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Aliases for SULT1A3 Gene

Aliases for SULT1A3 Gene

  • Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 3 2 3
  • STM 3 4 6
  • Catecholamine-Sulfating Phenol Sulfotransferase 3 4
  • Placental Estrogen Sulfotransferase 3 4
  • Aryl Sulfotransferase 1A3/1A4 3 4
  • TL-PST 3 4
  • HAST3 3 4
  • M-PST 3 4
  • ST1A3 3 4
  • Thermolabile (Monoamine, M Form) Phenol Sulfotransferase 3
  • Monoamine-Sulfating Phenol Sulfotransferase 4
  • Monoamine-Sulfating Phenosulfotransferase 3
  • Sulfotransferase, Monoamine-Preferring 4
  • Thermolabile Phenol Sulfotransferase 4
  • Dopamine-Specific Sulfotransferase 3
  • Phenol Sulfotransferase 1A5 3
  • Sulfotransferase 1A3/1A4 4
  • Sulfotransferase 1A3 3
  • ST1A3/ST1A4 3
  • Sulfokinase 3
  • EC 2.8.2.1 4
  • ST1A5 3
  • HAST 3

External Ids for SULT1A3 Gene

Previous Symbols for SULT1A3 Gene

  • STM

Summaries for SULT1A3 Gene

Entrez Gene Summary for SULT1A3 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]

GeneCards Summary for SULT1A3 Gene

SULT1A3 (Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 3) is a Protein Coding gene. Diseases associated with SULT1A3 include peripheral artery disease and dengue shock syndrome. Among its related pathways are Metabolism and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot for SULT1A3 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs

Gene Wiki entry for SULT1A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1A3 Gene

Genomics for SULT1A3 Gene

Genomic Location for SULT1A3 Gene

Start:
30,199,228 bp from pter
End:
30,204,329 bp from pter
Size:
5,102 bases
Orientation:
Plus strand

Genomic View for SULT1A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SULT1A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1A3 Gene

Regulatory Elements for SULT1A3 Gene

Transcription factor binding sites by QIAGEN in the SULT1A3 gene promoter:

Proteins for SULT1A3 Gene

  • Protein details for SULT1A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMM9-ST1A3_HUMAN
    Recommended name:
    Sulfotransferase 1A3
    Protein Accession:
    P0DMM9
    Secondary Accessions:
    • B4DNV0
    • O95603
    • P50224
    • Q1ET66
    • Q6ZWJ5

    Protein attributes for SULT1A3 Gene

    Size:
    295 amino acids
    Molecular mass:
    34196 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SULT1A3 Gene

    Alternative splice isoforms for SULT1A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT1A3 Gene

Proteomics data for SULT1A3 Gene at MOPED

Post-translational modifications for SULT1A3 Gene

Other Protein References for SULT1A3 Gene

No data available for DME Specific Peptides for SULT1A3 Gene

Domains for SULT1A3 Gene

Gene Families for SULT1A3 Gene

HGNC:
  • SULT :Sulfotransferases, cytosolic

Protein Domains for SULT1A3 Gene

Graphical View of Domain Structure for InterPro Entry

P0DMM9

UniProtKB/Swiss-Prot:

ST1A3_HUMAN
Family:
  • Belongs to the sulfotransferase 1 family.:
    • P0DMM9
genes like me logo Genes that share domains with SULT1A3: view

No data available for Suggested Antigen Peptide Sequences for SULT1A3 Gene

Function for SULT1A3 Gene

Molecular function for SULT1A3 Gene

GENATLAS Biochemistry: aryl (phenol) sulfotransferase,thermolabile,monoamine neurotransmitters sulfating preferring,cytosolic
UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + a phenol = adenosine 3,5-bisphosphate + an aryl sulfate
UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs

Enzyme Numbers (IUBMB) for SULT1A3 Gene

Gene Ontology (GO) - Molecular Function for SULT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0008146 sulfotransferase activity IDA 20056724
genes like me logo Genes that share ontologies with SULT1A3: view

miRNA for SULT1A3 Gene

miRTarBase miRNAs that target SULT1A3

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SULT1A3 Gene

Localization for SULT1A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1A3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULT1A3 Gene COMPARTMENTS Subcellular localization image for SULT1A3 gene
Compartment Confidence
cytosol 4
nucleus 1

Gene Ontology (GO) - Cellular Components for SULT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT1A3: view

Pathways for SULT1A3 Gene

genes like me logo Genes that share pathways with SULT1A3: view

Gene Ontology (GO) - Biological Process for SULT1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006584 catecholamine metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IEA --
GO:0009812 flavonoid metabolic process IDA 20056724
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
genes like me logo Genes that share ontologies with SULT1A3: view

