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Aliases for SULT1A3 Gene

Aliases for SULT1A3 Gene

  • Sulfotransferase Family 1A Member 3 2 3 5
  • Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 3 2 3
  • Catecholamine-Sulfating Phenol Sulfotransferase 3 4
  • Placental Estrogen Sulfotransferase 3 4
  • Aryl Sulfotransferase 1A3/1A4 3 4
  • TL-PST 3 4
  • ST1A3 3 4
  • HAST3 3 4
  • M-PST 3 4
  • STM 3 4
  • Thermolabile (Monoamine, M Form) Phenol Sulfotransferase 3
  • Monoamine-Sulfating Phenol Sulfotransferase 4
  • Monoamine-Sulfating Phenosulfotransferase 3
  • Sulfotransferase, Monoamine-Preferring 4
  • Thermolabile Phenol Sulfotransferase 4
  • Dopamine-Specific Sulfotransferase 3
  • Phenol Sulfotransferase 1A5 3
  • Sulfotransferase 1A3/1A4 4
  • Sulfotransferase 1A3 3
  • ST1A3/ST1A4 3
  • Sulfokinase 3
  • EC 4
  • ST1A5 3
  • HAST 3

External Ids for SULT1A3 Gene

Previous HGNC Symbols for SULT1A3 Gene

  • STM

Previous GeneCards Identifiers for SULT1A3 Gene

  • GC16M029624
  • GC16P030599
  • GC16P030203
  • GC16P030241
  • GC16P030112
  • GC16P030206
  • GC16P027869
  • GC16P030209
  • GC16P030213
  • GC16P030217

Summaries for SULT1A3 Gene

Entrez Gene Summary for SULT1A3 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]

GeneCards Summary for SULT1A3 Gene

SULT1A3 (Sulfotransferase Family 1A Member 3) is a Protein Coding gene. Diseases associated with SULT1A3 include Dengue Shock Syndrome and Ceroid Lipofuscinosis, Neuronal, 3. Among its related pathways are Drug metabolism - cytochrome P450 and Metabolism. GO annotations related to this gene include sulfotransferase activity and aryl sulfotransferase activity. An important paralog of this gene is SULT1A4.

UniProtKB/Swiss-Prot for SULT1A3 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

Gene Wiki entry for SULT1A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1A3 Gene

Genomics for SULT1A3 Gene

Regulatory Elements for SULT1A3 Gene

Enhancers for SULT1A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F030196 0.2 Ensembl 0.8 -2.3 -2328 1.0 GC16P030195 SULT1A3
GH16F030198 0.2 Ensembl 0.8 +0.2 228 2.1 SULT1A3 PIR44576
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SULT1A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SULT1A3 Gene

30,199,228 bp from pter
30,204,329 bp from pter
5,102 bases
Plus strand

Genomic View for SULT1A3 Gene

Genes around SULT1A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1A3 Gene

Proteins for SULT1A3 Gene

  • Protein details for SULT1A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sulfotransferase 1A3
    Protein Accession:
    Secondary Accessions:
    • B4DNV0
    • O95603
    • P50224
    • Q1ET66
    • Q6ZWJ5

    Protein attributes for SULT1A3 Gene

    295 amino acids
    Molecular mass:
    34196 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SULT1A3 Gene

    Alternative splice isoforms for SULT1A3 Gene


neXtProt entry for SULT1A3 Gene

Post-translational modifications for SULT1A3 Gene

Other Protein References for SULT1A3 Gene

No data available for DME Specific Peptides for SULT1A3 Gene

Domains & Families for SULT1A3 Gene

Gene Families for SULT1A3 Gene

Protein Domains for SULT1A3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfotransferase 1 family.
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1A3: view

Function for SULT1A3 Gene

Molecular function for SULT1A3 Gene

GENATLAS Biochemistry:
aryl (phenol) sulfotransferase,thermolabile,monoamine neurotransmitters sulfating preferring,cytosolic
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + a phenol = adenosine 3,5-bisphosphate + an aryl sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

Enzyme Numbers (IUBMB) for SULT1A3 Gene

Gene Ontology (GO) - Molecular Function for SULT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0008146 sulfotransferase activity IEA,IDA 20056724
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SULT1A3: view
genes like me logo Genes that share phenotypes with SULT1A3: view

Animal Model Products

miRNA for SULT1A3 Gene

miRTarBase miRNAs that target SULT1A3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SULT1A3 Gene

Localization for SULT1A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1A3 Gene


Subcellular locations from

Jensen Localization Image for SULT1A3 Gene COMPARTMENTS Subcellular localization image for SULT1A3 gene
Compartment Confidence
cytosol 5
extracellular 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SULT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT1A3: view

Pathways & Interactions for SULT1A3 Gene

genes like me logo Genes that share pathways with SULT1A3: view

Gene Ontology (GO) - Biological Process for SULT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006584 catecholamine metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006805 xenobiotic metabolic process IDA 20056724
GO:0008202 steroid metabolic process IEA --
GO:0009812 flavonoid metabolic process IDA 20056724
genes like me logo Genes that share ontologies with SULT1A3: view

No data available for SIGNOR curated interactions for SULT1A3 Gene

Drugs & Compounds for SULT1A3 Gene

(28) Drugs for SULT1A3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenol Approved, Experimental Pharma 45
Acetaminophen Approved Pharma Enzyme, substrate Cyclooxygenase inhibitor; may be selective for COX-3 978
Pyrocatechol Experimental Pharma 0

