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Aliases for SULT1A3 Gene

Aliases for SULT1A3 Gene

  • Sulfotransferase Family 1A Member 3 2 3 5
  • Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 3 2 3
  • Catecholamine-Sulfating Phenol Sulfotransferase 3 4
  • Placental Estrogen Sulfotransferase 3 4
  • Aryl Sulfotransferase 1A3/1A4 3 4
  • TL-PST 3 4
  • ST1A3 3 4
  • HAST3 3 4
  • M-PST 3 4
  • STM 3 4
  • Thermolabile (Monoamine, M Form) Phenol Sulfotransferase 3
  • Monoamine-Sulfating Phenol Sulfotransferase 4
  • Monoamine-Sulfating Phenosulfotransferase 3
  • Sulfotransferase, Monoamine-Preferring 4
  • Thermolabile Phenol Sulfotransferase 4
  • Dopamine-Specific Sulfotransferase 3
  • Phenol Sulfotransferase 1A5 3
  • Sulfotransferase 1A3/1A4 4
  • Sulfotransferase 1A3 3
  • ST1A3/ST1A4 3
  • Sulfokinase 3
  • EC 2.8.2.1 4
  • ST1A5 3
  • HAST 3

External Ids for SULT1A3 Gene

Previous HGNC Symbols for SULT1A3 Gene

  • STM

Previous GeneCards Identifiers for SULT1A3 Gene

  • GC16M029624
  • GC16P030599
  • GC16P030203
  • GC16P030241
  • GC16P030112
  • GC16P030206
  • GC16P027869
  • GC16P030209
  • GC16P030213
  • GC16P030217

Summaries for SULT1A3 Gene

Entrez Gene Summary for SULT1A3 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]

GeneCards Summary for SULT1A3 Gene

SULT1A3 (Sulfotransferase Family 1A Member 3) is a Protein Coding gene. Diseases associated with SULT1A3 include Dengue Shock Syndrome and Ceroid Lipofuscinosis, Neuronal, 3. Among its related pathways are Acetaminophen Pathway (therapeutic doses), Pharmacokinetics and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include sulfotransferase activity and aryl sulfotransferase activity. An important paralog of this gene is SULT1A4.

UniProtKB/Swiss-Prot for SULT1A3 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

Gene Wiki entry for SULT1A3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1A3 Gene

Genomics for SULT1A3 Gene

Regulatory Elements for SULT1A3 Gene

Enhancers for SULT1A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G030196 0.5 Ensembl dbSUPER 0.7 -2.4 -2355 0.7 GC16P030195 SULT1A3
GH16G030199 0.5 Ensembl dbSUPER 0.7 +0.4 408 1.7 SULT1A3 PIR44576
GH16G030198 0.2 dbSUPER 0.7 -0.7 -743 0.6 SULT1A3 GC16P030195
GH16G030202 0.2 dbSUPER 0.7 +3.6 3576 1.6 PIR44576 SULT1A3
GH16G030197 0.2 dbSUPER 0.7 -1.7 -1748 0.2 SULT1A3 GC16P030195
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SULT1A3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SULT1A3 gene promoter:

Genomic Location for SULT1A3 Gene

Chromosome:
16
Start:
30,199,228 bp from pter
End:
30,204,329 bp from pter
Size:
5,102 bases
Orientation:
Plus strand

Genomic View for SULT1A3 Gene

Genes around SULT1A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1A3 Gene

Proteins for SULT1A3 Gene

  • Protein details for SULT1A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMM9-ST1A3_HUMAN
    Recommended name:
    Sulfotransferase 1A3
    Protein Accession:
    P0DMM9
    Secondary Accessions:
    • B4DNV0
    • O95603
    • P50224
    • Q1ET66
    • Q6ZWJ5

    Protein attributes for SULT1A3 Gene

    Size:
    295 amino acids
    Molecular mass:
    34196 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SULT1A3 Gene

    Alternative splice isoforms for SULT1A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT1A3 Gene

Post-translational modifications for SULT1A3 Gene

Other Protein References for SULT1A3 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SULT1A3