Compounds for SULT1A3 Gene

(6) HMDB Compounds for SULT1A3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Dopamine 3-O-sulfate
  • 4-(2-aminoethyl)-1,2-Benzenediol 2-(hydrogen sulfate)
51317-41-0
Dopamine 4-sulfate
  • 3-Hydroxytyramine-4-O-sulfate
38339-02-5
Phenol
  • acide carbolique
108-95-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
482-67-7

(52) Novoseek inferred chemical compound relationships for SULT1A3 Gene

Compound -log(P) Hits PubMed IDs
2,6-dichloro-4-nitrophenol 94 8
3-phosphoadenosine 5-phosphosulfate 88.8 4
phenol 88.7 155
p-nitrophenol 85.4 19
3-phosphoadenosine 5-phosphate 84.7 3
genes like me logo Genes that share compounds with SULT1A3: view

Transcripts for SULT1A3 Gene

Unigene Clusters for SULT1A3 Gene

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1A3 Gene

No ASD Table

Relevant External Links for SULT1A3 Gene

GeneLoc Exon Structure for
SULT1A3
ECgene alternative splicing isoforms for
SULT1A3

Expression for SULT1A3 Gene

mRNA expression in normal human tissues for SULT1A3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SULT1A3 Gene

SOURCE GeneReport for Unigene cluster for SULT1A3 Gene Hs.460558

mRNA Expression by UniProt/SwissProt for SULT1A3 Gene

P0DMM9-ST1A3_HUMAN
Tissue specificity: Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte
genes like me logo Genes that share expressions with SULT1A3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SULT1A3 Gene

Orthologs for SULT1A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
LOC454364 35
  • 99.32 (n)
  • 98.31 (a)
cow
(Bos Taurus)
Mammalia SULT1A1 36
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SULT1A1 36
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sult1a1 36
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5431 37
  • 31 (a)
CG5428 37
  • 34 (a)
CG16733 37
  • 28 (a)
Species with no ortholog for SULT1A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SULT1A3 Gene

ENSEMBL:
Gene Tree for SULT1A3 (if available)
TreeFam:
Gene Tree for SULT1A3 (if available)

Paralogs for SULT1A3 Gene

Selected SIMAP similar genes for SULT1A3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SULT1A3: view

Variants for SULT1A3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SULT1A3 Gene

Variant ID Type Subtype PubMed ID
dgv845e1 CNV Complex 17122850
nsv905711 CNV Gain 21882294
esv29892 CNV Gain 19812545
esv2714183 CNV Deletion 23290073
nsv498862 CNV Loss 21111241
nsv820959 CNV Duplication 20802225
nsv9426 CNV Gain 18304495
dgv846e1 CNV Complex 17122850
dgv847e1 CNV Complex 17122850
nsv9431 CNV Gain+Loss 18304495
esv22245 CNV Gain 19812545
nsv821543 CNV Duplication 20802225
nsv471389 CNV Duplication 19718026

Relevant External Links for SULT1A3 Gene

HapMap Linkage Disequilibrium report
SULT1A3
Human Gene Mutation Database (HGMD)
SULT1A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SULT1A3 Gene

Disorders for SULT1A3 Gene

(40) Novoseek inferred disease relationships for SULT1A3 Gene

Disease -log(P) Hits PubMed IDs
cell damage 56.5 13
lupus erythematosus systemic 47.3 5
colon carcinoma 45.7 2
batten disease 42.2 4
cardiovascular diseases 40.8 1

Relevant External Links for SULT1A3

Human Genome Epidemiology (HuGE) Navigator
SULT1A3
genes like me logo Genes that share disorders with SULT1A3: view

No data available for UniProtKB/Swiss-Prot for SULT1A3 Gene

Publications for SULT1A3 Gene

  1. Thermolabile phenol sulfotransferase gene (STM): localization to human chromosome 16p11.2. (PMID: 7829089) Aksoy I.A. … Weinshilboum R.M. (Genomics 1994) 2 3 4 23
  2. Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization. (PMID: 8117269) Wood T.C. … Weinshilboum R.M. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 23
  3. Genomic organization and DNA sequence of the human catecholamine- sulfating phenol sulfotransferase gene (STM). (PMID: 7802665) Dooley T.P. … Doggett N.A. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  4. Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene. (PMID: 7961757) Bernier F. … Luu-The V. (J. Biol. Chem. 1994) 3 4 23
  5. Human thermolabile phenol sulfotransferase gene (STM): molecular cloning and structural characterization. (PMID: 7695637) Aksoy I.A. … Weinshilboum R.M. (Biochem. Biophys. Res. Commun. 1995) 3 4 23

Products for SULT1A3 Gene

Sources for SULT1A3 Gene

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