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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SULT1A3 Gene

protein-coding GIFtS: 64
GCID: GC16P030209

sulfotransferase family, cytosolic, 1A, phenol-preferring,...

(Previous symbol: STM)

Explore 59 diseases affiliated with
SULT1A3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 3¹ ²		ST1A5²
STM¹ ² ³ ⁵		Dopamine-Specific Sulfotransferase²
TL-PST¹ ² ³		Monoamine-Sulfating Phenosulfotransferase²
Aryl Sulfotransferase 1A3/1A4² ³		Phenol Sulfotransferase 1A5²
Catecholamine-Sulfating Phenol Sulfotransferase² ³		Sulfokinase¹
Placental Estrogen Sulfotransferase² ³		Sulfotransferase 1A3/1A4²
HAST3² ³		Thermolabile (Monoamine, M Form) Phenol Sulfotransferase²
M-PST² ³		Monoamine-Sulfating Phenol Sulfotransferase³
ST1A3/ST1A4² ³		Sulfotransferase, Monoamine-Preferring³
EC 2.8.2.1³ ⁸		Thermolabile Phenol Sulfotransferase³
HAST²		EC 2.8.2⁸

External Ids:	HGNC: 11455¹	Entrez Gene: 6818²	Ensembl: ENSG00000261052⁷	OMIM: 600641⁵	UniProtKB: P50224³

Export aliases for SULT1A3 gene to outside databases

Previous GC identifers: GC16M029624 GC16P030599 GC16P030203 GC16P030241 GC16P030112 GC16P030206 GC16P027869

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SULT1A3:

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic

compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene

structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase

with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene

and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes.

Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease

subunit homolog A) gene that encodes a protein containing GIY-YIG domains. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: ST1A3_HUMAN, P50224

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the

sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and

phenolic and catechol drugs

Gene Wiki entry for SULT1A3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SULT1A3 gene promoter:
CREB deltaCREB p300
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): SULT1A3 promoter sequence

Search SABiosciences Chromatin IP Primers for SULT1A3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SULT1A3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2

SULT1A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SULT1A3 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P030209: view genomic region (about GC identifiers)

Start:	30,205,743 bp from pter	End:	30,215,650 bp from pter
Size:	9,908 bases	Orientation:	plus strand

1 alternative location:

Chr16+ 30,205,213-30,215,631

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ST1A3_HUMAN, P50224 (See protein sequence)

Recommended Name: Sulfotransferase 1A3/1A4

Size: 295 amino acids; 34196 Da

Subunit: Homodimer

Subcellular location: Cytoplasm

2 PDB 3D structures from and Proteopedia for SULT1A3:

1CJM (3D)

2A3R (3D)

Secondary accessions: B4DNV0 O95603 Q6ZWJ5

Alternative splicing: 2 isoforms: P50224-1 P50224-2 (No experimental confirmation available. Ref.9 (BAC85507) sequence differs from that shown due to a frameshift in position 101)

Explore the universe of human proteins at neXtProt for SULT1A3: NX_P50224

Post-translational modifications:

The N-terminus is blocked¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P50224

4/11 DME Specific Peptides for SULT1A3 (P50224) (see all 11)

LYLFYED

FTVAQNE

SPFMRKG

FQARPDD

SULT1A3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_808220.1

ENSEMBL proteins:

ENSP00000343645 ENSP00000378570 ENSP00000454518 ENSP00000455372 ENSP00000456391

ENSP00000346760 ENSP00000347739 ENSP00000378569

Reactome Protein details: P50224
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SULT1A3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	--	--

SULT1A3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SULT1A3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SULT1A3 for domains About GeneDecksing

1 InterPro domain/family:

IPR000863 Sulfotransferase_dom

Graphical View of Domain Structure for InterPro Entry P50224

ProtoNet protein and cluster: P50224

1 Blocks protein family: IPB000863 Sulfotransferase

UniProtKB/Swiss-Prot: ST1A3_HUMAN, P50224

Similarity: Belongs to the sulfotransferase 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ST1A3_HUMAN, P50224

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the

sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and

phenolic and catechol drugs

Catalytic activity: 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate

Genatlas biochemistry entry for SULT1A3:

aryl (phenol) sulfotransferase,thermolabile,monoamine neurotransmitters sulfating preferring,cytosolic

Enzyme Numbers (IUBMB): EC 2.8.2.1¹ ² EC 2.8.2²

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SULT1A3 Browse MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SULT1A3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004062	aryl sulfotransferase activity	--	--
GO:0008146	sulfotransferase activity	--	--