No data available for DME Specific Peptides for SULT1A3 Gene

Domains & Families for SULT1A3 Gene

Gene Families for SULT1A3 Gene

Protein Domains for SULT1A3 Gene

Graphical View of Domain Structure for InterPro Entry

P0DMM9

UniProtKB/Swiss-Prot:

ST1A3_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1A3: view

Function for SULT1A3 Gene

Molecular function for SULT1A3 Gene

GENATLAS Biochemistry:
aryl (phenol) sulfotransferase,thermolabile,monoamine neurotransmitters sulfating preferring,cytosolic
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + a phenol = adenosine 3,5-bisphosphate + an aryl sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

Enzyme Numbers (IUBMB) for SULT1A3 Gene

Gene Ontology (GO) - Molecular Function for SULT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0008146 sulfotransferase activity IDA,IEA 20056724
GO:0016740 transferase activity IEA --
GO:0043199 sulfate binding IDA 10543947
genes like me logo Genes that share ontologies with SULT1A3: view
genes like me logo Genes that share phenotypes with SULT1A3: view

Animal Model Products

CRISPR Products

miRNA for SULT1A3 Gene

miRTarBase miRNAs that target SULT1A3

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SULT1A3 Gene

Localization for SULT1A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1A3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT1A3 gene
Compartment Confidence
cytosol 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SULT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT1A3: view

Pathways & Interactions for SULT1A3 Gene

genes like me logo Genes that share pathways with SULT1A3: view

Gene Ontology (GO) - Biological Process for SULT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006068 ethanol catabolic process IDA 23207770
GO:0006584 catecholamine metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006805 xenobiotic metabolic process IDA 20056724
GO:0007212 dopamine receptor signaling pathway IDA 24136195
genes like me logo Genes that share ontologies with SULT1A3: view

No data available for SIGNOR curated interactions for SULT1A3 Gene

Drugs & Compounds for SULT1A3 Gene

(29) Drugs for SULT1A3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenol Approved, Experimental Pharma 49
Acetaminophen Approved Pharma Enzyme, substrate Cyclooxygenase inhibitor; may be selective for COX-3 1026
Pyrocatechol Experimental Pharma 0

(30) Additional Compounds for SULT1A3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Dopamine 3-O-sulfate
  • 4-(2-Aminoethyl)-1,2-Benzenediol 2-(hydrogen sulfate)
  • 4-(2-Aminoethyl)-1,2-Benzenediol 2-(hydrogen sulphate)
51317-41-0
Dopamine 4-sulfate
  • 3-Hydroxytyramine-4-O-sulfate
  • 3-Hydroxytyramine-4-O-sulphate
  • Dopamine 4-O-sulfate
  • Dopamine 4-O-sulphate
38339-02-5
Phenol sulphate
  • Aryl sulfate
  • Aryl sulphate
  • phenyl hydrogen sulfate
  • phenyl hydrogen sulphate
  • phenylsulfate
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with SULT1A3: view

Transcripts for SULT1A3 Gene

Unigene Clusters for SULT1A3 Gene

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1A3 Gene

No ASD Table

Relevant External Links for SULT1A3 Gene

GeneLoc Exon Structure for
SULT1A3
ECgene alternative splicing isoforms for
SULT1A3

Expression for SULT1A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SULT1A3 Gene

Protein differential expression in normal tissues from HIPED for SULT1A3 Gene

This gene is overexpressed in Platelet (8.4), Lymph node (7.6), and Fetal gut (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SULT1A3 Gene



Protein tissue co-expression partners for SULT1A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SULT1A3 Gene:

SULT1A3

SOURCE GeneReport for Unigene cluster for SULT1A3 Gene:

Hs.460558

mRNA Expression by UniProt/SwissProt for SULT1A3 Gene:

P0DMM9-ST1A3_HUMAN
Tissue specificity: Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte.