(31) Additional Compounds for SULT1A3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
Dopamine 3-O-sulfate
  • 4-(2-Aminoethyl)-1,2-Benzenediol 2-(hydrogen sulfate)
  • 4-(2-Aminoethyl)-1,2-Benzenediol 2-(hydrogen sulphate)
Dopamine 4-sulfate
  • 3-Hydroxytyramine-4-O-sulfate
  • 3-Hydroxytyramine-4-O-sulphate
  • Dopamine 4-O-sulfate
  • Dopamine 4-O-sulphate
Phenol sulphate
  • Aryl sulfate
  • Aryl sulphate
  • phenyl hydrogen sulfate
  • phenyl hydrogen sulphate
  • phenylsulfate
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
genes like me logo Genes that share compounds with SULT1A3: view

Transcripts for SULT1A3 Gene

Unigene Clusters for SULT1A3 Gene

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1A3 Gene

No ASD Table

Relevant External Links for SULT1A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SULT1A3 Gene

mRNA expression in normal human tissues for SULT1A3 Gene

Protein differential expression in normal tissues from HIPED for SULT1A3 Gene

This gene is overexpressed in Platelet (8.4), Lymph node (7.6), and Fetal gut (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SULT1A3 Gene

Protein tissue co-expression partners for SULT1A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SULT1A3 Gene:


SOURCE GeneReport for Unigene cluster for SULT1A3 Gene:


mRNA Expression by UniProt/SwissProt for SULT1A3 Gene:

Tissue specificity: Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte.
genes like me logo Genes that share expression patterns with SULT1A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SULT1A3 Gene

Orthologs for SULT1A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC454364 34
  • 99.32 (n)
-- 35
  • 99 (a)
(Canis familiaris)
Mammalia SULT1A1 35
  • 83 (a)
(Bos Taurus)
Mammalia SULT1A1 35
  • 81 (a)
(Mus musculus)
Mammalia Sult1a1 35
  • 73 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
-- 35
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5428 36
  • 34 (a)
CG5431 36
  • 31 (a)
CG16733 36
  • 28 (a)
Species where no ortholog for SULT1A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SULT1A3 Gene

Gene Tree for SULT1A3 (if available)
Gene Tree for SULT1A3 (if available)

Paralogs for SULT1A3 Gene

(13) SIMAP similar genes for SULT1A3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SULT1A3: view

Variants for SULT1A3 Gene

Sequence variations from dbSNP and Humsavar for SULT1A3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1059667 -- 30,204,300(+) CTCAA(A/T)TAAAA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs112327790 -- 30,201,854(+) ACACC(C/T)GGCTA intron-variant
rs140113532 -- 30,201,711(+) TTTTT(-/T)GAGAC intron-variant
rs142024916 -- 30,197,316(+) GCCAG(A/G)TGGAC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs151163643 -- 30,200,654(+) AAAAA(-/A)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULT1A3 Gene

Variant ID Type Subtype PubMed ID
esv22245 CNV gain 19812545
esv2714183 CNV deletion 23290073
esv2758641 CNV gain 17122850
esv2758642 CNV gain 17122850
esv29892 CNV gain 19812545
esv3388213 CNV duplication 20981092
esv3392583 CNV duplication 20981092
esv3406739 CNV duplication 20981092
esv3444439 CNV duplication 20981092
esv3451126 CNV duplication 20981092
nsv1056249 CNV gain 25217958
nsv1078392 CNV duplication 25765185
nsv1078393 CNV duplication 25765185
nsv1139652 CNV duplication 24896259
nsv1141284 CNV duplication 24896259
nsv1146152 CNV duplication 26484159
nsv1148121 CNV duplication 26484159
nsv471389 CNV gain 19718026
nsv498862 CNV loss 21111241
nsv571809 CNV loss 21841781
nsv571810 CNV loss 21841781
nsv571811 CNV loss 21841781
nsv571819 CNV gain 21841781
nsv820959 CNV duplication 20802225
nsv821543 CNV duplication 20802225
nsv9426 CNV gain 18304495
nsv9431 CNV gain+loss 18304495
nsv953799 CNV deletion 24416366
nsv960011 CNV duplication 23825009
nsv977952 CNV duplication 23825009
nsv977954 CNV duplication 23825009

Variation tolerance for SULT1A3 Gene

Gene Damage Index Score: 0.01; 0.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULT1A3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1A3 Gene

Disorders for SULT1A3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SULT1A3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dengue shock syndrome
  • dss
ceroid lipofuscinosis, neuronal, 3
  • batten disease
inhalation anthrax
  • pulmonary anthrax
dengue disease
  • breakbone fever
stroke, ischemic
  • ischemic stroke
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SULT1A3

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SULT1A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT1A3 Gene

Publications for SULT1A3 Gene

  1. Thermolabile phenol sulfotransferase gene (STM): localization to human chromosome 16p11.2. (PMID: 7829089) Aksoy I.A. … Weinshilboum R.M. (Genomics 1994) 2 3 4 22 64
  2. Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization. (PMID: 8117269) Wood T.C. … Weinshilboum R.M. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 22 64
  3. Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. (PMID: 16083857) Lu J.H. … Chang W.R. (Biochem. Biophys. Res. Commun. 2005) 3 4 22 64
  4. Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism. (PMID: 14622112) Thomae B.A. … Weinshilboum R.M. (J. Neurochem. 2003) 3 4 22 64
  5. Human thermolabile phenol sulfotransferase gene (STM): molecular cloning and structural characterization. (PMID: 7695637) Aksoy I.A. … Weinshilboum R.M. (Biochem. Biophys. Res. Commun. 1995) 3 4 22 64

Products for SULT1A3 Gene

Sources for SULT1A3 Gene

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