SULT1A3 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

2-Naphthylamine and 2-Nitronaphtalene metabolism

2-Naphthylamine and 2-Nitronaphtalene metabolism

1.00

2-Naphthylamine and 2-Nitronaphtalene metabolism

0.95

Acetaminophen Pathway, Pharmacokinetics

Pathway_PA165986194 -need delete

1.00

Acetaminophen Pathway, Pharmacokinetics

1.00

serotonin degradation

serotonin degradation

1.00

dopamine degradation

0.58

Tamoxifen metabolism

Estradiol metabolism

0.52

Estradiol metabolism

0.52

Cytosolic sulfonation of small molecules

Sulfation Biotransformation Reaction

0.67

Sulfur metabolism

0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for SULT1A3

	Estradiol metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism

2 GeneGo (Thomson Reuters) Pathways for SULT1A3

	Estradiol metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism

4 BioSystems Pathways for SULT1A3

	Sulfation Biotransformation Reaction
	serotonin degradation
	dopamine degradation
	metapathway biotransformation

5/9 Reactome Pathways for SULT1A3 (see all 9)

	Expression of SULT1A3
	Metabolism
	Cytosolic sulfonation of small molecules
	Activation of Chaperone Genes by XBP1(S)
	Biological oxidations

2 PharmGKB Pathways for SULT1A3

	Acetaminophen Pathway, Pharmacokinetics
	Pathway_PA165986194 -need delete

1 Kegg Pathway (Kegg details for SULT1A3):

Sulfur metabolism

SULT1A3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SULT1A3

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/7 Interacting proteins for SULT1A3 (P50224^{2, 3} ENSP00000343645⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMN1	Q16637²^,³	MINT-8271553 I2D: score=2
SMN2	Q16637²^,³	MINT-8271553 I2D: score=2
TK1	P04183²^,³	MINT-8274137 I2D: score=2
BPNT1	ENSP00000318852⁴	STRING: ENSP00000318852
PAPSS1	ENSP00000265174⁴	STRING: ENSP00000265174

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006584	catecholamine metabolic process	--	--
GO:0006805	xenobiotic metabolic process	--	--
GO:0006987	activation of signaling protein activity involved in unfolded protein response	--	--
GO:0008202	steroid metabolic process	--	--
GO:0009812	flavonoid metabolic process	--	--

SULT1A3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SULT1A3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SULT1A3

6 HMDB Compounds for SULT1A3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine 3',5'-diphosphate	3,5-Diphosphoadenosine (see all 10)	1053-73-2	--
Dopamine 3-O-sulfate	4-(2-aminoethyl)-1,2-Benzenediol 2-(hydrogen sulfate)	51317-41-0	--
Dopamine 4-sulfate	3-Hydroxytyramine-4-O-sulfate (see all 2)	38339-02-5	--
Phenol	acide carbolique (see all 51)	108-95-2	--
Phosphoadenosine phosphosulfate	3'-Phospho-5'-adenylyl sulfate (see all 9)	482-67-7	--
Pyrocatechol	1,2-Dihydroxybenzene (see all 20)	120-80-9	--

10/52 Novoseek chemical compound relationships for SULT1A3 gene (see all 52) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
2,6-dichloro-4-nitrophenol	94	12	1687013 (2), 7859374 (1), 1355717 (1), 7755612 (1) (see all 7)
3-phosphoadenosine 5'-phosphosulfate	88.8	6	10199779 (1), 12167648 (1), 15766710 (1), 15013851 (1)
phenol	88.7	209	10638401 (6), 7755612 (6), 9321525 (4), 7667264 (4) (see all 99)
p-nitrophenol	85.4	22	9882633 (3), 2390100 (2), 19646966 (2), 8093002 (2) (see all 14)
3'-phosphoadenosine 5'-phosphate	84.7	4	16083857 (1), 10608851 (1), 15766710 (1)
hydroxysteroid	80.5	6	8217878 (1), 9168894 (1), 9037254 (1), 7589232 (1) (see all 5)
dhea	76	30	2390100 (2), 7859374 (2), 1355717 (2), 2327787 (1) (see all 16)
3,3'-diiodothyronine	74.8	2	10199779 (1), 15531517 (1)
minoxidil	73.4	19	7755612 (5), 2390100 (3), 8033267 (2), 7752059 (2) (see all 5)
1-naphthol	72.6	1	9321525 (1)

Search CenterWatch for drugs/clinical trials and news about SULT1A3 / ST1A3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SULT1A3 gene (3 alternative transcripts):

NM_177552.3 NM_001017387.1 NM_003166.3

Unigene Cluster for SULT1A3:

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3

Hs.741198 [show with all ESTs]

Unigene Representative Sequence: NR_037608

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000567309 ENST00000338971 ENST00000395138(uc002dxk.3 uc010bzt.3)

ENST00000569409 ENST00000563322 ENST00000569485 ENST00000562257 ENST00000563638

ENST00000561549 ENST00000561533 ENST00000354723 ENST00000355544 ENST00000395137

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Additional cDNA sequence: NR_037608.1

11 DOTS entries:

DT.40105824 DT.101983748 DT.100671072 DT.100059108 DT.417735 DT.100059284 DT.120695783 DT.95099157

DT.91750585 DT.91750594 DT.97862974

24/49 AceView cDNA sequences (see all 49):

BE206887 BX364127 BU733432 BX358114 AL523681 BX363887 BX355834 BE047935

BX343076 BX335419 BG683408 BM083418 AI962819 AA814805 BF059587 AA449716

AI271819 AW235615 AI950219 AW263633 BE281104 AI188502 T60101 AW205856

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SULT1A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCATTCACT

About this image
See SULT1A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SULT1A3

SOURCE GeneReport for Unigene cluster: Hs.741198

UniProtKB/Swiss-Prot: ST1A3_HUMAN, P50224

Tissue specificity: Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte

SABiosciences Custom PCR Arrays for SULT1A3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SULT1A3 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- --	--	58(a) 56(a)	many ↔ many many ↔ many	GL343287.1(1045659-1052531) GL343287.1(1030047-1040195)
zebrafish (Danio rerio)	Actinopterygii	sult1st3⁶ sult1st2⁶ (see all 6)	sulfotransferase family 1, cytosolic sulfotransfer... sulfotransferase family 1, cytosolic sulfotransfer... (see all 6)	48(a) 48(a) (see all 6)	many ↔ many many ↔ many (see all 6)	8(48713195-48735311) 8(48667606-48678955)
fruit fly (Drosophila melanogaster)	Insecta	CG5428³	sulfotransferase	34(a) (best of 3)		59F6 --

ENSEMBL Gene Tree for SULT1A3 (if available)
TreeFam Gene Tree for SULT1A3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SULT1A3 gene

SULT1A4¹ ² SULT1C3² SULT4A1² SULT1B1² SULT1C4² SULT1A2² SULT1C2² SULT2B1²

SULT1E1² SULT2A1² SULT6B1² SULT1A1²

13 SIMAP similar genes for SULT1A3 using alignment to 3 protein entries: ST1A3_HUMAN (see all proteins):

SULT1A4 ST1A5 SULT1A1 SULT1A2 SULT1B1 SULT1E1

SULT1C3 SULT1C4 SULT1C2 SULT2A1 SULT2B1 SULT4A1

SULT6B1

SULT1A3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199857631^1,2	F	--	30208575(+)	`ACCTGC/ACCCTC`	4	--	int¹ us2k¹		1		EU	1139
rs76641670^1,2	C	--	30215621(-)	`TTTTAA/TTTGAG`	3	--	ds500¹ nc-transcript-variantut3¹		0	--	--	--	--
rs150025137^1,2	--	--	30209233(+)	`GAAAAG/TCACCT`	4	--	ds500¹ int¹ us2k¹		0	--	--	--	--
rs140113532^1,2	--	--	30213020(+)	`TTTTT-/TGAGAC`	2	--	int¹		0	--	--	--	--
rs151163643^1,2	--	--	30211958(+)	`AAAAA-/AGAGAG`	2	--	int¹		0	--	--	--	--
rs145339365^1,2	--	--	30209530(+)	`TACAGA/GTGCCC`	2	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SULT1A3 (30205743 - 30215650 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for SULT1A3
14 CNVs: 30778 72522 88064 35383 72525 4001 30775 72521 72526 35382 72527 72520 77275 4000
Human Gene Mutation Database (HGMD): SULT1A3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SULT1A3 for disorders           About GeneDecksing

OMIM gene information: 600641    OMIM disorders: --

20/59 diseases for SULT1A3 (see all 59):    About MalaCards

churg-strauss syndrome disseminated intravascular coagulation deep vein thrombosis hemolytic-uremic syndrome

plasmodium falciparum malaria myocardial infarction acute myocardial infarction severe acute respiratory syndrome

type 2 diabetes mellitus batten disease coronary heart disease wegener's granulomatosis

lupus erythematosus antiphospholipid syndrome essential thrombocythemia dengue shock syndrome

essential hypertension atrial fibrillation systemic lupus erythematosus cerebral infarction

