Reaction0.52
    5Tamoxifen metabolism
    Estradiol metabolism0.52

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for SULT1A3
        Estradiol metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism


    2 GeneGo (Thomson Reuters) Pathways for SULT1A3
        Estradiol metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism

    5/6 BioSystems Pathways for SULT1A3 (see all 6)
        Sulfation Biotransformation Reaction
    dopamine degradation
    serotonin degradation
    metapathway biotransformation
    tryptophan utilization II


    5/8        Reactome Pathways for SULT1A3 (see all 8)
        Activation of Chaperone Genes by XBP1(S)
    Metabolism
    Biological oxidations
    Metabolism of proteins
    Activation of Chaperones by IRE1alpha

    1 PharmGKB Pathway for SULT1A3
        Acetaminophen Pathway, Pharmacokinetics

    1         Kegg Pathway  (Kegg details for SULT1A3):
        Chemical carcinogenesis


    SULT1A3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SULT1A3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/7 Interacting proteins for SULT1A3 (P502242, 3 ENSP000003436454) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271553 I2D: score=2 
    SMN2Q166372, 3MINT-8271553 I2D: score=2 
    TK1P041832, 3MINT-8274137 I2D: score=2 
    BPNT1ENSP000003188524STRING: ENSP00000318852
    PAPSS1ENSP000002651744STRING: ENSP00000265174
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006584catecholamine metabolic process ----
    GO:0006805xenobiotic metabolic process ----
    GO:0006987activation of signaling protein activity involved in unfolded protein response ----
    GO:0008202steroid metabolic process ----
    GO:0009812flavonoid metabolic process ----

    SULT1A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SULT1A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SULT1A3 (ST1A3)

    6 HMDB Compounds for SULT1A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Dopamine 3-O-sulfate4-(2-aminoethyl)-1,2-Benzenediol 2-(hydrogen sulfate) 51317-41-0--
    Dopamine 4-sulfate3-Hydroxytyramine-4-O-sulfate (see all 2)38339-02-5--
    Phenolacide carbolique (see all 51)108-95-2--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--
    Pyrocatechol1,2-Dihydroxybenzene (see all 20)120-80-9--

    10/52 Novoseek inferred chemical compound relationships for SULT1A3 gene (see all 52)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2,6-dichloro-4-nitrophenol 94 12 1687013 (2), 7859374 (1), 1355717 (1), 7755612 (1) (see all 7)
    3-phosphoadenosine 5'-phosphosulfate 88.8 6 10199779 (1), 12167648 (1), 15766710 (1), 15013851 (1)
    phenol 88.7 209 10638401 (6), 7755612 (6), 9321525 (4), 7667264 (4) (see all 99)
    p-nitrophenol 85.4 22 9882633 (3), 2390100 (2), 19646966 (2), 8093002 (2) (see all 14)
    3'-phosphoadenosine 5'-phosphate 84.7 4 16083857 (1), 10608851 (1), 15766710 (1)
    hydroxysteroid 80.5 6 8217878 (1), 9168894 (1), 9037254 (1), 7589232 (1) (see all 5)
    dhea 76 30 2390100 (2), 7859374 (2), 1355717 (2), 2327787 (1) (see all 16)
    3,3'-diiodothyronine 74.8 2 10199779 (1), 15531517 (1)
    minoxidil 73.4 19 7755612 (5), 2390100 (3), 8033267 (2), 7752059 (2) (see all 5)
    1-naphthol 72.6 1 9321525 (1)

    Search CenterWatch for drugs/clinical trials and news about SULT1A3 / ST1A3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SULT1A3 gene (3 alternative transcripts): 
    NM_177552.3  NM_001017387.1  NM_003166.3  

    Unigene Cluster for SULT1A3:

    Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
    Hs.460558  [show with all ESTs]
    Unigene Representative Sequence: NR_037608
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000567309 ENST00000338971 ENST00000395138(uc002dxk.3 uc010bzt.3)
    ENST00000569409 ENST00000563322 ENST00000569485 ENST00000562257 ENST00000563638
    ENST00000561549 ENST00000561533 ENST00000354723 ENST00000355544 ENST00000395137

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB111093.1 AB111094.1 AB111095.1 AB111096.1 AB111097.1 AB111098.1 AB111099.1 BC078144.1 
    BC132914.1 BC132920.1 BC144354.1 BC144355.1 BC171772.1 L25275.1 NR_037608.1 U08032.1 
    U34199.1 

    16 DOTS entries:

    DT.40105824  DT.101983748  DT.97862974  DT.92054627  DT.100671072  DT.100059108  DT.100671060  DT.417735 
    DT.87002066  DT.87016795  DT.91750591  DT.100059284  DT.120695783  DT.95099157  DT.91750585  DT.91750594 

    24/49 AceView cDNA sequences (see all 49):

    BX364127 BE206887 BX343076 BX358114 BX355834 BE047935 BX363887 AL523681 
    BU733432 BG683408 BF059587 AA814805 BX335419 AI962819 BM083418 AI271819 
    AI950219 AW235615 AA449716 BE281104 AI076858 AW205856 AW263633 AI188502 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SULT1A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCATTCACT
    SULT1A3 Expression
    About this image