Evidence on tissue expression from TISSUES for SULT1A3 Gene

  • Liver(4.6)
  • Kidney(4.5)
  • Blood(4.4)
  • Nervous system(4.4)
  • Lung(4.2)
  • Pancreas(4)
  • Intestine(2.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with SULT1A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT1A3 Gene

Orthologs for SULT1A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC454364 34
  • 99.32 (n)
-- 35
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SULT1A1 35
  • 83 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SULT1A1 35
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sult1a1 35
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5428 36
  • 34 (a)
CG5431 36
  • 31 (a)
CG16733 36
  • 28 (a)
Species where no ortholog for SULT1A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SULT1A3 Gene

ENSEMBL:
Gene Tree for SULT1A3 (if available)
TreeFam:
Gene Tree for SULT1A3 (if available)

Paralogs for SULT1A3 Gene

(13) SIMAP similar genes for SULT1A3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SULT1A3: view

Variants for SULT1A3 Gene

Sequence variations from dbSNP and Humsavar for SULT1A3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1005284345 -- 30,197,850(+) GCTTC(C/G)AAGTC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1012475256 -- 30,197,522(+) GGTCC(A/G)GCAGG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1014971225 -- 30,197,882(+) TCTAC(A/G)GAGCC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1029479460 -- 30,201,046(+) GTAAC(C/T)GGGCT nc-transcript-variant, reference, missense
rs1049757961 -- 30,197,657(+) GCAGG(A/C)GGGGC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SULT1A3 Gene

Variant ID Type Subtype PubMed ID
esv22245 CNV gain 19812545
esv2714183 CNV deletion 23290073
esv2758641 CNV gain 17122850
esv2758642 CNV gain 17122850
esv29892 CNV gain 19812545
esv3388213 CNV duplication 20981092
esv3392583 CNV duplication 20981092
esv3406739 CNV duplication 20981092
esv3444439 CNV duplication 20981092
esv3451126 CNV duplication 20981092
nsv1056249 CNV gain 25217958
nsv1078392 CNV duplication 25765185
nsv1078393 CNV duplication 25765185
nsv1139652 CNV duplication 24896259
nsv1141284 CNV duplication 24896259
nsv1146152 CNV duplication 26484159
nsv1148121 CNV duplication 26484159
nsv471389 CNV gain 19718026
nsv498862 CNV loss 21111241
nsv571809 CNV loss 21841781
nsv571810 CNV loss 21841781
nsv571811 CNV loss 21841781
nsv571819 CNV gain 21841781
nsv820959 CNV duplication 20802225
nsv821543 CNV duplication 20802225
nsv9426 CNV gain 18304495
nsv9431 CNV gain+loss 18304495
nsv953799 CNV deletion 24416366
nsv960011 CNV duplication 23825009
nsv977952 CNV duplication 23825009
nsv977954 CNV duplication 23825009

Variation tolerance for SULT1A3 Gene

Gene Damage Index Score: 0.01; 0.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULT1A3 Gene

Human Gene Mutation Database (HGMD)
SULT1A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT1A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1A3 Gene

Disorders for SULT1A3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SULT1A3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dengue shock syndrome
  • dss
ceroid lipofuscinosis, neuronal, 3
  • batten disease
inhalation anthrax
  • pulmonary anthrax
dengue disease
  • dengue hemorrhagic fever
stroke, ischemic
  • ischemic stroke
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SULT1A3

Human Genome Epidemiology (HuGE) Navigator
SULT1A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SULT1A3
genes like me logo Genes that share disorders with SULT1A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT1A3 Gene

Publications for SULT1A3 Gene

  1. Thermolabile phenol sulfotransferase gene (STM): localization to human chromosome 16p11.2. (PMID: 7829089) Aksoy I.A. … Weinshilboum R.M. (Genomics 1994) 2 3 4 22 64
  2. Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization. (PMID: 8117269) Wood T.C. … Weinshilboum R.M. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 22 64
  3. Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. (PMID: 16083857) Lu J.H. … Chang W.R. (Biochem. Biophys. Res. Commun. 2005) 3 4 22 64
  4. Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism. (PMID: 14622112) Thomae B.A. … Weinshilboum R.M. (J. Neurochem. 2003) 3 4 22 64
  5. Human thermolabile phenol sulfotransferase gene (STM): molecular cloning and structural characterization. (PMID: 7695637) Aksoy I.A. … Weinshilboum R.M. (Biochem. Biophys. Res. Commun. 1995) 3 4 22 64

Products for SULT1A3 Gene

Sources for SULT1A3 Gene

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