10/40 Novoseek disease relationships for SULT1A3 gene (see all 40) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cell damage	56.5	17	8873509 (2), 9506572 (2), 15142226 (1), 15650543 (1) (see all 11)
lupus erythematosus systemic	47.3	5	19907914 (1), 8147936 (1), 19067109 (1), 15209962 (1) (see all 5)
colon carcinoma	45.7	2	11558573 (1), 10864017 (1)
batten disease	42.2	5	7668357 (3), 7695637 (1)
cardiovascular diseases	40.8	1	11274275 (1)
atherosclerosis	38.2	5	16202556 (2), 18342864 (1), 11472730 (1), 12668515 (1)
cerebral infarction	33.6	2	15142226 (1)
veno-occlusive disease	31.5	1	9540759 (1)
thrombosis	29.5	13	11472438 (2), 12871544 (2), 12439142 (1), 9462541 (1) (see all 5)
infarction lacunar	25.5	2	11882328 (1), 15142226 (1)

Human Genome Epidemiology (HuGE) Navigator: SULT1A3 (1 document)

Export disorders for SULT1A3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SULT1A3 gene, integrated from 9 sources (see all 293):
(articles sorted by number of sources associating them with SULT1A3)

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world of online information

Thermolabile phenol sulfotransferase gene (STM): localization to human chromosome 16p11.2. (PubMed id 7829089)^{1, 2, 3, 9} Aksoy I.A....Weinshilboum R.M. (1994)
Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization. (PubMed id 8117269)^{1, 2, 3, 9} Wood T.C.... Weinshilboum R.M. (1994)
Human thermolabile phenol sulfotransferase gene (STM): molecular cloning and structural characterization. (PubMed id 7695637)^{1, 2, 9} Aksoy I.A. and Weinshilboum R.M. (1995)
Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies. (PubMed id 8093002)^{1, 2, 9} Veronese M.E.... McManus M.E. (1994)
Genomic organization and DNA sequence of the human catecholamine- sulfating phenol sulfotransferase gene (STM). (PubMed id 7802665)^{1, 2, 9} Dooley T.P.... Doggett N.A. (1994)
Cloning and expression of cDNA encoding human placental estrogen sulfotransferase. (PubMed id 8187949)^{1, 2, 9} Bernier F.... Luu-The V. (1994)
Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. (PubMed id 16083857)^{1, 2, 9} Lu J.H....Chang W.R. (2005)
Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene. (PubMed id 7961757)^{1, 2, 9} Bernier F.... Luu-The V. (1994)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6818	HGNC: 11455	AceView: SULT1A3.2	Ensembl:ENSG00000261052	euGenes: HUgn6818
ECgene: SULT1A3	Kegg: 6818	H-InvDB: SULT1A3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SULT1A3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SULT1A3 gene
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Patent Information for SULT1A3 gene:
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SULT1A3 (Gene Symbol)
Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 3
STM
TL-PST
Aryl Sulfotransferase 1A3/1A4
Catecholamine-Sulfating Phenol Sulfotransferase
Placental Estrogen Sulfotransferase
HAST3
M-PST
ST1A3/ST1A4
EC 2.8.2.1
HAST
ST1A5
Dopamine-Specific Sulfotransferase
Monoamine-Sulfating Phenosulfotransferase
Phenol Sulfotransferase 1A5
Sulfokinase
Sulfotransferase 1A3/1A4
Thermolabile (Monoamine, M Form) Phenol Sulfotransferase
Monoamine-Sulfating Phenol Sulfotransferase
Sulfotransferase, Monoamine-Preferring
Thermolabile Phenol Sulfotransferase
EC 2.8.2

Nephritis
BREAST CARCINOMA
Autoimmune Diseases
HYPERTENSION ARTERIAL
Vasculitis
Hyperinsulinemia
veno-occlusive disease
essential hypertension
sepsis
Venous Thrombosis
Acute myocardial infarction
INFARCT
COLON CARCINOMA
Infarction Lacunar
Atherosclerosis
Breast Cancer
Antiphospholipid Syndrome
cell damage
Myocardial Infarction
RENAL DISEASE
Pancreatitis
Cerebral Infarction
acute pancreatitis
Inflammation
OBESITY
Dengue
Hepatitis B
STROKE
Batten Disease
Renal Failure
Vascular Diseases
Cardiovascular Diseases
Tumors
Thrombosis
Necrosis
virus infection
Coronary Heart Disease
Lupus Erythematosus Systemic
Thromboembolism
Arthritis

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SULT1A3 Gene

sulfotransferase family, cytosolic, 1A, phenol-preferring,...

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