    See SULT1A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SULT1A3

    SOURCE GeneReport for Unigene cluster: Hs.460558

    UniProtKB/Swiss-Prot: ST1A3_HUMAN, P50224
    Tissue specificity: Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SULT1A3 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SULT1E16
    Uncharacterized protein
    51(a)
    1 → many
    4(51214007-51215578)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    58(a)
    57(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343287.1(1045659-1052531)
    GL343287.1(1028874-1041016)
    zebrafish
    (Danio rerio)
    Actinopterygii sult1st66
    sult1st56
    sulfotransferase family 1, cytosolic sulfotransfer...
    sulfotransferase family 1, cytosolic sulfotransfer...
    46(a)
    44(a)
    possible ortholog
    possible ortholog
    12(16077368-16084598)
    23(24776416-24781150)
            Species with no ortholog for SULT1A3

    ENSEMBL Gene Tree for SULT1A3 (if available)
    TreeFam Gene Tree for SULT1A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SULT1A3 gene
    SULT1A41 2  SULT1C32  SULT4A12  SULT1B12  SULT1A22  SULT1C42  SULT1C22  SULT1E12  
    SULT2B12  SULT2A12  SULT6B12  SULT1A12  
    13 SIMAP similar genes for SULT1A3 using alignment to 3 protein entries:     ST1A3_HUMAN (see all proteins):
    SULT1A4    ST1A5    SULT1A1    SULT1A2    SULT1B1    SULT1E1
    SULT1C3    SULT1C4    SULT1C2    SULT2A1    SULT2B1    SULT4A1
    SULT6B1

    SULT1A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for SULT1A3 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2714183CNV Deletion23290073
    nsv821543CNV Duplication20802225
    nsv471389CNV Duplication19718026
    nsv820959CNV Duplication20802225
    nsv498862CNV Loss21111241
    nsv9426CNV Gain18304495
    esv29892CNV Gain19812545
    nsv905711CNV Gain21882294
    esv22245CNV Gain19812545
    nsv9431CNV Gain+Loss18304495


    Human Gene Mutation Database (HGMD): SULT1A3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SULT1A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SULT1A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600641    OMIM disorders: --

    20/52 diseases for SULT1A3 (see all 52):    About MalaCards
    rheumatoid arthritis, association with    cerebral infarction    dengue shock syndrome    severe acute respiratory syndrome
    gastroschisis    plasmodium falciparum malaria    acute pancreatitis    endometrial adenocarcinoma
    batten disease    essential thrombocythemia    churg-strauss syndrome    antiphospholipid syndrome
    thromboembolism    acute myocardial infarction    hemolytic-uremic syndrome    deep vein thrombosis
    venous thromboembolism    wegener's granulomatosis    coronary heart disease    nephritis


    SULT1A3 for disorders           About GeneDecksing

    10/40 Novoseek inferred disease relationships for SULT1A3 gene (see all 40)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cell damage 56.5 17 8873509 (2), 9506572 (2), 15142226 (1), 15650543 (1) (see all 11)
    lupus erythematosus systemic 47.3 5 19907914 (1), 8147936 (1), 19067109 (1), 15209962 (1) (see all 5)
    colon carcinoma 45.7 2 11558573 (1), 10864017 (1)
    batten disease 42.2 5 7668357 (3), 7695637 (1)
    cardiovascular diseases 40.8 1 11274275 (1)
    atherosclerosis 38.2 5 16202556 (2), 18342864 (1), 11472730 (1), 12668515 (1)
    cerebral infarction 33.6 2 15142226 (1)
    veno-occlusive disease 31.5 1 9540759 (1)
    thrombosis 29.5 13 11472438 (2), 12871544 (2), 12439142 (1), 9462541 (1) (see all 5)
    infarction lacunar 25.5 2 11882328 (1), 15142226 (1)

    Human Genome Epidemiology (HuGE) Navigator: SULT1A3 (1 document)

    Export disorders for SULT1A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SULT1A3 gene, integrated from 9 sources (see all 294):
    (articles sorted by number of sources associating them with SULT1A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Thermolabile phenol sulfotransferase gene (STM): localization to human chromosome 16p11.2. (PubMed id 7829089)1, 2, 3, 9 Aksoy I.A....Weinshilboum R.M. (1994)
    2. Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization. (PubMed id 8117269)1, 2, 3, 9 Wood T.C.... Weinshilboum R.M. (1994)
    3. Human thermolabile phenol sulfotransferase gene (STM): molecular cloning and structural characterization. (PubMed id 7695637)1, 2, 9 Aksoy I.A. and Weinshilboum R.M. (1995)
    4. Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies. (PubMed id 8093002)1, 2, 9 Veronese M.E.... McManus M.E. (1994)
    5. Genomic organization and DNA sequence of the human catecholamine- sulfating phenol sulfotransferase gene (STM). (PubMed id 7802665)1, 2, 9 Dooley T.P.... Doggett N.A. (1994)
    6. Cloning and expression of cDNA encoding human placental estrogen sulfotransferase. (PubMed id 8187949)1, 2, 9 Bernier F.... Luu-The V. (1994)
    7. Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. (PubMed id 16083857)1, 2, 9 Lu J.H....Chang W.R. (2005)
    8. Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene. (PubMed id 7961757)1, 2, 9 Bernier F.... Luu-The V. (1994)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6818 HGNC: 11455 AceView: SULT1A3.2 Ensembl:ENSG00000261052 euGenes: HUgn6818
    ECgene: SULT1A3 Kegg: 6818 H-InvDB: SULT1A3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SULT1A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SULT1A3 gene:
    Search GeneIP for patents involving SULT1A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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